Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma.

2021

Getting around the blood–brain barrier The meninges comprise three membranes that surround and protect the central nervous system (CNS). Recent studies have noted the existence of myeloid cells resident there, but little is known about their ontogeny and function, and whether other meningeal immune cell populations have important roles remains unclear (see the Perspective by Nguyen and Kubes). Cugurra et al. found in mice that a large proportion of continuously replenished myeloid cells in the dura mater are not blood derived, but rather transit from cranial bone marrow through specialized channels. In models of CNS injury and neuroinflammation, the authors demonstrated that these myeloid c…

Motor Competence and Health-related Fitness of School-Age Children: A Two-Year Latent Transition Analysis

2021

PURPOSE The aims of this study were twofold: 1) to identify latent physical performance profiles of motor competence (MC) and cardiorespiratory (CF) and muscular fitness (MF) among school-age children and 2) explore transition probabilities in physical performance profiles over a 2-yr period. METHODS The present sample comprised 1148 (583 girls, 565 boys) elementary school students (baseline Mage = 11.27 ± 0.32), and data were collected annually (equal intervals) over a period of 2 yr which resulted in a total of three measurements. The measures used were the throwing-catching combination test, 5-leaps and two-legged jumps from side-to-side test (MC), 20-meter shuttle run test (CF), and cur…

Mediation of perceived stress and cortisol in the association between neuroticism and global cognition in older adults: A longitudinal study.

2021

Neuroticism has been associated with a greater dementia risk, but its association with cognitive decline in healthy older adults remains unclear. Stress has been proposed as one of the mechanisms that could explain this relationship. Our aim was to analyse, in healthy older people, the mediating role of perceived stress and the Hypothalamic–Pituitary–Adrenal (HPA) axis in the association between neuroticism and global cognition. At Waves 1 and 2 (4-year follow-up), 87 older people (49.4% women; M age = 65.08, SD = 4.54 at Wave 1) completed a neuropsychological battery and the Perceived Stress Scale (PSS), and provided saliva samples on two (Wave 1) and three (Wave 2) consecutive days to mea…

Estructura bancaria y desigualdad de renta. La banca cooperativa marca la diferencia

2021

En este trabajo se estudia la relación existente entre tres diferentes estructuras bancarias (bancos cooperativos, bancos comerciales y cajas de ahorro) y la desigualdad de renta. El estudio basado en datos panel utiliza modelos estáticos y dinámicos y analiza el conjunto de la Eurozona con un total de 19 países y 2.253 bancos para un periodo temporal comprendido entre 2010 y 2019. Los resultados muestran que solo los bancos cooperativos reducen la desigualdad en contraposición a los bancos comerciales y las cajas de ahorro. Además, estos son robustos entre diferentes metodologías empeladas y utilizando distintos indicadores de desigualdad. Asimismo, los resultados apuntan a que la relación…

Soft-dielectron excess in proton-proton collisions at $\sqrt{s}$ = 13 TeV

2021

Physical review letters 127(4), 042302 (2021). doi:10.1103/PhysRevLett.127.042302

Binding and Reactivity of a Nitrile Oral Inhibitor of SARS-CoV-2 Main Protease Revealed by Computational Simulations

2021

We present a detailed analysis of the binding mode and reactivity of the novel oral inhibitor PF-07321332 developed against SARS-CoV-2 3CL protease. Classical and QM/MM Molecular Dynamics simulations are used to quantify the contributions to the binding free energy and the reaction mechanism for covalent inhibition. The small size of the nitrile warhead conferes additional advantadges to this inhibitor.

Impaired Binding to Junctophilin-2 and Nanostructural Alteration in CPVT Mutation

2021

Rationale: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare disease, manifested by syncope or sudden death in children or young adults under stress conditions. Mutations in the Ca 2+ release channel/RyR2 (type 2 ryanodine receptor) gene account for about 60% of the identified mutations. Recently, we found and described a mutation in RyR2 N-terminal domain, RyR2 R420Q . Objective: To determine the arrhythmogenic mechanisms of this mutation. Methods and Results: Ventricular tachycardias under stress conditions were observed in both patients with catecholaminergic polymorphic ventricular tachycardia and knock-in mice. During action potential recording (by patch-clamp in …

Interdisciplinary management of peripheral arteriovenous malformations: review of the literature and current proceedings.

