showing 36 of ~574560 from 574555 documents
Le strategie di scuse, uno studio pragmatico cross-culturale fra l’arabo libico e l’italiano
2021
La mia ricerca si colloca nell’ambito della pragmatica contrastiva, un campo di ricerca il cui obiettivo è quello di mettere a confronto due lingue differenti in relazione alle strutture e alle forme che due lingue diverse usano nel medesimo contesto d’uso; le differenze fra queste realizzazioni linguistiche sono spiegate attraverso differenze di tipo culturale. I partecipanti allo studio rappresentano due gruppi di parlanti: nativi italiani e nativi arabi. La raccolta dei dati è stata effettuata mediante la compilazione di un sondaggio scritto di tipo DCT (Discourse Completion Test). In concreto, sono state elaborate 10 situazioni comunicative atte a generare nel parlante la sollecitazione…
Demand response e flessibilità energetica degli edifici residenziali
2021
Hydrothermal alteration can result in pore pressurization and volcano instability
2021
AbstractThe collapse of a volcanic flank can be destructive and deadly. Hydrothermal alteration is common to volcanoes worldwide and is thought to promote volcano instability by decreasing rock strength. However, some laboratory studies have shown that not all alteration reduces rock strength. Our new laboratory data for altered rhyodacites from Chaos Crags (Lassen volcanic center, California, USA) show that pore- and crack-filling mineral precipitation can reduce porosity and permeability and increase strength, Young's modulus, and cohesion. A significant reduction in permeability, by as much as four orders of magnitude, will inhibit fluid circulation and create zones of high pore fluid pr…
Proton Pump Inhibitors in Patients With Liver Cirrhosis: Evidence to Improve Their Battered Reputation.
2021
A skeletal Class III malocclusion with agenesis and canine-bicuspid transposition: a nonsurgical approach
2021
Abstract Background The present case report describes the orthodontic management of a patient who presented with a skeletal Class III malocclusion combined with other dental anomalies. The malocclusion was complicated by agenic maxillary lateral incisors and a lower right second premolar, in company with the transposition of the maxillary canines and premolars. Methods Dentoalveolar compensation of the anteroposterior jaw relationship was performed. The upper deciduous lateral incisors were extracted and the spaces closed, so that the first premolars replaced the missing lateral incisors while the canine transposition was maintained Results Satisfactory results were obtained which provided …
Best practices and recommendations for drug regimens and plasma exchange for immune thrombotic thrombocytopenic purpura.
2021
Introduction Thrombotic thrombocytopenic purpura (TTP) is a life-threatening thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, thrombocytopenia, and organ injury. TTP pathophysiology is based on a severe ADAMTS13 deficiency, and is a medical emergency with fatal outcome if appropriate treatment is not initiated promptly. Areas covered Authors will review the best options currently available to minimize mortality, prevent relapses, and obtain the best clinical response in patients with immune TTP (iTTP). Available bibliography about iTTP treatment has been searched in Library's MEDLINE/PubMed database from January 1990 until April 2021. Expert opinion The general…
Sviluppo di smart Drug Delivery Systems a base polimerica per la terapia inalatoria dell’asma
2021
Does periodization work? Athletes perform better in major events than in minor competitions
2021
Previous studies on periodization have led to the view that most athletes fail to peak at major events. These conclusions might be based on definitions of “peak performance” that are too narrow. In this study, a track and field athlete was defined as succeeding in a competition if their outcome was within the acceptable range from the best result of the season. The data are from seven championship finals and semifinals together with 42 Diamond League competitions from the 2010s, altogether 7,087 individual results. All field events and running events up to 400 m were included. The majority of athletes succeeded in major events (67.0% in sprint and 57.5% in field events). Overall, champions…
Northern Hemisphere atmospheric pattern enhancing Eastern Mediterranean Transient-type events during the past 1000 years
2021
High-resolution climate model simulations for the last millennium were used to elucidate the main winter Northern Hemisphere atmospheric pattern during enhanced Eastern Mediterranean Transient (EMT-type) events, a situation in which an additional overturning cell is detected in the Mediterranean at the Aegean Sea. The differential upward heat flux between the Aegean Basin and the Gulf of Lion was taken as a proxy of EMT-type events and correlated with winter mean geopotential height at 500 mbar in the Northern Hemisphere (20–90∘ N and 100∘ W–80∘ E). Correlations revealed a pattern similar to the East Atlantic/Western Russian (EA/WR) mode as the main driver of EMT-type events, with the past …
