showing 36 of ~574560 from 574555 documents
Measurement of proton electromagnetic form factors in the time-like region using initial state radiation at BESIII
2021
Physics letters / B 817, 136328 (2021). doi:10.1016/j.physletb.2021.136328
Inkonsekvent og omskiftelig?
2021
Artikkelen undersøker hvordan historikeren P.A. Munch forholdt seg til idéen om «nordisk» nasjonalitet, og hva han mente om skandinavisme-bevegelsen da den var på sitt mest populære på midten av 1800-tallet. Skandinavismen og tanken om en fellesnordisk nasjonalitet ble aktualisert i forbindelse med de to dansk-tyske krigene i 1848–51 og 1864. Samtidig tok mange aktivt avstand fra bevegelsens ambisiøse program. Ifølge den rådende historieforskningen var den norsk-nasjonale historikeren Munch en av de fremste avstandstagerne, med unntak av en kort periode etter krigsutbruddet i 1848, da han lot seg rive med av idéen og gikk inn for svensk-norsk militærhjelp til Danmark. Denne «skandinavistisk…
La jurisdicción de Responsabilidades Políticas contra las mujeres, 1939-1945
2021
El objetivo del presente texto es profundizar en las especificidades de la represión franquista cuando esta se ejerció contra las mujeres. En concreto, incidir en las particularidades de una modalidad que a priori no realizaba una distinción en clave de género: la Ley de Responsabilidades Políticas, eje de la represión económica de posguerra. Por un lado, se recoge el porcentaje de encausadas en relación al impacto total en diferentes provincias, tratando de ofrecer claves explicativas. Igualmente, se plantea el problema de las cifras y la existencia de otras víctimas de la represión económica más difíciles de contabilizar. Finalmente, se reflexiona en torno a las particularidades de estos …
‘Strong and courageous’ but ‘constantly insecure’: dialogical self theory, intersecting identities, and Christian mixed martial arts
2021
Being a mixed martial arts fighter and a devout Christian seems to present an apparent contradiction that requires identity work to bring these identities into unity. We used Dialogical Self Theory and explored the autobiography of Ron ‘H2O’ Waterman, a professional fighter turned evangelist, to understand how the tensions between the different identities or I-positions were negotiated. We identified two I-positions, ‘Ron the Fighter’ and ‘Ron the Pater Familias’, which related differently to religion, sport, and masculinity. Importantly, the negotiations were not between MMA and faith, but between these two I-positions that served the different needs for self-enhancement and union with som…
More than a pore: How voltage-gated calcium channels act on different levels of neuronal communication regulation.
2021
ABSTRACT Voltage-gated calcium channels (VGCCs) represent key regulators of the calcium influx through the plasma membrane of excitable cells, like neurons. Activated by the depolarization of the membrane, the opening of VGCCs induces very transient and local changes in the intracellular calcium concentration, known as calcium nanodomains, that in turn trigger calcium-dependent signaling cascades and the release of chemical neurotransmitters. Based on their central importance as concierges of excitation-secretion coupling and therefore neuronal communication, VGCCs have been studied in multiple aspects of neuronal function and malfunction. However, studies on molecular interaction partners …
Lattice QCD calculation of the electroweak box diagrams for the kaon semileptonic decays
2021
We present a lattice QCD calculation of the axial $\gamma W$-box diagrams relevant for the kaon semileptonic decays. We utilize a recently proposed method, which connects the electroweak radiative corrections in Sirlin's representation to that in chiral perturbation theory. It allows us to use the axial $\gamma W$-box correction in the SU(3) limit to obtain the low energy constants for chiral perturbation theory. From first principles our results confirm the previously used low energy constants provided by the minimal resonance model with a significant reduction in uncertainties.
