showing 36 of ~574560 from 574555 documents
Solvatochromic behaviour of new donor–acceptor oligothiophenes
2021
Oligothiophene derivatives play a central role in the formulation of materials used in devices in the field of organic electronics. In this work, we report the results of the study of UV-vis absorption and fluorescence spectra, in several solvents, of a series of oligothiophenes recently synthesized in our laboratory. The studied oligothiophenes present different structures due to several factors: the donor– acceptor (D–A) or acceptor–donor–acceptor (A–D–A) architecture, the number of thiophene rings in the backbone (ranging from three to eight), the number and position of solubilizing octyl chains in the backbone, and the type of acceptor moieties (from Knoevenagel condensation either with…
Fibroblast activation protein inhibitor (FAPi) positive tumour fraction on PET/CT correlates with Ki-67 in liver metastases of neuroendocrine tumours
2021
Abstract Aim Gallium-68-labelled inhibitors of the fibroblast activation protein (FAPi) enable positron emission tomography/computed tomography (PET/CT) imaging of fibroblast activation. We evaluated if [68Ga]Ga-DATA5m.SA.FAPi PET/CT is related to Ki-67 as a marker of tumour aggressiveness in patients with liver metastases of NET. Methods Thirteen patients with liver metastases of a histologically confirmed NET who underwent PET/CT with [68Ga]Ga-DATA5m.SA.FAPi, [18F]FDG and [68Ga]Ga-DOTA-TOC were retrospectively analyzed. PET-positive liver tumour volumes were segmented for calculation of volume, SUVmax and PET-positive tumour fraction (TF). PET parameters were correlated with Ki-67. Result…
Un « situationnisme » belge ? Sur le passage de Pouvoir ouvrier belge à travers une assez courte unité de temps
2021
International audience
Four great magnalia of government. La riforma istituzionale di Henry Neville: un machiavelliano inglese alla corte di Cosimo III de’ Medici
2021
The tumultuous phase running from the beheading of Charles I to the Glorious Revolution is the time frame in which England goes through the crucial phases that will put an end to royal absolutism. One of the most authoritative intellectual figures of that founding historical moment of modern constitutionalism is Henry Neville, author of political and satirical pamphlets who, taking up the lesson of the ancients with the experience of “modern things”, published in 1680 the Plato Redivivus, a work that will consecrate him as a Republican political thinker. The treaty, written and published in the context of the Exclusion crisis, exhort Charles II to reduce his powers. The disease suffered by…
Syndiqué, sois un syndicaliste ! La brochure comme outil de formation syndicale pour la CGT des années 1930
2021
International audience
Pharmacokinetics of Direct Oral Anticoagulants in Emergency Situations: Results of the Prospective Observational RADOA-Registry
2021
Thrombosis and haemostasis 122(4), 552-559 (2022). doi:10.1055/a-1549-6556
Optimization of a GF-AAS method for lead testing in blood and urine: A useful tool in acute abdominal pain management in emergency.
