showing 36 of ~574560 from 574555 documents
Non-Redundant tRNA Reference Sequences for Deep Sequencing Analysis of tRNA Abundance and Epitranscriptomic RNA Modifications
2021
Analysis of RNA by deep-sequencing approaches has found widespread application in modern biology. In addition to measurements of RNA abundance under various physiological conditions, such techniques are now widely used for mapping and quantification of RNA modifications. Transfer RNA (tRNA) molecules are among the frequent targets of such investigation, since they contain multiple modified residues. However, the major challenge in tRNA examination is related to a large number of duplicated and point-mutated genes encoding those RNA molecules. Moreover, the existence of multiple isoacceptors/isodecoders complicates both the analysis and read mapping. Existing databases for tRNA sequencing pr…
Unveiling the Unexpected Reactivity of Electrophilic Diazoalkanes in [3+2] Cycloaddition Reactions within Molecular Electron Density Theory
2021
The [3+2] cycloaddition (32CA) reactions of strongly nucleophilic norbornadiene (NBD), with simplest diazoalkane (DAA) and three DAAs of increased electrophilicity, have been studied within the Molecular Electron Density Theory (MEDT) at the MPWB1K/6-311G (d,p) computational level. These pmr-type 32CA reactions follow an asynchronous one-step mechanism with activation enthalpies ranging from 17.7 to 27.9 kcal·
Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials
2021
Medicinal mushrooms have important health benefits and exhibit a broad spectrum of pharmacological activities, including antiallergic, antibacterial, antifungal, anti-inflammatory, antioxidative, antiviral, cytotoxic, immunomodulating, antidepressive, antihyperlipidemic, antidiabetic, digestive, hepatoprotective, neuroprotective, nephroprotective, osteoprotective, and hypotensive activities. The growing interest in mycotherapy requires a strong commitment from the scientific community to expand clinical trials and to propose supplements of safe origin and genetic purity. Bioactive compounds of selected medicinal mushrooms and their effects and mechanisms in in vitro and in vivo clinical stu…
Freirismo, desigualdad social y educativa
2021
Este artículo pretende dar respuesta a las siguientes cuestiones: ¿Por qué el presidente de Brasil, J. Bolsonaro, criticó la presencia de freiristas en la universidad? ¿Qué enuncia el freirismo que merezca el reproche de la primera autoridad de la república?¿Por qué sobrevive el freirismo? Para ello, se elabora un argumento genera, a partir de pruebas matemáticas, que pone el acento en la vigencia y en la centralidad de la desigualdad educativa, que Freire ya había desvelado y denunciado en la expresión de “pedagogía del oprimido”.
 This article seeks to answer the following questions: Why did the president of Brazil, J. Bolsonaro, criticize the presence of Freiristas in the university…
The Multifaced Role of STAT3 in Cancer and Its Implication for Anticancer Therapy
2021
Signal transducer and activator of transcription (STAT) 3 is one of the most complex regulators of transcription. Constitutive activation of STAT3 has been reported in many types of tumors and depends on mechanisms such as hyperactivation of receptors for pro-oncogenic cytokines and growth factors, loss of negative regulation, and excessive cytokine stimulation. In contrast, somatic STAT3 mutations are less frequent in cancer. Several oncogenic targets of STAT3 have been recently identified such as c-myc, c-Jun, PLK-1, Pim1/2, Bcl-2, VEGF, bFGF, and Cten, and inhibitors of STAT3 have been developed for cancer prevention and treatment. However, despite the oncogenic role of STAT3 having been…
25 años de la presencia de Paulo Freire en tierras valencianas...De la esperanza a la espera
2021
Se ofrece un estudio que permite contextualizar la conferencia que impartió Paulo Freire en Valencia en marzo de 1995, hace veinticinco años. Se realiza una aproximación a algunos de los hechos mediante una historia de vida elaborada a partir de experiencia vivida como director del seminario junto a las personas ponentes en esas jornadas de trabajo y con la suma de la importante documentación existente: programas, textos, fotografías, agendas, anotaciones, copias de escritos oficiales y oficiosos... Freire pronunció su conferencia dentro de un seminario que tuvo un gran éxito, al que se inscribieron más de 700 personas y que supuso un acontecimiento de primer orden en la historia educativa …
Notes sobre el seminari internacional "La importancia estratègica de la formació de les persones adultes" organitzat per la UIMP a Castelló
2021
Aquest text és un exercici de memòria que recrea els moments viscuts en abril de 1995, com assistent al seminari internacional de la UIMP La importància estratégica de la Formació de Persones Adultes, en la jornada Castelló. Aquella participació va donar l´oportunitat, no sols d´escoltar la conferència de Frerire, però de poder conversar amb Basil Bernstein al finalitzar la seua ponència, com un dels conferenciants convidats. El present text recupera per primera vegada l´entrevista de l´autor amb Berstein sobre el discurs pedagògic en relació amb l´educació de persones adultes.