2021

Arteriovenous malformations (AVMs) are a rare congenital vascular disorder. They represent a fast-flow vascular malformation. Clinically, AVMs present a heterogenous expression and can affect every part of the body. Here, we will solely focus on extracranial AVMs. Generally, AVMs progress with the patient's age. Patients often suffer from pulsation, skin discoloration, pain, ulceration, bleeding, and disfigurement. Diagnostic tools include color-coded duplex sonography, MRI and CT imaging, as well as the clinical examination. 4D dynamic perfusion-computed tomography may help in the interventional planning. Digital subtraction angiography is required during interventional therapy. AVMs pose …

Somatic experience of emotion in emotionally focused couple therapy: Experienced trainer therapists' views and experiences.

2021

In general, arousal of emotions is often felt and expressed as a somatic experience in the body. In Emotionally Focused Couple Therapy (EFT), the deepening of emotional experiencing enables therapeutic change. This research explores the experiences of eight experienced EFT trainer therapists regarding their somatic experiences in their work with couples. Using interpretative phenomenological analysis of transcribed in-depth interviews, this research data yielded three core themes that captured therapists' experiences of using their own and couples' somatic experiences in therapy: (1) the importance and relevance of somatic experiences, (2) therapists' use of their own somatic experiences, a…

Soft-Dielectron Excess in Proton-Proton Collisions at √s = 13 TeV

2021

A measurement of dielectron production in proton-proton (pp) collisions at √s=13 TeV, recorded with the ALICE detector at the CERN LHC, is presented in this Letter. The data set was recorded with a reduced magnetic solenoid field. This enables the investigation of a kinematic domain at low dielectron (ee) invariant mass mee and pair transverse momentum pT,ee that was previously inaccessible at the LHC. The cross section for dielectron production is studied as a function of mee, pT,ee, and event multiplicity dNch/dη. The expected dielectron rate from hadron decays, called hadronic cocktail, utilizes a parametrization of the measured η/π0 ratio in pp and proton-nucleus collisions, assuming th…

Does business strategy and management control system fit determine performance?

2021

PurposeThis study examines the relationship between business strategy, management control system (MCS) type and performance. Does the alignment of organisation business strategy and MCS fresult in better performance?Design/methodology/approachThis study draws on the business strategy and MCS type literature to identify business strategies and MCS types. A scoring method was used to identify business strategy types and cluster analysis to identify MCS types from a sample of 80 firms and 621 firm-years of data. Analysis of variance was used analyse the differences.FindingsFour types of MCS were identified and were labelled clan, adhocracy, market and hierarchy. The sample was split into defen…

Factors associated with Pneumocystis colonization and circulating genotypes in chronic obstructive pulmonary disease patients with acute exacerbation…

2021

Abstract Pneumocystis jirovecii colonization is frequent during chronic obstructive pulmonary disease (COPD) and patients constitute potential contributors to its interhuman circulation. However, the existence of an environmental reservoir cannot be excluded. We assessed the prevalence and factors associated with Pneumocystis colonization during COPD, and studied circulation between patients and their domestic environment. Pneumocystis molecular detection and mtLSU genotyping were performed in oro-pharyngeal washes (OPW) sampled in 58 patients with COPD acute exacerbation, and in indoor dust, sampled in patients’ homes using electrostatic dust collectors (EDCs). Lung and systemic inflammati…

The Potential of Serum Exosomal hsa_circ_0028861 as the Novel Diagnostic Biomarker of HBV-Derived Hepatocellular Cancer

2021

Hepatitis B virus (HBV)-derived hepatocellular cancer (HCC) is a serious threat to human health, especially in China. There is no highly sensitive and specific HCC biomarker at present, which makes it difficult to detect HCC at the early stage. Serum exosomal circular RNAs (circRNAs) have been reported as novel diagnostic and prognostic biomarkers of cancers. In the present study, we aimed to explore the diagnostic performance of serum exosomal circRNAs for HBV-derived HCC screening. At first, many circRNAs were found to be differentially expressed in the serum exosomes of HCC individuals by microarray analysis. The validation of dysregulated circRNAs by qRT-PCR revealed that serum exosomal…

LungBEAM: A prospective multicenter study to monitor stage IV NSCLC patients with EGFR mutations using BEAMing technology

2021

Abstract Objectives The aim of LungBEAM was to determine the value of a novel epidermal growth factor receptor (EGFR) mutation test in blood based on BEAMing technology to predict disease progression in advanced non‐small cell lung cancer (NSCLC) patients treated with first‐ or second‐generation EGFR‐tyrosine kinase inhibitors (EGFR‐TKIs). Another goal was to monitor the dynamics of EGFR mutations, as well as to track EGFR exon 20 p.T790M (p.T790M) resistance during treatment, as critical indicators of therapeutic efficacy and patient survival. Methods Stage IV NSCLC patients with locally confirmed EGFR‐TKI sensitizing mutations (ex19del and/or L858R) in biopsy tissue who were candidates to…

