showing 36 of ~574560 from 574555 documents
Rethinking Monetary Policy in the Framework of Inclusive and Sustainable Growth
2021
The 2030 Agenda for Sustainable Development places equality and sustainability at the centre of policy agendas. Nowadays, socially inclusive and environmentally sustainable economic growth is a central priority of public policy for most governments worldwide. Based on the theoretical and conceptual frameworks of inclusive growth and sustainable growth, we focus on monetary policy as a powerful macroeconomic policy tool connected with distributional and environmental issues. We deal with how high levels in income and wealth inequality, on the one hand, and shocks related to environmental degradation and climate change, on the other hand, it might have substantial implications for the conduct…
Fishing and wine production, two waste types and one solution: antimicrobial activity of new food packaging.
2021
High-rate cycling performance of lead-acid batteries with nanostructured electrodes
2021
In this work we present lead-acid batteries with nanostructured electrodes cycled with different C-rate from 1C (1 hour to complete charge) up to 30C (120 seconds to complete charge) and imposing a very deep discharge. In comparison to the parameters usually used for commercial batteries, these are much more stressful conditions in terms of cut-off and charge/discharge rate.
An unusual case of cytoplasmic CD3 expressing BPDCN supporting the T‐lineage origin of plasmacytoid dendritic cells
2021
Bell e net vidre. Producción, distribución y consumo de vidrio en el reino de Valencia durante la Baja Edad Media
2021
El presente artículo analiza el desarrollo de la industria vidriera valenciana entre los siglos XIII y XV. Para ello se recurre a un centenar de documentos de carácter notarial, normativo, judicial y fiscal, procedentes de distintos archivos valencianos. Estos permiten estudiar la localización de los hornos de vidrio en el reino de Valencia y las formas de trabajo de los vidrieros, así como los procesos de distribución y los sistemas de venta del vidrio doméstico. Finalmente, se aborda la demanda y el consumo de estos bienes y sus usos en las viviendas de diferentes sectores sociales de la época. Todo ello invita a reconsiderar la relevancia de esta industria en el reino de Valencia, mucho …
Artificial selection for predatory behavior results in dietary niche differentiation in an omnivorous mammal
2021
AbstractThe diet of an individual is a result of the availability of dietary items and the individual’s foraging skills and preferences. Behavioral differences may thus influence diet variation, but the evolvability of diet choice through behavioral evolution has not been studied. We used experimental evolution combined with a field enclosure experiment to test whether behavioral selection leads to dietary divergence. We analysed the individual dietary niche via stable isotope ratios of nitrogen (δ15N) and carbon (δ13C) in the hair of an omnivorous mammal, bank vole, from 4 lines selected for predatory behavior and 4 unselected control lines. Predatory voles had higher hair δ15N values than…
Cyclic Analogs of Desferrioxamine E Siderophore for 68Ga Nuclear Imaging: Coordination Chemistry and Biological Activity in Staphylococcus aureus
2021
As multidrug-resistant bacteria are an emerging problem and threat to humanity, novel strategies for treatment and diagnostics are actively sought. We aim to utilize siderophores, iron-specific strong chelating agents produced by microbes, as gallium ion carriers for diagnosis, applying that Fe(III) can be successfully replaced by Ga(III) without losing biological properties of the investigated complex, which allows molecular imaging by positron emission tomography (PET). Here, we report synthesis, full solution chemistry, thermodynamic characterization, and the preliminary biological evaluation of biomimetic derivatives (FOX) of desferrioxamine E (FOXE) siderophore, radiolabeled with 68Ga …
Impact of gluconate and hexitol additives on the precipitation mechanism and kinetics of C-S-H
2021
The present paper investigates the influence of gluconate and hexitol additives on the precipitation mechanism and kinetics of C-S-H. To this end, wet chemistry C-S-H precipitation experiments were performed under controlled conditions of solution supersaturation, under varying silicate concentration, while the transmittance of the solution was followed. This allowed determining induction times for the formation of C-S-H precursors in the presence and absence of gluconate and three hexitol molecules. Characterization of the precipitates was performed via small angle X-ray scattering and cryo-transmission electron microscopy experiments, which allowed the identification of a multi-step nucle…
Reducing the Cost of Being the Boss: Authentic Leadership Suppresses the Effect of Role Stereotype Conflict on Antisocial Behaviors in Leaders and En…
2021
What drives entrepreneurs to engage in antisocial economic behaviors? Without dismissing entrepreneurs’ agency in their decision-making processes, our study aims to answer this question by proposing that antisocial economic behaviors are a dysfunctional coping mechanism to reduce the psychological tension that entrepreneurs face in their day-to-day activities. Further, given the overlap between the male gender role stereotype and both leader and entrepreneur role stereotypes, this psychological tension should be stronger in female entrepreneurs (or any person who identifies with the female gender role). We argue that besides the well-established female gender role – leader role incongruence…
What about Swedish?
