showing 36 of ~574560 from 574555 documents
Dense drug-eluting biodegradable Fe-Ag nanocomposites
2021
Abstract Biodegradable metals in orthopedics are aimed to eliminate secondary the surgical intervention for implant removal, and thus improve patient compliance, reduce surgery costs and the risk of infections. In addition, biodegradable implants could be loaded with different drugs to prevent the growth of pathogens and the development of bone infections, kill remaining cancer cells after tumor resection or stimulate bone regeneration. However, drugs undergo thermal decomposition under the conditions of conventional metal fabrication processes. In this work, we describe the fabrication of a dense drug-eluting biodegradable Fe-Ag nanocomposite containing 10 vol% of Ag and loaded with the an…
The multiple facets of Cajal-Retzius neurons.
2021
ABSTRACTCajal-Retzius neurons (CRs) are among the first-born neurons in the developing cortex of reptiles, birds and mammals, including humans. The peculiarity of CRs lies in the fact they are initially embedded into the immature neuronal network before being almost completely eliminated by cell death at the end of cortical development. CRs are best known for controlling the migration of glutamatergic neurons and the formation of cortical layers through the secretion of the glycoprotein reelin. However, they have been shown to play numerous additional key roles at many steps of cortical development, spanning from patterning and sizing functional areas to synaptogenesis. The use of genetic l…
Hepatitis C virus: Current steps toward elimination in Germany and barriers to reaching the 2030 goal
2021
Abstract Hepatitis C virus (HCV) affects over 70 million people globally, with an estimated 399 000 HCV‐related deaths in 2016. The World Health Organization (WHO) has set a goal to eliminate HCV by 2030. Despite the availability of direct‐acting antivirals—highly effective and well‐tolerated therapies for HCV—many patients infected with HCV in Germany have not initiated treatment, including a majority of those who are aware of their positive diagnosis. Barriers to screening, diagnosis, and treatment are major factors taking many countries off track for HCV elimination by 2030. Identifying country‐specific barriers and challenges, particularly in at‐risk populations such as people who injec…
MOSUNETUZUMAB MONOTHERAPY IN ELDERLY/UNFIT PTS WITH FIRST‐LINE DIFFUSE LARGE B‐CELL LYMPHOMA (DLBCL): SAFETY AND EFFICACY REMAIN PROMISING WITH DURAB…
2021
Field-Grown and In Vitro Propagated Round-Leaved Sundew (Drosera rotundifolia L.) Show Differences in Metabolic Profiles and Biological Activities
2021
Drosera rotundifolia L. is a carnivorous plant used in traditional medicine for its therapeutic properties. Because of its small size, its collection in nature is laborious and different cultivation methods have been studied to ensure availability. However, only a few studies exist where the lab-grown sundew tissue and field-grown sundew would have been compared in their functionality or metabolic profiles. In this study, the antioxidant and antiviral activities of lab-grown and field-grown sundew extracts and their metabolic profiles are examined. The effect of drying methods on the chromatographic profile of the extracts is also shown. Antioxidant activity was significantly higher (5–6 ti…
Hybrid Conflicts Actors’ Action Models Analysis
2021
Abstract The present article highlights the need to understand the physiognomy of hybrid conflicts, the action methodology of the actors in these conflicts, and aims to identify the correlation between the characteristics of the hybrid operational environment and the typology of participating actors in order to model future military actions. The ever-changing nature of the operational environment emphasizes the importance of understanding the military phenomenon in terms of the process of conflict management and resolution, in general, and of the hybrid conflicts in particular.