2021
Suspicion of lead poisoning is confirmed by its concentration in blood and protoporphyrin red blood cells. At low concentrations, lead influences the synthesis of the heme in the sense of lowering it. Acute and chronic lead intoxication is extremely polymorphic in regards to its clinical manifestations, with digestive, hematological, cardiovascular, renal hepatic and neurological features. The aim of the study was to evaluate the presence of lead in human whole blood and urine harvested before and during chelation treatment in the case of lead poisoning. An atomic absorption spectroscopic method for the analysis of lead was developed using graphite furnace atomic absorption spectrophotomete…
Utilización de Kahoot! en las clases teóricas de Anatomía Patológica: mejorando la motivación e interacción en la docencia virtual
2021
[EN] Faced with the COVID-19 pandemic situation, education has had to adapt to online teaching, trying to preserve the essential student-teacher interaction. In this project we used the interactive tool Kahoot! in the theory lectures of Special Anatomical Pathology of the Degree in Medicine, which were fully taught online. The games consisted of questions about the lesson´s contents, to strengthen learning and self-evaluation. After playing Kahoot!, results were discussed to highlight important concepts and explain doubts. The perception of the students was evaluated through an online survey. The results indicate that using Kahoot! in the theory classes has been very satisfactory and has en…
Küpalme (la descendencia) como saber educativo intercultural desde la mirada de los Kimche (sabios) del pueblo Mapuche
2021
El pensarse vinculado con otros o como parte de un ser juntos implica procesos y prácticas cotidianas de construcción de vínculos que se conectan con procesos de memoria en contextos políticos más amplios (Carsten, 2007). En este contexto, nos propusimos analizar los significados que las familias mapuches otorgaban al küpalme en la educación de niños y niñas. Optamos por una metodología cualitativa a través de entrevistas a kimche y xemkeche de comunidades indígenas de la IX región de la Araucanía, Chile. Los discursos muestran como el Küpalme está asociado a la herencia social, cultural y espiritual del ser mapuche y como ciertos elementos culturales, territoriales, sanguíneos y vivenciale…
Soiden ennallistamisen suoluonto-, vesistö- ja ilmastovaikutukset. Luontopaneelin yhteenveto ja suositukset luontopolitiikan suunnittelun ja päätökse…
2021
Suomen alkuperäisestä 10,4 miljoonan hehtaarin suoalasta yli puolet on ojitettu metsä- ja maatalouden sekä turvetuotannon tarpeisiin. Etelä-Suomessa ojitus on ollut voimakkainta: keskimäärin noin 75 prosenttia ja monin paikoin vielä suurempi osa soista on ojitettu. Suot ovat Euroopan luontotyypeistä kaikkein uhanalaisin luontotyyppiryhmä ja Suomella on erityisvastuu soiden suojelusta. Kaikkiaan 54 prosenttia Suomen 50 suoluontotyypistä on uhanalaisia ja lisäksi 20 prosenttia on silmällä-pidettäviä. Ensisijaisesti Suomen soilla elävistä lajeista 11 prosenttia eli yhteensä 120 lajia on uhanalaisia. Uhanalaisilla lajeilla ja luontotyypeillä on korkea riski hävitä Suomesta. Mittava ojitus näkyy…
Conceptualizing nature-based science tourism: a case study of Seili Island, Finland
2021
Nature-based tourism has been widely addressed, yet research on nature-based science tourism, founded on science, scientific knowledge, and/or engagement in scientific research, is still scarce. Drawing on tourist motivation, nature-based tourism, special interest tourism, and science tourism, a novel theoretical conceptualization of nature-based science tourism was developed. The framework identified three categories of science tourism with intensifying levels of tourists’ interest in scientific knowledge and tourist engagement: tourism based on scientific knowledge, tourism with scientific adventure or volunteering, and scientific research tourism. In the empirical part, the framework was…
Poszukiwanie pełni. David Jones i fragmenty pisma
2021
Gutorow podjął próbę opisania i scharakteryzowania twórczości Davida Jonesa, brytyjskiego poety, malarza i eseisty kojarzonego ze zwrotem modernistycznym pierwszej połowy XX wieku. Podobnie jak inni moderniści, Jones postawił w punkcie wyjścia ponurą diagnozę nowoczesności – żyjemy w epoce wyczerpania się dotychczasowych narracji, w epoce duchowego, a więc i egzystencjalnego kryzysu, w czasie należącym do „ostatniego człowieka” (Nietzscheański Letzter Mensch), w świecie, który uległ rozpadowi i musi zostać złożony na nowo. Momenty te wyraźne są w dwóch najważniejszych i najdłuższych utworach poetyckich Jonesa: In Parenthesis (1937) i The Anathemata (1952), obszernych poematach, których frag…
Catalytic Dehydration of Fructose to 5-Hydroxymethylfurfural in Aqueous Medium over Nb2O5-Based Catalysts
2021
