showing 36 of ~574560 from 574555 documents
Railroad integration and uneven development on the European periphery, 1870-1910
2021
This study explores the relationship between railroad integration and regional development on the European periphery between 1870 and 1910, based on a regional dataset including 291 spatial units. Railroad integration is proxied by railroad density, while per capita GDP is used as an indicator of economic development. The period under study is of particular relevance as it has been associated with the second wave of railroad construction in Europe and also coincides with the industrialization of most of the continent. Overall, we found that railroads had a significant and positive impact on the growth of per capita GDP across Europe. The magnitude of this relationship appears to be relative…
Multi-parameters rational solutions to the mKdV equation
2021
N-order solutions to the modified Korteweg-de Vries (mKdV) equation are given in terms of a quotient of two wronskians of order N depending on 2N real parameters. When one of these parameters goes to 0, we succeed to get for each positive integer N , rational solutions as a quotient of polynomials in x and t depending on 2N real parameters. We construct explicit expressions of these rational solutions for orders N = 1 until N = 6.
Capteurs de pression plasmoniques pour aplications biomédicales
2021
International audience
EVALUATION OF AUDITORY CORTICAL PLASTICITY FROM FIRST AMPLIFICATION TO ONE YEAR OF HEARING AID USE: THE RELATIONSHIP BETWEEN AIDED CORTICAL AUDITORY …
2021
Over the last decade, aided cortical auditory evoked potentials (ACAEPs) have continued to be a focus of interest due to the lack of adequate tools to objectively assess cortical auditory activity in response to amplified stimuli. The majority of authors have investigated the direct relationship between behavioral thresholds and ACAEPs and the evolution of ACAEP waves among children with sensorineural hearing loss (SNHL) undergoing rehabilitation. In contrast, scarce data are available regarding changes in ACAEPs over time in adult hearing aid users, particularly in relation to speech perception outcomes. The main goal of this project was to investigate the relationship between ACAEPs and s…
Kirker, korona og nettbaserte gudstjenester
2021
Sammendrag Store deler av Norge ble digitale da landet nærmest stengte ned våren 2020. Denne artikkelen dreier seg om hva som skjedde da kirker og menigheter byttet kirkerommet med det digitale rom som følge av korona-pandemien. Det ble holdt gudstjenester og til og med «servert» kirkekaffe på nett. Artikkelen bygger på en undersøkelse som viser at 72 % av norske kirker og menigheter produserte nettbaserte samlinger under koronakrisen. 749 kirkeledere i hele Norge har deltatt i den omfattende kartleggingen som fant sted fra 15. april til 10. mai 2020. Dette utgjør om lag en tredel av alle registrerte menigheter og kristne forsamlinger i landet. I artikkelen presenterer og diskuterer vi f…
Disturbance-induced emigration: an overlooked mechanism that reduces metapopulation extinction risk.
2021
Emigration propensity (i.e., the tendency to leave undisturbed patches) is a key life-history trait of organisms in metapopulations with local extinctions and colonizations. Metapopulation models of dispersal evolution typically assume that patch disturbance kills all individuals within the patch, thus causing local extinction. However, individuals may instead be able to leave a patch when it is disturbed, either by fleeing before being killed or simply because the disturbance destroys the patch without causing mortality. This scenario may pertain to a wide range of organisms from horizontally transmitted symbionts, to aquatic insects inhabiting temporary ponds, to vertebrates living in fra…
La « Révolution Conservatrice » en linguistique : linguiste Staline entre « notions essentielles » et l’esprit de Weimar
2021
Fascicule en libre accès sur le site de l'éditeur - ISBN : 978-5-91674-626-6; International audience; Publié lors de la discussion linguistique de 1950, le texte de Staline laisse entendre une continuité avec la tradition, ce qui implique l’image d’une société soviétique qui a réussi à conserver son caractère «traditionnaliste» malgré des coupures historiques évidentes. Cette «continuité» serait en grande partie assurée par la langue dite nationale. Plusieurs éléments «révolutionnaires-conservateurs» du texte de Staline font penser à la métaphore de l’«Allemagne russe» comme à l’une de ses sources conceptuelles.
Wavelength-Selective Softening of Hydrogel Networks.
