Influence of systemic strontium ranelate on the progression and as adjunctive therapy for the nonsurgical treatment of experimental periodontitis

2021

Made available in DSpace on 2022-05-01T11:39:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Universidade Estadual Paulista Background: Strontium Ranelate (SR) presents overlapping osteoanabolic and anti-resorptive activity. However, the effects of SR on the progression of periodontitis through the alveolar bone and its potential applicability as adjunctive therapy to scaling and root planning remain poorly accessed. The aim of this study was to evaluate the effects of systemic (SR) both on the progression of experimental periodontitis (EP) and as adjunctive therapy to SRP. Material and Methods: Eighty male rats were divided into four groups (n=20): EP-PSS: EP induction and …

A Trusted Hybrid Learning Approach to Secure Edge Computing

2021

Securing edge computing has drawn much attention due to the vital role of edge computing in Fifth Generation (5G) wireless networks. Artificial Intelligence (AI) has been adopted to protect networks against attackers targeting the connected edge devices or the wireless channel. However, the proposed detection mechanisms could generate a high false detection rate, especially against unknown attacks defined as zero-day threats. Thereby, we propose and conceive a new hybrid learning security framework that combines the expertise of security experts and the strength of machine learning to protect the edge computing network from known and unknown attacks, while minimizing the false detection rat…

Solid ground makes solid understandings: does simple comparison paves the way for more complex comparisons ?

2021

In this experiment, we investigated the role of dimensional distinctiveness on the generalization of novel names for unfamiliar objects. In a comparison design, we manipulated the sequence of trials difficulty, starting either with more difficult trials or with easier trials. To achieve this, we manipulated the dimensional distinctiveness of the first comparison trials and of the, later, transfer trials. Results showed that high-distinctiveness (easy) stimuli increased children’s later performance in the low-distinctiveness (difficult) condition whereas low-distinctiveness early training led to no later improvement in easier trials. Last, a correct answer for the first trial in the first le…

Autologous Platelet-Rich Plasma in the treatment of androgenetic alopecia: results of a 54-patient prospective study

2021

The current medical treatments of androgenetic alopecia (AGA) have hardly achieved a satisfying clinical improvement. Biologic regenerative therapies, such as platelet-rich plasma (PRP) injections in the scalp, have been proposed recently. This multidisciplinary prospective study aims to explore the efficacy and safety of autologous PRP injections into the scalp of patients with AGA. Fifty-four patients with AGA (35 men and 19 women) were enrolled. Non-activated autologous PRP was injected into the androgen-related areas of the scalp. The study protocol consisted of three sessions of injections at 3-month interval. The effects were assessed by means of noninvasive methods. Safety profile, p…

Entre vin étrusque et vin grec : les métamorphoses de Dionysos sur une hydrie du Peintre de Micali

2021

The purpose of this contribution is to re-examine the iconography of an Etruscan hydria by the Micali Painter, probably the most famous craftsman of the black-figure ceramics technique at the end of the 6th century B.C. In our opinion, this vase would present the Etruscan version of a Greek myth showing the ancient Tuscans as pirates attempting to kidnap Dionysus. This figuration, which also appears in Greek sources, could be interpreted as the rivalry between the two cultures for the control of the wine trade in the western part of the Mediterranean. However, we will ask ourselves whether the iconography of this vase should be interpreted in the sense of a negative image of the Etruscans, …

Le “plaisir sucré” de la duchesse : un point sur la production du « galant de Madame » à la fin du Moyen Âge. https://preo.u-bourgogne.fr/crescentis/…

2021

Among the range of products elaborated in the Dukes of Burgundy vineyards at the end of the Middle Ages, the galant is first quoted in 1383. This paper strives to shed new light upon the sources in which the galant appears, i.e. the accountability documentation of the Dukes’ vineyards. Our research focuses on two demesnes located near Dijon: Talant and Chenôve.The study of this rare product (2-4% of total production), which was certainly flavored with gentian, shows that the notion of fortified wine should be reconsidered for the 14th and 15th centuries. The galant was obtained only by heating white grape must in a cauldron, searching to reach a diminution of one- or two-thirds of the basic…

