6533b871fe1ef96bd12d11f1
RESEARCH PRODUCT
Assessment of a single-acquisition imaging sequence for oxygen-sensitive (3)He-MRI.
Klaus MarkstallerJ. BermuthHans-ulrich KauczorJörg SchmiedeskampReinhard SurkauWolfgang SchreiberBalthasar EberleErnst-wilhelm OttenAnselm DeningerB. Escatsubject
ChemistryPartial PressureMonte Carlo methodHealthy subjectschemistry.chemical_elementrespiratory systemOxygenHeliumMagnetic Resonance ImagingOxygenNuclear magnetic resonanceIsotopesHistogramImage Processing Computer-AssistedHumansRadiology Nuclear Medicine and imagingLimiting oxygen concentrationComputer SimulationHyperpolarization (physics)Inhaled GasPulmonary VentilationLungMonte Carlo MethodLung functiondescription
MRI of the lungs using hyperpolarized helium-3 (3He) allows the determination of intrapulmonary oxygen partial pressures (pO2). The need to separate competing processes of signal loss has hitherto required two different imaging series during two different breathing maneuvers. In this work, a new imaging strategy to measure pO2 by a single series of consecutive scans is presented. The feasibility of the method is demonstrated in three healthy human volunteers. Maps and histograms of intrapulmonary pO2 are calculated. Changes in the oxygen concentration of the inhaled gas mixture are well reproduced in the histograms. Monte Carlo (MC) simulations of the temporal evolution of 3He hyperpolarization within the lungs were performed to evaluate the accuracy of this measurement technique, and its limitations. Magn Reson Med 47:105–114, 2002. © 2002 Wiley-Liss, Inc.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-12-20 | Magnetic resonance in medicine |