showing 36 of ~574560 from 574555 documents
Taking into Account Patient Preferences: A Consensus Study on the Assessment of Psychological Dimensions Within Patient Preference Studies
2021
Selena Russo,1,2,* Dario Monzani,3,4,* Cathy Anne Pinto,5 Laura Vergani,3,4 Giulia Marton,3,4 Marie Falahee,6 Gwenda Simons,6 Chiara Whichello,7 Ulrik Kihlbom,8,* Gabriella Pravettoni3,4,* 1Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy; 2Discipline of Paediatrics, School of Women’s and Children’s Health, The University of New South Wales, Kensington, NSW, Australia; 3Applied Research Division for Cognitive and Psychological Science, IEO, European Institute of Oncology IRCCS, Milan, Italy; 4Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy; 5Department of Pharmacoepidemiology, Merck & Co., Inc., Kenilwor…
Pratiques d'enseignement à l'université
2021
International audience
: Les dispositifs sociotechniques liés à l’innovation comme lieux d’actualisations et de mise en circulation de discours organisationnels, pratiques …
2021
International audience; L’implantation d’une nouvelle technologie, d’un nouveau dispositif porteur d’un savoir, de valeurs, de cultures et ayant même une présence physique dans ces entreprises, implique des enjeux économiques et des enjeux de réorganisation. Ces enjeux de dénomination et ces stratégies de présentation de soi viennent mettre en avant, entre autres, des luttes de quête de légitimité auprès des acteurs intégrés et reconnus dans l’espace professionnel journalistique. Ces luttes sont aussi structurantes dans la reconnaissance des capitaux mis en avant au sein du champ journalistique (Sedel, 2021). Les dirigeants qui composent les instances de directions se déplacent aux frontièr…
Rapport à l'école et au marché du travail des élèves de CAP
2021
International audience
Reactivity of the Superheavy Element 115, Mc, and Its Lighter Homologue, Bi, with Respect to Gold and Hydroxylated Quartz Surfaces from Periodic Rela…
2021
Adsorption energies (Eads) of the superheavy element (SHE) Mc, its lighter homologue (Bi), as well as of another superheavy element Nh and some lighter homologues of SHEs on gold and hydroxylated quartz surfaces are predicted via periodic relativistic density functional theory calculations. The aim of this study is to support "one-atom-at-a-time" gas-phase chromatography experiments that are examining the reactivity and volatility of Mc. The obtained Eads values of the Bi and Mc atoms on the Au(111) surface are >200 kJ/mol. On the hydroxylated quartz surface, Mc should adsorb with a minimal energy of 58 kJ/mol. On both types of surfaces, Eads(Mc) should be ∼100 kJ/mol smaller than Eads(Bi) …
La question du paysage dans "White Writing" de J.M. Coetzee
2021
National audience
Transient FTIR spectroscopy after one- and two-colour excitation on a highly luminescent chromium(III) complex.
2021
The development of photoactive transition metal complexes with Earth-abundant metals is a rapidly growing research field, where a deeper understanding of the underlying photophysical processes is of great importance. A multitude of potential applications in the fields of photosensitizing, optical sensing, photoluminescence and photoredox catalysis motivates demanding spectroscopic studies. We applied a series of high-level spectroscopic methods on the previously reported highly luminescent chromium(iii) complex [Cr(ddpd)2](BF4)3 (ddpd = N,N'-dimethyl-N,N'-dipyridine-2-ylpyridine-2,6-diamine) possessing two near-IR emissive doublet states with microsecond lifetimes. Luminescence measurements…
Forward genetics inWolbachia: Regulation ofWolbachiaproliferation by the amplification and deletion of an addictive genomic island
2021
Copyright: © 2021 Duarte et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Microvascular blood flow changes of the abductor pollicis brevis muscle during sustained static exercise
2021
A practical assessment of the general health and microvascular function of the palm muscle, abductor pollicis brevis (APB), is important for the diagnosis of different conditions. In this study, we have developed a protocol and a probe to study microvascular blood flow using near-infrared diffuse correlation spectroscopy (DCS) in APB during and after thumb abduction at 55% of maximum voluntary contraction (MVC). Near-infrared time resolved spectroscopy (TRS) was also used to characterize the baseline optical and hemodynamic properties. Thirteen (n=13) subjects were enrolled and subdivided in low MVC (N=6, MVC<2.3 kg) and high MVC (N=7, MVC≥2.3 kg) groups. After ruling out significant cha…