2021
The chapter discusses discourses of “language” indexing social tasks of universities. We are interested in how talk of “language” is used to index the political, economic, educational, cultural etc. nature of higher education; in other words, what we talk about when we think we talk about language. We are mainly focusing on the position Swedish in the tensions of national language policies, higher education policies and internationalisation. In the chapter, we show the various ways in which higher education policies and language policies are intertwined, producing both intended and unintended language policy outcomes. peerReviewed
An Introduction to the HLanData Project: a Step Forward in the Harmonization of Spatial Information Throughout Europe
2021
Nowadays spatial information is becoming more and more accessible for various purposes due to local, national and European initiatives. This paper is addressed to one such initiative Hlandata, whose purpose is to make a significant step forward in the harmonization and use of land cover (LC) and land use (LU) geographic data and its related data bases over Europe. The project was developed using the best experiences from previous geographic data harmonization activities with the goal of demonstrating the feasibility of European level harmonization of land information related datasets. The three pilot projects “LU-LC Data Analysis System for intermediatelevel users”, “Harmonized and Interope…
CRISPR-Cas12a-Based Detection of SARS-CoV-2 Harboring the E484K Mutation
2021
The novel respiratory virus SARS-CoV-2 is rapidly evolving across the world with the potential of increasing its transmission and the induced disease. Here, we applied the CRISPR-Cas12a system to detect, without the need of sequencing, SARS-CoV-2 genomes harboring the E484K mutation, first identified in the Beta variant and catalogued as an escape mutation. The E484K mutation creates a canonical protospacer adjacent motif for Cas12a recognition in the resulting DNA amplicon, which was exploited to obtain a differential readout. We analyzed a series of fecal samples from hospitalized patients in Valencia (Spain), finding one infection with SARS-CoV-2 harboring the E484K mutation, which was t…
Gluconate and hexitols effects on C-S-H solubility
2021
This study investigates the effect of gluconate, a carboxylate ion, and three uncharged hexitols, D-sorbitol, D-mannitol and D-galactitol on the solubility of C-S-H. Thermodynamic modeling was used to determine the kind and amount of Ca-organic-silicate-OH complexes that potentially form in the conditions studied. All the organics form complexes with calcium and hydroxide, In addition, heteropolynuclear organics complexes with calcium, hydroxide and silicate are observed at high pH values and high calcium concentrations with the exception of mannitol. The strength of complexation with silicate decreases from gluconate > sorbitol > galactitol. The adsorption of the selected organics on…
Latvijas Universitātes vēsturiskais studentu karceris
2021
The University of Latvia has 19 th-century historical witness regarding the daily life of students during studies - the historical student solitary confinement cell. The origins of the student solitary confinement cell are found in medieval Germany, when universities were entitled to detain students into cells for the misdeeds during the studies. The idea was realized in the 19th century, which coincided with the time when German academic influence spread in the Baltics. During the occupation of the USSR, this history phenomenon was forgotten or distorted, but it is now rehabilitated. The Museum of the University of Latvia with the University of Latvia Academic Press has issued booklet, whi…
Subsynaptic Distribution, Lipid Raft Targeting and G Protein-Dependent Signalling of the Type 1 Cannabinoid Receptor in Synaptosomes from the Mouse H…
2021
Numerous studies have investigated the roles of the type 1 cannabinoid receptor (CB1) in glutamatergic and GABAergic neurons. Here, we used the cell-type-specific CB1 rescue model in mice to gain insight into the organizational principles of plasma membrane targeting and Gαi/o protein signalling of the CB1 receptor at excitatory and inhibitory terminals of the frontal cortex and hippocampus. By applying biochemical fractionation techniques and Western blot analyses to synaptosomal membranes, we explored the subsynaptic distribution (pre-, post-, and extra-synaptic) and CB1 receptor compartmentalization into lipid and non-lipid raft plasma membrane microdomains and the signalling properties.…
N‐Terminal Modification of Gly‐His‐Tagged Proteins with Azidogluconolactone
2021
Site-specific protein modifications are vital for biopharmaceutical drug development. Gluconoylation is a non-enzymatic, post-translational modification of N-terminal HisTags. We report high-yield, site-selective inâ vitro α-aminoacylation of peptides, glycoproteins, antibodies, and virus-like particles (VLPs) with azidogluconolactone at pHâ 7.5 in 1â h. Conjugates slowly hydrolyse, but diol-masking with borate esters inhibits reversibility. In an example, we multimerise azidogluconoylated SARS-CoV-2 receptor-binding domain (RBD) onto VLPs via click-chemistry, to give a COVID-19 vaccine. Compared to yeast antigen, HEK-derived RBD was immunologically superior, likely due to observed diffe…