Nullité des délibérations : la contrariété à l'intérêt social ne suffit pas
2021
International audience; Note sous Cour de cassation (com.), 13 janvier 2021, n° 18-21.860 (F-P), Société mécanique de précision de Méreau
X-Ray Spectroscopy of Ejecta and Compact Objects in Supernova Remnants
2021
De l’impératif de la vertu politique à la préférence de Rousseau pour un gouvernement aristocratique
2021
Dans la théorie politique de Rousseau, si la forme du gouvernement importe peu, pourvu qu’il demeure subordonné au souverain, le philosophe genevois semble néanmoins accorder sa préférence à un gouvernement de type aristocratique afin de respecter cette exigence. Devant la difficulté de réunir les conditions supposées du gouvernement démocratique, et établissant la vertu politique comme principe d’une société véritablement démocratique, le raisonnement du Genevois semble le conduire à penser le gouvernement de type aristocratique comme le meilleur de tous, avec des magistrats qui gouvernent pour le bien commun et exécutent la volonté générale sans tendre à l’incarner : un gouvernement « éna…
false
2021
(1) Background: This cross-sectional study aims to compare a new and non-invasive approach using hyperspectral imaging (HSI) with the conventional modified Allen’s test (MAT) for the assessment of collateral perfusion prior to radial forearm free flap harvest in healthy adults. (2) HSI of the right hand of 114 patients was recorded. Here, three recordings were carried out: (I) basic status (perfusion), (II) after occlusion of ulnar and radial artery (occlusion) and (III) after releasing the ulnar artery (reperfusion). At all recordings, tissue oxygenation/superficial perfusion (StO2 (0–100%); 0–1 mm depth), tissue hemoglobin index (THI (0–100)) and near infrared perfusion index/deep perfusi…
The Wnt-specific astacin proteinase HAS-7 restricts head organizer formation in Hydra
2021
Abstract Background The Hydra head organizer acts as a signaling center that initiates and maintains the primary body axis in steady state polyps and during budding or regeneration. Wnt/beta-Catenin signaling functions as a primary cue controlling this process, but how Wnt ligand activity is locally restricted at the protein level is poorly understood. Here we report a proteomic analysis of Hydra head tissue leading to the identification of an astacin family proteinase as a Wnt processing factor. Results Hydra astacin-7 (HAS-7) is expressed from gland cells as an apical-distal gradient in the body column, peaking close beneath the tentacle zone. HAS-7 siRNA knockdown abrogates HyWnt3 proteo…
Measurements of the branching fractions of ψ(3686)→Σ¯0Λ+c.c. and χcJ(J=0,1,2)→ΛΛ¯
2021
Paratransgenic manipulation of a tsetse microRNA alters the physiological homeostasis of the fly’s midgut environment
2021
Tsetse flies are vectors of parasitic African trypanosomes, the etiological agents of human and animal African trypanosomoses. Current disease control methods include fly-repelling pesticides, fly trapping, and chemotherapeutic treatment of infected people and animals. Inhibiting tsetse’s ability to transmit trypanosomes by strengthening the fly’s natural barriers can serve as an alternative approach to reduce disease. The peritrophic matrix (PM) is a chitinous and proteinaceous barrier that lines the insect midgut and serves as a protective barrier that inhibits infection with pathogens. African trypanosomes must cross tsetse’s PM in order to establish an infection in the fly, and PM struc…
Lopinavir/ritonavir and darunavir/cobicistat in hospitalized covid-19 patients: Findings from the multicenter italian corist study
2021
Background: Protease inhibitors have been considered as possible therapeutic agents for COVID-19 patients.Objectives: To describe the association between lopinavir/ritonavir (LPV/r) or darunavir/cobicistat (DRV/c) use and in-hospital mortality in COVID-19 patients.Study Design: Multicenter observational study of COVID-19 patients admitted in 33 Italian hospitals. Medications, preexisting conditions, clinical measures, and outcomes were extracted from medical records. Patients were retrospectively divided in three groups, according to use of LPV/r, DRV/c or none of them. Primary outcome in a time-to event analysis was death. We used Cox proportional-hazards models with inverse probability of…
About the Use of Tag Questions in Andean Spanish
2021
This paper aims to describe the use of tag questions in the variety of Andean Spanish spoken in Bolivia. In particular, it explores the tag questions that occur in the Corpus oral del español hablado por bilingües de aymara-español. The analysis consists of two levels. On the one hand, it describes the pragmatic functions of tag questions and identifies the correlation between their distribution and their pragmatic functions. On the other hand, it focuses on the impact that social factors (the speakers’ sex, age, and education) have on the frequency of the tags. Along these lines, it displays the lack of a general sociolinguistic trend in the use of tag questions, furthermore, it shows that…
Assembling a consensus on actinic cheilitis: A Delphi study.