Content Analysis as a Research Method: A Content Analysis of Content Analyses in Sport Communication
2021
Content analysis is a popular method in communication and media research. However, to what extent and in which contexts it is used in sport communication research has hardly been investigated. In order to provide empirically grounded insight, the authors conducted a quantitative content analysis of scholarly journal articles using content analysis as a research method, focusing on three major international sport communication journals during the 10 years between 2010 and 2019 (N = 267). Results indicate that qualitative and quantitative methods are used equally while combinations with other methods are comparatively rare. The studies cover a broad portfolio of different topics. Social media…
Pera Coscia siciliana di IV gamma, effetti degli edible coating sulla qualità dei frutti
2021
Questo studio ha voluto mettere in evidenza gli effetti dell’edible coating nel tempo, in particolare individuando le differenze nel mantenimento delle caratteristiche fisico-chimiche e sensoriali tra frutti di pero trattati e quelli di controllo. Dall’analisi dei risultati ottenuti è emerso che i trattamenti hanno consentito di ottenere effetti positivi sui parametri qualitativi considerati, permettendo una più lunga conservazione. Infatti, durante la frigoconservazione, i frutti che hanno subito i trattamenti (AVG+HPMC+PEO - EC1 e AVG+HPMC - EC2) hanno mostrato risultati migliori rispetto ai frutti non trattati (CTR), mantenendo, durante i 7 giorni di conservazione, valori più elevati in …
L’inedito antependium d’argento di Salvatore Castronovo a San Mauro Castelverde
2021
Tra i diversi e ricchi Tesori siciliani, indagati a partire dagli anni Trenta del secolo scorso da Maria Accascina, si inserisce quello, pressoché inedito, di San Mauro Castelverde. A conclusione del processo di rinnovamento stilistico che interessò la chiesa di san Mauro del centro madonita nel corso del XVIII secolo, venne commissionato, nel 1778, l’inedito paliotto architettonico in argento, con la figura del Patrono al centro, oggetto di questo studio One of the many rich Sicilian treasures investigated since the 1930s by Maria Accascina is the almost unpublished altarpiece from San Mauro Castelverde. At the end of the process of stylistic renovation that affected the church of San Maur…
#patientstoo - Professional sexual misconduct by healthcare professionals towards patients: a representative study.
2021
Abstract Aims Sexual border violations are a severe problem in the healthcare system. Studies using non-probability samples indicate a high prevalence of professional sexual misconduct (PSM) towards patients. However, valid prevalence rates are lacking. Methods We did a cross-sectional, observational study in Germany from February to April 2020. By different sampling steps, a probability sample of the German population above the age of 14 was generated. The final sample consisted 2503 persons (50.2% female, mean age: 49.5 years). Participants were asked about sexual contacts with and sexual harassment by healthcare professionals. Using descriptive statistics, prevalence rates of PSM were es…
Amphibians and reptiles as palaeonvironmental proxies during the Late Pleistocene (MIS3): The case of Stratigraphic Unit V of El Salt, Alcoi, Spain
2021
The locality of El Salt (Alcoi, Spain) is a key site for understanding the extirpation of Neanderthals in the eastern part of Iberia. In this paper, we analyse an assemblage of amphibians and reptiles from Stratigraphic Unit V (45.2 ± 3.4 ka to 44.7 ± 3.4 ka), which corresponds to one of the last regional records of Neanderthals, to improve knowledge of the palaeoecology and palaeoclimate of this event. The assemblage comprises three anurans (Pelodytes sp., Alytes obstetricans, and Epidalea calamita), two lizards (Lacertidae indet. and Chalcides bedriagai), and five snakes (Colubridae indet., Coronella sp., Coronella sp./Zamenis sp., Natrix maura, and Vipera latastei). Palaeoclimatic recons…
Root architectural traits of rooted cuttings of two fig cultivars: Treatments with arbuscular mycorrhizal fungi formulation
2021
Abstract Many fruit tree species develop symbioses relationships with mycorrhizal fungi by which they improve their efficiency in water and nutrient uptake and, in turn, increase their vegetative growth and productivity, particularly under stressful environments. These benefits origin from the effects that mycorrhizal determined on the root architecture, morphology and physiology. Usually, few attentions has been devoted to the tree root structure and function, especially, in fig plants during their growth phase in the nursery. Recently, several root traits or phenes have been reported as fundamental for the root functions such as the root length ratio (plant’s potential for the exploitatio…
Fit-for-Discharge Criteria after Esophagectomy: An International Expert Delphi Consensus
2021