Fast Polymeric Functionalization Approach for the Covalent Coating of MoS2 Layers

2021

We present the covalent coating of chemically exfoliated molybdenum disulfide (MoS2) based on the polymerization of functional acryl molecules. The method relies on the efficient diazonium anchoring reaction to provoke the in situ radical polymerization and covalent adhesion of functional coatings. In particular, we successfully implement hydrophobicity on the exfoliated MoS2 in a direct, fast, and quantitative synthetic approach. The covalent functionalization is proved by multiple techniques including X-ray photoelectron spectroscopy and TGA-MS. This approach represents a simple and general protocol to reach dense and homogeneous functional coatings on 2D materials.

Efficacy, tolerability, and safety of montelukast versus finasteride for the treatment of moderate acne in women: A prospective, randomized, single-b…

2021

Background Acne is a chronic inflammatory skin disease which involves the pilosebaceous unit. Tissue inflammation isone of the crucial mechanisms, amongst others. Of the various cytokines, leukotriene B4 (LT-B4) is the most potentleucocyte chemotactic mediator. Montelukast is an antagonist of the LT-B4 receptor. Finasteride is an antiandrogen whichspecifically inhibits the 5α-reductase enzyme. Aims This study aimed at comparing the efficacy, tolerability and safety of montelukast versus finasteride in the treatmentof moderate acne in women. Patients/method This randomized, single-blinded, prospective trial over 12 weeks recruited 65 female subjects with moderate acne vulgaris (Global Acne G…

Development of Children’s Actual and Perceived Motor Competence, Cardiorespiratory Fitness, Physical Activity, and BMI

2021

Purpose To examine synergistic associations between developmental trajectories of motor competence, perceived motor competence, cardiorespiratory fitness, moderate-to-vigorous physical activity (MVPA), and body mass index (BMI) from late childhood to adolescence. Methods In this 3-yr follow-up study, motor competence, perceived motor competence, cardiorespiratory fitness, MVPA, and BMI were assessed in 1167 Finnish school-age children (girls = 583, boys = 565; Mage = 11.27 ± 0.33). Moderate-to-vigorous physical activity was measured using hip-mounted accelerometers. Developmental trajectories were analyzed using latent growth curve modeling. Results The development of motor competence, card…

Fiabilidad y validez de constructo de la traducción al valenciano/catalán del Cuestionario para la Evaluación del Síndrome de Quemarse por el trabajo…

2021

The aim of this study was to evaluate the reliability and construct validity of the Valencian/Catalonian version of the Spanish Burnout Inventory (SBI) in a sample of non-university teachers from the Valencia province (Spain). The sample consisted of 1359 teachers (67.2% were women). This instrument contains 20 items distributed into four dimensions: Enthusiasm toward the job (5 items), Psychological exhaustion (4 items), Indolence (6 items) and Guilt (5 items). The psychometric properties were examined through the following analyses: confirmatory factor analysis (CFA) and reliability (Cronbach’s alpha). All items achieved appropriate values for both statistical and psychometric parameters,…

Oxidative Stress in Non-Dialysis-Dependent Chronic Kidney Disease Patients

2021

Background: Cardiovascular complications are the leading cause of morbidity and mortality at any stage of chronic kidney disease (CKD). Moreover, the high rate of cardiovascular mortality observed in these patients is associated with an accelerated atherosclerosis process that likely starts at the early stages of CKD. Thus, traditional and non-traditional or uremic-related factors represent a link between CKD and cardiovascular risk. Among non-conventional risk factors, particular focus has been placed on anaemia, mineral and bone disorders, inflammation, malnutrition and oxidative stress and, in this regard, connections have been reported between oxidative stress and cardiovascular disease…

A COLAB model Of workplace transformation in the criminal justice context

2021

AbstractThis chapter presents the COLAB model for promoting organisational learning and innovation with potential application in criminal justice-related organisations. We describe this model as a toolkit that built on the Change Laboratory model of workplace transformation but one augmented with the beneficial components of Activity Clinics, Boundary Crossing Workshops and Codesign methods and developed within the criminal justice context. Limitations and future directions for the model are discussed.

The World Food Programme and the Nobel Peace Prize 2020

2021

This article looks at some of the central strategies and activities of the WFP to combat hunger as well as identifying funding sources and beneficiaries. It also addresses some important areas and ...

