showing 36 of ~574560 from 574555 documents
Measurements of Sigma(+) and Sigma(-) time-like electromagnetic form factors for center-of-mass energies from 2.3864 to 3.0200 GeV
2021
Physics letters / B 814, 136110 (2021). doi:10.1016/j.physletb.2021.136110
Role of Levo-tetrahydropalmatine and its metabolites for management of chronic pain and opioid use disorders.
2021
Abstract Background Opioids have been prescribed to reduce suffering from pain and to enhance quality of life. Due to the addictive potential and the lack of other effective alternatives to treat severe acute and chronic pains, opioids remain a serious public health issue. While, opioids directly influence the drug-seeking behavior, tolerance and withdrawal processes, through neuroadaptation, the brain's endogenous opioid system also adapts in the presence of chronic pain and could contribute to the difficulty of treatment. Despite the seemingly obvious interaction between the presence of pain and opioid-abuse, little is known about the underlying mechanisms in the brain. Purpose To review …
Function of AtPGAP1 in GPI anchor lipid remodeling and transport to the cell surface of GPI-anchored proteins
2021
ABSTRACTGPI-anchored proteins (GPI-APs) play an important role in a variety of plant biological processes including growth, stress response, morphogenesis, signalling and cell wall biosynthesis. The GPI-anchor contains a lipid-linked glycan backbone that is synthesized in the endoplasmic reticulum (ER) where it is subsequently transferred to the C-terminus of proteins containing a GPI signal peptide by a GPI transamidase. Once the GPI anchor is attached to the protein, the glycan and lipid moieties are remodelled. In mammals and yeast, this remodelling is required for GPI-APs to be included in Coat Protein II (COPII) coated vesicles for their ER export and subsequent transport to the cell s…
COVID-19 Y SU REPERCUSIÓN EN LAS ADICCIONES
2021
espanolObjetivo. Indagar acerca de la literatura cientifica emergente a nivel internacional sobre la repercusion de la pandemia por COVID-19 en las adicciones. Metodologia. La base de datos Web of Science se utilizo para analizar la literatura cientifica sobre la pandemia por COVID-19 y la influencia que esta pueda tener en el ambito de las adicciones. Resultados. Se identificaron 320 documentos, de los cuales 38 cumplieron los criterios de inclusion. Sobresalieron tres problematicas: el consumo de tabaco, opioides y alcohol. Segun la literatura incipiente, entre los consumidores de opiaceos existe el riesgo de aumento de las sobredosis, asi como un empeoramiento del binomio estres-alcohol …
Developing a matrix framework for protein transition towards more sustainable diets
2021
PurposeThe purpose of this study is to propose a matrix framework to understand the interdependencies of domains and scales of protein transition towards diets based on plants and alternative sources of proteins.Design/methodology/approachThe abductive research approach is used in building the framework, and the proposed framework is illustrated using the regional food system in Central Finland as an example. Focus groups and interviews were used to collect qualitative data from 28 respondents.FindingsThis study provides a framework for protein transition, with five domains and five scale levels. Interactions between public and private governance activities at different scales, domains and …
Rapid parameter estimation of discrete decaying signals using autoencoder networks
2021
Machine learning: science and technology 2(4), 045024 (2021). doi:10.1088/2632-2153/ac1eea
A Gravitational-wave Measurement of the Hubble Constant Following the Second Observing Run of Advanced LIGO and Virgo
2021
This paper presents the gravitational-wave measurement of the Hubble constant (H 0) using the detections from the first and second observing runs of the Advanced LIGO and Virgo detector network. The presence of the transient electromagnetic counterpart of the binary neutron star GW170817 led to the first standard-siren measurement of H 0. Here we additionally use binary black hole detections in conjunction with galaxy catalogs and report a joint measurement. Our updated measurement is H 0 = km s-1 Mpc-1 (68.3% of the highest density posterior interval with a flat-in-log prior) which is an improvement by a factor of 1.04 (about 4%) over the GW170817-only value of km s-1 Mpc-1. A significant …
Citizen consultations on science communication: A citizen science approach
2021
La ciencia ciutadana forma part d’una tendencia cientifica i social mes amplia que promou el dialeg bidireccional i la implicacio dels cientifics i el public a forca d’involucrar la ciutadania en el proces d’investigacio. Aquest article examina els esforcos de CONCISE (un projecte internacional en el qual participen Espanya, Italia, Portugal, Polonia i Eslovaquia) per a comprendre, mitjancant consultes publiques, com adquireix i utilitza la informacio cientifica la ciutadania. Les consultes, celebrades en 2019, van incloure prop de 500 persones. CONCISE intenta posar la participacio de la ciutadania en el centre del proces d’investigacio demanant-li suggeriments sobre com millorar la comuni…
false
2021
Phylogeny, biogeography and systematics of Dysphanieae (Amaranthaceae)
2021
After a rather turbulent taxonomic history, Dysphanieae (Chenopodioideae, Amaranthaceae) were established to contain five genera, four of which are monospecific (Cycloloma, Neomonolepis, Suckleya, Teloxys) and geographically restricted, and the fifth genus, Dysphania, having a nearly worldwide distribution and comprising ca. 50 species. This study investigates the phylogeny, biogeography and taxonomy of Dysphanieae. We studied specimens from 32 herbaria to infer morphological differences and distribution areas of the species and sampled 121 accessions representing 39 accepted species of the tribe for molecular phylogenetic analyses. The molecular phylogeny tested generic relationships of th…