The catalytic dehydration of fructose to 5-hydroxymethylfurfural (HMF) in water was performed in the presence of pristine Nb2O5 and composites containing Nb and Ti, Ce or Zr oxides. In all experiments, fructose was converted to HMF using water as the solvent. The catalysts were characterized by powder X-ray diffraction, scanning electron microscopy, N2 physical adsorption, infrared and Raman spectroscopy and temperature-programmed desorption of NH3. Experimental parameters such as fructose initial concentration, volume of the reacting suspension, operation temperature, reaction time and amount of catalyst were tuned in order to optimize the catalytic reaction process. The highest selectivit…
L’inscription des formes brèves dans les processus de médiations documentaires sur le Web et les médias sociaux
2021
International audience
The Impact of Artificial Intelligence on Traditional Chinese Medicine
2021
Traditional Chinese Medicine (TCM) is a well-established medical system with a long history. Currently, artificial intelligence (AI) is rapidly expanding in many fields including TCM. AI will significantly improve the reliability and accuracy of diagnostics, thus increasing the use of effective therapeutic methods for patients. This systematic review provides an updated overview on the major breakthroughs in the field of AI-assisted TCM four diagnostic methods, syndrome differentiation, and treatment. AI-assisted TCM diagnosis is mainly based on digital data collected by modern electronic instruments, which makes TCM diagnosis more quantitative, objective, and standardized. As a result, th…
Brima: Low-Overhead Browser-Only Image Annotation Tool (Preprint)
2021
Image annotation and large annotated datasets are crucial parts within the Computer Vision and Artificial Intelligence this http URL the same time, it is well-known and acknowledged by the research community that the image annotation process is challenging, time-consuming and hard to scale. Therefore, the researchers and practitioners are always seeking ways to perform the annotations easier, faster, and at higher quality. Even though several widely used tools exist and the tools' landscape evolved considerably, most of the tools still require intricate technical setups and high levels of technical savviness from its operators and crowdsource contributors. In order to address such challenge…
Characteristics of neonatal herpes simplex virus infections in Germany: results of a 2-year prospective nationwide surveillance study.
2021
ObjectiveTo assess incidence and burden of neonatal herpes simplex virus (HSV) infections and to explore possible transmission routes.MethodsA 2-year prospective nationwide surveillance study performed in 2017 and 2018. All German paediatric departments (n=464 in 2017, n=441 in 2018) were contacted on a monthly basis to report potential cases of neonatal HSV infections. Infants with a postnatal age of ≤60 days and a positive HSV PCR or HSV culture from skin, mucous membrane, vesicles or conjunctival smear, blood or cerebrospinal fluid were included in the study.Results37 cases were analysed. 29 patients who exhibited no or only mild clinical symptoms were discharged home without organ damag…
false
2021
The coronavirus pandemic has affected more than 150 million people, while over 3.25 million people have died from the coronavirus disease 2019 (COVID-19). As there are no established therapies for COVID-19 treatment, drugs that inhibit viral replication are a promising target; specifically, the main protease (Mpro) that process CoV-encoded polyproteins serves as an Achilles heel for assembly of replication-transcription machinery as well as down-stream viral replication. In the search for potential antiviral drugs that target Mpro, a series of cembranoid diterpenes from the biologically active soft-coral genus Sarcophyton have been examined as SARS-CoV-2 Mpro inhibitors. Over 360 metabolite…
Wi-Sense: a passive human activity recognition system using Wi-Fi and convolutional neural network and its integration in health information systems
2021
AbstractA human activity recognition (HAR) system acts as the backbone of many human-centric applications, such as active assisted living and in-home monitoring for elderly and physically impaired people. Although existing Wi-Fi-based human activity recognition methods report good results, their performance is affected by the changes in the ambient environment. In this work, we present Wi-Sense—a human activity recognition system that uses a convolutional neural network (CNN) to recognize human activities based on the environment-independent fingerprints extracted from the Wi-Fi channel state information (CSI). First, Wi-Sense captures the CSI by using a standard Wi-Fi network interface car…
Frontiers in Physiology
2021