2021
Aims: To discuss the terminology to define and classify actinic cheilitis (AC) and to build a consensus on the diagnostic and therapeutic approaches to AC. Methods: Two-round Delphi study using a questionnaire including 34 closed sentences (9 on terminology and taxonomy, 5 on potential for malignant transformation, 12 on diagnostic aspects, 8 on treatment) and 8 open questions. Experts’ agreement was rated using a Likert scale (1–7). Results: A consensus was reached on 24 out 34 statements (73.5%) and on 5 out of 8 (62.5%) close-ended questions. The response rate was identical in both rounds (attrition of 0%). AC is the term with the highest agreement (median of 7 (strongly agree; IQR: 6–7)…
Effectiveness of removable appliances with temperature sensors in orthodontic patients: a systematic review and meta-analysis
2021
Summary Background/objective Patient compliance during orthodontic treatment is one of the factors that most affects success in the final result. The use of removable appliances is frequent at an early age and the monitoring of its use is essential to assess the collaboration of the patient. The aim of this study was to establish the effectiveness of microsensors included in removable appliances during orthodontic treatment or in the retention phase to enable a reliable and individualized follow-up of the patient. Search methods The article search was carried out in various electronic databases and journals without any language restrictions. Selection criteria Studies using microsensors int…
Impact of the union intervention in the matter of labor risks of psychosocial origin. A study purchased in Western Europe
2021
espanolEs conocido que la intervencion sindical tiene un efecto positivo sobre la reduccion de los accidentes de trabajo. Sin embargo, no existe evidencia comparable sobre su efecto en las patologias psicosomaticas. La presente investigacion estudia el impacto de la representacion de los trabajadores en materia de riesgos psicosociales, tanto en terminos agregados para el conjunto de la UE como de forma comparada entre los distintos sistemas de relaciones laborales. A tal efecto, se analizan los microdatos de una encuesta a 31.991 centros de trabajo europeos (ESENER-2), mediante diversos modelos de regresion que permitieron identificar como la presencia de representantes garantiza estandare…
Spin Crossover Metal-Organic Frameworks with Inserted Photoactive Guests: On the Quest to Control the Spin State by Photoisomerization
2021
International audience; Three Hofmann-like metal-organic frameworks {Fe(bpac)[Pt(CN)4]}•G (bpac=1,2-bis(4-pyridyl)acetylene) were synthesized with photoisomerizable guest molecules (G = trans-azobenzene, trans-stilbene or cis-stilbene) and were characterized by elemental analysis, thermogravimetry and powder X-ray diffraction. The insertion of guest molecules and their conformation were inferred from Raman and FTIR spectra and from single-crystal X-ray diffraction and confronted with computational simulation. The magnetic and photomagnetic behaviors of the framework are significantly altered by the different guest molecules and different conformations. On the other hand, photoisomerization …
Fronto-parietal homotopy in resting-state functional connectivity predicts task-switching performance
2021
Homotopic functional connectivity reflects the degree of synchrony in spontaneous activity between homologous voxels in the two hemispheres. Previous studies have associated increased brain homotopy and decreased white matter integrity with performance decrements on different cognitive tasks across the life-span. Here, we correlated functional homotopy, both at the whole-brain level and specifically in fronto-parietal network nodes, with task-switching performance in young adults. Cue-to-target intervals (CTI: 300 vs. 1200 ms) were manipulated on a trial-by-trial basis to modulate cognitive demands and strategic control. We found that mixing costs, a measure of task-set maintenance and moni…
MuPix10: First Results from the Final Design
2021
Many years of research and development of High Voltage Monolithic Active Pixel Sensors (HVMAPS) have culminated in the final design for the Mu3e pixel sensor. MuPix10 is a fully monolithic sensor with an active pixel matrix size of $20\times20\,\mathrm{mm}^2$ produced in the $180\,\mathrm{nm}$ HV-CMOS process at TSI Semiconductors. The pixel size is $80\times80\,\mathrm{\mu m}^2$. Hits are read out using a column-drain architecture and sent over up to four serial links with up to $1.6\,\left.\mathrm{Gbit}\middle/\mathrm{s}\right.$ each. By means of DC/DC converters and exclusive usage of on-chip biasing, MuPix10 is fully operable with a minimal set of electrical connections. This is an inte…
Validation of the Hungarian PHQ-15. A latent variable approach
2021
