Desired cybersecurity skills and skills acquisition methods in the organizations

2022

Abstract:Key personnel and their competences play important roles in continuity management and improving resilience of cybersecurity in organizations. Researchers have addressed many topics and studies in the cybersecurity domain. However, relevant cybersecurity skills and acquisition of them in expertise development, have only been partially touched. If designed systematically and properly, cybersecurity training can improve cybersecurity expertise to ensure better performance in complex cybersecurity situations. More through study on the acquisition of cybersecurity skills, and work-life needs are needed. The research three questions of this study are: How do work-life representatives see…

Reliability of extracellular contrast versus gadoxetic acid in assessing small liver lesions using liver imaging reporting and data system v.2018 and…

2022

Background & aims: The diagnostic accuracy of Liver Imaging Reporting and Data System (LI-RADS) v.2018 and European Association for the Study of the Liver (EASL) criteria for the diagnosis of HCC have been widely evaluated, but their reliability should be investigated. We aimed to assess and compare the reliability of LI-RADS v.2018 and EASL criteria for the diagnosis of HCC using MRI with extracellular contrast agents (ECAs) and gadoxetic acid (GA) and determine the effect of ancillary features on LI-RADS reliability. Approach & results: Ten readers reviewed MRI studies of 92 focal liver lesions measuring <3 cm acquired with ECAs and GA <1 month apart from two prospective tri…

An Enhanced Multifactor Multiobjective Approach for Software Modularization

2022

Complex software systems, meant to facilitate organizations, undergo frequent upgrades that can erode the system architectures. Such erosion makes understandability and maintenance a challenging task. To this end, software modularization provides an architectural-level view that helps to understand system architecture from its source code. For modularization, nondeterministic search-based optimization uses single-factor single-objective, multifactor single-objective, and single-factor multiobjective, which have been shown to outperform deterministic approaches. The proposed MFMO approach, which uses both a heuristic (Hill Climbing and Genetic) and a meta-heuristic (nondominated sorting gene…

Organisational Drivers and Challenges in Circular Economy Implementation : An Issue Life Cycle Approach

2022

Business is a significant cause of various global sustainability challenges addressed by the Circular Economy (CE), making companies instrumental in the transition from a linear economic model to a circular one. While drivers and challenges in corporate CE implementation have been researched on an organisational level, a more detailed understanding is needed regarding their contextual nature and interplay with the evolution of CE implementation in a company. Utilising issue life cycle theory, this study contributes to the literature on CE implementation in business by displaying differences in corporate CE implementation drivers and challenges, relating to the time since starting, and the …

Forståelsen av lærerutdannerrollen blant skolebaserte lærerutdannere i Norge

2022

I denne artikkelen undersøker vi praksislæreres forståelse av sin rolle som lærerutdannere. Denne kvalitative studien er basert på analysen av 104 refleksjonsnotater fra praksislærere ved fem lærerutdanningsskoler i Norge. Deltagerne ble bedt om å reflektere over sin rolle som lærerutdannere. Under analyseprosessen kom vi fram til at deltagerne i studien forstår sin lærerutdannerrolle som (1) portvoktere for- og ivaretagere av lærerprofesjonen, (2) veiledere og (3) relasjonsbyggere og rollemodeller. Vi diskuterer studiens resultater i lys av teori og tidligere forskning samt reflekterer rundt de etiske overveielsene som kan ha påvirket studiens resultater. Studien kaster et kritisk blikk på…

Ketogenic and Modified Mediterranean Diet as a Tool to Counteract Neuroinflammation in Multiple Sclerosis: Nutritional Suggestions.

2022

Ketogenic Diet is a nutritional pattern often used as dietotherapy in inflammatory diseases, including neurological disorders. Applied on epileptic children since 1920, in recent years it has been taken into account again as a tool to both reduce inflammatory burdens and ameliorate the nutritional status of patients affected by different pathologies. Multiple sclerosis (MS) is considered an immune-mediated neuro-inflammatory disease and diet is a possible factor in its pathogenesis. The aim of this work is to investigate the main potential targets of MS-related impairments, in particular the cognitive deficits, focusing on the alteration of biomarkers such as the Brain Derived-Neurotrophic …

Meme marketing: How marketers can drive better engagement using viral memes?

