showing 36 of ~574560 from 574555 documents
Dance movement therapy for depressed clients : Profiles of the level and changes in depression
2021
This research identified participant profiles in level and changes in depression among working age (18–64 years old) clients (N = 137) diagnosed with depression, who participated in a 20-session dance movement therapy (DMT) intervention. Using Latent Profile Analysis Mild, sharply reducing depression (9%), Mild, reducing depression (58%) and Severe, reducing depression (33%) profiles were established, using Beck Depression Inventory scores gathered at pre-intervention, post-intervention, and follow-up points. At the pre-intervention point, being in full-time work was related to the Mild, sharply reducing depression profile. Being on a disability pension, having a history of one's own or a c…
Sustainability and risk perception: multidisciplinary approaches
2021
Editorial to the special issue "Sustainability and risk perception: multidisciplinary approaches"
Maym: le acque
2021
IL VALORE SIMBOLICO DELL'ACQUA , MAYIM, NELL'EBRAISMO: ELEMENTI RELIGIOSI E CULTURALI
A New Score Unveils a High Prevalence of Mild Cognitive Impairment in Patients with Nonalcoholic Fatty Liver Disease
2021
Patients with nonalcoholic fatty liver disease (NAFLD) may show mild cognitive impairment (MCI). The neurological functions affected remain unclear. The aims were to: (1) Characterize the neuropsychological alterations in NAFLD patients; (2) assess the prevalence of impairment of neurological functions evaluated; (3) develop a new score for sensitive and rapid MCI detection in NAFLD; (4) assess differences in MCI features between patients with nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH); and (5) compare neuropsychological alterations in NAFLD patients with cirrhotic patients with MCI. Fifty-nine NAFLD patients and 53 controls performed psychometric tests assessin…
Semi-natural habitats in boreal Europe: a rise of a social-ecological research agenda
2021
The European continent contains substantial areas of semi-natural habitats, mostly grasslands, which are among the most endangered habitats in Europe. Their continued existence depends on some form of human activity, for either production or conservation purposes, or both. We examined the share of semi-natural grasslands within the general grassland areas in boreal Europe. We reviewed research literature across the region to compile evidence on semi-natural grasslands and other semi-natural habitats, such as wooded pastures, in respect to a range of topics such as ecology, land-use change, socioeconomics, and production. We also explored drivers of the research agenda and outlined future re…
International Virtual Mobility in Higher Education
2021
Zeitschrift für Hochschulentwicklung
The Link between Oxidative Stress, Redox Status, Bioenergetics and Mitochondria in the Pathophysiology of ALS
2021
Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease of the motor system. It is characterized by the degeneration of both upper and lower motor neurons, which leads to muscle weakness and paralysis. ALS is incurable and has a bleak prognosis, with median survival of 3–5 years after the initial symptomatology. In ALS, motor neurons gradually degenerate and die. Many features of mitochondrial dysfunction are manifested in neurodegenerative diseases, including ALS. Mitochondria have shown to be an early target in ALS pathophysiology and contribute to disease progression. Disruption of their axonal transport, excessive generation of reactive oxygen species, disruptio…
Immune Thrombocytopenia: Recent Advances in Pathogenesis and Treatments
2021
Immune thrombocytopenia (ITP) is a rare autoimmune disease due to both a peripheral destruction of platelets and an inappropriate bone marrow production. Although the primary triggering factors of ITP remain unknown, a loss of immune tolerance—mostly represented by a regulatory T-cell defect—allows T follicular helper cells to stimulate autoreactive splenic B cells that differentiate into antiplatelet antibody-producing plasma cells. Glycoprotein IIb/IIIa is the main target of antiplatelet antibodies leading to platelet phagocytosis by splenic macrophages, through interactions with Fc gamma receptors (FcγRs) and complement receptors. This allows macrophages to activate autoreactive T cells …
Valutazione dei cambiamenti qualitativi di frutti di pero trattati con edible coating in post-raccolta
2021