Besides its roles in locomotion and thermogenesis, skeletal muscle plays a significant role in global glucose metabolism and insulin sensitivity through complex nutrient sensing networks. Our previous work showed that the muscle-specific ablation of O-GlcNAc transferase (OGT) led to a lean phenotype through enhanced interleukin-15 (IL-15) expression. We also showed OGT epigenetically modified and repressed the Il15 promoter. However, whether there is a causal relationship between OGT ablation-induced IL-15 secretion and the lean phenotype remains unknown. To address this question, we generated muscle specific OGT and interleukin-15 receptor alpha subunit (IL-15rα) double knockout mice (mDKO…
Eloge du texticule
2021
International audience
The association of patient age with postoperative morbidity and mortality following resection of intracranial tumors
2021
Abstract Introduction The postoperative functional status of patients with intracranial tumors is influenced by patient-specific factors, including age. Research question This study aimed to elucidate the association between age and postoperative morbidity or mortality following the resection of brain tumors. Material and methods A multicenter database was retrospectively reviewed. Functional status was assessed before and 3–6 months after tumor resection by the Karnofsky Performance Scale (KPS). Uni- and multivariable linear regression were used to estimate the association of age with postoperative change in KPS. Logistic regression models for a ≥10-point decline in KPS or mortality were b…
Les formes brèves du politique. Introduction
2021
International audience
Measuring Meaning
2021
This study will present a tool designed for meaning extraction with monoclausal sentences in Italian. Its main features will be illustrated with instances of the Italian causative clause type featuring the verb fare ‘make’ (e.g. Egli fa piangere il bambino ‘He makes the child cry’), a construction which invariably embeds a clause (e.g.Il bambino piange ‘The child cries’) with which it establishes an entailment relationship. The tool automatically accomplishes the following tasks: it answers relevantwh- questions (e.g. Who cries? Who makes someone cry?) and detects the entailment. Concurrent with this presentation, this study will also encourage a reflection on the research currently being c…
Voronovskaya type results and operators fixing two functions
2021
The present paper deals with positive linear operators which fix two functions. The transfer of a given sequence (Ln) of positive linear operators to a new sequence (Kn) is investigated. A general procedure to construct sequences of positive linear operators fixing two functions which form an Extended Complete Chebyshev system is described. The Voronovskaya type formula corresponding to the new sequence which is strongly influenced by the nature of the fixed functions is obtained. In the last section our results are compared with other results existing in literature.
Rutting analysis of different rubberised stone mastic asphalt mixtures: from binders to mixtures
2021
Stone Mastic Asphalt (SMA) has been broadly used on heavily trafficked roads and motorways in the UK due to its known stability and durability. In this study, several sets of SMA mixtures were produced using different rubberised bitumens, including a Fischer–Tropsch wax pre-treated rubberised bitumen. Properties associated with rutting were evaluated using both linear and nonlinear viscoelastic analyses, using different test methods such as the Strategic Highway Research Programme (SHRP), Shenoy rutting parameter, zero shear viscosity (ZSV) and multiple stress creep recovery (MSCR) tests. The rutting resistance of the resulting SMA mixtures was assessed using the Repeated Load Axial Test (R…
HIV-related non-Hodgkin lymphomas affecting the oral cavity: a clinicopathologic study of 11 cases
2021
HIV-related non-Hodgkin lymphomas of the oral cavity are rare lesions with aggressive clinical behaviour. The aim of this study is to describe the clinicopathological features of a series of HIV-related oral non-Hodgkin lymphomas. Eleven cases of oral lymphomas affecting HIV-positive patients were retrieved from 2012 to 2019. Clinicopathological features regarding age, sex, tumour location, clinical presentation, laboratory findings, disease stage and follow-up were obtained. Histologic, immunohistochemical and in situ hybridization for EBV detection were done for diagnosis confirmation. Overall survival was estimated by Kaplan?Meier curve. Males predominated, with a mean age of 40.3 years-…
Une Alsace de papier : Hansi, la forme brève illustrée et la promotion d’une identité régionale
2021
International audience
Different Within-Host Viral Evolution Dynamics in Severely Immunosuppressed Cases with Persistent SARS-CoV-2
2021
12 páginas, 2 figuras, 1 tabla.
Telomere Length, SIRT1, and Insulin in Male Master Athletes: The Path to Healthy Longevity?
