showing 36 of ~574560 from 574555 documents
Antipoxvirus Activity Evaluation of Optimized Corroles Based on Development of Autofluorescent ANCHOR Myxoma Virus
2021
International audience; A series of 43 antiviral corrole-based molecules have been tested on myxoma virus (Lausanne-like T1MYXV strain). An autofluorescent MYXV, with an ANCHOR cassette, has been used for the studies. A(2)B-fluorocorroles display various toxicities, from 40 being very toxic (CC50 = 1.7 mu M) to nontoxic 38 (CC50 > 50 mu M), whereas A(3)-fluorocorroles, with one to three fluorine atoms, are not toxic (with the exception of corroles 9, 10, and 22). In vitro, these compounds show a good selectivity index when used alone. Corrole 35 seems to be the most promising compound, which displays a high selectivity index with the lowest IC50. Interestingly, this "Hit" corrole is easy to…
Predicting Pharmacokinetics of Multisource Acyclovir Oral Products Through Physiologically Based Biopharmaceutics Modeling.
2021
Abstract Highly variable disposition after oral ingestion of acyclovir has been reported, although little is known regarding the underlying mechanisms. Different studies using the same reference product (Zovirax ®) showed that Cmax and AUC were respectively 44 and 35% lower in Saudi Arabians than Europeans, consistent with higher frequencies of reduced-activity polymorphs of the organic cation transporter (OCT1) in Europeans. In this study, the contribution of physiology (i.e., OCT1 activity) to the oral disposition of acyclovir immediate release (IR) tablets was hypothesized to be greater than dissolution. The potential role of OCT1 was studied in a validated physiologically-based biopharm…
Machine Learning Identification of Pro-arrhythmic Structures in Cardiac Fibrosis
2021
Cardiac fibrosis and other scarring of the heart, arising from conditions ranging from myocardial infarction to ageing, promotes dangerous arrhythmias by blocking the healthy propagation of cardiac excitation. Owing to the complexity of the dynamics of electrical signalling in the heart, however, the connection between different arrangements of blockage and various arrhythmic consequences remains poorly understood. Where a mechanism defies traditional understanding, machine learning can be invaluable for enabling accurate prediction of quantities of interest (measures of arrhythmic risk) in terms of predictor variables (such as the arrangement or pattern of obstructive scarring). In this st…
Effect of Rivaroxaban and Aspirin in Patients With Peripheral Artery Disease Undergoing Surgical Revascularization: Insights From the VOYAGER PAD Tri…
2021
Background: Patients with peripheral artery disease requiring lower extremity revascularization (LER) are at high risk of adverse limb and cardiovascular events. The VOYAGER PAD trial (Vascular Outcomes Study of ASA [Acetylsalicylic Acid] Along With Rivaroxaban in Endovascular or Surgical Limb Revascularization for PAD) demonstrated that rivaroxaban significantly reduced this risk. The efficacy and safety of rivaroxaban has not been described in patients who underwent surgical LER. Methods: The VOYAGER PAD trial randomized patients with peripheral artery disease after surgical and endovascular LER to rivaroxaban 2.5 mg twice daily plus aspirin or matching placebo plus aspirin and followed …
Optically Enhanced Electric Field Sensing Using Nitrogen-Vacancy Ensembles
2021
Nitrogen-vacancy (NV) centers in diamond have shown promise as inherently localized electric-field sensors, capable of detecting individual charges with nanometer resolution. Working with NV ensembles, we demonstrate that a detailed understanding of the internal electric field environment enables enhanced sensitivity in the detection of external electric fields. We follow this logic along two complementary paths. First, using excitation tuned near the NV's zero-phonon line, we perform optically detected magnetic resonance (ODMR) spectroscopy at cryogenic temperatures in order to precisely measure the NV center's excited-state susceptibility to electric fields. In doing so, we demonstrate th…
Searching for a clinically validated definition of “asymptomatic” COVID‐19 infection
2021
Multitechnique diagnostic analysis and 3D surveying prior to the restoration of St. Michael defeating Evil painting by Mattia Preti
2021
In this study, a multimethodological analysis involving optical and physical/chemical diagnostic techniques and 3D photogrammetric survey was successfully applied, for the first time, on the large oil on canvas St. Michael defeating Evil painting by Mattia Preti, located inside the Church of the Immaculate Conception of Sarria (Floriana) in Malta. Pigmenting agents, binder media, and raw materials were first characterized, both at elemental and molecular scales, through X-ray fluorescence spectroscopy (XRF), optical stereo microscopy (SM), scanning electron microscopy coupled with energy dispersive X-ray spectroscopy (SEM-EDX), Fourier transform infrared spectroscopy (FT-IR), and gas chroma…
The Development of Teachers' and Their Students' Social and Emotional Learning During the “Learning to Be Project”-Training Course in Five European C…
2021
This study was funded by a project Learning to Be: Development of Practices and Methodologies for Assessing Social, Emotional and Health Skills within Education Systems (#4120034) in the framework of Erasmus+ KA3 program (582955-EPP-1-2016-2-LT-EPPKA3-PI-POLICY). We are also grateful for funding by the Academy of Finland (#308352) and Finnish Strategic Research Council (#327242).
