The effect of cannabinoid receptor agonist WIN 55,212-2 on anxiety-like behavior and locomotion in a genetic model of absence seizures in the elevate…

2022

GAERS and NEC rats were treated with cannabinoid 1/2 receptor agonist WIN 55,212-2 2 mg/kg and tested on the Elevated Plus-Maze

Neutrophil extracellular traps arm DC vaccination against NPM-mutant myeloproliferation

2022

Neutrophil extracellular traps (NETs) are web-like chromatin structures composed by dsDNA and histones, decorated with antimicrobial proteins. Their interaction with dendritic cells (DCs) allows DC activation and maturation toward presentation of NET-associated antigens. Differently from other types of cell death that imply protein denaturation, NETosis preserves the proteins localized onto the DNA threads for proper enzymatic activity and conformational status, including immunogenic epitopes. Besides neutrophils, leukemic cells can release extracellular traps displaying leukemia-associated antigens, prototypically mutant nucleophosmin (NPMc+) that upon mutation translocates from nucleolus …

Hope You’re Not Totally Commercial! : Toward a Better Understanding of Advertising Recognition's Impact on Influencer Marketing Effectiveness

2022

Social media influencers (SMIs) have become an effective channel for reaching targeted customers. The present study explores the influence process of advertising recognition on consumer responses in the SMI marketing context. The authors examined an Instagram post featuring the endorsement of a brand and created an experimental design with four conditions related to advertising recognition and the parasocial relationship. Findings from a partial least squares structural equation modeling procedure indicate that advertising recognition results in overall negative consumer responses to SMI brand endorsements. The results also indicate parallel mediating effects of source credibility and atti…

Exploring Changes in Fishery Emissions and Organic Carbon Impacts Associated With a Recovering Stock

2022

International objectives for sustainable development and biodiversity conservation require restoring fish populations to healthy levels and reducing fishing impacts on marine ecosystems. At the same time, governments, retailers, and consumers are increasingly motivated to reduce the carbon footprint of food. These concerns are reflected in measures of the EU Common Fisheries Policy (CFP) and the CFP Reform Regulation, which highlighted a need to move from traditional single-stock management toward an ecosystem approach to fisheries management (EAF). Using publicly available landings and effort data combined with estimates of adult population biomass, we develop methods to explore the potent…

First record of Sphaeralcea bonariensis (Cav.) Griseb. (Malvaceae) as a casual alien species in the Mediterranean area

2022

Sphaeralcea bonariensis (Cav.) Griseb. is here reported for the first time as alien species in Italy and in the Mediterranean area. It is a perennial shrub native to Southern America, where it is often considered a ruderal species frequent in cultivated areas. It was found in a population of a few individuals within Opuntia ficus-indica groves of Rocca Palumba territory (Western Sicily). Actually, due to short-term observational period and the low number of plants, Sphaeralcea bonariensis should be considered as a casual species in Italy. The ecological characteristics of the growing stand and the consistency of the population, as well as the possible causes of its introduction, are briefly…

Energizing Collaborative Industry-Academia Learning: A Present Case and Future Visions

2022

AbstractIn Industry-Academia Collaborations (IAC) both academic, scientific research results and industrial practitioner findings and experiences are produced. Both types of knowledge should be gathered, codified, and disseminated efficiently and effectively. This paper investigates a recent (2014–2017) large-scale IAC R&D&I program case (Need for Speed, N4S) from a learning perspective. It was one of the programs in the Finnish SHOK (Strategic Centres of Science, Technology, and Innovation) system. The theoretical bases are in innovation management, knowledge management, and higher education (university) pedagogy. In the future, IAC projects should be more and more commonplace sinc…

Freedom, joy and wonder as existential categories of childhood – reflections on experiences and memories of outdoor play

2022

This study conveys how young adults reflect upon their childhood experiences and memories of outdoor play, friluftsliv and outdoor places. Inspired by a phenomenological approach, we conducted walking interviews in nature areas where they used to play as children, revisiting the same informants and places as in a research project 14 years earlier. Today the respondents emphasise the experience of freedom encompassing joy, wonder and communication with surrounding nature and people, associating it with autonomy and self-determination. Joy, wonder and communication in someone’s experience are subjective existential categories often used to characterise friluftsliv in outdoor education. Person…

