ABDOMINAL DESMOID TUMORS: A CASE REPORT ANATOMICAL ASPECT

Desmoid tumors are rare neoplasms of the soft tissues which develop from fibrous tissues and are histologically characterized by fibroblastic proliferation. They tend to recur at the local site of a previous condition and they do not metastasize. The general clinical presentations manage to simulate the malignant neoplasia from the same histological group. The authors have may have these tumors in the local area on the abdominal wall which can be treated by a large surgical cut in order to avoid recurrence.

DESMOID TUMOR: ANATOMICAL STUDY AND REVIEW OF THE LITERATURE

CAPSAICIN STIMULATION AND NEUROGENIC EXPERIMENTALLY INDUCED INFLAMMATION OF THE HUMAN LABILA MUCOSA

B-Lactam antibiotics in daily dentistry practice: a critical review

Expression of beta endorphin and caspase 9 in orthodontically treated dental pulp

Omega-3 PUFAs and gut microbiota: A preventive approach for colorectal cancer

The influence of diet on the composition of the intestinal microbiota and related pathologies has been known for some time. Some classes of nutrients, such as fatty acids belonging to the omega 3 series, have particular effects on the bacteria that make up the intestinal microbiota. ω-3 PUFAs affect the gut microbiota in three different ways: by modulating the type and abundance of intestinal bacteria, by regulate SCFAs levels, and by alter the levels of proinflammatory mediators. Through these modalities, ω-3 PUFAs could be useful for the prevention of intestinal diseases such as Colorectal Cancer (CRC). The ability of ω-3 PUFAs to modulate the intestinal inflammatory response, to preserve…

Nf-k B as target of Pharmacological Treatment

OBSTRUCTED DEFECATION SYNDROME AND CHRONIC CONSTIPATION: CLINICAL AND SURGICAL ANALYSIS AND PSYCHOLOGICAL IMPLICATIONS

Chronic constipation and Obstructed defecation Syndrome (ODS) represent a high-incidence pathological status that severely compromise of Quality of Life (QoL). Our multidisciplinary study is aimed to investigate how the resolution of ODS by surgical technique can improve long-term clinical symptoms and the state of physical and mental health and QoL, focusing on the dual interaction between psyche and intestine Chronic constipation and Obstructed Defectaion Syndrome represent a high-incidence pathological status that severely compromise of Quality of Life. Our multidisciplinary study is aimed to investigate how the resolution of ODS by surgical technique can improve long-term clinical sympt…

Adipokines in obesity and metabolic diseases

Adipose tissue secretes many adipokines that regulate important physiological functions. Growing studies have highlighted that these bioactive molecules may contribute to the development of metabolic and cardiovascular diseases. Adipokines exert systemic metabolic effects and independent activity on numerous cells of the cardiovascular system, including cardiomyocytes and vascular cell walls. Adiponectin shows anti-inflammatory and anti-atherosclerotic activity on blood vessels. Conversely, resistin is endowed with pro-inflammatory effects and stimulates the proliferation of smooth muscle cells, thus promoting the development of atherosclerotic plaque. Leptin plays an important role in card…

Multiple sclerosis: oral manifestation and dental implications

CAPILLAROSCOPIC AND HISTOLOGIC EXAMINATION OF THEH UMAN LABIAL MUCOSA: A NEW NON-INVASIVE METHODOLOGY COMPARED WITH THE HISTOLOGICA EXAM

EXTRACELLULAR VESCICLES DERIVED FROM GUT MICROBIOTA IN INFLAMMATORY BOWEL DISEASE AND COLORECTAL CANCER

The human gut microbiome encompasses inter alia, the myriad bacterial species that create the optimal host-micro-organism balance essential for normal metabolic and immune function. Various lines of evidence suggest that dys-regulation of the microbiota-host interaction is linked to pathologies such as inflammatory bowel disease (IBD) and colorectal cancer (CRC). Extracellular vesicles (EVs), found in virtually all body fluids and produced by both eukaryotic cells and bacteria are involved in cell-cell communication and crosstalk mechanisms, such as the immune response, barrier function and intestinal flora. This review highlights advancements in knowledge of the functional role that EVs ma…

INFLAMMATORY BOWEL DISEASE AND COLORECTAL CANCER, NUTRACEUTICAL ASPECTS

Nutraceuticals constitute a group of functional foods that provide added health benefits for various disorders including inflammatory bowel disease (IBD) and colorectal cancer (CCR). The main groups of nutraceuticals include probiotics, prebiotics omega 3 and antioxidants. Studies on nutraceutical showed that this type of food possessed similar properties to drugs but with the benefit of not having side effects. This mini review shows that probiotics and prebiotics, when administered simultaneously with traditional therapies, reduce IBD symptoms and reduce synthesis of enzymes probably involved in colorectal carcinogenesis. Moreover, Omega 3 reduces the synthesis of inflammation mediators a…

Preliminary morpho-structural studies during endodontic treatment with Ni-Ti 55-45 instruments

Penphigus Vulgaris in a mediterranean Young Adult Manifesting as Desquamative Gingivitis

THE ELEVATION OF THE MAXILLARY SINUS: OUR CLINICAL EXPERIENCE

ORAL CAPILLAROSCOPIC: a new diagnostic method.

INFLAMMATORY BOWEL DISEASE AND PERIPHERAL ATRHITIS: MESALAZINA AND PROBIOTICS

The inflammaotory bowel disease (IBD) are a group of inflammatory pathologies of the digestive line with chronicity and recurrent characteristic. The IBDs mostly recognized are the ulcerative colitis and Crohn's disease; they are more frequent in the industrialized countries and among the caucasian populations that among those africans or oriental. The secondary artropaties to IBD recognize a multifactorial genesis in subjects predisposed as a result genetically or environmental factors; a fundamental role of the intestinal dysbiosis they are hypothesized.

PANORAMIC PERIODONTAL CAPILLAROSCOPY: A NEW DIAGNOSTIC METOD

PRELIMINARY OBSERVATIONS ABOUT CAPILLAROSCOPIC AND HISTOLOGIC EXAMINATIONS OF THE HUMAN LABIAL MUCOSA

FRATTURA DI IMPIANTI DENTARI: A CASE REPORT

HODKIN'S DISEASE AND ITS ORAL MANIFESTATIONS

CAPILLAROSCOPIC MORPHOFUNCTIONAL MODIFICATIONS DURING SEPSIS

MORPHOLOGICAL MODIFICATIONS OF VENTRICULO PERITONEAL SHUNTS

Analisi morfometrica computerizzata delle variazioni strutturali della diafisi di ossa lunghe umane in rapporto all'età.

The authors studied the micro - structural changes of aging long bones. The results show: an increase in the number of the osteons; a sensible decrease in their sectional area; a disappearance of the outer fundamental system until the sixth decade, which undergoes no significant changes afterwards. Whereas the area of the haversian canals and the percentage of the haversian system undergo no significant changes. The data suggest that the skeletal remodeling tends to keep constant, during the lfetime, the quota of the haversian system and the relation between the latter and the interstital system, through an increase in numebr of the osteons which involves a decrease in their size. On the ot…

[Oral capillaroscopy: a new diagnostic method].

