showing 36 of ~574560 from 574555 documents
FOLFIRINEC: a randomized phase II trial of mFOLFIRINOX vs platinum-etoposide for metastatic neuroendocrine carcinoma of gastroenteropancreatic or unk…
2021
Abstract Background Poorly differentiated neuroendocrine carcinomas (NEC) are rare diseases with a poor prognosis. Platinum-etoposide (PE) has been the recommended first-line treatment for decades. FOLFIRINEC (NCT04325425) is a national multicenter randomized phase II study which aims to challenge this standard regimen. Methods The primary objective is to compare the median progression-free survival (PFS) under mFOLFIRINOX versus PE. The secondary objectives are to evaluate the objective response rates (ORR), median overall survival (OS), safety and quality of life. The associated real-time translational study will establish a molecular profile for each patient enrolled. Main inclusion crit…
Un antecedente imprescindible del Valle de los Caídos: la aportación de Manuel Abril en 1939
2021
En abril de 1939 veía la luz un artículo firmado por el crítico de arte Manuel Abril en el que abogaba por la existencia de un monumento para celebrar la victoria de la guerra y honrar a sus caídos. En esa misma fecha se dictó el decreto que disponía la erección de un monumento para perpetuar el recuerdo a los muertos en la Cruzada de Liberación, lo que supuso el primer paso para la construcción del Valle de los Caídos. Las coincidencias conceptuales y plásticas entre ambos monumentos, el propuesto y el ejecutado, son más que notorias. Es propósito de este trabajo ponerlas de manifiesto dentro del contexto histórico y conceder a la aportación de Abril la categoría de antecedente del monumen…
Técnicas, modelos y transferencia en la ingeniería de puentes de la Cuba decimonónica. 1800-1860
2021
El fomento de las obras públicas como recurso de desarrollo económico y comercial tiene en la Cuba decimonónica uno de sus ejemplos nacionales más destacados. En este proceso, la implementación de la tecnología de la nueva era industrial introdujo en la isla nuevas referencias que tuvieron un impacto destacable en varios ámbitos constructivos. Este trabajo tiene como objetivo proyectar este análisis sobre la evolución de la ingeniería de puentes de los dos primeros tercios del siglo XIX. Mediante la documentación de varios proyectos, algunos inéditos, se identifican cuáles fueron sus modelos de referencia, sus vías de introducción y los canales de transferencia que tuvieron lugar a partir d…
‘Human rights and democracy are not self-evident’ : Finnish student teachers’ perceptions on democracy and human rights education
2021
This article discusses democracy and human rights education (DHRE) in Finnish teacher education, drawing on existing literature, curricula and a survey of student teachers’ perceptions. Earlier studies suggested that DHRE in Finnish teacher education is unsystematic, implicit, and dependent on the teacher’s individual interests. These studies highlight a sense of national exceptionalism, where DHRE is assumed to be self-evident. In 2019, we conducted a survey of student teachers (n=300) in one university. Data content analysis reveals that student teachers now see DHRE as relevant and timely, and by no means self-evident. Student teachers believe that DHRE needs to be explicit and part of t…
La estirpe albanesa de la Virgen del Refugio de la Trinidad sobre un viejo icono casi olvidado
2021
Este estudio investiga sobre el estado actual y el misterioso origen de un icono muy antiguo conservado en el Monasterio de la Trinidad de Valencia y su vinculación con Donica Adrianiti, esposa de Giorgio Castriota (Gjergj Kastrioti) Scanderbeg, considerado héroe nacional de Albania; también sobre la presencia y estancia de esta noble dama en Valencia en relación con la reina Juana de Nápoles, hermana de Fernando el Católico.
