showing 36 of ~574560 from 574555 documents
Stoic pragmatist ethics in the time of pandemic
2021
Abstract The present paper is a response, of sorts, to the challenges of the coronavirus pandemic (COVID) and lockdown that we all must face. We have an idea of what doctors, nurses, teachers, among many of the other professions, do for the general public, but one may ask whether there is something substantial that philosophers and ethicists can offer in these circumstances. The thesis of this paper is that the stoic attitude towards times of trouble and the pragmatist way of finding out what is possible to elevate the quality of living against all odds, if skilfully interwoven, could be an important tool in keeping mental health in good shape and, additionally, could contribute to the cult…
Model-Based Evaluation of Methods for Respiratory Sinus Arrhythmia Estimation
2021
OBJECTIVE: Respiratory sinus arrhythmia (RSA) refers to heart rate oscillations synchronous with respiration, and it is one of the major representations of cardiorespiratory coupling. Its strength has been suggested as a biomarker to monitor different conditions, and diseases. Some approaches have been proposed to quantify the RSA, but it is unclear which one performs best in specific scenarios. The main objective of this study is to compare seven state-of-the-art methods for RSA quantification using data generated with a model proposed to simulate, and control the RSA. These methods are also compared, and evaluated on a real-life application, for their ability to capture changes in cardior…
Une déprise du politique ? Léon Rosenthal (1917-1923)
2021
Cet article revient sur le parcours de Leon Rosenthal, intellectuel et historien de l’art, figure des majoritaires de guerre au sein de la SFIO, dans le contexte de la sortie de guerre. Alors que ce contexte est marque par une tres forte politisation, Leon Rosenthal semble peu a peu se deprendre du politique, quittant la SFIO des novembre 1918 pour ensuite participer a la fondation de la France libre et du Parti socialiste francais, avant de s’eloigner toujours davantage, en privilegiant ses activites d’historien de l’art. Il s’agit donc d’expliquer cette distance progressive prise avec la politique, distance qui met en jeu son parcours ulterieur de socialiste d’Union sacree, et la maniere …
Development and external validation of a clinical prediction model for functional impairment after intracranial tumor surgery
2021
OBJECTIVE Decision-making for intracranial tumor surgery requires balancing the oncological benefit against the risk for resection-related impairment. Risk estimates are commonly based on subjective experience and generalized numbers from the literature, but even experienced surgeons overestimate functional outcome after surgery. Today, there is no reliable and objective way to preoperatively predict an individual patient’s risk of experiencing any functional impairment. METHODS The authors developed a prediction model for functional impairment at 3 to 6 months after microsurgical resection, defined as a decrease in Karnofsky Performance Status of ≥ 10 points. Two prospective registries in…
Predator-Induced Plasticity on Warning Signal and Larval Life-History Traits of the Aposematic Wood Tiger Moth, Arctia plantaginis
2021
Predator-induced plasticity in life-history and antipredator traits during the larval period has been extensively studied in organisms with complex life-histories. However, it is unclear whether different levels of predation could induce warning signals in aposematic organisms. Here, we investigated whether predator-simulated handling affects warning coloration and life-history traits in the aposematic wood tiger moth larva, Arctia plantaginis. As juveniles, a larger orange patch on an otherwise black body signifies a more efficient warning signal against predators but this comes at the costs of conspicuousness and thermoregulation. Given this, one would expect that an increase in predation…
Cardiac response to Nage no Kata in judo
2021
