showing 36 of ~574560 from 574555 documents
Dialogic Learning Environments That Enhance Instrumental Learning and Inclusion of Students With Special Needs in Secondary Education
2021
Across Europe, the enrolment of students with special educational needs in regular classrooms is increasing, although it does not always mean access to high quality educational experience. In this context, inclusive education has been enhanced in most educational systems, but its successful implementation is still limited and has become a challenge in most countries, and specially in secondary education, when segregation due to learning achievement is more frequent. Educational practices that take into account the potential of promoting learning interactions within heterogeneous groups of students have already demonstrated contributing to educational inclusion of students with special needs…
Accounting for species interactions is necessary for predicting how arctic arthropod communities respond to climate change
2021
Species interactions are known to structure ecological communities. Still, the influence of climate change on biodiversity has primarily been evaluated by correlating individual species distributions with local climatic descriptors, then extrapolating into future climate scenarios. We ask whether predictions on arctic arthropod response to climate change can be improved by accounting for species interactions. For this, we use a 14-year-long, weekly time series from Greenland, resolved to the species level by mitogenome mapping. During the study period, temperature increased by 2 degrees C and arthropod species richness halved. We show that with abiotic variables alone, we are essentially un…
Does the internet increase the job finding rate? Evidence from a period of expansion in internet use
2021
Abstract We examine the impact of household access to the internet on job finding rates in Germany during a period (2006–2009) in which the share of households with a broadband connection increased by 31 percentage points, and job-seekers increased their use of the internet as a search tool. During this period, household access to broadband internet was almost completely dependent on the availability of a particular technology (DSL). We therefore exploit the variation in DSL availability across municipalities as an instrument for household access to the internet. OLS estimates which control for differences in individual and local area characteristics suggest a job finding advantage of about…
WILLINGNESS TO RECEIVE COVID-19 VACCINATION IN COSTUMERS ACCESSING COMMUNITY PHARMACIES IN THE PROVINCE OF PALERMO, ITALY
2021
In Italy, vaccination against COVID-19 began on December 27, 2020. To date, 13,713,224 people in Italy are fully vaccinated, which accounts for 25.3 % of the general population, and 44.8% received at least one vaccination dose. The present study aim to investigate willingness to receive COVID-19 vaccination in costumers accessing a sample of community pharmacies in the Province of Palermo, Italy. A self-administered and anonymous questionnaire was carried out among costumers older than 18 years old between December 2020 and March 2021. Three hundred and sixty-three subjects were enrolled in the study, 259 (71.3%) expressed their willingness to receive COVID-19 vaccination. The main determin…
HGG-03. THE GLYCOSPHINGOLIPIDS METABOLISM IS A NOVEL TARGET IN H3K27M-MUTANT DIFFUSE MIDLINE GLIOMA
2021
Abstract H3K27M-mutant diffuse midline glioma (H3K27M-mutant DMG) is a rare malignant brain tumour entity in children and adults with a median overall survival of around 12 months. Genomic and proteomic analysis may help to identify new target structures, however not all relevant targets are covered by these analyses. Glycosphingolipids and particularly gangliosides play a major role in brain development and have been involved in the pathology of brain tumours. The conversion of ceramide to glucosylceramide via glucosylceramide synthase (GCS) is one of the first steps in the synthesis of glycosphingolipids. Therefore, targeting GCS will inhibit their synthesis. Here we analysed the glycosph…
Presentazione dell’edizione italiana di storia della Sicilia da Odisseo ai giorni nostri di Jean-Yves Frétigné
2021
Published for the first time in 2009, for the Fayard types, and re-edited in 2018 in a "pocket" format, this History of Sicily by Jean-Yves Frétigné, with the subtitle from Odysseus to the present day, presented to the French public as an easy consultation, a "Compagnon de voyage" destined to have an excellent editorial success with over 8,000 copies sold.The Italian translation presented here does not have the presumption of concurring with the monumental works of the history of Sicily which constitute an essential reference by the same Author, as the rich bibliography in the appendix to the volume clearly testifies. Rather, it intends to offer, in just over 400 pages, the “external” look …
The influence of the Covid-19 pandemic on Czech-Polish cross-border cooperation: From debordering to re-bordering?