A multi-phase multi-objective dynamic genome-scale model shows different redox balancing among yeast species in fermentation
2021
ABSTRACTYeasts constitute over 1500 species with great potential for biotechnology. Still, the yeastSaccharomyces cerevisiaedominates industrial applications and many alternative physiological capabilities of lesser-known yeasts are not being fully exploited. While comparative genomics receives substantial attention, little is known about yeasts’ metabolic specificity in batch cultures. Here we propose a multi-phase multi-objective dynamic genome-scale model of yeast batch cultures that describes the uptake of carbon and nitrogen sources and the production of primary and secondary metabolites. The model integrates a specific metabolic reconstruction, based on the consensus Yeast8, and a kin…
A photoswitchable helical peptide with light-controllable interface / transmembrane topology in lipidic membranes
2021
AbstractAccording to the three-step model, the spontaneous insertion and folding of helical transmembrane (TM) polypeptides into lipid bilayers is driven by three sequential equilibria: solution-to-membrane interface (MI) partition, unstructured-to-helical folding, and MI-to-TM helix insertion. However, understanding these three steps with molecular detail has been challenged by the lack of suitable experimental approaches to rapidly and reversibly perturb membrane-bound hydrophobic polypeptides out of equilibrium. Here, we report on a 24-residues-long hydrophobic α-helical polypeptide, covalently coupled to an azobenzene photoswitch (KCALP-azo), which displays a light-controllable TM/MI eq…
Analysis of Brain Functions in Men with Prostate Cancer under Androgen Deprivation Therapy: A One-Year Longitudinal Study.
2021
The relationship between cognitive decline and androgen deprivation therapy (ADT) under luteinizing hormone-releasing hormone (LHRH) analogues is unclear, and there is a scarcity of longitudinal studies considering the interaction between cognition, depressive symptoms and sleep quality in men with prostate cancer (PCa) treated with ADT. This study aimed to determine if there were differences in the scores obtained in cognitive assessment, depressive symptoms, and sleep quality after one year of ADT and determine the interrelations between sleep, mood, and cognitive status. A prospective longitudinal observational study was designed, in which a cohort of men (mean age was 70.8 years) newly …
Centre procedural volume and adverse in‐hospital outcomes in patients undergoing percutaneous transvenous edge‐to‐edge mitral valve repair usingMitra…
2021
AIMS The number of transcatheter mitral valve repair (TMVr) procedures has increased substantially during the last years. A better understanding of the relationship between hospital volume of transcatheter transvenous mitral valve repairs using MitraClip® and patient outcomes may provide information for future policy decisions to improve patient management. METHODS AND RESULTS We analysed patient characteristics and in-hospital outcomes for all TMVr procedures using MitraClip® performed in Germany from 2011 to 2017. Hospitals were stratified according to centre volumes and patients were compared for baseline characteristics and adverse in-hospital events. Overall, 24 709 inpatients were tre…
false
2021
Abstract. The formation of ice in clouds is an important processes in mixed-phase and ice-phase clouds. Yet, the representation of ice formation in numerical models is highly uncertain. In the last decade, several new parameterizations for heterogeneous freezing have been proposed. However, it is currently unclear what the effect of choosing one parameterization over another is in the context of numerical weather prediction. We conducted high-resolution simulations (Δx=250 m) of moderately deep convective clouds (cloud top ∼-18 ∘C) over the southwestern United Kingdom using several formulations of ice formation and compared the resulting changes in cloud field properties to the spread of an…
Symmetry meets AI
2021
We explore whether Neural Networks (NNs) can {\it discover} the presence of symmetries as they learn to perform a task. For this, we train hundreds of NNs on a {\it decoy task} based on well-controlled Physics templates, where no information on symmetry is provided. We use the output from the last hidden layer of all these NNs, projected to fewer dimensions, as the input for a symmetry classification task, and show that information on symmetry had indeed been identified by the original NN without guidance. As an interdisciplinary application of this procedure, we identify the presence and level of symmetry in artistic paintings from different styles such as those of Picasso, Pollock and Van…
Increased Stability of Polysaccharide/Silica Hybrid Sub‐Millicarriers for Retarded Release of Hydrophilic Substances
2021
Proceedings from the 9th European Congress of Methodology
2021
Este libro recoge algunos de los trabajos presentados en el 9º Congreso Europeo de Metodología. Este congreso se ocupa del desarrollo y aplicación de metodologías de investigación en los campos de Ciencias sociales, Comportamentales, de Salud, Educativas, Económicas y de Evaluación. This book collects some of the papers presented at the 9th European Congress of Methodology. This congress is devoted to the development and application of research methods in the Behavioral, Social, Educational, Health and Economic and Evaluation fields.
