showing 36 of ~574560 from 574555 documents
Biopsychosocial framework – pain impacting life on multiple biopsychosocial domains
2021
The current main guidelines recommend management of musculoskeletal conditions within a biopsychosocial framework [1]. From time to time, a question arises whether this is too early as there is not...
Measurements of Born cross sections of e+e−→Ds*+DsJ−+c.c.
2021
The Born cross sections are measured for the first time for the processes $e^+e^-\to D_s^{*+}D_{s0}^*(2317)^- +c.c.$ and $e^+e^-\to D_s^{*+}D_{s1}(2460)^- +c.c.$ at the center-of-mass energy $\sqrt{s}=$ 4.600~GeV, 4.612~GeV, 4.626~GeV, 4.640~GeV, 4.660~GeV, 4.68~GeV, and 4.700~GeV, and for $e^+e^-\to D_s^{*+}D_{s1}(2536)^- +c.c.$ at $\sqrt{s}=$ 4.660~GeV, 4.680~GeV, and 4.700~GeV, using data samples collected with the BESIII detector at the BEPCII collider. No structures are observed in cross-section distributions for any of the processes.
Do local proxy advisors matter? – Evidence from Germany
2021
Prior research documents that the large US-based proxy advisors, Institutional Shareholder Services (ISS) and Glass Lewis (GL), play an important role as information intermediaries in corporate gov...
L'impact du contentieux indemnitaire DALO sur les politiques du logement : coup d'épée dans l'eau ou ultime sursaut en faveur de l'effectivité du dro…
2021
International audience
Load Monitoring Practice in Elite Women Association Football
2021
The description of current load monitoring practices may serve to highlight developmental needs for both the training ground, academia and related industries. While previous studies described these practices in elite men's football, no study has provided an overview of load monitoring practices in elite women's football. Given the clear organizational differences (i.e., professionalization and infrastructure) between men's and women's clubs, making inferences based on men's data is not appropriate. Therefore, this study aims to provide a first overview of the current load monitoring practices in elite women's football. Twenty-two elite European women's football clubs participated in a close…
Fulvestrant and trastuzumab in patients with luminal HER2-positive advanced breast cancer (ABC): an Italian real-world experience (HERMIONE 9)
2021
Purpose: The most appropriate therapy for HR + /HER2-positive (HER2 +) advanced breast cancer (ABC) is a matter of debate. Co-targeting of both receptors represents an attractive strategy to overcome the cross-talk between them. Methods: The HERMIONE 9 is an observational retrospective multicentric study which aimed to describe the clinical outcome of patients with HR + /HER2 + ABC who received the combination of Fulvestrant (F) and Trastuzumab (T) as part of their routine treatment at 10 Italian Institutions. Results: Eighty-seven patients were included. Median age was 63 (range, 35–87) years. The median number of previous treatments was 3 (range, 0–10) and F and T were administered as ≥ 3…
The whip and the Bible : punishment versus internalization
2021
First published online: 27 August 2021 A variety of experimental and empirical research indicate that prosocial behavior is important for economic success. There are two sources of prosocial behavior: incentives and preferences. The latter, the willingness of individuals to “do their bit” for the group, we refer to as internalization, because we view it as something that a group can influence by appropriate investment. This implies that there is a trade-off between using incentives and internalization to encourage prosocial behavior. By examining this trade-off we shed light on the connection between social norms observed inside the laboratory and those observed outside in the field. For ex…
Riemann theta functions, Fredholm and wronskian representations of the solutions to the KdV equation
2021
We degenerate the finite gap solutions of the KdV equation from the general formulation given in terms of abelian functions when the gaps tends to points, to get solutions to the KdV equation given in terms of Fredholm determinants and wronskians. For this we establish a link between Riemann theta functions, Fredholm determinants and wronskians. This gives the bridge between the algebro-geometric approach and the Darboux dressing method.
