showing 36 of ~574560 from 574555 documents
Regulatory network analysis in estradiol-treated human endothelial cells.
2021
Background/Aims: Estrogen has been reported to have beneficial effects on vascular biology through direct actions on endothelium. Together with transcription factors, miRNAs are the major drivers of gene expression and signaling networks. The objective of this study was to identify a com-prehensive regulatory network (miRNA-transcription factor-downstream genes) that controls the transcriptomic changes observed in endothelial cells exposed to estradiol. Methods: miR-NA/mRNA interactions were assembled using our previous microarray data of human umbilical vein endothelial cells (HUVEC) treated with 17ß- Estradiol (E2) (1 nmol/lL, 24 h). miRNA--mRNA pairings and their associated canonical pat…
Ion mobility mass spectrometry – an efficient tool for the analysis of conformational switch of macrocyclic receptors upon anion binding
2021
Interactions between anions and synthetic macrocyclic receptors belong to the extensively explored area of research due to the particularly important functions of anions in biological and environmental sciences. Structures of anion-macrocycle complexes are closely related to their function, highlighting the importance of structural analysis of the complexes. Here, we discuss the application of ion mobility mass spectrometry (IM-MS) and theoretical calculations to the structural analysis of tetralactam macrocycles (M) with varying flexibility and structural properties, and their complexes with anions [M + X]−. Collision cross section (CCS) values obtained from both direct drift tube (DT) and…
En busca de textualidades críticas. Ortodoxia memorial y campo literario
2021
Challenges on accessing finance for micro-enterprises in Latvia
2021
Financial support of companies for their development is considered and realised by many countries worldwide, also in Latvia. Latvia has been receiving critical remarks from entrepreneurs in regard to high level of refuse for financing from the financing institution ALTUM which is the principal intermediary of EU funds and provides resources to support entrepreneurship in Latvia. Statistical data indicate that there are significant reductions of micro-enterprises during recent years. The survey data showed that ALTUM rejected 39 % of the surveyed micro-enterprises from those who had submitted applications within three years. In turn, only 6 % of micro-enterprises have received full financing…
Studying neutrinos at the LHC: FASER and its impact to the cosmic-ray physics
2021
Studies of high energy proton interactions have been basic inputs to understand the cosmic-ray spectra observed on the earth. Yet, the experimental knowledge with controlled beams has been limited. In fact, uncertainties of the forward hadron production are very large due to the lack of experimental data. The FASER experiment is proposed to measure particles, such as neutrinos and hypothetical dark-sector particles, at the forward location of the 14 TeV proton-proton collisions at the LHC. As it corresponds to 100-PeV proton interactions in fixed target mode, a precise measurement by FASER would provide information relevant for PeV-scale cosmic rays. By studying three flavor neutrinos with …
Combined Anchoring: Prosecution and defense claims as sequential anchors in the courtroom
2021
Purpose When making judgements under uncertainty not only lay people but also professional judges often rely on heuristics like a numerical anchor (e.g., a numerical sentencing demand) to generate a numerical response. As the prosecution has the privilege to present its demand first, some scholars have speculated about an anchoring���based unfair disadvantage for the defence (who has the last albeit less effective word in court). Despite the plausibility of this reasoning, it is based on a hitherto untested assumption that the first of two sequential anchors exerts a greater influence on a later judgement (a primacy effect). We argue that it is also conceivable that the last word in court h…
“Lo que está en juego es un pulso libertario que hace converger la cuestión de la teoría crítica y la práctica textual, lo poético y lo político en u…
2021
En la siguiente entrevista, Antonio Méndez Rubio reflexiona sobre los hitos de su pensamiento literario, teórico y cultural. En diálogo con Raúl Molina Gil, aborda cuestiones como la relación entre poética y Teoría, la necesidad de que la crítica permita atravesar lo aparente para dar cuenta de lo ocultado, la voluntad de establecer una mirada necesariamente anti-fascista o las diferencias entre España y Latinoamérica en lo referente a la lectura y aplicación de la Teoría. Todo ello, a partir de los términos e ideas más relevantes que ha planteado a lo largo de sus ensayos como, por ejemplo, el fascismo de baja intensidad.