La pera è un frutto climaterico caratterizzato da intensa attività metabolica post-raccolta, fattore che inficia notevolmente le sue caratteristiche qualitative pregiudicandone la shelf-life e obbligando gli attori economici a ricorrere a costosi metodi di condizionamento come la frigoconservazione anche quando il prodotto è destinato al consumo fresco con un conseguente aumento dei costi in fase distributiva e di commercializzazione. Lo scopo del presente lavoro è stato quello di studiare gli effetti di diversi edible coating, barriere selettive edibili facilmente realizzabili con matrici a basso costo ed ecocompatibili in grado di preservare il prodotto, su frutti di pero al fine di indiv…
Prevision model and empirical test of box office results for sequels
2021
International audience; As studios release an increasing number of movie sequels, scholars have begun to examine this strategic choice. Prior studies use standard models of box office performance to evaluate sequels’ performance and have mainly compared the box office results of the original movie with those of its sequel. However, sequels hold a unique position in the motion picture market since they are strongly associated with the original movie. Using the accessibility-diagnosticity framework, this research investigates the drivers behind the success of sequels and examines specifically the original movie’s impact through the role of reviews. The results – from 232 movies (116 original …
Beyond the Paradigm of Weight Loss in Non-Alcoholic Fatty Liver Disease: From Pathophysiology to Novel Dietary Approaches
2021
Current treatment recommendations for non-alcoholic fatty liver disease (NAFLD) rely heavily on lifestyle interventions. The Mediterranean diet and physical activity, aiming at weight loss, have shown good results in achieving an improvement of this liver disease. However, concerns related to compliance and food accessibility limit the feasibility of this approach, and data on the long-term effects on liver-related outcomes are lacking. Insulin resistance is a central aspect in the pathophysiology of NAFLD; therefore, interventions aiming at the improvement of insulin sensitivity may be preferable. In this literature review, we provide a comprehensive summary of the available evidence on nu…
Prefazione a: Amo, ergo sum
2021
The preface to the volume: Amo ergo sum, focuses on the concept of cosmic love present in all the literary production of Nikiforos Vrettakos
PIECEWISE ANOMALY DETECTION USING MINIMAL LEARNING MACHINE FOR HYPERSPECTRAL IMAGES
2021
Abstract. Hyperspectral imaging, with its applications, offers promising tools for remote sensing and Earth observation. Recent development has increased the quality of the sensors. At the same time, the prices of the sensors are lowering. Anomaly detection is one of the popular remote sensing applications, which benefits from real-time solutions. A real-time solution has its limitations, for example, due to a large amount of hyperspectral data, platform’s (drones or a cube satellite) constraints on payload and processing capability. Other examples are the limitations of available energy and the complexity of the machine learning models. When anomalies are detected in real-time from the hyp…
The C-X-C Motif Chemokine Ligand 1 Sustains Breast Cancer Stem Cell Self-Renewal and Promotes Tumor Progression and Immune Escape Programs
2021
Breast cancer (BC) mortality is mainly due to metastatic disease, which is primarily driven by cancer stem cells (CSC). The chemokine C-X-C motif ligand-1 (CXCL1) is involved in BC metastasis, but the question of whether it regulates breast cancer stem cell (BCSC) behavior is yet to be explored. Here, we demonstrate that BCSCs express CXCR2 and produce CXCL1, which stimulates their proliferation and self-renewal, and that CXCL1 blockade inhibits both BCSC proliferation and mammosphere formation efficiency. CXCL1 amplifies its own production and remarkably induces both tumor-promoting and immunosuppressive factors, includingSPP1/OPN,ACKR3/CXCR7,TLR4,TNFSF10/TRAILandCCL18and, to a lesser exte…
Dimensions of Community Assets for Health. A Systematised Review and Meta-Synthesis
2021
Since Aaron Antonovsky’s salutogenesis theory and Morgan and Ziglio’s health assets model were first proposed, there has been a growing concern to define the resources available to the individual and the community to maintain or improve health and well-being. The aim of the present study was to identify the dimensions that characterise community assets for health. To this end, we conducted a systematised review with a meta-synthesis and content analysis of research or projects involving asset mapping in the community. Articles that met our eligibility criteria were: (1) based on the salutogenic approach and (2) described an assets mapping process and among their results, explained what, how…
Beyond Evidentiality. The epistemic function of the suffix -wa in Aymara
2021