The morphological-functional study of microcirculation is of fundamental importance; in fact, the microvascular bed is directly involved both in autoimmune etiopathogenesis pathologies, and in acute and chronic inflammatory etiopathogenesis pathologies. Oral capillaroscopy is a very stimulating method for studying microcirculation, because of the possibility of studying small vessels in vivo by means of a microscope. Today, it is becoming more reliable thanks to the improvement of the observation tools (photography, videomicroscopy).

EVALUATION OF THE CLINICAL AND HISTOLOGICAL EFFECTIVENESS OF ISOTRETIONIN IN THE THERAPY OF ORAL LEUKOPLAKIA.TEN YEARS OF EXPERIENCE: IS MANAGEMENT STILL UP-TO-DATE AND EFFECTIVE?

Inhalatory anaesthesia Vs. TIVA in oral surgery and laryngectomy with lateral clearing: our experience

Comparative analysis of the structure of temporomandibular joint in human and rabbit.

In order to increase knowledge on the morphology and structure of the articular disc of the temporomandibular joint (TMJ) for a better understanding of the functional role of the same, it proceeded with an investigation on histological samples in the block of TMJ and periarticular tissues of adult rabits and human fatustes at different stage of development. (www.actabiomedica.it)

NUTRITION, OXIDATIVE STRESS AND INTESTINAL DYSBIOSIS: INFLUENCE OF DIET ON GUT MICROBIOTA IN INFLAMMATORY BOWEL DISEASES.

Background: Microbiota refers to the population of microorganisms (bacteria, viruses and fungi) that inhabit the entire gastrointestinal tract, more particularly the colon whose role is to maintain the integrity of the intestinal mucosa and control the proliferation of pathogenic bacteria. Alteration in the composition of the gut microbiota is called dysbiosis. Dysbiosis redisposes to inflammatory bowel diseases such as ulcerative colitis, Crohn disease and indeterminate colitis. Methods: The purpose of this literature review is to elucidate the influence of diet on the composition of the gastrointestinal microbiota in the healthy gut and the role of diet in the development of dysbiosis. Co…

CAPSAICIN STIMULATION AND NEUROGENIC EXPERIMENTALLY INDUCED INFLAMMATION OF THE HUMAN LABIAL MUCOSA

Background. The neurogenic inflammation depends on the neuromodulator release by peripheral nervous termi−nations. A series of different studies proved the existence of a neurogenic phlogosis (NP) in different body sites.Only experiences on rat managed to induce NP at the oral mucosa level.Objectives. Inducing NP at the human mucosa level.Material and Methods. Two groups of patients (group A: M/F: 8/7; mean: 41.14 ± 12.4; range: 24–60; group B:M/F: 8/7; mean: 41.21 ± 12.39; range: 23–60) were examined in authors’ laboratory. The NP was experimentallyinduced at the lower lip mucosa level after topically applying capsaicin. The vascular consequences were observedthrough computer videocapillar…

An unusual case of a partial midgut malrotaion

PRENATAL DEVELOPMENT OF TEMPORO-MANDIBULAR JOINTS: STATE OF ART

The aim of this work is to analyze the state of the art of temporo-mandibular joint (MJ) to understand the varoius stage of the development of the same during embryogenesis. Various theories have been analyzed, such as the formation of apoptotic or the important role of growth factors, or the Valencia et studies in which are analyzed to numerous articular diseases in various stage of development. By the aforementioned studies show that many factors, of a different nature, are to be involved in the prenatal developlment of this important joint.

CANALAR REPROCESSING WITH NI-TI INSTRUMENTS: OUR EXPERIENCE.

Implant fracture. Case report

PRELIMINARY STUDIES OF MICROCIRCULATORY IN SEPSI ITALIAN JOURNAL OF ANATOMY AND EMBRIOLOGY

Caratteristiche capillaroscopiche del microcircolo labiale di pazienti affetti da tiroidite di Hashimoto.

PRELIMINARY TREATMENT ABOUT MODIFICATON OF THE MORPHOLOGY OF THE TEETH DURING ORTHODONTIC TREATMENT

CANALAR REPROCESSING G WITH NI-TI INSTRUMENTS: OUR EXPERIENCE.

Comparative analysis of Hsp10 and Hsp90 in large bowel healthy mucosa and adenocarcinomas

Heat shock proteins (Hsps) are an important class of molecules with various functions. Their classic role is to assist other proteins in folding and re-folding and, when proteins are defective or irreversibly misfolded, to drive their degradation. For this reason, some Hsps are also named molecular chaperones. During evolution, this class of proteins has also acquired extrachaperoning roles such as participation in immune system regulation, cell differentiation, programmed cell death and carcinogenesis. Hsp10 is a partner of Hsp60 in the Hsp60/10 folding machine, but numerous scientific studies have shown that Hsp10 may also play other roles. In fact, Hsp10 seems to have an immunomodulatory…

COULD THE ENDOSCOPIC RESECTION OF A LARGE RECTAL LEIOMYOMA BE AN EFFETCIVE AND SAFE TECHNIQUE?

Summary. Rectal leiomyomas are a rare conditions, with low reported incidence in literature and constitute about 0.1% of rectal tumours; in fact rectal leiomyomas occur in approximately 1 out of 2000-3000 rectal tumors. We report on a patient with a 3 cm semi-pedunculated colonic leiomyoma, which was successfully removed by endoscopic polypectomy after normal saline-epinephrine submucosal injection. When we encounter a tumor during a colonoscopic examination, we usually evaluate the tumor carefully and perform an endoscopic resection when we judge it is appropriate. When a symptomatic smooth muscle tumors smaller than 2 cm are incidentally found on colonoscopy, surgical resection is unneces…

IMMUNOLOGICAL ASPECTS OF CROHN'S DISEASE: A REGULATORY FUNCTION OF TIM-3/GALECTIN-9 IN LYTH1.

Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) and its etiology is multifactorial and involves a combination of genetic environmental factors. The interaction of these factors causes an imbalance of the microbiota, leading to the activation of several immunological and inflammatory mechanism. From an immunological point of view, there seems to be an involvement of the TIM-3/GALECTIN-9 pathway and of the autoregulation of lyTh1. These studies show that in patients with CD the autoregulation of lyth1 is lost due to a reduced concentration of galectin-9 and a reduced TIM-3 expression in LyTh1. This could be one of the reason for the state of perpetual activation of lyTh1, r…

Topical capsaicin application and axon reflex vasodilatation of the tongue: A videocapillaroscopic study

The aim of this study was to evaluate the effects of topical capsaicin application on human lingual mucosa and to assess if neurogenic inflammation might have a role in the pathogenesis of lingual diseases. Thirty patients (16 males and 14 females; mean age: 41.46 +/- 11.8 years; range: 23-60) were examined in our laboratory. The neurogenic inflammation was experimentally induced in the lingual mucosa close to 1) the left margin of the tongue and 2) the right margin of the tongue after ipsilateral nerve trunk anesthesia. The characteristics of lingual microcirculation were observed using computerized videocapillaroscopic techniques. The vasodilatation was observed close to the left margin o…

Expression of β-Endorphin and Caspase-9 in Orthodontically Treated Dental Pulp.