The first world judo Kata competition was held in October 2007 in Tokyo, Japan. The Nage no Kata was developed in 1884 and 1885 at the Kodokan. by Jigoro Kano, the founder of judo, who developed Kata to demonstrate the principles of judo and to provide a type of training which emphasized performing techniques under controlled setting. According to Kano, to fully develop judo skills, it is essential to involve both Randori and Kata techniques [1]. Most highgrade Japanese judo teachers emphasize the importance of Kata performance for judokas’ development, in particular Nage no Kata [2]. Results of the study conducted by Canestri et al. [3] suggested that session-RPE and HR monitoring is a sim…
Alternative Splicing of the Basic Helix–Loop–Helix Transcription Factor Gene CmbHLH2 Affects Anthocyanin Biosynthesis in Ray Florets of Chrysanthemum…
2021
Chrysanthemum is an important ornamental crop worldwide. Some white-flowered chrysanthemum cultivars produce red ray florets under natural cultivation conditions, but little is known about how this occurs. We compared the expression of anthocyanin biosynthetic and transcription factor genes between white ray florets and those that turned red based on cultivation conditions to comprehend the underlying mechanism. Significant differences in the expression of CmbHLH2 were detected between the florets of different colors. CmbHLH2 generated two alternatively spliced transcripts, designated CmbHLH2Full and CmbHLH2Short. Compared with CmbHLH2Full, CmbHLH2Short encoded a truncated protein with only…
The Evolving Role of Fetuin-A in Nonalcoholic Fatty Liver Disease: An Overview from Liver to the Heart
2021
Nonalcoholic fatty liver disease (NAFLD) is strongly associated to the features of metabolic syndrome which can progress to cirrhosis, liver failure and hepatocellular carcinoma. However, the most common cause of mortality in people with NAFLD is not liver-related but stems from atherosclerotic cardiovascular disease (CVD). The prevalence of NAFLD is on the rise, mainly as a consequence of its close association with two major worldwide epidemics, obesity and type 2 diabetes (T2D). The exact pathogenesis of NAFLD and especially the mechanisms leading to disease progression and CVD have not been completely elucidated. Human fetuin-A (alpha-2-Heremans Schmid glycoprotein), a glycoprotein produ…
La distribución espacial de hogares perceptores de prestaciones económicas individualizadas: una comparación de casos
2021
El análisis de las desigualdades socioespaciales ha constituido una línea de investigación destacada en el ámbito de las ciencias sociales. No obstante, la cuestión de la desigual proyección territorial de las políticas sociales en el interior de las ciudades ha recibido una menor atención académica. En este artículo se analizan, desde una perspectiva comparada, los patrones de distribución espacial de los hogares perceptores de Prestaciones Económicas Individualizadas (PEI) en dos municipios de la Comunidad Valenciana (España): Bétera y Torrent. Para ello, se implementan distintas técnicas de análisis de puntos espaciales y de Análisis Exploratorio de Datos Espaciales (AEDE). Los resultado…
The FRAM robotic telescope for atmospheric monitoring at the Pierre Auger Observatory
2021
FRAM (F/Photometric Robotic Atmospheric Monitor) is a robotic telescope operated at the Pierre Auger Observatory in Argentina for the purposes of atmospheric monitoring using stellar photometry. As a passive system which does not produce any light that could interfere with the observations of the fluorescence telescopes of the observatory, it complements the active monitoring systems that use lasers. We discuss the applications of stellar photometry for atmospheric monitoring at optical observatories in general and the particular modes of operation employed by the Auger FRAM. We describe in detail the technical aspects of FRAM, the hardware and software requirements for a successful operati…
The C-X-C Motif Chemokine Ligand 1 Sustains Breast Cancer Stem Cell Self-Renewal and Promotes Tumor Progression and Immune Escape Programs
2021