In contrast to the specialized literature (Hardman 1986, 2001; Martinez-Vera 2020), this paper questions the direct evidential function of the sentence-type suffix -wa in «Northern Aymara» (Cerrón-Palomino 2000), an understudied Andean language spoken in the area around Lake Titicaca. By taking a narrow perspective on evidentiality, it proposes that -wa is a modal epistemic marker that indicates the speaker’s high commitment to information. Semantic considerations that support this proposal focus on both the interplay of -wa with other grammatical categories and its distribution within the sentence. Additionally, considerations on the scope properties of the suffix, as applied by Hengeveld …
Electricity demand response schemes in China: Pilot study and future outlook
2021
Abstract Electricity demand response (DR) improves the overall energy management efficiency and allows for the integration of large-scale renewable energy into the power grid through interactive management and control of the supply and demand sides. However, in China and other emerging countries (e.g., Japan and Australia) with DR programs, the DR market mechanism is not well-established. This is particularly the situation in countries where the state power system is not freely open to participate in the DR market. Previous research has proven that considerable DR resources are largely existing in the demand side; however, the dearth of a market mechanism hinders the development of DR. Henc…
Angioedema Coexisting Chronic Spontaneous Urticaria Negatively Influences Patients’ Sense of Coherence, What Results in Susceptibility to Anxiety Sym…
2021
Background: Angioedema coexisting chronic spontaneous urticaria (CSU) is proved to result in patient anxiety occurrence, but the mechanisms and susceptibility patterns are unknown. Sense of coherence (SOC) is one of methods of coping with stress and is defined as a person’s general orientation toward life. We decided to assess SOC disturbances in CSU patients in the context of possible angioedema association. Methods: The study comprised 71 CSU subjects. To analyze disease activity, the Urticaria Activity Score seven-day assessment questionnaire (UAS7) was used. For anxiety assessment, the STAI questionnaire was used. The SOC-29 questionnaire, consisting of questions related to comprehensib…
Energy spectral density as valid parameter to compare postural control between subjects with nonspecific chronic low back pain vs healthy subjects : …
2021
Abstract Background Nonspecific chronic low back pain (NSCLBP) is one of the most common and frequent health problems. Objetive to compare postural control (i.e. center of pressure (CoP) displacement and energy spectral density (ESD)) using technological devices (accelerometers and pressure platform) between subjects with NSCLBP and healthy subjects. Methods A cross-sectional case-control study was conducted. Observational study (STROBE). The final sample consisted of 60 subjects (30 NSCLBP subjects and 30 healthy subjects). Triaxial accelerometer and pressure platform were used in order to obtain ESD and CoP displacement measurements during four balance tasks (i.e. with and without vision …
The Dual Role of the GABAA Receptor in Peripheral Inflammation and Neuroinflammation: A Study in Hyperammonemic Rats
2021
Cognitive and motor impairment in minimal hepatic encephalopathy (MHE) are mediated by neuroinflammation, which is induced by hyperammonemia and peripheral inflammation. GABAergic neurotransmission in the cerebellum is altered in rats with chronic hyperammonemia. The mechanisms by which hyperammonemia induces neuroinflammation remain unknown. We hypothesized that GABAA receptors can modulate cerebellar neuroinflammation. The GABAA antagonist bicuculline was administrated daily (i.p.) for four weeks in control and hyperammonemic rats. Its effects on peripheral inflammation and on neuroinflammation as well as glutamate and GABA neurotransmission in the cerebellum were assessed. In hyperammone…
β2-adrenoreceptors control human skin microvascular reactivity.
2021
Topical α1- and α2-adrenoreceptor (ADRA1 and 2) agonists are effective in alleviating permanent vasodilation and facial erythema associated with rosacea by inducing skin vasoconstriction. Although β-adrenoreceptor (ADRB) antagonists are used off-label for rosacea, pharmacological and pharmacodynamic data pertaining to these receptors in skin micro-vessels are lacking. Objectives: To analyse the expression of different adrenergic receptors and their contribution to vasoreactivity in skin micro-vessels. Small arteries (500-800 μm) and arterioles (<200 μm) were studied in human foreskin tissue. Specifically, ADR-A1, -A2, -B1 and -B2 expression was assayed by immunofluorescence, polymerase chai…
Mettre le chocolat en mots : terminologie de filière ou commerciale ?
