showing 36 of ~574560 from 574555 documents
Oxytocin signaling as a target to block social defeat-induced increases in drug abuse reward
2021
There is huge scientific interest in the neuropeptide oxytocin (OXT) due to its putative capacity to modulate a wide spectrum of physiological and cognitive processes including motivation, learning, emotion, and the stress response. The present review seeks to increase the understanding of the role of OXT in an individual’s vulnerability or resilience with regard to developing a substance use disorder. It places specific attention on the role of social stress as a risk factor of addiction, and explores the hypothesis that OXT constitutes a homeostatic response to stress that buffers against its negative impact. For this purpose, the review summarizes preclinical and clinical literature rega…
Les moulages, objets d’art et d’enseignement
2021
All-organic fast intersystem crossing assisted exciplexes exhibiting sub-microsecond thermally activated delayed fluorescence
2021
A novel strategy is presented towards acquisition of exciplex systems exhibiting thermally activated delayed fluorescence (TADF) with a high reverse intersystem crossing (RISC) rate (exceeding 107 s−1). This approach involves constructing exciplex donor–acceptor molecular pairs, where the acceptor molecule possesses the ability to undergo fast and efficient intersystem crossing (ISC). With the use of 6-cyano-9-phenylpurine (PCP) acceptor and carbazole-based donor molecules, exciplexes were obtained, where the excitation is contained on PCP and undergoes fast ISC to form a local excited triplet state (3LEA). The controlled excitation transfer to the 3LEA level provides an optimal reverse int…
Fremad-marsj! Retning kjem seinare. Ei analyse av iverksettinga av barnekonvensjonen og konvensjonen for personar med nedsett funksjonsevne under kom…
2021
Master´s thesis in Management (ORG917)
sj-docx-1-uix-10.1177_01617346211029656 – Supplemental material for Diagnostic Performance of Muscle Echo Intensity and Fractal Dimension for the Det…
2021
Supplemental material, sj-docx-1-uix-10.1177_01617346211029656 for Diagnostic Performance of Muscle Echo Intensity and Fractal Dimension for the Detection of Frailty Phenotype by Rebeca Mirón Mombiela, Jelena Vucetic, Paloma Monllor, Jenny S. Cárdenas-Herrán, Paloma Taltavull de La Paz and Consuelo Borrás in Ultrasonic Imaging
Supplementary Information from Oxidative stress and senescence in social insects—a significant but inconsistent link?
2021
Additional methods tables and figures
Selection of radiological methods in the diagnosis of pulmonary artery thromboembolism
2021
Bakalaura darbā ir veikta zinātniskās literatūras analīze par tēmu “Radioloģisko metožu izvēle plaušu artērijas trombembolijas diagnostikā”. Darba teorētiskajā daļā tika aprakstīts par krūšu kurvja anatomiju, krūšu kurvja asinsvadu anatomiju, par PATE patfizioloģiju, riska faktoriem, PATE klīniskajām izpausmēm un COVID-19 izraisītu PATE. Darba mērķis: zinātniskās literatūras analīze par radioloģisko metožu izvēli PATE diagnosticēšanā, metožu salīdzināšana. Pamatojoties uz literatūras datiem, COVID - 19 situāciju pasaulē, bakalaura darba tēma “Radioloģisko metožu izvēle plaušu artēriju trombembolijas diagnostikā” ir aktuāla. Pētījuma metadoloģija: literatūras avotu apkopošana, analīze un kva…
Lo sviluppo e l’innovazione
2021
Le norme della legge di bilancio per il 2021 in materia di sviluppo e innovazione sembrano ancora legate a una logica di natura emergenziale, ponendosi in continuitàconle normative adottate nel corso del 2020 per fare fronte alle fasi più acute della crisi causata dal Covid-19, con le quali, non a caso, condividono il carattere temporaneo degli interventi. Questi si basano su incentivi ai consumi, garanzie pubbliche sui prestiti bancari e varie provvidenze da distribuire tramite fondi pubblici appositamente istituiti. Sorprende l’assenza di progetti ambiziosi per lo sviluppo economico, che avrebbero potuto essere coordinati, o costituire anticipazioni, di quelli da inserire successivamente …
sj-docx-1-psp-10.1177_01461672211015896 – Supplemental material for Loudness Perceptions Influence Feelings of Interpersonal Closeness and Protect Ag…
2021
Supplemental material, sj-docx-1-psp-10.1177_01461672211015896 for Loudness Perceptions Influence Feelings of Interpersonal Closeness and Protect Against Detrimental Psychological Effects of Social Exclusion by Deming Wang, Ignazio Ziano, Martin S. Hagger and Nikos L. D. Chatzisarantis in Personality and Social Psychology Bulletin
Edukacja jutra. Współczesny stan etapów i dziedzin edukacji w Polsce
2021
Ustanowione przez poetę : szkice w stulecie urodzin Tadeusza Różewicza. T. 1
2021