 Este texto es un ejercicio de memoria que recrea los momentos vividos en abril de 1995, como asistente al se…
Dialogando con Joan Romero González sobre Paulo Freire: El valor transformador de la educación, la formación permanente y a lo largo de la vida
2021
En esta entrevista, realizamos junto al Prof. Dr. Joan Romero González un recorrido por el pensamiento de Freire y sus ideas pedagógicas, las cuales analizaremos cuestionando nuestra realidad actual y las influencias freireanas que podemos encontrar en nuestros días.
A Cluster based Sensor-Selection Scheme for Energy-Efficient Agriculture Sensor Networks
2021
Improving the energy-efficiency of remotely deployed sensor nodes in agriculture wireless networks is very challenging due to a lack of access to energy grid. Network clustering and limiting the amount of sensor data are among the various methods to improve the lifetime of these sensor nodes. In this work, an optimal sensor-selection scheme is proposed to improve the Quality of Service in clustered agriculture networks. the proposed method selects a limited number of sensor nodes to be active in each cluster. It considers the estimator performance while selecting limited sensor nodes for environmental monitoring. the optimal sensor-selection process considers the information of remaining en…
Palabras para Paulo Freire. Saludos locales e internacionales
2021
Palabras para paulo Freire. Saludos locales e internacionales Palavras para Paulo Freire. Saudações locais e internacionais Words for Paulo Freire. Local and international greetings
Biodegradable Polymers for the Production of Nets for Agricultural Product Packaging
2021
It is well known that the need for more environmentally friendly materials concerns, among other fields, the food packaging industry. This regards also, for instance, nets used for agricultural product (e.g., citrus fruits, potatoes) packaging. These nets are typically manufactured by film blowing technique, with subsequent slicing of the films and cold drawing of the obtained strips, made from traditional, non-biodegradable polymer systems. In this work, two biodegradable polymer systems were characterized from rheological, processability, and mechanical points of view, in order to evaluate their suitability to replace polyethylene-based polymer systems typically used for agricultural prod…
Perspectiva contemporânea das ideas de Paulo Freire
2021
O pensamento pedagógico de Paulo Freire, revelando ser a educação dialógica uma questão essencial para uma maior leitura crítica da realidade, continua inspirando pedagogos/as, filósofos/as e sociólogos/as da educação de diferentes contextos, como forma de responder aos questionamentos e desafios das realidades emergentes, nas dimensões educativa, política e social da práxis pedagógica. A atualização do seu pensamento inspira este artigo guiado pelo seguinte questionamento: Como, em um mundo multicultural, se revelam, de forma atualizada as ideias de Freire, tendo como arcabouço pedagógico e político o diálogo? A partir de fontes documental-bibliográficas, utilizando uma abordagem descritiv…
Nuevos enfoques sobre la transferencia de conocimiento en Educación. Reseña de Santos Rego, Miguel A. (Ed). (2020). La transferencia de conocimiento …
2021
Reseña de Santos Rego, Miguel A. (Ed). (2020). La transferencia de conocimiento en Educación. Un desafío estratégico. Madrid: Narcea.
Un viatge didàctic a la sociologia de l'Educació. Ressenya de Ramón Albert, Anna (2019). Las aventuras del mundo social. Un viaje a la Sociología de …
2021
Ressenya de la publicacio d'Anna Ramon: Las aventuras del mundo social. Un viaje a la Sociologia de la Educacion. Un material didactico para estudiantes elaborado por una estudiante. Valencia: Tirant lo Blanch.
