showing 36 of ~574560 from 574555 documents
Letter to the editor
2021
Aventures de la serviette. Pour une sémiotique des manières de table
2021
Au cours de ces dernières années, la sémiotique de la nourriture a connu un grand développement. En suivant les maîtres dans ce domaine (de Jakobson à Lévi-Strauss, de Barthes à Greimas, de Fabbri à Landowski et à Boutaud3), de nombreux travaux ont été effectués concernant les recettes de cuisine et les régimes alimentaires, la structure des plats et la conception des aliments, les récits gastronomiques et les valeurs gustatives, les processus esthétiques et les extases de saveurs, les langages de dégustation et les modes médiatiques. Mais, tout en tenant compte des suggestions issues de ces recherches, on doit constater que beaucoup de travail reste encore à faire.
Sex-related differences in D-dimer levels for venous thromboembolism screening.
2021
Background D-dimer is generally considered positive above 0.5 mg/L irrespective of sex. However, women have been shown to be more likely to have a positive D-dimer after controlling for other factors. Thus, differences may exist between males and females for using D-dimer as a marker of venous thromboembolic (VTE) disease. We hypothesized that the accuracy of D-dimer tests may be enhanced by using appropriate cutoff values that reflect sex-related differences in D-dimer levels. Methods This research is a secondary analysis of a multicenter, international, prospective, observational study of adult (18+ years) patients suspected of VTE, with low-to-intermediate pretest probability based on We…
Perceived stress in relation to quality of life and resilience in patients with advanced chronic kidney disease undergoing hemodialysis
2021
Background: Patients with chronic kidney disease undergo various stages of therapeutic adaptation which involve lifestyle modifications, physical changes, and adjustment to renal replacement therapy. This process produces adaptive stress. Objective: To identify how resilience, health- related quality of life, and sociodemographic, clinical, and hemodialysis routine-related variables are related to perceived stress in patients with chronic kidney disease receiving hemodialysis for more than six months. Methods: This was a multicenter and cross-sectional study involving 144 patients from the Valencian Community (Spain). The assessment scales used for the study were the Perceived Stress Scale …
Exploring weed suppression in intercrops using the FLORSYS model
2021
International audience; Presentation by Nathalie Colbach describing the FLORSYS model and how it is used to model the interactions and relative impacts on weed flora when using a range of example intercrops, delivered as part of the Winter School hosted by Wageningen University between 11-15 January 2021 and linked to the ReMIX postgraduate course “Role of species mixtures in controlling diseases, pests and weeds and alleviating associated yield reductions, conferring resilience to stresses and improving ecosystem service provision”
Detection of Hypoxanthine from Inosine and Unusual Hydrolysis of Immunosuppressive Drug Azathioprine through the Formation of a Diruthenium(III) Syst…
2021
Hypoxanthine (hpx) is an important molecule for both biochemistry research and biomedical applications. It is involved in several biological processes associated to energy and purine metabolism and has been proposed as a biomarker for a variety of disease states. Consequently, the discovery and development of systems suitable for the detection of hypoxanthine is pretty appealing in this research field. Thus, we have obtained a stable diruthenium (III) compound in its dehydrated and hydrated forms with formula [{Ru(µ
Tailoring the anomalous Hall effect of SrRuO$_3$ thin films by strain: a first principles study
2021
Motivated by the recently observed unconventional Hall effect in ultra-thin films of ferromagnetic SrRuO$_3$ (SRO) we investigate the effect of strain-induced oxygen octahedral distortion in the electronic structure and anomalous Hall response of the SRO ultra-thin films by virtue of density functional theory calculations. Our findings reveal that the ferromagnetic SRO films grown on SrTiO$_3$ (in-plane strain of $-$0.47$\%$) have an orthorhombic (both tilting and rotation) distorted structure and with an increasing amount of substrate-induced compressive strain the octahedral tilting angle is found to be suppressed gradually, with SRO films grown on NdGaO$_3$ (in-plane strain of $-$1.7$\%$…
Indirect Selection against Antibiotic Resistance via Specialized Plasmid-Dependent Bacteriophages
2021
Antibiotic resistance genes of important Gram-negative bacterial pathogens are residing in mobile genetic elements such as conjugative plasmids. These elements rapidly disperse between cells when antibiotics are present and hence our continuous use of antimicrobials selects for elements that often harbor multiple resistance genes. Plasmid-dependent (or male-specific or, in some cases, pilus-dependent) bacteriophages are bacterial viruses that infect specifically bacteria that carry certain plasmids. The introduction of these specialized phages into a plasmid-abundant bacterial community has many beneficial effects from an anthropocentric viewpoint: the majority of the plasmids are lost whil…
Stackelberg Game Theory Based Energy Management Systems in the Presence of Renewable Energy Sources
2021
The game theory concept has been adapted for energy management between energy producers and consumers in the presence of renewable energy sources (RES) and electric vehicles (EVs). The objective of...