Summary There are no internationally recognized criteria available to determine preparedness for hospital discharge after esophagectomy. This study aims to achieve international consensus using Delphi methodology. The expert panel consisted of 40 esophageal surgeons spanning 16 countries and 4 continents. During a 3-round, web-based Delphi process, experts voted for discharge criteria using 5-point Likert scales. Data were analyzed using descriptive statistics. Consensus was reached if agreement was ≥75% in round 3. Consensus was achieved for the following basic criteria: nutritional requirements are met by oral intake of at least liquids with optional supplementary nutrition via jejunal fe…
The use of vineyard spectral signatures to identify table grape cultivars
2021
Vineyards have characteristic responses to sunlight. The reflectance values at the different wavelengths are typical of vegetation and define its spectral signature. The aim of this work was to determine the spectral signatures of table grape vineyards located in the production area of Robinvale (Victoria, Australia) in order to identify cultivars in the vineyard. Spectral signatures were detected from images in eight bands from the Worldview 3 platform. Spectral signatures for a representative number of plots were extracted using satellite reflectance images for each cultivar. Spectral signatures were also collected in the field, from the same cultivars, with a FieldSpec® HandHeld 2 portab…
Type 1A endoleak detachable coil embolization after endovascular aneurysm sealing: Case report
2021
Introduction Endovascular aneurysm sealing (EVAS) with the Nellix system was introduced to reduce endovascular aneurysm repair (EVAR) perioperative complications, especially endoleaks. Herein we report a case of successful type 1A endoleak managed with detachable coils embolization after EVAS. Presentation of case A 77-year-old male was referred for abdominal pain. The angio-CT scan confirmed the previous EVAS procedure and showed a type Is2 endoleak below the right renal artery resulting in a 2.5 cm aortic blister with contrast medium filling the space between the aortic wall and the endobags. The patient was considered unfit for conventional open surgery and an endovascular approach with …
Informal caregiving and work: A high price to pay. The case of Baltic States
2021
Abstract The impact of informal care burden on the labour market outcomes has been the subject of a number of studies. The literature so far has, however, mostly neglected the post-transition countries. The purpose of this study is to provide empirical evidence on various labour market implications of informal care in the three Baltic States – Estonia, Latvia and Lithuania. In particular, we examine the extensive and intensive margins of work, wage effects, job seeking behaviour and utilization of unemployment benefits. We apply instrumental variable approach to address the observed endogeneity of informal care. The obtained results support the existence of a significant deterrent effect of…
Electrochemical production and use of chlorinated oxidants for the treatment of wastewater contaminated by organic pollutants and disinfection
2021
Abstract In the last years, an increasing attention has been devoted to the use of electrogenerated chlorinated oxidants for the treatment of wastewater polluted by recalcitrant organics and/or for the disinfection of water contaminated by pathogen microorganisms. In this review, more recent and relevant findings were presented and critically discussed. The main advantages and disadvantages of this technique were commented, including the potential formation of toxic chlorinated organic specie and of chlorate and perchlorate or the difficult selection of proper operative parameters, as well as the key points that should be addressed to enhance the use on an applicative scale.
The Expanding Spectrum of Mutations in Hereditary Angioedema.
2021
The evolution in the knowledge of rare genetic diseases such as hereditary angioedema (HAE) has increased at a parallel pace with the development of new molecular tools. The deficiency of C1 inhibitor (C1-INH) has been recognized as the main cause of HAE (HAE-C1-INH) since the 1960s, but the discovery of the wide spectrum of mutations affecting the C1-INH gene (SERPING1) was possible only from the late 1980s, when Sanger sequencing became available and more accessible worldwide. Nevertheless, the involvement of other genes in HAE was discovered only in 2006 with the description of mutations in the F12 gene in patients with HAE and normal C1-INH. In the last 3 years, advanced next-generation…
BUCKLEY, Nicolás, Del sacrificio a la derrota. Historia del conflicto vasco a través de las emociones de los militantes de ETA, Siglo XXI, Madrid, 20…
2021
Learning With Context Feedback Loop for Robust Medical Image Segmentation
2021
Deep learning has successfully been leveraged for medical image segmentation. It employs convolutional neural networks (CNN) to learn distinctive image features from a defined pixel-wise objective function. However, this approach can lead to less output pixel interdependence producing incomplete and unrealistic segmentation results. In this paper, we present a fully automatic deep learning method for robust medical image segmentation by formulating the segmentation problem as a recurrent framework using two systems. The first one is a forward system of an encoder-decoder CNN that predicts the segmentation result from the input image. The predicted probabilistic output of the forward system …
Healthcare for Older Adults, Where Are We Moving towards?