Expressions of “fast” and “slow” chameleon dressed states in Autler–Townes spectra of alkali‐metal atoms
2021
Transient Focal Neurological Events in Cerebral Amyloid Angiopathy and the Long-term Risk of Intracerebral Hemorrhage and Death: A Systematic Review …
2021
Importance Transient focal neurological episodes (TFNEs) are a frequently overlooked presentation of cerebral amyloid angiopathy (CAA), a condition with prognostic implications that are still not well described. Objective To perform a systematic review and meta-analysis to examine the factors associated with incident lobar intracerebral hemorrhage (ICH) and death in patients with CAA presenting with TFNEs. Data Sources A systematic review and individual participant meta-analysis including (1) a hospital-based cohort and (2) the results obtained from a systematic search performed in MEDLINE and Embase completed in December 2019. Study Selection Included studies were observational reports of …
Epidemiology and Pattern of Resistance of Gram-Negative Bacteria Isolated from Blood Samples in Hospitalized Patients: A Single Center Retrospective …
2021
Background: Blood culturing remains the mainstream tool to inform an appropriate treatment in hospital-acquired bloodstream infections and to diagnose any bacteremia. Methods: A retrospective investigation on the prevalence of Gram-negative bacteria (GNB) and their resistance in hospitalized patients by age, sex, and units from blood cultures (BCs) was conducted from January 2018 to April 2020 at Sant’Elia hospital, Caltanissetta, southern Italy. We divided the patient age range into four equal intervals. Results: Multivariate demographic and microbiological variables did not show an association between bacteria distributions and gender and age. The distribution by units showed a higher pre…
Der historische Studentenkarzer der Universität Lettlands
2021
Die Universität Lettlands beherbergt das historische Studentenkarzer, ein Zeugnis des täglichen Lebens der Studenten während ihres Studiums aus dem 19. Jahrhundert. Der Studentenkarzer geht auf das mittelalterliche Deutschland zurück, als die Universitäten das Recht hatten, Studenten für Vergehen während des Studiums in Zellen einzusperren. Die Idee wurde im 19. Jahrhundert mit der Ausbreitung des deutschen akademischen Einflusses im Baltikum verwirklicht. Dieses historische Phänomen geriet während der sowjetischen Besatzung in Vergessenheit oder wurde verfälscht, ist aber nun rehabilitiert worden. Das Museum der Universität Lettlands und der Akademische Verlag der Universität Lettlands hab…
The alien vascular flora of Stromboli and Vulcano (Aeolian Islands, Italy)
2021
The updated censuses of the alien flora of the islands of Stromboli and Vulcano, Aeolian Islands in the Central Tyrrhenian Sea, are presented here. They currently consist of 40 and 57 specific and subspecific taxa respectively. As many as 16 and 18 taxa respectively are new in comparison with the last censuses in 2016. Mesembryanthemum × vascosilvae, commonly cultivated in both islands, is reported for the first time as naturalized alien to Italy. Passiflora incarnata from Stromboli and Pelargonium graveolens from Vulcano are reported for the first time as casual aliens to Sicily. The evolution over time of these florulas, as inferred from the main floristic works published on these islands…
Membrane Structure of Aquaporin Observed with Combined Experimental and Theoretical Sum Frequency Generation Spectroscopy
2021
High-resolution structural information on membrane proteins is essential for understanding cell biology and for the structure-based design of new medical drugs and drug delivery strategies. X-ray diffraction (XRD) can provide angstrom-level information about the structure of membrane proteins, yet for XRD experiments, proteins are removed from their native membrane environment, chemically stabilized, and crystallized, all of which can compromise the conformation. Here, we describe how a combination of surface-sensitive vibrational spectroscopy and molecular dynamics simulations can account for the native membrane environment. We observe the structure of a glycerol facilitator channel (GlpF)…
Staying Active under Restrictions: Changes in Type of Physical Exercise during the Initial COVID-19 Lockdown
2021
Copyright: © 2021 by the authors. The COVID-19 pandemic and the associated governmental restrictions suddenly changed everyday life and potentially affected exercise behavior. The aim of this study was to explore whether individuals changed their preference for certain types of physical exercise during the pandemic and to identify risk factors for inactivity. An international online survey with 13,881 adult participants from 18 countries/regions was conducted during the initial COVID-19 related lock-down (between April and May 2020). Data on types of exercise performed during and before the initial COVID-19 lockdown were collected, translated, and categorized (free-text input). Sankey chart…