2021
Abstract The COVID-19 pandemic brought many changes to social behaviours in Europe. One of its major consequences was the temporary closure of borders, which was introduced as a measure to prevent the uncontrolled pandemic spreading and involved internal Schengen borders. This has had a major impact in the way in which cross-border cooperation has been conducted in Europe, including the Czech-Polish borderland, as it dramatically restrained all flows across borders. In this paper, we evaluate the impact of the pandemic on five roles of cross-border cooperation: 1) as a multi-level governance form; 2) as a regional development tool; 3) as a para-diplomacy form; 4) as a post-conflict reconcil…
Protectionism through legislative layering: Implications for auditors and investors
2021
AbstractProtectionism is on the rise. Although it tends to be associated with tariffs on imports, governments are increasingly applying other mechanisms to influence international business. Import substitution initiatives have been used to replace purchases from foreign producers with local alternatives. Russia implemented import substitution through legislative layering where layers of regulation created requirements targeting different industries and companies. Following sanctions imposed in 2014 on Russia, the government responded with additional import substitution efforts. We are interested in effects of such measures on the Big 4, global professional service firms, and the choice of a…
Regulating blockchain for sustainability? The critical relationship between digital innovation, regulation, and electricity governance
2021
Abstract Blockchain technology has found several innovative applications in the electricity industry. However, its potential has still to be discovered. This is partly due to the role that regulation plays in electricity markets. To be introduced, experimented with, and eventually adopted on a commercial scale, blockchain-supported innovations need to fit the existing regulatory framework or the rules to be reshaped or updated. We focus on energy regulators' possible responses to the blockchain-enhanced market operations (both from the incumbents and potential newcomers), suggesting a monitoring mechanism that can support innovation.
Renewable Energy Sources in the Baltic States and New Business Approach of the Sector
2021
Renewable energy sources (RES) are efficient in meeting the demand for clean and affordable energy. The need for RES is undeniable and has many advantages but there are also some challenges that need to be taken into consideration and adapted to the energy system. One of the challenges is RES volatility and its impact on electricity prices and power system operation. Europe is trending to power system decentralisation through the involvement of local authorities, active consumers and citizens in the system operation. This article provides main information about the energy sector of Latvia and RES in the Baltic countries. It proposes a methodology for the complex analysis of correlation and …
Prediction of cardiovascular events with traditional risk equations and total plaque area of carotid atherosclerosis
2021
Abstract A large number of cardiovascular events occur in seemingly healthy individuals. Atherosclerosis imaging can improve the outcome and treatment regime of such subjects. We aim to assess the predictive value of atherosclerosis imaging beyond traditional risk calculators in subjects aged 40–65 years. We compared PROCAM, SCORE and FRAM with carotid ultrasound (total plaque area, TPA) and arterial age (AA) was calculated in subjects without known cardiovascular diseases. Follow-up was obtained by phone or mail. In 2842 subjects (age 50 ± 8, 38% women) 154 (5.4%) cardiovascular events occurred (ASCVD: 41 myocardial infarctions, 16 strokes or TIA, 21 CABG, 41 PTCA, 35 coronary artery disea…
Survival Rate and Prosthetic and Sinus Complications of Zygomatic Dental Implants for the Rehabilitation of the Atrophic Edentulous Maxilla: A System…
2021
Simple Summary Zygomatic dental implants have been proposed as an alternative to atrophic total edentulous maxillae rehabilitation with the necessity of bone grafting procedures. However, surgical, prosthetic, and maxillary sinus complications have been associated with this surgical procedure. Therefore, it is necessary to produce a systematic review and meta-analysis that provides evidence associated with the prognosis when using zygomatic dental implants as an alternative to atrophic total edentulous maxillae rehabilitation. Abstract The aim of this systematic review and meta-analysis was to analyze and compare the survival rate and prosthetic and sinus complications of zygomatic dental i…
Profiling Dopamine-Induced Oxidized Proteoforms of β-synuclein by Top-Down Mass Spectrometry
2021
