Uno studio sulla “dissenting opinion” con particolare riguardo all’esperienza del diritto inglese

2023

The essay explores the many means through which judicial dissent has traditionally made its way into the English legal system in order to be finally accepted as an ineliminable instrument that the minority has availed itself of to air its differing opinion, mostly in matters of general, public importance. So, the research is in the first place directed towards the identification of the different types of dissent and of the forms (even concurring) in which it may be shaped. Furthermore, the study involves the attempt to find out what reasons may underlie the expression of dissent and whether they may conceal some kind of idyiosincratic state of mind on the part of the dissenters. A view is a…

The three facets of the SARS-CoV-2 pandemic during the first two waves in the northern, central, and southern Italy

2023

Background: There is a scarcity of information in literature regarding the clinical differences and comorbidities of patients affected by Coronavirus disease 2019 (COVID-19), which could clarify the different prevalence of the outcomes (composite and only death) between several Italian regions. Objective: This study aimed to assess the heterogeneity of clinical features of patients with COVID-19 upon hospital admission and disease outcomes in the northern, central, and southern Italian regions. Methods: An observational cohort multicenter retrospective study including 1210 patients who were admitted for COVID-19 in Infectious diseases, Pulmonology, Endocrinology, Geriatrics and Internal Med…

Effect of hydrothermal time on the forming specific morphology of YPO4:Eu3+ nanoparticles for dedicated luminescent applications as optical markers

2023

A way to control the desired shape and microstructure of YPO4:Eu3+ nanoparticles through the precipitation method followed by a hydrothermal treatment is reported. This method is useful for achieving very high control over the YPO4:Eu3+ formation process with the selection of appropriate synthesis parameters. In detail, the autoclave processing time allows control of the shape and size of nano-needle-shaped particles independently in both directions, as confirmed by X-ray powder diffraction, FT-IR Spectroscopy and Electron Transmission Microscopy. In order to analyse the effect of the nanoparticles’ surroundings on the excitation and relaxation processes of luminescent ions, Eu3+ ion was us…

Frozen or dynamic? : An atomistic simulation perspective on the timescales of electrochemical reactions

2023

Electrochemical systems span a wide range of timescales, and several recent works have put forth the idea that the reaction environment should remain frozen and out of equilibrium during electrochemical electron or proton transfer reactions. Furthermore, simplified treatments of the electrochemical interface model the solvent and ions as frozen molecules. However, the claims and practices of a frozen environment strongly clash with most theoretical and simulation approaches developed to study electrochemical reaction rates. It has also been suggested that the electrode potential should not be fixed when simulating reaction rates due to conductivity limitations, which indicates constant pote…

Postural and gestural synchronization, sequential imitation, and mirroring predict perceived coupling of dancing dyads

2023

Body movement is a primary nonverbal communication channel in humans. Coordinated social behaviors, such as dancing together, encourage multifarious rhythmic and interpersonally coupled movements from which observers can extract socially and contextually relevant information. The investigation of relations between visual social perception and kinematic motor coupling is important for social cognition. Perceived coupling of dyads spontaneously dancing to pop music has been shown to be highly driven by the degree of frontal orientation between dancers. The perceptual salience of other aspects, including postural congruence, movement frequencies, time-delayed relations, and horizontal mirrorin…

Application of machine learning algorithms in thermal images for an automatic classification of lumbar sympathetic blocks

2023

Purpose There are no previous studies developing machine learning algorithms in the classification of lumbar sympathetic blocks (LSBs) performance using infrared thermography data. The objective was to assess the performance of different machine learning algorithms to classify LSBs carried out in patients diagnosed with lower limbs Complex Regional Pain Syndrome as successful or failed based on the evaluation of thermal predictors. Methods 66 LSBs previously performed and classified by the medical team were evaluated in 24 patients. 11 regions of interest on each plantar foot were selected within the thermal images acquired in the clinical setting. From every region of interest, different t…

Evaluation of washout using subtraction MRI for the diagnosis of hepatocellular carcinoma in cirrhotic patients with spontaneously T1-hyperintense no…

2023

Purpose: The purpose of this study was to assess the value of subtraction imaging on post-arterial phase images (i.e., portal venous, delayed/transitional and hepatobiliary phases) for the non-invasive diagnosis of hepatocellular carcinoma (HCC) in spontaneously hyperintense nodules on T1-weighted imaging in patients with cirrhosis. Materials and methods: Forty-five patients with a total 55 hepatic nodules that were spontaneously hyperintense on T1-weighted images were initially retrieved. All patients underwent MRI examination of the liver using extracellular agent. Each nodule was assessed for sensitivity and specificity using LI-RADS (Liver Imaging Reporting and Data System) during two r…