Historical University of Latvia student solitary confinement cell
2021
The University of Latvia has 19th-century historical witness regarding the daily life of students during studies - the historical student solitary confinement cell. The origins of the student solitary confinement cell are found in medieval Germany, when universities were entitled to detain students into cells for the misdeeds during the studies. The idea was realized in the 19th century, which coincided with the time when German academic influence spread in the Baltics. During the occupation of the USSR, this history phenomenon was forgotten or distorted, but it is now rehabilitated. The Museum of the University of Latvia with the University of Latvia Academic Press has issued booklet, whic…
false
2021
Because of its parasitic habits, reproduction costs of the common cuckoo (Cuculus canorus) are mostly spent in pre-laying activities. Female costs are limited to searching host nests and laying eggs, whereas, males spend time in performing intense vocal displays, possibly with territorial purpose. This last aspect, together with a sexual plumage dimorphism, points to both intra- and inter-sexual selections operating within this species. One element triggering sexual selection is a differential fitness accrued by different phenotypes. Before analyzing possible sexual selection mechanisms operating in cuckoos, it is therefore necessary to verify whether there is a variability among male secon…
Historical University of Latvia student solitary confinement cell: video
2021
The University of Latvia has 19th-century historical witness regarding the daily life of students during studies - the historical student solitary confinement cell. The origins of the student solitary confinement cell are found in medieval Germany, when universities were entitled to turn students into cells for the misdeeds during the studies. The idea was realized in the 19th century, which coincided with the time when German academic influence spread in the Baltics. During the occupation of the USSR, this history phenomenon was forgotten or distorted, but it is now rehabilitated. The Museum of the University of Latvia has filmed a video with subtitles in English about the student solitary…
Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators
2021
Both the initiation and the resolution of inflammatory responses are governed by the sequential activation, migration, and control/suppression of immune cells at the site of injury. Bioactive lipids play a major role in the fine-tuning of this dynamic process in a timely manner. During inflammation and its resolution, polymorphonuclear cells (PMNs) and macrophages switch from producing pro-inflammatory prostaglandins and leukotrienes to specialized pro-resolving lipid mediators (SPMs), namely, lipoxins, resolvins, protectins, and maresins, which are operative at the local level to limit further inflammation and tissue injury and restore homeostasis. Accumulating evidences expand now the rol…
Reverse transcriptase loop-mediated isothermal amplification (RT-LAMP) as a user-friendly system to detect SARS-CoV-2 infection: a multicentric study
2021
Although reverse transcriptase quantitative PCR remains the gold standard to perform viral detection, reverse transcriptase loop-mediated isothermal amplification (RT-LAMP) is already used to perform diagnosis of various infections. This work reports the results of a multicentric study performed in Sicily to evaluate the diagnostic power of an RT-LAMP kit for the diagnosis of SARS-CoV-2 infection on a total of 551 samples collected in January and February 2021, revealing sensitivity, specificity, accuracy, positive and negative predictive values ≥95%. Our results suggest the potential employment of this kit as a screening test to be used where fast and reliable results are demanded without …
Can QCD Axion Stars explain Subaru HSC microlensing?
2021
A non-negligible fraction of the QCD axion dark matter may form gravitationally bound Bose Einstein condensates, which are commonly known as axion stars or axion clumps. Such astrophysical objects have been recently proposed as the cause for the single candidate event reported by Subaru Hyper Suprime-Cam (HSC) microlensing search in the Andromeda galaxy. Depending on the breaking scale of the Peccei-Quinn symmetry and the details of the dark matter scenario, QCD axion clumps may form via gravitational condensation during radiation domination, in the dense core of axion miniclusters, or within axion minihalos around primordial black holes. We analyze all these scenarios and conclude that the…
The metric-valued Lebesgue differentiation theorem in measure spaces and its applications
2021
We prove a version of the Lebesgue Differentiation Theorem for mappings that are defined on a measure space and take values into a metric space, with respect to the differentiation basis induced by a von Neumann lifting. As a consequence, we obtain a lifting theorem for the space of sections of a measurable Banach bundle and a disintegration theorem for vector measures whose target is a Banach space with the Radon-Nikod\'{y}m property.
