showing 36 of ~574560 from 574555 documents
Incorporating TikTok in higher education: Pedagogical perspectives from a corporal expression sport sciences course
2021
Abstract Social media have revolutionised the way humans communicate and socialise. Education is also changing; social media are transforming educational environments, and online or blended learning are increasingly used. The COVID-19 pandemic has further accelerated this change. In this paper, we present an educational innovation where TikTok (a social media that is based on creating and sharing 15–60-s video, which has experienced a significant breakthrough during the COVID-19 pandemic) is used as a pedagogical tool. 65 Spanish sport science students participated in this study. A mixed research method was designed to analyse the effect of TikTok use on students. The SPSS 23.0 and NVivo12 …
Palermo collaborativa
2021
La città di Palermo ha una vocazione multiculturale ed è luogo dell’integrazione e dell’accoglienza. Questa sua caratteristica è confermata dalla partecipazione attiva e propositiva alla redazione della “Carta di Palermo” del 2015 sui temi della mobilità umana internazionale da parte di numerose organizzazioni non governative e realtà associative, accanto alle istituzioni pubbliche. Palermo, come modello positivo di contaminazione culturale e di città collaborativa, lancia la proposta di andare oltre il permesso di soggiorno per approdare al concetto di “cittadinanza di residenza”, riconoscendo il diritto alla mobilità come diritto della persona umana. La migrazione non deve essere consider…
The Effects of N-Acetylcysteine on the Rat Mesocorticolimbic Pathway: Role of mGluR5 Receptors and Interaction with Ethanol
2021
N-acetylcysteine (NAC) is a prodrug that is marketed as a mucolytic agent and used for the treatment of acetaminophen overdose. Over the last few decades, evidence has been gathered that suggests the potential use of NAC as a new pharmacotherapy for alcohol use disorder (AUD), although its mechanism of action is already being debated. In this paper, we set out to assess both the potential involvement of the glutamate metabotropic receptors (mGluR) in the possible dual effect of NAC administered at two different doses and NAC’s effect on ethanol-induced activation. To this aim, 30 or 120 mg/kg of NAC was intraperitoneally administered to rats with the presence or absence of the negative allo…
Efficacy and safety of preoperative with Lugol's iodine solution euthyroid patients with Graves' disease (LIGRADIS Trial): study protocol for a multi…
2021
"Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAM"
Sleep-time physiological recovery is associated with eating habits in distressed working-age Finns with overweight: secondary analysis of a randomise…
2021
Background Association of physiological recovery with nutrition has scarcely been studied. We investigated whether physiological recovery during sleep relates to eating habits, i.e., eating behaviour and diet quality. Methods Cross-sectional baseline analysis of psychologically distressed adults with overweight (N = 252) participating in a lifestyle intervention study in three Finnish cities. Recovery measures were based on sleep-time heart rate variability (HRV) measured for 3 consecutive nights. Measures derived from HRV were 1) RMSSD (Root Mean Square of the Successive Differences) indicating the parasympathetic activation of the autonomic nervous system and 2) Stress Balance (SB) indica…
Role of JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular Mechanisms
2021
Interstitial lung diseases (ILDs) comprise different fibrotic lung disorders characterized by cellular proliferation, interstitial inflammation, and fibrosis. The JAK/STAT molecular pathway is activated under the interaction of a broad number of profibrotic/pro-inflammatory cytokines, such as IL-6, IL-11, and IL-13, among others, which are increased in different ILDs. Similarly, several growth factors over-expressed in ILDs, such as platelet-derived growth factor (PDGF), transforming growth factor β1 (TGF-β1), and fibroblast growth factor (FGF) activate JAK/STAT by canonical or non-canonical pathways, which indicates a predominant role of JAK/STAT in ILDs. Between the different JAK/STAT iso…
false
2021
Funding Information: BSreports personal fees from Allergopharma, during the conduct of the study; grants from National Health Programm, grant, personal fees from Polpharma, ASTRA, personal fees from Mylan, Adamed, patient ombudsman, national Centre for Research and Development, Polish Allergology Society. Funding Information: NGP reports personal fees from Novartis, Nutricia, HAL, MENARINI/FAES FARMA, SANOFI, MYLAN/MEDA, BIOMAY, AstraZeneca, GSK, MSD, ASIT BIOTECH, Boehringer Ingelheim, grants from Gerolymatos International SA, Capricare. Funding Information: CA reports grants from Allergopharma, grants from Idorsia, Swiss National Science Foundation, Christine Kuhne‐Center for Allergy Rese…