Associations of Classroom Design and Classroom-Based Physical Activity with Behavioral and Emotional Engagement among Primary School Students
2021
Educational reforms worldwide have resulted in schools increasingly incorporating open and flexible classroom designs. Open learning spaces may contribute to a student’s behavioral and emotional school engagement directly and by facilitating classroom-based physical activity (CPA). We investigated the associations between accelerometer-assessed CPA and student ratings of task-focused behavior and attitude towards school as indicators for behavioral and emotional engagement, respectively, with the associations of gender, grade, and classroom design on CPA among 206 3rd and 5th grade students in open learning spaces and conventional classrooms. Structural equation modelling showed open classr…
Antileishmanial Activity of the Genus Piper: A Systematic Review
2021
Background: Leishmaniases are anthropozoonotic vector-borne diseases, caused by the protozoan Leishmania spp. These diseases have significant morbidity and mortality worldwide and, as there are currently no vaccines available for their treatment, chemotherapy remains the mainstay for anti-leishmanial therapeutics. However, the severe side effects, reduced bioavailability, high cost and chemoresistance, amongst other problems, limit the use of available drugs. In recent years, natural compounds have shown promise as anti-leishmanial agents, especially those extracted from medicinal plants. The genus Piper has been used in traditional medicine and widely explored for its biological properties…
Zvaigžņu aicinājums: Latvijas Universitātes astronomijas studentu (1920-1949) dzīvesstāsti
2021
Grāmatā ievietota 51 Latvijas Universitātes astronomijas studenta (1920 – 1949) īsa biogrāfija. Divdesmit kādreizējie astronomijas studenti kļuva par profesionāliem astronomiem, matemātiķiem vai fiziķiem tepat Latvijā vai trimdā, daļa kļuva par pazīstamiem pedagogiem. Par pārējiem astronomijas studentiem, kopskaitā 31, grāmatā vienkop un izvērsti stāstīts pirmo reizi. Biogrāfijas papildina vizuālais materiāls, kas vēsta par Latvijas Universitātes Astronomiskās observatorijas vēsturi 20. gs. 20. un 30. gados.
Plant hunting: exploring the behaviour of amateur botanists in the field
2021
We asked what are the behavioural and logistic preferences of professional and amateur botanists when exploring flora in the field. We extracted temporal and spatial data on vas- cular plant species occurrences from three datasets of Sicilian flora: a subset of iNaturalist, a dataset collected by a Facebook group focused on the flora of Sicily and a subset of the professional database European Vegetation Archive. We used the time span of individual contributor’s activity as a proxy of their commitment to collecting information about the flora of Sicily. Climate and landscape data were used to better characterize the spatial and temporal activity of data contributors. Finally, we assessed wh…
The gap between knowledge and belief: narrative, affect and students’ deeper learning in higher education
2021
One of the central challenges educators face today, especially in higher education, is the gap between warranted (domain-specific) knowledge and the prior beliefs students hold about certain concep...
Diffusional Kurtosis Imaging in the Diffusion Imaging in Python Project
2021
ABSTRACTDiffusion-weighted magnetic resonance imaging (dMRI) measurements and models provide information about brain connectivity and are sensitive to the physical properties of tissue microstructure. Diffusional Kurtosis Imaging (DKI) quantifies the degree of non-Gaussian diffusion in biological tissue from dMRI. These estimates are of interest because they were shown to be more sensitive to microstructural alterations in health and diseases than measures based on the total anisotropy of diffusion which are highly confounded by tissue dispersion and fiber crossings. In this work, we implemented DKI in the Diffusion in Python (DIPY) project - a large collaborative open-source project which …
Development of a low-cost portable PAR device for crop management
2021
Context: It becomes essential to have precise monitoring of crop growth to ensure rapid action in case of problems. Plant growth depends on the biomass accumulated by photosynthesis that requires as an energy source, the photosynthetically active radiation (PAR). This local variable is essential to study the plant phenology and for ecophysiological models that predict the accumulation of dry matter on a daily basis. Objectives: We design and evaluate a low-cost portable device, PAR Acquisition Device (PARADe), combining a PAR radiation sensor and a microcontroller acquisition card (Arduino) in order to measure automatically the in-field photosynthetically active radiation.