Introduction. For several years, our histology laboratory has worked in co-operation with the Winchmore Hill Dental Practice studying the activity of Acetylcholinesterase and some neuropeptides (CGRP, Sub. P, Enkephalins, Endorphins)(1) in orthodontic treated human dental pulp to clarify force's action. It seems that recent data do not yet, fully elucidate the exact effects of the force applied on teeth. For this reason we are investigating whether the traction is involved in some cases of pulpal death. In this study we focused on the expression of Caspase-9 and β-Endorphine. Materials and Methods. The expression of the 2 peptides has been identified through immunohistochemistry assay: not …

THE FINGERPRINT OF THE HUMAN GASTROINTESTINAL TRACT MICROBIOTA: A HYPOTHESIS OF MOLECULAR MAPPING

The precise etiology of Inflammatory Bowel Disease (IDB) remains unclear and several factors are believed to play a role in its development and progression, including the composition of microbial communities resident in the gastrointestinal tract. Human intestinal microbiota are extensive with at least 15,000-36,000 bacterial species. However, thanks to the new development in sequencing and molecular taxonomic methodologies, our understanding of the microbiota population composition, dynamics, and ecology has greatly increased. Intestinal microbiota play a critical role in the maintenance of the host intestinal barrier homeostasis, while dysbiosis, which involves reduction in the microbiome…

Preliminary observation of orthodontics self adhesive cement

Videolaparosurrenectomia: nostra esperienza preliminare

INTRODUCTION: In 1992, Gagner described the first laparoscopic adrenalectomy. Since then this technique has been more and more widely employed and several studies confirmed its advantages, comparing to the traditional approach, in terms of reduction of mean hospital stay and therefore of the health expense. PATIENTS AND METHODS: The Authors' preliminary experience spreads from March to November 2003 when 4 patients were studied and thus underwent a transperitoneal laparoscopic adrenalectomy: 2 of them were affected by Cushing syndrome, 1 by pheochromocytoma in MEN and 1 by an incidentaloma. The transabdominal access in lateral decubitus with 4 trocars was performed. RESULTS: No complication…

A MIXTURE OF VEGETABLE EXTRACTS (CHAMOMILLE, PASSIONFLOWER, CARAWAY, FENNEL), AND ENZYMES (BETA-GALACTOSIDASE) FOR IRRITABLE BOWEL SYNDROME (ibs): AN OBSERVATIONAL STUDY ("BIOVES")

Summary. Aims: Irritable bowel syndrome (IBS) is a functional intestinal disorder. This syndrome may creates psychological disorders in patients who are affected and severely limits daily activities and lifestyle. Methods: We investigated the effect of the natural product consisting of chamomile, fennel, caraway, passionflower and melissa (Spasmicol®), on IBS patients. For the study, 187 patients with IBS, enrolled by primary care doctors, were treated with Spasmicol® (Aristeia Farmaceutici s.r.l.), two tablets/daily, for 30 days. At the end of the study, patients were re-evaluated to analyse the effects of therapy. Results: After 30 days, patients showed a marked reduction of symptoms (abd…

Molecular chaperones expression levels and localization in non-tumoral and tumoral thyroid tissues

Papillary thyroid carcinoma (PTC) is the most frequently occurring subtype of thyroid cancer. Exosomes (EXs) secreted from cells to the extracellular environment play an important role in intercellular communication in normality and pathology. Recent data indicates that tumor cells-derived EXs contribute to cancer progression through the modulation of tumor microenvironment(1). Heat Shock Protein (HSPs) are often overexpressed during carcinogenesis and different studies shown that they can be released by tumors cells and that the mechanism of release is mediated by EXs pathway. In this project we performed an immunomorphological study to investigate Hsp60, 90,70,27 levels expression profile…

Capillaroscopic and histological examination of the human labial mucosa: a new non invasive methodology compared with the histological exam

PANORAMIC PERIODONTAL CAPILLAROSCPY: A NEW DIAGNOSTIC METHOD

Hsp60 Involvement During Carcinogenesis

The implication of Hsp60 in cancer development is due to its participation in many metabolic and biomolecular mechanisms in cancer cells. Hsp60 interacts with various molecules that are responsible of apoptosis, cell proliferation and other mechanisms involved when a normal cell becomes malignant. Hsp60 expression was found to be increased in many types of cancer but in same tumors of different anatomical district was found decreased. The mechanism of action of Hsp60 is different depending on the type of tumor. Its involvement in the carcinogenetic process of some tumors, such as large bowel carcinoma or cervical carcinoma, seems to occur in the very early stages of disease. Hsp60 participa…

A BRIEF GUIDE TO THE ANATOMICAL DISSECTION OF THE STOMACH

The purpose of this article is to write a short guide on the macroscopic anatomy of the stomach, describing its structures, its relationships within the abdominal cavity and the dissection methods used during the internship performed by a group of students from the University of Palermo, Palermo, Italy, at the University of Malta, Msida, Malta, during the Summer of 2018. Indeed, they had the opportunity to spend a period of two weeks at the department of Anatomy in the Maltese University for studying and practicing on some corpses, with the aim of improving their anatomical knowledge.

EFFICACY OF ARGENTUM-QUARTZ SOLUTION IN THE TREATMENT OF PERIANAL FISTULAS: A PRELIMINARY STUDY

Objective: Nowadays, an optional and effective medical surgery remains the gold standard for perianal fistulas. Hereby we reported preliminary rsults in favor of using Argentum-Quartz solution for both primary and recurrent perianal fisrtulas. Methods: Three patients with intersphimncter and extrasphinteric fistulas were enrolled. Argentum-Quartz solution was administrated twice a week for sa period of 4 weeks, followed by a pause of 8 days and then another 4 weeks of treatment, totally 16 administrations. After treatment, all patients were monitored for 4-months follow-up. Results: Complete closures of 2 extrasphinteric fistulas and a partial closure with absence of inflammation and supera…

PRELIMINARY TREATMENT ABOUT MODIFICATION OF THE MORFOLOGY OF THE TEETH DURING ORTODONTHIC TREATMENT

PERIODONTAL PANORAMIC CAPILLAROSCOPY: A NEW DIAGNOSTIC METHOD

VIDEOCAPILLAROSCOPIA DELLA MUCOSA ORALE

An uusual case of a partial midgut malrotation

Multiple scerosis: oral manifestations and dental implications.

