Effect of Calcifediol on Physical Performance and Muscle Strength Parameters: A Systematic Review and Meta-Analysis

2022

There is general agreement that optimal vitamin D status is necessary for bones, muscles, and general health, particularly in older adults, who are at higher risk of negative consequences of vitamin D deficiency, including sarcopenia; vitamin D supplementation is proposed as a potential intervention to mitigate sarcopenia. Several RCTs have reported that calcifediol (25(OH)D) was more potent than cholecalciferol in increasing plasma 25(OH)D. The present systematic review and meta-analysis aimed to summarize the effects of calcifediol on physical performance and muscle strength. We searched databases from inception to 1 January 2022 for studies investigating calcifediol on physical performan…

Carfilzomib combined with lenalidomide and dexamethasone (KRd) as salvage therapy for multiple myeloma patients: italian, multicenter, retrospective …

2022

In combination with lenalidomide and dexamethasone (KRd), Carfilzomib has been approved for the treatment of relapsed and refractory multiple myeloma (RRMM) on ASPIRE trial. Efficacy and safety of the triplet are still the object of investigation by many groups to confirm ASPIRE results in the setting of RRMM treated in real-life who don't meet trial restrictive inclusion criteria. Therefore, we report a retrospective multicenter analysis of 600 RRMM patients treated with KRd between December 2015 and December 2018. The median age was 64 years (range 33-85), and the median number of previous therapies was two (range 1-11). After a median of 11 KRd cycles, the overall response rate was 79.9%…

Epidemiological Survey of Grapevine Leafroll-Associated Virus 1 and 3 in Sicily (Italy): Genetic Structure and Molecular Variability

2022

Background: the most widely distributed and virulent Grapevine leafroll-associated viruses (GLRaV) that affect grapevine are GLRaV-1 and GLRaV-3, transmitted semi-persistently by different mealybugs and soft scales, mainly causing downward rolling of the leaf margins and interveinal reddening. Methods: the main objectives of this study were to investigate the genetic structure and molecular diversity of GLRaV-1 and GLRaV-3 in 617 samples from 11 autochthonous Sicilian grapevine cultivars, ascertaining their presence and spread. The detection was implemented by serological and molecular analyses and subsequently phylogenetic analyses on selected Sicilian isolates were conducted. Results: in …

Persistence in complex systems

2022

Persistence is an important characteristic of many complex systems in nature, related to how long the system remains at a certain state before changing to a different one. The study of complex systems' persistence involves different definitions and uses different techniques, depending on whether short-term or long-term persistence is considered. In this paper we discuss the most important definitions, concepts, methods, literature and latest results on persistence in complex systems. Firstly, the most used definitions of persistence in short-term and long-term cases are presented. The most relevant methods to characterize persistence are then discussed in both cases. A complete literature r…

A lift in snail's gut provides an efficient colonization route for tardigrades.

2022

Latent burnout profiles in a sample of frontline healthcare professionals after the peak of the Italian COVID-19 pandemic

2022

Background: In Italy since February 2020, the unexpected massive afflux of COVID-19 patients exposed healthcare professionals to high work-related stress, high time pressure and increased the risk of being infected. This is the first study that aimed to investigate the psychological impact of COVID-pandemic at the end of the peak, by identifying latent burnout profiles in a sample of front-line healthcare professionals that worked in Italy during the peak of the pandemic. Methods: A total of 589 subjects filled in an online ad-hoc questionnaire and the Italian version of Maslach Burnout Inventory - Human Services Survey. Results: A higher presence of burnout profile in healthcare profession…

Epidemiology, monitoring, and treatment strategy in cardiogenic shock. A multinational cross-sectional survey of ESC-acute cardiovascular care associ…

2022

Abstract Aims Cardiogenic shock (CS) is a life-threatening condition burdened by mortality in up to 50% of cases. Few recommendations exist with intermediate–low level of evidence on CS management and no data on adherence across centres exist. We performed a survey to frame CS management at multinational level. Methods and results An international cross-sectional survey was created and approved by European Society of Cardiology-Acute Cardiovascular Care Association board. A total of 337 responses from 60 countries were obtained. Data were assessed by the hospital level of care of the participants. The most common cause of CS was AMI (AMI-CS—79.9%) with significant difference according to ho…