2022

Scholars and industry stakeholders have exhibited an interest in identifying the underlying dimensions of viral memes. However, the recipe for creating a viral meme remains obscure. This study makes a phenomenological contribution by examining viral memes, exploring the antecedents (i.e., content-related factors, customer-related factors, and media-related factors), consequences, and moderating factors using a mixed-method approach. The study presents a holistic framework for creating viral memes based on the perceptions of customers and industry stakeholders. Four quantitative studies (i.e., a lab experiment, an online quasi-experiment, an event study, and a brand recall study) validate th…

New Developments in the Production and Research of Actinide Elements

2022

Atoms 10(2), 61 (2022). doi:10.3390/atoms10020061

Pandemetrics: systematically assessing, monitoring, and controlling the evolution of a pandemic

2022

AbstractThe still ongoing pandemic of SARS-CoV-2 virus and COVID-19 disease, affecting the population worldwide, has demonstrated the need of more accurate methodologies for assessing, monitoring, and controlling an outbreak of such devastating proportions. Authoritative attempts have been made in traditional fields of medicine (epidemiology, virology, infectiology) to address these shortcomings, mainly by relying on mathematical and statistical modeling. However, here, we propose approaching the methodological work from a different, and to some extent alternative, standpoint. Applied systematically, the concepts and tools of statistical engineering and quality management, developed not onl…

Translational readthrough inducing drugs: a study of toxicity in mice models and in vitro safety validation of the specific readthrough process.

2022

Objective Nonsense mutations are responsible for 15% of Cystic Fibrosis (CF) patients due to the introduction of a premature stop codon (PTC) in the mRNA and the production of a truncated CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) protein1. A promising therapeutic approach for stop mutations is the suppression therapy by Translational Readthrough Inducing Drugs (TRIDs) to restore the expression of the protein2,3. Recently three new TRIDS (NV848, NV914, NV930) have been proposed and validated by several assays. Our work was focused on TRIDs NV848, NV914, NV930. Important aspects of TRIDs to be evaluated are their specificity towards PTC, to demonstrate that TRIDs do not inter…

crystal structure of mouse cryptochrome1 in complex with period2

2022

IN-UTERO Δ9-TETRAHYDROCANNABINOL EXPOSURE IMPINGES ON BRAIN EXECUTIVE PROCESSES TOWARDS EMOTIONAL, COGNITIVE IMPAIRMENT, AND ALCOHOL VULNERABILITY IN…

2022

Periphyton as a key diet source of essential fatty acids for macroinvertebrates across a nutrient and dissolved organic carbon gradient in boreal lak…

2022

We studied how physiologically important long-chain polyunsaturated fatty acids (PUFA) in benthic macroinvertebrates (Asellus aquaticus, Chironomidae, and Oligochaeta) were related to those in periphyton and terrestrial organic matter (tree leaves), collected from littoral areas of 17 boreal lakes that differed in their dissolved organic carbon (DOC) and nutrient (phosphorus and nitrogen) concentrations. We also analyzed fatty acid (FA)-specific stable carbon isotopes (δ13CFA) to investigate the dietary origin (periphyton vs. terrestrial organic matter) of PUFA in the consumers. In contrast to periphyton, terrestrial organic matter was deprived of long-chain PUFA, such as eicosapentaenoic a…

How Fragile We Are: Influence of Stimulator of Interferon Genes (STING) Variants on Pathogen Recognition and Immune Response Efficiency.

2022

AbstractThe STimulator of INterferon Genes (STING) protein is a cornerstone of the human immune response. Its activation by cGAMP upon the presence of cytosolic DNA stimulates the production of type I interferons and inflammatory cytokines which are crucial for protecting cells from infections. STING signaling pathway can also influence both tumor-suppressive and tumor-promoting mechanisms, rendering it an appealing target for drug design. In the human population, several STING variants exist and exhibit dramatic differences in their activity, impacting the efficiency of the host defense against infections. Understanding the differential molecular mechanisms exhibited by these variants is o…

Experiments and Facilities for Accelerator-Based Dark Sector Searches

2022

This paper provides an overview of experiments and facilities for accelerator-based dark matter searches as part of the US Community Study on the Future of Particle Physics (Snowmass 2021). Companion white papers to this paper present the physics drivers: thermal dark matter, visible dark portals, and new flavors and rich dark sectors.

Get up, stand up: Alongside adolescents and young adults with cancer for their right to be forgotten

2022

Adolescent and young adult cancer survivors may experience various forms of social difficulties years or even decades after completing their cancer treatments. This article will hopefully help the Italian national project dedicated to adolescents and young adults with cancer promoting political and legal solutions to stop discrimination and supporting the right to be forgotten.

