showing 36 of ~574560 from 574555 documents
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2021
The COVID-19 pandemic and social distancing measures targeting the transmission of the virus impacted everyday life in 2020. This study investigated pre- to in-pandemic changes in health behaviors and depressive symptoms during the COVID-19 pandemic and the role of personality traits in these changes in Finland. Data from a larger population-based cohort study of 51–59-year-old Finnish women were used (n = 358). Self-reported questionnaires gathered information about depressive symptoms, eating behavior, physical activity, and alcohol consumption before the pandemic time, at the onset, and at the end of the COVID-19 emergency conditions. Information about personality traits (extraversion an…
Les conflits familiaux dans un contexte international
2021
International audience
Workplace bullying, burnout and resilience amongst perioperative nurses in Australia: A descriptive correlational study.
2021
AIM This study aimed to investigate workplace bullying and explore correlations between bullying, burnout and resilience amongst perioperative nurses in Australia. BACKGROUND Workplace bullying in perioperative nursing involves verbal, physical and psychological violence. However, no prior studies have measured Australian perioperative nurses' experiences of workplace bullying nor sought to understand if there is a relationship with burnout and resilience. METHODS A descriptive correlational study was conducted utilizing an online survey incorporating four validated instruments. Descriptive statistics and regression models analysed workplace bullying, burnout and resilience. RESULTS Over ha…
Influence of Substrate Hydrophilicity on Structural Properties of Supported Lipid Systems on Graphene, Graphene Oxides, and Silica
2021
Pristine graphene, a range of graphene oxides, and silica substrates were used to investigate the effect of surface hydrophilicity on supported lipid bilayers by means of all-atom molecular dynamics simulations. Supported 1,2-dioleoyl-sn-glycero-3-phosphocholine lipid bilayers were found in close-contact conformations with hydrophilic substrates with as low as 5% oxidation level, while self-assembled monolayers occur on pure hydrophobic graphene only. Lipids and water at the surface undergo large redistribution to maintain the stability of the supported bilayers. Deposition of bicelles on increasingly hydrophilic substrates shows the continuous process of reshaping of the supported system a…
The Importance of Positive Psychological Strengths in Well-Being and Adjustment of Romanian Emerging Adults: A Pattern and Variable-Oriented Approach
2021
Transition to adulthood in countries that have seen recent historical structural changes in society as well as changes in what it means to be an adult represents important contexts for investigations of ways in which positive development and transition to adulthood are experienced. Situated in such context, this cross-sectional study aimed to (1) describe profiles of positive psychological strengths, as measured by the Five Cs of positive youth development (PYD) and (2) document how identified profiles might differ in relation to other aspects of positive and problematic development. Participants were 272 Romanian emerging adults attending university (76% female; aged 19–29 years old, Mage …
INDAGINE DELLE RELAZIONI FILOGENETICHE INTERNE AI GALERICINAE (EULIPOTYPHLA: ERINACEOMORPHA: ERINACEIDAE), IN PARTICOLARE RIGUARDO AI GENERI ENDEMICI…
2021
Design of a prospective, longitudinal cohort of people living with type 1 diabetes exploring factors associated with the residual cardiovascular risk…
2021
Type 1 diabetes mellitus (T1DM) is associated with a high risk of cardiovascular (CV) complications, even after controlling for traditional CV risk factors. Therefore, determinants of the residual increased CV morbidity and mortality remain to be discovered. This prospective cohort of people living with T1DM in France (SFDT1) will include adults and children aged over six years living with T1DM, recruited throughout metropolitan France and overseas French departments and territories. The primary objective is to better understand the parameters associated with CV complications in T1DM. Clinical data and biobank samples will be collected during routine visits every three years. Data from conn…
Prognostic accuracy of Quick SOFA in older adults hospitalised with community acquired urinary tract infection
2021
