showing 36 of ~574560 from 574555 documents
Metabolic Aspects of Migraine: Association With Obesity and Diabetes Mellitus
2021
Migraine is a disabling neurovascular disorder, characterized by moderate to severe unilateral headaches, nausea, photophobia, and/or phonophobia, with a higher prevalence in women than in men, which can drastically affect the quality of life of migraine patients. In addition, this chronic disorder is related with metabolic comorbidities associated with the patient's lifestyle, including obesity and diabetes mellitus (DM). Beyond the personal and socioeconomic impact caused by migraine, obesity and DM, it has been suggested that these metabolic disorders seem to be related to migraine since: (i) they are a risk factor for developing cardiovascular disorders or chronic diseases; (ii) they ca…
Signatures of primordial black hole dark matter at DUNE and THEIA
2021
Primordial black holes (PBHs) are a potential dark matter candidate whose masses can span over many orders of magnitude. If they have masses in the $10^{15}-10^{17}$ g range, they can emit sizeable fluxes of MeV neutrinos through evaporation via Hawking radiation. We explore the possibility of detecting light (non-)rotating PBHs with future neutrino experiments. We focus on two next generation facilities: the Deep Underground Neutrino Experiment (DUNE) and THEIA. We simulate the expected event spectra at both experiments assuming different PBH mass distributions and spins, and we extract the expected 95% C.L. sensitivities to these scenarios. Our analysis shows that future neutrino experime…
Prognostic and clinicopathological significance of tumor-stroma ratio in head and neck squamous cell carcinoma:a systematic review
2021
Analysis of the tumor microenvironment has been proposed as a strategy for the treatment and prognosis of different neoplastic processes. A grading system based on the tumor-stroma ratio (TSR), which evaluates the proportion of stroma in relation to neoplastic parenchyma at the invasion front, has shown a strong prognostic value in different neoplastic processes. The aim of the present systematic review was to understand the role of the TSR in head and neck squamous cell carcinoma (HNSCC), evaluating its correlation with clinical and prognostic parameters. An electronic search was performed in PubMed/Medline, Web of Science, Science Direct, Scopus, Embase, and the Cochrane Collaboration Lib…
Imaging of Substantia Nigra in Parkinson's Disease: A Narrative Review.
2021
Parkinson’s disease (PD) is a progressive neurodegenerative disorder, characterized by motor and non-motor symptoms due to the degeneration of the pars compacta of the substantia nigra (SNc) with dopaminergic denervation of the striatum. Although the diagnosis of PD is principally based on a clinical assessment, great efforts have been expended over the past two decades to evaluate reliable biomarkers for PD. Among these biomarkers, magnetic resonance imaging (MRI)-based biomarkers may play a key role. Conventional MRI sequences are considered by many in the field to have low sensitivity, while advanced pulse sequences and ultra-high-field MRI techniques have brought many advantages, partic…
Identifying Biomarkers for Biological Age: Geroscience and the ICFSR Task Force
2021
The International Conference on Frailty and Sarcopenia Research Task Force met in March 2020, in the shadow of the COVID-19 pandemic, to discuss strategies for advancing the interdisciplinary field of geroscience. Geroscience explores biological mechanisms of aging as targets for intervention that may delay the physiological consequences of aging, maintain function, and prevent frailty and disability. Priorities for clinical practice and research include identifying and validating a range of biomarkers of the hallmarks of aging. Potential biomarkers discussed included markers of mitochondrial dysfunction, proteostasis, stem cell dysfunction, nutrient sensing, genomic instability, telomere d…
Benefits and Challenges of Digitalization: An Expert Study on Norwegian Public Organizations
2021
The implementation of and research on digital transformation in the context of public organizations have increased substantially in the past few years. A wide range of drivers, benefits, and challenges associated with digitalization have been suggested in the literature. However, these suggestions appear fragmented and disconnected, and do not offer a clear overview of the main drivers, challenges, and benefits. Moreover, research in this regard in the Norwegian and Scandinavian contexts is lacking. Therefore, there is a need to clarify the drivers, benefits, and challenges of digital transformation. To address this need, seven Norwegian public organizations were investigated by gathering d…
Heuristic Algorithm for the Analysis of Fast Field Cycling (FFC) NMR Dispersion Curves