Comparative analysis of the coordinated motion of Hsp70s from different organelles observed by single-molecule three-color FRET.
2021
Cellular function depends on the correct folding of proteins inside the cell. Heat-shock proteins 70 (Hsp70s), being among the first molecular chaperones binding to nascently translated proteins, aid in protein folding and transport. They undergo large, coordinated intra- and interdomain structural rearrangements mediated by allosteric interactions. Here, we applied a three-color single-molecule Forster resonance energy transfer (FRET) combined with three-color photon distribution analysis to compare the conformational cycle of the Hsp70 chaperones DnaK, Ssc1, and BiP. By capturing three distances simultaneously, we can identify coordinated structural changes during the functional cycle. Be…
COVID–19. Effect of Moral Messages to Persuade the Population to Stay at Home in Spain, Chile, and Colombia
2021
1.362 / 5.000 Resultados de traducción Analizar si el contenido de tres mensajes morales (deontológico, utilitarismo ético, virtud ética) y un mensaje de control afectan diferencialmente la probabilidad de realizar cuatro comportamientos: lavarse las manos, participar en reuniones públicas, quedarse en casa/evitar el contacto social y reenviar el mensaje para informar a más personas. En nuestro estudio, el emisor del mensaje es un profesor universitario. Estas variables se miden en términos de sus intenciones de comportamiento y las intenciones de comportamiento de los demás (creencias sobre el comportamiento de los demás). Ensayo controlado aleatorizado. Nuestro estudio incluye el análisis…
Electronic structure of Rf + ( Z = 104 ) from ab initio calculations
2021
We report calculation of the energy spectrum and the spectroscopic properties of the superheavy element ion: Rf+. We use the four-component relativistic Dirac-Coulomb Hamiltonian and the multireference configuration interaction model to tackle the complex electronic structure problem that combines strong relativistic effects and electron correlation. We determine the energies of the ground and the low-lying excited states of Rf+, which originate from the 7s26d1,7s16d2,7s27p1, and 7s16d17p1 configurations. The results are discussed vis-à-vis the lighter homolog Hf+ ion. We also assess the uncertainties of the predicted energy levels. The main purpose of the presented calculations is to provi…
Growth of central polynomials of algebras with involution
2021
Let A be an associative algebra with involution ∗ over a field of characteristic zero. A central ∗-polynomial of A is a polynomial in non- commutative variables that takes central values in A. Here we prove the existence of two limits called the central ∗-exponent and the proper central ∗-exponent that give a measure of the growth of the central ∗-polynomials and proper central ∗-polynomials, respectively. Moreover, we compare them with the PI-∗-exponent of the algebra.