Tucidide e il marchese de Norpois. Memoria, obbligazione politica e ingratitudine

2023

This paper proposes some reflections on the problem of political ingratitude in international relations, particularly in the context of an imminent or already ongoing war. Recalling past benefits brings memory into play and emphasises the expectation produced by these benefits and the importance attached to the political obligations that should result from them. After providing some insights from Homer, attention will focus on Thucydides. Among the numerous case studies offered by the Athenian historian, particular attention will be paid to the conflict between Corcyra and Corinth in Book I and the political use of memory and gratitude in the speeches delivered in Athens by the ambassadors …

Paesaggi urbani a rischio. Sviluppo futuro delle città e Piano delle Acque, un legame imprescindibile

2023

Questo studio analizza il rapporto uomo-acqua-territorio, che nel tempo si è deteriorato fino a risultare quasi illeggibile. Una situazione accentuatasi in modo particolare negli ultimi decenni e senza dubbio ricollegabile all’eccessivo sviluppo delle concentrazioni urbane, ad un uso irrazionale del territorio, alla diffusione pervasiva delle più diverse forme di inquinamento, dalle manipolazioni sostanziali del paesaggio rurale ma, anche, dalla scarsa sensibilità di politici e amministratori che non hanno avuto la vision di saper programmare il futuro delle città. Ciò ha influenzato negativamente il reale ruolo dei corsi d’acqua, alterandone spesso le funzioni. Da qui la necessità di dover…

The Mathematical Table of the Palazzina Cinese in Palermo. Animation and Virtual Reality Techniques for an Edutainment Project

2023

The Palazzina Cinese of Palermo was built on a project by Venanzio Marvuglia in 1799 on behalf of Ferdinand IV of Borbone, when the royal family, fleeing from Naples following the establishment of the Parthenopean Republic, moved to Sicily. The building, known as “Chinese” due to its style, is full of particular architectural and decorative solutions. An element of particular interest is theMathematical Table, designed to avoid any contact between the living room and the kitchen below, isolating it from smells and servants. Thanks to a complex system of winches and pulleys, in fact, the dishes could be served by letting the central portion of the table and small circular areas fall into the…

Appreciation and rumination, not problem solving and avoidance, mediate the effect of optimism on emotional wellbeing

2023

Research suggests that optimism is positively related to emotional wellbeing. However, little is known about the emotion regulation mechanisms that potentially explain (i.e., mediate) this relationship. The present study was designed to address this issue. To this end, it examined emotion regulation strategies (i.e., appreciation, rumi nation, problem solving, and avoidance) that are theoretically and/or empirically related to optimism as possible mediators of the optimism-emotional wellbeing relationship. In the first of two phases, we established a baseline measure of dispositional optimism among 218 French adults. In the second phase, an experience sampling method was used to assess emot…

Association between internal load responses and recovery ability in U19 professional soccer players: A machine learning approach

2023

Background The objective of soccer training load (TL) is enhancing players’ performance while minimizing the possible negative effects induced by fatigue. In this regard, monitoring workloads and recovery is necessary to avoid overload and injuries. Given the controversial results found in literature, this study aims to better understand the complex relationship between internal training load (IL) by using rating of perceived exertion (RPE), recovery, and availability (i.e., subjective players’ readiness status). Methods In this cross-sectional study, twenty-two-professional soccer players (age: 18.5 ± 0.4 years, height: 177 ± 6 cm, weight: 67 ± 6.7 kg) competing in the U19 Italian Champion…

Influence of bundle porosity on shell-side hydrodynamics and mass transfer in regular fiber arrays: A computational study

2023

CFD predictions of the effects of a fiber bundle porosity on shell-side hydrodynamics and mass transfer under conditions of steady laminar flow were obtained. Fluid was assumed to flow around regular hexag-onal or square arrays of cylindrical fibers of different pitch to diameter ratios, yielding bundle porosities ranging from the theoretical minimum up to similar to 1. A large number of axial, transverse and mixed flow combinations were simulated by letting the axial and transverse flow Reynolds numbers and the trans-verse flow attack angle vary. Both fully developed and developing conditions (entrance effects) were con-sidered. The continuity and momentum equations, along with a transport…

AUTOPHAGY AND APOPTOSIS MODULATION BY AQUEOUS EXTRACTS FROM LEAVES AND RHIZOMES OF Posidonia oceanica ON HEPG2 HEPATOCARCINOMA CELLS