2021
Since the end of World War II, science has not stopped progressing [...]
Acceptance of SARS-CoV-2 Vaccination Among a Cohort of IBD Patients From Southern Italy: A Cross-Sectional Survey
2021
La distribución espacial de hogares perceptores de prestaciones económicas individualizadas: una comparación de casos
2021
El análisis de las desigualdades socioespaciales ha constituido una línea de investigación destacada en el ámbito de las ciencias sociales. No obstante, la cuestión de la desigual proyección territorial de las políticas sociales en el interior de las ciudades ha recibido una menor atención académica. En este artículo se analizan, desde una perspectiva comparada, los patrones de distribución espacial de los hogares perceptores de Prestaciones Económicas Individualizadas (PEI) en dos municipios de la Comunidad Valenciana (España): Bétera y Torrent. Para ello, se implementan distintas técnicas de análisis de puntos espaciales y de Análisis Exploratorio de Datos Espaciales (AEDE). Los resultado…
What is the optimal treatment for T1N0 anal squamous cell carcinoma? Analysis of current practices in the prospective French FFCD ANABASE cohort
2021
International audience; Introduction: for localized T1N0 squamous cell carcinoma of the anus (SCCA) standard radiotherapy (RT) may result in overtreatment and alternative strategies are debated. Methods: T1N0M0 SCCA treated between 2015 and 2020 by local excision (LE) or RT were analyzed from the French prospective FFCD ANABASE cohort. Treatment strategies, recurrence-free and colostomy-free survivals (RFS, CFS) and prognostic factors were reported. Results: among 1135 SCCA patients, 99 T1N0M0 were treated by LE(n = 17,17.2%), or RT ( n = 82,82.8%) including RT alone ( n = 65,79.2%) or chemo-RT ( n = 17, 20.7%). Median follow-up was 27.2 months [0.03 and ndash;54.44]. Median tumor size were…
Angioedema Coexisting Chronic Spontaneous Urticaria Negatively Influences Patients’ Sense of Coherence, What Results in Susceptibility to Anxiety Sym…
2021
Background: Angioedema coexisting chronic spontaneous urticaria (CSU) is proved to result in patient anxiety occurrence, but the mechanisms and susceptibility patterns are unknown. Sense of coherence (SOC) is one of methods of coping with stress and is defined as a person’s general orientation toward life. We decided to assess SOC disturbances in CSU patients in the context of possible angioedema association. Methods: The study comprised 71 CSU subjects. To analyze disease activity, the Urticaria Activity Score seven-day assessment questionnaire (UAS7) was used. For anxiety assessment, the STAI questionnaire was used. The SOC-29 questionnaire, consisting of questions related to comprehensib…
Correspondence re Piombino-Mascali et al on Mummy Research, Ethics and Editorial Comments
2021
Iron operates as an important factor promoting year-round diazotrophic cyanobacteria blooms in eutrophic reservoirs in the tropics
2021
Abstract We hypothesize that iron availability plays an important role in driving phytoplankton structure and dynamics in tropical reservoir. This role has often been neglected in routine monitoring of water quality since the main focus has been addressed on macronutrients such phosphorus and nitrogen. To elucidate the potential regulation exerted by iron availability on phytoplankton, a limnological investigation was carried out in two neighboring eutrophic reservoirs in tropical China. Traditional physical and chemical variables were measured along with total and dissolved iron concentrations to explore how they could influence phytoplankton structure. Statistical analyses showed that dis…
Use of microbial biostimulants to increase the salinity tolerance of vegetable transplants
2021
Vegetable plants are more sensitive to salt stress during the early growth stages
Data mining, dashboards and statistics: a powerful framework for the chemical design of molecular nanomagnets
2021
Abstract Three decades of intensive research in molecular nanomagnets have brought the magnetic memory in molecules from liquid helium to liquid nitrogen temperature. The enhancement of this operational temperature relies on a wise choice of the magnetic ion and the coordination environment. However, serendipity, oversimplified theories and chemical intuition have played the main role. In order to establish a powerful framework for statistically driven chemical design, we collected chemical and physical data for lanthanide-based nanomagnets to create a catalogue of over 1400 published experiments, developed an interactive dashboard (SIMDAVIS) to visualise the dataset, and applied inferentia…
Flavonoids against the SARS-CoV-2 induced inflammatory storm
2021