Quality of life of NEET youth in comparative perspective: subjective well-being during the transition to adulthood
2021
In this study, we examine the self-reported subjective well-being (SWB) of youth who are ‘not in employment, education or training’ (NEET) across 24 countries in Europe. Theorizing from a youth tra...
Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer.
2021
Abstract In tumor-bearing mice, cyclic fasting or fasting-mimicking diets (FMD) enhance the activity of antineoplastic treatments by modulating systemic metabolism and boosting antitumor immunity. Here we conducted a clinical trial to investigate the safety and biological effects of cyclic, five-day FMD in combination with standard antitumor therapies. In 101 patients, the FMD was safe, feasible, and resulted in a consistent decrease of blood glucose and growth factor concentration, thus recapitulating metabolic changes that mediate fasting/FMD anticancer effects in preclinical experiments. Integrated transcriptomic and deep-phenotyping analyses revealed that FMD profoundly reshapes antican…
Conflict, consent, dissensus: The unfinished as challenge to politics and planning
2021
Public participation in planning politics is a legal right in many countries. Planners often see themselves as the defenders of public interests, whereas planning studies may see public planning as the institutionalization of politics, the politicized management or government of disputes on planning issues. Public participation is ultimately a political decision, and this article focuses on how phrases like planning is ‘a work in progress’ and agonistic consensus is a ‘solution for now’ in fact add a critical issue to planning politics: such statements indicate that planning should be seen as an unfinished process, and decisions as temporary. A ‘solution for now’ literally means a ‘planning…
A Set of Cell Lines Derived from a Genetic Murine Glioblastoma Model Recapitulates Molecular and Morphological Characteristics of Human Tumors
2021
Simple Summary Glioblastoma (GBM) is a highly aggressive and almost inevitably lethal brain tumor. Animal models for GBM are crucial to study how the tumor evolves in vivo and to test novel treatment options. Most currently available models are based on the transplantation of human GBM cells into mice with a defective immune system. However, this approach does not allow to study the contribution of immune cells to GBM growth and to test immunotherapies. Transplantation of murine GBM cells overcomes this limitation, however, up to now, only a limited number, which mostly do not mimic important characteristics of human GBM, have been available. Via in vivo passaging, we established a set of m…
Pre‐instrumental summer precipitation variability in northwestern Greece from a high‐elevation Pinus heldreichii network
2021
The spatiotemporal variability of precipitation is of vital importance to Mediterranean ecology and economy, but pre‐instrumental changes are not well understood. Here, we present a millennial‐length June–July precipitation reconstruction derived from a network of 22 Pinus heldreichii high‐elevation sites in the Pindus Mountains of northwestern Greece. Tree‐ring width chronologies from these sites cohere exceptionally well over the past several hundred years (r1467–2015 = 0.64) revealing coherence at inter‐annual to centennial timescales across the network. The network mean calibrates significantly against instrumental June–July precipitation over the past 40 years (r1976–2015 = 0.71), even…
Les langages de l'humour
2021
International audience
How can dementia and disability be prevented in older adults: where are we today and where are we going?