Introduction Quick [Sepsis-related] Sequential Organ Failure Assessment (qSOFA) is a prognostic score based on sepsis-3 definition, easy to carry out, whose application has been studied in older adults with sepsis from different sources and respiratory sepsis. However, to date no study has analysed its prognostic accuracy in older adults admitted to hospital with community urinary tract infection. Methods In a prospective study of 282 older adults admitted to hospital with community acquired urinary tract infection, the application of qSOFA to predict hospital mortality was analysed. The predictive capacity of qSOFA for in-hospital mortality was compared with Systemic Inflammatory Response …
Some Notes on Andrapolis, the Royal City: Apocryphal Acts of Thomas 3
2021
The following paper aims to explore the meaning and significance of the so-called royal city Andrapolis (Ἀνδράπολις) within the context of the Apocryphal Acts of Thomas’ s narrative (chapter 3). The identification of this Indian toponym have attracted the attention of many scholars during the last century and nowadays again, as witness of the few reliable historical traces supposedly transmitted by the apocryphal. For doing so, after a short introduction, we deal with the allegedly historicity of the text; then, we focus on the issue related mainly to the different variants of the location depending on the Syriac and Greek versions of the Acts of Thomas, and propose a new interpretatio…
The immunosuppressive activity of artemisinin‐type drugs towards inflammatory and autoimmune diseases
2021
The sesquiterpene lactone artemisinin from Artemisia annua L. is well established for malaria therapy, but its bioactivity spectrum is much broader. In this review, we give a comprehensive and timely overview of the literature regarding the immunosuppressive activity of artemisinin-type compounds toward inflammatory and autoimmune diseases. Numerous receptor-coupled signaling pathways are inhibited by artemisinins, including the receptors for interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α), β3-integrin, or RANKL, toll-like receptors and growth factor receptors. Among the receptor-coupled signal transducers are extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinas…
Conspiracy Beliefs Are Related to the Use of Smartphones behind the Wheel
2021
The belief in conspiracy theories predicts behaviors related to public health such as the willingness to receive vaccines. This study applies a similar approach to an aspect of road safety: the use of smartphones while driving. A representative sample of 1706 subjects answered a series of questions related to what can be regarded as erroneous or conspiracy beliefs against restricting or banning the use of smartphones while driving. The results show that those having such conspiracy beliefs reported a greater use of smartphones behind the wheel.
Situación actual de la investigación en violencia de género en bases de datos nacionales e internacionales. Análisis comparativo y temas dominantes
2021
Tesis doctoral.-- Universidad de Valencia. Programa de doctorado de investigación en psicología. Psicología clínica y de la salud.
Associations of near work time, watching TV, outdoors time, and parents' myopia with myopia among school children based on 38-year-old historical dat…
2021
Purpose To study the prevalence and risk factors of myopia with data from a questionnaire study conducted in 1983 among Finnish school children. Methods School children (n = 4 961) from the 1st, 5th and 8th grades of school (7-, 11- and 15-year-olds) in Central Finland were screened for vision followed by a questionnaire, which was returned by 4 352 (87.7%) participants. Myopia was categorized based on the questionnaire. Items concerned daily time spent on near work and outdoor activities, excluding time spent at school, watching TV and parental myopia and the associations of myopia with these factors were studied. Results The prevalence of myopia was 3%, 15% and 27% among the 7-, 11- and 1…
Primate Jan Wężyk in the Role of Interrex and Senator of the Polish-Lithuanian Commonwealth in the Period of Interregnum Following the Death of Sigis…
2021
Prymas Jan Wężyk w roli interreksa oraz senatora Rzeczypospolitej w okresie bezkrólewia po śmierci Zygmunta III Wazy w 1632 roku
 W Rzeczypospolitej Obojga Narodów prymas, a zarazem arcybiskup gnieźnieński po śmierci monarchy przejmował obowiązki w zakresie reprezentowania państwa na zewnątrz, przygotowywał wybór nowego króla i w tym celu zwoływał sejmiki orz sejm konwokacyjny. Prymas wreszcie ogłaszał wybór elekta, czyli dokonywał nominacji.
