showing 36 of ~574560 from 574555 documents
Machine Learning-Based Approach Highlights the Use of a Genomic Variant Profile for Precision Medicine in Ovarian Failure
2021
Ovarian failure (OF) is a common cause of infertility usually diagnosed as idiopathic, with genetic causes accounting for 10–25% of cases. Whole-exome sequencing (WES) may enable identifying contributing genes and variant profiles to stratify the population into subtypes of OF. This study sought to identify a blood-based gene variant profile using accumulation of rare variants to promote precision medicine in fertility preservation programs. A case–control (n = 118, n = 32, respectively) WES study was performed in which only non-synonymous rare variants <
Confinement inside a Crystalline Sponge Induces Pyrrole To Form N−H⋅⋅⋅π Bonded Tetramers
2021
Based on the DFT‐level calculated molecular volume (V mol ) of pyrrole and its liquid density, pyrrole manifests the highest liquid density coefficient LD c (defined as [V mol • density • 0.6023]/FW) value of 0.7. Normal liquids have LD c < 0.63. This very high LD c is due to the strong N‐H … π interactions in solution and hence pyrrole can be considered to be a pseudo‐crystalline liquid. When trapped inside the confined space of the crystalline sponge a reorientation of the N‐H … π interaction is observed leading to specific cyclic N‐H … π tetramers and N‐H … π dimers, verified by single crystal X‐ray crystallographic and computational methods. These tetramers are of the same size as four …
Climate indices in historical climate reconstructions: a global state of the art
2021
Narrative evidence contained within historical documents and inscriptions provides an important record of climate variability for periods prior to the onset of systematic meteorological data collection. A common approach used by historical climatologists to convert such qualitative information into continuous quantitative proxy data is through the generation of ordinal-scale climate indices. There is, however, considerable variability in the types of phenomena reconstructed using an index approach and the practice of index development in different parts of the world. This review, written by members of the PAGES (Past Global Changes) CRIAS working group – a collective of climate historians a…
Etiological factors commonly related to the need of endodontic treatment in individuals with orofacial clefts
2021
Background Dental treatment is fundamental in the rehabilitation of individuals with orofacial clefts, due to their oral condition; when indicated, endodontic therapy allows elimination of infection of the root canal system. Aim: To analyze, by a retrospective study, the most prevalent type of orofacial cleft, the etiological factors most commonly related to the endodontic treatment need, as well as their success and failure rates. Material and methods This study analyzed data from 136 records (76 females and 60 males) with mean age of 19 years and 7 months, who met the inclusion criteria. Data were collected including the type of cleft, etiological factors that led to the need of endodonti…
The Case of Insertional Adductor Tendinopathy of an International-Level 3,000-m Steeplechase Runner
2021
Background: Groin pain is a frequent condition among athletes. One of the causes of groin pain is tendinopathy, a frequently diagnosed medical condition, which can also occur in the adductor muscles. Despite the high prevalence of this medical condition among athletes, it is infrequent to observe tendinopathic groin pain in steeplechase runners. The aim of this case study is to describe the case of an international-level 3,000-m steeplechase runner with groin pain, who was subsequently diagnosed with adductor insertional tendinopathy.Case Presentation: We present the case of an Italian 3,000-m steeplechase and long distance runner, Ala Zoghlami (180 cm, 57 kg), with groin pain, diagnosed as…
Palermo collaborativa
2021
La città di Palermo ha una vocazione multiculturale ed è luogo dell’integrazione e dell’accoglienza. Questa sua caratteristica è confermata dalla partecipazione attiva e propositiva alla redazione della “Carta di Palermo” del 2015 sui temi della mobilità umana internazionale da parte di numerose organizzazioni non governative e realtà associative, accanto alle istituzioni pubbliche. Palermo, come modello positivo di contaminazione culturale e di città collaborativa, lancia la proposta di andare oltre il permesso di soggiorno per approdare al concetto di “cittadinanza di residenza”, riconoscendo il diritto alla mobilità come diritto della persona umana. La migrazione non deve essere consider…
Influence of photo-oxidation on the performance and soil degradation of oxo- and biodegradable polymer-based items for agricultural applications
2021
Abstract The examination of the aging behavior of polymers, blends, composites, items, etc. under different environmental conditions is a priority issue for assessing the possible applications and establishing the lifetime. In agriculture, plastic items (mulch films, irrigation tubes, etc.) are widely used and subjected to solar UV exposure that can induce photo-oxidation on macromolecular chains. Therefore, weathering under outdoor conditions and accelerated degradation tests are performed for simulating aging processes during the lifetime of materials and select appropriate stabilizers to be used. In the last decades, oxo- and biodegradable polymers have been investigated and used in agri…
Correspondence re Piombino-Mascali et al on Mummy Research, Ethics and Editorial Comments
2021
Assessing the impact of COVID-19 on liver cancer management (CERO-19)
2021
[Background & Aims] The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems and it may have heavily impacted patients with liver cancer (LC). Herein, we evaluated whether the schedule of LC screening or procedures has been interrupted or delayed because of the COVID-19 pandemic.