2021
AbstractLower SIRT1 and insulin resistance are associated with accelerated telomere shortening. This study investigated whether the lifestyle of master athletes can attenuate these age-related changes and thereby slow aging. We compared insulin, SIRT1, and telomere length in highly trained male master athletes (n=52; aged 49.9±7.2 yrs) and age-matched non-athletes (n=19; aged 47.3±8.9 yrs). This is a cross-sectional study, in which all data were collected in one visit. Overnight fasted SIRT1 and insulin levels in whole blood were assessed using commercial kits. Relative telomere length was determined in leukocytes through qPCR analyses. Master athletes had higher SIRT1, lower insulin, and l…
Does the Site of Blood Collection in Fish Affect Haematological and Blood Biochemical Results?
2021
The values of haematological and selected blood plasma biochemical parameters of juvenile common carp (Cyprinus carpio Linnaeus, 1758) were compared between blood samples taken from caudal vein and heart to evaluate the influence of blood sampling body site on the obtained results in two groups of fish of different blood sampling order: I – first by caudal and then by cardiac puncture, II – first by cardiac and then by caudal puncture. The obtained results revealed statistically significant (p<0.05) differences only in group I where red blood cell (RBC) count was higher in caudal vein blood, while haematocrit (Ht) value, mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), …
The Yeast eIF2 Kinase Gcn2 Facilitates H 2 O 2 -Mediated Feedback Inhibition of Both Protein Synthesis and Endoplasmic Reticulum Oxidative Folding du…
2021
Recombinant protein production is a known source of oxidative stress. However, knowledge of which reactive oxygen species are involved or the specific growth phase in which stress occurs remains lacking. Using modern, hypersensitive genetic H2O2-specific probes, microcultivation, and continuous measurements in batch culture, we observed H2O2 accumulation during and following the diauxic shift in engineered Saccharomyces cerevisiae, correlating with peak α-amylase production. In agreement with previous studies supporting a role of the translation initiation factor kinase Gcn2 in the response to H2O2, we find that Gcn2-dependent phosphorylation of eIF2α increases alongside translational atten…
Le surréalisme en papillons : détourner, propager, archiver
2021
International audience; Les papillons produits par le surréalisme à la fin de 1924 constituent un corpus intimement lié à l’organisation même du mouvement et de son Bureau de recherches surréalistes. Mais tout en reprenant le papillon au champ politique, le surréalisme le transforme en objet à la fois poétique, onirique et bibliophilique. Le papillon surréaliste obéit ainsi à une triple démarche : il détourne la communication politique ou commerciale pour en transposer les codes dans le champ de l’avant-garde littéraire et artistique ; il propose et propage une définition, une éthique et une généalogie du surréalisme ; il porte témoignage d’une activité collective qui tend aussitôt à le tra…
Coronavirus Disease (COVID-19) and Its Psychobehavioral Consequences
2021
Cuatro cerámicas con epigrafía árabe del Museu de Borriana
2021
En este trabajo se da a conocer una muestra de las más destacadas cerámicas de época almohade que se conservan en el Museo Arqueológico de Borriana y que proceden de excavaciones arqueológicas realizadas en la ciudad y su entorno. Se presta especial atención a la decoración epigráfica pintada o incisa sobre la arcilla fresca y la estampillada. Del análisis de su decoración epigráfica se ha extraído información de notable interés que complementa aquella directamente derivada del análisis tipológico. This paper will present a sample of the most outstanding Almohad ceramics that are preserved in the Archaeological Museum of Borriana. These pieces have been found during the archaeological excav…
Annoyance due to residential road traffic and aircraft noise: Empirical evidence from two European cities
2021
Based on a study in two European cities, Mainz in Germany and Zurich in Switzerland, the article investigates both acoustical and non-acoustical factors affecting indoor annoyance due to residential road traffic and aircraft noise. We specifically focus on three factors: (1) the role of windows as a feature of the building where people live; (2) the role of individual environmental concern as a general attitude; and (3) the role of household income as an indicator of socioeconomic resources. Empirical results show that closed windows in general and closed high-quality windows in particular are an important barrier against outdoor road traffic and aircraft noise, as well as a helpful subject…