Breast cancer (BC) mortality is mainly due to metastatic disease, which is primarily driven by cancer stem cells (CSC). The chemokine C-X-C motif ligand-1 (CXCL1) is involved in BC metastasis, but the question of whether it regulates breast cancer stem cell (BCSC) behavior is yet to be explored. Here, we demonstrate that BCSCs express CXCR2 and produce CXCL1, which stimulates their proliferation and self-renewal, and that CXCL1 blockade inhibits both BCSC proliferation and mammosphere formation efficiency. CXCL1 amplifies its own production and remarkably induces both tumor-promoting and immunosuppressive factors, includingSPP1/OPN,ACKR3/CXCR7,TLR4,TNFSF10/TRAILandCCL18and, to a lesser exte…
Corrigendum to “European Resuscitation Council Guidelines 2021: Executive summary” [Resuscitation (2021) 1–60]
2021
UV and X-ray excited red persistent luminescence in Mn2+ doped MgGeO3 material synthesized in air and reducing atmosphere
2021
Abstract Materials with long persistent luminescence (PersL) have caused widespread interest among scientists and industry for decades. Currently, there is widely available information on the long persistent luminescence materials with emission in the blue and green spectral range, while the number of publications on the afterglow in the red and near-infrared spectral range is considerably lower. In the course of this work MgGeO3 material doped with 0.1 mol% Mn2+ was produced using solid-state reaction synthesis in ambient and reducing atmospheres. The material exhibits a broad luminescence band with a peak around 680 nm, excited by either X-rays or UV. After cessation of irradiation, the a…
Investigation of Spaceflight Induced Changes to Astronaut Microbiomes
2021
The International Space Station (ISS) is a uniquely enclosed environment that has been continuously occupied for the last two decades. Throughout its operation, protecting the health of the astronauts on-board has been a high priority. The human microbiome plays a significant role in maintaining human health, and disruptions in the microbiome have been linked to various diseases. To evaluate the effects of spaceflight on the human microbiome, body swabs and saliva samples were collected from four ISS astronauts on consecutive expeditions. Astronaut samples were analyzed using shotgun metagenomic sequencing and microarrays to characterize the microbial biodiversity before, during, and after …
The Go2School project for promoting cycling to school: A case study in Palermo
2021
Abstract The identification of transport policy measures able to reduce the use of private cars for home-to-school travel is very relevant to reduce congestion during peak hours and to ensure that the areas around schools have livable environments. An action that policymakers could apply is promoting cycling to school through the introduction of bikesharing programs and creating safe routes to school through the construction of new cycle infrastructure. The aim of the paper has been, therefore, to assess if these policies could lead the high-school students to cycle to school, considering the city of Palermo as a case study. The goal is reached through the calibration of a modal choice mode…
Global patterns and drivers of alpine plant species richness
2021
B.J.-A. was funded by the Marie Curie Clarín-COFUND program of the Principality of Asturias-EU (ACB17-26) and the Spanish Research Agency (AEI/10.13039/501100011033).
Evaluation of Shared Genetic Susceptibility to High and Low Myopia and Hyperopia
2021
Importance: Uncertainty currently exists about whether the same genetic variants are associated with susceptibility to low myopia (LM) and high myopia (HM) and to myopia and hyperopia. Addressing this question is fundamental to understanding the genetics of refractive error and has clinical relevance for genotype-based prediction of children at risk for HM and for identification of new therapeutic targets. Objective: To assess whether a common set of genetic variants are associated with susceptibility to HM, LM, and hyperopia. Design, Setting, and Participants: This genetic association study assessed unrelated UK Biobank participants 40 to 69 years of age of European and Asian ancestry. Par…
Patrimonio e progetto
2021