Action-Depicting Gestures and Morphosyntax: The Function of Gesture-Speech Alignment in the Conversational Turn
2021
The current study examines the role of action-depicting gestures in conversational turns by focusing on their semantic characteristics and temporal position in relation to their verbal affiliates (action verbs or more complex verb phrases). The data are video recordings of naturally occurring interactions in multilingual construction sites in Norway. The analysis distinguishes two modes of action depiction: generic depictions, which represent the action as a general type, and contextualized depictions, which in addition include deictic references to the spatio-material environment or iconic representations of the specific manner of action performance. These two modes typically occupy differ…
Ein neues Fragment des Midrasch Bereschit Rabba
2021
Unter den in Archiven und Bibliotheken erhaltenen Einband- und Makulaturfragmenten bilden die auf Hebräisch beschrifteten Reste jüdischer Handschriften eine besondere Gruppe. Die Erforschung dieser jüdischen Fragmente erfährt seit einigen Jahren in Deutschland und auch in benachbarten europäischen Ländern zunehmende Beachtung. Dennoch sind viele Funde noch unbekannt und konnten daher etwa auch im Rahmen größerer Editionsprojekte nicht berücksichtigt werden. Ihre systematische Erfassung stellt daher nach wie vor eine wichtige Aufgabe dar und wird auch in den kommenden Jahren immer wieder interessante Entdeckungen auch an entlegenen Orten zu Tage fördern. Das hier vorgestellte Blatt wurde unl…
Landscape management and economic evaluation of the ecosystem services of the vineyards
2021
<abstract> <p>The contribution aims to highlight the relationship between the business economy applied to viticulture and the ecosystem. The concepts of ecosystem services and viticultural biodiversity are seen in order to provide a new perspective for the development of a more sustainable business management. The work contributes to enriching the economic literature by introducing the relationship between ecosystem and business. The new perspective helps to place the company within the wider ecological-social system, favoring a more consistent interpretation of the relationship of exchange (impact and dependence) of resources with nature. The work proposes a methodology for cal…
Imaging and Ion-Beam Milling of Biological Specimens with the Helium-Ion Microscope
2021
Last glacial millennial-scale hydro-climate and temperature changes in Puerto Rico constrained by speleothem fluid inclusion δ&lt;sup&gt;18&a…
2021
Abstract. We present speleothem fluid inclusion δ18Of and δ2Hf values from Larga Cave, Puerto Rico, that covers the interval between 46.2 to 15.3 ka before present on millennial scale, including the Last Glacial Maximum (LGM) and several stadial and interstadial cycles. The dataset can be divided in two main clusters of stable isotope compositions of the fluid inclusion water with respect to the global meteoric water line which coincide with strong variations in the water content of the stalagmite. In particular, this clustering is found to be climate related, where the first cluster comprises samples from cold and dry periods, such as Heinrich and Greenland stadials, as well as parts of th…
Genetic association study of childhood aggression across raters, instruments, and age
2021
AbstractChildhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assessors were included. We analyzed phenotype assessments for a total of 328 935 observations from 87 485 children aged between 1.5 and 18 years, while accounting for sample overlap. We also meta-analyzed within subsets of the data, i.e., within rater, instrument and age. SNP-heritability for the overall meta-analysis (AGGoverall) was 3.31% (SE = 0.0038). We found no genome-wide significant SNPs for AGGoverall. The gene-based analysis returned three sign…
Preoperative Evaluation and Treatment Planning. Zygomatic Implant Critical Zone (ZICZ) Location
2021
Horizontally transmitted parasitoid killing factor shapes insect defense to parasitoids
2021