An Effective Method to Model the Combustion Process in Spark Ignition Engines

2022

A numerical simulation is a fundamental tool in the design and optimization procedure of an Internal Combustion (IC) engine; since combustion is the process that mostly influences the engine performance, efficiency and emissions, an effective combustion submodel is fundamental. A simple, nonpredictive way to simulate the combustion evolution is to implement a mathematical function that reproduces the mass fraction burned (MFB) profile that is characterized by a sigmoidal trend; the most used for this purpose is the Wiebe function. In this article the authors propose a different mathematical model, a Dose-Response (DR) type function that shows some benefits when compared to the Wiebe functio…

Herbal Medications in Endodontics and Its Application—A Review of Literature

2022

Herbal products are gaining popularity in dental and medical practice nowadays due to their biocompatibility, higher antimicrobial activity, antioxidant and anti-inflammatory properties. Herbal medicine has experienced rapid growth in recent years due to its beneficial properties, ease of availability, and lack of side effects. As pathogenic bacteria become more resistant to antibiotics and chemotherapeutic agents, researchers are becoming more interested in alternative products and treatment choices for oral diseases. As a result, natural phytochemicals separated from plants and utilized in traditional medicine are suitable substitutes for synthetic chemicals. The aim of this review articl…

Cytotoxic capability and the associated proteomic profile of cell-free coelomic fluid extracts from the edible sea cucumber Holothuria tubulosa on He…

2022

Hepatocellular carcinoma (HCC) is an aggressive cancer histotype and one of the most common types of cancer worldwide. The identification of compounds that might intervene to restrain neoplastic cell growth appears imperative due to its elevated overall mortality. The marine environment represents a reservoir rich in bioactive compounds in terms of primary and secondary metabolites produced by aquatic animals, mainly invertebrates. In the present study, we determined whether the water-soluble cell-free extract of the coelomic fluid (CFE) of the edible sea cucumber Holothuria tubulosa could play an anti-HCC role in vitro by analyzing the viability and locomotory behavior, cell cycle distribu…

Facilitators and Barriers to the Sustainability of a School-Based Bullying Prevention Program.

2022

AbstractThe long-term sustainment of bullying prevention programs has rarely been investigated. This study addresses this gap by identifying facilitators and barriers to the systematic implementation of KiVa antibullying program in real-life conditions, after an evaluation trial. The study is based on focus group interviews with teachers from 15 Finnish primary schools implementing the KiVa program. The schools were selected based on the annual KiVa survey data, with the criteria of long-term involvement in delivering the program and reaching successful outcomes in terms of decreasing trends in bullying and victimization. By utilizing thematic analysis, we identified program-related, organi…

Real-world digital pathology: considerations and ruminations of four young pathologists

2022

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The role of emotion regulation and intolerance to uncertainty on the relationship between fear of COVID-19 and distress

2022

AbstractThe COVID-19 pandemic is increasing negative consequences on mental health around the globe. To date, research on what psychological factors could influence individuals’ distress is still scarce. The current study aims to test a multiple mediation model to examine the role of Intolerance of Uncertainty (IU) and emotional regulation (i.e., expressive suppression and cognitive reappraisal) as joint factors, which can increase understanding of psychological distress due to the COVID-19 outbreak. An online survey measuring fear of COVID-19, IU, emotional regulation, and psychological distress was administered to 3863 Italian adults (females 73.3%; Mage = 36.44; SD = 14.74) during lockdo…

In vitro marginal and internal adaptation of four different base materials used to elevate proximal dentin gingival margins

2022

There is still debate about the most appropriate restorative material category to relocate the proximal deep cervical margins, thus, this study aimed to compare the marginal and internal adaptation of four base materials used for deep margin elevation, and to evaluate each base material/overlying composite interface.Fifty six molars received class II cavities with dentin/cementum gingival margins. They were divided into four groups and their gingival margins were elevated using either; resin modified glass ionomer (RMGI), highly viscous conventional glass ionomer (HV-GIC), flowable bulk fill resin composite (Bulk Flow) and bioactive ionic resin (Activa). The rest of the cavities were comple…

Peer support in an outpatient clinic for people living with human immunodeficiency virus: a qualitative study of service users’ experiences