Guaranteed and computable error bounds for approximations constructed by an iterative decoupling of the Biot problem
2021
The paper is concerned with guaranteed a posteriori error estimates for a class of evolutionary problems related to poroelastic media governed by the quasi-static linear Biot equations. The system is decoupled by employing the fixed-stress split scheme, which leads to an iteratively solved semi-discrete system. The error bounds are derived by combining a posteriori estimates for contractive mappings with functional type error control for elliptic partial differential equations. The estimates are applicable to any approximation in the admissible functional space and are independent of the discretization method. They are fully computable, do not contain mesh-dependent constants, and provide r…
The impact of strict and forced confinement due to the COVID-19 pandemic on positive functioning variables, emotional distress, and posttraumatic gro…
2021
ABSTRACT Background: The adverse consequences of the COVID-19 pandemic on mental health have been widely studied in recent months. However, few studies have examined the protective psychological factors that may explain how individuals are coping with the COVID-19 pandemic and its forced confinements. Objective: This study analyzes the impact of confinement due to the COVID-19 pandemic on positive functioning variables (resilience, meaning of life, gratitude, compassion, life satisfaction), emotional distress (depression, anxiety, perceived stress, affect), and posttraumatic growth (PTG). The impact was measured during and after the first month of strict and obligatory confinement in Spain.…
Consumption of spices and ethnic contamination in the daily diet of Italians - consumers’ preferences and modification of eating habits
2021
AbstractCurrently, consumers appear to have diversified characteristics with regard to food tastes and consumption habits. The globalization of markets and the migration phenomenon contributed to the modification of food preferences of consumers who gradually introduce into their eating habits foods and recipes typical of the tradition of foreign countries. In this scenario, also in Italy, it is going to increase the use of “foreign products” with the consequent fusion of traditional cuisine techniques and recipes with ingredients that are typical of foreign countries and cultures. Foods and ingredients originally consumed in Asian or South American countries are increasingly consumed by It…
Intermittent decoherence blockade in a chiral ring environment
2021
It has long been recognized that emission of radiation from atoms is not an intrinsic property of individual atoms themselves, but it is largely affected by the characteristics of the photonic environment and by the collective interaction among the atoms. A general belief is that preventing full decay and/or decoherence requires the existence of dark states, i.e., dressed light-atom states that do not decay despite the dissipative environment. Here, we show that, contrary to such a common wisdom, decoherence suppression can be intermittently achieved on a limited time scale, without the need for any dark state, when the atom is coupled to a chiral ring environment, leading to a highly non-e…
Risk for non-AIDS-defining and AIDS-defining cancer of early versus delayed initiation of antiretroviral therapy
2021
BACKGROUND: Immediate initiation of antiretroviral therapy (ART) regardless of CD4 cell count reduces risk for AIDS and non-AIDS-related events in asymptomatic, HIV-positive persons and is the standard of care. However, most HIV-positive persons initiate ART when their CD4 count decreases below 500 × 10 9 cells/L. Consequences of delayed ART on risk for non-AIDS-defining and AIDS-defining cancer, one of the most common reasons for death in HIV, are unclear. OBJECTIVE: To estimate the long-term risk difference for cancer with the immediate ART strategy.DESIGN: Multinational prospective cohort study.SETTING: The D:A:D (Data collection on Adverse events of anti-HIV Drugs) study, which included…
The Eveningness Chronotype and Lower Adherence to the Mediterranean Diet Are Associated With Depressive Symptoms in Older Subjects With Metabolic Syn…
2021
OBJECTIVES: Studies have shown the importance of depression as a risk factor for several diseases. Likewise, currently there is great interest on the role of chronotype in depressive disorders. Similarly, associations between diet and depression have been reported. However, very few studies have analyzed the combined effect of diet and chronotype on depression. Our aim was to investigated the joint influence of the morning/evening chronotype and adherence to the Mediterranean diet (MeDiet) on depressive symptoms in older subjects with metabolic syndrome. METHODS: We analyzed 465 PREDIMED Plus-Valencia study participants (aged 55–75). We assessed depressive symptoms by the Beck Depression In…
Cerebellum and Prematurity: A Complex Interplay Between Disruptive and Dysmaturational Events.