The formation of multiple proteoforms by post-translational modifications (PTMs) enables a single protein to acquire distinct functional roles in its biological context. Oxidation of methionine residues (Met) is a common PTM, involved in physiological (e.g., signaling) and pathological (e.g., oxidative stress) states. This PTM typically maps at multiple protein sites, generating a heterogeneous population of proteoforms with specific biophysical and biochemical properties. The identification and quantitation of the variety of oxidized proteoforms originated under a given condition is required to assess the exact molecular nature of the species responsible for the process under investigation…
Analyse des discours autour du Dépistage Néonatal sur Twitter dans le cadre du Projet SeDeN
2021
Data on physical and chemical characterization of wood combustion products derived at cogeneration power plants
2021
The data presented in this article are related to the research paper “Granulation of fly ash and biochar with organic lake sediments – A way to sustainable utilization of waste from bioenergy production” [1] in the context of waste material investigation and possible valorization instead of disposal. This article provides a comprehensive chemical and physical characterization of wood combustion products – fly ashes, bottom ashes, mixed ashes and biochar. Multiple analytical techniques and methodology were exploited to investigate the composition of wood combustion products, among them a loss on ignition, potentiometry, colorimetry, X-ray diffractometry, X-ray fluorescence spectrometry, indu…
Entwicklung der satzinternen Großschreibung kontrastiv
2021
Abstract Während die Entwicklung der satzinternen Großschreibung von Nomina und Nominalisierungen fürs Deutsche gut untersucht ist, stellt sie für viele andere Sprachen, in denen ebenfalls eine (wenn auch kurzlebige) Tendenz zur satzinternen Großschreibung festzustellen ist, ein Forschungsdesiderat dar. In diesem Beitrag stellen wir methodische Überlegungen zur kontrastiven Untersuchung der Entwicklung der satzinternen Großschreibung im Deutschen, Englischen und Niederländischen vor und diskutieren die Ergebnisse erster Pilotstudien. Neben übergreifenden Tendenzen zeigen sich auch deutliche Unterschiede, aus denen sich die Notwendigkeit zu einer differenzierten Betrachtung der einzelsprachl…
Crop Nitrogen Retrieval Methods for Simulated Sentinel-2 Data Using In-Field Spectrometer Data.
2021
Nitrogen (N) is one of the key nutrients supplied in agricultural production worldwide. Over-fertilization can have negative influences on the field and the regional level (e.g., agro-ecosystems). Remote sensing of the plant N of field crops presents a valuable tool for the monitoring of N flows in agro-ecosystems. Available data for validation of satellite-based remote sensing of N is scarce. Therefore, in this study, field spectrometer measurements were used to simulate data of the Sentinel-2 (S2) satellites developed for vegetation monitoring by the ESA. The prediction performance of normalized ratio indices (NRIs), random forest regression (RFR) and Gaussian processes regression (GPR) f…
Prefazione a: IL SOGGIORNO A TROGEN. Racconti e poesie
2021
About the circumstances of Vrettakos' visit in Trogen (Switzerland)
Adolescence, Adulthood and Self-Perceived Halitosis: A Role of Psychological Factors
2021
(1) Background: Halitosis is a frequent condition that affects a large part of the population. It is considered a “social stigma”, as it can determine a number of psychological and relationship consequences that affect people’s lives. The purpose of this review is to examine the role of psychological factors in the condition of self-perceived halitosis in adolescent subjects and adulthood. (2) Type of studies reviewed: We conducted, by the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analyses) guidelines, systematic research of the literature on PubMed and Scholar. The key terms used were halitosis, halitosis self-perception, psychological factors, breath odor and two te…
La linea spezzata. Una ricostruzione critica dell'attuale deficit di coerenza
2021
Siamo nell’era della smemoratezza. Una smemoratezza prodotta dalla sovrabbondanza di informazioni, dalla pratica del multitasking, dalla propensione a demandare la conservazione dei ricordi ai device e ai cloud di cui facciamo uso ogni giorno. La fragilità della memoria ha spezzato la linea che congiungeva passato, presente e futuro, la linea che li attraversava e li rendeva coerenti. Ma lo ha fatto solo nella nostra testa, perché sul piano della realtà gli effetti delle scelte di ieri non smettono di presentarsi all’oggi. L’allargamento degli orizzonti culturali prodotto dalla globalizzazione ha ridotto tutti gli elementi del nostro panorama a dettagli lontani e indistinguibili. Ma lo ha f…
Aspects Regarding the use of Biodegradable Ecological Detergents in the Decontamination of R.B.C.