Ar MYBPC1 saistītā miogēnā tremora dzīvnieku modeļsistēmas
2021
Nesenie atklājumi ģenētiski pārmantoto muskuļu slimību laukā parādīja, ka jauni varianti c.739T>C (p.Y247H) un c.742G>A (p.E248K) MYBPC1 gēnā, kas kodē lēno skeleta miozīnu saistošo proteīnu C, izraisa muskuļu miopātiju ar miogēnu tremoru. Bakalaura darba mērķis ir veikt MYBPC1 gēna patogēno variantu p.Y247H un p.E248K funkcionālo analīzi, izmantojot peļu knock-in modeļus. Darba izstrādē izmantotās metodes iekļauj transkriptomu bibliotēku sagatavošanu un analīzi, digitālo pilienu PCR un dzīvnieku modeļa funkcionālo izpēti. Darba gaitā tika analizēti divi peļu knock-in modeļi: vienam tika veikta gēnu ekspresijas analīze skeleta muskuļos, otram veikta sākotnējā funkcionālā analīze. Veiktie pē…
Carreras por montaña en la Comunitat Valenciana (1995-2019). Evolución, distribución territorial e incidencia en áreas naturales protegidas
2021
El rápido crecimiento de las carreras por montaña, ha motivado durante los últimos años su estudio. Aun son pocas las referencias bibliográficas que podemos encontrar a escala local, aunque algunas a nivel de España. Existen diferencias regionales, que demandan la necesidad de examinar este tipo de pruebas a una escala detallada. La Comunitat Valenciana, dada su extensión forestal y porcentaje de territorio montañoso (56 %), el número de espacios naturales (646) y superficie total protegida (40 %), se convierte en un buen ámbito de estudio. Una revisión bibliográfica y un análisis de la información recogida ha permitido determinar el número y la evolución de esta práctica en los últimos 25 …
Avantgarde Suomessa
2021
Avantgarde Suomessa on ensimmäinen suomalaista avantgardetaidetta laajasti käsittelevä teos. Se selvittää, miten avantgarden yhteiskunnalliset, poliittiset ja taiteelliset pyrkimykset näkyvät suomalaisessa kirjallisuudessa, kuvataiteessa, arkkitehtuurissa, muodissa ja musiikissa. Suomalaiset taiteilijat ovat olleet osa avantgarden kansainvälisiä verkostoja 1900-luvun alusta asti. Kirjan läpäisevänä teemana on taiteen kansainvälisyyden ja kansallisuuden ristiveto. Teos auttaa ymmärtämään nykytaiteen yhteyden varhaiseen avantgardeen ja osoittaa suomalaisten naistoimijoiden, kuten Ellen Thesleffin, Hagar Olssonin ja Armi Ratian, merkityksen avantgardelle. Samalla artikkelikokoelma luo kriittis…
Lost in Draft: Investigating Game Balance in Multiplayer Online Battle Arena Drafting
2021
Master´s thesis in Information and Communication Technology (IKT590) University of Agder, Grimstad This thesis explores modern machine learning solutions to turn-basedstrategy games. In particular, we explore the possibilities of equalizing the playing field for both teams in the draft phase of Defense of the Ancients 2 (Dota 2) and League of Legends (LoL), with both games being giants in the multi-million dollar esports industry. The thesis covers the Multiplayer Online Battle Arena video game genre and the draft phase the games use. We also discuss the tech-nology used to address the problem, as well as the basic concepts of modern machine learning that allowed this technology to arise. W…
Kinestētisko mācību metožu attīstīšana zviedru valodas apguvē 10.-12.klasei
2021
Darba tēma: Kinestētisko mācību metožu attīstīšana zviedru valodas apguvē 10.-12.klasei Darba autore: Mārīte Tīsa Darba vadītāja: Guna Svence, Dr. psych. prof. Darba veids: diplomdarbs Darba apjoms: 46 lappuses, 62 bibliogrāfiskie nosaukumi, 4 attēli, 2 tabulas, 7 pielikumi Darba mērķis ir apzināt skolēnu un skolotāju pieredzi svešvalodu apguvē, analizējot mācību metožu dažādību un akcentējot kinestētisko metožu izmantošanu. Tiek analizēti pētījumi par mācīšanās stilu nozīmi, nodrošinot efektīvu mācību procesu, un nepieciešamību piemērot mācību metodes visiem skolēniem, paaugstinot skolēnu motivāciju, sekmes un pašvērtējumu. Skolotājiem jāattīsta prasme atpazīt savu mācīšanās un mācīšanas s…
Metsäluonnon turvaava suojelun kohdentaminen Suomessa
2021
Tässä mietinnössä Luontopaneeli keskittyy Suomen pinta-alaltaan suurimman ja siten lajien kannalta merkityksellisimmän elinympäristön eli boreaalisten metsien suojelun kohdentamiseen. EU:n BD-strategiassa mainitut käsitteet vanha metsä ja luonnontilainen metsä eivät ole yksiselitteisiä, ja niiden määritelmiin voidaan perustellusti esittää erilaisia näkökohtia. Tämän ei tule estää rationaalisten suojelusuunnitelmien tekoa. Luontopaneeli korostaa, että käsitteiden määrittelyn sijaan tärkeintä on EU:n BD-strategian tavoitteiden eli luonnon monimuotoisuuden säilymisen ja kokonaisheikentymättömyyden saavuttaminen. Tässä mietinnössä Luontopaneeli esittää laskelman, jolla Suomi voi metsien osalta …
Considering lithium-ion battery 3D-printing via thermoplastic material extrusion and polymer powder bed fusion
2021
