showing 36 of ~574560 from 574555 documents
MetaCache-GPU: Ultra-Fast Metagenomic Classification
2021
The cost of DNA sequencing has dropped exponentially over the past decade, making genomic data accessible to a growing number of scientists. In bioinformatics, localization of short DNA sequences (reads) within large genomic sequences is commonly facilitated by constructing index data structures which allow for efficient querying of substrings. Recent metagenomic classification pipelines annotate reads with taxonomic labels by analyzing their $k$-mer histograms with respect to a reference genome database. CPU-based index construction is often performed in a preprocessing phase due to the relatively high cost of building irregular data structures such as hash maps. However, the rapidly growi…
Corrigendum to: When phenotypes fail to illuminate underlying genetic processes in fish and fisheries science
2021
Impact accelerations during a prolonged run using a microwavable self-customised foot orthosis
2021
The use of custom-made foot orthoses has been associated with numerous benefits, such as decreased impact accelerations. However, it is not known whether this effect could be due to better customisation. The present study analysed the effects of the first generation of a microwavable prefabricated self-customised foot orthosis vs. a prefabricated standard one on impact accelerations throughout a prolonged run. Thirty runners performed two tests of 30-min running on a treadmill, each one with an orthosis condition. Impact acceleration variables of tibia and head were recorded every 5 min. Microwavable self-customised foot orthosis increased the following variables in the first instants comp…
IN HOUSE PROVIDING V. RICORSO AL MERCATO: LEGITTIMI GLI OBBLIGHI DI MOTIVAZIONE PREVISTI DAL LEGISLATORE ITALIANO
2021
L'art. 192, comma 2,del Codice dei contratti pubblici impone alle stazioni appaltanti, nel caso di affidamenti in house, un obbligo di motivazione particolarmente rigoroso, la cui legittimità è stata di recente confermata dalla Corte di giustizia e dalla Corte costituzionale, sulla base di argomentazioni giuridiche verosimilmente riferibili anche all'obbligo motivazionale di cui all'art. 5 TUSP, applicabile alle ipotesi di costituzione di società pubbliche (ivi incluse quelle in house) o di acquisto di partecipazioni nelle medesime. Facendo seguito alle suddette pronunce, l'Anac ha di recente adottato delle Linee guida, che entreranno in vigore all'esito della procedura di consultazione pub…
Synthesis of (+) and (‐)‐Streptomyces coelicolor Butanolide 5 (SCB‐5)
2021
Objective health literacy skills among ninth graders in Finland : outcomes from a national learning assessment
2021
Background:Health literacy (HL) is an important determinant for maintaining and improving health throughout the lifespan. This underlines the need to monitor HL, including among adolescents, and to understand the factors explaining HL, with a view to decreasing differences in HL. The aim of this study was to objectively measure HL, and the relationship between HL and socio-demographic factors (gender, language of instruction, pupils’ educational aspirations, parents’ educational background and pupils’ school achievement) among pupils ( n = 3652) at the end of basic education in Finland.Methods:A nationally representative assessment, which included 55 items on HL, was conducted as a traditio…
Varhaiskasvatushenkilöstön käsityksiä lasten tunteiden säätelytaitojen kehittymisestä – Käytäntöön integroitu koulutus ammatillisen kehittymisen tuke…
2021
Lapset tarvitsevat aikuisen tukea oppiakseen säätelemään tunteitaan. Jotta varhaiskasvatuksen ammattilainen voi tarjota lapsille monipuolista ja sensitiivistä tunteiden säätelyn tukea osana pedagogista toimintaa, häneltä odotetaan oman roolin tiedostamista lapsen tunteiden kanssasäätelijänä. Lasten tunteiden säätelytaitojen tukeminen pedagogisessa toiminnassa rakentuu kanssasäätelijän teoreettiselle tiedolle ja vaatii sen soveltamista käytännössä. Tässä tutkimuksessa on tarkasteltu, millaisia käsityksiä varhaiskasvatushenkilöstöllä on tunteiden kanssasäätelystä, ja kuinka käsitykset muuttuvat, kun heidän tietopohjaansa tunteiden kanssasäätelystä vahvistetaan työhön integroidun koulutuskokon…
Sensitive Screening of New Psychoactive Substances in Serum Using Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry.
