Plataformas digitales en el sector de los VTC

2021

El del transporte urbano de pasajeros con vehículos turismo (taxi y VTC) es, seguramente, el sector donde la irrupción de la economía colaborativa –o, si se prefiere decir así, las plataformas digitales– ha dado lugar a controversias más encendidas, medidas regulatorias más cuestionables y un mayor número de pleitos. En el presente trabajo se hace un breve repaso de las cuestiones regulatorias más candentes que se han planteado, haciendo hincapié en las que todavía están pendientes de resolución en un sentido que no parece fácil avizorar.

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2021

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease with no therapeutic consensus. Oxidation and inflammation are hallmarks in the progression of this complex disease, which also involves interactions between the genetic background and the environment. Mastiha is a natural nutritional supplement known to possess antioxidant and anti-inflammatory properties. This study investigated how a 6-month Mastiha supplementation (2.1 g/day) could impact the antioxidant and inflammatory status of patients with NAFLD, and whether genetic variants significantly mediate these effects. We recruited 98 patients with obesity (BMI ≥ 30 kg/m2) and NAFLD and randomly allocated them to eit…

The Moderating Effect of Store Format on the Relationships Between ICT, Innovation and Sustainability in Retailing

2021

Innovation and sustainability are postulated as key variables for the future of large commercial distribution. In addition, the development of Information and Communication Technologies (ICT) solutions, and especially those related to Artificial Intelligence (i.e., Just Walk Out, Intelligent Retail Lab) and digitization, are particularly relevant factors in the current pandemic scenario in which retail companies operate. These tools are essential to face the derived changes in commercial relations, especially between companies and consumers. For all these reasons, this work aims to examine the effect of ICT, as a driving factor for innovation and its direct and indirect impact on sustainabi…

Interpreting protohistoric societies through place names of landscape features: a case study in València, Spain

2021

Protohistoric place names, created before written history and related to extinct languages, are analysed in this article. Our case study deals with place names of current towns (over 20,000 inhabit...

Designing Recommendation or Suggestion Systems: looking to the future

2021

A Recommendation or Suggestion System (RSS) helps on-demand digital content and social media platforms identify associations amongst large amounts of transaction data, which are then used to provide personalised viewing and shopping recommendations to consumers. This preface introduces how RSSs are used in the marketplace and various purposes it serves. This paper is a contribution to the ongoing research beyond content-based recommender system. It presents an examination of how the Collective Intelligence Social Tagging System makes a fundamental difference to content-based recommender systems and a suggested hybrid approach to RSS architecture which uses crowdsourcing and tagging to incre…

Withanone Ameliorates Stress Symptoms in Caenorhabditis Elegans by Acting through Serotonin Receptors

2021

ABSTRACT Introduction Depression is responsible for 800 000 deaths worldwide, a number that will rise significantly due to the COVID-19 pandemic. Affordable novel drugs with less severe side effects are urgently required. We investigated the effect of withanone (WN) from Withania somnifera on the serotonin system of wild-type and knockout Caenorhabditis elegans strains using in silico, in vitro, and in vivo methods. Methods WN or fluoxetine (as positive control drug) was administered to wild-type (N2) and knockout C. elegans strains (AQ866, DA1814, DA2100, DA2109, and MT9772) to determine their effect on oxidative stress (Trolox, H2DCFDA, and juglone assays) on osmotic stress and heat stres…

Electrosynthesis of Stable Betulin‐Derived Nitrile Oxides and their Application in Synthesis of Cytostatic Lupane‐Type Triterpenoid‐Isoxazole Conjuga…

2021

Education and long-term outcomes in first episode psychosis: 10-year follow-up study of the PAFIP cohort

2021

[Background] Lower levels of education have been associated with the development of psychosis. Investigating educational achievement in the first episode of psychosis (FEP) patients may shed light on the origins of the alterations and on the variability of outcomes in psychotic disorders.