Softness Kernel and Nonlinear Electronic Responses
2021
Liver Resection for Intrahepatic Cholangiocarcinoma—Single-Center Experience with 286 Patients Undergoing Surgical Exploration over a Thirteen Year P…
2021
Background: Intrahepatic cholangiocarcinoma (iCCA) accounts for about 10% of primary liver cancer. Surgery is the only potentially curative treatment. We report on our current series of 229 consecutive hepatic resections for iCCA, which is one of the largest Western single-center series published so far. Methods: Between January 2008 to December 2020, a total of 286 patients underwent 307 surgical explorations for intended liver resection of iCCA at our department. Data were analyzed with regard to (1) preoperative treatment of tumor, (2) operative details, (3) perioperative morbidity and mortality, (4) histopathology, (5) outcome measured by tumor recurrence, treatment of recurrence and su…
Culture and Politics of Laziness. From Fairy Tales to Oblomov and Bartleby
2021
La these de cet article est que la paresse n’est pas une propriete psychologique d’un sujet individuel mais un sentiment collectif : c’est une reaction, voire une rebellion, contre ceux qui nous enferment dans une culture qui voit l’activite comme une valeur supreme, souvent comme une fin en soi. La paresse est la reponse a ceux qui nous forcent a faire et a exagerer, a nous donner a nos occupations avec zele et constance, devouement total et perseverance aveugle. Donc, il n’est pas vrai qu’une personne paresseuse ne fait rien, ou plutot qu’elle fait tout ce qu’elle peut pour ne rien faire. Le paresseux travaille frenetiquement afin de creer les conditions parfaites qui lui permettent d’act…
EUGENICS BETWEEN SCIENCE AND POLITICS IN LATVIA DURING WORLD WAR II: THE INVESTIGATION FILE OF THE MINISTRY OF STATE SECURITY OF THE LATVIAN SSR IN T…
2021
This study, based on the materials of the 1948 investigation of the Ministry of State Security of the Latvian SSR, traces and analyzes the scientific and administrative activities of Theodor Upners (1898-1992) during the Nazi occupation regime in Latvia. From 1942 until the end of the occupation in 1944, Upners was formally the leading eugenics specialist in Latvia. During this time, in 1942 he visited Germany on a scientific trip, gave a course on eugenics at the University of Riga, and in 1943 published the book «The Role of Eugenics in the Life of the Nation and the State». In the 1948 investigation, he was accused of collaborating with the Nazi occupation authorities and glorifying Nazi…
LC‐Polymers and Smectic Phases with Special Substructures/Nanophase Segregation
2021
Suspected-screening assessment of the occurrence of organic compounds in sewage sludge
2021
The profiling of emerging organic pollutants present in sludge and generated during wastewater treatment is much more limited than in water. This is mainly due to the difficulty of sludge analysis because of its high content of organic matter and interfering compounds. In this study, a generic extraction method using a mixture of buffered water (pH 4.1) and solid phase extraction (SPE) clean-up was applied to samples of sludge obtained in different treatment plants. This extraction was followed by determination of the contaminants by ultra-high performance liquid chromatography coupled to high resolution mass spectrometry (UHPLC-HRMS), using suspected screening to detect the most relevant o…
Regulation of the HTRA2 Protease Activity by an Inhibitory Antibody-Derived Peptide Ligand and the Influence on HTRA2-Specific Protein Interaction Ne…
2021
The mitochondrial serine protease HTRA2 has many versatile biological functions ranging from being an important regulator of apoptosis to being an essential component for neuronal cell survival and mitochondrial homeostasis. Loss of HTRA2 protease function is known to cause neurodegeneration, whereas overactivation of its proteolytic function is associated with cell death and inflammation. In accordance with this, our group verified in a recent study that the synthetic peptide ASGYTFTNYGLSWVR, encoding the hypervariable sequence part of an antibody, showed a high affinity for the target protein HTRA2 and triggered neuroprotection in an in vitro organ culture model for glaucoma. To unravel t…
Nursing students’ professional identity development: An integrative review
2021
The aim of this integrative review was to identify and synthesize current evidence of factors that influence the professional identity development of nursing students in nursing educational programs. Cinahl (EBSCO), Medline, ERIC, Embase, and PsycINFO were searched. Three different appraisal tools and the PRISMA checklist were used. The data from both quantitative and qualitative studies (19 primary studies) were analyzed by applying qualitative content analysis. The analysis revealed two main themes: a caring practice–academic partnership and support in the learning environment. The following seven sub-categories were identified: clinical supervisors, ethical competence, preparation, self…
When virtual and real worlds coexist: Visualization and visual system affect spatial performance in augmented reality
2021
New visualization approaches are being actively developed aiming to mitigate the effect of vergence-accommodation conflict in stereoscopic augmented reality; however, high interindividual variability in spatial performance makes it difficult to predict user gain. To address this issue, we investigated the effects of consistent and inconsistent binocular and focus cues on perceptual matching in the stereoscopic environment of augmented reality using a head-mounted display that was driven in multifocal and single focal plane modes. Participants matched the distance of a real object with images projected at three viewing distances, concordant with the display focal planes when driven in the mu…
Changes in neural drive to calf muscles during steady submaximal contractions after repeated static stretches
2021