Managing the Systemic Impact of Periodontitis

2022

Periodontitis is a microbially driven host-mediated disease that leads to loss of periodontal attachment and bone. It is associated with elevation of systemic inflammatory markers and with the presence of systemic co-morbidities. Furthermore, periodontal treatment leads to a 24–48 h-long acute local and systemic inflammatory response. This systemic response might increase the burden of patients with compromised medical history and/or uncontrolled systemic diseases. The correlation between periodontitis and systemic diseases, the impact of periodontitis on the quality of life and public health, the effects of periodontal treatment on systemic health and disease, and the available methods to …

Lipas-data 04/2022

2022

Tämä aineisto sisältää kaikki Lipas-tietokannan liikuntapaikat ja aineistotiedot 29.4.2022. Data on luokiteltu, ja jokaiselle liikuntapaikalle on oma Lipas-ID. Data on tarjolla Esri Shapefile -muodossa (pisteet, reitit ja alueet). This data includes all sport facilities in Lipas database on 29.4.2022 and basic attribute information about the places. The data is classified and each sport facility has its own Lipas ID. The data is provided as Esri Shapefiles (points, routes and areas) in Finnish, Swedish and English.

Inferring Population Structure from Early Life Stage: The Case of the European Anchovy in the Sicilian and Maltese Shelves

2022

The European anchovy is an important fishing resource in the Sicilian Channel that supports a high recruitment success variability. The presence of two spawning areas, the drifting of the larvae along the currents and the different oceanographic conditions within the region suggest the presence of different larvae subpopulations. Morphometric and biochemical approaches have been used to analyze the differences among larvae collected. The amino acid composition discriminates two larval groups closely related to the spawning regions: Adventure Bank and the shelf between the South of Sicily and Malta. In addition, there are morphometric and growth differences between recently hatched larvae in…

Real-Time Detection of Incipient Inter-Turn Short Circuit and Sensor Faults in Permanent Magnet Synchronous Motor Drives Based on Generalized Likelih…

2022

This paper presents a robust model-based technique to detect multiple faults in permanent magnet synchronous motors (PMSMs), namely inter-turn short circuit (ITSC) and encoder faults. The proposed model is based on a structural analysis, which uses the dynamic mathematical model of a PMSM in an abc frame to evaluate the system’s structural model in matrix form. The just-determined and over-determined parts of the system are separated by a Dulmage–Mendelsohn decomposition tool. Subsequently, the analytical redundant relations obtained using the over-determined part of the system are used to form smaller redundant testable sub-models based on the number of defined fault terms. Furthermore, fo…

An Efficient Online/Offline Signcryption Scheme for Internet of Things in Smart Home

2022

The delivery of unified intelligent services is accomplished through a networked environment comprised of a wide array of electronic devices. Through the use of Internet of Things (IoT) technology, smart homes collect data from their surroundings and use it to improve their tenants’ lives. Remote control, real-time monitoring, and a fire alarm are all characteristics of smart home security. Since smart homes hold personally identifying information about their residents, security is critical to ensure their reliability and prevent data breaches. In this paper, a certificateless online/offline signcryption (COOS) technique for IoT-enabled smart homes is proposed. The proposed solution takes a…

UNE DECENNIE DE RECHERCHES SUR LE SITE ARCHÉOLOGIQUE DE LA COURONNE À MOLLES !UNE FORTERESSE DE LA FIN DE L’ANTIQUITÉ ET DU HAUT MOYEN ÂGE DANS LES C…

2022

International audience

Influence of health literacy on maintenance of exclusive breastfeeding at 6 months postpartum: a multicentre study

2022

Data Availability Statement: Please note that the database is in an open repository. You can access the data through this link: http://hdl.handle.net/10234/196606 (accessed on 20 February 2022). Copyright © 2022 by the authors. Background: International organizations recommend initiating breastfeeding within the first hour of life and maintaining exclusive breastfeeding for the first 6 months. However, worldwide rates of exclusive breastfeeding for 6-month-old infants is far from meeting the goal proposed by the World Health Organization, which is to reach a minimum of 50% of infants. Education is one of the factors affecting the initiation and continuation of breastfeeding, and incidentall…