Validación de contenidos de educación para el desarrollo para el análisis de manuales escolares

2021

INTRODUCCIÓN. En un mundo globalizado marcado por las grandes desigualdades económicas y la falta de acceso universal a la educación y la sanidad de calidad, es necesario trabajar desde la educación escolar contenidos que visibilicen, sensibilicen y den a conocer al alumnado la realidad mundial en la que cohabitan. La Educación para el Desarrollo es una perspectiva de gran valor para abordar esta temática en el espacio escolar en la formación de valores ciudadanos. MÉTODO. A partir de la revisión de documentos de referencia a nivel internacional y nacional, se presenta un listado inicial de contenidos de Educación para el Desarrollo que son validados a través de un proceso de juicio desde l…

Machine learning: A modern approach to pediatric asthma

2021

Among modern methods of statistical and computational analysis, the application of machine learning (ML) to healthcare data has been gaining recognition in helping us understand the heterogeneity of asthma and predicting its progression. In pediatric research, ML approaches may provide rapid advances in uncovering asthma phenotypes with potential translational impact in clinical practice. Also, several accurate models to predict asthma and its progression have been developed using ML. Here, we provide a brief overview of ML approaches recently proposed to characterize pediatric asthma.

Oxidation effects in antiaggregogenic properties of Epigallocatechingallate

2021

Epigallocatechin-gallate (EGCG), the most abundant flavonoid in green tea, has been extensively studied for its potential in the treatment of amyloid related disorders. This molecule was found to modulate abnormal protein self-assembly, reducing resulting cellular toxicity. EGCG is known to suppress or to slow down the aggregation processes of several proteins, thus supporting the idea that general mechanisms regulate its anti-aggregogenic effects and, interestingly, in the oxidised form it demonstrated an higher efficiency in reducing protein aggregation with respect to intact molecule. We here investigate the effects of intact and oxidized EGCG the thermal aggregation pathway of Bovine Se…

Understanding the inward emotion-focused coping strategies of individual users in response to mobile malware threats

2021

According to coping theory, individuals cope with information system threats by adopting either problem-focused coping (PFC) or emotion-focused coping (EFC). However, little is known about EFC in the information security (ISec) literature. Moreover, there is potential confusion regarding the meaning of some EFC strategies. Hence, ISec scholars and practitioners may (i) have a narrow view of EFC or (ii) confuse it with other concepts. In this study, we offer one response to this issue. We first address the ambiguity regarding EFC before differentiating five inward EFC strategies and assessing them empirically in the mobile malware context. To the best of our knowledge, this study is the firs…

Disrupted PGR-B and ESR1 signaling underlies preconceptional defective decidualization linked to severe preeclampsia

2021

AbstractDecidualization of the uterine mucosa drives the maternal adaptation to invasion by the placenta. Appropriate depth of placental invasion is needed to support a healthy pregnancy; shallow invasion is associated with the development of severe preeclampsia (sPE). Maternal contribution to sPE through failed decidualization is an important determinant of placental phenotype. However, the molecular mechanism underlaying the in vivo defect linking decidualization to sPE is unknown. Here, we discover the footprint encoding this decidualization defect comprising of 166 genes using global gene expression profiling in decidua from women who developed sPE in a previous pregnancy. This signatur…

Al driven peculiarities of local coordination and magnetic properties in single phase Alx CrFeCoNi high entropy alloys

2021

The authors thank the Helmholtz-Zentrum Berlin for the provision of access to synchrotron radiation facilities and allocation of synchrotron radiation at the PM2-VEKMAG, BAMline, and UE46_PGM-1 beamlines of BESSY II at HZB as well as measurement time for magnetometry at HZB CoreLab for Quantum Materials. A. S. acknowledges personal funding from CALIPSOplus project (the Grant Agreement no. 730872 from the EU Framework Programme for Research and Innovation HORIZON 2020). The financial support for the VEKMAG project and the PM2-VEKMAG beamline by the German Federal Ministry for Education and Research (Nos. BMBF 05K10PC2, 05K10WR1, 05K10KE1) and by HZB is cordially acknowledged by all co-author…

piRNAclusterDB 2.0: update and expansion of the piRNA cluster database.