2021
Evaluation of nuclear magnetic relaxation dispersion (NMRD) curves obtained by the fast field cycling nuclear magnetic resonance (FFC-NMR) relaxometry technique is a valuable tool for analyzing the microscopic dynamics of condensed matter systems. However, quantitative data analysis involves several conceptual and practical issues. Moving forward from previous literature approaches, we propose a new analysis method, relying on the elaboration of the inverse integral transform of the NMRD curve. Our approach results in a true heuristic method, able to unambiguously individuate the dynamic domains in the system, thereby avoiding the possible introduction of any element of discretion. The anal…
About the role of Galois groups in TGD framework
2021
This article was inspired by the inverse problem of Galois theory. Galois groups are realized as number theoretic symmetry groups realized physically in TGD a symmetries of space-time surfaces. Galois confinement is as analog of color confinement is proposed in TGD inspired quantum biology. Two instances of the inverse Galois problem, which are especially interesting in TGD, are following: Q1: Can a given finite group appear as Galois group over Q? The answer is not known. Q2: Can a given finite group G appear as a Galois group over some EQ? Answer to Q2 is positive as will be found and the extensions for a given G can be explicitly constructed.
Clinical‑dermoscopic similarities between atypical nevi and early stage melanoma
2021
Atypical (Clark) nevi are benign tumors that may be considered precursors of melanoma. Many studies acknowledge a linear progression from typical to atypical nevi that eventually transform into melanoma. It is often challenging to differentiate a Clark nevus from melanoma, especially in its early stages, due to their clinical, dermoscopic, and histological resemblance. Dermoscopy is a powerful tool in early melanoma diagnosis, but it is a subjective method of examination. Therefore, the use of dermoscopic algorithms and checklists can overcome this issue. In the case of a difficult diagnosis, since both dermoscopy and histopathological exam are subjective methods of examination, modern mole…
In Situ Regeneration of Copper-Coated Gas Diffusion Electrodes for Electroreduction of CO2 to Ethylene
2021
This research was funded by the European Union’s Horizon 2020 research and innovation program under grant agreement No 768789 as well as by the Polish National Centre of Science under grant no 2017/26/D/ST8/00508. The Institute of Solid State Physics, University of Latvia, as a center of excellence, has received funding from the European Union’s Horizon 2020 Framework Programme H2020-WIDESPREAD-01-2016-2017-TeamingPhase2 under grant agreement no. 739508, project CAMART2.
Cluster development and regional industrial restructuring: agency and asset modification
2021
The paper presents a novel theoretical framework to analyse the emergence and growth of industrial clusters. The framework focuses on the role of change agency for the modification of assets that i...
Communication intitulée « La construction des imaginaires urbains : le cas de la ville d’Autun ».
2021
International audience
Spectral Clustering Reveals Different Profiles of Central Sensitization in Women with Carpal Tunnel Syndrome
2021
Identification of subgroups of patients with chronic pain provides meaningful insights into the characteristics of a specific population, helping to identify individuals at risk of chronification and to determine appropriate therapeutic strategies. This paper proposes the use of spectral clustering (SC) to distinguish subgroups (clusters) of individuals with carpal tunnel syndrome (CTS), making use of the obtained patient profiling to argue about potential management implications. SC is a powerful algorithm that builds a similarity graph among the data points (the patients), and tries to find the subsets of points that are strongly connected among themselves, but weakly connected to others.…
Proper assignation of reactivation in a COVID-19 recurrence initially interpreted as a reinfection
2021
A 77-year-old-male (Case R) who had had a previous diagnosis of mild COVID-19 episode, was hospitalized 35 days later. On Day 23 post-admission, he developed a second COVID-19 episode, now severe, and finally died. Initially, Case R COVID-19 recurrence was interpreted as a reinfection due to the exposure to a SARS-CoV-2 RT-PCR-positive room-mate. However, whole-genome-sequencing indicated that case R recurrence corresponded to a reactivation of the strain involved in his first episode. Case R reactivation had major consequences, leading to a more severe episode, and causing a subsequent transmission to another two hospitalized patients, one of them with fatal outcome.