Migration experience and mental health: A qualitative study in France and Brazil
2021
Background:The relationship between migration and mental health is complex and involves factors at different levels, as the individual history of the migrant, the collective history of their home country, the host society’s and their mutual past history. Even though the migratory scenario of France and Brazil has changed over the years, both countries currently host an important number of immigrants.Aim:The main objective of the present study was to describe and analyze the impacts of the migratory experience on mental health of migrants with different migration experiences and living in two countries: France and Brazil.Method:Semi-structured interviews were conducted with 13 participants, …
Stationary subspace analysis based on second-order statistics
2021
In stationary subspace analysis (SSA) one assumes that the observable p-variate time series is a linear mixture of a k-variate nonstationary time series and a (p-k)-variate stationary time series. The aim is then to estimate the unmixing matrix which transforms the observed multivariate time series onto stationary and nonstationary components. In the classical approach multivariate data are projected onto stationary and nonstationary subspaces by minimizing a Kullback-Leibler divergence between Gaussian distributions, and the method only detects nonstationarities in the first two moments. In this paper we consider SSA in a more general multivariate time series setting and propose SSA method…
On the informative role of Reward-based Crowdfunding
2021
Spin accumulation from nonequilibrium first principles methods
2021
For the technologically relevant spin Hall effect, most theoretical approaches rely on the evaluation of the spin-conductivity tensor. In contrast, for most experimental configurations the generation of spin accumulation at interfaces and surfaces is the relevant quantity. Here, we directly calculate the accumulation of spins due to the spin Hall effect at the surface of a thin metallic layer, making quantitative predictions for different materials. Two distinct limits are considered, both relying on a fully relativistic Korringa-Kohn-Rostoker density functional theory method. In the semiclassical approach, we use the Boltzmann transport formalism and compare it directly with a fully quantu…
Aspectos de la transformación de las cooperativas de crédito 1tras la Ley de Modificaciones Estructurales de 2009
2021
espanolLa Ley 3/2009 sobre modificaciones estructurales de las sociedades mercantiles ha modificado la ley de cooperativas de credito con el fin de regular ciertos aspectos de la transformacion de estas entidades, y en particular el destino que debe darse a su Fondo de reserva obligatorio en esos procesos, que debera integrarse en el capital social de la nueva entidad. El presente trabajo analiza la transformacion como modificacion estructural a disposicion de las cooperativas y en particular de las cooperativas de credito; su reconocimiento en la ley y en la jurisprudencia espanola, a lo largo del tiempo; la problematica juridica que plantea y en particular, el destino de su Fondo de reser…
Mesocarnivore community structuring in the presence of Africa's apex predator
2021
This work was supported by the Peace Parks Foundation; G.C.S. was funded by a doctoral grant from Fundacão para a Ciência e a Tecnologia (FCT: PD/BD/114037/2015); L.H.S. was supported by the National Research Foundation, South Africa (UID: 107099 and 115040) and by the African Institute for Conservation Ecology. Apex predator reintroductions have proliferated across southern Africa, yet their ecological effects and proposed umbrella benefits of associated management lack empirical evaluations. Despite a rich theory on top-down ecosystem regulation via mesopredator suppression, a knowledge gap exists relating to the influence of lions (Panthera leo) over Africa's diverse mesocarnivore (less …
"3D Printed Complexed Arota as A Preoperative Guidance and Postoperative Results’ Evaluation"
2021
We describe a case of 55 years old female who underwent an aortic valve replacement using a mechanical valve...