Retour sur les enjeux de la recherche en formation
2021
International audience
Common Core in Danger? Personalized Information and the Fragmentation of the Public Agenda
2021
The diversification of information sources has reignited the controversy on media-induced fragmentation endangering social integration. The media's capability to set the public agenda and create issues as a common core is a pivotal part of the public sphere and contributes fundamentally to society's cohesion. Algorithm-driven sources like social media that personalize content to the preferences of individuals and their social networks are considered agents of fragmentation of the public sphere. Politically extreme individuals relying on them may be particularly vulnerable to losing touch with society's common core. We employ an innovative operationalization of fragmentation on the individu…
Towards a Joint International Database: Alignment of SSR Marker Data for European Collections of Cherry Germplasm
2021
International audience; The objective of our study was the alignment of microsatellite or simple sequence repeat (SSR) marker data across germplasm collections of cherry within Europe. Through the European Cooperative program for Plant Genetic Resources ECPGR, a number of European germplasm collections had previously been analysed using standard sets of SSR loci. However, until now these datasets remained unaligned. We used a combination of standard reference genotypes and ad-hoc selections to compile a central dataset representing as many alleles as possible from national datasets produced in France, Great Britain, Germany, Italy, Sweden and Switzerland. Through the comparison of alleles c…
Démissions des enseignants stagiaires
2021
International audience
Constraints on Cosmic Strings Using Data from the Third Advanced LIGO–Virgo Observing Run
2021
We search for gravitational-wave signals produced by cosmic strings in the Advanced LIGO and Virgo full O3 data set. Search results are presented for gravitational waves produced by cosmic string loop features such as cusps, kinks and, for the first time, kink-kink collisions.cA template-based search for short-duration transient signals does not yield a detection. We also use the stochastic gravitational-wave background energy density upper limits derived from the O3 data to constrain the cosmic string tension, $G\mu$, as a function of the number of kinks, or the number of cusps, for two cosmic string loop distribution models.cAdditionally, we develop and test a third model which interpolat…
Comment la dégradation de la vie étudiante a-t-elle affecté les manières d’étudier durant la pandémie ?
2021
International audience; Souvent considérée comme privilégiée par rapport aux autres jeunes, la population étudiante apparaît de plus en plus hétérogène en termes de ressources comme de conditions de vie. Les premières enquêtes sur les conséquences de la pandémie ont pointé cette dégradation des conditions de vie et d’études pour une partie de la population étudiante. Cette proposition de communication se base sur l’exploitation d’une enquête sur la vie étudiante durant le premier confinement. Elle s’interroge notamment sur les effets de la dégradation des conditions de vie des étudiants sur leurs manières d’étudier. Le questionnaire a été construit et diffusé en avril 2020. 3 396 personnes …
«Señores de la tierra». El «Camino Valenciano» y la Guerra de los Treinta Años
2021
La guerra de Mantua-Monferrato (1628-1631), el rompimiento con Francia (1635) y, sobre todo, la rebelión de Cataluña (1640) situaron progresivamente al mediterráneo reino de Valencia en el centro de la logística de la monarquía hispánica durante la Guerra de los Treinta Años. Mientras otros corredores militares colapsaban, el «camino valenciano» fue crucial para el desplazamiento de las fuerzas de Felipe IV y la integración del reino en la Unión de Armas, cuyo máximo exponente administrativo fue la creación de una Junta de guerra en la frontera valenciana. Interpretar las consecuencias militares y socioeconómicas es la finalidad de este trabajo.