Niveaux, tendances et facteurs explicatifs de la non-utilisation de la contraception moderne par les femmes exposées au risque de grossesse non désir…
2021
Guinea is one of the West African countries where fertility is still high and declining little, with a worrying health situation (maternal and infant mortality levels among the highest in the world). The level of demographic growth (2.5% per year on average) associated with the low level of socioeconomic development of the country seems difficult to reconcile with the satisfaction of the objectives of sustainable development and thus makes the control of fertility a major challenge.Despite the political will displayed since the early 1980s, the adoption of a national population policy declaration in 1992 and a reproductive health policy in 2001 and the Government's efforts to promote Family…
A Comparative Study of Top-Down and Bottom-Up Carbon Nanodots and Their Interaction with Mercury Ions
2021
We report a study of carbon dots produced via bottom-up and top-down routes, carried out through a multi-technique approach based on steady-state fluorescence and absorption, time-resolved fluorescence spectroscopy, Raman spectroscopy, infrared spectroscopy, and atomic force microscopy. Our study focuses on a side-to-side comparison of the fundamental structural and optical properties of the two families of fluorescent nanoparticles, and on their interaction pathways with mercury ions, which we use as a probe of surface emissive chromophores. Comparison between the two families of carbon dots, and between carbon dots subjected to different functionalization procedures, readily identifies a …
Estimation of selected skin parameters during a series of beauty treatments in women with acne: a pilot study
2021
Background: Acne vulgaris occurs most often in young people and can significantly decrease the quality of life. Properly selected dermatological therapy and cosmetic procedures can effectively improve the skin condition of acne patients. Aim of the study: The aim of this study was to examine how various cosmetics treatments affect facial sebum levels, skin hydration, and desquamation in young women with acne vulgaris. Material and Methods: 101 women with acne aged 19–29 (M = 22.5 years, SD = 2.3 years) were included in the study. The following cosmetic treatments were used over a 12-week period: intensive pulsing light, alpha-hydroxy acids, cavitation peeling, non-needle mesotherapy, diamon…
Erratum: Diagnosis and Management of Vaccine-Related Thrombosis following AstraZeneca COVID-19 Vaccination: Guidance Statement from the GTH.
2021
Finnish L2 proficiency for working life : towards research-based language education and supervision practices
2021
In all Nordic countries, the L2 proficiency needed at work has become a key area in the language education provided for adult immigrants. This paper is part of a series of articles that gives an overview of language policies and research activities in the Nordic countries related to L2 in working life, together with a presentation of novel empirical analyses. Here, the focus is on the Finnish perspective. The aims of this paper are twofold. First, it provides an overall picture of the policies and research findings underlying recent tendencies in Finnish L2 language education in/for working life. After this, the article presents two case studies of clinical supervision practices in health c…
Brokerage from within: A conceptual framework
2021
Situated between various social worlds, brokers are highly mobile figures, in a physical and an ideational sense; they channel scarce information and resources, translate different languages and jargons, and mediate and facilitate between individuals and/or organisations, the local and the global, in a wide range of settings. Taking an in-depth ethnographic look at the actual work of brokers and their particular life stories, contributions to this special issue examine brokers’ successes and failures, their vulnerabilities and limitations, (changing) interests and motivations within the cultural contexts that these brokers are part of. By adopting a comparative perspective in a thematic an…
The Anti-Samaritan Attitude as Reflected in Rabbinic Midrashim
2021
Samaritans, as a group within the ranges of ancient ‘Judaisms’, are often mentioned in Talmud and Midrash. As comparable social–religious entities, they are regarded ambivalently by the rabbis. First, they were viewed as Jews, but from the end of the Tannaitic times, and especially after the Bar Kokhba revolt, they were perceived as non-Jews, not reliable about different fields of Halakhic concern. Rabbinic writings reflect on this change in attitude and describe a long ongoing conflict and a growing anti-Samaritan attitude. This article analyzes several dialogues between rabbis and Samaritans transmitted in the Midrash on the book of Genesis, Bereshit Rabbah. In four larger sections, the f…
Learning IFRS through MOOC: student and graduate perceptions
2021
This paper provides an overview of the perceptions held by 623 Colombian students and graduates regarding the learning of IFRS through a MOOC. Data was collected through an online survey and the re...
“… al estilo de Inglaterra según la última moda”. Figurines ingleses. Edición para España 1824-25 de Rudolph Ackermann
2021
Desde el último tercio del siglo XVIII, las estampas de figurines relacionadas directamente con la apariencia, el gusto y la moda, difundidas desde la prensa, tienen en España una especial significación a la hora de orientar a las élites urbanas e ilustradas. Se trataba, en definitiva, de estar al día de las novedades y adelantos que se producían en todos aquellos objetos y elementos destinados a priorizar el estatus y la elegancia conforme a los dictados que se gestaban en las grandes capitales europeas que marcaban las pautas de la distinción. Londres y lo inglés, junto a los figurines parisinos, comenzó a formar parte de los criterios estéticos de la alta sociedad española, que participó…
Error-Free Affine, Unitary, and Probabilistic OBDDs
2021
We introduce the affine OBDD model and show that zero-error affine OBDDs can be exponentially narrower than bounded-error unitary and probabilistic OBDDs on certain problems. Moreover, we show that Las-Vegas unitary and probabilistic OBDDs can be quadratically narrower than deterministic OBDDs. We also obtain the same results for the automata counterparts of these models.