2023

Sex differences in neuromuscular disorders

2023

: The prevalence, onset, pathophysiology, and clinical course of many neuromuscular disorders (NMDs) may significantly differ between males and females. Some NMDs are more frequently observed in females, and characterized to show a higher grade of severity during or after the pregnancy. Meanwhile, others tend to have an earlier onset in males and exhibit a more variable progression. Prevalently, sex differences in NMDs have a familiar character given from genetic inheritance. However, they may also influence clinical presentation and disease severity of acquired NMD forms, and are represented by both hormonal and genetic factors. Consequently, to shed light on the distinctive role of biolog…

Virtual reality acceptance and commitment therapy intervention for social and public speaking anxiety : A randomized controlled trial

2023

Virtual reality (VR) offers new and flexible ways to provide psychological interventions. The aim of this study was to develop and investigate the effectiveness of a VR intervention based on acceptance and commitment therapy (ACT) for social and public speaking anxiety. ACT is a process-based approach that aims to (a) increase individuals’ abilities to handle difficult emotional and cognitive experiences and (b) develop the motivation required for change to occur. In this study, a sample of university students with social interaction or communication anxiety (N = 76; age M = 24.95, SD = 6.50, 69.7% females) was blindly randomized into a total of 2 h of VR ACT training (VRACT; n = 37) or a w…

Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treat…

2023

Background: The Prospective Lynch Syndrome Database (PLSD) collates information on carriers of pathogenic or likely pathogenic MMR variants (path_MMR) who are receiving medical follow-up, including colonoscopy surveillance, which aims to the achieve early diagnosis and treatment of cancers. Here we use the most recent PLSD cohort that is larger and has wider geographical representation than previous versions, allowing us to present mortality as an outcome, and median ages at cancer diagnoses for the first time.Methods: The PLSD is a prospective observational study without a control group that was designed in 2012 and updated up to October 2022. Data for 8500 carriers of path_MMR variants fr…

Le sculture lignee

2023

Il contributo indaga le sculture lignee ubicate nella chiesa di Santa Maria la Porta di Geraci Siculo. Si tratta di opere eseguite dal XVI al XVII secolo da scultori attestati non solo nel borgo madonita ma anche in altre realtà isolane. Ogni manufatto è collocato nella pertinente temperie culturale The contribution investigates the wooden sculptures located in the church of Santa Maria la Porta in Geraci Siculo. These are works performed from the 16th to the 17th century by sculptors attested not only in the Madonie village but also in other island realities. Each artifact is placed in the pertinent cultural climate

Multimorbidity increases the risk of dementia: a 15 year follow-up of the SHARE study.

2023

Abstract Aims the literature regarding the association between multimorbidity and dementia is still unclear. Therefore, we aimed to explore the potential association between multimorbidity at the baseline and the risk of future dementia in the SHARE (Survey of Health, Ageing and Retirement in Europe) study, a large European research survey, with a follow-up of 15 years. Methods in this longitudinal study, multimorbidity was defined as the presence of two or more chronic medical conditions, among 14 self-reported at the baseline evaluation. Incident dementia was ascertained using self-reported information. Cox regression analysis, adjusted for potential confounders, was run and hazard ratios…

The characteristics of patients with COVID-19-associated pediatric vasculitis: an international, multicenter study

2023

Objective: COVID-19-associated pediatric vasculitis, other than Kawasaki disease (KD)-like vasculitis in multisystem inflammatory syndrome in children (MIS-C), is very rare. This study sought to analyze the characteristics, treatment, and outcomes in patients with COVID-19-associated pediatric vasculitis (excluding KD-like vasculitis in MIS-C). Methods: The inclusion criteria were as follows: 1) age <18 years at vasculitis onset; 2) evidence of vasculitis; 3) evidence of SARS-CoV-2 exposure; and 4) ≤3 months between SARS-CoV-2 exposure and vasculitis onset. Patients with MIS-C were excluded. The features of the subset of patients in our cohort who had COVID-19-associated pediatric IgA vascu…

Mitochondrial cannabinoid receptors gate corticosterone impact on novel object recognition

2023

: Corticosteroid-mediated stress responses require the activation of complex brain circuits involving mitochondrial activity, but the underlying cellular and molecular mechanisms are scantly known. The endocannabinoid system is implicated in stress coping, and it can directly regulate brain mitochondrial functions via type 1 cannabinoid (CB1) receptors associated with mitochondrial membranes (mtCB1). In this study, we show that the impairing effect of corticosterone in the novel object recognition (NOR) task in mice requires mtCB1 receptors and the regulation of mitochondrial calcium levels in neurons. Different brain circuits are modulated by this mechanism to mediate the impact of cortico…

