showing 36 of ~574560 from 574555 documents
Looking ahead in games research
2021
This thematic issue presents a number of emerging scholarships into the study of digital gaming. The articles are based on a 2019 symposium on game studies hosted by the Digital Games Research section of ECREA. As the phenomena related to digital gaming keep on evolving and emerging, so must research keep up with the times and constantly challenge itself. Whether speaking about validating previously developed research methods, imagining totally new ones, or even challenging the whole philosophy of science on which research is being done, there is a constant need for reappraisal and introspection within games research. As a cultural medium that has become deeply embedded into the social fabr…
Performance Differences Using a Vibro-Tactile P300 BCI in LIS-Patients Diagnosed With Stroke and ALS
2021
Acceptorless dehydrogenative condensation: synthesis of indoles and quinolines from diols and anilines.
2021
The use of diols and anilines as reagents for the preparation of indoles represents a challenge in organic synthesis. By means of acceptorless dehydrogenative condensation, heterocycles, such as indoles, can be obtained. Herein we present an experimental and theoretical study for this purpose employing heterogeneous catalysts Pt/Al2O3 and ZnO in combination with an acid catalyst (p-TSA) and NMP as solvent. Under our optimized conditions, the diol excess has been reduced down to 2 equivalents. This represents a major advance, and allows the use of other diols. 2,3-Butanediol or 1,2-cyclohexanediol has been employed affording 2,3-dimethyl indoles and tetrahydrocarbazoles. In addition, 1,3-pro…
Effects of Vermicompost, Compost and Digestate as Commercial Alternative Peat-Based Substrates on Qualitative Parameters of Salvia officinalis
2021
Peat is a common substrate used for the cultivation of potted plants. However, the use of peat in horticulture has recently been questioned from an environmental standpoint, since it is a non-renewable resource and plays a major role in atmospheric CO2 sequestration. The aim of this work was to assess the potentialities of substrates obtained from vermicompost, compost and anaerobic digestion processes to partially substitute peat for sage (Salvia officinalis L.) cultivation. Therefore, we planned an experiment to assess the effect of these substrates on essential oil (EO) yield and composition, as well as on leaf nutrients concentration of sage plants. The three substrates were mixed with …
Iron intake among Lebanese women: sociodemographic factors, iron-rich dietary patterns, and preparation of hummus, a Mediterranean dish
2021
Background: Plant-based foods such as hummus are alternative to animal protein, and when properly pre-pared, they help to alleviate nutritional iron deficiency that leads to anemia, a global health problem. Objective: The objective was to assess iron intake among Lebanese women and related participant’s charac-teristics, discern iron-rich dietary patterns, evaluate their association with nutrients intake and participant’s sociodemographic characteristics, and identify the women preparing hummus traditionally and properly for an enhanced iron bioavailability. Design: A cross-sectional study of 400 Lebanese women (18–74 years old) was conducted in Lebanon. Data from a questionnaire, including…
Economic crisis and child maltreatment in Spain: the consequences of the recession in the child protection system
2021
Purpose This study aims to examine the consequences of the last great recession on the child protection system (CPS) in Spain, to estimate whether there is any kind of relationship between the conditions of socio-economic crisis and its protective activity. Design/methodology/approach Data on child protection legal measures issued by the CPS and socio-economic data from 8 of the 17 regions of the country were cross-checked. Using the chi-square test, it was possible to determine the significance and intensity of the relationship between the different variables in each of the regions of the study. Findings During the crisis, the number of recorded cases fell most sharply in those regions wi…
false
2021
Scholarly journals are often blamed for a gender gap in publication rates, but it is unclear whether peer review and editorial processes contribute to it. This article examines gender bias in peer review with data for 145 journals in various fields of research, including about 1.7 million authors and 740,000 referees. We reconstructed three possible sources of bias, i.e., the editorial selection of referees, referee recommendations, and editorial decisions, and examined all their possible relationships. Results showed that manuscripts written by women as solo authors or coauthored by women were treated even more favorably by referees and editors. Although there were some differences between…