New diagnostic and imaging technologies in dermatology
2021
INTRODUCTION Diagnosis of dermatological disorders is primarily based on clinical examination in combination with histopathology. However, clinical findings alone may not be sufficient for accurate diagnosis and cutaneous biopsies are being associated with morbidity. OBJECTIVE The objective of this article is to review the newer technologies along with their applications, limitation and future prospectus. METHODOLOGY Comprehensive literature search was performed using electronic online databases "PubMed" and "Google Scholar". Articles published in English language were considered for the review. RESULTS In order to improve and/or widen the armamentarium in dermatologic disease diagnosis and…
Machine learning study of the molecular drivers of natural product prices
2021
The price of chemicals is a very complex variable. It can be impacted by production costs but also by market and managerial factors, which may have complex relationships with molecular characteristics and the state of technology and society. In this work, we explore the extent to which molecular characteristics can help explain natural product prices with the aid of machine learning tools. We interpret models trained on molecular descriptors and molecular fingerprints. These models can explain a notable proportion of the variation in prices, suggesting that production and separation costs are a major contributor to current natural product prices. Some molecular properties stand out as key p…
Multiharmonic Correlations of Different Flow Amplitudes in Pb-Pb Collisions at ...
2021
The event-by-event correlations between three flow amplitudes are measured for the first time in Pb-Pb collisions, using higher-order symmetric cumulants. We find that different three-harmonic correlations develop during the collective evolution of the medium when compared to correlations that exist in the initial state. These new results cannot be interpreted in terms of previous lower-order flow measurements since contributions from two-harmonic correlations are explicitly removed in the new observables. A comparison to Monte Carlo simulations provides new and independent constraints for the initial conditions and system properties of nuclear matter created in heavy-ion collisions. © 2021…
What, where, when and how : Finnish children’s perceptions of learning in preschool
2021
To be able to support young children in learning to learn—an ability that requires adapting often-unprecedented changes in society—teachers need to be aware of the ways in which children understand learning. In this qualitative study, 177 micro-interviews conducted with 41 Finnish children were analysed using an abductive method to understand their perceptions of learning in a preschool. Learning was perceived as learning to do or know things. Academic skills and contents, followed by motoric skills and sports, arts and crafts, socio-emotional skills and everyday skills, were mentioned as the learning contents. In addition, intentional teaching, teacher-initiated exercises, practising, cogn…
Multiharmonic Correlations of Different Flow Amplitudes in Pb-Pb Collisions at √sNN = 2.76 TeV
2021
The event-by-event correlations between three flow amplitudes are measured for the first time in Pb-Pb collisions, using higher-order symmetric cumulants. We find that different three-harmonic correlations develop during the collective evolution of the medium when compared to correlations that exist in the initial state. These new results cannot be interpreted in terms of previous lower-order flow measurements since contributions from two-harmonic correlations are explicitly removed in the new observables. A comparison to Monte Carlo simulations provides new and independent constraints for the initial conditions and system properties of nuclear matter created in heavy-ion collisions. peerRe…
The role of working memory on writing processes.
2021
Literature has extensively demonstrated the coordination role of working memory (WM) in complex tasks such as writing. However, previous studies mostly concentrated on the relation between passive WM (e.g., WM span) components and specific writing tasks (e.g., dictation). Here, we aimed to investigate the relationship between different writing skills and the performance on a WM updating task measuring the more active components of WM. From a pool of 160 Italian pupils (grades 3–5), we selected 46 children divided in two groups based on their WM updating performance. The first group consisted of 21 children with low WM updating performance (≤10th percentile), the second group consisted of 25…
Multicomponent Synthesis of Benzothiophen-2-acetic Esters by a Palladium Iodide Catalyzed S-cyclization – Alkoxycarbonylation Sequence
2021
A catalytic carbonylative approach to the multicomponent synthesis of benzothiophene derivatives from simple building blocks [1-(2-(methylthio)phenyl)prop-2-yn-1-ols, carbon monoxide, and an alcohol)] is presented. It is based on an S-cyclization-demethylation-alkoxycarbonylation-reduction sequence promoted by the PdI2/KI catalytic system, occurring under relatively mild conditions (40 atm, 80 °C, 15 h). Benzothiophene-2-acetic esters are obtained in moderate to good yields (35–70%) starting from variously substituted substrates in combination with different alcohols as external nucleophiles (17 examples). (Figure presented.).