Respiratory Syncytial Virus: New Challenges for Molecular Epidemiology Surveillance and Vaccination Strategy in Patients with ILI/SARI.
2021
Several respiratory pathogens are responsible for influenza-like illness (ILI) and severe respiratory infections (SARI), among which human respiratory syncytial virus (hRSV) represents one of the most common aetiologies. We analysed the hRSV prevalence among subjects with ILI or SARI during the five influenza seasons before the emergence of SARS-CoV-2 epidemic in Sicily (Italy). Respiratory specimens from ILI outpatients and SARI inpatients were collected in the framework of the Italian Network for the Influenza Surveillance and molecularly tested for hRSV-A and hRSV-B. Overall, 8.1% of patients resulted positive for hRSV. Prevalence peaked in the age-groups <
The Sicilian rock partridge: latest data on genetic integrity from four different relict areas
2021
Sicily (Italy) hosts a “relict”, endemic population of the birds Alectoris graeca whitakeri commonly known as Sicilian Rock Partridge. In the last decades, due to the risk of restocking with other European and Asiatic species for hunting purpose, a study was carried out to investigate the potential risk of hybridisation. The mtDNA control-region and nuclear microsatellites were genotyped. Due to the importance of the species, samples were mainly characterized by feather and stool samples, and rarely by carcasses found in the environment, from year 2011 to 2012. A panel of 7 microsatellite loci was validated. Three multiplexes that allowed the simultaneous amplification of 3 microsatellites,…
The long history of rich fens supports persistence of plant and snail habitat specialists
2021
Increasing evidence for the effects of Holocene history on modern biotic communities suggests that current explanations of community patterns and conservation strategies require revisiting. Here we focused on Central European rich fens that are at high risk among mire habitats because of their relatively low environmental stability, and hence sensitivity to successional shifts. At each of 57 study sites, inventory of specialist species of bryophytes, vascular plants and land snails, measurements of local environmental conditions, area, and radiocarbon dating were conducted. We used Moran’s I spatial autocorrelation, multiple linear regression models, MDS, db-RDA, and null models to identify…
Defining minimum runoff length allows for discriminating biocrusts and rainfall events
2021
This study was started in the context of the research projects PECOS (REN2003-04570/GLO) and PREVEA (CGL2007-63258/BOS) , both funded by the Spanish National Plan for RD&I and by the European ERDF Funds (European Regional Development Fund) , and continued during the project SCIN (Soil Crust In-terNational, PRI-PIMBDV-2011-0874, European project of ERA-NET BIODIVERSA, the Spanish team being funded by the Spanish Ministry of Economy and Competitiveness) . The work was finally supported and culminated by the DINCOS project (CGL2016-78075-P, Spanish State Programme for Scientific Research) and by the European ERDF Funds (Euro-pean Regional Development Fund) . Consuelo Rubio's partici-pation was…
Microesferas de ácido poliláctico marcadas con 166Ho. Una alternativa frente a las de 90Y en el tratamiento del carcinoma hepático mediante radioembo…
2021
Los tumores hepáticos constituyen un importante problema de salud a nivel mundial que en multitud de ocasiones va asociado a patologías previas y factores de riesgo como las hepatitis víricas B y C, el consumo excesivo de alcohol y el aumento de casos de esteatohepatitis no alcohólica, cada vez más relevante en los países industrializados.En hepatocarcinomas no susceptibles de resección quirúrgica, la braquiterapia se está mostrando muy eficaz frente a la quimioterapia sistémica y transarterial, por lo que se desarrollan nuevos tratamientos locorregionales mínimamente invasivos y con menor toxicidad.La radioembolización hepática es una forma de braquiterapia consistente en la administración…
Experimental evidence of high spatial confinement of elastic energy in a phononic cantilever
2021
We report on experimental high spatial confinement of elastic energy in a silicon phononic cantilever for which the quality factor of a higher-order flexural resonance is increased by a factor of 27 (from Q ∼ 80 to Q ∼ 2130) with the use of a three-row phononic crystal (PnC) strip. As shown by numerical simulations performed with the finite element method, the PnC both reduces anchor loss and confines elastic energy inside the cantilever. The PnC and the cantilever are fabricated with standard clean room techniques on a silicon on insulator substrate. Optical measurements of the out-of-plane displacements are performed with a laser scanning interferometer in a frequency range around 2 MHz.