2021
The cerebellum plays a critical regulatory role in motor coordination, cognition, behavior, language, memory, and learning, hence overseeing a multiplicity of functions. Cerebellar development begins during early embryonic development, lasting until the first postnatal years. Particularly, the greatest increase of its volume occurs during the third trimester of pregnancy, which represents a critical period for cerebellar maturation. Preterm birth and all the related prenatal and perinatal contingencies may determine both dysmaturative and lesional events, potentially involving the developing cerebellum, and contributing to the constellation of the neuropsychiatric outcomes with several impl…
SAKK 36/13 ‐ IBRUTINIB PLUS BORTEZOMIB AND IBRUTINIB MAINTENANCE FOR RELAPSED AND REFRACTORY MANTLE CELL LYMPHOMA: FINAL REPORT OF A PHASE I/II TRIAL…
2021
Book reviews: La muerte del verdugo. Reflexiones interdisciplinarias sobre el cadáver de los criminales de masa
2021
Riannodare passato e presente con le foto d’archivio. Ricostruzione della chiesa delle Stimmate di Palermo
2021
La restituzione prospettica è stata pressoché ignorata nelle ricerche incentrate sulla ricostruzione di architetture e contesti urbani da foto d’archivio, a causa dell’ampio margine di approssimazione che caratterizzava il processo di restituzione condotto con gli strumenti tradizionali del disegno. Gli strumenti digitali per la rappresentazione riducono sensibilmente il margine di approssimazione e permettono di ricostruire direttamente nello spazio tridimensionale le opere che compaiono in una singola immagine fotografica. Il caso studio prescelto è la chiesa delle Stimmate di Palermo, demolita alla fine del XIX secolo per la costruzione del teatro Massimo, principale teatro lirico della …
Fire frequency during the Holocene in central Latvia, northeastern Europe
2021
Fire is today a pan-European issue and is expected to be more salient because of climate and land use changes. Even though natural and anthropogenic fires have shaped forest composition and landscape characteristics since the last glacial retreat from northeastern Europe, fire frequency is an understudied topic. To address this issue, we analysed macroscopic charcoal (>160 μm) from two sediment sequences located in the central and littoral parts of Lake Bricu (central Latvia) revealing the fire frequency during the Holocene. The chronology of the analysed sediment sequences is based on spheroidal fly-ash carbonaceous particles and accelerator mass spectrometry radiocarbon dating. Macroscop…
Narrative Tensions in Strained Junior Elite Performers’ Experiences of Becoming Elite Performers
2021
Contextualized within narrative theory and the field of talent identification and development systems (TIDS), this interview study examined strained junior elite performers’ experiences of becoming elite performers while participating in prestigious national TIDS. The study explored how junior elite performers perceive and negotiate their personal narratives of becoming within a cultural master narrative of being. The focus is on how the quality of person-environment interaction, characterized by narrative alignment or tensions, relates to perceptions of identity, agency, and physical and mental health. We purposefully recruited eight participants (Mage = 17.31, SD = 0.9) from a previously …
Immediate Effects of Prescribed Burning on Soil Mite (Acari: Oribatida) Communities in a Scots Pine (Pinus Sylvestris) Forest, Latvia
2021
Abstract Prescribed burning is used to maintain and restore habitats, to protect and increase species bio-diversity. Knowledge about soil fauna is limited, especially on community responses to fire disturbances. The aim of this study was to determine the immediate effects of prescribed burning on soil armoured mite (Acari: Oribatida) communities, vegetation cover and soil physiochemical properties in a boreal Scots pine forest in Latvia. Soil samples were collected on the day of the prescribed burning in the protected landscape area “Ādaži” and 16 days after. No significant changes in abiotic factors were found. Fire significantly decreased the vegetation cover. After the burning, the total…
Weak kaon production off the nucleon and Watson's theorem
2021
We have improved the tree-level model of Ref arXiv:1004.5484 [hep-ph] for weak production of kaons off nucleons by partially restoring unitarity. This is achieved by imposing Watson's theorem to the dominant vector and axial-vector contributions in appropriate angular momentum and isospin quantum number sectors. The observable consequences of this procedure are investigated.