Un itinerario UNESCO in crescita. ‘Palermo arabo-normanna e le cattedrali di Cefalù e Monreale’, dal riconoscimento del 2015 al dibattito attuale
2021
ITALIANO: La World Heritage List riconosce in Sicilia sette siti, ultimo in ordine di tempo è l’itinerario ‘Palermo arabo-normanna e le cattedrali di Cefalù e Monreale’ (2015) che include dieci monumenti selezionati per le «condizioni d’integrità, autenticità e buono stato di conservazione». Nel 2018 la concomitanza delle manifestazioni ‘Palermo capitale della cultura’ e ‘Manifesta’ hanno contribuito ad ampliare il dibattito sulla consapevolezza e la valorizzazione del patrimonio, attraverso una visione urbana delle reti riconosciute. / ENGLISH: The World Heritage List includes seven Sicilian sites, the last in order of time to berecognized is the ‘Arab-Norman Palermo and the Cathedral Chur…
A multi-purpose, multi-rotor drone system for long-range and high-altitude volcanic gas plume measurements
2021
A multi-rotor drone has been adapted for studies of volcanic gas plumes. This adaptation includes improved capacity for high-altitude and long-range, real-time SO2 concentration monitoring, long-range manual control, remotely activated bag sampling and plume speed measurement capability. The drone is capable of acting as a stable platform for various instrument configurations, including multi-component gas analysis system (MultiGAS) instruments for in situ measurements of SO2, H2S, and CO2 concentrations in the gas plume and portable differential optical absorption spectrometer (MobileDOAS) instruments for spectroscopic measurement of total SO2 emission rate, remotely controlled gas samplin…
Modulating Long Term Memory at Late-Encoding Phase: An rTMS Study
2021
Despite a huge effort of the scientific community, the functioning of Long-Term Memory (LTM) processes is still debated and far from being elucidated. Functional and neurophysiological data point to an involvement of Dorsolateral Prefrontal Cortex (DLPFC) in both encoding and retrieval phases. However, the recently proposed Explicit/Implicit Memory Encoding and Retrieval (EIMER) model proposes that LTM at the encoding phase consists of anatomically and chronologically different sub-phases. On this basis, we aimed to investigate the role of right DLPFC during a late-encoding phase by means of low-frequency rTMS. Thirty right-handed healthy subjects were divided into three experimental groups…
Examination of the Helminth Fauna of the Bermuda Skink, Plestiodon longirostris (Scincidae), Utilizing Faecal Analysis
2021
Plestiodon longirostris is a critically endangered endemic skink living in the Bermuda archipelago. To know their intestinal parasites and evaluate the role that they may have in the conservation of the species, we have carried out a faecal analysis of some samples obtained from several populations. This type of analysis is presented as the most suitable for threatened species. The results show that P. longirostris has incorporated parasites from introduced species in Bermuda, and it is a competent host for these parasites. Nevertheless, the low prevalence of infection of these parasites suggests that they are not actually a threat to the endemic skink populations.
Relations entre mécanismes de défense et variabilité de fréquence cardiaque
2021
National audience
Current advances and novel research on minimal invasive techniques for musculoskeletal disorders.
2021
Abstract The present review summarized the current advances and novel research on minimal invasive techniques for musculoskeletal disorders. Different invasive approaches were proposed in the physical therapy field for the management of musculoskeletal disorders, such as ultrasound-guided percutaneous needle electrolysis, dry needling, acupuncture and other invasive therapy techniques, discussing about their worldwide status, safety and interventional ultrasound imaging. Indeed, dry needling may be one of the most useful and studies invasive physical therapy applications in musculoskeletal disorders of different body regions, such as back, upper limb, shoulder, arm, hand, pelvis, lower limb…
Advanced Giant Magnetoresistance (GMR) sensors for Selective-Change Driven (SCD) circuits
2021
Nowadays, bio-inspiration is driving novel sensors designs, beyond vision sensors. By taking advantage of their compatibility with standard CMOS technologies, the integration of giant magneto-resistance (GMR) based magnetic sensors within such event-driven approaches is proposed. With this aim, several topologies of such GMR sensors have been designed, fabricated and characterized. In addition, integrated circuit interfaces of a standard CMOS technology are also proposed. Their suitability for this approach is then demonstrated by means of Cadence IC simulations.