I siti archeologici costituiscono un territorio d’elezione per l’architettura, che si rivela indispensabile per la loro fruizione e salvaguardia. Di fatto, ogni sistema archeologico necessità, oltre che di scavi, di rilievi, di progetti e di molte altre competenze che implicano buona parte dei settori scientifico-disciplinari della cosiddetta area scientifica CUN 08a. La naturale relazione tra architettura e archeologia però, nella realtà dei fatti e al di là di una casistica nota, si scontra con una quotidianità dove con costanza i due ambiti tendono ad avere pochi punti di contatto. Tale distanza trova alimento, in prima battuta, nel sistema di vincoli esistenti che tende a escludere qual…
A Library-Based Screening Strategy for the Identification of DARPins as Ligands for Receptor-Targeted AAV and Lentiviral Vectors
2021
Delivering genes selectively to the therapeutically relevant cell type is among the prime goals of vector development. Here, we present a high-throughput selection and screening process that identifies designed ankyrin repeat proteins (DARPins) optimally suited for receptor-targeted gene delivery using adeno-associated viral (AAV) and lentiviral (LV) vectors. In particular, the process includes expression, purification, and in situ biotinylation of the extracellular domains of target receptors as Fc fusion proteins in mammalian cells and the selection of high-affinity binders by ribosome display from DARPin libraries each covering more than 1012 variants. This way, DARPins specific for the …
Verbal Fluency in Mild Alzheimer's Disease: Transcranial Direct Current Stimulation over the Dorsolateral Prefrontal Cortex
2021
Background: Recent studies showed that in healthy controls and in aphasic patients, inhibitory trains of repetitive transcranial magnetic stimulation (rTMS) over the right prefrontal cortex can improve phonemic fluency performance, while anodal transcranial direct current stimulation (tDCS) over the left prefrontal cortex can improve performance in naming and semantic fluency tasks. Objective: This study aimed at investigating the effects of cathodal tDCS over the left or the right dorsolateral prefrontal cortex (DLPFC) on verbal fluency tasks (VFT) in patients with mild Alzheimer’s disease (AD). Methods: Forty mild AD patients participated in the study (mean age 73.17±5.61 years). All part…
A 5,000-year-old hunter-gatherer already plagued by Yersinia pestis.
2021
Summary A 5,000-year-old Yersinia pestis genome (RV 2039) is reconstructed from a hunter-fisher-gatherer (5300–5050 cal BP) buried at Riņņukalns, Latvia. RV 2039 is the first in a series of ancient strains that evolved shortly after the split of Y. pestis from its antecessor Y. pseudotuberculosis ∼7,000 years ago. The genomic and phylogenetic characteristics of RV 2039 are consistent with the hypothesis that this very early Y. pestis form was most likely less transmissible and maybe even less virulent than later strains. Our data do not support the scenario of a prehistoric pneumonic plague pandemic, as suggested previously for the Neolithic decline. The geographical and temporal distributi…
Association between Food Insecurity and Sarcopenia among Adults Aged ≥65 Years in Low- and Middle-Income Countries
2021
Limited literature has investigated the association between food insecurity and sarcopenia in low- and middle-income countries (LMICs). Therefore, the aim of the present study was to investigate the association between food insecurity and sarcopenia among adults aged ≥65 years in six LMICs. Community-based cross-sectional data of the Study on Global Ageing and Adult Health were analyzed. Sarcopenia was defined as the presence of low skeletal muscle mass based on indirect population formula, and either slow gait or low handgrip strength. In the past, 12-month food insecurity was assessed with two questions on frequency of eating less and hunger due to lack of food. Multivariable logistic reg…
"Over the last hill": Wilfred Owen's "Spring Offensive"
2021
Being the poet’s last completed piece, “Spring Offensive” makes France Wilfred Owen’s last poetic landscape. The article explores the ways in which “Spring Offensive” continuously crosses and blurs the borders between the French landscape and the poet’s English heritage; it also emphasizes the sensuousness of the landscape and of the war experience, so that the bodies of the soldiers and nature fuse and interact. “Spring Offensive” thus comes to reflect Owen’s search for balance, a search of which the French landscape becomes the natural yet symbolic representation.