Computational Rationality as a Theory of Interaction

2022

Funding Information: This work was funded by the Finnish Center for AI and Academy of Finland (“BAD” and “Human Automata”). We thank our reviewers, Xiuli Chen, Joerg Mueller, Christian Guckelsberger, Sebastiaan de Peuter, Samuel Kaski, Pierre-Alexandre Murena, Antti Keuru-lainen, Suyog Chandramouli, and Roderick Murray-Smith for their comments. Publisher Copyright: © 2022 ACM. How do people interact with computers? This fundamental question was asked by Card, Moran, and Newell in 1983 with a proposition to frame it as a question about human cognition - in other words, as a matter of how information is processed in the mind. Recently, the question has been reframed as one of adaptation: how …

Modified Atmosphere Packaging and low temperature storage extend marketability of cherimoya (Annona cherimola Mill.)

2022

Cherimoya is a subtropical fruit characterized by a delicious, sweet flavor and beneficial health properties, which found suitable growing conditions in the South of Italy. However, the marketing of this product is halted by its high perishability, which limits the shelf-life of the fresh fruit to few days after harvest and does not allow for commercialization beyond local markets. Studies have shown that storage of this fruit in controlled atmosphere, using Modified Atmosphere Packaging technologies, extended the post-harvest life of Cherimoya, but little is still known about the evolution of its sensory, nutraceutical and microbiological characteristics during such storage period. In this…

Weighted Single-Step Genome-Wide Association Study Uncovers Known and Novel Candidate Genomic Regions for Milk Production Traits and Somatic Cell Sco…

2022

The objective of this study was to uncover genomic regions explaining a substantial proportion of the genetic variance in milk production traits and somatic cell score in a Valle del Belice dairy sheep. Weighted single-step genome-wide association studies (WssGWAS) were conducted for milk yield (MY), fat yield (FY), fat percentage (FAT%), protein yield (PY), protein percentage (PROT%), and somatic cell score (SCS). In addition, our aim was also to identify candidate genes within genomic regions that explained the highest proportions of genetic variance. Overall, the full pedigree consists of 5534 animals, of which 1813 ewes had milk data (15,008 records), and 481 ewes were genotyped with a …

Screening for Low Energy Availability in Male Athletes: Attempted Validation of LEAM-Q

2022

A questionnaire-based screening tool for male athletes at risk of low energy availability (LEA) could facilitate both research and clinical practice. The present options rely on proxies for LEA such screening tools for disordered eating, exercise dependence, or those validated in female athlete populations. in which the female-specific sections are excluded. To overcome these limitations and support progress in understanding LEA in males, centres in Australia, Norway, Denmark, and Sweden collaborated to develop a screening tool (LEAM-Q) based on clinical investigations of elite and sub-elite male athletes from multiple countries and ethnicities, and a variety of endurance and weight-sensiti…

Search for X(3872)→π0χc0 and X(3872)→ππχc0 at BESIII

2022

Burnout and Online Medical Education: Romanian Students in Lockdown and Their Residency Choices.

2022

The primary aim of the study was to investigate the prevalence of burnout in Romanian medical students during the COVID-19 pandemic using the Maslach Burnout Inventory-General Survey for Students (MBI-GS(S)). The presence of burnout was assessed based on Exhaustion (EX), Cynicism (CY) and Professional Efficacy (PE) subscales. The secondary aim of the study was to identify the presence of intentional shift in medical specialty compared to their initial pursued choice within the population investigated. Data was collected online at the end of 2020 and beginning of 2021 through a licensed, customized MBI-GS(S) questionnaire from a sample of 126 Romanian medical students at the two leading medi…

Interest Representation Preconditions in Illiberal Poland and Hungary

2022

Poland and Hungary have been widely recognised as countries affected by illiberalism. This has undoubtedly created a challenging environment for interest groups; groups which are a touchstone for the quality of democratic processes. In this article, we aim to understand how preconditions for interest representation have changed due to illiberal drift through the eyes of interest groups operating in these two selected post-communist countries. In order to examine their perception of opportunity structures, interaction infrastructure as well as the level of political coordination under the new circumstances, we rely on quantitative research in the form of a survey carried out among interest g…

Use of Battery- vs. Petrol-Powered Chainsaws in Forestry: Comparing Performances on Cutting Time