Key points: Repeated static-stretching interventions consistently increase the range of motion about a joint and decrease total joint stiffness, but findings on the changes in muscle and connective-tissue properties are mixed. The influence of these stretch-induced changes on muscle function at submaximal forces is unknown. To address this gap in knowledge, the changes in neural drive to the plantar flexor muscles after a static-stretch intervention were estimated. Neural drive to the plantar flexor muscles during a low-force contraction increased after repeated static stretches. These findings suggest that adjustments in motor unit activity are necessary at low forces to accommodate reduct…
Daily energy expenditure through the human life course
2021
Total daily energy expenditure (“total expenditure”, MJ/d) reflects daily energy needs and is a critical variable in human health and physiology, yet it is unclear how daily expenditure changes over the life course. Here, we analyze a large, globally diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 yr. We show that total expenditure is strongly related to fat free mass in a power-law manner and identify four distinct metabolic life stages. Fat free mass-adjusted daily expenditure accelerates rapidly in neonates (0-1yr) to ~46% above adult values at ~1 yr, declines slowly throughout childhood and adolescence (1-20 yr) t…
Electrochemical Treatment of Wastewater by ElectroFenton, Photo-ElectroFenton, Pressurized- ElectroFenton and Pressurized Photo ElectroFenton: A Firs…
2021
In the last few years increasing attention has been devoted to the utilization of electroFenton (EF) and EF based technologies for the treatment of wastewater polluted by recalcitrant organics. It has been shown that the performances of EF can be strongly improved using ultraviolet (UV) irradiation, e.g., by the photo-electroFenton (PEF) method, or pressurized air or oxygen, e.g., by the pressurized-electroFenton (PrEF) one. Although several studies were carried out on the degradation of many organic pollutants using EF, PEF or PrEF, a systematic comparison between PEF and PrEF was never reported as well as the possibility to couple the irradiation with pressurized air. In this study the pe…
Many More Consumers Not Always Induce Stronger Competition: Weaker Interspecific Competition Despite Higher Species Richness in Secondary Feeding Gui…
2021
The species functional structuration (specifically in terms of species richness and average intensity of interspecific competition) is widely varying among species communities and this point is now very well documented in literature. But, what about the species functional structuration within the different feeding guilds that coexist in a same local community – in particular the primary and the secondary feeding guilds? Are there significant differences – or not – between them in this respect? This rather fundamental issue does not seem having been addressed yet, at least using appropriate investigative tools. However, a series of recently published case studies, precisely implementing such…
Electronic structure of Rf+ (Z=104) from ab initio calculations
2021
We report calculation of the energy spectrum and the spectroscopic properties of the superheavy element ion: ${\mathrm{Rf}}^{+}$. We use the four-component relativistic Dirac-Coulomb Hamiltonian and the multireference configuration interaction model to tackle the complex electronic structure problem that combines strong relativistic effects and electron correlation. We determine the energies of the ground and the low-lying excited states of ${\mathrm{Rf}}^{+}$, which originate from the $7{s}^{2}6{d}^{1},\phantom{\rule{0.28em}{0ex}}7{s}^{1}6{d}^{2},\phantom{\rule{0.28em}{0ex}}7{s}^{2}7{p}^{1}$, and $7{s}^{1}6{d}^{1}7{p}^{1}$ configurations. The results are discussed vis-\`a-vis the lighter h…
Unveiling the Different Reactivity of Bent and Linear Three-Atom-Components Participating in [3 + 2] Cycloaddition Reactions
2021
The reactivity of a series of pairs of bent and linear three-atom-component (B-TACs and L-TACs) participating in [3 + 2] cycloaddition (32CA) reactions towards ethylene and electrophilic dicyanoethylene (DCE) have been studied within the Molecular Electron Density Theory. While the pseudodiradical structure of B-TACs changes to that of pseudoradical or carbenoid L-TACs upon dehydrogenation, zwitterionic B-TACs remain unchanged. Conceptual Density Functional Theory (CDFT) indices characterize five of the nine TACs as strong nucleophiles participating in polar reactions towards electrophilic ethylenes. The activation energies of the 32CA reactions with electrophilic DCE range from 0.5 to 22.0…
Experience in Spain with the first patients in home hemodialysis treated with low-flow dialysate monitors
2021
Resumen La hemodialisis domiciliaria (HDD) con monitores de bajo flujo de liquido de dialisis ha ganado popularidad en los ultimos anos gracias a su sencillez de diseno, portabilidad y capacidad de desplazamiento. No obstante, existen dudas respecto a la adecuacion que este tipo de tecnica ofrece, pues utiliza monitores con bano a flujos bajos y lactato. El objetivo de este estudio fue demostrar los beneficios clinicos de la HDD con el monitor NxStage System One® introducido recientemente en Espana. Presentamos los resultados de un estudio observacional, retrospectivo que incluyo de manera no seleccionada a los primeros pacientes con HDD corta mediante este monitor en 12 centros en Espana. …
The Inflammatory Feed-Forward Loop Triggered by the Complement Component C3 as a Potential Target in Endometriosis
2021
Copyright © 2021 Agostinis, Zorzet, Balduit, Zito, Mangogna, Macor, Romano, Toffoli, Belmonte, Morello, Martorana, Borelli, Ricci, Kishore and Bulla. The complement system is a major component of humoral innate immunity, acting as a first line of defense against microbes via opsonization and lysis of pathogens. However, novel roles of the complement system in inflammatory and immunological processes, including in cancer, are emerging. Endometriosis (EM), a benign disease characterized by ectopic endometrial implants, shows certain unique features of cancer, such as the capacity to invade surrounding tissues, and in severe cases, metastatic properties. A defective immune surveillance against…
Sepiolite-Hydrogels: Synthesis by Ultrasound Irradiation and Their Use for the Preparation of Functional Clay-Based Nanoarchitectured Materials.