Pair production due to an electric field in 1+1 dimensions and the validity of the semiclassical approximation

2021

Solutions to the backreaction equation in $1+1$-dimensional semiclassical electrodynamics are obtained and analyzed when considering a time-varying homogeneous electric field initially generated by a classical electric current, coupled to either a quantized scalar field or a quantized spin-$\frac{1}{2}$ field. Particle production by way of the Schwinger effect leads to backreaction effects that modulate the electric field strength. Details of the particle production process are investigated along with the transfer of energy between the electric field and the particles. The validity of the semiclassical approximation is also investigated using a criterion previously implemented for chaotic i…

Data from: “A cleaner break”: genetic divergence between geographic groups and sympatric phenotypes revealed in ballan wrasse (Labrus bergylta)

2021

Capture and long-distance translocation of cleaner fish to control lice infestations on marine salmonid farms has the potential to influence wild populations via overexploitation in source regions, and introgression in recipient regions. Knowledge of population genetic structure is therefore required. We studied the genetics of ballan wrasse, a phenotypically diverse and extensively used cleaner fish, from 18 locations in Norway and Sweden, and from Galicia, Spain. We detected two very distinct genetic groups in Scandinavia, northwest and southeast. These groups were split by a stretch of sandy beaches in southwest Norway, representing a habitat discontinuity for this rocky shore associated…

L'expérience d'un concept. Vers un nouvel âge postexpérientiel ?

2021

Without ignoring the philosophical tradition, particularly phenomenology, experience is apprehended here through the crossroads of marketing, communication and semiotics. A first paradigmatic shift with marketing, from experience to the experiential. Then the enlargement of the experiential sequence, its figurative expansion, from the anticipation of the experience to its reconfiguration. Finally, the modal colourations of experience as free modulations of life forms, with style and manner, far from a formatted and instrumentalised model of experience.

Opioid epidemic spread from Northern and Eastern Europe to Mediterranean Area.

2021

The addiction to illicit opioid and the misuse of prescription synthetic opioids pain relievers and fentanyl analogs generated an opioid epidemic in North America over the last two decades that affected public health with a constantly rising number of overdoses deaths. This health treat moved to Europe with a significant increase starting from 2015 involving mainly norther and eastern countries and finally also the Mediterranean area. The "lock down" isolation and economic recession caused by COVID-19 pandemic showed a resurgence in opioid use and harms.

Phenotyping, ecophysiology and molecular physiology to characterize plant root system architecture and plant-plant and plant-microorganisms interacti…

2021

International audience; Agriculture is facing the challenges to improve performance and crop adaptation to climate change towards reducing negative impacts of associated abiotic stresses on crop yield and contributing to its mitigation. Climate change comprises more frequent and ample abiotic stresses that plants have to cope with, such as drought, the most important limitation to yield stability and plant harvest product quality which often lead to hydromineral nutritional stress. The capacity of plants to extract nutrients and water from a given volume of soil depends on root system architecture and on intrinsic factors such as the production of root exudates and the efficiency for resour…

Carbonates from the ancient world's longest aqueduct:A testament of Byzantine water management

2021

The fourth‐ and fifth‐century aqueduct system of Constantinople is, at 426 km, the longest water supply line of the ancient world. Carbonate deposits in the aqueduct system provide an archive of both archaeological developments and palaeo‐environmental conditions during the depositional period. The 246‐km‐long aqueduct line from the fourth century used springs from a small aquifer, whereas a 180‐km‐long fifth‐century extension to the west tapped a larger aquifer. Although historical records testify at least 700 years of aqueduct activity, carbonate deposits in the aqueduct system display less than 27 years of operation. This implies that the entire system must have been cleaned of carbonate…

Detection of polymer compatibility by means of self-organization: poly(ethylene oxide) and poly(sodium 4-styrenesulfonate)