Impact of supplementation with vitamins B 6 , B 12 , and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impair…
2021
Hyperhomocysteinemia is an independent predictor of the risk for cognitive decline and may be a result of low levels of vitamins B12 , B6 , and folate. Previous findings suggest that adequate intake of these vitamins may reduce homocysteine levels. This review aimed to assess the effects of treatment with vitamins B6, B12 , and/or folic acid in the homocysteine levels in patients with mild cognitive impairment (MCI). A systematic literature review was conducted in EMBASE, MEDLINE®, PsycINFO, and Cochrane Central Register of Controlled Trials. The research question was formulated using the Population, Intervention, Comparison, and Outcome (PICO) framework: in patients with MCI (P); what is t…
false
2021
The present study was conducted with the aim of constructing and validating a short form of the Profile of Mood States (POMS). The POMS is a widely-applied measure for the assessment of an individual's mood. Thus, it is of great relevance for many research questions in clinical and social psychology. To develop the short scale, we first examined psychometric properties and found the optimal 16-item solution among all valid combinations of the full POMS in an exploratory subsample (n = 1,029) of our complete representative sample of the German general population. We then validated this model in a confirmatory subsample (n = 977). Additionally, we examined its invariance across age groups and…
«I Can?t Get the Practical Hours» : Care, Course Choice and Role Conflict Among Student-Mothers in Higher Education in Scotland
2021
Mothers who study at a higher education level face many challenges that traditional students do not. They have less time to study and must negotiate their different commitments and responsibilities, which includes taking care of their children. This article reports on qualitative research conducted with a small group of mothers that study at a prestigious university in Scotland to understand their experiences of belonging to the space of the institution and their perceived learning challenges. Four interviews and one focus group were organised, voice recorded and their transcripts were thematically analysed and engaged with the research questions. It has found that they experience limited s…
Experiences of using the ISBAR tool after an intervention: A focus group study among critical care nurses and anaesthesiologists.
2021
Objective The ISBAR tool is a structured approach to communication between healthcare professionals and refers to Identity, Situation, Background, Assessment, and Recommendation. The objective of this study was to explore how critical care nurses and anaesthesiologists experience using the ISBAR tool in clinical practice. Design Three focus groups were conducted with a total of three anaesthesiologists and 14 critical care nurses from two hospitals in Norway after they had attended an intervention. Setting The intervention consisted of two days at a university, with a four-month interval between, attending resource lectures and simulation exercises focusing on the ISBAR tool. The focus grou…
Lingua, stile e metodo nella prassi traduttiva novecentesca della lirica di Luis Cernuda
2021
Riassunto: Lo studio, incentrato sulle traduzioni novecentesche della lirica di Luis Cernuda, indaga la ricezione italiana del grande autore de La Realidad y el deseo, in particolare soffermandosi sulle prassi traduttive che ne hanno veicolato la diffusione. Il confronto di Quisiera estar solo en el sur (Un rio, un amor) nelle versioni di Bo, Macri e Tentori Montalto, fa emergere la presenza di un comune modello traduttologico dall’alto gradiente di consapevolezza formale. Un modello colto e raffinato, e la cui incidenza e durata non vanno separate da un’ulteriore necessaria considerazione sulla perifericita, rispetto al canone europeo, patita dalla letteratura spagnola nella cultura italia…
El Llibre de cetreria del vescomte de Rocabertí
2021
Resum: En el present article oferim una edició crítica del Llibre de cetreria, un breu tractat de falconeria escrit en català i conservat en manuscrit únic pertanyent a una col·lecció privada. També n’estudiem l’estructura i el contingut, a més de les relacions amb altres obres de falconeria, especialment les escrites a la Corona d’Aragó. Oferim una hipòtesi sobre la identificació del seu autor i l’època de la composició del tractat. Com que es tracta de l’obra escrita en català que major nombre d’ocells de caça esmenta, a la present edició ens ha semblant oportú de fer una exposició detallada de les aus emprades pels caçadors, com també tota la terminologia que la llengua catalana va desen…
Effects of Rapid Weight Loss on Kidney Function in Combat Sport Athletes
2021
Even though scientific literature shows numerous heath complications and performance decrements associated with rapid weight loss (RWL), its prevalence remains exceedingly high across various combat sports. The aim of this study was to thoroughly search the existing literature to explore the influence of RWL on kidney function in Olympic and non-Olympic combat sport athletes. PubMed and Web of Science were searched for the relevant studies. Only original articles published from 2005 onwards, written in English, that included healthy males and females who prompted ~5% weight loss within a week or less, were included in the study. Retrieved studies showed that creatinine, blood urea nitrogen …
How Do Judgmental Overconfidence and Overoptimism Shape Innovative Activity?