Non-celiac wheat sensitivity: rationality and irrationality of a gluten-free diet in individuals affected with non-celiac disease: a review
2021
AbstractNon-celiac gluten or wheat sensitivity (NCWS) is a “clinical entity induced by the ingestion of wheat leading to intestinal and/or extraintestinal symptoms that improve once the wheat-containing foodstuff is removed from the diet, and celiac disease and wheat allergy have been excluded”. This mostly accepted definition raises several points that remain controversial on this condition. In the present review, the authors summarize the most recent advances in the clinic and research on NCWS through an accurate analysis of different studies. We screened PubMed, Medline, Embase, and Scopus using the keywords “non-celiac gluten sensitivity”, “non-celiac wheat sensitivity”, and “diagnosis”…
Genetic variation in the behavioural mechanisms involved in the response of the egg parasitoid Trissolcus brochymenae to contact chemical cues left b…
2021
International audience; 1. The ability of parasitoid females to perceive chemical traces left by theirhosts is of utmost importance in the host location process. The behaviours involved insuch ability have thus most likely been promoted by natural selection in the course ofthe evolutionary time. For this to happen, however, there must be signicant geneticvariation in natural populations on which natural selection could act.2. Using the isofemale line method and motion analysis, we detected signicantintra-population genetic variation for several walking behaviour traits of the eggparasitoid Trissolcus brochymenae (Hymenoptera: Scelionidae) females responding tochemical traces left by its h…
The Psychological Foundations of Management in Family Firms: Values, Biases, and Heuristics
2021
Considering the heterogeneity of family firm behaviors as reflecting the values, biases, and heuristics of individuals, we discuss the implications of the psychological foundations of management in family firms. We develop a conceptual framework for investigating how the values, biases, and heuristics of family and nonfamily members affect strategic decision-making and the outcomes of family firms. To advance the field, we put forward some relevant questions and offer a future research agenda at the intersection of the psychological foundations of management and family business.
<strong>Nomenclatural types of <em>Hieracium</em> (Asteraceae) species described from the Balearic Islands (Spain) and several rela…
2021
A nomenclatural revision of the genus Hieracium in the Balearic Islands (Spain) is presented and the typification of five names: H. aragonense Scheele, H. balearicum Arvet‑Touvet, H. elisaeanum Arvet-Touvet ex Willkomm, H. majoricanum Arvet-Touvet and H. microscapum Arvet-Touvet, is discussed. The names are lectotypified using specimens preserved at COI, GRM, and P herbaria. Several comments for the names H. cataractarum Arvet-Touvet & Huter and H. praecox subsp. brachypus Freyn in Porta & Rigo are also provided.
High-commitment work practices and the social responsibility issue: interaction and benefits
2021
Human Resource Management (HRM) has a potentially vital role to play in addressing the new challenges that companies have to face and in delivering initiatives in the framework of corporate sustainability. Our work attempts to shed light on the strategic role of High-Commitment Work Practices (HCWP) as a Corporate Sustainability (CS) partner and, more specifically, to analyze the implications of their integration on the competitiveness of the firm. With this purpose, we apply a qualitative methodology, using a single case study, to explore and explain why and how the interaction between HCWP and CS takes place. The results show how this interaction encourages the formulation and implementat…
Inference of SARS-CoV-2 spike-binding neutralizing antibody titers in sera from hospitalized COVID-19 patients by using commercial enzyme and chemilu…
2021
medRxiv: https://doi.org/10.1101/2020.09.07.20188151
Electrochemical Reduction and Oxidation of Ruddlesden–Popper-Type La2NiO3F2 within Fluoride-Ion Batteries
2021
Within this article, it is shown that an electrochemical defluorination and additional fluorination of Ruddlesden–Popper-type La2NiO3F2 is possible within all-solid-state fluoride-ion batteries. St...