2022

Abstract Background Although human immunodeficiency virus (HIV) has become a manageable condition with increasing life expectancy, people living with HIV (PLHIV) are still often isolated from society due to stigma and discrimination. Peer support provides one avenue for increased social support. Given the limited research on peer support from the perspective of PLHIV, this study explored their experiences of peer support organised by healthcare professionals in an outpatient clinical setting. Methods The study used a qualitative, descriptive research design for an in-depth understanding of peer support provided to PLHIV in the context of outpatient clinics. Healthcare professionals contribu…

Spatial-temporal analysis of hospitalizations with death caused by oral cancer in Brazil and its correlation with the expansion of healthcare coverag…

2022

Oral cancer (OC) is a growing public health problem worldwide. In Brazil, the National Oral Health Policy, implemented in 2004, expanded access to oral health services and prioritized OC care. However, it is not known whether this expansion resulted in a reduction in hospital admissions with death. This study aimed to analyze the proportion of hospital admissions who progressed to death due to OC in Brazil from 2007 to 2019 and its correlation with the coverage of health services. This study is an ecological, longitudinal, and analytical study of hospital admissions with death due to OC recorded in the Brazilian Hospital Information System. The following analyses were performed: descriptive…

Local Spatial Log-Gaussian Cox Processes for seismic data

2022

AbstractIn this paper, we propose the use of advanced and flexible statistical models to describe the spatial displacement of earthquake data. The paper aims to account for the external geological information in the description of complex seismic point processes, through the estimation of models with space varying parameters. A local version of the Log-Gaussian Cox processes (LGCP) is introduced and applied for the first time, exploiting the inferential tools in Baddeley (Spat Stat 22:261–295, 2017), estimating the model by the local Palm likelihood. We provide methods and approaches accounting for the interaction among points, typically described by LGCP models through the estimation of th…

Polyester microplastic fibers in soil increase nitrogen loss via leaching and decrease plant biomass production and N uptake

2022

Abstract Microplastic contamination, like other global change factors, can induce effects on ecosystem functions and processes, affecting various soil biophysical properties. However, effects of such contaminants on nutrient cycles in agroecosystems are still poorly understood. We here performed two pot experiments to investigate the effect of polyester microplastic fibers (PMFs) on soil physical properties, nitrogen cycle, and plant performance in a maize-based agroecosystem. Moreover, we followed the N loss via leaching in soil contaminated or not with PMFs by simulating heavy rainfall events that mimic a future scenario of climate change. Our results show that soil contaminated with PMFs…

Nanorod orientation control by swift heavy ion irradiation

2022

Highly energetic ions have been previously used to modify the shape of metal nanoparticles embedded in an insulating matrix. In this work, we demonstrate that under suitable conditions, energetic ions can be used not only for shape modification but also for manipulation of nanorod orientation. This observation is made by imaging the same nanorod before and after swift heavy ion irradiation using a transmission electron microscope. Atomistic simulations reveal a complex mechanism of nanorod re-orientation by an incremental change in its shape from a rod to a spheroid and further back into a rod aligned with the beam. Highly energetic ions have been previously used to modify the shape of meta…

Qualitative analysis on the driving force behind upcycling practices associated with mobile applications: Circular economy perspective

2022

Funding for open access charge: Universidad de Granada/CBUA

Variables Determining Higher Home Care Effectiveness in Patients with Chronic Cardiovascular Disease

2022

The aim of this cross-sectional study was to analyze the variables that influence the effectiveness of home care in patients with chronic cardiovascular disease and their informal caregivers. The study was conducted in 193 patients and their 161 informal caregivers. The study used the WHOQOL-BREF Quality of Life Questionnaire, the health behavior inventory questionnaire (HBI), the Camberwell assessment of need short appraisal schedule (CANSAS) and the hospital anxiety and depression scale–modified (HADS–M) version. Spearman’s rank correlation coefficient test and logistic regression were used for analyses. Analysis of patients revealed an association between home care effe…

How to Enhance the Sharing of Cyber Incident Information via Fine-Grained Access Control

2022

Industry 4.0 and the ongoing digital transformation along with a large number interconnected machines anddevices increase the role of cybersecurity, cyber incident handling and incident response in the factories of the future (FoF). Cyber incident information sharing plays a major role when we need to formulate situational pictures about FoF operations and environment, and respond to cybersecurity threats related to e.g. the implementation of novel technologies. Sharing of incident information has a major drawback since it may reveal too much about the attack target, e.g. in the case of legacy systems and therefore restrictions may apply. We have developed a proof-of-concept service that co…