2021
Photoresponsive hydrogels hold key potential in advanced biomedical applications including tissue engineering, regenerative medicine, and drug delivery, as well as intricately engineered functions such as biosensing, soft robotics, and bioelectronics. Herein, the wavelength-dependent degradation of bio-orthogonal poly(ethylene glycol) hydrogels is reported, using three selective activation levels. Specifically, three chromophores are exploited, that is, ortho-nitrobenzene, dimethyl aminobenzene, and bimane, each absorbing light at different wavelengths. By examining their photochemical action plots, the wavelength-dependent reactivity of the photocleavable moieties is determined. The wavele…
AlkAniline-Seq: A Highly Sensitive and Specific Method for Simultaneous Mapping of 7-Methyl-guanosine (m7G) and 3-Methyl-cytosine (m3C) in RNAs by Hi…
2021
Epitranscriptomics is an emerging field where the development of high-throughput analytical technologies is essential to profile the dynamics of RNA modifications under different conditions. Despite important advances during the last 10 years, the number of RNA modifications detectable by next-generation sequencing is restricted to a very limited subset. Here, we describe a highly efficient and fast method called AlkAniline-Seq to map simultaneously two different RNA modifications: 7-methyl-guanosine (m7G) and 3-methyl-cytosine (m3C) in RNA. Our protocol is based on three subsequent chemical/enzymatic steps allowing the enrichment of RNA fragments ending at position n + 1 to the modified nu…
Virtual Multidisciplinary Tumor Boards: A Narrative Review Focused on Lung Cancer
2021
To date, the virtual multidisciplinary tumor boards (vMTBs) are increasingly used to achieve high-quality treatment recommendations across health-care regions, which expands and develops the local MTB team to a regional or national expert network. This review describes the process of lung cancer-specific MTBs and the transition process from face-to-face tumor boards to virtual ones. The review also focuses on the project organization's description, advantages, and disadvantages. Semi-structured interviews identified five major themes for MTBs: current practice, attitudes, enablers, barriers, and benefits for the MTB. MTB teams exhibited positive responses to modeled data feedback. Virtualiz…
Brokers in the tea trade between China and West Africa
2021
Brokers have played important roles in the trade of green tea between China and Mali, from the 19th century when tea first came to Mali up to the present. They mediate between tea buyers and sellers, work on their own account, use soft skills, knowledge and networks and make a living from the commission they gain. This article examines the work of brokers in the tea trade, the social constellations in which they are active and the scope of their activity. Based on extensive field research in Mali and China, this article shows how brokers create their own jobs in a dynamic business landscape, which is often delimited by governmental policies, competing entrepreneurial activities and social …
false
2021
Introduction Niemann-Pick type C (NPC) is a lysosomal storage disease that is progressive and life-limiting, with an estimated incidence of 1:120,000 live births. In addition to systemic manifestation with (hepato-)splenomegaly, there are a number of neurological manifestations (ataxia, dysarthria, dementia, cataplexy, epileptic seizures, and psychiatric disorders). Characteristic is vertical supranuclear gaze palsy, which is often overlooked. Early diagnosis and start of therapy improve quality of life. This study aimed to characterize oculomotor dysfunction of NPC patients, and to provide ophthalmologic data including retinal imaging. Methods Eighteen patients with biochemically or genet…
Phonoritons as Hybridized Exciton-Photon-Phonon Excitations in a Monolayer h -BN Optical Cavity
2021
[EN] A phonoriton is an elementary excitation that is predicted to emerge from hybridization between exciton, phonon, and photon. Besides the intriguing many-particle structure, phonoritons are of interest as they could serve as functional nodes in devices that utilize electronic, phononic, and photonic elements for energy conversion and thermal transport applications. Although phonoritons are predicted to emerge in an excitonic medium under intense electromagnetic wave irradiation, the stringent condition for their existence has eluded direct observation in solids. In particular, on-resonance, intense pumping schemes have been proposed, but excessive photoexcitation of carriers prevents op…
crystal structures of homooligomers of collagen type iv. alpha3nc1
2021
crystal structures of homooligomers of collagen type iv. alpha5nc1
2021
Direct-acting antiviral agents and risk of Hepatocellular carcinoma: Critical appraisal of the evidence
2021
Direct-acting antivirals (DAAs) revolutionized the treatment of chronic HCV-related disease achieving high rates of sustained virological response (SVR), even in advanced cirrhosis, with modest contraindications and a low rate of adverse events. However, the risk of hepatocellular carcinoma (HCC) persists due to the underlying chronic liver disease, both in patients with and without history of HCC. Although some initial studies reported a presumptive high risk of HCC development after DAA therapy, more recent observational studies denied this hypothesis. The residual risk for HCC occurrence after HCV eradication seems being progressively reduced with time after SVR. Data on recurrence of HC…
The Structure Group and the Permutation Group of a Set-Theoretic Solution of the Quantum Yang–Baxter Equation
2021
We describe the left brace structure of the structure group and the permutation group associated to an involutive, non-degenerate set-theoretic solution of the quantum YangBaxter equation by using the Cayley graph of its permutation group with respect to its natural generating system. We use our descriptions of the additions in both braces to obtain new properties of the structure and the permutation groups and to recover some known properties of these groups in a more transparent way.