Protection from parasitism by a virus Parasitoid wasps have developed myriad systems to overcome the defense mechanisms of their hosts as they lay their eggs in the bodies and eggs of targeted species. Gasmi et al . report how the host can fight back when infected by a virus that expresses a protein conferring resistance to the parasitoid. When members of the butterfly and moth family are targeted by wasps, a protein family has evolved that is horizontally carried by viruses—and sometimes is incorporated into the host genome—and impairs the ability of parasitoid offspring to fully develop and emerge. Characterizing the ability of this protein to protect hosts against specific parasites, the…
Ciudadanía y transformación social: Nuevos discursos y acción contra el cambio climático
2021
El canvi climatic protagonitza el debat mediambiental des de fa tres decades. Malgrat els acords internacionals adoptats, la humanitat no ha aconseguit frenar l’augment de la temperatura planetaria. La crisi del coronavirus ha relegat el debat sobre l’emergencia climatica a un segon pla, encara que les connexions entre canvi climatic i pandemia demostren les multiples raons que tenim per a actuar pel clima. Les politiques publiques han afavorit regulacions, instruments de mercat i estrategies de modernitzacio ecologica que consoliden un capitalisme verd que agreuja el problema i el despolititza. La lluita contra el canvi climatic necessita un nou enfocament, basat en la politica ciutadana i…
Alveolar bone height and thickness assessed by CBCT
2021
Abstract Objectives To seek information regarding the relationship between the quantity of alveolar bone and the angle and sagittal position of the incisors. This was to be further determined in relation to the basal bones and facial pattern with the aim of establishing a predictive model based on the study of a lateral cephalogram. Methods The distance from the cemento-enamel junction to the labial alveolar crest and the bone thickness half-way along the root of the most prominent upper and lower incisor were measured in a sample of 100 cone beam computed tomography (CBCT) scans of patients aged between 15 and 34 years. Lateral cephalograms of the patients were extracted from the scans and…
Toward Parametrization of Precipitating Shallow Cumulus Cloud Organization via Moisture Variance
2021
The influence of the initial vertical moisture profile on precipitating shallow cumulus cloud organization in terms of the column‐averaged moisture variance is investigated using large‐eddy simulations. Five idealized simulations based on the Rain in Cumulus over the Ocean field experiment with different initial moisture profiles are investigated. All cases simulate precipitating shallow cumulus convection in a marine sub‐tropical region under large‐scale subsidence. The results show that the moisture variance is mainly generated through the interaction of the moisture flux and the moisture gradient in the gradient production term at the top of the boundary layer. The development is charact…
Phytocystatin CsinCPI-2 Reduces Osteoclastogenesis and Alveolar Bone Loss
2021
Made available in DSpace on 2022-04-28T19:42:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-02-01 Periodontal disease (PD) is a polymicrobial chronic inflammatory condition of the supporting tissues around the teeth, leading to the destruction of surrounding connective tissue. During the progression of PD, osteoclasts play a crucial role in the resorption of alveolar bone that eventually leads to the loss of teeth if the PD is left untreated. Therefore, the development of antiresorptive therapies targeting bone-resorbing cells will significantly benefit the treatment of PD. Here, we demonstrate the inhibitory effect of CsinCPI-2, a novel cysteine peptidase inhibitor from the oran…
A Form for Writing 20th Century Loss: Aesthetics of Absence in Virginia Woolf’s Jacob’s Room
2021
Considerada la seva primera novel·la modernista, Jacob’s Room (1922) de Virginia Woolf seria recordada per les seves tecniques experimentals per a contar la historia de Jacob, qui va morir a la Primera Guerra Mundial. La construccio del que es en el fons del seu personatge mes misterios ofereix una resposta diferent a les realitats canviants de la guerra i serveix com manera literaria de dol que busca no tant consolar com preservar i transmetre l’absencia provocada per les perdues de la Gran Guerra. Aqui es presenta una analisis de l’estetica de l’absencia a l’obra de Woolf, i s’afirma que anticipa preocupacions posteriors al tractar experiencies de violencia de masses en la literatura. De …
How Correlated Are Community-Aware and Classical Centrality Measures in Complex Networks?