2021
Abstract Ecological decontamination solutions are widely used in various fields of activity especially in this period when many countries in the world are implementing at macro level the concept of sustainable development. The use of detergents in the process of R.B.C. decontamination led to in-depth analyzes of the absorbent properties of organic products. These products have the ability to partially or completely remove detergents from wastewater resulting from decontamination, thus reducing pollution by environmental factors. The present paper aimed at the comparative analysis of the absorbent properties of a power plant ash and diatomite ore. Also, some experiments were performed on the…
The Odorant-Binding Proteins of the Spider Mite Tetranychus urticae
2021
Spider mites are one of the major agricultural pests, feeding on a large variety of plants. As a contribution to understanding chemical communication in these arthropods, we have characterized a recently discovered class of odorant-binding proteins (OBPs) in Tetranychus urticae. As in other species of Chelicerata, the four OBPs of T. urticae contain six conserved cysteines paired in a pattern (C1–C6, C2–C3, C4–C5) differing from that of insect counterparts (C1–C3, C2–C5, C4–C6). Proteomic analysis uncovered a second family of OBPs, including twelve members that are likely to be unique to T. urticae. A three-dimensional model of TurtOBP1, built on the recent X-ray structure of Varroa destruc…
Isokinetic Profile of Elite Serbian Female Judoists
2021
Elite judo athletes undergo vigorous training to achieve outstanding results. In pursuit of achieving competitive success, the occurrence of injuries amongst judo athletes is not rare. The study aimed to perform a knee flexors and extensors isokinetic torque analysis in elite female judo athletes. Fifty-eight elite female judo athletes of the Serbian national team (21.02 ± 3.11 years
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2021
Abstract Background Clinical management ranges from surveillance or curettage to wide resection for atypical to higher-grade cartilaginous tumours, respectively. Our aim was to investigate the performance of computed tomography (CT) radiomics-based machine learning for classification of atypical cartilaginous tumours and higher-grade chondrosarcomas of long bones. Methods One-hundred-twenty patients with histology-proven lesions were retrospectively included. The training cohort consisted of 84 CT scans from centre 1 (n=55 G1 or atypical cartilaginous tumours; n=29 G2-G4 chondrosarcomas). The external test cohort consisted of the CT component of 36 positron emission tomography-CT scans from…
In the literature: June 2021
2021
Direct Evidence for Viral Antigen Presentation during Latent Cytomegalovirus Infection
2021
Murine models of cytomegalovirus (CMV) infection have revealed an immunological phenomenon known as “memory inflation” (MI). After a peak of a primary CD8+ T-cell response, the pool of epitope-specific cells contracts in parallel to the resolution of productive infection and the establishment of a latent infection, referred to as “latency.” CMV latency is associated with an increase in the number of cells specific for certain viral epitopes over time. The inflationary subset was identified as effector-memory T cells (iTEM) characterized by the cell surface phenotype KLRG1+CD127−CD62L−. As we have shown recently, latent viral genomes are not transcriptionally silent. Rather, viral genes are …
Subclinical Cardiotoxicity: The Emerging Role of Myocardial Work and Other Imaging Techniques.
2021
In recent years, the cancer survival of patients has improved thanks to advances in the pharmacological field. In many guidelines, cardiotoxicity induced by anticancer drugs was defined as a reduction from baseline in the left ventricular ejection fraction (LVEF) assessed by echocardiography. It is known that LVEF is not a sensible parameter in the detection of cardiotoxicity. Therefore, a decrease from baseline in the global longitudinal strain (GLS) or troponins elevation is used to detect subclinical cardiotoxicity. LVEF and GLS as well as the increase in some biomarkers are influenced by loading conditions that are frequent during chemotherapy. Other parameters not influenced by loading…
Potential of Antifungal Proteins (AFPs) to Control Penicillium Postharvest Fruit Decay
2021
Penicillium phytopathogenic species provoke severe postharvest disease and economic losses. Penicillium expansum is the main pome fruit phytopathogen while Penicillium digitatum and Penicillium italicum cause citrus green and blue mold, respectively. Control strategies rely on the use of synthetic fungicides, but the appearance of resistant strains and safety concerns have led to the search for new antifungals. Here, the potential application of different antifungal proteins (AFPs) including the three Penicillium chrysogenum proteins (PAF, PAFB and PAFC), as well as the Neosartorya fischeri NFAP2 protein to control Penicillium decay, has been evaluated. PAFB was the most potent AFP against …
A hybrid virtual–boundary element formulation for heterogeneous materials
2021