RECENTLY DEVELOPED FOR DENTINAL ADHESIVES IN RESTORATIVE MATERIALS: MORPHOLOGICAL RESULTS

Il mattatoio tra Marcuse e patronage. Alcune chiavi di lettura dell?opera di Giorgio Pressburger

This article presents the radio-play Il mattatoio (The slaughter house) by the writer and playwright Giorgio Pressburger. The analysis is focused on some main points of the theories of Herbert Marcuse (who is directly mentioned in the incipit of the piece) regarding consumer society and family.  In this work, presented by RAI at the Prix Italia 1967 and aired on the Third Program on the 9th October of the same year, the author is able to describe with intelligence a situation in which Luciano Prisco, an alleged mobster and businessman native of Naples, owner of three slaughterhouses in New York, passes craftily over everything that is not connected to his own social and economic climbing. I…

Oral candidiasis and oral hyperplastic candidiasis: clinical presentation

CARATTERISTICHE CAPILLAROSCOPICHE DEL MICROCIRCOLO LABIALE IN PAZIENTI AFFETTI DA TIROIDITE DI HASHIMOTO

Scanning Electronic Microscopy (SEM) Analysis of the ventriculo peritoneal shunts

Ventricular peritoneal derivations may determinate conditions in the tissues, which may then create fibrous tissues around them. They include cases with catheters of the SEM and they show that when the fibrous tissues are formed, the outer surface is irregular. However, they are not determined through phystolosis or irregular inside the surface

Burning Mouth Syndrome

ABSTRACT Background Burning mouth syndrome (BMS) is an atypical orofacial algesic syndrome. The aim of the authors' research was to investigate the morphological characteristics of peripheral blood circulation in patients with BMS in comparison with those of the peripheral blood circulation in healthy people. Methods The authors examined 28 subjects, of whom 14 (10 women and four men) had BMS and 14 (nine women and five men) were healthy control subjects. They performed videocapillaroscopic examination with a capillaroscope with a fiber-optic probe at a magnification of ×200, which allowed them to examine the morphological characteristics within the capillaroscopic area accurately. Results …

Expression of Nitric Oxide Synthase in inflamed gingival tissue: immunohistochemical and image analysis

We have used 12 Epulis taken during surgical operation and as control, some normal gingival specimen. The aim was to clarify the relationship between the degree of inflammation and NO production in several cases of Epulis, exhibiting different degree of inflammatory process and verifying the presence of cells involved in NO production. From the immuhistochemical data in our possession we can conclude that NO is one of the factor which module the pathogenecity degree of Epulis.

PRELIMINARY STUDIES OF MICROCIRCULATORY IN SEPSI

POSTURE AND POSTUROLOGY, ANATOMICAL AND PHYSIOLOGICAL PROFILES: OVERVIEW AND CURRENT STATE OF ART

Background and aim of work: posture is the position of the body in the space, and is controlled by a set of anatomical structures. The maintenance and the control of posture are a set of interactions between muscle-skeletal, visual, vestibular, and skin system. Lately there are numerous studies that correlate the muscle-skeletal and the maintenance of posture. In particular, the correction of defects and obstruction of temporomandibular disorders, seem to have an impoact on posture. The aim of this work is to collect information in literature on posture and the influence of the stomatognatich system on postural system. Methods: Comparison of the literature on posture and posturology by cons…

PRELIMINARY OBSERVATIONS ABOUT CAPILLAROSCOPIC AND HISTOLOGIC EXAMINATIONS OF THE

IMMUNOLOGICAL ASPECTS OF CROHN’S DISEASE: A REGULATORY FUNCTION OF TIM-3/ GALECTIN-9 IN LYTH1

Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) and its etiology is multifactorial and involves a combination of genetic and environmental factors. The interaction of these factors causes an imbalance in the microbiota, leading to the activation of several immunological and inflammatory mechanisms. From an immunological point of view, there seems to be an involvement of the TIM-3/galectin-9 pathway and of the autoregulation of LyTh1. The studies show that in patients with CD the autoregulation of LyTh1 is lost due to a reduced concentration of galectin-9 and a reduced TIM-3 expression in LyTh1. This could be one of the reasons for the state of perpetual activation in LyTh…

ANATOMICAL DISSECTION AND ANALYSIS OF THE STRUCTURES OF THE UPPER LIMB

In 2015, a whole body dissection course was proposed by the University of Palermo, Palermo, Italy, thanks to the cooperation with the University of Malta, Msida, Malta. The purpose of this study was to show the the difference between the studyof anatomy on books and on corpses. The article focuses its attention on the dissection method of the upper limb. The astudy was performed on two corpses, a male and a female, by using a basic surgeon kit. Blunt dissection method was used for fasciae, innards and to isolate vascular-nervous structures from the fat; we used scalped for cutis, sub cutis, muscles, fasciae, veins, arteries and nerves of the upper limb from the shoulder to the hand. The upp…

A BRIEF DISSECTION GUIDE TO HUMAN THORAX

The purpose of this technical report is to present the experience that, in summer 2018, a group of students from the University of Palermo did at the University of Malta. The students have had the experience to dissected a thorax under the guide of expert dissectors. This work would be also a small dissection guide for young medical students who want to learn the main bases of dissection.

Hsp60, a Novel Target for Antitumor Therapy: Structure-Function Features and Prospective Drugs Design

Heat shock protein 60 kDa (Hsp60) is a chaperone classically believed to be involved in assisting the correct folding of other mitochondrial proteins. Hsp60 also plays a role in cytoprotection against cell stressors, displaying for example, antiapoptotic potential. Despite the plethora of studies devoted to the mechanism of Hsp60's function, especially in prokaryotes, fundamental issues still remain unexplored, including the definition of its role in cancer. Key questions still unanswered pertain to the differences in structure-function features that might exist between the well-studied prokaryotic GroEL and the largely unexplored eukaryotic Hsp60 proteins. In this article we discuss these …

Association between COX-2 rs 6681231 genotype and interleukin-6 in periodontal connective tissue. A pilot study.

[Objectives] The aim of this pilot study was to investigate associations between IL-6 and COX-2 expression in gingival biopsies and both clinical diagnosis and genotypes in the IL-6 and COX-2 genes. [Design] A case-control study included 41 gingival biopsies obtained from Caucasian patients grouped according to clinical diagnosis of gingival health (n = 10), gingivitis (n = 15) or chronic periodontitis (n = 16). Immunohistochemistry analyses were performed to determine COX-2 expression in lamina propria, IL-6 expression in lamina propria and gingival epithelium and level of inflammatory cell infiltrate. Individual DNA was extracted and genotyped by real-time PCR for IL6 SNPs rs 2069827 and …

A rare case of neuroma of the tongue

Antitumoral activity of curcumin: an adjuvant therapeutic strategy

Curcumin, an active substance contained in an Indian spice called turmeric or curcuma, is well known for its anti-inflammatory and antioxidant properties. In recent times, it was taken into account and studied as an antitumoral molecule, by relying on its interference on several biological mechanisms, such as the inhibition of inflammatory mediators, the enhancement of detoxifying enzymes’ action and processes of cell growth and proliferation. Studies show how the high dosage of curcumin in vitro inhibits colorectal tumor cells, pancreatic tumor cells, lung cancer cells and glioblastoma’s cells, interfering in signaling pathways as Wnt/β-catenin, NF-kB and PI3K/Akt and leading to cell cycle…

Panoramic Periodontal Capillaroscopy - a New Diagnostic Method

A DISSECTION’S GUIDE TO HUMAN ABDOMINAL CAVITY

The purpose of this article is to show the abdominal cavity’s dissection method. In the summer of 2018 a group of students from the University of Palermo, who had already taken the anatomy exam and had a good knowledge of English, went for a period of two weeks to do a dissection course at the University of Malta. The students dissected skin, subcutaneously, muscle layers, parietal peritoneum and abdominal organs. This work proves to be a small dissection guide for young medical students who want to learn the main bases of dissection and important information for topographical anatomy.