Practicing Ballot Secrecy : Postal Voting and the Witness Requirement at the 2019 Finnish Elections

2021

Electoral rights belong to the core of citizenship in democratic nation-states. Voting, then, represents an actualization of the relationship between the citizen and the political community. For citizens living outside the country in which they are eligible to vote, voting signifies a rare institutional connection to the country of origin. The aim of this article is to explore the introduction of the postal vote, a new form of voting for external voters at Finnish elections, from the grassroots perspective. The study focuses on how a central policy concern, safeguarding ballot secrecy, was resolved in the policy implementation by the witness requirement, and how the individual voters subseq…

William Shakespeare

2021

International audience; L'histoire d'un fils de gantier, sans héritage ni diplôme, et qui devient le premier dramaturge de son temps, est aussi celle d'un acteur-directeur de troupe (Lord Chamberlain's Men) et d'un faiseur de comédies. Nous retracerons, extraits à l'appui, les plus célèbres d'entre elles (La mégère apprivoisée, Le songe d'une nuit d'été, La tempête...), dans cette Renaissance foisonnante et ce théâtre du Globe, à Londres

The 3-year effect of the mediterranean diet intervention on inflammatory biomarkers related to cardiovascular disease

2021

The intervention with the Mediterranean diet (MD) pattern has evidenced short-term anti-inflammatory effects, but little is known about its long-term anti-inflammatory properties at molecular level. This study aims to investigate the 3-year effect of MD interventions compared to low-fat diet (LFD) on changes on inflammatory biomarkers related to atherosclerosis in a free-living population with a high-risk of cardiovascular disease (CD). Participants (n = 285) in the PREDIMED trial were randomly assigned into three intervention groups: MD with extra-virgin olive oil (EVOO) or MD-Nuts, and a LFD. Fourteen plasma inflammatory biomarkers were determined by Luminex assays. An additional pilot st…

The Utrecht-Management of Identity Commitments Scale (U-MICS)

2021

Abstract. The current study proposed the adaptation of the Utrecht-Management of Identity Commitments Scale (U-MICS) to the religious domain as an instrument to measure both individuals’ religious identity formation processes (when a variable-centered approach is adopted) and religious identity statuses (when a person-centered approach is adopted). The scale has been tested on a sample of 727 Italian participants aged 13–65 years, by collecting evidence of score structure, convergent, and criterion-related validity. Regarding the score structure validity, we confirmed that religious identity formation consists of three processes (commitment, in-depth exploration, reconsideration of commitm…

Facilitation of Developmental Tasks in Prisons: Applying the Method of Human-Centred Co-evaluation

2021

AbstractCollaboration and learning are especially needed in times of change in the workplace. This chapter describes a novel method for developing work practices and enhancing professionals’ proactiveness through collective, participatory experimentation and evaluation. We used the method in a low-security closed prison in Finland to advance prison staff’s rehabilitation work with prisoners. The design, implementation and evaluation of the innovations prison officers introduced to advance their work (recording the inmates’ behaviour and needs into their sentence plans) are illustrated. Besides describing how the method was applied in practice, we also identify and discuss the gaps within pr…

Neuroprotective, antioxidant and antiproliferative activity of grapefruit IntegroPectin on SH-SY5Y cells

2021

AbstractTested in vitro on SH-SY5Y neuroblastoma cells, grapefruit IntegroPectin is a powerful neuroprotective, antioxidant and antiproliferative agent. The strong antioxidant properties of grapefruit IntegroPectin, and its ability to preserve mitochondrial membrane potential and morphology, severely impaired in neurodegenerative disorders, make this new biopolymer highly soluble in water an attractive therapeutic agent for oxidative stress-associated brain disorders. Similarly, the ability of this new citrus pectin rich in naringin, linalool, linalool oxide and limonene adsorbed at the outer surface to inhibit cell proliferation or even kill, at high doses, neoplastic cells, coupled to its…

Il monastero del Santissimo Salvatore di Palermo. Architettura e committenza dal XVI al XVIII secolo

2021

Quantitative Multispectral Imaging Differentiates Melanoma from Seborrheic Keratosis.

2021

Melanoma is a melanocytic tumor that is responsible for the most skin cancer-related deaths. By contrast, seborrheic keratosis (SK) is a very common benign lesion with a clinical picture that may resemble melanoma. We used a multispectral imaging device to distinguish these two entities, with the use of autofluorescence imaging with 405 nm and diffuse reflectance imaging with 525 and 660 narrow-band LED illumination. We analyzed intensity descriptors of the acquired images. These included ratios of intensity values of different channels, standard deviation and minimum/maximum values of intensity of the lesions. The pattern of the lesions was also assessed with the use of particle analysis. …

mHealth for the Monitoring of Brace Compliance and Wellbeing in Adolescents with Idiopathic Scoliosis: Study Protocol for a Feasibility Study