Ruling out some predictions of deeply-bound light-heavy tetraquarks using lattice QCD

2022

We discuss our lattice QCD calculations of a number of tetraquark channels with at least one heavy quark where some phenomenological models, already fully constrained by fits to the ordinary meson and baryon spectrum, predict deep binding. We find no evidence of deeply-bound tetraquarks, except in previously established strong-interaction stable $I=0$, $J^P=1^+$, $ud\bar{b}\bar{b}$ and $I=1/2$, $J^P=1^+$ $\ell s\bar{b}\bar{b}$ (where $\ell=u/d$) channels, allowing us to rule out models predicting deep binding. Preliminary results from an updated analysis of doubly-bottom tetraquarks are also presented.

Asymptotics for third-order nonlinear differential equations: Non-oscillatory and oscillatory cases

2022

We discuss a third-order differential equation, involving a general form of nonlinearity. We obtain results describing how suitable coefficient functions determine the asymptotic and (non-)oscillatory behavior of solutions. We use comparison technique with first-order differential equations together with the Kusano–Naito’s and Philos’ approaches.

An overview of orthodontic malpractice liability based on a survey and case assessment review.

2022

The purpose of this survey study and case review was to identify 1) the common causes related to filing a malpractice claim against an orthodontist and, 2) the factors mitigating against a potential malpractice claim in the United States (U.S). The objectives of the case review were to examine the current state of orthodontic malpractice litigation from a cause and mitigating point of view.Data for this research was collected and reviewed using the following two methods: 1) A survey questionnaire on aspects of malpractice liability was electronically distributed to 2,241 active U.S. members of the American Association of Orthodontists (AAO). 2) Legal cases were reviewed on the online legal …

Sguardo di ascolto: note di ricerca sul film Aylesbury Estate (2020)

2022

Aylesbury Estate (2020) è un lungometraggio documentario sul noto complesso abitativo di social housing londinese, nel quale ho abitato per alcuni anni. Il film, da me diretto tra il 2017 e il 2020, segue il percorso esistenziale ed emotivo di alcuni residenti dell’Aylesbury mentre si fa strada il lungo processo di demolizione dello stesso. Nel ripercorrere il processo di realizzazione del film e attraverso l’analisi di alcune sequenze del film finito, questo articolo propone uno ‘sguardo di ascolto’ per condurre ricerca sul campo attraverso il mezzo filmico.

Impact of Separator Thickness on Temperature Distribution in Single Cell of Polymer Electrolyte Fuel Cell Operated at Higher Temperature of 90 °C and…

2022

The New Energy and Industry Technology Development Organization (NEDO) road map (Japan, 2017) has proposed that a polymer electrolyte fuel cell (PEFC) system, which operates at a temperature of 90 °C and 100 °C, be applied for stationary and mobility usage, respectively. This study suggests using a thin polymer electrolyte membrane (PEM) and a thin gas diffusion layer (GDL), at the same time, to achieve better power-generation performance, at a higher temperature than usual. The focus of this paper is to clarify the effect of separator thickness on the distribution of temperature at the reaction surface (Treact), with the relative humidity (RH) of the supply gasses and initial operation tem…

Risk Burden of Coronary Perforation in Chronic Total Occlusion Recanalization: Latin American CTO Registry Analysis

2022

Background Coronary perforation is a life‐threatening complication of acute percutaneous coronary intervention (PCI) for chronic total occlusions (CTO), but data on midterm outcomes are limited. Methods and Results Data from LATAM (Latin American)‐CTO Registry (57 centers; 9 countries) were analyzed. We assessed the risk of 30‐day, 1‐year major adverse cardiac events of coronary perforation using time‐to‐event and weighted composite end point analysis having CTO PCI without perforation as comparators. Additionally, we studied the independent predictors of perforation in these patients. Of 2054 patients who underwent CTO PCI between 2015 and 2018, the median Multicenter CTO Registry in Japa…

Trust-oriented affordances: A five-country study of news trustworthiness and its socio-technical articulations