Nominal Agreement in L2 Speakers of Italian: Suggestions for a Teaching Plan
2021
International audience; This paper addresses the topic of adult acquisition of nominal agreement in Italian, a crucial issue in teaching Italian as Second/Foreign Language. Building on a corpus containing spontaneous and semi-spontaneous production data from two advanced L2-speakers of Italian, I show that nominal agreement can be problematic even in the last stages of the acquisition process. The discussion of the instances of missing agreement in the corpus suggests that these are not due to a missing knowledge of the agreement rules in Italian, but instead on processing and production. In particular, some contexts prove to be more difficult than others: gender agreement (i.e., agreement …
‘Ordinary’ and ‘diverse’ families : A case study of family discourses by Finnish early childhood education and care administrators
2021
The increased family diversity is a major global trend. Although family configurations are also diverse in contemporary Finland, it has been argued that Finnish family policies and institutional understanding of family life continues to focus on the heteronormative two-parent family with a native Finnish background. To address this issue, we analysed Finnish family discourses through qualitative interviews with early childhood education and care administrators (n = 47), applying a discourse analytic framework. Our results suggest that families are discussed through two divergent but interwoven discourses, i.e. the discourse of ordinary families and that of diverse families. The former focus…
Orson Welles: cinéaste littéraire et aventurier
2021
International audience; Orson Welles appelait le 7e art « Un ruban de rêves ». Ses films lui valurent triomphes et désaveux. Tel "Citizen Kane", qui le consacra, puis le fit déchoir d’Hollywood. Sa carrière sera celle d’un réalisateur prodige, d’un acteur mythique et d’un pionnier de l’Entertainment. Raisons de plus pour aborder ce Maverick de génie au prisme de Shakespeare, Kafka et Cervantes (qu’il porta à l’écran), et d’une Amérique réunissant vrais amis (John Huston, Antonio Ordonez), femmes sublimes (Rita Hayworth, Marlène Dietrich), et hommes d’affaires redoutables (William Randolph Hearst), qui firent et défirent sa légende.
Brand Alliances: a Network Perspective with application to the fashion industry
2021
Hyperpolarization of cis ‐ 15 N 2 ‐Azobenzene by Parahydrogen at Ultralow Magnetic Fields**
2021
The development of nuclear spins hyperpolarization, and the search for molecules that can be efficiently hyperpolarized is an active area in nuclear magnetic resonance. In this work we present a detailed study of SABRE SHEATH (signal amplification by reversible exchange in shield enabled alignment transfer to heteronuclei) experiments on 15 N2 -azobenzene. In SABRE SHEATH experiments the nuclear spins of the target are hyperpolarized through transfer of spin polarization from parahydrogen at ultralow fields during a reversible chemical process. Azobenzene exists in two isomers, trans and cis. We show that all nuclear spins in cis-azobenzene can be efficiently hyperpolarized by SABRE at suit…
A Setup for Microscopic Studies of Ultrasounds Effects on Microliters Scale Samples: Analytical, Numerical and Experimental Characterization
2021
International audience; Sonoporation is the process of cell membrane permeabilization, due to exposure to ultrasounds. There is a lack of consensus concerning the mechanisms of sonoporation: Understanding the mechanisms of sonoporation refines the choice of the ultrasonic parameters to be applied on the cells. Cells’ classical exposure systems to ultrasounds have several drawbacks, like the immersion of the cells in large volumes of liquid, the nonhomogeneous acoustic pressure in the large sample, and thus, the necessity for magnetic stirring to somehow homogenize the exposure of the cells. This article reports the development and characterization of a novel system allowing the exposure to …
Enabling long-term stable FAPb1-xSrxI3 quantum dots with high optical performance: the effect of Sr2+ doping
2021
Family Relationships, Dialogue, and Philosophy for Children:
2021
The paper deals with the importance of words and dialogue in family education. In the first part, some evidence of an action research is presented – shaped in a hermeneutic phenomenological framework and thanks to the Philosophy for Children method and materials. Then some key words are pointed out, meant as formative goals for parents’ educational support, so as to highlight the importance of dialogue among generations and, mainly, of the ethical responsibility of parents in education.