2021

Information on the miscibility of different polymers A and B on a molecular level is important in many ways. However, along the traditional lines this knowledge is difficult and time consuming to achieve. The current study presents a simple alternative, based on the determination of the intrinsic viscosities (specific hydrodynamic volume of isolated coils) for blend solutions in a common solvent. In the case of incompatible polymers, isolated coils contain one macromolecule only, either A or B. In contrast, compatible polymers form mixed isolated coils, because of favorable interactions. The present investigation was carried out for the system water/poly(ethylene oxide)/poly(sodium 4-polyst…

Typification of Dactylis ibizensis (Poaceae) and inference of the ploidy level of the type specimen

2021

Production and Characterization of Medium-Sized and Short Antioxidant Peptides from Soy Flour-Simulated Gastrointestinal Hydrolysate.

2021

Soybeans (Glycine max) are an excellent source of dietary proteins and peptides with potential biological activities, such as antihypertensive, anti-cholesterol, and antioxidant activity

I am, I speak, therefore I am: cognitive and philosophical study of linguistic neoteny

2021

How do we exist in the world? And how to settle down effectively in one language or another language? This article is largely based on reflections of the book Linguistics, cognition and didactics. Principles and exercises of linguistic-didactic, masterpiece of linguist Samir Bajrić. In this text, we are mainly interested in cognition, language, and the appropriation of a language or another language, and in which we conduct a cognitive, linguistic and philosophical research on the human being and on the speaker-being while taking advantage of linguistic neoteny. The languages analyzed in this text are mainly French and Mandarin.

La pensée uexküllienne de la vie et ses enjeux écologiques

2021

International audience

Missense variants in DPYSL5 cause a neurodevelopmental disorder with corpus callosum agenesis and cerebellar abnormalities

2021

International audience; The collapsin response mediator protein (CRMP) family proteins are intracellular mediators of neurotrophic factors regulating neurite structure/spine formation and are essential for dendrite patterning and directional axonal pathfinding during brain developmental processes. Among this family, CRMP5/DPYSL5 plays a significant role in neuronal migration, axonal guidance, dendrite outgrowth, and synapse formation by interacting with microtubules. Here, we report the identification of missense mutations in DPYSL5 in nine individuals with brain malformations, including corpus callosum agenesis and/or posterior fossa abnormalities, associated with variable degrees of intel…

New Sperm Morphology Analysis in Equids : Trumorph ® Vs Eosin-Nigrosin Stain

2021

Equine Reproduction Service. Department of Animal Medicine and Surgery. Veterinary Faculty. Autonomous University of Barcelona. National Agency for Research and Development (ANID), Ministry of Education, Chile (2017/72180128). Secretary of Higher Education, Science, Technology and Innovation (SENESCYT)(CZ02-000507-2019) The evaluation of the male fertility potential is based on the analysis of the basic spermatic characteristics of concentration, motility and morphology. Thus, the study of sperm morphology is a fundamental element in the seminal analysis, but its real meaning has been biased by the techniques used for its evaluation. These techniques involve dehydration phases and subsequen…

Synthesis of Morphinans through Anodic Aryl‐Aryl Coupling

2021

The morphinans are an important class of structurally fascinating and physiologically important natural products as exemplified by the famous opium alkaloids of the morphine family. Although this class of secondary metabolites from the juice of the opium poppy capsule was already used for medicinal purposes thousands of years ago, chemical modifications are still being applied to the core structure today in order to achieve the most specific effect on the various receptor subtypes possible with the fewest possible side effects. The unusual architecture of the morphinan core has also proven to be a highly challenging target for total synthesis. This review highlights electrosynthetic approac…

Interstitial carbon defects in silicon. A quantum mechanical characterization through the infrared and Raman spectra.