Conceptual Explorations around “Politics”
2021
Abstract This article discusses the ways of conceptualizing politics in parliamentary debates. When the politics-vocabulary is ubiquitous in them, which kind of speech act lies in emphasizing the political aspect? Focusing on thematized uses allows us to identify conceptual revisions in the politics-vocabulary in digitalized plenary debates of the German Bundestag from 1949 to 2017. My fourfold scheme for conceptualizing politics (polity, policy, politicization, politicking) provides the analytical apparatus. The units of analysis in this study are compound words around politics written as single words, a German language specialty. Their frequency has remarkably risen in the Bundestag debat…
Fertility concerns among young breast cancer survivors in Côte d’Or
2021
Introduction Les effets secondaires des traitements utilises dans la prise en charge du cancer du sein (CS) sur la fonction ovarienne et la fertilite ont largement ete documentes. Cependant, les donnees populationnelles sur les difficultes liees a la fertilite des survivantes jeunes apres un CS sont rares et peu d’etudes ont ete realisees sur cette thematique en France. Cette etude visait a decrire les conditions de vie a long terme, en termes de fertilite, des survivantes jeunes apres un CS en Cote d’Or. Methodes Les femmes âgees de 45 ans et moins au diagnostic d’un CS non metastatique entre 2006 et 2015, ont ete selectionnees a partir du Registre des CS et autres cancers gynecologiques d…
L’impact du leadership participatif sur la réduction de l’incertitude et la satisfaction des besoins psychologiques des conseillers de Pôle Emploi
2021
Resume Cette etude examine dans quelle mesure l’impact du leadership participatif sur les emotions et sur la satisfaction des besoins psychologiques est mediatise par une reduction de l’incertitude chez les collaborateurs. Parmi les conseillers a Pole Emploi, 108 ont ete interroges sur leurs perceptions de leadership, leurs incertitudes (i.e. ambiguite de role, besoin de cloture) et sur des indicateurs d’un fonctionnement psychologique satisfaisant au travail (i.e. emotions et satisfaction/frustration des besoins). Les resultats revelent que seul un leadership participatif est associe positivement a nos indicateurs de fonctionnement psychologique au travail et que cette relation est mediati…
MUC16 Is Overexpressed in Idiopathic Pulmonary Fibrosis and Induces Fibrotic Responses Mediated by Transforming Growth Factor-β1 Canonical Pathway
2021
Several transmembrane mucins have demonstrated that they contribute intracellularly to induce fibrotic processes. The extracellular domain of MUC16 is considered as a biomarker for disease progression and death in IPF patients. However, there is no evidence regarding the signalling capabilities of MUC16 that contribute to IPF development. Here, we demonstrate that MUC16 was overexpressed in the lung tissue of IPF patients (n = 20) compared with healthy subjects (n = 17) and localised in fibroblasts and hyperplastic alveolar type II cells. Repression of MUC16 expression by siRNA-MUC16 transfection inhibited the TGF-β1-induced fibrotic processes such as mesenchymal/ myofibroblast transformati…
Morbidity and mortality after anaesthesia in early life:results of the European prospective multicentre observational study, neonate and children aud…
2021
Background: Neonates and infants requiring anaesthesia are at risk of physiological instability and complications, but triggers for peri-anaesthetic interventions and associations with subsequent outcome are unknown. Methods: This prospective, observational study recruited patients up to 60 weeks' postmenstrual age undergoing anaesthesia for surgical or diagnostic procedures from 165 centres in 31 European countries between March 2016 and January 2017. The primary aim was to identify thresholds of pre-determined physiological variables that triggered a medical intervention. The secondary aims were to evaluate morbidities, mortality at 30 and 90 days, or both, and associations with critical …