Clinical Outcomes After Aggressive Active Early Motion and Modified Kleinert Regimens: Comparison of 2 Consecutive Cohorts
2021
Background Modern multistrand repairs can withstand forces present in active flexion exercises, and this may improve the outcomes of flexor tendon repairs. We developed a simple home-based exercise regimen with free wrist and intrinsic minus splint aimed at facilitating the gliding of the flexor tendons and compared the outcomes with the modified Kleinert regimen used previously in the same institution. Methods We searched the hospital database to identify flexor tendon repair performed before and after the new regimen was implemented and invited all patients to participate. The primary outcome was total active range of motion, and secondary outcomes were Disabilities of Arm, Shoulder, and …
Relationship between clinical variables and Patient-Reported Outcomes in patients with psoriatic disease
2021
Background Psoriatic Arthritis (PsA) is a chronic inflammatory form of Arthritis associated with enthesitis, dactylitis, nail dystrophy, uveitis, and osteitis. PsA is strongly associated with comorbidities such as obesity, metabolic syndrome, and cardiovascular disease. As usual PsA patients are assessed either by rheumatologist or dermatologist but a multiprofessional assessment for those subjects is important to improve their disease control and their quality-of-life. The multidimensional assessment is a new model of care for PsA patients in which a multiprofessional team (rheumatologist, dermatologist, internal medicine physician, nutritionist and a phycologist) with a nurse as case mana…
Physical activity in health care professionals as a means of primary prevention of cardiovascular disease: A STROBE compliant cross-sectional study
2021
ABSTRACT: The aim of this study was to assess the physical activity level of health care professionals, as well as the differences by sex, age, academic background, and among different health care professions.This is an cross-sectional study.Health care settings in the Valencian Community, Spain.A total of 647 health care professionals.Physical activity was assessed with the European Health Interview Survey-Physical Activity Questionnaire (EHIS-PAQ) that includes the assessment of work-related physical activity, transport-related physical activity, health-enhancing physical activity, muscle-strengthening physical activity, and total physical activity.93.51% of all health care professionals …
Differences in acoustically determined sentence stress between native and L2 speakers of Finland Swedish
2021
This study describes a pilot attempt to use acoustically determined sentence stress in distinguishing native and L2 speakers of Finland Swedish at different proficiency levels. The study is part of the DigiTala project that examines and develops automatic tools for spoken L2 assessment. Stressed syllables were detected in 235 L2 and 30 L1 speech samples using combinations of f0, intensity, and duration. Differences were found in the relative number of stressed syllables between native and L2 speakers using f0 and duration or all three features. Further research with more consistent speech data is needed to establish reliable automatic measures of sentence stress. nonPeerReviewed
Isomeric states in Rf256
2021
The question of the number and origin of isomeric states in $^{256}\mathrm{Rf}$ arose from two independent experiments but remained unanswered for a decade. To shed light on this puzzle, we studied isomeric decay in $^{256}\mathrm{Rf}$ by measuring conversion electrons with fast fully digital electronics. $^{256}\mathrm{Rf}$ was produced in the fusion-evaporation reactions of $^{50}\mathrm{Ti}+^{207}\mathrm{Pb}$ and $^{50}\mathrm{Ti}+^{208}\mathrm{Pb}$ at the gas-filled recoil separator TransActinide Separator and Chemistry Apparatus. Among a total of 120 decays of $^{256}\mathrm{Rf}$, we detected 22 and 12 decays proceeding through one and two isomeric states. Half-lives of the low- and hi…
Improving the Downwind Sail Design Process by Means of a Novel FSI Approach
2021
The process of designing a sail can be a challenging task because of the difficulties in predicting the real aerodynamic performance. This is especially true in the case of downwind sails, where the evaluation of the real shapes and aerodynamic forces can be very complex because of turbulent and detached flows and the high-deformable behavior of structures. Of course, numerical methods are very useful and reliable tools to investigate sail performances, and their use, also as a result of the exponential growth of computational resources at a very low cost, is spreading more and more, even in not highly competitive fields. This paper presents a new methodology to support sail designers in ev…