2021

The infrared (IR) and Raman spectra of eight substitutional carbon defects in silicon are computed at the quantum mechanical level by using a periodic supercell approach based on hybrid functionals, an all electron Gaussian type basis set and the CRYSTAL code. The single substitutional C s case and its combination with a vacancy (C s V and C s SiV) are considered first. The progressive saturation of the four bonds of a Si atom with C is then examined. The last set of defects consists of a chain of adjacent carbon atoms C s i , with i = 1-3. The simple substitutional case, C s , is the common first member of the three sets. All these defects show important, very characteristic features in th…

Six points à retenir sur les déterminants de la "juste" portion [expertise pour Nestlé]

2021

Membres du comité d'experts ayant participé à la réflexion :Sandrine Monnery-Patris ; Pascale Hebel ; Ghislain Grodard ; Thibaut de Saint Pol et Marie-Josèphe Amiot-Carlin Référence interne : EAPP; Nestlé a initié une réflexion avec un comité d'experts pluridisciplinaires indépendants pour identifier et comprendre les déterminants de la portion, levier essentiel, mais complexe, pour réguler la prise alimentaire.La synthèse de leurs réflexions s’articule en 6 points clés, soutenus par une analyse de la littérature scientifique, qui sont : • Une portion ni normée, ni injonctive• Une portion réaliste• Une portion personnalisée• Une portion associée à l’hédonisme• Une portion qui intègre les as…

DEVELOPMENT OF NONTOXIC BIO-ADHESIVES FOR WET ENVIRONMENTS

2021

Practical Implementation of a Synchronous PWM Strategy for Low Switching Frequency FOC of im Drives with ATSAM3X8E Microcontroller

2021

This paper presents a practical implementation of synchronous PWM modulation algorithm for an induction motor field oriented control powered by a DC/AC inverter and implemented on a low-cost microcontroller, the ATSAM3X8E. In particular, a simple algorithm, capable to calculate automatically an optimized set of frequency modulation indexes will be presented. Hysteresis bands are also introduced in the algorithm in order to avoid multiple changeovers during modulation index transitions. Experimental tests and their results will be shown and discussed, highlighting the benefits of the present algorithm, such as reduction of current harmonic content, reduction of current ripple and, consequent…

DEVELOPMENT & QUALIFICATION OF BIOASSAYS FOR THE DETERMINATION OF THE BIOACTIVITY, PREDICTIVE PHARMACOKINETICS AND POTENTIAL IMMUNOGENICITY OF THERAP…

2021

The critical quality attributes of a given biotherapeutic monoclonal antibody (mAb), its molecular characterization, functional assessment and effector function analysis should be defined and profiled in detail during the life cycle of a biotherapeutic drug. In the past, this product characterization was simple and standardized. In today’s complex world of biologics, success demands a more thoughtful approach and drug developers are investing in advanced analytics much earlier in the development process. Indeed, investing in selected sophisticated and state of the art analytics in early developmental phases of a therapeutic monoclonal antibody may mitigate risks by confirming that the drug …

Inside Cover: Exploiting Reaction‐Diffusion Conditions to Trigger Pathway Complexity in the Growth of a MOF (Angew. Chem. Int. Ed. 29/2021)

2021

Thermodiffusion anisotropy under a magnetic field in ionic liquid-based ferrofluids

2021

International audience; Ferrofluids based on maghemite nanoparticles (NPs), typically 10 nm in diameter, are dispersed in an ionic liquid (1-ethyl 3-methylimidazolium bistriflimide - EMIM-TFSI). The average interparticle interaction is found to be repulsive by small angle scattering of X-rays and of neutrons, with a second virial coefficient A2 = 7.3. A moderately concentrated sample at Φ = 5.95 vol% is probed by forced Rayleigh scattering under an applied magnetic field (up to H = 100 kA m-1) from room temperature up to T = 460 K. Irrespective of the values of H and T, the NPs in this study are always found to migrate towards the cold region. The in-field anisotropy of the mass diffusion c…

Computing variations of entropy and redundancy under nonlinear mappings not preserving the signal dimension: quantifying the efficiency of V1 cortex