2021
International audience; Sepiolite and palygorskite fibrous clay minerals are 1D silicates featuring unique textural and structural characteristics useful in diverse applications, and in particular as rheological additives. Here we report on the ability of grinded sepiolite to generate highly viscous and stable hydrogels by sonomechanical irradiation (ultrasounds). Adequate drying of such hydrogels leads to low-density xerogels that show extensive fiber disaggregation compared to the starting sepiolite-whose fibers are agglomerated as bundles. Upon re-dispersion in water under high-speed shear, these xerogels show comparable rheological properties to commercially available defibrillated sepi…
Predicting emotions in music using the onset curve
2021
The relationship between parameters extracted from the musical stimuli and emotional response has been traditionally approached using several physical measures extracted from time or frequency domains. From time-domain measures, the musical onset is defined as the moment in that any musical instrument or human voice issues a musical note. The onsets’ sequence in the performance of a specific musical score creates what is known as the onset curve (OC). The influence of the structure of OC on the emotional judgment of people is not known. To this end, we have applied principal component analysis on a complete set of variables extracted from the OC to capture their statistical structure. We h…
Analysis of serum and endometrial progesterone in determining endometrial receptivity.
2021
Abstract STUDY QUESTION Is there a relationship between serum and endometrial progesterone (P4) levels, including P4 and metabolites (oestrone, oestradiol and 17α-hydroxyprogesterone), and endometrial receptivity? SUMMARY ANSWER Serum P4 levels were not correlated with endometrial P4, nor associated with endometrial receptivity as determined by the ERA® test; however, endometrial P4 and 17α-hydroxyprogesterone levels were positively correlated and related to endometrial receptivity by ERA. WHAT IS KNOWN ALREADY Acquisition of endometrial receptivity is governed by P4, which induces secretory transformation. A close relationship between serum P4 and pregnancy outcome is reported for hormone …
Quantum technologies and the elephants
2021
Extraordinary progress in quantum sensors and technologies opens new avenues for exploring the Universe and testing the assumptions forming the basis of modern physics. This QST focus issue: focus on quantum sensors for new-physics discoveries is a next-decade roadmap on developing a wide range of quantum sensors and new technologies towards discoveries of new physics. It covers the next generation of various technologies, including atomic and nuclear clocks, atomic and diamond-based magnetometers, atom and laser interferometers, control of trapped atoms, ions, and molecules, optomechanical systems, and many others. In this editorial, we outline major problems of fundamental physics we aim …
Female gender and low physical activity are risk factors for academic stress in incoming nursing students.
2021
PURPOSE Nursing students suffer from stress more frequently than other students. The objective was to analyze the academic stressors that most affect new nursing students. DESIGN AND METHODS A cross-sectional study on new nursing students. FINDINGS Two hundred and eighty-two students, 78% women, mean age of 21.46 (6.1) years. Giving presentations in class and lack of time for homework are the items that cause the greatest academic stress. Women had higher levels of academic stress, and higher levels of physical activity are related to lower academic stress. PRACTICE IMPLICATIONS Women have a higher level of academic stress. Doing sport is a protective factor that diminishes academic stress …
The Colombian geochronological database (CGD)
2021
Geochronological databases are powerful tools for characterizing the crustal evolution and the age spectra of a region and allow comparison with other areas at a regional scale. In this contributio...
Discrimination of non-infectious SARS-CoV-2 particles from fomites by viability RT-qPCR.
2021
The ongoing coronavirus 2019 (COVID-19) pandemic constitutes a concerning global threat to public health and economy. In the midst of this pandemic scenario, the role of environment-to-human COVID-19 spread is still a matter of debate because mixed results have been reported concerning SARS-CoV-2 stability on high-touch surfaces in real-life scenarios. Up to now, no alternative and accessible procedures for cell culture have been applied to evaluate SARS-CoV-2 infectivity on fomites. Several strategies based on viral capsid integrity have latterly been developed using viability markers to selectively remove false-positive qPCR signals resulting from free nucleic acids and damaged viruses. T…