Variazioni dell'apofisi trasversa della settima vertebra cervicale: studio anatomo - radiologico su una popolazione >

Gli autori hanno studiato le modificazioni morfologiche delle apofisi trasverse della settima vertebra cervicale. Sono state osservate principalmente due variazioni: la mega - apofisi trasversa e la costa cervicale. Gli autori hanno riscontrato una incidenza di variazioni notevolmente superiore rispetto a quanto riportato in letteratura, suppongono che ciò sia dovuto alla relativa > geografica e socio - economica ed ipotizzano una trasmissione genetica di tale variazione del tipo autosomico recessivo.

MICROCIRCULATION AND SEPSIS

Expression of beta-Endorphin and Caspase-9 in orthodontically treated dental pulp

THE ELEVATION OF THE MAXILLARY SINUS. OUR CLINICAL EXPERIENCE. BULLETIN DU GROUPEMENT INTERNATIONAL POUR LA RECHERCHE SCIENTIFIQUE EN STOMATOLOGIE ET ODONTOLOGIE

THE IMPORTANCE OF INTESTINAL MICROBIAL FLORA (MICROBIOTA) AND ROLE OF DIET

In this article we want to analyze the function of the intestinal microbial flora. In the intestinal environment microorganism "good" microrganisms coexist with "bad". The coexistence between good and bad bacteria is balanced by a mutual action of contrast that has the purpose of maintaining the intestinal microbiota flora in a state of equilibrium. This condition is referred eubiosis. This article will attempt to analyze the beneficial role carried out by eubiotic microbial flora showing the negative effects of dysbiosis.

PRELIMINARY OBSERVATIONS ABOUT CAPILLAROSCOPIC AND HISTOLOGIC EXAMINATIONS OF THE HUMAN LABIAL MUCOSA. SURGICAL RADIOLOGIC ANATOMY

SEM ANALYSIS ON THE VENTRICULO PERITONEAL CATHETERS ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY

From Dysbiosis to Neurodegenerative Diseases through Different Communication Pathways: An Overview

The microbiome research field has rapidly evolved over the last few decades, becoming a major topic of scientific and public interest. The gut microbiota (GM) is the microbial population living in the gut. The GM has many functions, such as maintaining gut homeostasis and host health, providing defense against enteric pathogens, and involvement in immune system development. Several studies have shown that GM is implicated in dysbiosis and is presumed to contribute to neurodegeneration. This review focuses mainly on describing the connection between the intestinal microbiome alterations (dysbiosis) and the onset of neurodegenerative diseases to explore the mechanisms that link the GM to nerv…

Intestinal dysbiosis and hormonal neuroendocrine secretion in the fibromyalgic patient

Fibromyalgia is a rheumatic syndrome and its pathogenesis is controversial. The recent literature has placed considerable attention on the link between alteration of the intestinal microbiota and fibromyalgia, emphasizing the close connection between the neuroenteric system and the CNS. This study aims to evaluate the probable relationship between intestinal dysbiosis and altered secretion of hormones and vitamins such as cortisol, serotonin, Vitamin D and thyroid hormones in a patient with fibromyalgia.

Evaluation of the clinical and histological effectiveness of isoretinoin in the therapy of oral leukoplakia. Ten years of experience: is management still up-to-date and effective?

Various studies have evaluated the therapeutic effectiveness of vitamin A derivatives in the treatment of oral leukoplakia (OL). Not all the studies have shown concordant results. The aim of our study, which has a 10-year follow-up, was to test the effectiveness of topical therapy based on 0.18% isotretinoin by comparing it with that most frequently used, i.e., at 0.05% concentration. Forty patients with an established diagnosis of OL were involved in the study. The patients were randomly divided into two groups and the drug was administered topically at 0.05% and 0.18% concentrations. The drug was applied twice a day for 3 consecutive months; then it was suspended for 1 month, and the biop…

AMYLOIDOSIS AND INFLAMMATORY BOWEL DISEASE: FACT OR MITH?

Inflammatory Bowel Disease (IBD), which includes both Crohn's Disease (CD) and Ulcerative Colitis (UC), is a chronic idiopathic inflammatory disorder affecting the gastrointestinal tract. Extraintestinal manifestations (EIM) are common in patients with IBD, and occur in 6-47% of patients with CD or UC. EIM can involve organs other than the gastrointestinal tract such as skin, eyes, joints, biliary tract and kidneis. Renal and urinary involvement particularly occurs in 4-23% of patients with IBD. Among the renal complications of IBD, seconfary amyloidosis (AA-type, AAA) is a rare but serious complication. renal amyloidosis has been proven to be the most common lethal manifestation of IBD-ass…

An unusual case of partial midgut malrotation

Caspase-9 and beta-endorphin expression in human dental pupl subjected to orthodontic traction

Doxorubicin anti-tumor mechanisms include Hsp60 post-translational modifications leading to the Hsp60/p53 complex dissociation and instauration of replicative senescence.

Hsp60 is a pro-carcinogenic chaperonin in certain tumor types by interfering with apoptosis and with tumor cell death. In these tumors, it is not known whether or not doxorubicin anti-tumor effects include a blockage of the pro-carcinogenic action of this protein. We used the human lung mucoepidermoid cell line NCI-H292 and different doses of doxorubicin to measure cell viability, cell cycle progression, cell senescence indicators, Hsp60 levels and its post-translational modifications as well as the release of the chaperonin into the extracellular environment. Cell viability was reduced in relation to doxorubicin dose and this was paralleled by the appearance of cell senescence markers. Con…

Anatomic and microscopic study of ten ventriculo peritoneal distal catheters

ANATOMIA DELL'APPARATO STOMATOGNATICO E DELLE STRUTTURE VICINIORI

Il presente compendio è una riedizione, rivista ed integrata di nuovi capitoli del manuale ”L’apparato buccofaringeo e le strutture ad esso correlate” di V. Valenza edito da Medical Book 1998. Le principali integrazioni hanno riguardato soprattutto i capitoli relativi al cranio, all’articolazione temporo mandibolare e all’innervazione del distretto oro faringeo. Dei capitoli aggiunti, uno è stato dedicato ai denti e l’altro ad argomenti di anatomia pratica. La parte iconografica è stata arricchita di numerose nuove figure originali di cui diverse realizzate dal vivo per rendere più “animata” la trattazione; sono stati aggiunti anche nuovi schemi e tabelle. Si auspica che quanto realizzato p…

RECENTLY DEVELOPED FOR DENTINAL ADHESIVES IN RESTORATIVE MATERIALS

Données immunohistochimiques sur la presence de la Periostine dans le bourgeon dentaire dans un foetus humain de 13 semaines