2021
Recent field evidence suggests a positive link between overconfidence and innovative activities. In this paper we argue that the connection between overconfidence and innovation is more complex than the previous literature suggests. In particular, we show theoretically and experimentally that different forms of overconfidence may have opposing effects on innovative activity. While overoptimism is positively associated with innovation, judgmental overconfidence is negatively linked to innovation. Our results indicate that future research is well advised to take into account that the relationship between innovation and overconfidence may crucially depend on what type of overconfidence is most…
Dolores Pareja de Vicente y Juan Olivencia (2018). Interculturalidad y cultura de la diversidad en el contexto universitario.
2021
O mundo de hoje, e caraterizado por uma presenca acrescida de pessoas culturalmente diferentes. Tambem nos nossos contextos educativos e, nomeadamente no ensino superior, podemos verificar este fenomeno. A Universidade e o espaco privilegiado onde se desenvolvem contatos, interacoes, aprendizagens e relacoes com modos de agir, pensar e estar diferentes. O livro Interculturalidad y cultura de la diversidade en el contexto universitario surge no âmbito de um Projeto de inovacao educativa da Universidade de Malaga e tem como proposito presentear-nos com uma reflexao pedagogica, critica e reflexiva sobre a diversidade cultural, a formacao intercultural dos futuros profissionais de educacao e co…
Effects of balance training on functionality, ankle instability, and dynamic balance outcomes in people with chronic ankle instability: Systematic re…
2021
Aim: To identify the effects of balance and strength training on function, ankle instability and dynamic balance in people with chronic ankle instability. Method: The search was conducted on randomized controlled trials that investigated the effects of balance training or strength training in people with chronic ankle instability compared to a control group. Therefore, a systematic electronic search was performed until April 2021 in Pubmed/MEDLINE, Cochrane, and Embase databases. Moreover, an additional search was further performed checking the reference lists of the selected articles. The main outcomes were ankle instability, functionality, and dynamic balance. Finally, a qualitative and q…
false
2021
Young children’s digital media use and physical activity have gained attention in recent research. Parental co-participation has a major impact on children’s health consequences. This study addressed a gap in the research by investigating daily parental co-participation in children’s digital media use and physical play, using the family ecological model theoretical framework. The participants in this nationally representative cross-sectional study were 2512 Finnish parents with two- to six-year-old children. Parents completed a questionnaire. Sociodemographic correlates of co-participation and of the awareness of guidelines regarding co-participation and correlation between co-participation…
El debat sobre l'estructura causal de la teoria evolutiva: lleis, forces i analogies
2021
Resum: Aquest article analitza l’estructura de la teoria evolutiva i les discussions produides als seu voltant en les ultimes decades. En primer lloc, presente l’anomenada “interpretacio de forces” o “analogia newtoniana” i la seua estructura basada en l’elaboracio de tres lleis fonamentals. Mes endavant, mostre les critiques a aquesta interpretacio per diferents autors, en especial l’anomenada “versio estadistica” de la teoria evolutiva. Posteriorment, analitze la idoneitat de la interpretacio de forces i elabore una reformulacio de la mateixa que permet explicar el seu sorgiment i la seua utilitat dins de la literatura biologica. Abstract: This article analyses the structure of evolutiona…
Galiana: història d’un falcó
2021
Resum: En 1365 va tenir lloc una disputa davant la cort del governador de Mallorca per la propietat d’un falcó entre els donzells Berenguer de Galiana i Bernat Togores, en la qual es veu involucrat l’ensinistrador d’aus de caça Bernat Llemosí. Els testimonis que foren presentats per aclarir els fets permeten obtenir una informació molt valuosa, i en part inèdita, del que fou la pràctica d’aquesta art venatòria en el context de les illes Balears, i per extensió en l’Occident europeu. En aquest treball proposem una edició completa del document i en fem un estudi exhaustiu.
 Paraules clau: falconeria, Mallorca, governació, caça Abstract: In 1365 a lawsuit between the noblemen Berenguer of…