Analysis of the Pre and Post-COVID-19 Lockdown Use of Smartphone Apps in Spain
2021
The global pandemic of COVID-19 has changed our daily habits and has undoubtedly affected our smartphone usage time. This paper attempts to characterize the changes in the time of use of smartphones and their applications between the pre-lockdown and post-lockdown periods in Spain, during the first COVID-19 confinement in 2020. This study analyzes data from 1940 participants, which was obtained both from a survey and from a tracking application installed on their smartphones. We propose manifold learning techniques such as clustering, to assess, both in a quantitative and in a qualitative way, the behavioral and social effects and implications of confinement in the Spanish population. We al…
Sex-specific differences in the presentation, clinical course, and quality of life of patients with acute venous thromboembolism according to baselin…
2021
Abstract Introduction Sex and the presence of specific provoking risk factors, along with age, influence the presentation and prognosis of venous thromboembolism (VTE). We investigated the presentation, course and quality of life in women and men with acute VTE classified according to their VTE provoking factors. Methods PREFER in VTE is an international, non-interventional registry of patients with a first episode of acute symptomatic VTE. Baseline provoking factors were classified as follows: major transient, minor transient, active cancer, and none identifiable. The primary outcome was recurrent VTE. Quality of life and treatment satisfaction were secondary outcomes. Results Of 3,455 pat…
Le premier e-congrès de la SNFMI, Dijon 2020 : impressions, ressentis et bilans
2021
Impact of Residual Mitral Regurgitation on Survival After Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation.
2021
OBJECTIVES The aim of this study was to assess the impact of residual mitral regurgitation (resMR) on mortality with respect to left ventricular dilatation (LV-Dil) or right ventricular dysfunction (RV-Dys) in patients with secondary mitral regurgitation (SMR) who underwent mitral valve transcatheter edge-to-edge repair (TEER). BACKGROUND The presence of LV-Dil and RV-Dys correlates with advanced stages of heart failure in SMR patients, which may impact the outcome after TEER. METHODS SMR patients in a European multicenter registry were evaluated. Investigated outcomes were 2-year all-cause mortality and improvement in New York Heart Association functional class with respect to MR reduction…
1,4 dihidropiridinski derivati povećavaju ekspresiju gena Psma3, Psmb5 i Psmc6 u glasničkoj RNA štakora
2021
The ubiquitin-proteasome system modifies different cellular and protein functions. Its dysregulation may lead to disrupted proteostasis associated with multiple pathologies and aging. Pharmacological regulation of proteasome functions is already an important part of the treatment of several diseases. 1,4-dihydropyridine (1,4-DHP) derivatives possess different pharmacological activities, including antiaging and neuroprotective. The aim of this study was to investigate the effects of several 1,4-DHP derivatives on mRNA expression levels of proteasomal genes Psma3, Psmb5, and Psmc6 in several organs of rats. Rats were treated with metcarbatone, etcarbatone, glutapyrone, styrylcarbatone, AV-153…
Physics of agarose fluid gels: Rheological properties and microstructure
2021
Agarose, a strongly gelling polysaccharide, is a common ingredient used to optimize the viscoelastic properties of a multitude of food products. Through aggregation of double helices via hydrogen bonds while cooling under quiescent conditions it forms firm and brittle gels. However, this behavior can be altered by manipulating the processing conditions viz shear. For example, gelation under shear leads to microgel particles with large surface area, which in turn leads to completely different rheological properties and texture. Such fluid gels are shown to play an important role in texture modification of foods and beverages for dysphagia patients. In this study, different concentration of a…
Evaluation of routing policies using an interval-valued TOPSIS approach for the allocation rules
2021
Abstract The success of warehouse management in a supply chain widely depends on an efficient and effective retrieve of customer orders, which is known as the picking process. This paper investigates various routing policies of pickers under two different allocation methods of items in a warehouse of fixed layout, and evaluates their performance in terms of the resulting travel distance by means of a simulation approach. The allocation strategies taken into account are the random storage and a multi-criteria approach, called Interval-Value TOPSIS (IV-T), which is expressively proposed in this paper as a new way to solve the storage allocation problem of items in a warehouse. Because of the …
Employee trust repair: A systematic review of 20 years of empirical research and future research directions
2021