2021

Escoliosis idiopática del adolescente; Aplicación móvil; Eficacia del tratamiento Escoliosi idiopàtica de l'adolescent; Aplicació mòbil; Eficàcia del tractament Adolescent idiopathic scoliosis; Mobile application; Treatment effectiveness Attempts to optimize monitoring of brace adherence prescribed to adolescents with idiopathic scoliosis (IS) have generally relied on sensors. Sensors, however, are intrusive and do not allow the assessment of psychological and physical consequences of brace use that might underlie poor adherence. Mobile applications have emerged as alternatives to monitor brace compliance. However, the feasibility and utility of these app-based systems to assess key psychol…

Inquiry-based environments for bio-signal processing training in engineering education

2021

Active student engagement, teaching via experience in real-life settings and learning by doing, are pedagogical strategies appropriate to improve student-reasoning skills. By building models, performing investigations, examining and explaining experimental results, using theoretical and computational thinking, constructing representations, undergraduates can acquire a deeper understanding of fundamental disciplinary concepts while reinforcing transversal abilities. In this framework, Engineering courses should be designed with the final objective to develop practical skills, focusing on hands-on activities. This contribution presents two different inquiry-based learning environments recent…

Analisis Tingkat Pendidikan dan Jenis Pekerjaan Terhadap Pendapatan Kepala Keluarga (KK) di Kampung Manbesak Distrik Biak Utara Provinsi Papua

2021

This study aims to determine the effect of education level and occupation on the family income in Manbesak Village, North Biak District, Biak Regency, Papua Province. The number of samples used in this study were 77 families in Manbesak Village and the data analysis used was multiple linear regression quantitative analysis with education level and occupation as independent variables and income as the dependent variable. Based on the discussion of the research result, it can be concluded that there is a positive and significant influence between the level of education and occupation on family income in Manbesak Village with the coefficient of determination obtained at 73.3 percent.
 Pen…

Compression and load balancing for efficient sparse matrix-vector product on multicore processors and graphics processing units

2021

We contribute to the optimization of the sparse matrix-vector product by introducing a variant of the coordinate sparse matrix format that balances the workload distribution and compresses both the indexing arrays and the numerical information. Our approach is multi-platform, in the sense that the realizations for (general-purpose) multicore processors as well as graphics accelerators (GPUs) are built upon common principles, but differ in the implementation details, which are adapted to avoid thread divergence in the GPU case or maximize compression element-wise (i.e., for each matrix entry) for multicore architectures. Our evaluation on the two last generations of NVIDIA GPUs as well as In…

Faktor - Faktor Penentu Minat Mahasiswa Mahasiswa Asli Papua untuk Bekerja di Sektor Pertanian Kehutanan dan Perikanan

2021

This article aims to analyze the factors that determine the interest of indigenous Papuan students at the Faculty of Economics, University of Papua to work in the agricultural, forestry and fisheries sectors. Using a quantitative descriptive research approach, it is found that the results of the analysis show that the respondent's family environmental factor is the most dominant factor influencing a student's decision to work in the agricultural, forestry or fisheries sector. The income expectation factor also has a positive and significant effect, thus illustrating that the business prospects in the agriculture, forestry and fisheries sectors remain promising for job seekers in West Papua.…

Interorganisational Collaboration in a Norwegian Prison—Challenges and Opportunities Arising from Interagency Meetings

2021

AbstractIn prison, the provision of care and the surveillance of inmates takes place in multiple locations with several often contradictory demands. Inmates may experience a fragmentation of services because of the separate silos in which criminal justice service and mental health professionals work and the distinct ways of working that develop within these. A greater alignment between services is required. This chapter focuses on interagency meetings in a Norwegian prison. These are groups that aim to develop an holistic perspective of the inmate’s situation and problems, and are seen as an innovative way to overcome the contradiction between ‘treatment’ and ‘punishment’ prison paradigms a…

New silica based adsorbent material from rice straw and its in-flow application to nitrate reduction in waters: Process sustainability and scale-up p…

2021

Abstract This paper shows a particular example to move to a sustainable circular economical process from valorization of rice straw ashes by developing a green synthesis for obtaining a useful sub-product. This strategy can palliate negative effects of the agriculture waste practices on the environment and also the obtained silica reduced nitrate content in waters. It is demonstrated that the silica synthesis developed at lab was scalable more than a hundred times with good results. Adsorption studies of nitrate in standards and real well waters at lab scale and scaling-up provided similar results. Adsorption values near to 15 mg/g for nitrate standards and 8.5 mg/g for well water were obta…