Persistence of temperature and precipitation: from local to global anomalies
2021
Using detrended fluctuation analysis (DFA) we find that all continents are persistent in temperature. The scaling exponents of the southern hemisphere (SH) continents, i.e., South America (0.77) and Oceania (0.72) are somewhat higher than scaling exponents of Europe (0.70), Asia (0.69) and North America (0.64), but the scaling of Africa is by far the highest (0.86). The reason for this is the location of Africa near the equator. The scaling exponents of the precipitation are much smaller, i.e. between 0.55 (Europe) and 0.68 (North America). The scaling exponent of Europe is near that of the random noise (0.5), while the other continents are slightly persistent in precipitation. We also show…
El ocaso de un gremio: San Eloy de Santiago de Compostela en el siglo XIX
2021
El presente artículo tiene como objetivo la reconstrucción de la historia del gremio de San Eloy de Santiago de Compostela en el siglo XIX, tema sobre el que todavía no existe ningún estudio. La metodología de nuestra investigación se ha centrado en primer lugar en analizar la bibliografía publicada sobre la desintegración del sistema gremial en España, motivada por el paradigma filosófico de la Ilustración y la liberalización del trabajo. Para aplicarlo al caso de Compostela y en concreto a los plateros, el segundo paso fue el vaciado de los libros consistoriales y las matrículas industriales del Archivo Histórico Universitario de Santiago, fuentes complementadas por los Anuarios de Comerc…
El testamento de la marquesa del Ràfol. Concepción Castellví (1783-1847), un testimonio desconocido del coleccionismo artístico a principios del sigl…
2021
María de la Concepción Castellví y Cardona, marquesa del Ràfol, falleció en 1847 dejando una gran fortuna: vínculos patrimoniales en explotación, junto a bienes muebles, plata, alhajas, su biblioteca y una importante colección pictórica. La marquesa pertenecía a la más antigua nobleza valenciana vinculada a los círculos ilustrados y a instituciones como la Real Academia de Bellas Artes de San Carlos de València. Ella misma fue gran aficionada a la pintura e ingresó como académica de mérito en la entidad a la que legó algunas obras. En su testamento nombró administrador a José María Vera dando orden de que a su muerte se formalizara «un escrupuloso inventario y justiprecio de todos sus biene…
Energetic demands and nutritional strategies of elite cross-country skiers during Tour de Ski : A narrative review
2021
The Tour de Ski (TDS: 6–9 sprint and distance races across 9–11 days) represents the most intense competition series of the cross-country (XC) ski season and is characterized by accumulated stress from consecutive days of high-intensity (~ 85%–160% VO2max) racing, travel, cold temperatures and low to moderate altitude (500–1500 m above sea level). Here, nutritional strategies play a key supportive role for optimized health, recovery and performance. This narrative review aims to provide an evidence-based discussion on the energetic demands of the TDS and recommendations for nutritional strategies to optimize health and performance of XC skiers during and following the TDS. We highlight seve…
La Sala Parpalló y su contribución a la fotografía en Valencia (1980-1995)
2021
La historia de la fotografía ha reservado una parte importante a plasmar la lucha por lograr la consideración artística del medio. Sin embargo, poco se han tenido en cuenta los intereses de aquellos quienes escriben los discursos que trascienden, y más en un ámbito de carácter local. El objetivo de este artículo es perfilar un panorama general sobre el horizonte expositivo valenciano en el ámbito de lo fotográfico, tomando como caso particular la Sala Parpalló, espacio inaugurado en 1980 y dirigido por Artur Heras hasta 1995. Para ello, partiremos de un contexto más amplio hasta llegar a comprender la importancia que esta sala tuvo a nviel nacional, consolidándose como pionera en muchos de …
El Departament d'Història de l'Art en el curso 2019-2020
2021
Memoria anual
New insights into submarine tailing disposal for a reduced environmental footprint: Lessons learnt from Norwegian fjords
2021
Submarine tailing disposal (STD) in fjords from land-based mines is common practice in Norway and takes place in other regions worldwide. We synthesize the results of a multidisciplinary programme on environmental impacts of STDs in Norwegian fjords, providing new knowledge that can be applied to assess and mitigate impact of tailing disposal globally, both for submarine and deep-sea activities. Detailed geological seafloor mapping provided data on natural sedimentation to monitor depositional processes on the seafloor. Modelling and analytical techniques were used to assess the behaviour of tailing particles and process-chemicals in the environment, providing novel tools for monitoring. To…
Aproximación al higienismo en la arquitectura de Rafael Guastavino
2021
La obra de Rafael Guastavino Moreno (1842-1908) está vinculada habitualmente a la construcción con bóveda tabicada, un sistema constructivo tradicional originario del Levante peninsular que este arquitecto combinó con el mortero de cemento para erigir un gran número de edificios de muy diverso tipo tanto en Barcelona como posteriormente en Estados Unidos. Sin embargo, estos autores han defendido en otras ocasiones la versatilidad de Guastavino como arquitecto y hasta qué punto la bóveda tabicada no supuso en un principio el cuaderno de bitácora único ni principal para su trayectoria profesional. La bóveda tabicada representó una herramienta más en la panoplia de sus habilidades, entre las c…
Crítica social en La noche de los muertos vivientes y su remake: aportaciones al rol de la mujer en el cine de terror.