Da pedagogia do oprimido à pedagogia do reconhec¡mento : Um diálogo entre o pensamento de Paulo Freire e Axel Honneth
2021
O presente artigo teórico coloca em tela um tema pouco discutido no cenário brasileiro, que é fruto do diálogo da obra de Paulo Freire e Axel Honneth. Assim, este trabalho discorre acerca de aspectos nucleares do pensamento dos autores, como Amorosidade, Práxis e Solidariedade, Amor e Direito. Também evidenciamos que os autores trabalham com a mesma perspectiva de denúncia/negação da situação de exclusão/opressão dos sujeitos, os quais são traduzidos por eles como Oprimidos e Desprezo. Assim, propomos uma leitura teórica e crítica que caminha para uma pedagogia do oprimido e da esperança para uma pedagogia do reconhecimento, mostrando como os elementos teóricos e as categorias propostas por…
La última conversación con Paulo Freire
2021
La última conversación con Paulo Freire
La vida de las palabras. Un diálogo posible entre Paulo Freire y Martin Heidegger
2021
Este artículo sugiere un hipotético diálogo entre Paulo Freire y Martin Heidegger. Ambos pensadores y educadores recuperan y recrean tradiciones filosóficas y educativas propias, abriendo una rica conversación con las voces del pasado, del presente y también del futuro. Cada uno de ellos ha inspirado una literatura abundante y creciente. Lo que no es frecuente, sino más bien excepcional, es encontrar referencias sobre los dos pensadores al mismo tiempo. Este texto pretende compensar esa ausencia. Al mismo tiempo, rinde homenaje al pedagogo brasileño, destacando la vigencia de su obra y la necesidad de reinventarla, así como anticipando su reconocimiento como patrimonio intangible de la huma…
Presencia de Paulo Freire : Piezas de vida
2021

 Hace veinticinco años, en 1995, Paulo Freire impartió una Conferencia en la sede de la Universidad Internacional Menéndez Pelayo (UIMP) de la ciudad de València. Fue invitado por la Conselleria de Educación y por la Mesa de los Agentes Sociales para la Formación Permanente de Adultos a impartir la conferencia inaugural en unas jornadas denominadas La importancia estratégica de la Formación de las Personas Adultas. Estas jornadas se impartieron consecutivamente en las ciudades de Valencia, Castellón y Alicante con motivo de la aprobación de la Ley Valenciana de Formación de Personas Adultas. La presencia de Paulo Freire en Valencia constituyó un acontecimiento histórico que merece se…
Determinants of interest in extended-released buprenorphine: A survey among 366 French patients treated with buprenorphine or methadone
2021
International audience; Aim: To explore the factors determining the interest in extended-release buprenorphine (XR-BUP) injections among patients receiving opioid agonist treatment (OAT) in France.Methods: 366 patients receiving OAT for opioid use disorder, recruited in 66 French centers, were interviewed from 12/2018 to 05/2019. A structured questionnaire assessed their interest in XR-BUP using a [1-10] Likert scale. 'More' vs. 'less' interested groups were defined using the median score of interest, and their characteristics were explored using adjusted odds ratios (aORs) and 95 % confidence interval (95 %CI). Independent variables were as follows: sociodemographic characteristics, OAT-re…
2021-$H_0$ Odyssey: Closed, Phantom and Interacting Dark Energy Cosmologies
2021
Up-to-date cosmological data analyses have shown that \textit{(a)} a closed universe is preferred by the Planck data at more than $99\%$ CL, and \textit{(b)} interacting scenarios offer a very compelling solution to the Hubble constant tension. In light of these two recent appealing scenarios, we consider here an interacting dark matter-dark energy model with a non-zero spatial curvature component and a freely varying dark energy equation of state in both the quintessential and phantom regimes. When considering Cosmic Microwave Background data only, a phantom and closed universe can perfectly alleviate the Hubble tension, without the necessity of a coupling among the dark sectors. Accountin…
Hexamorphism of Dantrolene: Insight into the Crystal Structures, Stability, and Phase Transformations
2021
Dantrolene represents yet another interesting example of abundant molecular crystal polymorphism existing in at least six different neat polymorphs, three of which can be obtained via crystallizati...
Parental Teaching of Reading and Spelling Across the Transition From Kindergarten to Grade 1
2021
We investigated the longitudinal links between parental teaching of reading and spelling and children’s word reading and spelling skills. Data of 244 Lithuanian parent–child dyads were analyzed, who were followed across three time points: end of kindergarten (T1; Mage = 6.88; 116 girls), beginning of Grade 1 (T2), and end of Grade 1 (T3). The children’s word reading and spelling skills were tested, and the parents answered questionnaires on the frequency with which they taught their children reading and spelling. Overall, the results showed that the parents were responsive to their children’s skill levels across the domains of reading and spelling and across time (i.e., the transition from …
[Rt or RDt, that is the question!]