2021
Abstract Ageing of the population, together with population growth, has brought along an ample increase in the number of older individuals living with dementia and disabilities. Dementia is the main cause of disability in old age, and promoting healthy brain ageing is considered as a key element in diminishing the burden of age‐related disabilities. The World Health Organization recently launched the first risk reduction guidelines for cognitive impairment and dementia. According to recent estimates, approximately 40% of dementia cases worldwide could be attributable to 12 modifiable risk factors: low education; midlife hypertension and obesity; diabetes, smoking, excessive alcohol use, phy…
Diurnal cortisol secretion and health-related quality of life in healthy older people
2021
Abstract Several studies have demonstrated that a dysregulated hypothalamic-pituitary-adrenal (HPA) axis is related to worse health status (e.g., depression, posttraumatic stress, or diabetes, among others). However, less is known about the association between the individual's perception of their own health status and HPA-axis functioning in healthy older people. The aim of the present study was to examine the relationship between HPA-axis functioning and health-related quality of life (HRQoL) in healthy older people. To do this, 140 healthy older people (69 men and 71 women) from 56 to 76 years old collected eight saliva samples on two consecutive weekdays to measure the diurnal cortisol c…
P2D: a self-supervised method for depth estimation from polarimetry
2021
Monocular depth estimation is a recurring subject in the field of computer vision. Its ability to describe scenes via a depth map while reducing the constraints related to the formulation of perspective geometry tends to favor its use. However, despite the constant improvement of algorithms, most methods exploit only colorimetric information. Consequently, robustness to events to which the modality is not sensitive to, like specularity or transparency, is neglected. In response to this phenomenon, we propose using polarimetry as an input for a self-supervised monodepth network. Therefore, we propose exploiting polarization cues to encourage accurate reconstruction of scenes. Furthermore, we…
2K7P
2021
Promoting Food Waste Reduction at Primary Schools. A Case Study
2021
Food waste (FW) has recently attracted the interest of different institutions and has been the focus of many studies due to its important environmental, social and economic impact. This paper aims to analyze whether a didactic intervention, consisting of informing teachers and pupils and involving pupils in reducing FW, could bring about changes in the level of knowledge and attitude towards FW and in the amount of FW generated during the mid-morning break and lunch at schools. This study was conducted at a public Primary School in Valencia (Spain). Subtle changes in the level of knowledge and attitude towards FW were detected in teachers and pupils after the intervention. Around 30% of FW …
The HisClima database: historical weather logs for automatic transcription and information extraction
2021
Knowing the weather and atmospheric conditions from the past can help weather researchers to generate models like the ones used to predict how weather conditions are likely to change as global temperatures continue to rise. Many historical weather records are available from the past registered on a systemic basis. Historical weather logs were registered in ships, when they were on the high seas, recording daily weather conditions such as: wind speed, temperature, coordinates, etc. These historical documents represent an important source of knowledge with valuable information to extract climatic information of several centuries ago. This paper presents a database for researching about the ca…
Long-term prognostic implications of revascularization in patients with known or suspected chronic coronary syndromes without ischemia in vasodilator…
2021
In this study, we evaluated the association between symptoms-guided revascularization occurred within three months following a negative vasodilator stress cardiovascular magnetic resonance (negative stress-CMR) and long-term adverse events in patients with known or suspected chronic coronary syndrome (CCS).We retrospectively evaluated 3517 patients in which the stress first-pass perfusion imaging revealed no ischemia. The primary endpoint was the composite of death, spontaneous myocardial infarction, heart failure (HF), or stroke. The association between symptoms-guided revascularization after a negative stress-CMR and the endpoint was assessed using the multivariable Cox proportional hazar…
A search for neutron to mirror-neutron oscillations using the nEDM apparatus at PSI
2021
It has been proposed that there could be a mirror copy of the standard model particles, restoring the parity symmetry in the weak interaction on the global level. Oscillations between a neutral standard model particle, such as the neutron, and its mirror counterpart could potentially answer various standing issues in physics today. Astrophysical studies and terrestrial experiments led by ultracold neutron storage measurements have investigated neutron to mirror-neutron oscillations and imposed constraints on the theoretical parameters. Recently, further analysis of these ultracold neutron storage experiments has yielded statistically significant anomalous signals that may be interpreted as …