Somatic symptoms without a clear-cut organic or biomedical background, also called "medically unexplained" or "somatoform" symptoms, are frequent in primary and secondary health care. They are often accompanied by depression and/or anxiety, and cause functional impairment. The Patient Health Question-naire Somatic Symptom Scale (PHQ-15) was developed to measure somatic symptom distress based on the frequency and bothersomeness of non-specific somatic symptoms. The study aimed to (1) evaluate the Hungarian version of the PHQ-15 from a psychometric point of view; (2) replicate the bifactor structure and associations with negative affect described in the literature; and (3) provide the Hungari…
Analysing the Impact of the Glass Ceiling in a Managerial Career: The Case of Spain
2021
The need to break down the barriers facing women in the labour market arouses great interest for reasons of social and sustainability justice. This study breaks new ground on the topic of the “glass ceiling” by assessing the evolution of gender inequality in the proportion of individuals reaching high managerial positions. The application of the csQCA method to a survey of two cohorts of Spanish graduates in management sharing the same starting conditions reveals two factors: job variety and additional education, as conditions that are usually present in a successful managerial career. Our findings confirm the prevalence of the gender gap with little progress in recent years. Women find it …
Operational Experience and Performance of the Belle II Pixel Detector
2021
Proceedings of the 29th International Workshop on Vertex Detectors (VERTEX2020), Tsukuba, Japan (Online); Journal of the Physical Society of Japan 34, 010002 (2021). doi:10.7566/JPSCP.34.010002
Physical and mechanical properties of sustainable hydraulic mortar based on marble slurry with waste glass
2021
This paper aims to propose and characterize a sustainable hydraulic mortar entirely obtained by the reuse of waste materials, with marble slurry coming from quarries in the north-western Sicily and glass powder coming from a waste collection plant in Marsala (Province of Trapani). The first was used as raw material to produce the mortar binder by a kilning and slaking process, while the second was used as a pozzolanic additive. The chemical and morphological characterization of the marble slurry was done by XRD, FTIR, STA and SEM analyses. Glass powder was analyzed through particle size distribution measurements, XRD and standard pozzolanic tests. Hydraulic mortars constituted by slaked lim…
Metabolic Aspects of Migraine: Association With Obesity and Diabetes Mellitus
2021
Migraine is a disabling neurovascular disorder, characterized by moderate to severe unilateral headaches, nausea, photophobia, and/or phonophobia, with a higher prevalence in women than in men, which can drastically affect the quality of life of migraine patients. In addition, this chronic disorder is related with metabolic comorbidities associated with the patient's lifestyle, including obesity and diabetes mellitus (DM). Beyond the personal and socioeconomic impact caused by migraine, obesity and DM, it has been suggested that these metabolic disorders seem to be related to migraine since: (i) they are a risk factor for developing cardiovascular disorders or chronic diseases; (ii) they ca…
Evidence against the wobbling nature of low-spin bands in 135Pr
2021
International audience; The electromagnetic character of the ΔI=1 transitions connecting the 1- to 0-phonon and the 2- to 1-phonon wobbling bands should be dominated by an E2 component, due to the collective motion of the entire nuclear charge. In the present work it is shown, based on combined angular correlation and linear polarization measurements, that the mixing ratios of all analyzed connecting transitions between low-lying bands in 135Pr interpreted as 0-, 1-, and 2-phonon wobbling bands, have absolute values smaller than one. This indicates predominant M1 magnetic character, which is incompatible with the proposed wobbling nature. All experimental observables are instead in good agr…
Molecular phylogenetics of the Dissochaeta alliance (Melastomataceae): Redefining tribe Dissochaeteae
2021
Self-selected running gait modifications reduce acute impact loading, awkwardness, and effort
2021
Impact loading has been associated with running-related injuries, and gait retraining has been suggested as a means of reducing impact loading and lowering the risk of injury. However, gait retraining can lead to increased perceived awkwardness and effort. The influence of specifically trained and self-selected running gait modifications on acute impact loading, perceived awkwardness and effort is currently unclear. Sixteen habitual rearfoot/midfoot runners performed forefoot strike pattern, increased step rate, anterior trunk lean and self-selected running gait modifications on an instrumented treadmill based on real-time biofeedback. Impact loading, perceived awkwardness and effort scores…