Structural mapping of GABRB3 variants reveals genotype-phenotype correlations
2021
AbstractPurposePathogenic variants in GABRB3 have been associated with a spectrum of phenotypes from severe developmental disorders and epileptic encephalopathies to milder epilepsy syndromes and mild intellectual disability. In the present study, we analyzed a large cohort of individuals with GABRB3 variants to deepen the phenotypic understanding and investigate genotype-phenotype correlations.MethodsThrough an international collaboration, we analyzed electro-clinical data of unpublished individuals with variants in GABRB3 and we reviewed previously published cases. All missense variants were mapped onto the 3D structure of the GABRB3 subunit and clinical phenotypes associated with the dif…
Synthesis and Catalytic Use of Polar Phosphinoferrocene Amidosulfonates Bearing Bulky Substituents at the Ferrocene Backbone
2021
International audience; Anionic phosphinoferrocene amidosulfonates bearing sterically demanding t-butyl substituents in positions 3 and 3' of the ferrocene scaffold, viz. rac-(Et3NH)[Fe(η5-tBuC5H3PR2)(η5-tBuC5H3C(O)NHCH2SO3)] (R = phenyl and cyclohexyl) were synthesized by amidation of the corresponding phosphinocarboxylic acids, [Fe(η5-tBuC5H3PR2)(η5-tBuC5H3CO2H)]. These ditopic polar phosphinoferrocenes and their non-t-butylated analogues have been used as lig-ands to prepare zwitterionic (η3-allyl)palladium(II) complexes [Pd(η3-C3H5){Fe(η5-R'C5H3PR2)(η5-R'C5H3C(O)NHCH2SO3)}] (R' = H, tBu, R = Ph, Cy). Depending on the isolation procedure and crystallization condi-tions, some complexes we…
Lapsiperheiden hyvinvointi koronapandemian aikana: Osaraportti 1: Aineistonkeruu, metodit ja vastaajat
2021
Tämä osaraportti esittelee Jyväskylän yliopiston yhteistyössä Terveyden ja hyvinvoinnin laitoksen (THL) kanssa toteuttaman Varhaiskasvatus ja koronapandemia -hankkeen kyselytutkimuksen toteutuksen ja vastaajatietoja. Kysely ajoittui vuosien 2020–2021 vaihteeseen, ja sen kohderyhmänä olivat noin viisivuotiaiden lasten vanhemmat. Kysely käsitteli vanhempien työtä, työn ja perheen yhteensovittamista, vanhemmuutta, noin viisivuotiaan lapsen hoito- ja varhaiskasvatusjärjestelyjä, terveyttä ja kehitystä sekä koronapandemiaa. Kyselyssä tiedusteltiin näihin liittyviä asioita kolmelta eri ajankohdalta: vastaushetkellä eli vuoden 2020 marras–joulukuussa tai vuoden 2021 tammikuussa, kevään 2020 korona…
Insights on the coupling between vibronically active molecular vibrations and lattice phonons in molecular nanomagnets
2021
Spin-lattice relaxation is a key open problem to understand the spin dynamics of single-molecule magnets and molecular spin qubits. While modelling the coupling between spin states and local vibrations allows to determine the more relevant molecular vibrations for spin relaxation, this is not sufficient to explain how energy is dissipated towards the thermal bath. Herein, we employ a simple and efficient model to examine the coupling of local vibrational modes with long-wavelength longitudinal and transverse phonons in the clock-like spin qubit [Ho(W$_5$O$_{18}$)$_2$]$^{9-}$. We find that in crystals of this polyoxometalate the vibrational mode previously found to be vibronically active at …
Morphological and Physiological Root Traits and Their Relationship with Nitrogen Uptake in Wheat Varieties Released from 1915 to 2013
2021
Identifying genotypes with a greater ability to absorb nitrogen (N) may be important to reducing N loss in the environment and improving the sustainability of agricultural systems. This study extends the knowledge of variability among wheat genotypes in terms of morphological or physiological root traits, N uptake under conditions of low soil N availability, and in the amount and rapidity of the use of N supplied with fertilizer. Nine genotypes of durum wheat were chosen for their different morpho-phenological characteristics and year of their release. The isotopic tracer 15N was used to measure the fertilizer N uptake efficiency. The results show that durum wheat breeding did not have univ…
From Face-to-Face to Online UDeL Camps: Supporting Staff at Higher Education Institutions in Developing Universal Design for eLearning (UDeL)
2021