Keir Starmer’s Astronomical Revolution : going forward by going back
2021
International audience
Multicatalytic Transformation of (Meth)acrylic Acids: a One-Pot Approach to Biobased Poly(meth)acrylates
2021
International audience; Shifting from petrochemical feedstocks to renewable resources can address some of the environmental issues associated with petrochemical extraction and make plastics production sustainable. Therefore, there is a growing interest in selective methods for transforming abundant renewable feedstocks into monomers suitable for polymer production. Reported herein are one-pot catalytic systems, that are active,<br>productive, and selective under mild conditions for the synthesis of copolymers from renewable materials. Each system allows for anhydride formation, alcohol acylation and/or acid esterification, as well as polymerization of the formed (meth)- acrylates, providi…
Independent Validation of Sepsis Index for Sepsis Screening in the Emergency Department
2021
(1) Background: The early detection of sepsis is still challenging, and there is an urgent need for biomarkers that could identify patients at a high risk of developing it. We recently developed an index, namely the Sepsis Index (SI), based on the combination of two CBC parameters: monocyte distribution width (MDW) and mean monocyte volume (MMV). In this study, we sought to independently validate the performance of SI as a tool for the early detection of patients at a high risk of sepsis in the Emergency Department (ED). (2) Methods: We enrolled all consecutive patients attending the ED with a request of the CBC. MDW and MMV were measured on samples collected in K3-EDTA tubes on the UniCel …
Analysis of different key behavioral patterns to score in elite taekwondoists according to the weight category and gender
2021
Traditionally, research in taekwondo has focused on athletes' overall performance considering the entire sample of the tournament or analyzed selected bouts while ignoring behavioral differences of athletes according to their gender and weight category. Thus, the aim of this study was to analyze the behavioral patterns used to score points in the London Olympic Games according to gender and weight category [fin (FW), feather (FTW), light (LW), and heavy (HW)] of the athletes. A total of 24,940 actions were analyzed by using observational methodology, a mixed method methodology where lag sequential and polar coordinate analysis were applied. Different patterns could be seen in the actions pe…
THE ANTINEOPLASTIC ROLE OF STAT5 INHIBITION IN BCRABL1-POSITIVE CELLS EXPOSED TO PIMOZIDE ALONE AND IN COMBINATION WITH DASATINIB AND PONATINIB
2021
EVEN though the last decades have seen the success of the targeted treatments for BCRABL1-positive Chronic Myeloid Leukemia (CML), with the outstanding achievement of placing selected patients into the so called treatment-free remission, a minor part of these subjects face TKI resistance and/or intolerance. Resistance is a challenging point in the clinical management of CML, occurring in approximately 10–20% of CML cases, due to several mechanisms, among which point mutations of the BCR‐ABL kinase domain, BCRABL overexpression or alternative splicing, sub-efficient plasma concentration of the inhibitor and abnormal drug efflux/influx. The Signal Transducer and Activators of Transcription (S…
Web Usage Mining by Neural Hybrid Prediction with Markov Chain Components
2021
This paper presents and evaluates a two-level web usage prediction technique, consisting of a neural network in the first level and contextual component predictors in the second level. We used Markov chains of different orders as contextual predictors to anticipate the next web access based on specific web access history. The role of the neural network is to decide, based on previous behaviour, whose predictor’s output to use. The predicted web resources are then prefetched into the cache of the browser. In this way, we considerably increase the hit rate of the web browser, which shortens the load times. We have determined the optimal configuration of the proposed hybrid predictor on a real…
Therapeutic metaphors and personal meanings in group poetry therapy for people with schizophrenia
2021
This article concerns the therapeutic potential of metaphor in group poetry therapy, concentrating on the poetry therapy process of people diagnosed with schizophrenia. The data was collected in a one-year poetry therapy group. The main questions were: (1) What kind of therapeutic potential can metaphors offer in group poetry therapy? (2) What are the personal meanings and evaluations that the participants give to the therapy process and its effects on their lives? (3) What are the most significant elements in poetry therapy from the viewpoint of the client? The analysis was based on the Grounded theory method. The results showed that the most significant therapeutic factors of the process …