Patrimonio e progetto
2021
I siti archeologici costituiscono un territorio d’elezione per l’architettura, che si rivela indispensabile per la loro fruizione e salvaguardia. Di fatto, ogni sistema archeologico necessità, oltre che di scavi, di rilievi, di progetti e di molte altre competenze che implicano buona parte dei settori scientifico-disciplinari della cosiddetta area scientifica CUN 08a. La naturale relazione tra architettura e archeologia però, nella realtà dei fatti e al di là di una casistica nota, si scontra con una quotidianità dove con costanza i due ambiti tendono ad avere pochi punti di contatto. Tale distanza trova alimento, in prima battuta, nel sistema di vincoli esistenti che tende a escludere qual…
Omitting axillary lymph node dissection after positive sentinel lymph node in the post-Z0011 era: Compliance with NCCN and ASCO clinical guidelines a…
2021
Summary Purpose In the ACOSOG Z0011 trial, patients with primary breast cancer and 1–2 tumor-involved sentinel lymph nodes (SLNs) undergoing breast-conserving surgery had no oncological outcome benefit after axillary lymph node dissection (ALND), despite a relevant rate of non-SLN metastases of 27%. According to the St Gallen expert consensus, and NCCN and ASCO clinical guidelines, ALND may be avoided in patients who meet all ACOSOG Z0011 inclusion criteria. This recommendation can also be extended to patients undergoing mastectomy, with 1 or 2 positive SLNs and an indication for chest wall radiation, in whom axillary radiotherapy can be proposed as an alternative to completion ALND. The ai…
La introducción de discurso directo por medio del aproximador como en el español de Chile
2021
espanolEn la ultima decada, diversos estudios han dado cuenta de la polifuncionalidad de la particula como en el espanol. Mas alla de su valor semantico aproximador, se ha establecido que como se presenta en el discurso cumpliendo ademas funciones pragmatico-discursivas, como retardacion, atenuacion e introduccion de discurso directo (Holmvik 2011; Jorgensen 2012; Panussis 2016; Mondaca 2017; Panussis y San Martin 2017, Mondaca 2019). En el presente articulo se busca analizar, por una parte, la relacion que existe entre el uso aproximador de como y su funcion de introductor de discurso directo en el espanol de Chile, con el fin de establecer que tipos de informacion son introducidos en esti…
Causes and consequences of DNA damage-induced autophagy.
2021
Abstract Autophagy is a quality control pathway that maintains cellular homeostasis by recycling surplus and dysregulated cell organelles. Identification of selective autophagy receptors demonstrated the existence of pathways that selectively degrade organelles, protein aggregates or pathogens. Interestingly, different types of DNA damage can induce autophagy and autophagy-deficiency leads to genomic instability. Recent studies provided first insights into the pathways that connect autophagy with the DNA damage response. However, the physiological role of autophagy and the identity of its targets after DNA damage remain enigmatic. In this review, we summarize recent literature on the target…
Prefazione a: Amo, ergo sum
2021
The preface to the volume: Amo ergo sum, focuses on the concept of cosmic love present in all the literary production of Nikiforos Vrettakos
Basic Conditions of Adoption Regarding the Person of the Adopted
2021
Abstract At the level of society, adoption is a sensitive phenomenon, through the emotional burden it implies both on the adoptee and on the adoptive person or family. In domestic law, the legal regulation of adoption took different forms, all being influenced by the state of society at a certain moment and has evolved in close accordance with the international regulations in the field, having the form of the procedure regulated by the current normative framework, the legislator showing constant concern to create a legal framework that protects the rights and best interests of the child.
Dorsal Root Ganglion Stimulation for Chronic Postoperative Pain Following Thoracic Surgery: A Pilot Study.