2022

Research on trust has come to the forefront of communication studies. Beyond the dominant focus on informational trust and its country-specific articulations, trustworthiness evaluations can relate to the materiality of news and its global manifestations. Especially in digital algorithmic environments, understanding news trustworthiness requires a holistic approach, which combines informational and socio-technical aspects while addressing both institutional and interpersonal trust. Drawing on 488 in-depth interviews with media consumers in Argentina, Finland, Israel, Japan, and the United States, this article investigates news (dis)trust from the lens of socio-materiality. The six trust-or…

Modelling Nannochloropsis gaditana Growth in Reactors with Different Geometries, Determination of Kinetic Parameters and Biochemical Analysis in Resp…

2022

Microalgae are unicellular and photosynthetic microorganisms which grow thanks to inorganic salts, CO2 and light, and find applications in several fields thanks to their variety. The industrial application of microalgae has not often been fully exploited because of a lack of information about how microalgae respond to inputs and to different growth environments. In the present work a model able to predict the microalgae growth in reactors with different geometries was developed. We combined a Monod-like model for the specific growth rate with the Lambert-Beer law of homogeneous light distribution in thick photobioreactors. Kinetic parameters related to the cultivation of the microalga Nanno…

ESSAI DE RÉFLEXION SUR LA PLACE DE L'ÉTHIQUE DANS LES ARTICLES DE LA CDI SUR LA RESPONSABILITÉ DE L'ÉTAT

2022

International audience; De l'éthique dans les Articles de la CDI sur la responsabilité des États pour fait internationalement illicite ? La question peut surprendre. Pourtant, l'éthique, entendue comme un processus de questionnement relatif à ce qui est considéré, à un moment et dans une société donnée, comme juste et bon, a à tout le moins constitué une source d'inspiration-c'est-à-dire une source matérielle-de certains articles voire de certains chapitres du projet. Plus encore, l'éthique peut être considérée comme la matrice d'une notion fondamentale du droit international contemporain, que l'on retrouve dans les Articles de 2001 : le jus cogens. Cette présence de l'éthique dans la const…

3D models acquisition and image processing for virtual musealization of the spezieria di Santa Maria della Scala, Rome

2022

This study was carried out within the project “Roma Hispana. Nuevas tecnologías aplicadas al estudio histórico, la musealización y la puesta en valor de Patrimonio Cultural español en Roma: la spezieria di Santa Maria della Scala” (Universitat de València Spain), which is funded by the Conselleria d’Innovació, Universitats, Ciència i Societat Digital of the Generalitat Valenciana (2020–2021) and authorized by the Sovrintendenza Speciale Archeologia Belle Arti e Paesaggio (Special Superintendence of Archeology, Fine Arts and Landscape) of Rome, Italy. The spezieria di Santa Maria della Scala was the oldest apothecary in…

Statistical survey focused on diffusion and knowledge of energy drinks, conducted in Palermo

2022

In recent years energy drinks consumption has increased, due to their ability to improve physical and cognitive performance. Unfortunately, because of poor or incorrect information, people are not always aware of the harmful consequences of these drinks such as obesity, diabetes, hypertension, tachycardia until death. Therefore, we conducted a statistical survey in the Palermo area, submitting a paper questionnaire to 1003 people. Data analysis shows that only 29% of the audience never consumed energy drinks, while 71% tried them at least once in their life, especially in adolescence; 81% never or rarely drink them, 14% drink them a few times a month, while 5% drink them several times a wee…

Base-promoted direct amidation of esters: beyond the current scope and practical applications

2022

The base-promoted direct amidation of unactivated esters is among the most useful reactions for amide bond formation in contemporary organic chemistry. The intensive research in this area has led to the development of a number of new methods to achive this transformation. However, to date, the existing literature is more methodological and in many instances lacks practical directions. Therefore, the full potential of this transformation is yet to be revealed by broadening the substrate scope. In a search for new practical applications of the amidation reaction, herein we present a comprehensive study of a number of base-promoted direct amidations that encompass a wide range of amines and es…

New Perspectives and Challenges in Traffic and Transportation Engineering Supporting Energy Saving in Smart Cities—A Multidisciplinary Approach to a …

2022

Transportation, like other spheres of human activity, is constantly changing due to economic development. People are constantly improving the ways of moving using various energy sources, expanding infrastructures, and adapting cities to increasing traffic volumes. An efficient, modern, and demand-driven transportation infrastructure is the strength of a growing economy. The development of transportation improves the accessibility of regions and labor markets and reduces the nuisance caused by congestion. All these elements translate into economic benefits, competitiveness, increased productivity of enterprises and regions, as well as social benefits. However, transport consumes enormous ene…