2021

Abstract PIWI-interacting RNAs (piRNAs) and their partnering PIWI proteins defend the animal germline against transposable elements and play a crucial role in fertility. Numerous studies in the past have uncovered many additional functions of the piRNA pathway, including gene regulation, anti-viral defense, and somatic transposon repression. Further, comparative analyses across phylogenetic groups showed that the PIWI/piRNA system evolves rapidly and exhibits great evolutionary plasticity. However, the presence of so-called piRNA clusters as the major source of piRNAs is common to nearly all metazoan species. These genomic piRNA-producing loci are highly divergent across taxa and critically…

Endotyping allergic rhinitis in children: A machine learning approach.

2021

Introduction: The diversity of allergic rhinitis (AR) phenotypes is particularly evident in childhood, suggesting the need to analyze and identify new approaches to capture such clinical heterogeneity. Nasal cytology (NC) is a very useful diagnostic tool for identifying and quantifying nasal inflammation. Data-driven approaches such as latent class analysis (LCA) assign subjects to classes based on their characteristics. We hypothesized that LCA based on NC, including the assessment of neutrophils, eosinophils, and mast cells, may be helpful for identifying AR endotypes in children. Methods: A total of 168 children were enrolled. Sociodemographic characteristics and detailed medical history…

La contrattazione collettiva nazionale di comparto

2021

Il presente lavoro analizza la disciplina della contrattazione collettiva nazionale nel pubblico impiego, con particolare riguardo ai profili evolutivi e giurisprudenziali. The current work analyses the Italian legal framework on national collective bargaining in public administrations, with a specific focus on the historical evolution and judicial orientations.

A genetic approach reveals different modes of action of prefoldins

2021

17 p.-7 fig.

Sobolev homeomorphic extensions

2021

Let $\mathbb X$ and $\mathbb Y$ be $\ell$-connected Jordan domains, $\ell \in \mathbb N$, with rectifiable boundaries in the complex plane. We prove that any boundary homeomorphism $\varphi \colon \partial \mathbb X \to \partial \mathbb Y$ admits a Sobolev homeomorphic extension $h \colon \overline{\mathbb X} \to \overline{\mathbb Y}$ in $W^{1,1} (\mathbb X, \mathbb C)$. If instead $\mathbb X$ has $s$-hyperbolic growth with $s>p-1$, we show the existence of such an extension lies in the Sobolev class $W^{1,p} (\mathbb X, \mathbb C)$ for $p\in (1,2)$. Our examples show that the assumptions of rectifiable boundary and hyperbolic growth cannot be relaxed. We also consider the existence of $W^{…

Binding and Reactivity of a Nitrile Oral Inhibitor of SARS-CoV-2 Main Protease Revealed by Computational Simulations

2021

We present a detailed analysis of the binding mode and reactivity of the novel oral inhibitor PF-07321332 developed against SARS-CoV-2 3CL protease. Classical and QM/MM Molecular Dynamics simulations are used to quantify the contributions to the binding free energy and the reaction mechanism for covalent inhibition. The small size of the nitrile warhead conferes additional advantadges to this inhibitor.