Collaborative Leadership in the Institution of Higher Education: A Sociocultural Context of Pakistan

2023

The need for collaborative leadership to advance knowledge sharing, novel ideas, inclusion and employee engagement has increased in modern organizations, with the aim being to make organizations more effective and responsible. Yet, an interesting question arises about how this kind of leadership model, which is arguably of Western origin, is understood and whether it can be applied in sociocultural contexts where top-down leadership tends to be exercised. This study addresses this question and explores the meaning of collaborative leadership from a cultural viewpoint in Pakistan, where collaborative relationships across hierarchical levels are not common. The applicability of collaborative…

Weight loss induces changes in adaptive thermogenesis in female and male physique athletes

2023

Physique athletes lose substantial weight preparing for competitions, potentially altering systemic metabolism. We investigated sex differences in body composition, resting energy expenditure (REE), and appetite-regulating and thyroid hormone changes during a competition preparation among drug-free physique athletes. The participants were female (10 competing (COMP) and 10 nondieting controls (CTRL)) and male (13 COMP and 10 CTRL) physique athletes. COMP were tested before they started their diet 23 weeks before competing (PRE), during their diet one week before competing (MID), and 23 weeks after competing (POST), whereas CTRL were tested at similar intervals but did not diet. Measurement…

Numerical procedures and their practical application in PV module analyses. Part III: parameters of atmospheric transparency – determining and correl…

2023

The presented article examines aspects of a PV module testing using natural sunlight in outdoor conditions. The article discusses the physical sense of indexes: atmosphere purity, diffused component content, beam clear sky index. Procedures for their determination are given in relation to both instantaneous and daily values. Their close connection with the values of solar irradiance spectral distribution such as Average Photon Energyand Useful Fractionis demonstrated, as well as their usefulness in moduletesting in outdoor conditions. Their influence on the conversion of modules made from various absorbers and various technologies is demonstrated

Beliefs and attitudes of Australian learner drivers toward driving and avoiding driving through floodwater

2023

Driving through floodwater is a significant cause of flood-related injury and mortality, and opportunities exist to embed safe driving messages regarding floodwaters to novice drivers in graduated driver licensing schemes. To inform future educational efforts, we investigated the beliefs and attitudes of Australian learner drivers about driving and avoiding driving through floodwaters. Methods: The study adopted a cross-sectional correlational design with measures drawn from the theory of planned behaviour and administered within an online survey. Phase 1 (N = 44 learner drivers) aimed to identify the core beliefs associated with driving through floodwater. Phase 2 (N = 250 learner drivers)…

A new strategy to assure compliance with soil loss tolerance at a regional scale

2023

The relevant erosive effects of extraordinary rainfall events due to climate change require establishing soil conservation strategies to prevent damages due to hydrogeological instability. The “tolerable” soil loss, i.e., the maximum soil loss compatible with sustainable soil use, represents a quantitative target to establish the effectiveness of actions to control soil erosion. In this paper, a new approach to defining the condition corresponding to a tolerable soil loss is proposed. At first, using the statistical analysis of the measured annual values of the rainfall erosivity factor, the cover and management factor CT, for which the maximum tolerable soil loss is equal to the annual soi…

Formare docenti creativi per costruire una società democratica e inclusiva

2023

Questo contributo si ispira a Mario Lodi e alla sua concezione della scuola come luogo potenziale in cui scoprire, nell’età dello sviluppo, le proprie capacità ma anche le proprie preferenze e i propri desideri e, nello stesso tempo, come contesto in cui sperimentare la dimensione comunitaria e di gruppo per potere divenire adulti consapevoli e attenti al bene comune. Il termine “potenziale” è utilizzato perché la scuola può non arrivare ad assolvere il suo compito ma, al contrario, contribuire a conformare il pensiero, a diffondere una cultura della competizione e a perpetuare le disuguaglianze. Benchè ci siano stati sicuramente cambiamenti significativi, legati anche alle trasformazioni s…

Chronic brain damage in HIV-infected individuals under antiretroviral therapy is associated with viral reservoirs, sulfatide release, and compromised…

2023

HIV infection has become a chronic and manageable disease due to the effective use of antiretroviral therapies (ART); however, several chronic aging-related comorbidities, including cognitive impairment, remain a major public health issue. However, these mechanisms are unknown. Here, we identified that glial and myeloid viral reservoirs are associated with local myelin damage and the release of several myelin components, including the lipid sulfatide. Soluble sulfatide compromised gap junctional communication and calcium wave coordination, essential for proper cognition. We propose that soluble sulfatide could be a potential biomarker and contributor to white matter compromise observed in H…

Memoria, spazio, identità. Una premessa

2023

Memory, which has always been a subject of research and reflection, entered by right with Émile Durkheim and Marcel Mauss into the space of 'total social facts', i.e. the group of those aspects of human behaviour that support the ideological structure of social universes and regulate the capacity to perform a given action, regardless of intentionality, of both individuals and groups. What emerges is the problematic nature of the very nature of memory and its relationship to history and historians.