Geometrinen hahmottaminen sosiaalisena, vuorovaikutteisena ja kehollisena toimintana

2022

Matematiikan ja luonnontieteiden oppimista käsittelevässä tutkimuksessa on viime aikoina korostettu kehon, kognition ja vuorovaikutuksen läheistä yhteyttä. Tässä artikkelissa pohdimme, millä tavoin geometrinen hahmottaminen on sosiaalista, vuorovaikutteista ja materiaalien välittämää kehollista toimintaa. Tarkastelemme eräässä kouluajan ulkopuolella järjestetyssä STEAM-työpajassa kerättyä videoaineistoa keskustelunanalyysin menetelmin. Työpajassa alakouluikäiset oppilaat saivat tehtäväkseen koota pareittain jalkapallon geometrisen representaation 4DFrame-rakennussarjan muoviputkista ja -kiinnikkeistä. Tapaustutkimuksemme osoittaa, miten tämän kaltaisen ohjatun rakennustehtävän aikana katse,…

3 He/4He Signature of Magmatic Fluids from Telica (Nicaragua) and Baru (Panama) Volcanoes, Central American Volcanic Arc

2022

Constraining the magmatic 3He/4He signature of fluids degassed from a magmatic system is crucial for making inferences on its mantle source. This is especially important in arc volcanism, where variations in the composition of the wedge potentially induced by slab sediment fluids must be distinguished from the effects of magma differentiation, degassing, and crustal contamination. The study of fluid inclusions (FIs) trapped in minerals of volcanic rocks is becoming an increasingly used methodology in geochemical studies that integrates the classical study of volcanic and geothermal fluids. Here, we report on the first noble gas (He, Ne, Ar) concentrations and isotopic ratios of FI in olivin…

Desigualdades algorítmicas: conductas de alto riesgo para los derechos humanos

2022

Este artículo propone un análisis sobre las desigualdades originadas o reforzadas por el uso de los modelos y programas de aprendizaje automático que encuentran una de sus principales justificaciones en el principio de precisión predictiva, así como sobre algunas respuestas que cabe esperar del sistema jurídico para abordarlas. Este tema ha sido tratado fundamentalmente bien a través de la tutela del derecho a la privacidad y la protección de datos, bien mediante la elaboración de códigos éticos. Aquí se adoptarán dos perspectivas distintas a las anteriores. En primer lugar, el enfoque del riesgo, marco en el que se ha empla-zado recientemente la regulación europea de la inteligencia artifi…

Early and Longitudinal Humoral Response to the SARS-CoV-2 mRNA BNT162b2 Vaccine in Healthcare Workers: Significance of BMI, Adipose Tissue and Muscle…

2022

Background: This study aimed to investigate the early and longitudinal humoral response in Healthcare Workers (HCWs) after two doses of the BNT162b2 vaccine and to assess the association between metabolic and anthropometric parameters and the humoral response after vaccination. Methods: The study included 243 fully vaccinated HCWs: 25.50% previously infected with SARS-CoV-2 (with prior history of COVID-19—PH) and 74.40%—uninfected, seronegative before the first vaccination (with no prior history of COVID-19—NPH). IgG antibodies were measured, and sera were collected: prior to the vaccination, 21 days after the first dose, and 14 days and 8 months after the second dose. Res…

Enhancing Attention’s Explanation Using Interpretable Tsetlin Machine

2022

Explainability is one of the key factors in Natural Language Processing (NLP) specially for legal documents, medical diagnosis, and clinical text. Attention mechanism has been a popular choice for such explainability recently by estimating the relative importance of input units. Recent research has revealed, however, that such processes tend to misidentify irrelevant input units when explaining them. This is due to the fact that language representation layers are initialized by pre-trained word embedding that is not context-dependent. Such a lack of context-dependent knowledge in the initial layer makes it difficult for the model to concentrate on the important aspects of input. Usually, th…

Modular Service Design of Information Technology-Enabled Services

2022

The literature has proposed ways to modularize information-technology-enabled services (ITeS) with limited success. We argue that applying design principles (DPs) can address this gap and revitalize the service modularization literature. With a qualitative research study, we develop exemplar DPs and a set of prioritized DPs for ITeS. We contribute to the literature by demonstrating how complex service systems, specifically ITeS, can be modularly designed. Our DPs show how different ITeS design elements or service attribute combinations impact the outcome-driven design of service experience. Based on the findings, we present a modular service design framework and a service design method tha…