Abstract In this work, a hybrid formulation based on the conjoined use of the recently developed Virtual Element Method (VEM) and the Boundary Element Method (BEM) is proposed for the effective computational analysis of multi-region domains, representative of heterogeneous materials. VEM has been recently developed as a generalisation of the Finite Element Method (FEM) and it allows the straightforward employment of elements of general polygonal shape, maintaining a high level of accuracy. For its inherent features, it allows the use of meshes of general topology, including non-convex elements. On the other hand, BEM is an effective technique for the numerical solution of sets of boundary i…
Halévy, fugue d’école und basse donnée
2021
Fuge als satztechnische Ubung – nach Cherubini die ideale Verbindung von strengem Kontrapunkt und freier Komposition – gehorte im 19. Jahrhundert an nahezu allen musikalischen Ausbildungsinstitutionen zum Standardrepertoire, so auch am Conservatoire de Paris: Die Wettbewerbsfugen zum Prix de Rome zeugen vom hohen Niveau der Ausbildung, auch wenn sich die kontrapunktische Ubung immer deutlicher von der kompositorischen Asthetik der Schreibenden entfernte. Anhand von Arbeiten Fromental Halevys wird dieses Niveau aufgezeigt. Dabei kommt sowohl der Schuler Halevy, der seine Wettbewerbsfuge 1819 unter dem Auge Cherubinis verfasste, zu Wort als auch der Lehrer Halevy, dessen Schulerarbeiten einen…
Body Mass Index and Risk for Intubation or Death in SARS-CoV-2 Infection
2021
Precision exercise medicine: predicting unfavourable status and development in the 20-m shuttle run test performance in adolescence with machine lear…
2021
Objectives: To assess the ability to predict individual unfavourable future status and development in the 20m shuttle run test (20MSRT) during adolescence with machine learning (random forest (RF) classifier). Methods: Data from a 2-year observational study (2013‒2015, 12.4±1.3 years, n=633, 50% girls), with 48 baseline characteristics (questionnaires (demographics, physical, psychological, social and lifestyle factors), objective measurements (anthropometrics, fitness characteristics, physical activity, body composition and academic scores)) were used to predict: (Task 1) unfavourable future 20MSRT status (identification of individuals in the lowest 20MSRT tertile after 2 years), and (Task…
The FRAM robotic telescope for atmospheric monitoring at the Pierre Auger Observatory
2021
FRAM (F/Photometric Robotic Atmospheric Monitor) is a robotic telescope operated at the Pierre Auger Observatory in Argentina for the purposes of atmospheric monitoring using stellar photometry. As a passive system which does not produce any light that could interfere with the observations of the fluorescence telescopes of the observatory, it complements the active monitoring systems that use lasers. We discuss the applications of stellar photometry for atmospheric monitoring at optical observatories in general and the particular modes of operation employed by the Auger FRAM. We describe in detail the technical aspects of FRAM, the hardware and software requirements for a successful operati…
Multidimensional Prognostic Index and Mortality in Intermediate Care Facilities: A Retrospective Study.
2021
Multidimensional prognostic index (MPI) is a frailty assessment tool used for stratifying prognosis in older hospitalized people, but data regarding older people admitted to intermediate care facilities (ICFs) are missing. The aim of this study is to evaluate whether MPI can predict mortality in older patients admitted to the ICFs. MPI was calculated using different domains explored by a standard comprehensive geriatric assessment and categorized into tertiles (MPI-1 ≤ 0.20, MPI-2 0.20–0.34, MPI-3 >
Occurrence, mitigation and in vitro cytotoxicity of nivalenol, a type B trichothecene mycotoxin - Updates from the last decade (2010-2020).
2021
Abstract The present review aims to give an overview of the literature of the last decade (2010–2020) concerning the occurrence of the type B trichothecene mycotoxin nivalenol (NIV) and its in vitro toxicity, with the purpose of updating information regarding last researches on this mycotoxin. The most recent studies on the possible methods for preventing Fusarium spp. growth and NIV production are also discussed. Recently, various environmental factors have been shown to influence strongly NIV occurrence. However, Fusarium spp. of the NIV genotype have been found almost worldwide. With regard to NIV cytotoxicity, NIV has been reported to cause a marked decrease in cell proliferation in dif…
The Dual Role of the GABAA Receptor in Peripheral Inflammation and Neuroinflammation: A Study in Hyperammonemic Rats
2021
Cognitive and motor impairment in minimal hepatic encephalopathy (MHE) are mediated by neuroinflammation, which is induced by hyperammonemia and peripheral inflammation. GABAergic neurotransmission in the cerebellum is altered in rats with chronic hyperammonemia. The mechanisms by which hyperammonemia induces neuroinflammation remain unknown. We hypothesized that GABAA receptors can modulate cerebellar neuroinflammation. The GABAA antagonist bicuculline was administrated daily (i.p.) for four weeks in control and hyperammonemic rats. Its effects on peripheral inflammation and on neuroinflammation as well as glutamate and GABA neurotransmission in the cerebellum were assessed. In hyperammone…