2021
Objectives Post-thoracotomy pain syndrome (PTPS) is defined as persistent pain following a thoracotomy and has an incidence of 21-61%. Dorsal root ganglion stimulation (DRG-S) is a form of neuromodulation that modulates pain signal transmission to the spinal cord. The aims of this study were to investigate the efficacy of DRG-S for the management of PTPS and to assess the role of thoracic paravertebral blocks (t-PVB) as a tool for prediction of success of DRG-S. Materials and methods In this prospective study, we included all patients undergoing thoracic surgery, with PTPS not responding to pharmacotherapy and treated with DRG-S from September 2018 to February 2019. t-PVB followed by a perc…
Slow pyrolysis of an LDPE/PP mixture: Kinetics and process performance
2021
Abstract High- and low-density polyethylene (HDPE and LDPE) and polypropylene (PP) are the most common polymers among plastic waste as they have multiple commercial applications. This study focused on thermal degradation characteristics and kinetic of a plastic mixture with a composition of 92.5 wt% LDPE and 7.5% PP. Thermal decomposition characteristics of the plastic mixture was analysed through thermo-gravimetric analysis (TGA). The overall kinetic of the process was studied using the modified Coats−Redfern method and the Ozawa-Flynn-Wall (OFW) method. The apparent activation energy (E) and pre-exponential factor (A) obtained were 316.0 kJ/mol; 8.09E+21 min−1 and 311.5 kJ/mol; 4.35E+21 m…
Ranking of occupational health and safety risks by a multi-criteria perspective: Inclusion of human factors and application of VIKOR
2021
Nowadays, the Occupational Health and Safety (OHS) is more and more recognized as a crucial process to be properly managed and continuously improved by every organization. Primarily addressed to prevent workers’ injuries and diseases, it positively impacts on productivity, competitiveness and reputation as well as it con-tributes to cost savings in general. OHS management is grounded upon the risk assessment results, on the basis of which defining corrective measures to be taken to reduce risks to acceptable values. In this regard, the paper proposes a Multi-Criteria Decision Making (MCDM) based methodology addressed to the occupational risks prioritization. In order to overcome the shortco…
Energy Efficient Optimization for Solar-Powered UAV Communications System
2021
In this work, we explore the energy efficiency optimization for a solar-powered unmanned aerial vehicle (UAV) communications system. We consider a scenario where a number of ground users (GUs) connect with a solar-powered multi-antenna UAV over a wireless link. First, we are able to derive the relations between the uplink data rate and heading angle of UAV and transmission power of GUs. In addition, the harvested energy from solar light is also affected by UAV’s angle. Accordingly, with the objective to maximize the energy efficiency that is related to uplink data rate and energy consumption, we propose to dynamically adjust the UAV trajectory and gesture, by optimizing its velocity, accele…
Zu Ampelius
2021
Loci aliquot Ampeli, rerum Romanarum scriptoris, ad genuinam lectionem restituuntur.
UAV-Aided Multi-Antenna Covert Communication Against Multiple Wardens
2021
In this paper, we propose a UAV-aided covert communication scheme assisted by a multi-antenna jammer to maximize the transmission rate between a ground transmitter and a UAV receiver against several randomly distributed wardens. The transmitter adopts the maximum ratio transmission, while the jammer zero-forces its transmitted signal at the UAV to disturb the monitoring at wardens without interfering the legitimate transmission. First, we analyze the detection performance and derive the optimal threshold for each warden to minimize its detection outage probability (DOP). Then, with the worst situation in which all wardens set their respective optimal thresholds to achieve the minimum global…
A unique view of SARS-CoV-2 through the lens of ORF8 protein
2021
Immune evasion is one of the unique characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) attributed to its ORF8 protein. This protein modulates the adaptive host immunity through down-regulation of MHC-1 (Major Histocompatibility Complex) molecules and innate immune responses by surpassing the host's interferon-mediated antiviral response. To understand the host's immune perspective concerning the ORF8 protein, a comprehensive study of the ORF8 protein and mutations possessed by it have been performed. Chemical and structural properties of ORF8 proteins from different hosts, such as human, bat, and pangolin, suggest that the ORF8 of SARS-CoV-2 is much closer to OR…
Le premier e-congrès de la SNFMI, Dijon 2020 : impressions, ressentis et bilans
2021
Higher genera Catalan numbers and Hirota equations for extended nonlinear Schrödinger hierarchy
2021
We consider the Dubrovin--Frobenius manifold of rank $2$ whose genus expansion at a special point controls the enumeration of a higher genera generalization of the Catalan numbers, or, equivalently, the enumeration of maps on surfaces, ribbon graphs, Grothendieck's dessins d'enfants, strictly monotone Hurwitz numbers, or lattice points in the moduli spaces of curves. Liu, Zhang, and Zhou conjectured that the full partition function of this Dubrovin--Frobenius manifold is a tau-function of the extended nonlinear Schr\"odinger hierarchy, an extension of a particular rational reduction of the Kadomtsev--Petviashvili hierarchy. We prove a version of their conjecture specializing the Givental--M…
