6533b7dcfe1ef96bd1273457
RESEARCH PRODUCT
The Chlamydomonas genome reveals the evolution of key animal and plant functions
Lillian K. Fritz-laylinEmilio FernándezWing Chi Abby NgauKamel JabbariM. Dudley PageAndrea L ManuellJinal JhaveriWilliam InwoodTelsa M. MittelmeierSusan K. DutcherChong-jian ChenMichael SchrodaCharles R. HauserDiego MartinezWallace F. MarshallLaurence Maréchal-drouardJeremy SchmutzMartin H. SpaldingRachel M. DentJunmin PanLeila HornickStéphane D. LemaireGreg PazourSabeeha S. MerchantErika LindquistYigong LuoAlexander PoliakovDavid González-ballesterJane GrimwoodMaria MittagMartin T. CroftDavid R. NelsonSara L. ZimmerPierre CardolPierre CardolSathish RajamaniRobert D. WillowsSanja RojeHeriberto CeruttiJoanne C. LongMichael HipplerHeidi K. LedfordMing KalanonJames G. UmenY. Wayne HuangOlivier VallonAaron PorterInna DubchakChun-long ChenGeorge B. WitmanSimon E. ProchnikLinda A. RymarquisJeffrey L. MoseleyArmin HallmannCarolyn A. NapoliBernd Mueller-roeberQinghu RenDavid B. SternDaniel S. RokhsarDaniel S. RokhsarAnton A. SanderfootJanneke BalkIan T. PaulsenWayne R. RiekhofMary Rose LambMarc HanikenneIgor V. GrigorievPaul A. LefebvreChris BowlerMarek EliášVadim N. GladyshevKemin ZhouSaul PurtonStephen P. MayfieldRichard KurasLaurens MetsGuillaume ChanfreauKaterina BisovaHideya FukuzawaPamela J. GreenSergey V. NovoselovJens AllmerSteven G. BallElizabeth H. HarrisKarla C GendlerLiang-hu QuSteven J. KarpowiczSusan LucasDiego Mauricio Riaño-pachónLukasz SzajkowskiKrishna K. NiyogiAimee M. TerauchiAstrid TerryPatrick J. FerrisNedra F. WilsonArthur R. GrossmanWirulda PootakhamAnnkatrin RoseHarris ShapiroGregory WernerBobby OtillarValérie CognatCarol L. DieckmannAlexey V. LobanovJun MinagawaPeter BroksteinEric StahlbergJames V. MoroneyRichard A. JorgensenMartin LohrAurora M. NedelcuDiego González-halphenIris MeierPinfen YangRichard T. SayreAsaf SalamovVladimir V. KapitonovDavid GoodsteinJean-philippe Ralsubject
0106 biological sciencesMESH: Sequence Analysis DNAMESH: Algal ProteinsChloroplastsProteomeMESH: PlantsChlamydomonas reinhardtii01 natural sciencesGenomeMESH: Membrane Transport ProteinsDNA AlgalMESH: DNA AlgalMESH: AnimalsGoniumPhotosynthesisMESH: PhylogenyMESH: PhotosynthesisPhylogenyGenetics0303 health sciencesGenomeMultidisciplinarybiologyMESH: Genomicsfood and beveragesGenomicsPlantsBiological EvolutionMESH: Genes[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biomolecules [q-bio.BM]MESH: ProteomeFlagellaMultigene FamilyMESH: Computational BiologyMESH: Chlamydomonas reinhardtiiNuclear geneMolecular Sequence Data[SDV.BC]Life Sciences [q-bio]/Cellular BiologyFlagellumMESH: FlagellaArticle03 medical and health sciencesIntraflagellar transportMESH: EvolutionAnimalsMESH: Genome[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM]Gene[SDV.BC] Life Sciences [q-bio]/Cellular Biology030304 developmental biologyMESH: Molecular Sequence DataMESH: ChloroplastsAlgal ProteinsChlamydomonasComputational BiologyMembrane Transport ProteinsSequence Analysis DNAbiology.organism_classificationGenesMESH: Multigene FamilyChlamydomonas reinhardtii010606 plant biology & botanydescription
Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It is a model system for studying chloroplast-based photosynthesis, as well as the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited from the common ancestor of plants and animals, but lost in land plants. We sequenced the ∼120-megabase nuclear genome of Chlamydomonas and performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated with the function and biogenesis of chloroplasts or eukaryotic flagella. Analyses of the Chlamydomonas genome advance our understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-10-12 |