Valutazioni cliniche e strumentali di fratture di impianti dentali

<i>Il mattatoio</i> entre Marcuse y el patrocinio. Algunas claves para leer la obra de Pressburger

En este artículo se analiza la obra de radio Il mattatoio (El matadero) del escritor y dramaturgo Giorgio Pressburger, sobre todo teniendo en cuenta algunos puntos de los análisis de Herbert Marcuse (mencionado directamente en el incipit de la obra) sobre la sociedad de consumo y la familia. En este trabajo, presentado por la RAI en el Prix Italia 1967 y transmitido por la radio en el Tercer Programa el 9 octubre del mismo año, el autor es capaz de retratar con inteligencia una imagen en la cual Luciano Prisco, supuesto gángster y empresario originario de Nápoles (dueño de tres mataderos en Nueva York), pasa astutamente sobre cualquier valor que no sea relacionado con su escalada social y e…

Probiotics Can Cure Oral Aphthous-Like Ulcers in Inflammatory Bowel Disease Patients: A Review of the Literature and a Working Hypothesis

Dysbiosis has been associated with the onset of several chronic autoimmune or inflammatory pathologies (e.g., inflammatory bowel diseases—IBD), because of its primary role in the establishment of a chronic inflammatory process leading to tissue damage. Inflammatory bowel diseases can even involve areas far away from the gut, such as the extraintestinal manifestations involving the oral cavity with the onset of aphthous-like ulcers (ALU). Studies carried out on animal models have shown that intestinal dysbiosis may be related to the development of autoimmune diseases, even if the mechanisms involved are not yet well known. The aim of this paper is to verify the hypothesis that in inflammator…

Do Fat Supplements Increase Physical Performance?

Fish oil and conjugated linoleic acid (CLA) belong to a popular class of food supplements known as "fat supplements", which are claimed to reduce muscle glycogen breakdown, reduce body mass, as well as reduce muscle damage and inflammatory responses. Sport athletes consume fish oil and CLA mainly to increase lean body mass and reduce body fat. Recent evidence indicates that this kind of supplementation may have other side-effects and a new role has been identified in steroidogenensis. Preliminary findings demonstrate that fish oil and CLA may induce a physiological increase in testosterone synthesis. The aim of this review is to describe the effects of fish oil and CLA on physical performan…

EFFETS D'UN DESENSIBILISANT DENTINAL A BASE D' OSSALATE FERRIQUE: ANALISY AU SEM BULLETIN DU GIRSO

CAPSAICIN STIMULATION AND NEUROGENIC EXPERIMENTALLY INDUCEND INFLAMMATION OF THE HUMAN LABIAL MUCOSA

Vascolarization of Peri-Implant Tisues:Literature Review

In vivo Microperfusion Studies: Validation and Potential Uses in Critical Patients

Recent studies have suggested an increase in sepsis rates, this increase is due to several factors, such as the increase in the average age of the population, the growing number of invasive procedures and use of immunosuppressive drugs. The increase in sepsis incidence causes localized endothelial damage in various regions, it was this aspect that led us to focus the studies on the endothelium and in vivo microperfusion investigations in order to contribute to the scientific knowledge in this field. The present study will meticulously analyze this current and complex issue that affects on a daily basis, everyone involved in critical patient care.

PRELIMINARY TREATMENT ABOUT MODIFICATION OF THE MORPHOLOGY OF THE THEETH DURING ORTHODONTIC TREATMENT

Resection of a giant mediastinal leiomyosarcoma

ABSTRACT Primary leiomyosarcomas of the lung are rare tumors. We report a case of 49-year-old female with history of cough, breathless at rest, right sided chest pain. Chest CT showed a huge (16 cm) mediastinal mass located on the right mediastinum encasing the right main pulmonary artery and infiltrating the main right bronchus and pericardium. The tumor was resected with combined pericardiectomy and pnemonectomy via hemiclamshell incision. This surgical access provided an adequate exposure of the chest “blind zones” and it allowed a radical and safe surgical resection of lung, pleura, pericardium and diaphragm. The final diagnosis showed a low grade differentiation leiomyosarcoma.

SEM ANALYSIS ON THE VENTRICULO PERITONEAL CATHETERS

MORPHOLOGICAL MODIFICATIONS OF VENTRICULO PERITONEAL SHUNTS (VPS)

PRELIMINARY TREATMENT ABOUT MODOFICATION OF THE MORPHOLOGY OF THE TEETH DURING ORTHODONTIC TREATMENT

Oral manifestation of Kawasaki disease

Evaluation of two different endodontic filling materials and their adaptation to the canal walls using System B.

Permanence of Modifications in Oral Microcirculation in Ex-Smokers.

Background: The aim of this study was to assess the long-term effects of smoking and to investigate the permanence of this damage to the oral microcirculation. Material/Methods: We recruited 75 patients and divided them into 3 groups: group 1 was composed of 25 healthy non-smokers, group 2 was composed of 25 healthy current smokers, and group 3 was composed of 25 healthy ex-smokers. Video-capillaroscopic examination was performed on all patients. The video-capillaroscopic investigation was performed on patients in sitting position, always with the same light source, at the same room temperature (23°C), in the morning, with the same operator (GAS), and was repeated many times for every area …

PANORAMIC PERIODONTAL CAPILLAROSCOPY: A NEW DIAGNOSTIC METHOD. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY

PEMPHIGUS VULGARIS IN A MEDITERRANEAN YOUNG ADULT MANIFESTING AS DESQUAMATIVE GINGIVITIS

ORTODONZIA PREPROTESICA-UPRIGHTING MOLARE MEDIANTE DISPOSITIVO MODIFICATO

ASSOCIATION BETWEEN HELYCOBACTER PYOLRI INFECTION AND PATHOLOGICAL ORAL MANIFESTATIONS

DATA FROM LITERATURE ARE CONTROVERSAL REGARDING THE PRESENCE OF bELICOBACTER PYLORI (HP) IN DENTAL PLAQUE AND ITS ASSOCIATION WITH GASTRIC INFECTION. oNE OF THE POSSIBLE MECHANISMS SUGGETSED FOR RE-INFECTION IS THE RECOLONIZATION WITH HP DENTAL PLAQUE. THE PURPOSE OF THIS REVIEW WAS TO DETERMINE WHETHER DENTAL PLAQUE, POOR ORAL HYGIENE, AND PERIODONTAL DISEASE WERE RISK FACTORS FOR HP INFECTION.