Expression and subcellular localization of USH1C/harmonin in the human retina provide insights into pathomechanisms and therapy
2021
AbstractUsher syndrome (USH) is the most common form of hereditary deafness-blindness in humans. USH is a complex genetic disorder, assigned to three clinical subtypes differing in onset, course, and severity, with USH1 being the most severe. Rodent USH1 models do not reflect the ocular phenotype observed in human patients to date; hence, little is known about the pathophysiology of USH1 in the human eye. One of the USH1 genes, USH1C, exhibits extensive alternative splicing and encodes numerous harmonin protein isoforms that function as scaffolds for organizing the USH interactome. RNA-seq analysis of human retinas uncovered harmonin_a1 as the most abundant transcript of USH1C. Bulk RNA-seq…
Directly proving the bosonic nature of photons
2021
A simple yet effective optical set-up, employing two controllable, indistinguishable photons, is proven to allow a direct measurement of the exchange phase due to the bosonic particle statistics.
Adaptive response to wine selective pressures shapes the genome of a Saccharomyces interspecies hybrid
2021
During industrial processes, yeasts are exposed to harsh conditions, which eventually lead to adaptation of the strains. In the laboratory, it is possible to use experimental evolution to link the evolutionary biology response to these adaptation pressures for the industrial improvement of a specific yeast strain. In this work, we aimed to study the adaptation of a wine industrial yeast in stress conditions of the high ethanol concentrations present in stopped fermentations and secondary fermentations in the processes of champagne production. We used a commercial Saccharomyces cerevisiae × S. uvarum hybrid and assessed its adaptation in a modified synthetic must (M-SM) containing high ethan…
LTE-based passive radars and applications: a review
2021
This paper provides an overview of the most recent passive radars based on long-term evolution (LTE). To begin, this paper investigates the various characteristics and requirements of 4 G LTE signals for radar, taking performance aspects such as range, velocity, range resolution, and velocity resolution into account. An ambiguity function analysis is performed on a measured LTE signal using the synchronization and reference signal components to evaluate key performance parameters such as Doppler and range characteristics. We also discuss how LTE passive radar can be used in a variety of applications. The detailed analysis of the LTE downlink signal, its structural overview, and the effect o…
Sources of nitrous oxide and fate of mineral nitrogen in sub-Arctic permafrost peat soils
2021
Nitrous oxide (N2O) emissions from permafrost-affected terrestrial ecosystems have received little attention, largely because they have been thought to be negligible. Recent studies, however, have shown that there are habitats in subarctic tundra emitting N2O at high rates, such as bare peat surfaces on permafrost peatlands. The processes behind N2O production in these high-emitting habitats are, however, poorly understood. In this study, we established an in situ 15N-labelling experiment with the main objectives to partition the microbial sources of N2O emitted from bare peat surfaces (BP) on permafrost peatlands and to study the fate of ammonium and nitrate in these soils and in adjacent …
Front Cover: (Photo)electrocatalytic Versus Heterogeneous Photocatalytic Carbon Dioxide Reduction (ChemPhotoChem 9/2021)
2021
Transcriptomic Changes Following Partial Depletion of CENP-E in Normal Human Fibroblasts
2021
The centromere is a fundamental chromosome structure in which the macro-molecular kinetochore assembles and is bound by spindle microtubules, allowing the segregation of sister chromatids during mitosis. Any alterations in kinetochore assembly or functioning or kinetochore–microtubule attachments jeopardize chromosome stability, leading to aneuploidy, a common feature of cancer cells. The spindle assembly checkpoint (SAC) supervises this process, ensuring a faithful segregation of chromosomes. CENP-E is both a protein of the kinetochore and a crucial component of the SAC required for kinetochore–microtubule capture and stable attachment, as well as congression of chromosomes to the metaphas…
Old Intraterminals: Aorists
2021
A paradigm of extreme rainfall pluvial floods in complex urban areas: the flood event of 15 July 2020 in Palermo (Italy)
2021
Abstract. In the last few years, some regions of the Mediterranean area have witnessed a progressive increase in extreme events, such as urban and flash floods, as a response to the increasingly frequent and severe extreme rainfall events, which are often exacerbated by the ever-growing urbanization. In such a context, the urban drainage systems may not be sufficient to convey the rainwater, thus increasing the risk deriving from the occurrence of such events. This study focuses on a particularly intense urban flood that occurred in Palermo (Italy) on 15 July 2020; it represents a typical pluvial flood due to extreme rainfall on a complex urban area that many cities have experienced in rece…