 Po śmierci Zygmunta III Wazy w 1632 r. funkcję interreksa w okresie bezkrólewia pełnił prymas Jan Wężyk (1575-1638). Z funkcji tej wywiązał się znakomicie. Sprawowane prze niego urzędy postawiły go w rzędzie osób, które wpływały na kształt R…
Treatment of Hepatocellular Carcinoma with Immune Checkpoint Inhibitors and Applicability of First-Line Atezolizumab/Bevacizumab in a Real-Life Setti…
2021
Immune checkpoint inhibitors (ICIs) are the new frontier for the treatment of advanced hepatocellular carcinoma (HCC). Since the first trial with tremelimumab, a cytotoxic T-lymphocyte-associated protein 4 inhibitor, increasing evidence has confirmed that these drugs can significantly extend the survival of patients with advanced hepatocellular carcinoma (HCC). As a matter of fact, the overall survival and objective response rates reported in patients with advanced HCC treated with ICIs are the highest ever reported in the second-line setting and, most recently, the combination of the anti-programmed death ligand protein-1 atezolizumab with bevacizumab—an anti-vascular endothelial growth fa…
Correction: Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells
2021
High levels of circulating heat shock protein 70 (HSP70) are detected in many cancers. In order to explore the effects of extracellular HSP70 on human microvascular endothelial cells (HMEC), we initially used gap-FRAP technique. Extracellular human HSP70 (rhHSP70), but not rhHSP27, blocks the gap-junction intercellular communication (GJIC) between HMEC, disrupts the structural integrity of HMEC junction plaques, and decreases connexin43 (Cx43) expression, which correlates with the phosphorylation of Cx43 serine residues. Further exploration of these effects identified a rapid transactivation of the Epidermal Growth Factor Receptor in a Toll-Like Receptor 4-dependent manner, preceding its in…
Microbiota Depletion Promotes Human Rotavirus Replication in an Adult Mouse Model
2021
Intestinal microbiota-virus-host interaction has emerged as a key factor in mediating enteric virus pathogenicity. With the aim of analyzing whether human gut bacteria improve the inefficient replication of human rotavirus in mice, we performed fecal microbiota transplant (FMT) with healthy infants as donors in antibiotic-treated mice. We showed that a simple antibiotic treatment, irrespective of FMT, resulted in viral shedding for 6 days after challenge with the human rotavirus G1P[8] genotype Wa strain (RVwa). Rotavirus titers in feces were also significantly higher in antibiotic-treated animals with or without FMT but they were decreased in animals subject to self-FMT, where a partial re…
Perceptions of institutions and social capital accumulation: A social categorization and shared agency‐based approach. Evidence from the Russian Fede…
2021
Barriers to Sport Participation Faced by Ethiopian and Eritrean Migrant Women in Switzerland
2021
Global migration (both forced and voluntary) has intensified the interaction between existing and emerging cultures. Sport has gained recognition as an effective tool for enhancing migrants’ overall wellbeing, active participation, and social integration. However, a growing number of studies have shown that migrant women have the lowest rate of sport participation, especially in organized clubs. These findings have brought the accessibility and inclusion of existing sport structure and culture in host countries into question. Using the six-factor model of constraints by Tsai and Coleman (1999), this study explored the barriers that hinder Ethiopian and Eritrea migrant women (EEMW) from part…
A skeletal Class III malocclusion with agenesis and canine-bicuspid transposition: a nonsurgical approach
2021
Abstract Background The present case report describes the orthodontic management of a patient who presented with a skeletal Class III malocclusion combined with other dental anomalies. The malocclusion was complicated by agenic maxillary lateral incisors and a lower right second premolar, in company with the transposition of the maxillary canines and premolars. Methods Dentoalveolar compensation of the anteroposterior jaw relationship was performed. The upper deciduous lateral incisors were extracted and the spaces closed, so that the first premolars replaced the missing lateral incisors while the canine transposition was maintained Results Satisfactory results were obtained which provided …
Messing Up the Cancer Stem Cell Chemoresistance Mechanisms Supported by Tumor Microenvironment
2021
Despite the recent advances in cancer patient management and in the development of targeted therapies, systemic chemotherapy is currently used as a first-line treatment for many cancer types. After an initial partial response, patients become refractory to standard therapy fostering rapid tumor progression. Compelling evidence highlights that the resistance to chemotherapeutic regimens is a peculiarity of a subpopulation of cancer cells within tumor mass, known as cancer stem cells (CSCs). This cellular compartment is endowed with tumor-initiating and metastasis formation capabilities. CSC chemoresistance is sustained by a plethora of grow factors and cytokines released by neighboring tumor…
Individual and shared digital repertoires – older adults managing digital services
2021
The rise of public and other non-recreational digital services is based on the idea of catering to the daily needs of the citizens cost-efficiently and with ease. Previous research has approached t...