Emerging Immnunohistochemical evidence for Direct Peripheral Control of Endocannabinoids on the Gastrointestinal Tract and Pancreas of Obese (fa/fa)and Lean Zucker Rats (Pathophysiological Implications)

This research has the objective to investigate immunohistochemical expression of CB1 receptor and its probable changes in Gastroenteropancreatic system (GEP) of obese and lean Zucker rats and understand the endocannabinoid pathophysiological implications in the obesity. Male obese (fa/fa) and lean Zucker rats 6 weeks old were obtained from Harlan Italy Srl; the rats were sacrificed at 8, 12 and 16 weeks old. Normal rats also were sacrificed. Specimens of stomach, jejunum-ileum and pancreas were fixed in Bouin’s mixture and embedded in paraffin; obtained sections were processed with anti-CB1 (Biosource Europe SA) by Streptavidin-Biotin-Complex Method. The findings show that CB1 receptor is e…

Simple and fast orotracheal intubation procedure in rat

Introduction: Endotracheal intubation in the rat is difficult because of extremely small size of anatomical structures (oral cavity, epiglottis and vocal cords), small inlet for an endotracheal tube and the lack of proper techniacal instruments. Matherial and Methods: In this study we used seventy rats weighthing 400-500 g. The equipment needed for intubation was an operating table, a longish of cotton, a cotton tip, orotracheal tube, neonatal laryngoscope KTR4, small animal ventilator, and isoflurane for inhalation anaesthesia. Premedication was carried out by medetomidine hydrochloride 1 mg/mL; then, thanks to a closed glass chamber, a mixture of oxygen and isoflurane was administered. By…

Hsp60 as a Novel Target in IBD Management: A Prospect

Inflammatory bowel disease (IBD) encompasses various pathological conditions similar but distinct that share a multifactorial etiology, including involvement of the intestinal barrier function, the immune system, and intestinal microorganisms. Hsp60 is a chaperonin component of the chaperoning system, present in all cells and tissues, including the intestine. It plays important roles in cell physiology outside and inside mitochondria, its canonical place of residence. However, Hsp60 can also be pathogenic in many conditions, the Hsp60 chaperonopathies, possibly including IBD. The various clinico-pathological types of IBD have a complicated mix of causative factors, among which Hsp60 can be …

P-14 EVALUATION OF TWO DIFFERENT ENDODONTIC FILLING MATERIALS AND THEIR ADAPTATION TO THE CANAL WALLS USING SYSTEM B

Colorectal Carcinogenesis: Role of Oxidative Stress and Antioxidants

One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanisms. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate the role of oxidative stress in promoting colorectal carcinogenesis and to highlight the potential protective role of antioxidants. Several studies have documented the importance of antioxidants in countering oxidative stress and preventing colorectal carcinogenesis. However, there are conflicting data in the literature concerning its proper use in humans, since these studies did not yield defin…

Incidentaloma Surrenalico. Caso di Sindrome di Cushing subclinica.

The authors describe a case of adrenal incidentaloma that was the cause of subclinical Cushing's syndrome and take the opportunity to weigh up some of the clinical, diagnostic and therapeutic aspects. Besides the particular expression of the symptoms which were difficult to interpret before reaching a diagnosis, the authors describe the diagnostic work-up adopted, aimed at precisely identifying the type of tumour and the surgical procedure implemented laparoscopically, the outstanding validity of which is confirmed compared to traditional adrenalectomy techniques.

Incidentaloma surrenalico: sindrome di Cushing subclinica

ANATOMIC AND MICROSCOPIC STUDY OF THE VENTRUCULO PERITONEAL DISTAL CATETHERS IN CHILD'S NERVOUS SYSTEM

Evaluation of the serum levels of retinol in patients affected by leukoplakia and oral lichen planus: a statistical analysis.

VASCULARIZATION OF PERI IMPLANT TISSUES: LITERATURE REVIEW

Periodontal morphological microcirculation in Oral Lichen Planus

This study aimed at evaluating possible differences in the vascular pattern (of periodontal mucosa microcirculation) between healthy patients and patients suffering from PLP (periodontal lichen planus). Fifty-four patients (27 patients suffering from PLP and 27 healthy patients) were examined by means of videocapillaroscopy. The following area was examined for each patient: periodontal mucosa corresponding to 1.1 and 2.1. The following parameters were analyzed on every capillaroscopic image: capillary loop length, loop diameter, capillary tortuosity, capillary density, avascular areas, possible microhaemorrhages, distinctive morphology. The results obtained using videocapillaroscopic softwa…

CANALAR REPROCESSING WITH NI-TI INSTRUMENTS: OUR EXPERIENCE ITALIAN JOURNAL OF ANATOMY AND EMBRIOLOGY

A randomized trial assessing the effectiveness of different concentrations of isotretinoin in the management of lichen planus

The aim of our 10-year study was to test the effectiveness of topical therapy based on 0. 18% isotretinoin, comparing it with that most frequently used, i.e. at 0.05% concentration. Seventy patients with an established diagnosis of oral lichen planus were involved in the study. The patients were randomly divided into two groups, and the drug was administered topically at 0.05% and 0. 18% concentrations. The drug at the higher concentration, according to the same protocol, was administered to the patients who did not benefit from the therapy at the lower concentration. None of the cases of reticular lichen planus showed clinical or histological improvement. In contrast, the atrophic-erosive …

L'ESAME CAPILLAROSCOPICO ORALE: NUOVA METODICA DIAGNOSTICA

The morphological-functional study of microcirculation is of fundamental importance; in fact, the microvascular bed is directly involved both in autoimmune etiopathogenesis pathologies, and in acute and chronic inflammatory etiopathogenesis pathologies. Oral capillaroscopy is a very stimulating method for studying microcirculation, because of the possibility of studying small vessels in vivo by means of a microscope. Today, it is becoming more reliable thanks to the improvement of the observation tools (photography, videomicroscopy).

Oral capillaroscopy: our experience

Capillaroscopy has now definitely become an important and indispensable exam in the area of diagnosing vasculopathies and in particular micro angiopathies. The type of damages connected to these anatomy pathologies regarding the actual micro vascular unit work in a functional pathogenic of an extreme importance, in conditioning the course and the eventual aggravation of micro angiopathies properly called vasculity and also of macro angiopaties. In all, this underlines the great importance achieved by using certain instrumental exams which complements the clinical research, exactly because of the valid elements which have been given for a complete and precise morphological valuation for the …

Quantitative patterns of Hsps in tubular adenoma compared with normal and tumor tissues reveal the value of Hsp10 and Hsp60 in early diagnosis of large bowel cancer

Large bowel carcinogenesis involves accumulation of genetic alterations leading to transformation of normal mucosa into dysplasia and, lastly, adenocarcinoma. It is pertinent to elucidate the molecular changes occurring in the pre-neoplastic lesions to facilitate early diagnosis and treatment. Heat shock proteins (Hsps), many of which are molecular chaperones, are implicated in carcinogenesis, and their variations with tumor progression encourage their study as biomarkers. There are many reports on Hsps and cancer but none to our knowledge on their systematic quantification in pre-neoplastic lesions of the large bowel. We performed immunohistochemical determinations of Hsp10, Hsp60, Hsp70, …

Microcirculation in the healing of surgical wounds in the oral cavity.