A Vaccine Construction against COVID-19-Associated Mucormycosis Contrived with Immunoinformatics-Based Scavenging of Potential Mucoralean Epitopes

2022

Mucormycosis is a group of infections, caused by multiple fungal species, which affect many human organs and is lethal in immunocompromised patients. During the COVID-19 pandemic, the current wave of mucormycosis is a challenge to medical professionals as its effects are multiplied because of the severity of COVID-19 infection. The variant of concern, Omicron, has been linked to fatal mucormycosis infections in the US and Asia. Consequently, current postdiagnostic treatments of mucormycosis have been rendered unsatisfactory. In this hour of need, a preinfection cure is needed that may prevent lethal infections in immunocompromised individuals. This study proposes a potential vaccine constru…

Process-based microphysical characterization of a strong mid-latitude convective system using aircraft in situ cloud measurements

2022

Clouds in the mixed-phase temperature regime impose a large uncertainty onto climate prediction models, in part due to incomplete knowledge of the degree of glaciation affecting cloud radiative properties. To achieve a better representation of these clouds, it is crucial to improve the understanding of ice nucleation and growth as well as microphysical properties determining the cloud phase. In this case study, we provide a rare data set of aircraft in situ measurements in a strong mid-latitude convective system extending from the boundary layer to the tropopause and aim to extend the sparse database of such measurements. Data were obtained with the research aircraft HALO and cloud properti…

Longitudinal Study on Sustained Attention to Response Task (SART): Clustering Approach for Mobility and Cognitive Decline

2022

The Sustained Attention to Response Task (SART) is a computer-based go/no-go task to measure neurocognitive function in older adults. However, simplified average features of this complex dataset lead to loss of primary information and fail to express associations between test performance and clinically meaningful outcomes. Here, we combine a novel method to visualise individual trial (raw) information obtained from the SART test in a large population-based study of ageing in Ireland and an automatic clustering technique. We employed a thresholding method, based on the individual trial number of mistakes, to identify poorer SART performances and a fuzzy clusters algorithm to partition the da…

Spinal epidural abscess due to acute pyelonephritis

2022

Background: Spinal epidural abscesses are rare and are misdiagnosed in up to 75% of cases. Fever, back pain, and neurological deficits are part of the classical triad. Here, the authors report a patient with a L2–L5 spinal epidural abscess with the left paravertebral extension attributed to acute pyelonephritis. Case Description: A 54-year-old female presented with persistent low back pain and lower extremity weakness accompanied by paresthesias. Previously, she had been hospitalized with the left acute pyelonephritis. The lumbosacral MRI documented a T12/L5 anterior epidural abscess with ring enhancement on the contrast study; the maximum diameter of the abscess at the L2–L3 level contrib…

Cultivable Fungal Endophytes in Roots, Rhizomes and Leaves of Posidonia oceanica (L.) Delile along the Coast of Sicily, Italy

2022

The presence of endophytic fungi in the roots, rhizomes, and leaves of Posidonia oceanica was evaluated in different localities of the Sicilian coast. Samples of roots, rhizomes, and leaves were submitted to isolation techniques, and the obtained fungal colonies were identified by morphological and molecular (rRNA sequencing) analysis. Fungal endophytes occurred mainly in roots and occasionally in rhizomes and leaves. Lulwoana sp. was the most frequent of the isolated taxa, suggesting a strong interaction with the host. In addition, eight other fungal taxa were isolated. In particular, fungi of the genus Ochroconis and family Xylariaceae were identified as endophytes in healthy plants at al…

La Caravella portoghese abita il Mediterraneo da sempre, anche se non lo sapevamo

2022

Ajan yhteismitattomuus Chris Watsonin ääniteoksessa The Green Rooms

2022

The determinants of FDI: a new network-based approach

2022

This article investigates the determinants of FDI at sub-national level. It recognizes that MNEsModified Letter Turned Comma foreign activities are organized in networks of strongly interconnected, but geographically dispersed affiliates. This implies a different approach to the analysis of the determinants of FDI, which should focus on contextual factors able to stimulate economic relations at distance. Methodologically, we use a gravity-type model and different regression techniques with a new dataset on networks of FDI involving German and Italian regions. We find evidence that technologically proximate regions sharing the same industry profile are more likely to experience positive and …