Localizing Global Solidarity: Humanitarian Aid in Lesvos
2021
The so-called “refugee crisis” in Lesvos, Greece provides a poignant example of situated, local suffering that has called for the coordination of global resources to provide relief. Some of the first to respond were local and international Citizen Initiatives for Global Solidarity (CIGS). While a growing role for CIGS has been interpreted as a call for more global involvement, arguments for the increased localization of relief efforts suggest the need for aid agents to maintain a reflexive awareness of the potential for an influx of outside assistance to disempower those most affected. We argue that barriers to implementing the localization of humanitarian aid can be better understood by po…
Determinants of dynamic inspiratory muscle strength in healthy trained elderly.
2021
Background: The S-Index assessed by means of electronic devices is a measure of Inspiratory Muscle Strength (IMS) that highly correlates with the maximal inspiratory pressure (MIP). The variables involved when using regression models for the prediction of IMS/MIP depend on both the sample characteristics and the device or protocol used. In light of the scarce information on the influence of physical activity (PA) on IMS in healthy older adults (OA), together with the incorporation of new assessment devices, the objectives of this research are: 1) to determine which factors influence the IMS in a group of trained OA, using a portable electronic device; and 2) to propose a regression model to…
Sviluppo di smart Drug Delivery Systems a base polimerica per la terapia inalatoria dell’asma
2021
High-Speed Video Microscopy for Primary Ciliary Dyskinesia Diagnosis: A Study of Ciliary Motility Variations with Time and Temperature
2021
Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/2075-4418/11/7/1301 Este artículo de investigación pertenece al número especial "Progress in Diagnosing and Managing Primary Ciliary Dyskinesia". Primary ciliary dyskinesia (PCD) is a rare disease resulting from a defect in ciliary function that generates, among other issues, chronic upper and lower respiratory tract infections. European guidelines recommend studying ciliary function (pattern (CBP) and frequency (CBF)), together with characteristic clinical symptoms, as one of the definitive tests. However, there is no “gold standard”. The present study aims to use high-speed video microscopy to describe how CBF…
Exploring the application of blockchain to humanitarian supply chains: insights from Humanitarian Supply Blockchain pilot project
2021
PurposeSome studies and reports have recently suggested using blockchain technology to improve transparency and trust in humanitarian supply chains (HSCs). However, evidence-based studies to display the utility and applicability of blockchains in HSCs are missing in the literature. This paper aims to investigate the key drivers and barriers of blockchain application to HSCs and explore whether evidence could support that the application of blockchain improves transparency and trust in HSCs.Design/methodology/approachThis paper puts forward a two-stage approach to explore the blockchain application in HSCs: an initial exploration of humanitarian practitioners and academicians interested in b…
Laughing with machines : philosophical analysis on the preconditions of sense of humour for machines
2021
This article will analyse the preconditions of sense of humour for artificial intelligence. Can artificial intelligence have a sense of humour? Is there a difference between human and machine laughter? Some machines already fulfil certain conditions which are associated with the human sense of humour: on the most superficial level machines appear to laugh and produce jokes, and they recognize sarcasm and punchlines, and they can evaluate funniness. In short, artificial intelligence is already able to recognize humour, and reacts to it accordingly. Furthermore, people laugh with humorous machines. However, it is still uncertain whether artificial intelligence can have a sense of humour or no…
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2021
BACKGROUND Studies investigating a potential association between hypothyroidism and non-alcoholic fatty liver disease (NAFLD) showed conflicting results and large-scale population-based data from Germany on this topic are currently missing. OBJECTIVE It was the aim of this analysis to investigate the impact of thyroid gland disorders on the prevalence of NAFLD in Germany. METHODS In this case-control study, using the German disease Analyzer database (IQVIA), NAFLD patients were matched to patients without NAFLD by age, sex, index year, treating physician, diabetes mellitus type II, and obesity. The main outcome of the study was an association between thyroid gland disorders (hypothyroidism,…
Editorial: Thymic Epithelial Cells: New Insights Into the Essential Driving Force of T-Cell Differentiation.