Factores de riesgo y protección del suicidio en personas mayores: una revisión sistemática

2021

La esperanza de vida se ha incrementado notablemente, no obstante, el suicidio es la principal causa de deceso no natural en la población mayor de 70 años. El objetivo de la presente investigación es revisar sistemáticamente los factores de riesgo y protección en la conducta suicida en personas mayores. Se llevó a cabo una revisión sistemática desde el enfoque PRISMA utilizando las bases de datos: PubMed, LILACS, SciELO, Google Académico y Dialnet. Se emplearon distintos descriptores en términos DeCS y MeSH con el operador booleano “AND” y, finalmente, teniendo en cuenta los criterios de inclusión y exclusión, obtuvimos 27 artículos. Los estudios revisados muestran que entre los factores de…

Factors associated with Pneumocystis colonization and circulating genotypes in chronic obstructive pulmonary disease patients with acute exacerbation…

2021

Abstract Pneumocystis jirovecii colonization is frequent during chronic obstructive pulmonary disease (COPD) and patients constitute potential contributors to its interhuman circulation. However, the existence of an environmental reservoir cannot be excluded. We assessed the prevalence and factors associated with Pneumocystis colonization during COPD, and studied circulation between patients and their domestic environment. Pneumocystis molecular detection and mtLSU genotyping were performed in oro-pharyngeal washes (OPW) sampled in 58 patients with COPD acute exacerbation, and in indoor dust, sampled in patients’ homes using electrostatic dust collectors (EDCs). Lung and systemic inflammati…

Unitarity of Minkowski nonlocal theories made explicit

2021

In this work we explicitly show that the perturbative unitarity of analytic infinite derivative (AID) scalar field theories can be achieved using a modified prescription for computing scattering amplitudes. The crux of the new prescription is the analytic continuation of a result obtained in the Euclidean signature to the Minkowski external momenta. We intensively elaborate an example of a non-local $\phi^4$ model for various infinite derivative operators. General UV properties of amplitudes in non-local theories are discussed.

Performance Analysis of Ammonia in Solid Oxide Fuel Cells

2021

The transition of the marine propulsion system towards alternative fuels is mandatory to offset carbon emission. Among the alternative fuels, ammonia is carbon-free and can be produced in sustainable ways. Ammonia has 17.8% hydrogen (wt %) and is easily liquified at 25°C and 8 bar pressure. The two-stroke internal combustion engines currently used in the marine sector reach efficiencies of about 50% but generate substantial polluting emissions. Solid oxide fuel cells generate electricity with efficiencies greater than 50 % and can use ammonia as fuel. In this work, a single-cell SOFC was characterised using in-situ ammonia decomposition reaction (Int-ADR) and compared with ex-situ ammonia …

Mediation of perceived stress and cortisol in the association between neuroticism and global cognition in older adults: A longitudinal study.

2021

Neuroticism has been associated with a greater dementia risk, but its association with cognitive decline in healthy older adults remains unclear. Stress has been proposed as one of the mechanisms that could explain this relationship. Our aim was to analyse, in healthy older people, the mediating role of perceived stress and the Hypothalamic–Pituitary–Adrenal (HPA) axis in the association between neuroticism and global cognition. At Waves 1 and 2 (4-year follow-up), 87 older people (49.4% women; M age = 65.08, SD = 4.54 at Wave 1) completed a neuropsychological battery and the Perceived Stress Scale (PSS), and provided saliva samples on two (Wave 1) and three (Wave 2) consecutive days to mea…

On the occurrence of strong vertical wind shear in the tropopause region: a 10-year ERA5 northern hemispheric study

2021

A climatology of the occurrence of strong wind shear in the upper troposphere–lower stratosphere (UTLS) is presented, which gives rise to defining a tropopause shear layer (TSL). Strong wind shear in the tropopause region is of interest because it can generate turbulence, which can lead to cross-tropopause mixing. The analysis is based on 10 years of daily northern hemispheric ECMWF ERA5 reanalysis data. The vertical extent of the region analyzed is limited to the altitudes from 1.5 km above the surface up to 25 km, to exclude the planetary boundary layer as well as strong wind shear in higher atmospheric layers like the mesosphere–lower thermosphere. A threshold value of St2=4×10-4s-2 of t…