The ATAL within the 2017 Asian Monsoon Anticyclone: Microphysical aerosol properties derived from aircraft-borne in situ measurements
2021
Abstract. The Asian summer monsoon is an effective pathway for aerosol particles and precursor substances from the planetary boundary layer over Central, South, and East Asia into the upper troposphere and lower stratosphere. An enhancement of aerosol particles within the Asian monsoon anticyclone (AMA) has been observed by satellites, called the Asian Tropopause Aerosol Layer (ATAL). In this paper we discuss airborne in situ and remote sensing observations of aerosol microphysical properties conducted during the 2017 StratoClim field campaign within the region of the Asian monsoon anticyclone. The aerosol particle measurements aboard the high-altitude research aircraft M55 Geophysica (reac…
Updated management of occipital nerve stimulator lead migration: case report of a technical challenge
2021
Abstract Electrode migration is a challenge, even with adequate anchoring techniques, due to the high mechanical stress on components of occipital nerve stimulation (ONS) for headache disorders. When a lead displacement of an ONS implant is diagnosed, there are currently different approaches described for its management. Nevertheless current neuromodulation devices are designed like a continuum of components without any intermediate connector, and if a lead displacement is diagnosed, the solution is the complete removal of the electrode from its placement, and its repositioning through an ex-novo procedure. The described technique can allow ONS leads to be revised while minimizing the need …
Psychiatric patients are more vulnerable to the Spanish euthanasia law?
2021
Ketamine in acute phase of severe traumatic brain injury “an old drug for new uses?”
2021
AbstractMaintaining an adequate level of sedation and analgesia plays a key role in the management of traumatic brain injury (TBI). To date, it is unclear which drug or combination of drugs is most effective in achieving these goals. Ketamine is an agent with attractive pharmacological and pharmacokinetics characteristics. Current evidence shows that ketamine does not increase and may instead decrease intracranial pressure, and its safety profile makes it a reliable tool in the prehospital environment. In this point of view, we discuss different aspects of the use of ketamine in the acute phase of TBI, with its potential benefits and pitfalls.
Materials for Respiratory Masks in the Context of COVID 19 Pandemic
2021
In the context of the COVID-19 pandemic and the lack of protective equipment worldwide, we aimed to study the literature for finding guidelines in the 3D manufacture of respiratory masks. We have searched for papers in CI-EXPANDED, SSCI, A&HCI, CPCI-S, CPCI-SSH, BKCI-S, BKCI-SSH, ESCI, CCR-EXPANDED, IC, using 3D printing materials sterilization and 3D printing materials disinfection keywords. From 80 results in databases, after refining, we selected six papers. We have also searched for manufacturers information regarding 3D printing materials sterilization or disinfection. We have found seven materials that are suitable for 3D printing and sterilization, with regards to multiple utili…
Social Media Data in an Augmented Reality System for Situation Awareness Support in Emergency Control Rooms
2021
AbstractDuring crisis situations, emergency operators require fast information access to achieve situation awareness and make the best possible decisions. Augmented reality could be used to visualize the wealth of user-generated content available on social media and enable context-adaptive functions for emergency operators. Although emergency operators agree that social media analytics will be important for their future work, it poses a challenge to filter and visualize large amounts of social media data. We conducted a goal-directed task analysis to identify the situation awareness requirements of emergency operators. By collecting tweets during two storms in Germany we evaluated the usefu…
7 Tesla MRI will soon be helpful to guide clinical practice in multiple sclerosis centres – No
2021
Hidden complexity in membrane permeabilization behavior of antimicrobial polycations.
2021
A promising alternative to classical antibiotics are antimicrobial peptides and their synthetic mimics (smAMPs) that supposedly act directly on membranes. For a more successful design of smAMPs, we need to know how the type of interaction with the membrane determines the type of membrane perturbation. How this, in turn, transfers into selectivity and microbial killing activity is largely unknown. Here, we characterize the action of two smAMPs: MM:CO (a copolymer of hydrophobic cyclooctyl subunits and charged β-monomethyl-α-aminomethyl subunits) and the highly charged poly-NM (a homopolymer of α-aminomethyl subunits). By thorough characterization of vesicle leakage experiments, we elucidate …
What are the effects of even-aged and uneven-aged forest management on boreal forest biodiversity in Fennoscandia and European Russia? A systematic r…
2021
Abstract Background Forest harvesting changes forest habitat and impacts forest dependent species. Uneven-aged management is often considered better for biodiversity than even-aged management, but there is an ongoing discourse over the benefits and disadvantages of different silvicultural systems. This systematic review contributes to the public discussion and provides evidence for policy making by synthesising current evidence on impacts of even-aged and uneven-aged forest management on biodiversity in boreal forests of Fennoscandia and European Russia. In this review even-aged and uneven-aged forest management are compared directly to each other as well as to natural forest to provide a b…
Effect of fluid resuscitation on cerebral integrity: A prospective randomised porcine study of haemorrhagic shock.