Synergistic effects of childhood adversity and polygenic risk in first-episode psychosis

2023

The European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) Project is funded by grant agreement HEALTH-F2-2010-241909 (Project EU-GEI) from the European Community’s Seventh Framework Programme.

Recent Developments and Formulations for Hydrophobic Modification of Carrageenan Bionanocomposites

2023

Versatility of the anionic algal polysaccharide carrageenan has long been discussed and explored, especially for their affinity towards water molecules. While this feature is advantageous in certain applications such as water remediation, wound healing, etc., the usefulness of this biopolymer is extremely limited when it comes to applications such as food packaging. Scientists around the globe are carrying out research works on venturing diverse methods to integrate hydrophobic nature into these polysaccharides without compromising their other functionalities. Considering these foregoing studies, this review is designed to have an in-depth understanding of diverse methods and techniques ado…

Phosphorous removal from human urine using lateritic soil

2023

Phosphorous (P) in human urine is among the macronutrients in municipal wastewater that has exacerbated eutrophication of water bodies. Adsorption of P from wastewater using cost effective, environmentally friendly, and efficient adsorbents is considered as an attractive method that can both mitigate the eutrophication problem and augment the already strained P reserves. In the present study the adsorption capacity and structural properties of lateritic soil (LS), the adsorbent for removal of P from human urine, was investigated using XRF, SEM, TGA and FTIR techniques. Batch adsorption experiments were conducted to determine various adsorption parameters such as the sorption rates, the conc…

Lynch Syndrome Genetics and Clinical Implications

2023

Lynch syndrome (LS) is one of the most prevalent hereditary cancer syndromes in humans and accounts for some 3% of unselected patients with colorectal or endometrial cancer and 10%-15% of those with DNA mismatch repair-deficient tumors. Previous studies have established the genetic basis of LS predisposition, but there have been significant advances recently in the understanding of the molecular pathogenesis of LS tumors, which has important implications in clinical management. At the same time, immunotherapy has revolu-tionized the treatment of advanced cancers with DNA mismatch repair defects. We aim to review the recent prog-ress in the LS field and discuss how the accumulating epidemiol…

Comparisonof the effects of six-week time-restricted eating on weight loss, body composition, and visceral fat in overweight older men and women

2023

The aim of this study was to determine the effectiveness of a six-week time-restricted eating (TRE) intervention in reducing body weight, fat loss, and visceral fat in overweight, older adult men and women (age range = 65-74 years). Another objective was to determine the feasibility of widespread use of TRE in older women and men. The study randomly assigned 116 healthy, non-smoking participants to one of two conditions: TRE or educational control participants. Participants in the TRE group were instructed to not consume calorie containing beverages or food for 16 h per day, from 8:00 pm to 12:00 pm. Participants in the control group were instructed to follow a meal plan based on their prev…

The effects of short-term glyphosate-based herbicide exposure on insect gene expression profiles

2023

Glyphosate-based herbicides (GBHs) are the most frequently used herbicides worldwide. The use of GBHs is intended to tackle weeds, but GBHs have been shown to affect the life-history traits and antioxidant defense system of invertebrates found in agroecosystems. Thus far, the effects of GBHs on detoxification pathways among invertebrates have not been sufficiently investigated. We performed two different experiments—1) the direct pure glyphosate and GBH treatment, and 2) the indirect GBH experiment via food—to examine the possible effects of environmentally relevant GBH levels on the survival of the Colorado potato beetle (Leptinotarsa decemlineata) and the expression profiles of their deto…

Approximation through suffixation:-ḍḍu/-a in Sicilian

2023

This article investigates the use of the Sicilian suffix -ḍḍu/-afor the expression of ap-proximation. On the basis of a survey of a corpus of ethnotexts and the outputs of a translation questionnaire, we propose that approximation is a core value in the semantic network of the suffix, expressing a certain distance fromthe default values conveyed by the base. In terms of prototypi-cality, this distance may occur from the categorial centre (internal approximation): the suffix mod-ifies the semantics of the base but does not alter the categorial status of the referent. Alternatively, the suffix may impact on categorial membership tout court (external approximation), questioning the categorial …