2021
Tradicionalmente se ha tenido la percepción de que la mujer en el cine de terror a ocupado un rol pasivo que le llevaba a asumir, casi siempre, el papel de víctima, subyugada en todo momento a los personajes masculinos del texto fílmico. Por este motivo el cine de terror es concebido de forma habitual como un género culturalmente dominado y consumido por hombres, producido por una industria que victimiza y castiga a la mujer una y otra vez. Partiendo de esta premisa y aprovechando la crítica de corte sociopolítico presente en La noche de los muertos vivientes (Night of the Living Dead, George A. Romero, 1968) y su remake del año 1990, nos planteamos un análisis de la crítica elaborada por R…
Survival Prediction in Intrahepatic Cholangiocarcinoma: A Proof of Concept Study Using Artificial Intelligence for Risk Assessment
2021
Several scoring systems have been devised to objectively predict survival for patients with intrahepatic cholangiocellular carcinoma (ICC) and support treatment stratification, but they have failed external validation. The aim of the present study was to improve prognostication using an artificial intelligence-based approach. We retrospectively identified 417 patients with ICC who were referred to our tertiary care center between 1997 and 2018. Of these, 293 met the inclusion criteria. Established risk factors served as input nodes for an artificial neural network (ANN). We compared the performance of the trained model to the most widely used conventional scoring system, the Fudan score. Pr…
Símbolos en el atuendo de las mujeres mayas de la antigüedad. Una aproximación iconográfica a tres diseños singulares
2021
Este artículo forma parte de una investigación de mayor envergadura que tiene como objeto de estudio la representación femenina en el arte maya a través de los elementos que conforman sus retratos y definen sus identidades. Tanto las joyas, como la pintura corporal, los tocados o las prendas de vestir, establecían un diálogo con el espectador de su tiempo que si se analiza e interpreta en la actualidad, también puede aproximar al investigador al conocimiento sobre sus portadoras. Por ello, en esta ocasión presentamos concretamente el análisis de tres símbolos que forman parte de la indumentaria de algunas mujeres de la élite maya, entre los cuales cabe destacar el que luce la noble Señora …
Determination of the LD50 with the chick embryo chorioallantoic membrane (CAM) assay as a promising alternative in nanotoxicological evaluation
2021
Toxicity tests in rodents are still considered a controversial topic concerning their ethical justifiability. The chick embryo chorioallantoic membrane (CAM) assay may offer a simple and inexpensive alternative. The CAM assay is easy to perform and has low bureaucratic hurdles. At the same time, the CAM assay allows the application of a broad variety of analytical methods in the field of nanotoxicological research. We evaluated the CAM assay as a methodology for the determination of nanotoxicity. Therefore we calculated the median lethal dose (LD50), performed in vivo microscopy and immunohistochemistry to identify organ-specific accumulation profiles, potential organ damage, and the kineti…
A comprehensive RNA-Seq-based gene expression atlas of the summer squash (Cucurbita pepo) provides insights into fruit morphology and ripening mechan…
2021
[EN] Background Summer squash (Cucurbita pepo: Cucurbitaceae) are a popular horticultural crop for which there is insufficient genomic and transcriptomic information. Gene expression atlases are crucial for the identification of genes expressed in different tissues at various plant developmental stages. Here, we present the first comprehensive gene expression atlas for a summer squash cultivar, including transcripts obtained from seeds, shoots, leaf stem, young and developed leaves, male and female flowers, fruits of seven developmental stages, as well as primary and lateral roots. Results In total, 27,868 genes and 2352 novel transcripts were annotated from these 16 tissues, with over 18,0…
Strong BV-extension and W1,1-extension domains
2021
We show that a bounded domain in a Euclidean space is a $W^{1,1}$-extension domain if and only if it is a strong $BV$-extension domain. In the planar case, bounded and strong $BV$-extension domains are shown to be exactly those $BV$-extension domains for which the set $\partial\Omega \setminus \bigcup_{i} \overline{\Omega}_i$ is purely $1$-unrectifiable, where $\Omega_i$ are the open connected components of $\mathbb{R}^2\setminus\overline{\Omega}$.