Immune Checkpoint Inhibitors and Cardiotoxicity: An Analysis of Spontaneous Reports in Eudravigilance
2021
Introduction Immune checkpoint inhibitors (ICIs) are widely used in the treatment of many cancers as they improve clinical outcomes. However, ICIs have also been associated with the development of immune-related adverse drug reactions (ADRs). Among immune-related ADRs, cardiac immune-related ADRs are rare, but also associated with high mortality rates. Objective The objective of this study was to evaluate the occurrence of cardiac ADRs reported with ICIs in the European spontaneous reporting system. Methods We retrieved individual case safety reports on ICI-induced cardiac ADRs from the website of suspected ADR (www.adrreports.eu) of the European pharmacovigilance database (Eudravigilance).…
Exploring learning analytics on YouTube: a tool to support students interactions analysis
2021
YouTube is a free online video-sharing platform that is often used by students for their learning activities. The interactions of the students when using the platform to shape new concepts, are worth to be investigated to better understand and to optimize the learning opportunities that take place in this platform. In this paper, we investigate which types of data are relevant to analyse the interactions of students with content on YouTube, and we introduce a new tool that emulates students’ interactions with the platform in order to provide data to be used in supporting Learning Analytics approaches. Our preliminary study inspects the tool effectiveness in data collection and analyses the …
construcción de una europa más igualitaria desde la protección de las víctimas de violencia de género
2021
El propósito de este artículo es analizar las aristas de la Directiva sobre la Orden Europea de Protección cuando se trata de proteger a las víctimas de violencia de género. El inexistente concepto de víctima de violencia de género dificulta sobremanera el adecuado uso del instrumento y nos muestra cuánta Europa queda por construir. Al final del artículo proponemos la creación de una medida cautelar civil para acercarnos al resto de ordenamientos jurídicos de nuestro entorno y facilitar el reconocimiento mutuo.
Trends in Incidence and Transmission Patterns of COVID-19 in Valencia, Spain
2021
Importance Limited information on the transmission and dynamics of SARS-CoV-2 at the city scale is available. Objective To describe the local spread of SARS-CoV-2 in Valencia, Spain. Design, Setting, and Participants This single-center epidemiological cohort study of patients with SARS-CoV-2 was performed at University General Hospital in Valencia (population in the hospital catchment area, 364 000), a tertiary hospital. The study included all consecutive patients with COVID-19 isolated at home from the start of the COVID-19 pandemic on February 19 until August 31, 2020. Exposures Cases of SARS-CoV-2 infection confirmed by the presence of IgM antibodies or a positive polymerase chain reacti…
The Use of Computer Navigation in Total Hip Arthroplasty Is Associated with a Reduced Rate of Revision for Dislocation
2021
BACKGROUND: The use of computer navigation has been shown to produce more accurate cup positioning when compared with non-navigated total hip arthroplasty (THA), but so far there is only limited evidence to show its effect on clinical outcomes. The present study analyzed data from the Australian Orthopaedic Association National Joint Replacement Registry to assess the impact of computer navigation on the rates of all-cause revision and revision for dislocation following THA. METHODS: Data for all non-navigated and navigated primary THAs performed for osteoarthritis in Australia from January 1, 2009, to December 31, 2019, were examined to assess the rate of revision. We analyzed the effects …
Predictors of scaffold failure and impact of optimized scaffold implantation technique on outcome: Results from the German-Austrian ABSORB RegIstRy.
2021
Aims We aimed to investigate predictors of scaffold failure and the potential impact of an optimized scaffold implantation technique by means of a learning curve on long-term clinical outcome after bioresorbable scaffold (BRS) implantation and to evaluate predictors of scaffold failure. Methods and results A total of 3326 patients were included in this prospective, observational, multi-center study (ClinicalTrials.gov NCT02066623) of consecutive patients undergoing BRS implantation between November 2013 and January 2016. The 3144 patients completed follow-up after 24 months, 3265 patients were eligible for time-to-event-analysis. Clinical endpoints were major adverse cardiac events-a compos…
The colocalizations of pulp neural stem cells markers with dentin matrix protein-1, dentin sialoprotein and dentin phosphoprotein in human denticle (…
2021
Abstract Background The primary dentin, secondary dentin, and reactive tertiary dentin are formed by terminal differentiated odontoblasts, whereas atubular reparative tertiary dentin is formed by odontoblast-like cells. Odontoblast-like cells differentiate from pulpal stem cells, which express the neural stem cell markers nestin, S100β, Sox10, and P0. The denticle (pulp stone) is an unique mineralized extracellular matrix that frequently occurs in association with the neurovascular structures in the dental pulp. However, to date, the cellular origin of denticles in human dental pulp is unclear. In addition, the non-collagenous extracellular dentin matrix proteins dentin matrix protein 1 (DM…