Abstract In this paper, the ability to 3D print lithium-ion batteries through Pmnbspace thermoplastic material extrusion and polymer powder bed fusion is considered. Focused on the formulation of positive electrodes composed of polypropylene, LiFePO4 as active material, and conductive additives, advantages and drawbacks of both additive manufacturing technologies, are thoroughly discussed from the electrochemical, electrical, morphological and mechanical perspectives. Based on these preliminary results, strategies to further optimize the electrochemical performances are proposed. Through a comprehensive modeling study, the enhanced electrochemical suitability at high current densities of va…
Standardized general purpose technologies: A note
2021
General purpose technologies (GPTs) have been important drivers of industrial revolutions and economic development, but their link to standards has not been analyzed systematically. We document that all of the most common examples of GPTs—steam, railway, electricity and information (and communication) technology—have been subject to standardization efforts over time. Standards development has acted as an institution that has more or less made an impact on the technological progress in these fields and their application sectors. While empirical studies of GPTs have utilized, among other things, patent data to identify GPTs, our observations indicate that the analysis of standards organizatio…
Conflicto entre los cabildos catedralicios y las inquisiciones ibéricas en la Edad Moderna
2021
Ristiretkeltä jumalattoman esivallan alle : papillinen diskurssi Suomessa 1941-1948
2021
Does Work Have to Make Sense? Work Engagement in a Group of Micro-Entrepreneurs. The Mediating Role of Coherence at Work
2021
Keski-Suomen sosiaali- ja terveysmenojen tulevaisuudennäkymät
2021
Paplašinātā realitāte mobilajās aplikācijās - tās nozīme mārketingā un ietekme uz patērētāju.
2021
Bakalaura tēma ir “Papildinātā realitāte mobilajās aplikācijās, tās nozīme mārketingā un ietekme uz patērētāju”. Darba mērķis ir, pamatojoties uz teorijas atziņām par mobilo lietotņu un papildinātās realitātes izmantošanas iespējām mārketingā un patērētāju aptaujas rezultātiem, izpētīt papildinātās realitātes ietekmi uz patērētājiem Latvijā, noskaidrot nozīmi mārketingā un sniegt priekšlikumus tās iekļaušanai Latvijas uzņēmumu mārketinga darbībā. Pētāmā problēma ir papildinātās realitātes mobilo aplikāciju ietekmes uz patērētājiem un nozīmes mārketingā pētīšanas nepieciešamība Latvijas tirgū. Darbs sastāv no 3 nodaļām. Pirmajā nodaļā tiek aplūkoti mobilo aplikāciju teorētiskie aspekti, lai …
Multigenerational study of the obesogen effects of bisphenol S after a perinatal exposure in C57BL6/J mice fed a high fat diet.
2021
International audience; Background : Bisphenol S is an endocrine disruptor exhibiting metabolic disturbances, especially following perinatal exposures. To date, no data are available on the obesogen effects of BPS in a mutligenerational issue.Objectives : We investigated obesogen effects of BPS in a multigenerational study by focusing on body weight, adipose tissue and plasma parameters in male and female mice.Methods : Pregnant C57BL6/J mice were exposed to BPS (1.5 μg/kg bw/day ie a human equivalent dose of 0.12 μg/kg bw/day) by drinking water from gestational day 0 to post natal day 21. All offsprings were fed with a high fat diet during 15 weeks. Body weight was monitored weekly and fat…
Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial
2021
Introduction: Large randomized trials testing the effect of a multifactorial weight-loss lifestyle intervention including Mediterranean diet (MedDiet) on renal function are lacking. Here, we evaluated the 1-year efficacy of an intensive weight-loss intervention with an energy-reduced MedDiet (erMedDiet) plus increased physical activity (PA) on renal function. Methods: Randomized controlled "PREvención con DIeta MEDiterránea-Plus"(PREDIMED-Plus) trial is conducted in 23 Spanish centers comprising 208 primary care clinics. Overweight/obese (n = 6,719) adults aged 55-75 years with metabolic syndrome were randomly assigned (1:1) to an intensive weight-loss lifestyle intervention with an erMedDi…
Nefrologia – postępy 2020/2021
2021
Forme di narrazione e comunicazione partecipative. A partire da Estetica relazionale di Nicolas Bourriaud
2021
Il contributo utilizza il modello teorico dell'Estetica relazionale di Nicolas Bourriaud per comprendere le dinamiche della comunicazione che la contemporaneità sta sperimentando sui social network. The contribution uses the theoretical model of Nicolas Bourriaud's Relational Aesthetics to understand the dynamics of communication that are used and experienced on social networks.