2022

The use of battery tools is very common in many fields of work. In fact, the electric engine and batteries have several advantages over traditional endothermic engines, including low emissions, in terms of pollutants, vibration and noise. In this context, the chainsaw market started producing electric models powered by batteries. These machines can be useful in forestry, but information on their performance is scarce. The aim of this work was to compare the performance, in terms of cutting times, of three Stihl chainsaw models: the MS 220C-B (battery powered), and the MS 201 C-M and MS 261 C-M (both petrol powered). The study was carried out on five different wood species, also taking into …

Focal liver lesions in cirrhosis: Role of contrast-enhanced ultrasonography

2022

Contrast-enhanced ultrasound (CEUS) represents a great innovation for the evaluation of focal liver lesions (FLLs). The main advantage of CEUS is the real-time imaging examination and the very low toxicity in patients with renal failure. Liver cirrhosis has been recognized as a major risk factor for the onset of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). HCC in liver cirrhosis develops as the last step of a complex that leads to the gradual transformation from regenerative nodule through dysplastic nodule to HCC. In patients with liver cirrhosis, a surveillance program is recommended consisting of ultrasound (US) for detecting small focal lesions. A wide spect…

Obbligo vaccinale e discrezionalità legislativa a proposito delle ordinanze CGARS nn.38 e 351 del 2022

2022

The paper deals with two ordinances of the CGARS on the subject of vaccination obligation, retracing the events that first led to the preliminary order no. 38/2022 and then to the reasoned order for referral to the constitutional court.

EntityBot: Actionable Entity Recommendations for Everyday Digital Task

2022

Our everyday digital tasks require access to information from a wide range of applications and systems. Although traditional search systems can help find information, they usually operate within one application (e.g., email client or web browser) and require the user's cognitive effort and attention to formulate proper search queries. In this paper, we demonstrate EntityBot, a system that proactively provides useful and supporting entities across application boundaries without requiring explicit query formulation. Our methodology is to exploit the context from screen frames captured every 2 seconds to recommend relevant entities for the current task. Recommendations are not restricted to on…

Atomically resolved TEM imaging of covalently functionalised graphene

2022

AbstractCovalent functionalisation can be a powerful lever to tune the properties and processability of graphene. After overcoming the low chemical reactivity of graphene, covalent functionalisation led to the generation of new hybrid materials, applicable in a broad variation of fields. Although the process of functionalising graphene is nowadays firmly established, fundamental aspects of the produced hybrid materials remain to be clarified. Especially the atomically resolved imaging is only scarcely explored. Here we show aberration corrected in situ high resolution TEM imaging of dodecyl functionalised monolayer graphene at atomic resolution after an effective mechanical filtering approa…

Can Nationality Explain Economic Tourist Behaviour? A Thematic Review

2022

Numerous studies focus on the determinants of choices regarding tourism consumption utilizing several methods, different data sources, with diverse results. And the notion of considering nationality as an influential factor in tourism expenditure has been considered very often in the literature. This work examines this relationship between nationality and tourism expenditure by means of a thematic review approach. The results suggest the critical role played by nationality in understanding the determinants of tourism expenditure.

Theory for polaritonic quantum tunneling

2022

I investigate the tunneling decay rate of a polaritonic system formed by a strong coupling between a vacuum cavity mode and $N$ metastable systems. Using a simple model potential, I find the instanton solutions controlling the low-temperature tunneling rate. The resulting rate modification due to the cavity is proportional to the mean of the second power of the light-matter coupling. No collective effect that would enhance the rates by a factor of $\sqrt{N}$ is present, which is in line with the results in the thermal activation regime.

Girls’ portrayals in fast fashion advertisements

2022

This study analyses the visual construction of girls and notionssurrounding young femininities articulated by 15 contemporaryadvertisements of Nordic fast fashion companies, available on theirpublic Facebook pages in Finland. A visual discourse analysis identifiessome blatantly stereotypical and a few complex visual constructions ofgirls as heterosexual, caring, innocent, sexy posers, active self-presentersand self-surveyors, carefree and environmental activists. Theimplications of our findings, particularly in shaping societal notionssurrounding girls, are discussed. The study contributes primarily to theresearch field of visual commercial representation of girls by unpackinghow their comp…

Associations of Children’s Close Reading Distance and Time Spent Indoors with Myopia, Based on Parental Questionnaire