The TINEL Project is running a series of camps for staff at higher education institution to support them in developing inclusive eLearning. The first camp was conducted face-to-face, but the coronavirus pandemic meant that the second camp was conducted online. This created a case study in inclusive eLearning in itself and allowed us to experience and reflect on the challenges and opportunities of inclusive online teaching and learning. This paper presents the structure and content of the two camps, our reflections on moving from a face-to-face to an online situation and our elaboration how the UDL principles apply to eLearning to create Universal Design for eLearning (UDeL). We found that b…
The patient with autoimmune disorders
2021
Impact of Ecklonia maxima Seaweed Extract and Mo Foliar Treatments on Biofortification, Spinach Yield, Quality and NUE
2021
Seaweed extract (SE) application is a contemporary and sustainable agricultural practice used to improve yield and quality of vegetable crops. Plant biofortification with trace element is recognized as a major tool to prevent mineral malnourishment in humans. Mo deficiency causes numerous dysfunctions, mostly connected to central nervous system and esophageal cancer. The current research was accomplished to appraise the combined effect of Ecklonia maxima brown seaweed extract (SE) and Mo dose (0, 0.5, 2, 4 or 8 µmol L−1) on yield, biometric traits, minerals, nutritional and functional parameters, as well as nitrogen indices of spinach plants grown in a protected environment (tunnel). Head f…
Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma
2021
The invasive tumor front (the tumor–host interface) is vitally important in malignant cell progression and metastasis. Tumor cell interactions with resident and infiltrating host cells and with the surrounding extracellular matrix and secreted factors ultimately determine the fate of the tumor. Herein we focus on the invasive tumor front, making an in-depth characterization of reticular fiber scaffolding, infiltrating immune cells, gene expression, and epigenetic profiles of classified aggressive primary uterine adenocarcinomas (24 patients) and leiomyosarcomas (11 patients). Sections of formalin-fixed samples before and after microdissection were scanned and studied. Reticular fiber archit…
Frame-Semantics meets Multilingual Legal Terminology. Theoretical Principles Based on a German-French Case Study
2021
International audience; Terminology aims primarily at elaborating standardized notions for the various complex concepts within specialized fields, intending to separate clearly defined technical terms from general lexical units that are used in every-day situations, with yet a wide range of vocabulary, that is specialized to some extent but cannot be delimited by terminological standards, emerging in between (ten Hacken 2010, 2015). For legal experts, for instance, the elaboration of precisely determined legal terms contributes to an overall specific understanding of legal concepts regardless of the possible ambiguities the same term may have in a general setting. At the same time, a variet…
Polybutylene succinate artificial scaffold for peripheral nerve regeneration
2021
Regeneration and recovery of nerve tissues are a great challenge for medicine, and positively affect the quality of life of patients. The development of tissue engineering offers a new approach to the problem with the creation of multifunctional artificial scaffolds that act on various levels in the damaged tissue, providing physical and biochemical support for the growth of nerve cells. In this study, the effects of the use of a tubular scaffold made of polybutylene succinate (PBS), surgically positioned at the level of a sciatic nerve injured in rat, between the proximal stump and the distal one, was investigated. Scaffolds characterization was carried out by scanning electron microscopy …
Table ronde : DEPHY fait-il école ? Exemples d'appropriation de ces expériences au sein du monde agricole : conseil stratégique phytos des Chambres d…
2021
National audience
Més enllà de la doble hèlix: L’estructura G-quàdruplex de l’ADN
2021
L’ADN es la biomolecula fonamental per al correcte funcionament cel·lular i fins fa poc s’ha associat a l’estructura de doble helix descoberta fa mes de seixanta anys per Crick, Watson i Franklin. Tanmateix, s’han descrit altres estructures i conformacions diferents que l’ADN pot adoptar com els G-quadruplex. Aquests G-quadruplex es formen en regions del genoma riques en guanines amb una estructura tetramera i controlen processos biologics com l’expressio genetica, la proteccio contra l’envelliment o la transmissio de la informacio neuronal. En aquest article descrivim les seues caracteristiques quimiques i estructurals a mes d’introduir les seues principals funcions cel·lulars. Per finalit…