Entrepreneurship and Resilience in Spanish Sports Clubs: A Cluster Analysis.
2021
Entrepreneurial orientation can be an effective response by sports clubs to manage a recession, such as the COVID-19 crisis. Therefore, its study can be fundamental to understand different ways of managing a recession. This study analyzes the entrepreneurial orientation of Spanish non-profit sports clubs to identify different groups and their profiles. The sample is composed of 145 Spanish non-profit sports clubs. Different validated scales have been used to analyze entrepreneurial orientation, business model adaptation, service quality, and economic and social performance (performance in social impact and performance in social causes). Entrepreneurial orientation is the variable used to di…
Lack of evidence for infectious SARS-CoV-2 in feces and sewage
2021
Purpose: The SARS-CoV-2 coronavirus is a respiratory virus whose primary route of transmission is airborne. However, it has been shown that the virus can replicate in gastrointestinal cells, can be excreted in feces, and can reach sewage systems. Although viral RNA is known to be found in patient feces and sewage, little is known about the possible fecal-oral transmission of the coronavirus. Determining the presence of infective viral particles in feces and sewage is necessary to take adequate control measures and to discover new routes of coronavirus transmission. Here, we analyzed feces and urine of COVID-19 patients and wastewater samples at the time of high prevalence in the region unde…
Time spent on the smartphone does not relate to manual dexterity in young adults.
2021
Abstract Background The Grooved Pegboard Test (GPT) is widely adopted to evaluate manual dexterity, it presents normative data but the test is influenced by different factors. The influence of time spent on smartphones has not been considered before, for this reason, the objective of this study was to evaluate if smartphone use influences the time to complete the GPT. A total of 38 (21 women; 17 men) young adults 20.7 (1.5) years participated in the study. The time spent on the smartphones during the last seven days was recorded through the device itself and the GPT performance was measured. A correlation analysis between the time spent on the smartphone and GPT was performed while the t-te…
Alien plant invasions in Mediterranean habitats: an assessment for Sicily
2021
AbstractLevels of plant invasions in different habitat types were assessed in several regional studies, but few of them were from the Mediterranean. Here we compare the levels of vascular plant invasion across habitats and plant communities of Sicily. We used a large dataset of plant species presences/absences in vegetation plots to analyze the invasion patterns across habitats considering biogeography, life form and phenology of alien plants. Vegetation plots were classified based on the EUNIS classification of European habitats. The invasiveness of each species was expressed in terms of its absolute and percentage frequency. Representation of different life forms and phenological patterns…
Transitioning towards a Sustainable Wellbeing Economy—Implications for Rural–Urban Relations
2021
This article focuses on the question of how a shift from a narrow economic perspective to a wider sustainable wellbeing focus in regional development strategies and actions might change rural–urban relations. A brief review of relevant research and discourses about economic development models provides the foundation for the analysis. The review leads to the development of an analytical framework that puts the notion of sustainable wellbeing at its center. The criteria included in the analytical framework are then used to assess the current situation, challenges and perceived ways forward based on data and analyses from 11 European regions. The focus of the analysis is on different exp…
Draft genome sequence and biofilm production of a carbapenemase-producing Klebsiella pneumoniae (KpR405) sequence type 405 strain isolated in Italy
2021
Rapid identification and characterization of multidrug-resistant Klebsiella pneumoniae strains is essential to diagnose severe infections in patients. In clinical routine practice, K. pneumoniae is frequently identified and characterized for outbreak investigation. Pulsed-field gel electrophoresis or multilocus sequence typing could be used, but, unfortunately, these methods are time-consuming, laborious, expensive, and do not provide any information about the presence of resistance and virulence genes. In recent years, the decreasing cost of next-generation sequencing and its easy use have led to it being considered a useful method, not only for outbreak surveillance but also for rapid ide…
false
2021
Recent studies on the economic dimensions of sports and physical activity in Germany have revealed that sport-related tourism is one of the important contributors to private household consumption. Due to a lack of representative and large-scale data sets, this topic has never been displayed in detail before. By using computer assisted telephone and web interviews, we collected a total data set of n=19,396 persons living in Germany. The expenditures for active sport tourism were isolated, which is understood as travelling to take part in different sporting activities. Data are provided on the overall spending of German households for sport trips, with skiing (€ 3.4 bn) and scuba diving (€ 2.…