Caspase 9 and Caspase 3 Immunohistochemical Pattern in Skeletal and Cardiac Muscles at Different Times after Death: An Experimental Study on PMI Esti…
2021
(1) Background: The estimation of the post mortem interval (PMI) is a challenge for forensic pathologists because data emerging from methods commonly applied are not always conclusive, since several conditions exist that may affect the reliability of these parameters. Thus, new approaches have been proposed to overcome such a limit. In recent years, several studies have been performed on proteins analyzing their expression/degradation patterns in relation to the progressing of the post mortem interval. (2) Methods: The immunoreactivity patterns of two apoptosis mediators—Caspase 9 and Caspase 3—have been tested in order to evaluate their potential role as markers of the post mortem interval…
Signatures of primordial black hole dark matter at DUNE and THEIA
2021
Primordial black holes (PBHs) are a potential dark matter candidate whose masses can span over many orders of magnitude. If they have masses in the $10^{15}-10^{17}$ g range, they can emit sizeable fluxes of MeV neutrinos through evaporation via Hawking radiation. We explore the possibility of detecting light (non-)rotating PBHs with future neutrino experiments. We focus on two next generation facilities: the Deep Underground Neutrino Experiment (DUNE) and THEIA. We simulate the expected event spectra at both experiments assuming different PBH mass distributions and spins, and we extract the expected 95% C.L. sensitivities to these scenarios. Our analysis shows that future neutrino experime…
Energy and Personality: A Bridge between Physics and Psychology
2021
[EN] The objective of this paper is to present a mathematical formalism that states a bridge between physics and psychology, concretely between analytical dynamics and personality theory, in order to open new insights in this theory. In this formalism, energy plays a central role. First, the short-term personality dynamics can be measured by the General Factor of Personality (GFP) response to an arbitrary stimulus. This GFP dynamical response is modeled by a stimulus¿response model: an integro-differential equation. The bridge between physics and psychology appears when the stimulus¿response model can be formulated as a linear second order differential equation and, subsequently, reformulat…
Identifying Biomarkers for Biological Age: Geroscience and the ICFSR Task Force
2021
The International Conference on Frailty and Sarcopenia Research Task Force met in March 2020, in the shadow of the COVID-19 pandemic, to discuss strategies for advancing the interdisciplinary field of geroscience. Geroscience explores biological mechanisms of aging as targets for intervention that may delay the physiological consequences of aging, maintain function, and prevent frailty and disability. Priorities for clinical practice and research include identifying and validating a range of biomarkers of the hallmarks of aging. Potential biomarkers discussed included markers of mitochondrial dysfunction, proteostasis, stem cell dysfunction, nutrient sensing, genomic instability, telomere d…
Clinical‑dermoscopic similarities between atypical nevi and early stage melanoma
2021
Atypical (Clark) nevi are benign tumors that may be considered precursors of melanoma. Many studies acknowledge a linear progression from typical to atypical nevi that eventually transform into melanoma. It is often challenging to differentiate a Clark nevus from melanoma, especially in its early stages, due to their clinical, dermoscopic, and histological resemblance. Dermoscopy is a powerful tool in early melanoma diagnosis, but it is a subjective method of examination. Therefore, the use of dermoscopic algorithms and checklists can overcome this issue. In the case of a difficult diagnosis, since both dermoscopy and histopathological exam are subjective methods of examination, modern mole…
Cluster development and regional industrial restructuring: agency and asset modification
2021
The paper presents a novel theoretical framework to analyse the emergence and growth of industrial clusters. The framework focuses on the role of change agency for the modification of assets that i...
Modulating Long Term Memory at Late-Encoding Phase: An rTMS Study
2021
Despite a huge effort of the scientific community, the functioning of Long-Term Memory (LTM) processes is still debated and far from being elucidated. Functional and neurophysiological data point to an involvement of Dorsolateral Prefrontal Cortex (DLPFC) in both encoding and retrieval phases. However, the recently proposed Explicit/Implicit Memory Encoding and Retrieval (EIMER) model proposes that LTM at the encoding phase consists of anatomically and chronologically different sub-phases. On this basis, we aimed to investigate the role of right DLPFC during a late-encoding phase by means of low-frequency rTMS. Thirty right-handed healthy subjects were divided into three experimental groups…