2021
Unlike classical centrality measures, recently developed community-aware centrality measures use a network’s community structure to identify influential nodes in complex networks. This paper investigates their relationship on a set of fifty real-world networks originating from various domains. Results show that classical and community-aware centrality measures generally exhibit low to medium correlation values. These results are consistent across networks. Transitivity and efficiency are the most influential macroscopic network features driving the correlation variation between classical and community-aware centrality measures. Additionally, the mixing parameter, the modularity, and the Max…
Presepsin value predicts the risk of developing severe/critical COVID-19 illness: results of a pooled analysis
2021
Single-cell RNA sequencing of SARS-CoV-2 cell entry factors in the preconceptional human endometrium.
2021
Abstract STUDY QUESTION Are SARS-CoV-2 canonical cell entry machinery, consisting of ACE2, TMPRSS2, NRP1 and LY6E, or alternative potential cell entry machinery, consisting of BSG, ANPEP, CD209, CLEC4G, TMPRSS4, TMPRSS11A, FURIN, CTSB, CTSL and IFITM1, expressed in the human endometrium across the menstrual cycle? SUMMARY ANSWER Analysis of cell entry factors for SARS-CoV-2 by single-cell RNA-sequencing (scRNAseq) in the preconceptional human endometrium reveals low risk of infection. WHAT IS KNOWN ALREADY Gene expression datasets from bulk endometrial tissue show no significant expression of the SARS-CoV-2 receptor ACE2 and TMPRSS2. This is in contrast to reported expression of ACE2 at the…
La vía cultural al socialismo. Políticas de la cultura en el Chile de la Unidad Popular
2021
El 4 de septiembre de 2020 se cumplieron cincuenta anos del historico triunfo de la Unidad Popular en Chile. Unos meses antes, en octubre de 2019, el pais se vio sacudido por una movilizacion social y popular que parecia carecer de precedentes cercanos, cuya magnitud recordaba a las grandes movilizaciones de principios de los anos setenta. La vinculacion no se acababa ahi: el estallido social de octubre trataba de impugnar los marcos ideologicos, economicos y vitales construidos en la dictadura de Pinochet y con-solidado en los largos anos de la postdictadura. Y para ello, reconocia en los simbolos culturales del periodo de la UP una posible genealogia: las multiples reinterpretaciones de “…
Development and Initial Validation of the Humor Climate in Sport Scale
2021
In sport teams, humor is an essential element that influences communication processes, and plays an important role in group dynamics. Despite this, no current instrument is presented in the literature to measure humor climate in sport teams. Therefore, the current study presents the development and initial validation of the Humor Climate in Sport Scale (HCSS). The aim was to assess content, structural and concurrent validity of the developed instrument, and to examine differential item functioning (DIF) as a function of sex. Three different phases were completed in this study. The first phase involved focus groups (n= 5) that explored humor as communication in a team sport context. In phase…
Neutron excitations in Ba119
2021
The Dual/Global Value of SARS-CoV-2 Genome Surveillance on Migrants Arriving to Europe via the Mediterranean Routes.
2021
Despite the pandemic, 34,154 migrants, refugees or asylum-seekers landed in Sicily (Italy) in 2020, representing the main point of entry by sea into Europe. The SARS-CoV-2 surveillance program among migrants arriving to Sicily via the Mediterranean Sea, made by the combination of clinical examination and molecular testing, has been integrated by full-genome sequencing strains using the NGS technology from the last week of February. To date, more than one hundred full-genome strains have been sequenced and 8 different lineages have been identified mostly belonging to the lineages B.1.1.7 and B.1.525. As global access to COVID-19 vaccines should be ensured, the need to provide more detailed i…
Development and Initial Validation of the Humor Climate in Sport Scale Running Head: Humor climate in sport
2021
In sport teams, humor is an essential element that influences communication processes, and plays an important role in group dynamics. Despite this, no current instrument is presented in the literature to measure humor climate in sport teams. Therefore, the current study presents the development and initial validation of the Humor Climate in Sport Scale (HCSS). The aim was to assess content, structural and concurrent validity of the developed instrument, and to examine differential item functioning (DIF) as a function of sex. Three different phases were completed in this study. The first phase involved focus groups (n = 5) that explored humor as communication in a team sport context. In phas…
Assessment of Benefits and Risks of Probiotics in Processed Cereal-based Baby Foods Lactobacillus Paracasei ssp. Paracasei F19
2021
The Norwegian Scientific Committee for Food Safety (VKM) has appointed an ad hoc-group of experts to answer a request from the Norwegian Food Safety Authority regarding benefit and risk assessment of Lactobacillus paracasei ssp. paracasei F19 (F19) in processed cerealbased baby foods intended for small children 1-3 years. This assessment is based on the literature provided by the notifier as well as that found by a MEDLINE search. 