Do patients' and referral centers' characteristics influence multiple sclerosis phenotypes? Results from the Italian multiple sclerosis and related d…

2022

Abstract Background Multiple sclerosis (MS) is characterized by phenotypical heterogeneity, partly resulting from demographic and environmental risk factors. Socio-economic factors and the characteristics of local MS facilities might also play a part. Methods This study included patients with a confirmed MS diagnosis enrolled in the Italian MS and Related Disorders Register in 2000–2021. Patients at first visit were classified as having a clinically isolated syndrome (CIS), relapsing–remitting (RR), primary progressive (PP), progressive-relapsing (PR), or secondary progressive MS (SP). Demographic and clinical characteristics were analyzed, with centers’ characteristics, geographic macro-ar…

DNASE1L3 deficiency, new phenotypes, and evidence for a transient type I IFN signaling.

2022

Background: Deoxyribonuclease 1 like 3 (DNASE1L3) is a secreted enzyme that has been shown to digest the extracellular chromatin derived from apoptotic bodies, and DNASE1L3 pathogenic variants have been associated with a lupus phenotype. It is unclear whether interferon signaling is sustained in DNASE1L3 deficiency in humans. Objectives: To explore interferon signaling in DNASE1L3 deficient patients. To depict the characteristic features of DNASE1L3 deficiencies in human. Methods: We identified, characterized, and analyzed five new patients carrying biallelic DNASE1L3 variations. Whole or targeted exome and/or Sanger sequencing was performed to detect pathogenic variations in five juvenile …

Vernacular budgeting and accounting routines – a longitudinal constructive case study

2022

PurposeThis case study aims to report a longitudinal analysis of the development and use of local “vernacular” accounting practice and a digital rolling-forecast system known as TeamBudget in a public sector organization.Design/methodology/approachThe study employs the constructive research approach which utilizes participative observation in the development of TeamBudget over the 15 years since 2004. The empirical data utilized includes eight interviews and documentary data for the system created.FindingsThe study demonstrates how the actions of employees responsible for developing a locally relevant financial planning system, TeamBudget, facilitated the emergence of new accounting routine…

Information Disclosure and Sustainable Competitive Advantage: Evidence from the Spanish Tourism Industry

2022

Of all the resources and capabilities that have a well-established impact on decision-making, information stands out. With the advent of the digital economy, organizations have been making significant information and communication technology (ICT) investments, but the empirical evidence of the impact of these investments on business outcomes has been inconsistent. This article studies the conditions that disclosed information resources and ICT must fulfil in order to become a source of sustainable competitive advantage in tourism organizations. The results point to the need to identify distinct financial and non-financial information dimensions, distinguished according to their direct poten…

Momentum distributions of cosmic relics: Improved analysis

2022

We solve coupled momentum-dependent Boltzmann equations for the phase space distribution of cosmic relic particles, without resorting to approximations of assuming kinetic equilibrium or neglecting backscattering or elastic interactions. Our method is amendable to precision numerical computations. To test it, we consider two benchmark models where the momentum dependence of dark matter distribution function is potentially important: a real singlet scalar extension near the Higgs resonance and a sterile neutrino dark matter model with a singlet scalar mediator. The singlet scalar example shows that the kinetic equilibrium may hold surprisingly well even near sharp resonances. However, the in…

L’impatto del burnout, ansia e disturbi del sonno sulla qualità della vita degli infermieri di area critica: un protocollo di ricerca.

2022

Introduzione: La Qualità della Vita, viene definita dall’Organizzazione Mondiale della Sanità come “La percezione dell’individuo della propria posizione nella vita nel contesto dei sistemi culturali e dei valori di riferimento nei quali è inserito e in relazione ai propri obiettivi, aspettative, standard e interessi”. In relazione alla categoria infermieristica emerge un dato poco incoraggiante dalla letteratura internazionale; soltanto il 3,6% di essa è soddisfatta della propria attività lavorativa e professionale, inoltre in larga misura gli infermieri ritengono che molti aspetti della propria qualità della vita siano poco soddisfacenti. Materiale e metodi: Studio osservazionale multicent…

Spread of Multidrug-Resistant Microorganisms

2022

Multidrug-resistant organisms (MDRO) are bacteria that exhibit acquired resistance to multiple antibiotics, reducing the efficacy of antimicrobial therapies [...]