2021
BACKGROUND The treatment of haemorrhagic shock is a challenging task. Colloids have been regarded as standard treatment, but their safety and benefit have been the subject of controversial debates. Negative effects, including renal failure and increased mortality, have resulted in restrictions on their administration. The cerebral effects of different infusion regimens are largely unknown. OBJECTIVES The current study investigated the impact of gelatine-polysuccinate, hydroxyethyl starch (HES) and balanced electrolyte solution (BES) on cerebral integrity, focusing on cerebral inflammation, apoptosis and blood flow in pigs. DESIGN Randomised experimental study. SETTING University-affiliated …
Association of lifetime blood pressure with adulthood exercise blood pressure response : the cardiovascular risk in young Finns study
2021
Purpose: Elevated blood pressure (BP) in childhood has been associated with increased adulthood BP. However, BP and its change from childhood to adulthood and the risk of exaggerated adulthood exercise BP response are largely unknown. Therefore, we studied the association of childhood and adulthood BP with adulthood exercise BP response. Materials and methods: This investigation consisted of 406 individuals participating in the ongoing Cardiovascular Risk in Young Finns Study (baseline in 1980, at age of 6–18 years; follow-up in adulthood in 27–29 years since baseline). In childhood BP was classified as elevated according to the tables from the International Child Blood Pressure References …
Preparation of negative ion beams for the determination of the electron affinity of polonium by laser photodetachment
2021
A letter of intent submitted to the ISOLDE and Neutron-Time-of-flight Committee (INTC) at CERN to prepare the negative ion beam as a step towards measuring the electron affinity of polonium at CRIS (ISOLDE).
Natural selection mediated by seasonal time constraints increases the alignment between evolvability and developmental plasticity
2021
Abstract Phenotypic plasticity can either hinder or promote adaptation to novel environments. Recent studies that have quantified alignments between plasticity, genetic variation, and divergence propose that such alignments may reflect constraints that bias future evolutionary trajectories. Here, we emphasize that such alignments may themselves be a result of natural selection and do not necessarily indicate constraints on adaptation. We estimated developmental plasticity and broad sense genetic covariance matrices (G) among damselfly populations situated along a latitudinal gradient in Europe. Damselflies were reared at photoperiod treatments that simulated the seasonal time constraints ex…
Revealing Charge-Transfer Dynamics at Electrified Sulfur Cathodes Using Constrained Density Functional Theory
2021
To understand and control the behavior of electrochemical systems, including batteries and electrocatalysts, we seek molecular-level details of the charge transfer mechanisms at electrified interfaces. Recognizing some key limitations of standard equilibrium electronic structure methods to model materials and their interfaces, we propose applying charge constraints to effectively separate electronic and nuclear degrees of freedom, which are especially beneficial to the study of conversion electrodes, where electronic charge carriers are converted to much slower polarons within a material that is nonmetallic. We demonstrate the need for such an approach within the context of sulfur cathodes …
Towards multilingual competence: examining beliefs and agency in first year university students’ language learner biographies
2021
As working life across the world is increasingly multilingual, multicultural and multidisciplinary, higher education language teaching is faced with a challenge of how to prepare students for it. Many universities have recently developed multilingual pedagogies but central to their success is learners’ perceptions of these practices. To fill this gap, this article explores first year university students’ language learner biographies to gain insight into how learners construct their linguistic realities. The biographies were studied with discourse analytical methods to examine the participants’ beliefs about language learning and their sense of agency in it. The results reveal that participa…
Triage and Allocation of Neurocritical Care Resources During the COVID 19 Pandemic - A National Survey
2021
Objective: In light of the ongoing COVID-19 pandemic and the associated hospitalization of an overwhelming number of ventilator-dependent patients, medical and/or ethical patient triage paradigms have become essential. While guidelines on the allocation of scarce resources do exist, such work within the subdisciplines of intensive care (e.g., neurocritical care) remains limited.Methods: A 16-item questionnaire was developed that sought to explore/quantify the expert opinions of German neurointensivists with regard to triage decisions. The anonymous survey was conducted via a web-based platform and in total, 96 members of the Initiative of German Neurointensive Trial Engagement (IGNITE)-stud…
Antithrombotic Therapy in COVID-19: Systematic Summary of Ongoing or Completed Randomized Trials
2021
ABSTRACTEndothelial injury and microvascular/macrovascular thrombosis are common pathophysiologic features of coronavirus disease-2019 (COVID-19). However, the optimal thromboprophylactic regimens remain unknown across the spectrum of illness severity of COVID-19. A variety of antithrombotic agents, doses and durations of therapy are being assessed in ongoing randomized controlled trials (RCTs) that focus on outpatients, hospitalized patients in medical wards, and critically-ill patients with COVID-19. This manuscript provides a perspective of the ongoing or completed RCTs related to antithrombotic strategies used in COVID-19, the opportunities and challenges for the clinical trial enterpri…
Integrative bioinformatics and omics data source interoperability in the next-generation sequencing era-Editorial.