2021
Abstract Analysis of new psychoactive substances (NPS) still poses a challenge for many institutions due to the number of available substances and the constantly changing drug market. Both new and well-known substances keep appearing and disappearing on the market, making it hard to adapt analytical methods in a timely manner. In this study we developed a qualitative screening approach for serum samples by means of liquid chromatography--quadrupole time-of-flight mass spectrometry. Samples were measured in data-dependent auto tandem mass spectrometry mode and identified by fragment spectra comparison, retention time and accurate mass. Approximately 500 NPS, including 195 synthetic cannabino…
Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis
2021
ABSTRACT Objective: Neddylation is a druggable and reversible ubiquitin-like post-translational modification upregulated in many diseases, including liver fibrosis, hepatocellular carcinoma, and more recently, non-alcoholic fatty liver disease (NAFLD). Herein, we propose to address the effects of neddylation inhibition and the underlying mechanisms in pre-clinical models of NAFLD. Methods: Hepatic neddylation measured by immunohistochemical analysis and NEDD8 serum levels measured by ELISA assay were evaluated in NAFLD clinical and pre-clinical samples. The effects of neddylation inhibition by using a pharmacological small inhibitor, MLN4924, or molecular approaches were assessed in isolate…
Bayesian hierarchical nonlinear modelling of intra-abdominal volume during pneumoperitoneum for laparoscopic surgery
2021
Laparoscopy is an operation carried out in the abdomen or pelvis through small incisions with external visual control by a camera. This technique needs the abdomen to be insufflated with carbon dioxide to obtain a working space for surgical instruments' manipulation. Identifying the critical point at which insufflation should be limited is crucial to maximizing surgical working space and minimizing injurious effects. Bayesian nonlinear growth mixed-effects models are applied to data coming from a repeated measures design. This study allows to assess the relationship between the insufflation pressure and the intra--abdominal volume.
Reflexión en torno al encuadramiento jurídico de las personas repartidoras de plataformas digitales
2021
espanolEn este trabajo se realiza un analisis en torno a la consideracion juridica de la nueva prestacion de servicios surgida en el contexto de la actual digitalizacion, concretamente, de las personas repartidoras de las plataformas digitales. Se parte del analisis de las notas de laboralidad, especialmente, de la dependencia o subordinacion y de la ajenidad, frente a la caracterizacion de la persona trabajadora por cuenta propia. Asimismo, se realiza un estudio del Derecho comparado de nuestro entorno, concretamente, de Francia e Italia, y, a partir de todo ello, plantear propuestas regulatorias. EnglishIn this paper, it is carried out an analysis on the legal consideration of the new pro…
Determination of m¯b/m¯c and m¯b from nf=4 lattice QCD+QED
2021
We extend HPQCD's earlier ${n}_{f}=2+1+1$ lattice-QCD analysis of the ratio of $\overline{\mathrm{MS}}$ masses of the $b$ and $c$ quark to include results from finer lattices (down to 0.03 fm) and a new calculation of QED contributions to the mass ratio. We find that ${\overline{m}}_{b}(\ensuremath{\mu})/{\overline{m}}_{c}(\ensuremath{\mu})=4.586(12)$ at renormalization scale $\ensuremath{\mu}=3\text{ }\text{ }\mathrm{GeV}$. This result is nonperturbative. Combining it with HPQCD's recent lattice $\mathrm{QCD}+\mathrm{QED}$ determination of ${\overline{m}}_{c}(3\text{ }\text{ }\mathrm{GeV})$ gives a new value for the $b$-quark mass: ${\overline{m}}_{b}(3\text{ }\text{ }\mathrm{GeV})=4.513(2…
The chemical composition of the flowers essential oil of Inula crithmoides (Asteraceae) growing in aeolian islands, Sicily (Italy) and its biocide pr…
2021