The welfare of immigrants: Resilience and sense of community
2021
The accessibility to national health services by immigrants residing in our country has produced a widespread improve- ment of health indicators and health prevention for the entire population. The main goal of this study is to investigate the welfare conditions of immigrants, alongside two fundamental sources of psychological resources. In particular, the role of resilience and sense of community as protective factors against the risk of developing negative welfare outcomes, including life satisfaction and the perception of general health (physical and mental), were considered as indicators. The following self- report questionnaires were sent to a sample of 354 immi- grants, stratified by …
Women in Aeschylean scene: a linguistic characterization
2021
Este trabalho examina os dispositivos linguísticos por meio dos quais Ésquilo conseguiu apresentar as personagens femininas da Oresteia. A análise é feita após um levantamento das seções recitativas de três tragédias; características fonéticas, morfológicas e sintáticas foram estudadas e comparadas com a linguagem dos personagens masculinos. Os resultados desta pesquisa se ajustam a outras tentativas precedentes de mostrar como a sociolinguística pode explicar o retrato formal dos personagens trágicos e cômicos. This paper examines the linguistic devices by means of which Aeschylus achieved the presentation of the female characters of the Oresteia. The analysis is made after a survey of the…
Panintestinal capsule endoscopy in patients with celiac disease
2021
INTRODUCTION Capsule endoscopy has proven its utility in diagnosing villous atrophy and lymphoma in patients with celiac disease. Recently, a novel capsule endoscopy system was introduced which enables the examination of the small and large bowel. So far, it has not been evaluated in patients with celiac disease. OBJECTIVE The primary objective of this study was to evaluate the novel panintestinal capsule endoscopy system in patients with celiac disease. METHODS Eleven patients with histologically proven celiac disease (Marsh 0-IV), who underwent a panintestinal capsule endoscopy between March 2018 and April 2019 at our institution, were included in this retrospective single-center study. A…
‘Whose were those feelings?’ : Affect and likenessing in Halat hisar live action role-playing game
2021
Halat hisar was a live action role-playing game (larp) organized in Finland in 2016. Halat hisar’s ambition as a larp was to mirror the current situation in Palestine. In larps, participants take on different roles and improvise without the presence of an audience. Larps offer a place where emotions and affectivities are transmitted through the embodiment of characters. Larps offer forms of likenessing, which create new affective states for the players. We conclude that larps can be powerful tools for portraying political alternatives of actual events, and they can serve a role in raising awareness. Larps offer a productive context for studying subjectivities where the focus is on affectiv…
Peer interaction and pioneering organizational form adoption : A tale of the first two for-profit stock exchanges
2021
Building on a historical case study on the first two stock exchanges to adopt the now globally dominant for-profit organizational form, the Stockholm Stock Exchange in 1993 and the Helsinki Stock Exchange in 1995, we argue that interaction among socially proximate peers contributes to pioneering organizational form adoption within an industry, particularly when such forms are introduced by established organizations. Peer interaction can induce a search for technically efficient organizational forms through the sharing of collective experiences, the establishment of collective assumptions, and a joint search for solutions. Together, these factors contribute to the legitimization of novel or…
Peripheral CB1 receptor blockade acts as a memory enhancer through an adrenergic-dependent mechanism
2021
Peripheral inputs to the brain continuously shape its function and can influence the formation of non-emotional memory, but the underlying mechanisms have not been fully understood. Cannabinoid type-1 receptors (CB1R), widely distributed in the organism, is a well-recognized player in memory performance, and its systemic modulation significantly influences memory function. By assessing non-emotional memory in mice, we have now found a relevant role of peripheral CB1R in the formation of persistent memory. Indeed, peripherally restricted CB1R antagonism by using AM6545 showed a mnemonic effect that was occluded in adrenalectomized mice, after peripheral adrenergic blockade, or when vagus ner…
Validez de instrumento para medir la competencia territorial. Matriz READI para la autoevaluación de territorios competentes
2021
El artículo presenta el diseño metodológico seguido para el análisis de la validez y fiabilidad de una matriz cuya finalidad es la de permitir a los territorios autoevaluar su grado de competencia potencial para la consecución de objetivos ligados al desarrollo local. Se ha seguido un diseño de estudio descriptivo de construcción de conceptos, dimensiones e indicadores y de verificación de escalas multidimensionales a través de análisis factorial y validez de constructo. El análisis cuantitativo realizado combinado con aportaciones cualitativas de personas expertas, concluye que la matriz es un instrumento válido y confiable para su cometido.