2021
International audience; Ce chapitre interroge les terminologies mises en œuvre pour la description organoleptique et hédonique de la fève de cacao produite en Equateur et approchée à partir de la dégustation du produit fini qu’est le chocolat. Il s’arrête en particulier sur les modalités de construction de ces terminologies dans le contexte local spécifique qui repose tout à la fois sur une dichotomie entre la culture de la fève et sa transformation en chocolat et sur la situation diglossique du pays entre langues natives pour les producteurs et espagnol pour les exportateurs et aficionados à l’origine d’un discours largement prescriptif. Affichant une orientation éminemment méthodologique,…
Sensitivity and Specificity of Human Papillomavirus (HPV) 16 Early Antigen Serology for HPV-Driven Oropharyngeal Cancer: A Systematic Literature Revi…
2021
Simple Summary Serum antibodies against human papillomavirus 16 (HPV16) proteins are associated with HPV-driven oropharyngeal cancer (HPV-OPC). The HPV status of OPC cases is clinically relevant because patients with HPV-OPC show improved survival and treatment response compared to tobacco- or alcohol-induced OPC. In clinical settings, molecular HPV tumor status is usually determined by tissue-based methods detecting molecular markers, such as viral nucleic acids or p16 overexpression. Antibodies against HPV16 in peripheral blood were shown to be very accurate in determining the molecular HPV tumor status in multiple studies. In this work, we reviewed and summarized the available literature…
Shoulder ultrasound: current concepts and future perspectives
2021
Ultrasonography is an established and effective imaging technique that can be used to evaluate articular and periarticular structures around the shoulder. It has been shown to be useful in a wide range of rotator cuff diseases (e.g. tendon tears, rotator cuff calcific tendinopathy and bursitis) as well as non-rotator cuff abnormalities (instability, synovial joint diseases and nerve entrapment syndrome). A scanning protocol is highly recommended to reduce the rate of operators’ errors by following a standardized scheme including a list of main structures. Shoulder ultrasound has several advantages: it is a relatively cheap and widely available technique, free from ionizing radiation, that c…
Treatment of Gingival Recession: When and How?
2021
Gingival recession is a common finding in daily clinical practice. Several issues may be associated with the apical shift of the gingival margin such as dentine hypersensitivity, root caries, non-carious cervical lesions (NCCLs), and compromised aesthetics. The first step in an effective management and prevention program is to identify susceptibility factors and modifiable conditions associated with gingival recession. Non-surgical treatment options for gingival recession defects include establishment of optimal plaque control, removal of overhanging subgingival restorations, behaviour change interventions, and use of desensitising agents. In cases where a surgical approach is indicated, co…
Physical Activity, Sedentary Behavior, and Time in Bed Among Finnish Adults Measured 24/7 by Triaxial Accelerometry
2021
Background: Studies measuring physical activity (PA) and sedentary behavior on a 24/7 basis are scarce. The present study assessed the feasibility of using an accelerometer at the hip while awake and at the wrist while sleeping to describe 24/7 patterns of physical behavior in working-aged adults by age, sex, and fitness. Methods: The study was based on the FinFit 2017 study where the physical behavior of 20- to 69-year-old Finns was assessed 24/7 by triaxial accelerometer (UKKRM42; UKK Terveyspalvelut Oy, Tampere, Finland). During waking hours, the accelerometer was kept at the right hip and, during time in bed, at the nondominant wrist. PA variables were based on 1-min exponential moving …
Analysis of Rectangular Orthotropic Membranes for Mechanical Properties Identification through Load-Displacement Data
2021
In this paper, an innovative procedure is introduced for the identification of the mechanical properties of orthotropic membranes based on load-displacement data. To this end, novel functional forms of the displacement components for rectangular membranes are appropriately introduced. Unknown coefficients of these displacement functions are determined, minimizing the total potential energy of the membrane. The energy method is then combined with an optimization procedure to estimate the elastic constants of the membranes in a straightforward manner. Specifically, a genetic algorithm is used to minimize a properly defined objective function directly related to the sought mechanical propertie…
Evaluation of the AVHRR surface reflectance long term data record between 1984 and 2011
2021
Abstract The long-term data record (LTDR) from the Advanced Very High-Resolution Radiometer (AVHRR) provides daily surface reflectance with global coverage from the 1980s to present day, making it a unique source of information for the study of land surface properties and their long-term dynamics. Surface reflectance is a critical input for the generation of products such as vegetation indices, albedo, and land cover. Therefore, it is of utmost importance to quantify its uncertainties to better understand how they might propagate into downstream products. Due to the prolonged length of the surface reflectance LTDR and previous unavailability of a well calibrated reference, no comprehensive …
State Formation in Early Modern Alsace (1648–1789), by Stephen A. Lazer
2021
Cytoprotective Effects of Fish Protein Hydrolysates against H2O2-Induced Oxidative Stress and Mycotoxins in Caco-2/TC7 Cells