Hypervisor-assisted dynamic malware analysis
2021
AbstractMalware analysis is a task of utmost importance in cyber-security. Two approaches exist for malware analysis: static and dynamic. Modern malware uses an abundance of techniques to evade both dynamic and static analysis tools. Current dynamic analysis solutions either make modifications to the running malware or use a higher privilege component that does the actual analysis. The former can be easily detected by sophisticated malware while the latter often induces a significant performance overhead. We propose a method that performs malware analysis within the context of the OS itself. Furthermore, the analysis component is camouflaged by a hypervisor, which makes it completely transp…
Johnson-Nyquist Noise Effects in Neutron Electric-Dipole-Moment Experiments
2021
Magnetic Johnson-Nyquist noise (JNN) originating from metal electrodes, used to create a static electric field in neutron electric-dipole-moment (nEDM) experiments, may limit the sensitivity of measurements. We present here the first dedicated study on JNN applied to a large-scale long-measurement-time experiment with the implementation of a co-magnetometry. In this study, we derive surface- and volume-averaged root-mean-square normal noise amplitudes at a certain frequency bandwidth for a cylindrical geometry. In addition, we model the source of noise as a finite number of current dipoles and demonstrate a method to simulate temporal and three-dimensional spatial dependencies of JNN. The c…
Structural assessment of the EU-DEMO WCLL Central Outboard Blanket segment under normal and off-normal operating conditions
2021
Abstract Within the framework of the EUROfusion design activities concerning the EU-DEMO Breeding Blanket (BB) system, a research campaign has been carried out at the University of Palermo with the aim of investigating the structural behaviour of the DEMO Water-Cooled Lithium Lead (WCLL) Central Outboard Blanket (COB) segment. The assessment has been performed considering three different loading scenarios: the Normal Operation (NO), the Over-Pressurization (OP) and the Upward Vertical Displacement Event (VDE-up). In particular, NO scenario represents the loading case referring to the nominal operating conditions, whereas the OP scenario refers to the loading conditions due to an in-box LOCA…
Development and Preliminary Validation of a Sport-Specific Self-Report Measure of Identity Foreclosure
2021
A sport-specific, self-report measure of identity foreclosure was developed through a systematic process that included item pool generation, expert review, administration of items to a development sample of intercollegiate student athletes (N = 326), item evaluation, and administration of scales to validation samples of intercollegiate student athletes (N = 322, N = 54, and N = 64, respectively). The process yielded two four-item scales reflecting commitment to the occupational identity of athlete and one 4-item scale reflecting active exploration of roles other than that of athlete that (a) are internally consistent and temporally stable, (b) demonstrate preliminary factorial and convergen…
X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis
2021
Background & aims: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually dimorphic complex autoimmune disease. Methods: We performed a chrX-wide association study, including genotype data from 5 genome-wide association studies (from Italy, United Kingdom, Canada, China, and Japan; 5244 case patients and 11,875 control individuals). Results: Single-marker association analyses found approximately 100 loci displaying P < 5 × 10-4, with the most significant being a signal within the OTUD5 gene (rs3027490; P = 4.80 × 10-6; odds…
Prototipi di nuove centralità
2021
Le nuove centralità sono le grandi aree funzio- nali individuate dallo schema di massima del Piano Regolatore Generale di Palermo per il 2025, opzionate in base al Piano strategico del- la città che le individua come punti di forza del sistema urbano rispetto al contesto regionale. Individuano le aree nelle quali sono localizzati i servizi di rango elevato che fanno della città un polo gravitazionale rispetto al suo ambito metropolitano. La loro funzione si dispiega anche a livello urbano, potenziando, rifunzio- nalizzando, o rilocalizzando, attività di servizio a scala urbana e sovralocale.
Novel SCNN1A gene splicing-site mutation causing autosomal recessive pseudohypoaldosteronism type 1 (PHA1) in two Italian patients belonging to the s…
2021
Abstract Introduction Pseudohypoaldosteronism type 1 (PHA1) is a rare genetic disease due to the peripheral resistance to aldosterone. Its clinical spectrum includes neonatal salt loss syndrome with hyponatremia and hypochloraemia, hyperkalemia, metabolic acidosis and increased plasmatic levels of aldosterone. Two genetically distinct forms of disease, renal and systemic, have been described, showing a wide clinical expressivity. Mutations in the genes encoding for the subunits of the epithelial sodium channels (ENaC) are responsible for generalized PHA1. Patients’ presentation We hereby report on two Italian patients with generalized PHA1, coming from the same small town in the center of S…