2021

In computational neuroscience, the Efficient Coding Hypothesis argues that the neural organization comes from the optimization of information-theoretic goals [Barlow Proc.Nat.Phys.Lab.59]. A way to confirm this requires the analysis of the statistical performance of biological systems that have not been statistically optimized [Renart et al. Science10, Malo&Laparra Neur.Comp.10, Foster JOSA18, Gomez-Villa&Malo J.Neurophysiol.19]. However, when analyzing the information-theoretic performance, cortical magnification in the retina-cortex pathway poses a theoretical problem. Cortical magnification stands for the increase the signal dimensionality [Cowey&Rolls Exp. Brain Res.74]. Conventional mo…

Emergence in 2017-2019 of novel reassortant equine-like G3 rotavirus strains in Palermo, Sicily.

2021

Rotavirus A (RVA) is a major etiologic agent of gastroenteritis in children worldwide. Hospital-based surveillance of viral gastroenteritis in paediatric population in Palermo (Italy) from 2017 onwards revealed a sharp increase in G3P[8] RVAs, accounting for 71% of all the RVAs detected in 2019. This pattern had not been observed before in Italy, with G3 RVA usually being detected at rates lower than 3%. In order to investigate this unique epidemiological pattern, the genetic diversity of G3 RVAs identified during a 16-year long surveillance (2004-2019) was explored by systematic sequencing of the VP7 and VP4 genes and by whole genome sequencing of selected G3 strains, representative of the…

Advanced characterization of a fully human IgG1 therapeutic monoclonal antibody by structure-activity relationship studies

2021

Constitution de corpus thématique : Pour un meilleur suivi du territoire de la Métropole de Montpellier Méditerranée

2021

International audience

Collecte, visualisation et analyse de données viaires géohistoriques

2021

International audience; Les villes sont des territoires complexes qu’il est possible d’appréhender de multiples manières.L’angle d’étude retenu dans la recherche présentée ici est celui morphologique, et plus particulièrement celui lié à la forme des réseaux viaires. Les mécanismes d’évolution de tels réseaux au cours du temps sont complexes et leur modélisation, nécessitant une approche transdisciplinaire, en est à ses premiers pas. La compréhension de leurs dynamiqu es d’évolution comporte de forts enjeux : cela permet de mieux appréhender l’utilisation d’un territoire et son organisation, etégalement de mieux imaginer ses perspectives de développement.Ainsi, Le projet COVADEO.a pour obje…

Enhanced Modelling for Extended Performance Analysis of Interior Permanent Magnet Synchronous Machine Drive fed with Cascaded H-Bridges Multilevel In…

2021

This paper presents a comparative simulation analysis of an Interior Permanent Magnet Synchronous Machine (IPMSM) performance once fed by a traditional three-phase two-level inverter and then using a three-phase five-level Cascaded H-Bridges Multilevel Inverter (CHBMI). For this purpose, an enhanced mathematical model of the IPMSM, that take into account simultaneously saturation, cross-coupling, spatial harmonics and iron loss effects, has been employed. Furthermore, two different PWM modulation strategies have been considered. The study was conducted for several working conditions, evaluating the impact of CHBMI adoption on the IPMSM performance in terms of improved efficiency and torque …

ΛK femtoscopy in Pb-Pb collisions at √sNN = 2.76 TeV

2021

The first measurements of the scattering parameters of ΛK pairs in all three charge combinations (ΛK+, ΛK−, and ΛK0S) are presented. The results are achieved through a femtoscopic analysis of ΛK correlations in Pb-Pb collisions at √sNN=2.76 TeV recorded by ALICE at the Large Hadron Collider. The femtoscopic correlations result from strong final-state interactions and are fit with a parametrization allowing for both the characterization of the pair emission source and the measurement of the scattering parameters for the particle pairs. Extensive studies with the THERMINATOR 2 event generator provide a good description of the nonfemtoscopic background, which results mainly from collective eff…