Cyberloafing and cyberslacking in the workplace: systematic literature review of past achievements and future promises

2021

PurposeScholars are increasingly focusing on the adverse effects of digitization on human lives in personal and professional contexts. Cyberloafing is one such effect and digitization-related workplace behavior that has garnered attention in both academic and mainstream media. However, the existing literature is fragmented and needs to be consolidated to generate a comprehensive and contemporary overview of cyberloafing research and map its current intellectual boundaries. The purpose of this paper is to shed some light on systematic literature review (SLR) in cyberloafing and cyberslacking in the workplace.Design/methodology/approachA SLR is conducted to assimilate the existing research. A…

Investigation of the prevalence of impacted third molars and the effects of eruption level and angulation on caries development by panoramic radiogra…

2021

This study is aimed to determine the prevalence of impacted third molars and to investigate the effects of their eruption level and angulation on caries formation in the distal of the adjacent tooth. This cross-sectional study was conducted on panoramic radiographs of 38481 patients who were admitted to the Trakya University, Faculty of Dentistry. The panoramic radiographs of 7998 patients with at least one impacted third molar were included. Third molars were classified according to Winter?s classification and Pell and Gregory?s classification. The frequency of caries in partially impacted third molars and adjacent second molars was determined. The chi-square tests were used to determine p…

Five Roles of Cross-border Cooperation Against Re-bordering

2021

Stable Light-Emitting Electrochemical Cells Using Hyperbranched Polymer Electrolyte

2021

The choice of an adequate electrolyte is a fundamental aspect in polymer light-emitting electrochemical cells (PLECs) as it provides the in situ electrochemical doping and influences the performance of these devices. In this study, a hyperbranched polymer (Hybrane DEO750 8500) blended with a Li salt is used as a novel electrolyte in state-of-the-art Super Yellow (a polyphenylenevinylene) based LECs. Due to the desirable properties of the hyperbranched polymer and the homogeneous and smooth films that it forms with the emitting polymer, PLEC with excellent electroluminescent properties are obtained using a pulsed current bias scheme. The devices are very stable, with lifetimes in excess of 2…

Direct NMR evidence for the dissociation of sulfur-dioxide-bound acetaldehyde under acidic conditions: Impact on wines oxidative stability

2021

Abstract SO2 reaction with electrophilic species present in wine, including in particular carbonyl compounds, is responsible for the reduction of its protective effect during wine aging. In the present study, direct 1H NMR profiling used to monitor the reactivity of SO2 with acetaldehyde under wine-like oxidation conditions. The dissociation of acetaldehyde bound SO2 was evidenced suggesting that released free SO2 can further act as an antioxidant. EPR and DPPH assays showed an increasing antioxidant capacity of wine with the increase in the concentration of acetaldehyde sulfonate. The presence of acetaldehyde sulfonate in wines was correlated with the overall antioxidant activity of wines.…

Selective Actuation and Tomographic Imaging of Swarming Magnetite Nanoparticles

2021

International audience; Micro- and nanomotors have seen substantial progress in recent years for biomedical applications. However, three grand challenges remain: (i) high velocities to overcome the blood flow, (ii) spatially selective control to enable complex navigation, and (iii) integration of a medical, tomographic real-time imaging method to acquire feedback information. Here, we report the combination of active magnetic matter and a medical imaging technique, namely magnetic particle imaging (MPI), which addresses these needs. We synthesize ∼200 nm magnetic nanoparticles and observe a macroscopic, collective effect in a homogeneous magnetic field with a rotating field vector. The nano…

Temperature dependence of spontaneous mutation rates.