Regulatory Functions of MicroRNAs in Cancer Pathogenesis
2021
Abstract- MicroRNAs (miRNAs) are a large family of evolutionary conserved small non-coding RNA molecules that firstly discovered in 1993. They regulate gene expression of about 50% of protein-coding genes at the post-transcriptional level. MiRNAs can target numerous messenger RNAs and subsequent misexpression of them can affect many different signaling pathways. They are playing a pivotal role in cancer development by regulation of the genes expression which involved in the proliferation, survival, differentiation, apoptosis or metastasis of the cancer cells. Several treatment approaches such as inhibition of oncomiRs and restoration of tumor suppressor miRNAs have been established in certa…
OmniFlowNet: a Perspective Neural Network Adaptation for Optical Flow Estimation in Omnidirectional Images
2021
International audience; Spherical cameras and the latest image processing techniques open up new horizons. In particular, methods based on Convolutional Neural Networks (CNNs) now give excellent results for optical flow estimation on perspective images. However, these approaches are highly dependent on their architectures and training datasets. This paper proposes to benefit from years of improvement in perspective images optical flow estimation and to apply it to omnidirectional ones without training on new datasets. Our network, OmniFlowNet, is built on a CNN specialized in perspective images. Its convolution operation is adapted to be consistent with the equirectangular projection. Teste…
Evolution des pratiques de soins dans les services de psychiatrie publique
2021
The document proposes a methodological device and some theoretical approaches to build a sociology of clinical practices in the "poles" (basic territorial units) of adult public psychiatry in France, based on a qualitative and quantitative exploratory survey in seven sites. It shows that the territorial offer of care presents aspects of homogenization throughout France: a decline of psychotherapies in favour of a myriad of "psychic interventions", the generalized development of eclecticism and pragmatism. However, the range of care on offer remains diversified both technically and ethically. In addition to the history of each site and the ideology of its leader, these differences are relate…
Non-Redundant tRNA Reference Sequences for Deep Sequencing Analysis of tRNA Abundance and Epitranscriptomic RNA Modifications
2021
Analysis of RNA by deep-sequencing approaches has found widespread application in modern biology. In addition to measurements of RNA abundance under various physiological conditions, such techniques are now widely used for mapping and quantification of RNA modifications. Transfer RNA (tRNA) molecules are among the frequent targets of such investigation, since they contain multiple modified residues. However, the major challenge in tRNA examination is related to a large number of duplicated and point-mutated genes encoding those RNA molecules. Moreover, the existence of multiple isoacceptors/isodecoders complicates both the analysis and read mapping. Existing databases for tRNA sequencing pr…
Deep Learning Network for Segmentation of the Prostate Gland With Median Lobe Enlargement in T2-weighted MR Images: Comparison With Manual Segmentati…
2021
Purpose: Aim of this study was to evaluate a fully automated deep learning network named Efficient Neural Network (ENet) for segmentation of prostate gland with median lobe enlargement compared to manual segmentation. Materials and Methods: One-hundred-three patients with median lobe enlargement on prostate MRI were retrospectively included. Ellipsoid formula, manual segmentation and automatic segmentation were used for prostate volume estimation using T2 weighted MRI images. ENet was used for automatic segmentation; it is a deep learning network developed for fast inference and high accuracy in augmented reality and automotive scenarios. Student t-test was performed to compare prostate vol…
A deep learning approach for the segmentation of myocardial diseases
2021
Cardiac left ventricular (LV) segmentation is a paramount essential step for both diagnosis and treatment of cardiac pathologies such as ischemia, myocardial infarction, arrhythmia and myocarditis. However, this segmentation is challenging due to high variability across patients and the potential lack of contrast between structures. In this work, we propose and evaluate a (2.5D) SegU-Net model based on the fusion of two deep learning segmentation techniques (U-Net and Seg-Net) for automated LGE-MRI (Late gadolinium enhanced magnetic resonance imaging) myocardial disease (infarct core and no-reflow region) quantification in a new multifield expert annotated dataset. Given that the scar tissu…
Incorporating depth information into few-shot semantic segmentation
2021