2021
Antigen carbohydrate 125 as a biomarker in heart failure: a narrative review.
2021
Congestion explains many of the signs and symptoms of acute heart failure (AHF) and disease progression. However, accurate quantification of congestion is challenging in daily practice. Antigen carbohydrate 125 (CA125) or mucin 16 (MUC16), a large glycoprotein synthesized by mesothelial cells, has emerged as a reliable proxy of congestion and inflammation in patients with heart failure. In AHF syndromes, CA125 is strongly associated with right-sided heart failure parameters and a higher risk of adverse clinical events beyond standard prognostic factors, including natriuretic peptides. Furthermore, CA125 has the potential for both monitoring and guide HF treatment following a decompensated H…
I vescovati nella Sicilia normanno-sveva (XI-XIII secolo). Potestà normative e competenze giurisdizionali in un territorio multiculturale
2021
La tesi ha ad oggetto i vescovati di Sicilia nell’età normanna. La ricerca è condotta – oltre che con l’ausilio degli importantissimi risultati storiografici frutto degli studi ormai acquisiti al patrimonio conoscitivo – a partire da una rilettura delle fonti documentarie conservatesi, costituite essenzialmente da atti della Cancelleria comitale e regia, nonché da atti di matrice privatistica, la maggior parte dei quali provenienti dagli Archivi Diocesani. All’indagine su tale tipologia di fonti si accompagna, parallelamente, un’analisi dei dati offerti dalle fonti cronachistiche, utili alla ricostruzione di uno spaccato storico dell’età considerata quanto più completo e affidabile. Il quad…
Demand response e flessibilità energetica degli edifici residenziali
2021
The diamod tip.
2021
This issue 5 is devoted to spine diseases that can be treated or improved by using medical ozone. Dr. Alberto Alexandre compiled during 2015 and 2016 a number of papers from experienced authors in order to prepare a monographic issue but found a lot of difficulty in publishing it. I offered him our Journal to publish these scientific works and he agreed. 
 
 COVID-19 pandemic has produce a huge increase in publishing time for all journals but we finally have been able to produce this issue. Due to the delay in its publication, some papers have been published by their authors in other journals. 
 
 We are hardly working in issue 6 that will be opened for different topics …
Use of Different Food Classification Systems to Assess the Association between Ultra-Processed Food Consumption and Cardiometabolic Health in an Elde…
2021
The PREDIMED-Plus trial was supported by the European Research Council (Advanced Research grant 2014–2019; agreement #340918; granted to M.Á.M.-G.); the official Spanish institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) and Instituto de Salud Carlos III (ISCIII) through the Fondo de Investigación para la Salud (FIS) which is co-funded by the European Regional Development Fund (coordinated FIS projects led by J.S-S. and J.V., including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI…
Antileishmanial Activity of the Genus Piper: A Systematic Review
2021
Background: Leishmaniases are anthropozoonotic vector-borne diseases, caused by the protozoan Leishmania spp. These diseases have significant morbidity and mortality worldwide and, as there are currently no vaccines available for their treatment, chemotherapy remains the mainstay for anti-leishmanial therapeutics. However, the severe side effects, reduced bioavailability, high cost and chemoresistance, amongst other problems, limit the use of available drugs. In recent years, natural compounds have shown promise as anti-leishmanial agents, especially those extracted from medicinal plants. The genus Piper has been used in traditional medicine and widely explored for its biological properties…