Essential oils have been used for a long time in several fields of interest. Recently, they have also been applied in the conservation of Cultural Heritage to contrast biodeterioration replacing the most current biocides toxic for humans and environment. Inula crithmoides L. (syn. Limbarda crithmoides (L.) Dumort) is a halophyte species distributed along the Mediterranean coasts and it is used as an edible vegetable since the young leaves or shoots are eaten raw or cooked. Several biological properties have been determined for this plant including antimicrobial activities. In this study the volatile composition of the aerial part of an accession from the Aeolian Islands, Sicily (Italy) is d…
Lisää taitoja ja mahdollisuuksia varhaiskasvatukseen: Tavoitteena tasa-arvoisempi ja kielitietoisempi varhaiskasvatus
2021
Kasvatuksellisen ja koulutuksellisen tasa-arvon toteutuminen monikielistyvässä Suomessa edellyttää entistä kielitietoisempaa varhaiskasvatusta (Puukko ym., 2019). Monikulttuurisuuden kohtaaminen on arvioitu yhdeksi keskeisimmäksi varhaiskasvatuksen tulevaisuuden osaamistaidoksi (Karila ym., 2013), ja monikielisyyden lisääntyminen haastaa ja kannustaa kehittämään entistä sensitiivisempiä, vuorovaikutuksellisia pedagogisia käytänteitä (Karila, 2016). Teimme keväällä 2017 verkkokyselyn, jonka tavoitteena oli kerätä tietoa ja näkökulmia monikielisyyden kohtaamisesta sekä kielitietoisista työskentelytavoista suomalaisessa varhaiskasvatuksessa. Kysely oli suunnattu monikielisessä lapsiryhmässä ty…
Highly Efficient Removal of Neonicotinoid Insecticides by Thioether-Based (Multivariate) Metal–Organic Frameworks
2021
Circumventing the impact of agrochemicals on aquatic environments has become a necessity for health and ecological reasons. Herein, we report the use of a family of five eco-friendly water-stable isoreticular metal-organic frameworks (MOFs), prepared from amino acids, as adsorbents for the removal of neonicotinoid insecticides (thiamethoxam, clothianidin, imidacloprid, acetamiprid, and thiacloprid) from water. Among them, the three MOFs containing thioether-based residues show remarkable removal efficiency. In particular, the novel multivariate MOF {SrIICuII6[(S,S)-methox]1.5[(S,S)-Mecysmox]1.50(OH)2(H2O)}·36H2O (5), featuring narrow functional channels decorated with both -CH2SCH3 and -CH2…
Observational outcomes in proliferative diabetic retinopathy patients following treatment with ranibizumab, panretinal laser photocoagulation or comb…
2021
Purpose Ranibizumab monotherapy showed stronger effects on area of retinal neovascularization (NV) reduction while offering better visual acuity (VA) results than panretinal laser photocoagulation (PRP) monotherapy during the first 12 months of the PRIDE study. The second year of PRIDE was an observational, non-interventional follow-up, performed to evaluate long-term anatomical and functional outcomes in proliferative diabetic retinopathy (PDR) patients under real-life conditions, prior to the approval of ranibizumab for PDR. Methods Seventy-three PDR patients (28 from the ranibizumab group; 20 from the PRP group; 25 from the combination group) were included in the observational follow-up …
Neighbours of a family with a disabled person
2021
Nowadays, social changes include the perception not only of disability itself, but also of a family with a disabled member. These changes concern the organisation of support for the family, which functions in the entire social ecosystem, including the closest social groups, e.g., the neighbourhood. Although this neighbourhood, which is also subject to changes, can become an invaluable source of support, unfortunately, it may also become an environment that contributes to the social exclusion of a family. In this paper, the author presents selected aspects of the co-existence of people with disabilities and their families with their neighbours. The paper used research on opinions about being…
Bi-Lipschitz invariance of planar BV- and W1,1-extension domains
2021
We prove that a bi-Lipschitz image of a planar $BV$-extension domain is also a $BV$-extension domain, and that a bi-Lipschitz image of a planar $W^{1,1}$-extension domain is again a $W^{1,1}$-extension domain.