Employee trust, and increasingly its absence, is a critical topic for researchers and practitioners interested in social relations in the context of work and organizing. Employee trust repair is particularly important in the current disrupted work environment, due to unpredictable changes such as the Covid-19 pandemic and the uncertainty those bring to our lives. It is not surprising that employee trust is attracting increasing interest among researchers and practitioners alike. In this article, we systematically review and take stock of the research on trust repair conducted in the past two decades to provide comprehensive insights and future research directions for researchers and manager…
Compact Cell Imaging Device (CoCID) provides insights into the cellular origins of viral infections
2021
The overall CoCID concept is centred on providing virologists with a next-generation imaging device, which, through increased penetration and depth of focus, as well as through high natural contrast and sensitivity to organelle density (including virus-related organelles), will produce higher-fidelity ultrastructural images of whole intact cells. These insights will, in turn, help increase our understanding of the links between the structural reorganisation of cells and the mechanisms of viral entry, replication, assembly, and egress in cells. CoCID will provide this valuable imaging capability in the form of a compact lab-scale device that will greatly improve the accessibility of soft X-r…
Low awareness and common misconceptions about schistosomiasis in endemic lowland areas in Western Ethiopia: a mixed-methods study
2021
Abstract Background Understanding the health behavior of the target population is crucial for sustainable schistosomiasis control. The aim of this study was to assess schistosomiasis related levels of knowledge, attitude, and practices of communities in lowland areas of western Ethiopia, where schistosomiasis is endemic. Methods A community-based multilevel triangulation mixed-methods design was conducted in three schistosomiasis endemic villages in the Abbey and Didessa valleys of the Benishangul Gumuz Region of Western Ethiopia, where mass drug administration (MDA) was done 30 years back and again the last 5 years. A structured survey questionnaire, in-depth interviews, focused group disc…
Electrodialysis with asymmetrically profiled membranes: Influence of profiles geometry on desalination performance and limiting current phenomena
2021
Abstract Electrodialysis (ED) has recently gained much attention in the wide field of desalination and water treatment. However, energy consumption and capital costs may impair the process competitiveness. In this regard, limiting current density (LCD) and current efficiency (η) are key performance parameters for optimized ED systems. In this work, an experimental campaign was carried out characterizing the performance of ED stacks when adopting asymmetrically profiled membranes. Current–voltage curves were recorded under different operating conditions mimicking the operation of brackish water or seawater desalination units. Results showed that there was a preferable direction of the electr…
“As Many as Possible for as Long as Possible”—A Case Study of a Soccer Team That Fosters Multiple Outcomes
2021
The personal assets framework suggests that dynamic elements of (a) personal engagement in activities, (b) quality social dynamics, and (c) appropriate settings will influence an athlete’s long-term outcomes of performance, personal development, and continued participation in sport. The aim of the present study was to conduct a case study of a Norwegian age-restricted team that was successful in promoting participation, performance, and positive development for individual participants and to investigate how the dynamic elements of activities, social dynamics, and settings have led to these long-term outcomes. The results indicated that the case is a best-practice example of successful attai…
The Riga East University Hospital Stroke Registry—An Analysis of 4915 Consecutive Patients with Acute Stroke
2021
Background and Objectives: A hospital-based stroke registry is a useful tool for systematic analyses of the epidemiology, clinical characteristics, and natural course of stroke. Analyses of stroke registry data can provide information that can be used by health services to improve the quality of care for patients with this disease. Materials and Methods: Data were collected from the Riga East University Hospital (REUH) Stroke Registry in order to evaluate the etiology, risk factors, clinical manifestations, treatment, functional outcomes, and other relevant data for acute stroke during the period 2016–2020. Results: During a five-year period, 4915 patients (3039 females and 1876 males) with…
Short-Term Effects on Gene-Expression and on DNA-Methylation at the Genome-Wide Level of the Iberian Ham Intake and Compared With Orange Intake: A Cr…
2021
OBJECTIVES: Diet regulates gene expression and methylation profiles by several mechanisms. However, studies analyzing the simultaneous effect of specific foods on gene-expression and DNA methylation at the genome-wide level are very scarce. Therefore our aims were: To study the short-term transcriptomics and epigenomcis effects at the genome-wide level of the Iberian ham intake compared with orange intake in the same subjects. METHODS: We carried out a cross-over randomized trial (registered at ISRCTN17906849) in 33 healhty volunteers (aged 18–50 years and 50% females) of European ancestry. After 12h fasting, participants were randomly allocated to eat 67.5 g of Iberian ham (100% pure iberi…