Nonlocal analytical solution for multilayered composite shells
2021
Abstract In this work, an advanced nonlocal analytical formulation for the static analysis of composite shell structures is proposed. The governing equations are derived from the Principle of Virtual Displacement (PVD) [1] and are solved by the use of the Navier solution [2]. Layer-Wise models related to linear up to fourth order variations of the unknown variables in the thickness direction are treated. The modelization of multilayered structure materials takes into account the composite material properties and the nonlocal behavior based on the work of Eringen [3]. In order to take into account the nonlocality of the material, the Eringen’s stress-gradient model is employed [4]. The novel…
Hereditary Cancers and Genetics
2021
The study of hereditary syndromes is fundamentally based on the finding and identification of susceptibility genes underlying the pathology. Although hereditary tumors account for only a small fraction of all the tumors, the knowledge of underlying genetics changed the clinical management of affected patients and their families, also providing important information on the molecular mechanisms involved in the development of sporadic tumors. In the subjects who inherit a germline mutation, all the cells of the organism are carriers of that mutation, predisposing such subject to develop neoplasm more easily and earlier compared to the general population. The identification of individuals with …
Auto vadīšanai rekomendēto briļļu lēcu ietekme uz redzi
2021
Darbs ir uzrakstīts latviešu valodā uz 38 lappusēm. Tas satur 20 attēlus, 8 tabulas, 32 atsauces uz literatūras avotiem un 1 pielikumu. Darba mērķis: izvērtēt vai auto vadīšanai paredzētās briļļu lēcas ietekmē redzi. Redzes asuma mērījumi tika veikti 13 dalībniekiem ar ‘FrACT’ programmu- bez pieliktas lēcas, ar lēcu bez klājuma, ar lēcu ar pretatspīduma klājumu, ar lēcu, kas rekomendēta auto vadīšanai. Rezultātā noskaidrojām, ka briļļu lēca, kas rekomendēta auto vadīšanai un briļļu lēca ar pretatspīduma klājumu būtiski uzlaboja redzes asumu. Atslēgvārdi: redzes asums, auto vadīšana, briļļu lēcu pārklājumi, nakts redzes traucējumi.
From evidence to practice: Implementation of the Housing First program in Poland
2021
Histone post-translational modifications as potential therapeutic targets for pain management
2021
Effective pharmacological management of pain associated with tissue pathology is an unmet medical need. Transcriptional modifications in nociceptive pathways are pivotal for the development and the maintenance of pain associated with tissue damage. Accumulating evidence has shown the importance of the epigenetic control of transcription in nociceptive pathways via histone post-translational modifications (PTMs). Hence, histone PTMs could be targets for novel effective analgesics. Here, we discuss the current understanding of histone PTMs in the modulation of gene expression affecting nociception and pain phenotypes following tissue injury. We also provide a critical view of the translationa…
Standardisation and social ordering: A change of perspective
2021
This article examines standardisation in synthetic biology as a form of social coordination and ordering. I discuss standardisation by exploring what makes standards possible, and offer an understanding based on infrastructures: technical and social systems that support the existence and operation of accepted standards. By exploring the role of social infrastructures, I contend that standards depend upon social ordering: ways of arranging people in particular positions, relations, and hierarchies. I suggest that synthetic biologists ought to develop an awareness of these social orders, take responsibility for their creation, and accept accountability for their consequences, both technical a…
TiO2 in memristors and resistive random access memory devices
2021
Abstract One of the most recent applications of TiO2 thin films is as an oxide layer in memristors, electronic devices considered as one of the most promising nonvolatile memories and as possible building units for neuromorphic computing. This chapter aims to describe several fabrication ways, either (electro)chemical or physical methods, of TiO2 thin films and to highlight the relationship between method and layer properties. Some fundamentals on the mechanism of memristors’ operation, that is, resistive switching in oxide thin films, will be given, classifying the different types of devices based on the used electrode materials and underlying physicochemical processes. Finally, it will be…