The disease severity of COVID-19, especially in the elderly and patients with co-morbidities, is characterized by hypercytokinemia, an exaggerated immune response associated with an uncontrolled and excessive release of proinflammatory cytokine mediators (cytokine storm). Flavonoids, important secondary metabolites of plants, have long been studied as therapeutic interventions in inflammatory diseases due to their cytokine-modulatory effects. In this review, we discuss the potential role of flavonoids in the modulation of signaling pathways that are crucial for COVID-19 disease, particularly those related to inflammation and immunity. The immunomodulatory ability of flavonoids, carried out …
Prototipi di nuove centralità
2021
Le nuove centralità sono le grandi aree funzio- nali individuate dallo schema di massima del Piano Regolatore Generale di Palermo per il 2025, opzionate in base al Piano strategico del- la città che le individua come punti di forza del sistema urbano rispetto al contesto regionale. Individuano le aree nelle quali sono localizzati i servizi di rango elevato che fanno della città un polo gravitazionale rispetto al suo ambito metropolitano. La loro funzione si dispiega anche a livello urbano, potenziando, rifunzio- nalizzando, o rilocalizzando, attività di servizio a scala urbana e sovralocale.
Electronic government and corruption: Systematic literature review, framework, and agenda for future research
2021
Abstract The notion of corruption has emerged as a prominent topic against the backdrop of e-government. However, there are diverse but disorganized viewpoints about the relationship between e-government and corruption, thus creating difficulties in obtaining a structured overview of the existing literature and identifying the avenues to take this research area forward. Despite this, prior studies have made limited attempts to gather these fragmented observations to guide future research holistically. To address this concern, we conduct a systematic literature review (SLR) of 63 articles discussing e-government and corruption and provide a comprehensive synthesis of the current knowledge in…
Agro-hydrological models and field measurements to assess the water status of a citrus orchard irrigated with micro-sprinkler and subsurface drip sys…
2021
Compared to the micro-sprinkler irrigation, traditionally used in citrus orchards, subsurface drip systems (SDS) allow increasing the water use efficiency (WUE); when coupled with water-saving strategies, like regulated deficit irrigation (RDI), further increase of WUE are possible. Combining measurements of soil water content (SWC) and weather data with measurements of midday stem water potential (MSWP) makes it possible to identify irrigation scheduling parameters for the RDI. However, measurements of MSWP are destructive and time-consuming, and also require skilled operators. For all these reasons, the use of the agro-hydrological models, such as the FAO-56 model, can be considered a sur…
A heterozygous mutation in the RAG2 gene with cutaneous and systemic manifestations partially resembling Omenn syndrome
2021
Role of JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular Mechanisms
2021
Interstitial lung diseases (ILDs) comprise different fibrotic lung disorders characterized by cellular proliferation, interstitial inflammation, and fibrosis. The JAK/STAT molecular pathway is activated under the interaction of a broad number of profibrotic/pro-inflammatory cytokines, such as IL-6, IL-11, and IL-13, among others, which are increased in different ILDs. Similarly, several growth factors over-expressed in ILDs, such as platelet-derived growth factor (PDGF), transforming growth factor β1 (TGF-β1), and fibroblast growth factor (FGF) activate JAK/STAT by canonical or non-canonical pathways, which indicates a predominant role of JAK/STAT in ILDs. Between the different JAK/STAT iso…
Anaerobic Degradation of Environmentally Hazardous Aquatic Plant Pistia stratiotes and Soluble Cu(II) Detoxification by Methanogenic Granular Microbi…
2021
The aquatic plant Pistia stratiotes L. is environmentally hazardous and requires effective methods for its utilization. The harmfulness of these plants is determined by their excessive growth in water bodies and degradation of local aquatic ecosystems. Mechanical removal of these plants is widespread but requires fairly resource-intensive technology. However, these aquatic plants are polymer-containing substrates and have a great potential for conversion into bioenergy. The aim of the work was to determine the main patterns of Pistia stratiotes L. degradation via granular microbial preparation (GMP) to obtain biomethane gas while simultaneously detoxifying toxic copper compounds. The compos…