2021

Mutation is the source of genetic variation and the fundament of evolution. Temperature has long been suggested to have a direct impact on realized spontaneous mutation rates. If mutation rates vary in response to environmental conditions, such as the variation of the ambient temperature through space and time, they should no longer be described as species-specific constants. By combining mutation accumulation with whole-genome sequencing in a multicellular organism, we provide empirical support to reject the null hypothesis of a constant, temperature-independent mutation rate. Instead, mutation rates depended on temperature in a U-shaped manner with increasing rates toward both temperature…

Prevention of Teratogenesis in Pregnancies of Obese Rats by Vitamin E Supplementation

2021

Congenital malformations are a common adverse outcome in pregnancies complicated by pregestational obesity, although the underlying mechanisms are still unrevealed. Our aim was to study the effect of oxidative stress in obesity-induced teratogenesis. Wistar rats were fed a high-fat diet for 13 weeks, with (OE group) or without (O group) vitamin E supplementation. Then, rats were mated and sacrificed at day 11.5 of gestation. Embryos from O dams presented a 25.9 ± 3.5% rate of malformations (vs. 8.7 ± 3.4% in C rats), which was reduced in the OE group (11.5 ± 2.3%). Pregestational obesity induced hepatic protein and DNA oxidation and a decline in antioxidant enzymes. Importantly, glutathione…

Strongly Red-Emissive Molecular Ruby [Cr(bpmp)2]3+ Surpasses [Ru(bpy)3]2+

2021

Gaining chemical control over the thermodynamics and kinetics of photoexcited states is paramount to an efficient and sustainable utilization of photoactive transition metal complexes in a plethora of technologies. In contrast to energies of charge transfer states described by spatially separated orbitals, the energies of spin-flip states cannot straightforwardly be predicted as Pauli repulsion and the nephelauxetic effect play key roles. Guided by multireference quantum chemical calculations, we report a novel highly luminescent spin-flip emitter with a quantum chemically predicted blue-shifted luminescence. The spin-flip emission band of the chromium complex [Cr(bpmp)2]3+ (bpmp = 2,6-bis(…

Body weight and premature retirement: population-based evidence from Finland.

2021

Abstract Background Health status is a principal determinant of labour market participation. In this study, we examined whether excess weight is associated with withdrawal from the labour market owing to premature retirement. Methods The analyses were based on nationally representative data from Finland over the period 2001–15 (N ∼ 2500). The longitudinal data included objective measures of body weight (i.e. body mass index and waist circumference) linked to register-based information on actual retirement age. The association between the body weight measures and premature retirement was modelled using cubic b-splines via logistic regression. The models accounted for other possible risk fact…

Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma.

2021

Getting around the blood–brain barrier The meninges comprise three membranes that surround and protect the central nervous system (CNS). Recent studies have noted the existence of myeloid cells resident there, but little is known about their ontogeny and function, and whether other meningeal immune cell populations have important roles remains unclear (see the Perspective by Nguyen and Kubes). Cugurra et al. found in mice that a large proportion of continuously replenished myeloid cells in the dura mater are not blood derived, but rather transit from cranial bone marrow through specialized channels. In models of CNS injury and neuroinflammation, the authors demonstrated that these myeloid c…

Estructura bancaria y desigualdad de renta. La banca cooperativa marca la diferencia

2021

En este trabajo se estudia la relación existente entre tres diferentes estructuras bancarias (bancos cooperativos, bancos comerciales y cajas de ahorro) y la desigualdad de renta. El estudio basado en datos panel utiliza modelos estáticos y dinámicos y analiza el conjunto de la Eurozona con un total de 19 países y 2.253 bancos para un periodo temporal comprendido entre 2010 y 2019. Los resultados muestran que solo los bancos cooperativos reducen la desigualdad en contraposición a los bancos comerciales y las cajas de ahorro. Además, estos son robustos entre diferentes metodologías empeladas y utilizando distintos indicadores de desigualdad. Asimismo, los resultados apuntan a que la relación…