Lifetime predictions of non-ionic and ionic biopolymers: kinetic studies by non-isothermal thermogravimetric analysis
2021
AbstractIn this paper, films based on sustainable polymers with variable charge have been investigated by non-isothermal thermogravimetry in order to predict their lifetime, which is a key parameter for their potential use in numerous technological and biomedical applications. Specifically, chitosan has been selected as positively charged biopolymer, while alginate has been chosen as negatively charged biopolymer. Among non-ionic polymers, methylcellulose has been investigated. Thermogravimetric measurements at variable heating rates (5, 10, 15 and 20 °C min−1) have been performed for all the polymers to study their degradation kinetics by using isoconversional procedures combined with ‘Mas…
Electrochemical Oxidative C – C Bond Formation
2021
Microbiota Gut–Brain Axis in Ischemic Stroke: A Narrative Review with a Focus about the Relationship with Inflammatory Bowel Disease
2021
The gut microbiota is emerging as an important player in neurodevelopment and aging as well as in brain diseases including stroke, Alzheimer’s disease, and Parkinson’s disease. The complex interplay between gut microbiota and the brain, and vice versa, has recently become not only the focus of neuroscience, but also the starting point for research regarding many diseases such as inflammatory bowel diseases (IBD). The bi-directional interaction between gut microbiota and the brain is not completely understood. The aim of this review is to sum up the evidencesconcerningthe role of the gut–brain microbiota axis in ischemic stroke and to highlight the more recent evidences about the potential r…
The Dynamics of Perspective in Quantum Physics: An Analysis in the Context of Teacher Education
2021
Debates on the philosophical interpretations of quantum physics have motivated a renewed interest in how secondary and lower undergraduate students interpret quantum phenomena. In an attempt to contribute to this effort, this paper examines the dynamics of perspec tive in quantum physics in the context of teacher education. The goal of the study is to investigate how students (N = 36) from a Master's Degree in Secondary Education Teacher Training in Spain negotiate perspective as they participate in small-group discussions of quantum physics topics. This study focuses on the wave-particle duality, superposition of states, and the calculation of probabilities for two-state systems. The metho…
Pseudorapidity distributions of charged particles as a function of mid- and forward rapidity multiplicities in pp collisions at √s = 5.02, 7 and 13 T…
2021
The multiplicity dependence of the pseudorapidity density of charged particles in proton–proton (pp) collisions at centre-of-mass energies √s = 5.02, 7 and 13 TeV measured by ALICE is reported. The analysis relies on track segments measured in the midrapidity range (|η|<1.5). Results are presented for inelastic events having at least one charged particle produced in the pseudorapidity interval |η|<1. The multiplicity dependence of the pseudorapidity density of charged particles is measured with mid- and forward rapidity multiplicity estimators, the latter being less affected by autocorrelations. A detailed comparison with predictions from the PYTHIA 8 and EPOS LHC event generators is also p…
Modification of Angular Kinematics and Spatiotemporal Parameters during Running after Central and Peripheral Fatigue
2021
Fatigue causes kinematics modifications during running, and it could be related to injuries. The aim was to identify and compare the effects of central and peripheral fatigue on angular kinematics and spatiotemporal parameters during running. Angular kinematics and spatiotemporal parameters were evaluated using an infrared motion capture system and were registered during 2 min treadmill running in pre- and post-fatigue states in eighteen male recreational runners. Central fatigue was induced by a 30 min running fatigue protocol on a treadmill, while peripheral fatigue in quadriceps and hamstrings muscles was induced by an isokinetic dynamometer fatigue protocol. Central fatigue increased th…
Elementary Integration of Superelliptic Integrals
2021
Consider a superelliptic integral $I=\int P/(Q S^{1/k}) dx$ with $\mathbb{K}=\mathbb{Q}(\xi)$, $\xi$ a primitive $k$th root of unity, $P,Q,S\in\mathbb{K}[x]$ and $S$ has simple roots and degree coprime with $k$. Note $d$ the maximum of the degree of $P,Q,S$, $h$ the logarithmic height of the coefficients and $g$ the genus of $y^k-S(x)$. We present an algorithm which solves the elementary integration problem of $I$ generically in $O((kd)^{\omega+2g+1} h^{g+1})$ operations.