Factors affecting the level of professional development among nursing staff after the introduction of an electronic education monitoring system
2021
Background: Constant improvement of the level of education, occupational independence, and the undertaking of scientific activity, including research and publications, contribute fundamentally to the development of the nursing profession. Ministerial directives for nurses to acquire and increase qualifications gave rise to the emergence of a new job profile in which self-discipline in the scope of scientific activity and personal development is essential. Aim of the study: The study aimed to assess the factors affecting the level of professional development among nurses after the introduction of the electronic education monitoring system (SMK), including variables hindering the process of i…
Erratum: “Enhanced acoustic pressure sensors based on coherent perfect absorber-laser effect” [J. Appl. Phys. 129, 104902 (2021)]
2021
false
2021
Gambling may range from being a recreational leisure activity to a behavioral addiction. A rising number of gamblers experience adverse consequences from gambling, termed problem gambling, which may become a challenge for the individual and society. With the present research, we aimed to investigate the correlates of problem gambling. We used a large sample of more than 12,500 individuals (46% male, Mage = 48, SDage = 18) from the Household, Income, and Labour Dynamics in Australia (HILDA) Survey and analyzed sociodemographic and personality variables (Big Five, locus of control) as well as the extent of problem gambling. Findings showed that male sex and a lower level of education were rel…
Äitien palvelutyytyväisyyden rakentuminen ja yhteistyökokemukset varhaiskasvatuksessa
2021
Artikkelissa tutkitaan äitien tyytyväisyyttä noin yksivuotiaan lapsensa varhaiskasvatuspalveluun tarkastelemalla palvelutyytyväisyyden ulottuvuuksia. Lisäksi tutkitaan äitien ja varhaiskasvatuksen henkilökunnan välisen yhteistyön sekä palveluntarjoajan (yksityinen vs. kunnallinen) yhteyttä äitien palvelutyytyväisyyteen. Lopuksi tarkastellaan, eroaako yhteistyön yhteys palvelutyytyväisyyteen palveluntarjoajan mukaan. Tutkimusaineisto koostuu CHILDCARE-hankkeen kyselytutkimukseen osallistuneiden varhaiskasvatuksessa olevien yksivuotiaiden äitien vastauksista (N = 549). Analyysimenetelminä käytettiin eksploratiivista faktorianalyysia sekä hierarkkista lineaarista regressioanalyysiä. Äitien tyy…
(g−2)e,μ in an extended inverse type-III seesaw model
2021
There has been a longstanding discrepancy between the experimental measurements of the electron and muon anomalous magnetic moments and their predicted values in the Standard Model. This is particularly relevant in the case of the muon $g\ensuremath{-}2$, which has attracted a remarkable interest in the community after the long-awaited announcement of the first results by the Muon $g\ensuremath{-}2$ collaboration at Fermilab, which confirms a previous measurement by the E821 experiment at Brookhaven and enlarges the statistical significance of the discrepancy, now at $4.2\ensuremath{\sigma}$. In this paper we consider an extension of the inverse type-III seesaw with a pair of vectorlike lep…
Fate of microplastics in agricultural soils amended with sewage sludge: Is surface water runoff a relevant environmental pathway?
2021
Abstract Sewage sludge used as agricultural fertilizer has been identified as an important source of microplastics (MPs) to the environment. However, the fate of MPs added to agricultural soils is largely unknown. This study investigated the fate of MPs in agricultural soils amended with sewage sludge and the role of surface water runoff as a mechanism driving their transfer to aquatic ecosystems. This was assessed using three experimental plots located in a semi-arid area of Central Spain, which were planted with barley. The experimental plots received the following treatments: (1) control or no sludge application; (2) historical sludge application, five years prior to the experiment; and …
Comparison of 3 ionisation methods - electron ionisation, chemical ionisation and atmospheric pressure photoionisation - for the characterisation of …
2021
International audience; Gas chromatography (GC) is a reproducible, robust, selective and sensitive method to analyse volatile organic compounds (VOCs) in a wide range of applications. The separated analytes are generally characterised by mass spectrometry (MS) under vacuum conditions. The main ionisation method is the Electron Ionisation (EI): high energy exchanges occur, causing reproducible molecular fragmentations. Chemical Ionisation (CI) is another ionisation method where a reactive gas (i.e. methane or ammonia) is ionised to form reactant ions. GC-MS can also be conducted under atmospheric pressure. Atmospheric Pressure PhotoIonisation (APPI) is the most recent source [1]. Emitted pho…
Le récit postcolonial dans le cadre des études francophones : un récit parmi d’autres. À partir des Javanais de Jean Malaquais
2021
International audience; No abstract
Les chemins inattendus de la réussite étudiante
2021
International audience; Quelles sont les situations de vulnérabilité que les étudiant·es rencontrent ? Comment illustrer leur caractère réversible, qui emporte certain·es sur des chemins inattendus de la réussite ? Notre propos trouve un écho particulier...