2021
The article compares two of the most followed indices in the monitoring of COVID-19 epidemic cases: the Rt and the RDt indices. The first was disseminated by the Italian National Institute of Health (ISS) and the second, which is more usable due to the lower difficulty of calculation and the availability of data, was adopted by various regional and local institutions. The rationale for the Rt index refers to that for the R0 index, the basic reproduction number, which is used by infectivologists as a measure of contagiousness of a given infectious agent in a completely susceptible population. The RDt index, on the other hand, is borrowed from the techniques of time series analysis for the tr…
Therapeutic Strategies To Counteract Antibiotic Resistance in MRSA Biofilm‐Associated Infections
2021
Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as one of the leading causes of persistent human infections. This pathogen is widespread and is able to colonize asymptomatically about a third of the population, causing moderate to severe infections. It is currently considered the most common cause of nosocomial infections and one of the main causes of death in hospitalized patients. Due to its high morbidity and mortality rate and its ability to resist most antibiotics on the market, it has been termed a “superbug”. Its ability to form biofilms on biotic and abiotic surfaces seems to be the primarily means of MRSA antibiotic resistance and pervasiveness. Importantly, more tha…
The economic impact of rectal cancer: A population-based study in Italy list of authors
2021
Costs of cancer care are increasing worldwide, and sustainability of cancer burden is critical. In this study, the economic impact of rectal cancer on the Italian healthcare system, measured as public healthcare expenditure related to investigation and treatment of rectal cancer patients is estimated. A cross-sectional cohort of 9358 rectal cancer patients is linked, on an individual basis, to claims associated to rectal cancer diagnosis and treatments. Costs refer mainly to years 2010&ndash
New concept in bioderived composites: Biochar as toughening agent for improving performances and durability of agave-based epoxy biocomposites
2021
Biocomposites are increasingly used in the industry for the replacement of synthetic materials, thanks to their good mechanical properties, being lightweight, and having low cost. Unfortunately, in several potential fields of structural application their static strength and fatigue life are not high enough. For this reason, several chemical treatments on the fibers have been proposed in literature, although still without fully satisfactory results. To overcome this drawback, in this study we present a procedure based on the addition of a carbonaceous filler to a green epoxy matrix reinforced by Agave sisalana fibers. Among all carbon-based materials, biochar was selected for its environment…
Visual, Verbal and Everyday Memory 2 Years After Bariatric Surgery: Poorer Memory Performance at 1-Year Follow-Up
2021
Severe obesity has been associated with reduced performance on tests of verbal memory in bariatric surgery candidates. There is also some evidence that bariatric surgery leads to improved verbal memory, yet these findings need further elucidation. Little is known regarding postoperative memory changes in the visual domain and how patients subjectively experience their everyday memory after surgery. The aim of the current study was to repeat and extend prior findings on postoperative memory by investigating visual, verbal, and self-reported everyday memory following surgery, and to examine whether weight loss and somatic comorbidity predict memory performance. The study was a prospective, ob…
Genetics and Pathogenetic Role of Inflammasomes in Philadelphia Negative Chronic Myeloproliferative Neoplasms: A Narrative Review
2021
The last decade has been very important for the quantity of preclinical information obtained regarding chronic myeloproliferative neoplasms (MPNs) and the following will be dedicated to the translational implications of the new biological acquisitions. The overcoming of the mechanistic model of clonal evolution and the entry of chronic inflammation and dysimmunity into the new model are the elements on which to base a part of future therapeutic strategies. The innate immune system plays a major role in this context. Protagonists of the initiation and regulation of many pathological aspects, from cytokine storms to fibrosis, the NLRP3 and AIM2 inflammasomes guide and condition the natural hi…
Evaluation of Safety and Dosimetry of 177Lu-DOTA-ZOL for Therapy of Bone Metastases
2021