International audience; Few-shot segmentation presents a significant challengefor semantic scene understanding under limited supervision.Namely, this task targets at generalizing the segmentationability of the model to new categories given a few samples.In order to obtain complete scene information, we extend theRGB-centric methods to take advantage of complementary depthinformation. In this paper, we propose a two-stream deep neuralnetwork based on metric learning. Our method, known as RDNet,learns class-specific prototype representations within RGB anddepth embedding spaces, respectively. The learned prototypesprovide effective semantic guidance on the corresponding RGBand depth query ima…
Antimicrobial prophylaxis in patients with immune thrombocytopenia treated with rituximab: a retrospective multicenter analysis
2021
The primary aim of this study was to describe the use of primary anti-infective prophylaxis (AP) in common clinical practice in patients affected by immune thrombocytopenia (ITP) and treated with RTX. Population studied consisted of patients affected by ITP (age ≥ 18 years) who had received at least one dose of RTX from January 2008 to June 2018. Five Italian haematology centres participated in the current study. Data were retrospectively collected: demographic data (age, gender), concomitant comorbidities and previous therapies for ITP, characteristics of AP, the occurrence of infections and their management. The ITP cohort consisted of 67 patients sub-grouped into two categories according…
Multiscale Attention-Based Prototypical Network For Few-Shot Semantic Segmentation
2021
International audience; Deep learning-based image understanding techniques require a large number of labeled images for training. Few-shot semantic segmentation, on the contrary, aims at generalizing the segmentation ability of the model to new categories given only a few labeled samples. To tackle this problem, we propose a novel prototypical network (MAPnet) with multiscale feature attention. To fully exploit the representative features of target classes, we firstly extract rich contextual information of labeled support images via a multiscale feature enhancement module. The learned prototypes from support features provide further semantic guidance on the query image. Then we adaptively i…
Polarimetric image augmentation
2021
Robotics applications in urban environments are subject to obstacles that exhibit specular reflections hampering autonomous navigation. On the other hand, these reflections are highly polarized and this extra information can successfully be used to segment the specular areas. In nature, polarized light is obtained by reflection or scattering. Deep Convolutional Neural Networks (DCNNs) have shown excellent segmentation results, but require a significant amount of data to achieve best performances. The lack of data is usually overcomed by using augmentation methods. However, unlike RGB images, polarization images are not only scalar (intensity) images and standard augmentation techniques cann…
Unstructural Biology of TRP Ion Channels: The Role of Intrinsically Disordered Regions in Channel Function and Regulation
2021
The first genuine high-resolution single particle cryo-electron microscopy structure of a membrane protein determined was a transient receptor potential (TRP) ion channel, TRPV1, in 2013. This methodical breakthrough opened up a whole new world for structural biology and ion channel aficionados alike. TRP channels capture the imagination due to the sheer endless number of tasks they carry out in all aspects of animal physiology. To date, structures of at least one representative member of each of the six mammalian TRP channel subfamilies as well as of a few non-mammalian families have been determined. These structures were instrumental for a better understanding of TRP channel function and …
Sandbar shark aggregation in the central Mediterranean Sea and potential effects of tourism
2021
An aggregation of sandbar sharks Carcharhinus plumbeus occurs every summer around the remote uninhabited islet of Lampione (Pelagie Islands Marine Protected Area, south-western Mediterranean Sea), attracting an increasing number of tourists for a shark watching experience. Despite the ecological and socio-economic importance of this rare occurrence in Mediterranean waters, there is a lack of scientific data and lack of information as to the potential impact of tourist activities on the presence and behaviour of this shark species. Using baited underwater videos, this study provides the first assessment of this shark aggregation, as well as a preliminary evaluation of the potential effects t…
Unveiling the Unexpected Reactivity of Electrophilic Diazoalkanes in [3+2] Cycloaddition Reactions within Molecular Electron Density Theory
2021
The [3+2] cycloaddition (32CA) reactions of strongly nucleophilic norbornadiene (NBD), with simplest diazoalkane (DAA) and three DAAs of increased electrophilicity, have been studied within the Molecular Electron Density Theory (MEDT) at the MPWB1K/6-311G (d,p) computational level. These pmr-type 32CA reactions follow an asynchronous one-step mechanism with activation enthalpies ranging from 17.7 to 27.9 kcal·