Bayesian Analysis of Population Health Data
2021
The analysis of population-wide datasets can provide insight on the health status of large populations so that public health officials can make data-driven decisions. The analysis of such datasets often requires highly parameterized models with different types of fixed and random effects to account for risk factors, spatial and temporal variations, multilevel effects and other sources on uncertainty. To illustrate the potential of Bayesian hierarchical models, a dataset of about 500,000 inhabitants released by the Polish National Health Fund containing information about ischemic stroke incidence for a 2-year period is analyzed using different types of models. Spatial logistic regression and…
Three‐Component Castagnoli‐Cushman Reaction of 3‐Arylglutaconic Acid Anhydrides, Carbonyl Compounds, and Ammonium Acetate: a Quick and Flexible Way t…
2021
Sperm kinematic subpopulations of the American crocodile (Crocodylus acutus)
2021
There has been very limited use of computer assisted semen analysis (CASA) to evaluate reptile sperm. The aim of this study was to examine sperm kinematic variables in American crocodile (Crocodylus acutus) semen samples and to assess whether sperm subpopulations could be characterized. Eight ejaculates (two ejaculates/male) from four sexually mature captive crocodiles were obtained. An ISAS®v1 CASA-Mot system, with an image acquisition rate of 50 Hz, and ISAS®D4C20 counting chambers were used for sperm analyses. The percentages of motile and progressively motile spermatozoa did not differ among animals (P > 0.05) but there was a significant animal effect with regards to kinematic variables…
false
2021
The development of digital solutions is becoming increasingly important in facing global challenges. Therefore, research on this topic is important in taking into account cardiac patients’ experiences of the rehabilitation process for the design of digital counseling solutions. The aim of the present qualitative study was to explore the different meanings that patients give to the rehabilitation process using a Glaserian grounded theory (GT) approach. Qualitative interviews were conducted with 30 participants from a rehabilitation center in Finland. The findings indicated a “complex trust-building process” core category comprising five categories of trust-building in rehabilitation: feeling…
Green Deal et PAC : quelle compatibilité ?
2021
The June 2018 CAP proposals are only marginally consistent with the ambitions of the Green Deal. This is also the case of the regulation revisions being adopted by either the Council or the European Parliament in October 2020. Making EU agriculture consistent with the Green Deal but would require a whole food chain policy that encompasses more stringent instruments on the supply side and extensive changes in eating patterns.
Trace Element Concentration and Stable Isotope Ratio Analysis in Blueberries and Bilberries: A Tool for Quality and Authenticity Control
2021
Vaccinium genus berries—wild bilberries (Vaccinium myrtillus L.) and cultivated highbush blueberries (Vaccinium corymbosum L.)—are consumed worldwide, and their consumption has a trend of stable increase. Thus, considering their wide use in ethnomedicine, for juice and jam production, as functional food, as well as their use in preparations of extracts which have application potential in pharmaceutical and cosmetics industries, studies regarding the composition of these berries are of special importance. The aim of this study is to characterise the elemental and isotopic composition, as well as variation in element concentration in bilberries gathered from different sites in Northern Europe…
Network governance arrangements and rural-urban synergy
2021
Increasing attention has been paid to the importance of balanced rural–urban interaction to sustainable regional development. Yet, our knowledge on the elements of network governance for such interaction is scarce. The aim of this paper is to study what kind of network governance arrangements currently exist, how they can be improved, and whether evolutionary governance paths can be identified. We analyse five existing and evolving cases of functioning rural–urban interaction in European Union (EU) member states, using a network governance framework as an analytical lens. We supplement the governance analysis with examining what kind of spatial understanding or combination of di…
Olympic Legacy: Status of Research
2021
There is no doubt that the topic of legacy of sport events is becoming one of the critical issues in professional sports worldwide. Taxpayers’ money is used to support the staging of events and the...
Association between xerostomia, oral and general health, and obesity in adults. A cross-sectional pilot study.
2021
Background The objective of this study was to analyse the association between oral and general health variables and obesity indicators with the sensation of dry mouth or xerostomia as evaluated on the Xerostomia Inventory (XI). Material and Methods A total of 354 randomly selected subjects participated in this cross-sectional pilot study and completed an anonymous questionnaire. Anthropometric, clinical, and xerostomic variables were evaluated. Kruskal-Wallis, ANOVA and Bonferroni test were used for multiple comparisons. ROC curves and multinomial logistic regression were used to determine the (OR) risk of xerostomia. Results A total of 30.7 % of respondents reported xerostomia based on XI.…
Nonlinear pulse shaping : a versatile tool for ultrafast photonics and a building block of nonlinear fiber dynamics
2021
International audience
Analysis of composition, morphology, and biosynthesis of cuticular wax in wild type bilberry (Vaccinium myrtillus L.) and its glossy mutant
2021
Abstract In this study, cuticular wax load, its chemical composition, and biosynthesis, was studied during development of wild type (WT) bilberry fruit and its natural glossy type (GT) mutant. GT fruit cuticular wax load was comparable with WT fruits. In both, the proportion of triterpenoids decreased during fruit development concomitant with increasing proportions of total aliphatic compounds. In GT fruit, a higher proportion of triterpenoids in cuticular wax was accompanied by a lower proportion of fatty acids and ketones compared to WT fruit as well as lower density of crystalloid structures on berry surfaces. Our results suggest that the glossy phenotype could be caused by the absence o…