 
 A notification regarding two products of processed cereal-based baby foods (hereafter called cereals), intended for small children and supplemented with the bacterium F19 initiated this work.
 
 A daily supply of a monoculture of a partic…
6H9Y
2021
unraveling the role of the secretor antigen in human rotavirus attachment to histo-blood group antigens
2021
New insight into the aptamer conformation and aptamer/protein interaction by surface-enhanced Raman scattering and multivariate statistical analysis
2021
International audience; We study the interaction between one aptamer and its analyte (the MnSOD protein) by the combination of surface-enhanced Raman scattering and multivariate statistical analysis. We observe the aptamer structure and its evolution during the interaction under different experimental conditions (in air or in buffer). Through the spectral treatment by principal component analysis of a large set of SERS data, we were able to probe the aptamer conformations and orientations relative to the surface assuming that the in-plane nucleoside modes are selectively enhanced. We demonstrate that the aptamer orientation and thus its flexibility rely strongly on the presence of a spacer …
ROMÁN, Gloria, Franquismo de carne y hueso. Entre el consentimiento y las resistencias cotidianas (1939-1975). Publicacions de la Universitat de Valè…
2021
Reseña: ROMÁN, Gloria, Franquismo de carne y hueso. Entre el consentimiento y las resistencias cotidianas (1939-1975). Publicacions de la Universitat de València, Valencia, 2020, ISBN: 978-84-9134-712-5, 380 pp.
Decisiones administrativas automatizadas en materia social: algoritmos en la gestión de la Seguridad Social y en el procedimiento sancionador
2021
El recientemente aprobado Real Decreto-Ley 2/2021 extiende el campo de las actuaciones administrativas automatizadas a la mayor parte de la gestión de la Seguridad Social y las introduce en el procedimiento sancionador en el orden social. En este nuevo contexto, se intenta contextualizar estas novedades, analizando sus precedentes, y, sobre todo, determinar los problemas interpretativos que plantean. En este último terreno, se dispensa una atención especial a las garantías que los ciudadanos tienen en relación con este tipo de decisiones automatizadas
Determinants of Individual Knowledge Innovation Behavior
2021
With the upsurge of "emotional storm" in the field of organizational behavior, the studies on individual emotions in organizational context are rising. Especially the relationship between emotions and knowledge innovation has attracted much attention by scholars. In particular, individual emotions may exert great effect on knowledge innovation whereas the mechanism is still unclear. Based on the emotional event theory, this paper constructs a model which explores the interaction of positive and negative emotions with individual knowledge innovation. Based on questionnaire data analysis, the results show that knowledge sharing partly mediate the relationship between positive emotion and know…
Thinking the Political with Jean-Luc Nancy
2021
In this article, I argue that at the center of Jean-Luc Nancy’s approach to the political lies the thinking of subject as that of relation. Throughout the historical actualizations of, for example, the individual, the state, or the people as a subject, the problematic of relation is one that has retreated and now demands to be subjected to a retreatment. When the arche-teleological presuppositions that constitute subject as that which is given enter the phase of deconstruction, subject comes to present itself as nothing but the activity of relating itself to itself. I respond to Nancy’s call to invent “an affirmation of relation” by way of rethinking the logics of sovereignty and democracy.…