2021
With the advent of high-throughput and next-generation sequencing (NGS) technologies [1], huge amounts of ‘omics’ data (i.e. data from genomics, proteomics, pharmacogenomics, metagenomics, etc.) are continuously produced. Combining and integrating diverse omics data types is important in order to investigate the molecular machinery of complex diseases, with the hope for better disease prevention and treatment [2]. Experimental data repositories of omics data are publicly available, with the main aim of fostering the cooperation among research groups and laboratories all over the world. However, despite their openness, the effective integrated use of available public sources is hampered by t…
Development and validation of prediction model to estimate 10-year risk of all-cause mortality using modern statistical learning methods: a large pop…
2021
Abstract Background In increasingly ageing populations, there is an emergent need to develop a robust prediction model for estimating an individual absolute risk for all-cause mortality, so that relevant assessments and interventions can be targeted appropriately. The objective of the study was to derive, evaluate and validate (internally and externally) a risk prediction model allowing rapid estimations of an absolute risk of all-cause mortality in the following 10 years. Methods For the model development, data came from English Longitudinal Study of Ageing study, which comprised 9154 population-representative individuals aged 50–75 years, 1240 (13.5%) of whom died during the 10-year follo…
Conditioned Medium from Human Amnion-Derived Mesenchymal Stromal/Stem Cells Attenuating the Effects of Cold Ischemia-Reperfusion Injury in an In Vitr…
2021
The clinical results of lung transplantation (LTx) are still less favorable than other solid organ transplants in both the early and long term. The fragility of the lungs limits the procurement rate and can favor the occurrence of ischemia-reperfusion injury (IRI). Ex vivo lung perfusion (EVLP) with Steen SolutionTM (SS) aims to address problems, and the implementation of EVLP to alleviate the activation of IRI-mediated processes has been achieved using mesenchymal stromal/stem cell (MSC)-based treatments. In this study, we investigated the paracrine effects of human amnion-derived MSCs (hAMSCs) in an in vitro model of lung IRI that includes cold ischemia and normothermic EVLP. We found tha…
Fabrication of $^{15}\textrm{NV}^{-}$ centers in diamond using a deterministic single ion implanter
2021
Nitrogen Vacancy (NV) centers in diamond are a platform for several important quantum technologies, including sensing, communication and elementary quantum processors. In this letter we demonstrate the creation of NV centers by implantation using a deterministic single ion source. For this we sympathetically laser-cool single $^{15}\textrm{N}_2^+$ molecular ions in a Paul trap and extract them at an energy of 5.9\,keV. Subsequently the ions are focused with a lateral resolution of 121(35)\,nm and are implanted into a diamond substrate without any spatial filtering by apertures or masks. After high-temperature annealing, we detect the NV centers in a confocal microscope and determine a conve…
Application of the trans-contextual model to predict change in leisure time physical activity
2021
Objective: This study tested effects of changes in the psychological constructs of the trans-contextual model (TCM) on changes in adolescents' outside of school moderate-to-vigorous physical activity (PA) measured using self-report and accelerometer-based device. Design: A three-wave longitudinal design was used. High school students (N = 331) completed measures of all the TCM constructs at Time1 and at Time2, five weeks apart. Self-reported PA behaviour was measured also at Time3, five weeks after Time2. PA was measured using accelerometer-based devices for seven days following Time1 and Time3 for a census week. Results: A structural equation model using residual change scores revealed tha…