The Turkic Language Family
2021
L-citrulline ameliorates pathophysiology in a rat model of superimposed preeclampsia
2021
AbstractPreeclampsia, characterized by hypertension, proteinuria, and fetal growth restriction, is one of the leading causes of maternal and perinatal mortality. By far, there is no effective pharmacological therapy for preeclampsia. The present study was conducted to investigate the effects of L-citrulline supplementation in Dahl salt-sensitive rat, a model of superimposed preeclampsia. Parental DSSR were treated with L-citrulline (2.5 g/L in drinking water) from the day of mating to the end of lactation period. Blood pressure of the rats was monitored throughout pregnancy and markers of preeclampsia were assessed. Endothelial function of the pregnant DSSR was assessed by wire myograph. L-…
From Buildings' End of Life to Aggregate Recycling under a Circular Economic Perspective: A Comparative Life Cycle Assessment Case Study
2021
The demolition of buildings, apart from being energy intensive and disruptive, inevitably produces construction and demolition waste (C&Dw). Unfortunately, even today, the majority of this waste ends up underexploited and not considered as valuable resources to be re-circulated into a closed/open loop process under the umbrella of circular economy (CE). Considering the amount of virgin aggregates needed in civil engineering applications, C&Dw can act as sustainable catalyst towards the preservation of natural resources and the shift towards a CE. This study completes current research by presenting a life cycle inventory compilation and life cycle assessment case study of two buildin…
Polysyllabic Word Forms
2021
Précis de fiscalité des entreprises : 2021/2022
2021
International audience
Letter to the Editor: Comment on “The Application of Artificial Intelligence for the Diagnosis and Treatment of Liver Diseases”
2021
among the forthcoming articles to be published in Hepatology, I noticed the extensive review by Ahn, Connell, Simonetto, Hughes & Shah concerning "The application of artificial intelligence for the diagnosis and treatment of liver diseases" [1]. As a bioethicist, I need to raise some concern about the perspective given by this review, which disregards some important issues concerning ethical aspects and patient-physician relationship.
Index of languages and dialects
2021
Development of accelerometer-based light to vigorous physical activity in fitness profiles of school-aged children.
2021
This study examined the developmental trajectories of light (LPA) and moderate-to-vigorous physical activity (MVPA) in fitness profiles derived from motor competence, perceived motor competence, health-related fitness, and MVPA behaviour. Locomotor, stability, and object-control skills, muscular and cardiovascular fitness, and physical activity were assessed in 510 (girls 285, boys 225) Finnish school-aged children (Mage = 11.26 ± .33 years) over three years. Physical activity was measured using hip-mounted accelerometers. Fitness profiles were identified using latent profile analysis and the development of physical activity levels across four assessments was analysed with latent growth cur…
Above the Sentence Level
2021
Energy dependence of ϕ meson production at forward rapidity in pp collisions at the LHC
2021
The production of $ϕ$ mesons has been studied in pp collisions at LHC energies with the ALICE detector via the dimuon decay channel in the rapidity region $2.5 < y < 4$. Measurements of the differential cross section ${\rm d}^2σ/{\rm d}y {\rm d}p_{\rm T}$ are presented as a function of the transverse momentum ($p_{\rm T}$) at the center-of-mass energies $\sqrt{s}=5.02$, 8 and 13 TeV and compared with the ALICE results at midrapidity. The differential cross sections at $\sqrt{s}=5.02$ and 13 TeV are also studied in several rapidity intervals as a function of $p_{\rm T}$, and as a function of rapidity in three $p_{\rm T}$ intervals. A hardening of the $p_{\rm T}$-differential cross sect…
Phonemes in Prime Syllables
2021
Expanding the phenotype of ASXL3 ‐related syndrome: A comprehensive description of 45 unpublished individuals with inherited and de novo pathogenic v…
2021
The study aimed at widening the clinical and genetic spectrum of ASXL3-related syndrome, a neurodevelopmental disorder, caused by truncating variants in the ASXL3 gene. In this international collaborative study, we have undertaken a detailed clinical and molecular analysis of 45 previously unpublished individuals with ASXL3-related syndrome, as well as a review of all previously published individuals. We have reviewed the rather limited functional characterization of pathogenic variants in ASXL3 and discuss current understanding of the consequences of the different ASXL3 variants. In this comprehensive analysis of ASXL3-related syndrome, we define its natural history and clinical evolution …