Abstract. The aim of this research is to evaluate in vivo the characteristics of microcirculation after taking a biopsy sample from the oral mucosa. 20 patients were recruited to the study and all underwent an oral mucosa biopsy for the excision of benign neoformations. The modifications in the oral microcirculation were evaluated in vivo in correspondence to the surgical site through videocapillaroscopy at three different times: 30 min before the biopsy; 48 h after the biopsy; and 7 days after the biopsy. The statistical significance was checked with the Mann–Whitney U-test (P < 0.05). The analysis of videocapillaroscopic patterns showed statistically significant variations relative to the…

APPRAISAL AND PROMATION OF THE ORAL HEALTH IN A GROUP OF VISUALLY IMPAIRED PATIENTS

FRATTURA DI IMPIANTI DENTARI. CASO CLINICO

Antinflammatory effect of Levorag® (THD) emulgel on radiation proctocolitis around a colo-anal anastomosis

Hsp60 and human aging: Les liaisons dangereuses 

Stressors can cause abnormal intracellular accumulation of Hsp60 and its localization in extramitochondrial sites, secretion, and circulation, with immune system activation. Dysfunction of chaperones associated with their quantitative and qualitative decline with aging (chaperonopathies of aging) characterizes senescence and is a potential causal factor in the physiological deterioration that occurs with it. The role of Hsp60 in aging is not easy to elucidate, because aging is accompanied by pathologies (e.g., cardiovascular and neurodegenerative disorders, osteoporosis, diabetes, cancer, etc.) in which Hsp60 has been implicated but, although those disorders are more frequent in the elderly…

Burning mouth syndrome: An evaluation of in vivo microcirculation

Background. Burning mouth syndrome (BMS) is an atypical orofacial algesic syndrome. The aim of the authors’ research was to investigate the morphological characteristics of peripheral blood circulation in patients with BMS in comparison with those of the peripheral blood circulation in healthy people. Methods. The authors examined 28 subjects, of whom 14 (10 women and four men) had BMS and 14 (nine women and five men) were healthy control subjects. They performed videocapillaroscopic examination with a capillaroscope with a fiber-optic probe at a magnification of ×200, which allowed them to examine the morphological characteristics within the capillaroscopic area accurately. Results. The ca…

SELENIUM AND AUTOIMMUNE THYROIDITIS

Selenium (Se) is an essential trace element of pivotal importance to human health. Se is incorporated into selenoproteins (SePs) which have pleiotropic effects, including antioxidant and anti-inflammatory effects, and in the production of active thyroid hormone. These findings may explain the relationship between Se deficiency and pathogenesis of various human diseases including thyroid disorder. In line with these observations, the therapeutic effectiveness of Se supplementation has already been reported in patients with various thyroid diseases. However, there are still controversial data about the optimal dose of Se to be administered, as well as the duration and efficacy of treatment an…

A brief anatomo-surgical dissection guide to human mediastinal anatomy: results of the collaboration between the University of Palermo and the University of Malta.

In the summer of 2017, thanks to an agreement between the University of Malta and the University of Palermo, a group of students from the University of Palermo, who had already taken the anatomy exams and had a good knowledge of English, went for a 4 week period to the University of Malta to follow a dissection course . The students dissected skin, the sternum, the vessels, the nerves, analyzed the pericardium, the lungs and all the mediastinal organs. This work proves to be a small dissection guide for young medical students who want to learn the basics of dissection and the relevant topographical anatomy. The students were selected by the University of Palermo because of the good quality …

Multiple Sclerosis: Oral Manifestations and Dental Implications

VASIDILATATION OF HUMAN GINGIVA AND NEUROGENIC INFLAMMATION

ORTODONZIA PREPROTESICA. UPRIGHTING MOLARE MEDIANTE DISPOSITIVO MODIFICATO

ROUTINARY USE OF FIBRIN SEALANTS TO PREVENT PROLONGED AIR LEAK IN THORACIC SURGERT: OUR EXPERIENCE

Introduction: prolonged air leak (PAL) is one of the most common postoperative complications after lung surgery. It is associatred with increased significant morbidity, lower quality of life, longer hospital stay and higher hospital costs. Since its great clinical and economic burden, it is important to establish the feasibility and the effectiveness of the routinary preventive use of a fibrin sealant in order to reduce the incidence of prolonged air leaks. Patients and methods: this is a randomized study on 189 adult patients - 118 men (62,4%) and 71 women (37,6%) aged from 39 to 87 y.o. (mean age 68,3 y.o.) - who underwent lung surgery (lobectomy or bilobectomy) with intraoperatory detect…

A brief anatomo-surgical dissection guide to the human neck: results of a collaboration between the University of Palermo and the University of Malta.

The aim of this work was to offer a guide to young students and medical doctors that want to learn the bases of neck dissection. In the summer of 2017 a group of students from the University of Palermo that had already passed the Human Anatomy exams took a 4 weeks dissection course at the University of Malta Medicine is a science that requires both a practical and theoretical approach, and the last one, unfortunately, often is not valued by our University. Studying Human Anatomy, which is the basis for a doctor's education, exclusively through books and atlases, is indeed partially lacking. For this reason a group of students from the University of Palermo have been selected, based on their…

ORAL MICROBIOTA: CHARACTERISTICS, RELATED PATHOLOGIES AND FUTURE PROSPECTS

The oral microbiota is represented by the set of bacteria and microrganisms that reside in the oral cavity. It is formed from bird and stabilizes during the period of permanent dentition. The oral microbiota poresents from 500 to 700 bacterial species, belonging to six main phyla, Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria, Spirochaetes and Fusobacteria. These bacteria partecipate in the formation of dental plaque, a sort of biofilm that deposits on the rigid surfaces of the oral cavity, and contributes to the healthy maintenance of the oral cavity. An alteration of the oral microbiota contributes to the pathogenesis of periodontitis, caries, gingivitis and also of systemic d…

The long-term effects of probiotics in the therapy of ulcerative colitis: a clinical study

Aim: Intestinal dysbiosis seems to be the leading cause of inflammatory bowel diseases, and probiotics seems to represent the proper support against their occurrence. Actually, probiotic blends and anti-inflammatory drugs represent a weapon against inflammatory bowel diseases. The present study evaluates the long-term (2 years) effects of combination therapy (mesalazine plus a probiotic blend of Lactobacillus salivarius, Lactobacillus acidophilus and Bifidobacterium bifidus strain BGN4) on ulcerative colitis activity. Method: Sixty patients with moderate-to-severe ulcerative colitis were enrolled: 30 of them were treated with a single daily oral administration of mesalazine 1200 mg; 30 pati…

Insights on Central and Peripheral Venous Catheterization; Biology, Anatomy, Surgical Aspects and Nursing Management (Our Experience)

After a review of the main anatomical districts of relevance to central and peripheral venous catheterization, we analyze the primary guidelines for the management of cannulation of central and peripheral venous catheters; a background study relative to this subject is then carried out. The aim of the present study is to review the main central and peripheral catheterization methods, and to share our experience with particular emphasis on analyzing common complications

MACROLIDES ANTIBIOTICS IN ODONTOSTOMATOLOGICAL PRACTICE:PAST. PRESENT AND FUTURE

VALUTAZIONI CLINICHE E STRUMENTALI DI FRATTURE DI IMPIANTI DENTALI: PRESENTAZIONE DI UN CASO CLINICO

EFFECTS OF A FERRIC OXALATE DENTIN DESENSITIZER: SEM ANALYSIS