Back pain in a group of computer workers assessed in a physiotherapy unit
2021
BACKGROUND: Modern society work implies computer-based activities generating back pain because of prolonged sitting positions and non-ergonomic postures. OBJECTIVE: The aim of the study was to analyse the back-pain characteristics in a group of office workers in comparison with potential risk factors. METHODS: The design of the study was retrospective; a group of 109 computer workers with back pain was selected from a private physiotherapy unit between Jan 2018 - Dec 2019. Anthropometric, occupational and behaviour data, symptoms, the diagnosis on the first visit, previous medical diagnosis and specific physical activities were collected from medical records. RESULTS: The studied group (res…
The Impact of Mergers and Acquisitions and Sustainability on Company Performance in the Pharmaceutical Sector
2021
The primary goal of this study was to determine the impact of mergers and acquisitions (M&
Iodonium complexes of the tertiary amines quinuclidine and 1-ethylpiperidine
2021
Iodonium complexes incorporating tertiary amines have been synthesised to study and explore why such species comprised of alkyl amines are relatively rare. The complexes were characterised in solution (1H and 15N NMR spectroscopy) and the solid state (SCXRD), and analysed computationally. peerReviewed
MicroRNA Interaction Networks
2021
La tesi di Giorgio Bertolazzi è incentrata sullo sviluppo di nuovi algoritmi per la predizione dei legami miRNA-mRNA. In particolare, un algoritmo di machine-learning viene proposto per l'upgrade del web tool ComiR; la versione originale di ComiR considerava soltanto i siti di legame dei miRNA collocati nella regione 3'UTR dell'RNA messaggero. La nuova versione di ComiR include nella ricerca dei legami la regione codificante dell'RNA messaggero. Bertolazzi’s thesis focuses on developing and applying computational methods to predict microRNA binding sites located on messenger RNA molecules. MicroRNAs (miRNAs) regulate gene expression by binding target messenger RNA molecules (mRNAs). Therefo…
Il microcredito e la lotta alla povertà rurale in Camerun. Il caso del Dipartimento della Lekie
2021
The moral work of becoming a professional
2021
Abstract In contemporary working life, art-based initiatives are increasingly used in organizational training and development. For artists, this has created new employment opportunities as creative entrepreneurs who provide specialist services for workplaces. In this article, we study the dynamics of such encounters through the narrated accounts of training professionals. Our data come from a professional mentoring program where the working pairs of artists and consultants shared stories about their customer projects. By using conversation analysis as a method, we analyze the way stories are interactionally accomplished in peer group sessions of the program. In particular, we analyze how pa…
Bērna radošā pašizpausme vizuālajā mākslā pirmsskolā
2021
Grāmata paredzēta topošajiem skolotājiem studiju kursam Kultūras izpratnes un pašizpausmes mākslā mācību jomas saturs un mācīšanās pieejas: vizuālās mākslas metodika un praktizējošiem pirmsskolas skolotājiem, bērnu vecākiem. Grāmata palīdzēs skolotājam mērķtiecīgi organizēt pašizpausmes procesu vizuālajā mākslā, lai bērnam veidotos vispārīgās jeb caurviju prasmes, kas ietver bērna darbības kognitīvos, emocionālos un sociālos aspektus, kuri palīdz apgūt zināšanas, izpratni un pamatprasmes cilvēka darbībai nozīmīgās jomās. Grāmatas autore ir LU Pedagoģijas, psiholoģijas un mākslas fakultātes docētāja.