What do we know about growth of vessel elements of secondary xylem in woody plants?
2021
Despite extensive knowledge about vessel element growth and the determination of the axial course of vessels, these processes are still not fully understood. They are usually explained as resulting primarily from hormonal regulation in stems. This review focuses on an increasingly discussed aspect - mechanical conditions in the vascular cambium. Mechanical conditions in cambial tissue are important for the growth of vessel elements, as well as other cambial derivatives. In relation to the type of stress acting on cambial cells (compressive versus tensile stress) we: (i) discuss the shape of the enlarging vessel elements observed in anatomical sections; (ii) present hypotheses regarding the …
Spin Crossover in a Series of Non-Hofmann-Type Fe(II) Coordination Polymers Based on [Hg(SeCN)3]− or [Hg(SeCN)4]2– Building Blocks
2021
Self-assembly of [Hg(SeCN)4]2- tetrahedral building blocks, iron(II) ions, and a series of bis-monodentate pyridyl-type bridging ligands has afforded the new heterobimetallic HgII-FeII coordination polymers {Fe[Hg(SeCN)3]2(4,4'-bipy)2}n (1), {Fe[Hg(SeCN)4](tvp)}n (2), {Fe[Hg(SeCN)3]2(4,4'-azpy)2}n (3), {Fe[Hg(SeCN)4](4,4'-azpy)(MeOH)}n (4), {Fe[Hg(SeCN)4](3,3'-bipy)}n (5) and {Fe[Hg(SeCN)4](3,3'-azpy)}n (6) (4,4-bipy = 4,4'-bipyridine, tvp = trans-1,2-bis(4-pyridyl)ethylene, 4,4'-azpy = 4,4'-azobispyridine, 3,3-bipy = 3,3'-bipyridine, 3,3'-azpy = 3,3'-azobispyridine). Single-crystal X-ray analyses show that compounds 1 and 3 display a two-dimensional robust sheet structure made up of infini…
Exploring relationships between drought and epidemic cholera in Africa using generalised linear models
2021
AbstractBackgroundTemperature and precipitation are known to affect Vibrio cholerae outbreaks. Despite this, the impact of drought on outbreaks has been largely understudied. Africa is both drought and cholera prone and more research is needed in Africa to understand cholera dynamics in relation to drought.MethodsHere, we analyse a range of environmental and socioeconomic covariates and fit generalised linear models to publicly available national data, to test for associations with several indices of drought and make cholera outbreak projections to 2070 under three scenarios of global change, reflecting varying trajectories of CO2 emissions, socio-economic development, and population growth…
Macrophages govern antiviral responses in human lung tissues protected from SARS-CoV-2 infection
2021
SUMMARYThe majority of SARS-CoV-2 infections among healthy individuals result in asymptomatic to mild disease. However, the immunological mechanisms defining effective lung tissue protection from SARS-CoV-2 infection remain elusive. Unlike mice solely engrafted with human fetal lung xenograft (fLX), mice co-engrafted with fLX and a myeloid-enhanced human immune system (HNFL mice) are protected against SARS-CoV-2 infection, severe inflammation, and histopathology. Effective control of viral infection in HNFL mice associated with significant macrophage infiltration, and the induction of a potent macrophage-mediated interferon response. The pronounced upregulation of the USP18-ISG15 axis (a ne…
Typification of seven names in the genus Antirrhinum (tribe Antirrhineae, Plantaginaceae)
2021
The typification of seven names in the genus Antirrhinum (tribe Antirrhineae, Plantaginaceae): A. charidemi, A. latifolium, A. molle var. mollissimum, A. molle var. marianum, A. sempervirens, A. siculum, and A. valentinum is discussed. The designation of the nomenclatural types is based on the consultation of original material and the literature cited in the respective protologues. The names are lectotypified using specimens from BC, C, MA, and an illustration of Boccone published in 1697. An epitype is also designated for A. latifolium due to ambiguity in the interpretation of the lectotype. The name A. siculum is neotypified from a specimen preserved at VAL, and a second-step lectotypific…