2021
Many studies report the potent antioxidant capacity for fish protein hydrolysates, including radical scavenging activity and inhibition ability on lipid peroxidation (LPO). In this study, the in vitro cytotoxicity of protein hydrolysates from different salmon, mackerel, and herring side streams fractions was evaluated in the concentration range from 1 to 1:32 dilution, using cloned human colon adenocarcinoma cells TC7 (Caco-2/TC7) by MTT and PT assays. The protein hydrolysates’ antioxidant capacity and oxidative stress effects were evaluated by LPO and reactive oxygen species (ROS) generation, respectively. The antioxidant capacity for pure and bioavailable hydrolysate fraction was also eva…
La distribución espacial de hogares perceptores de prestaciones económicas individualizadas: una comparación de casos
2021
El análisis de las desigualdades socioespaciales ha constituido una línea de investigación destacada en el ámbito de las ciencias sociales. No obstante, la cuestión de la desigual proyección territorial de las políticas sociales en el interior de las ciudades ha recibido una menor atención académica. En este artículo se analizan, desde una perspectiva comparada, los patrones de distribución espacial de los hogares perceptores de Prestaciones Económicas Individualizadas (PEI) en dos municipios de la Comunidad Valenciana (España): Bétera y Torrent. Para ello, se implementan distintas técnicas de análisis de puntos espaciales y de Análisis Exploratorio de Datos Espaciales (AEDE). Los resultado…
Optogenetically Controlled Activity Pattern Determines Survival Rate of Developing Neocortical Neurons
2021
A substantial proportion of neurons undergoes programmed cell death (apoptosis) during early development. This process is attenuated by increased levels of neuronal activity and enhanced by suppression of activity. To uncover whether the mere level of activity or also the temporal structure of electrical activity affects neuronal death rates, we optogenetically controlled spontaneous activity of synaptically-isolated neurons in developing cortical cultures. Our results demonstrate that action potential firing of primary cortical neurons promotes neuronal survival throughout development. Chronic patterned optogenetic stimulation allowed to effectively modulate the firing pattern of single ne…
Prognostic value of soluble urokinase plasminogen activator receptor in patients presenting to the emergency department with chest pain suggestive of…
2021
International audience; INTRODUCTION: Soluble urokinase plasminogen activator receptor (suPAR) is a prognostic biomarker of cardiovascular disease. OBJECTIVES: We aimed to evaluate the early prognostic value of suPAR in patients presenting to the emergency department (ED) with chest pain suggestive of acute coronary syndrome (ACS). PATIENTS AND METHODS: In a post-hoc analysis from a multicenter study including patients with a chest pain < 6 h, suPAR concentrations at ED admission were studied according to the outcome at 30-days. RESULTS: 198 patients (median age 56 years) in whom 16% had an ACS, were included. Fifteen (7.3%) patients presented a 30-day event. At ED admission, median (IQR…
Mechanistic study on the metallocene-based tandem catalytic coordinative chain transfer polymerization for the synthesis of highly branched polyolefi…
2021
Abstract Creation and control of long-chain branches (LCBs) in coordination polymerization of olefins is an enduring focus of research in both academia and industry. We have recently introduced a tandem catalytic coordinative chain transfer polymerization reaction where upon the concerted function of the polymerization catalyst, the chain transfer agent (CTA), and the displacement catalyst, a highly branched microstructure can be formed. Here we introduce a new tandem catalytic system using Et(Ind)2ZrCl2 as the polymerization catalyst. Despite the optimal reaction temperature for the cooperative function of catalyst components is lower than the ideal temperature for the productivity of the …
Effect of over-the-counter whitening strips and toothpaste on shear bond strength of orthodontic brackets
2021
Background To investigate: 1) the effects of over-the-counter white strip enamel bleaching and 2-Step whitening toothpaste application on the shear bond strength of orthodontic brackets at 24-hours and 7-days post-bleaching latent period; and 2) the correlation between amount of bleaching and shear bond strength. Material and Methods Sixty human premolar teeth were randomly assigned into two bleaching groups, white strip group treated with Crest® 3D WHITE™ LUXE Professional Effects Whitestrips (Proctor & Gamble, Greensboro, NC), and whitening toothpaste group, treated with Crest® 3D WHITE™ BRILLIANCE 2-Step Toothpaste (Proctor & Gamble, Greensboro, NC). The groups were further divided into …
Model-Based Evaluation of Methods for Respiratory Sinus Arrhythmia Estimation
2021
OBJECTIVE: Respiratory sinus arrhythmia (RSA) refers to heart rate oscillations synchronous with respiration, and it is one of the major representations of cardiorespiratory coupling. Its strength has been suggested as a biomarker to monitor different conditions, and diseases. Some approaches have been proposed to quantify the RSA, but it is unclear which one performs best in specific scenarios. The main objective of this study is to compare seven state-of-the-art methods for RSA quantification using data generated with a model proposed to simulate, and control the RSA. These methods are also compared, and evaluated on a real-life application, for their ability to capture changes in cardior…