Palliative treatment of bone metastasis using radiolabeled bisphosphonates is a well-known concept proven to be safe and effective. A new therapeutic radiopharmaceutical for bone metastasis is 177Lu-DOTA-zoledronic acid (177Lu-DOTA-ZOL). In this study, the safety and dosimetry of a single therapeutic dose of 177Lu-DOTA-ZOL were evaluated on the basis of a series of SPECT/CT images and blood samples. Methods: Nine patients with exclusive bone metastases from metastatic castration-resistant prostate cancer (mCRPC) (70.8 ± 8.4 y) and progression under conventional therapies participated in this prospective study. After receiving 5,780 ± 329 MBq 177Lu-DOTA-ZOL, patients underwent 3-dimensional …
COVID-19: High-JAKing of the Inflammatory “Flight” by Ruxolitinib to Avoid the Cytokine Storm
2021
Since SARS-CoV-2 outbreak in December 2019, world health-system has been severely impacted with increased hospitalization, Intensive-Care-Unit (ICU) access and high mortality rates, mostly due to severe acute respiratory failure and multi-organ failure. Excessive and uncontrolled release of proinflammatory cytokines (cytokine release/storm syndrome, CRS) have been linked to the development of these events. The recent advancements of immunotherapy for the treatment of hematologic and solid tumors shed light on many of the molecular mechanisms underlying this phenomenon, thus rendering desirable a multidisciplinary approach to improve COVID-19 patients’ outcome. Indeed, currently available th…
Pheromonal imprinting in Drosophila melanogaster: preadult exposure affects free flight odor tracking in adult
2021
International audience
false
2021
We investigated the longitudinal links between parental teaching of reading and spelling and children’s word reading and spelling skills. Data of 244 Lithuanian parent–child dyads were analyzed, who were followed across three time points: end of kindergarten (T1;Mage= 6.88; 116 girls), beginning of Grade 1 (T2), and end of Grade 1 (T3). The children’s word reading and spelling skills were tested, and the parents answered questionnaires on the frequency with which they taught their children reading and spelling. Overall, the results showed that the parents were responsive to their children’s skill levels across the domains of reading and spelling and across time (i.e., the transition from ki…
Modeling and 'smart' prototyping human-in-the-loop interactions for AmI environments
2021
[EN] Autonomous capabilities are required in AmI environments in order to adapt systems to new environmental conditions and situations. However, keeping the human in the loop and in control of such systems is still necessary because of the diversity of systems, domains, environments, context situations, and social and legal constraints, which makes full autonomy a utopia within the short or medium term. Human-system integration introduces an important number of challenges and problems that have to be solved. On the one hand, humans should interact with systems even in those situations where their attentional, cognitive, and physical resources are limited in order to perform the interaction.…
La utilización de las preferencias musicales de los estudiantes desde un enfoque crítico. Hacia una educación musical democratizadora
2021
Una de las principales funciones que se asigna a las instituciones escolares es la de construir sujetos activos y críticos que contribuyan al desarrollo de las sociedades democráticas. Se trata de un objetivo transversal que debe tener su concreción en cada una de las áreas de conocimiento. Generalmente, este tipo de fin se persigue mediante la utilización de enfoques educativos críticos. En este sentido, aquí se estudian las posibilidades y dificultades didácticas que implican la incorporación de un enfoque de este tipo en la asignatura de música durante los últimos cursos de la etapa de educación primaria. Para ello, se ha implementado un proceso de investigación acción de dos ciclos en e…
Transverse Asymmetries of the Maxilla Even in Healthy and Apparently Symmetrical Subjects
2021
In the formulation of an orthodontic treatment plan, the three-dimensional analysis of the dental arches represents a fundamental moment for the evaluation of all the morphological parameters necessary in order to have a correct and complete diagnosis. In this regard, the study of the dental arches on the horizontal plane is sometimes neglected or not thorough enough. When evaluating the transverse dimensions of the dental upper arche, the presence of an asymmetry is frequently found, and it means that an hemiarch is larger than the other. Furthermore, any variation in one of the three planes of space always involves an alteration also on the other two planes in order to have compensation. …
Environmental Barriers and Facilitators to Physical Activity among University Students with Physical Disability—A Qualitative Study in Spain
2021
This paper qualitatively examines environmental factors operating as barriers and/or facilitators to participation in physical activity (PA) of people with physical disabilities. Interview data were collected from 27 Spanish university students through the innovative method of two-on-one interviews. Thereafter, data were subject to a flexible thematic analysis. Three themes were constructed: associations