Context-Aware RF-Energy Harvesting for IoT Networks
2021
Energy Harvesting plays a crucial role in improving the operational lifetime of IoT devices. The deployment of dedicated RF-transmitters helps in sufficient energy propagation to the sensor nodes of IoT networks. Also, energy harvesting using the deployment of such RF-transmitters is a challenging issue. In this work, two methods are proposed for the optimal placement of RF-transmitters for efficient energy harvesting in wireless sensor networks. The proposed context-aware RF-energy harvesting considers different network performance parameters such as energy-hole information, and data routing information. RF-transmitter deployment is achieved using network connectivity information in the fi…
Nudging Children and Adolescents toward Online Privacy: An Ethical Perspective
2021
The widespread practices of data collection by third-party actors pose challenges to children’s and adolescents’ privacy when they navigate digital environments. Given that the informed-consent par...
Dynamics of agency governance: Evidence from the Nuclear safety sector
2021
Public organizations are compound bodies characterized by competing endogenous dynamics of governance. This study makes two main contributions. First, it contributes to an organizational approach to studies of public policy and administration by conceptualizing compound agency governance. Second, by determining how variation in agency governance reflects endogenous organizational factors. Based on a study of the Norwegian Radiation and Nuclear Safety Authority (DSA), two observations are highlighted: Firstly, DSA staff are torn between two competing behavioural logics: A governmental and a transnational logic. Moreover, portfolios of core state powers are more closely monitored by parent m…
Characterization of key aroma compounds in Burgundy truffle
2021
International audience
Exploring the Role of Intramolecular Interactions in the Suppression of Quantum Tunneling of the Magnetization in a 3d-4f Single-Molecule Magnet.
2021
Hydroxide-bridged FeIII4LnIII2 clusters having the general formula [Fe4Ln2(μ3-OH)2(mdea)6(SCN)2(NO3)2(H2O)2]·4H2O·2MeCN {Ln = Y (1), Dy (2), mdea = N-methyldiethanolamine} were synthesized and magnetically characterized. The thermal relaxation of the magnetization for 2 and the diluted FeIII4DyIIIYIII complex 3 (with and without applied field) has been analyzed. The diluted sample shows a dominant QTM at low temperatures that can be removed with a 0.15 T dc field. Both 2 and 3 show moderately high Ueff barriers and exhibit hysteresis loops until 5 K.
Pienten lasten osallisuus vuorohoidon iltojen vuorovaikutustilanteissa
2021
Tutkimuksessa tarkastellaan, kuinka pienten lasten osallisuus toteutuu vuorohoidon iltojen vuorovaikutustilanteissa ja millaisia haasteita tähän liittyy. Aineisto kerättiin havainnoimalla 20–36 kk ikäisten lasten iltoja kahdessa erilaisessa vuoropäiväkodissa. Temaattisen analyysin perustana toimivat Lundyn (2007) kuvaamat, Yhdistyneiden Kansakuntien (YK) lapsen oikeuksien sopimuksen artiklaan 12 pohjautuvat lasten osallisuuden edellytykset. Huomion kohteena olivat erityisesti työntekijöiden toiminta ja sen lapsille luomat mahdollisuudet ilmaista mielipiteitään sekä tulla kuulluksi ja huomioiduksi. Muuttuva iltaryhmä sekä päiväkodin rutiinit ja säännöt rajoittivat toisinaan lasten osallisuud…
Isolating reactive metal-based species in Metal-Organic Frameworks - viable strategies and opportunities.
2021
Structural insight into reactive species can be achieved via strategies such as matrix isolation in frozen glasses, whereby species are kinetically trapped, or by confinement within the cavities of host molecules. More recently, Metal–Organic Frameworks (MOFs) have been used as molecular scaffolds to isolate reactive metal-based species within their ordered pore networks. These studies have uncovered new reactivity, allowed observation of novel metal-based complexes and clusters, and elucidated the nature of metal-centred reactions responsible for catalysis. This perspective considers strategies by which metal species can be introduced into MOFs and highlights some of the advantages and lim…
Corporate Resilience in face of the Covid 19: A proposition for a business resilience Index
2021
Titre du congrès : «The Future of Europe Beyond Brexit and COVID-19»; International audience
Unveiling the Ionic Diels-Alder Reactions within the Molecular Electron Density Theory
2021
The ionic Diels–Alder (I-DA) reactions of a series of six iminium cations with cyclopentadiene have been studied within the Molecular Electron Density Theory (MEDT). The superelectrophilic character of iminium cations, ω >