2022

Purpose: To study the association of parents’ reports about their children’s near work and outdoor habits with myopia in their children. Methods: Data from a questionnaire study conducted in 1983 among Finnish schoolchildren were reanalyzed. Vision screening had been performed for all the schoolchildren (n = 4961) in the 1st, 5th, and 8th grades (7-, 11-, and 15-year-olds) in an area of Central Finland. The questionnaire, including information about myopia, was returned by 4305 (86.7%) participants. Items concerned parents’ estimates of their child’s habitual reading distance, time spent indoors as compared with age peers, daily near work, outdoors time, and parents&…

Recent Approaches to Determine Static and Dynamic Redox State-Related Parameters

2022

Oxidative stress refers to an imbalance between oxidant and antioxidant molecules, which is usually associated with oxidative damage to biomolecules and mitochondrial malfunction. Redox state-related parameters include (1) the direct measurement of ROS, (2) the assessment of the antioxidant defense status, and (3) the analysis of the resulting oxidative damage to molecules. Directly measuring ROS appears to be the preferred method among scientists, but most ROS are extremely unstable and difficult to measure. The processes of determining both the oxidative damage to biomolecules and the antioxidant system status, although both are indirect approaches, provide a reliable method to measure ox…

Non-melancholic depressive symptoms are associated with above average fat mass index in the Helsinki birth cohort study

2022

AbstractThere is an existing link between two of the most common diseases, obesity and depression. These are both of great public health concern, but little is known about the relationships between the subtypes of these conditions. We hypothesized that non-melancholic depressive symptoms have a stronger relationship with both body composition (lean mass and fat mass) and dysfunctional glucose metabolism than melancholic depression. For this cross-sectional study 1510 participants from the Helsinki Birth Cohort Study had their body composition evaluated as lean mass and fat mass (Lean Mass Index [LMI, kg/m2] + Fat Mass Index [FMI kg/m2] = Body Mass Index). Participants were evaluated for dep…

Review Essay : Mountains, History, and Nature : A View Back from the Anthropocene Towards Historical Mountaineering Literature

2022

Review essay of Caroline Schaumann’s Peak Pursuits: The Emergence of Mountaineering in the Nineteenth Century and of the anthology edited by Sean Ireton and Caroline Schaumann, Mountains and the German Mind: Translations from Gessner to Messner.

Comparison of Nonclassic and Classic Phenotype of Hypertrophic Cardiomyopathy Focused on Prognostic Cardiac Magnetic Resonance Parameters: A Single-C…

2022

Patients with nonclassic phenotypes (NCP)—more advanced stages of hypertrophic cardiomyopathy (HCM)—constitute an intriguing and heterogeneous group that is difficult to diagnose, risk-stratify, and treat, and often neglected in research projects. We aimed to compare cardiac magnetic resonance (CMR) parameters in NCP versus classic phenotypes (CP) of HCM with special emphasis given to the parameters of established and potential prognostic importance, including numerous variables not used in everyday clinical practice. The CMR studies of 88 patients performed from 2011 to 2019 were postprocessed according to the study protocol to obtain standard and non-standard parameters. In NCP, the late …

The Construction of Ideological and Political Education in Higher Vocational Schools Based on Smartphone Carriers

2022

In the age of technology, artificial intelligence has reached new heights. The growth of the educational system has also evolved with technological growth. In this research, people are going to study the construction of ideological and political education in higher vocational schools based on smartphone carriers. The use of smartphones is becoming more common and unavoidable due to the growth of Internet technology, cloud technology, and wireless technology. The availability of 4G and 5G technologies supports all the relevant and nonrelevant industries to utilize this growth. The field of education has also adapted to this new age of technology by implementing online classes that replace cl…

Learning to Cycle : A Cross-Cultural and Cross-Generational Comparison

2022

BackgroundLearning to cycle is an important milestone for children, but the popularity of cycling and the environmental factors that promote the development and practice of this foundational movement skill vary among cultures and across time. This present study aimed to investigate if country of residence and the generation in which a person was born influence the age at which people learn to cycle.MethodsData were collected through an online survey between November 2019 and December 2020. For this study, a total of 9,589 responses were obtained for adults (self-report) and children (parental report) living in 10 countries (Portugal, Italy, Brazil, Finland, Spain, Belgium, United Kingdom, M…