Intelligence artificielle et problèmes de gouvernance dans les pays en développement
2021
Artificial intelligence (AI) is a strategic pillar for the future of humanity. In this perspective, this article examines the advantages and potentials of its use in developing countries, particularly in the governance of those members of UEMOA. Thus, it should be emphasized that AI could significantly improve the governance of WAEMU countries by limiting intermediation in collection or payment systems and thus contribute to better transparency of the systems. It also makes up for the lack of qualified personnel, especially doctors in the most remote areas, it also strengthens security through its ability to enforce the law in the establishment of means of identification and control, in par…
Adapting to High Temperatures: Effect of Farm Practices and Their Adoption Duration on Total Value of Crop Production in Uganda
2021
In this article, we use spatially granular climate data merged with four waves of household survey data in Uganda to examine empirically the relationships among high temperatures, total value of crop production, and the adoption and adoption duration of two sustainable agricultural practices (organic fertilizer adoption and maize–legume intercropping). We do this using a fixed-effect model with instrumental variables to address potential endogeneity issues. Our findings indicate that the adoption of these practices has a positive effect on the total value of crop production, and such effect increases monotonically as temperatures increase from long-term averages. Moreover, the number of yea…
Phytochemical Profile and Antioxidant Activity of the Aerial Part Extracts from Matthiola incana subsp. rupestris and subsp . pulchella ( Brassicacea…
2021
As part of a project aimed at investigating the Matthiola taxa endemic to Sicily (Italy), this study focused on Matthiola incana, an edible species used in the traditional medicine of various countries. Herein, the characterization of phenolic and volatile compounds, the antioxidant capacity in vitro (1,1-diphenyl-2-picrylhydrazil (DPPH), reducing power and Fe2+ chelating activity assays) and the toxicity test (Artemia salina lethality bioassay) of the hydroalcoholic extracts from the aerial parts of M. incana subsp. rupestris from Mt. Pellegrino (Palermo) and Mt. Erice (Trapani), and of M. incana subsp. pulchella are reported. The results are compared with those previously shown for M. inc…
Exposure assessment of Spanish lactating mothers to acrylamide via human biomonitoring.
2021
Abstract Acrylamide (AA) is an organic compound classified as “Probably carcinogenic to humans” (Group 2 A) that can be found principally in processed carbohydrate-rich foods and tobacco smoke. In humans, after exposure, AA is rapidly metabolized and excreted in urine, predominantly as N-acetyl-S-(2-carbamoylethyl)-l-cysteine (AAMA), N-acetyl-S-(2-carbamoyl-2-hydroxyethyl)-l-cysteine (GAMA3) and N-Acetyl-3-[(3-amino-3-oxopropyl)sulfinyl]-L-alanine (AAMA-Sul), which can be used as short-term biomarkers of exposure to AA. In this study, the presence of AA metabolites in urine samples of lactating mothers living in Spain (n = 114) was analyzed by “dilute and shoot” and liquid chromatography co…
Maaseutuväestön matkat muualle
2021
Analysoin artikkelissani maaseutuväestön liikkuvuutta 1840-luvun aikana kahdessa maaseutupitäjässä: Hämäläisessä Hollolassa ja karjalaisessa Jaakkimassa. Lähdeaineistona toimivat niin kutsutut annettujen todistusten diaarit, joihin papit kirjasivat muistiin heiltä pyydetyt erilaiset todistukset. Lähdeaineisto antaa kuitenkin vain tilaisuuden hahmottaa liikkuvuuden rajoja, sillä kirkon hallintoarkistoon kuuluvia annettujen todistusten diaareja ei ole pidetty tai säilynyt kovinkaan monesta seurakunnasta. Artikkelissani kysyn, ketkä yleensä lähtivät liikkeelle oman kotipitäjän ulkopuolelle, miksi ja millaisin todistuksin? Samalla selvitän liikkuvuuden kontrollointiin liittyviä yleisiä seikkoja…
Fracture toughness of different monolithic zirconia upon post-sintering processes
2021
Background Surface treatments are expected to be a reason for alteration in fracture resistance of zirconia. This study evaluated the effect of post-sintering processes on the fracture toughness of different types of monolithic zirconia. Material and Methods Classical- (Cz) and high-translucent (Hz) monolithic zirconia discs (1.2 mm thickness, 14 mm in Ø) were prepared, and randomly divided for surface treatments with 1) as-glazed (AG); 2) finished and polished (FP); 3) finished, polished, and overglazed (FPOG); and 4) finished, polished, and heat-treated (FPHT) technique (n=15/group). Fracture toughness (KIC) was determined with indentation fracture toughness method at load 1 kg for AG, FP…