showing 36 of ~574560 from 574555 documents
L'exequatur d'une sentence arbitrale à seule fin de sa reconnaissance et de son opposabilité
2021
International audience; (Com. 12 nov. 2020, n° 19-18.849, Sté IPSA Holding, sté CBF associés et sté Brouard-Chaudé c/ Sté Alpha Pétrovision Holding AG, D. 2020. 2286 ; ibid. 2484, obs. T. Clay ; ibid. 2021. 1736, obs. F.-X. Lucas et P. Cagnoli ; RTD civ. 2021. 486, obs. N. Cayrol ; RTD com. 2021. 192, obs. A. Martin-Serf ; Rev. arb. 2021. 236, note D. Bureau)
Sustainable Development Model of EU Cities Compliant with UN Settings
2021
Nowadays, the globally accepted UN concept of sustainable development (SD) is gradu®ally transferred to the city level, including small and medium-sized cities. The implementation of SD settings requires regular measurement of developmental progress to monitor the level achieved in statics and dynamics, and to make strategic decisions for the next period. The existing urban SD indicator systems and indices are not well-suited for the monitoring of specific cities. Benchmarking algorithms and mathematical modelling procedures were applied to create a methodology and mathematical model for measuring the achieved urban SD level and to ensure the most objective selection and proportions of key …
L'Ecomusée de la Bresse bourguignonne habite-t-il son territoire?
2021
International audience
Simurgh
2021
The availability of non-volatile main memory (NVMM) has started a new era for storage systems and NVMM specific file systems can support extremely high data and metadata rates, which are required by many HPC and data-intensive applications. Scaling metadata performance within NVMM file systems is nevertheless often restricted by the Linux kernel storage stack, while simply moving metadata management to the user space can compromise security or flexibility. This paper introduces Simurgh, a hardware-assisted user space file system with decentralized metadata management that allows secure metadata updates from within user space. Simurgh guarantees consistency, durability, and ordering of updat…
On the Shape-Selected, Ligand-Free Preparation of Hybrid Perovskite (CH3NH3PbBr3) Microcrystals and Their Suitability as Model-System for Single-Crys…
2021
Hybrid perovskite materials are one of the most promising candidates for optoelectronic applications, e.g., solar cells and LEDs, which can be produced at low cost compared to established materials. Although this field of research has seen a huge upsurge in the past decade, there is a major lack in understanding the underlying processes, such as shape-property relationships and the role of defects. Our aerosol-assisted synthesis pathway offers the possibility to obtain methylammonium lead bromide (MAPbBr3 ) microcrystals from a liquid single source precursor. The differently shaped particles are aligned on several substrates, without using a directing agent or other additives. The obtained …
Faut-il soumettre aux mêmes règles l'arbitrage interne étranger et l'arbitrage international ?
2021
International audience; (Civ. 1re, 13 janv. 2021, n° 19-22.932, F-P+I, Sté Egyptian General Petroleum Corporation (EGPC) c/ Société National Gas Company (NATGAS), D. 2021. 86)
La création d'un droit spécifique de l'arbitrage international des litiges de la consommation
2021
International audience; (Civ. 1re, 30 sept. 2020, n° M 18-19.241 (FS-P+B), Sté PWC Landwell / MA. Lefebvre et autres, D. actu. 19 oct. 2020, note J. Jourdan-Marqués, 1949 ; D. 2020. 2501, note D. Mouralis ; ibid. 2484, obs. T. Clay ; ibid. 2021. 594, obs. H. Aubry, E. Poillot et N. Sauphanor-Brouillaud ; ibid. 923, obs. S. Clavel et F. Jault-Seseke ; AJ contrat 2020. 485, obs. D. Mainguy ; Rev. prat. rec. 2021. 39, chron. R. Bouniol ; Rev. crit. DIP 2021. 202, note E. Loquin ; RTD civ. 2020. 845, obs. L. Usunier ; JCP 2020. 311, note M. de Fontmichel ; JDI 2020. 1307, note E. Gaillard)
L'arbitre n'engage pas sa responsabilité en méconnaissant le principe du contradictoire
2021
International audience; (Paris 21 mai 2019, Blow Pack SARL c/ M. C. et a., Rev. arb. 2020. 794, note L. Jandar)
A novel compound heterozygous mutation in GALC associated with adult-onset Krabbe disease: case report and literature review
2021
Krabbe disease (KD) is a rare autosomal recessive lipid storage leukodystrophy. It is caused by deficient enzyme activity resulting from mutations of the β-galactocerebrosidase (GALC) gene. KD is distinguished into subtypes based on the age of onset; these are early infantile, late infantile, juvenile, and adult-onset. We report a case of a 47-year-old Caucasian man with a 2-year history of muscle atrophy and weakness in both hands associated with pyramidal signs and mild spasticity in the lower limbs. An extensive work-up led this motor neuron disease-like disorder to be diagnosed as adult-onset KD. The patient was found to be compound heterozygous for two GALC mutations (p.G286D and p.Y49…
Nullité de droit. Paiement par compensation d'une dette non échue provoqué par le jeu d'un avenant mettant un terme prématuré au contrat
2021
International audience; (Com. 20 janv. 2021, n° 19-15.108, arrêt n° 47 F-D, Sté Friedland c/ Mme B., ès qual.)
Caution. Recours contre un cofidéjusseur après la clôture de la liquidation judiciaire pour insuffisance d'actif
2021
International audience; (Com. 5 mai 2021, n° 20-14.672, arrêt n° 371 F-P, Sté Compagnie européenne de garanties et cautions c/ M. X., D. 2021. 901 ; Rev. sociétés 2021. 406, obs. L. C. Henry)
Arrêt des poursuites individuelles. Conditions de la reprise d'une instance interrompue
2021
International audience; (Com. 3 févr. 2021, n° 19-19.010, arrêt n° 97 F-D, GAEC des Linières et a. c/ Sté Aliteams, Gaz. Pal. 13 avr. 2021, p. 69, note K. Lafaurie)
Déclaration et vérification des créances. Différence entre l'irrecevabilité de la demande de fixation d'une créance et le rejet de la créance entraîn…
2021
International audience; (Com. 10 mars 2021, n° 19-22.395, arrêt n° 277-FS-P, M.W. Y. et a. c/ Fonds commun de titrisation Hugo créances II, D. 2021. 572 ; ibid. 993, chron. S. Barbot, C. de Cabarrus, S. Kass-Danno et A.-C. Le Bras ; RJDA 2021, n° 411)
Crédit-bail. Demande de restitution par le crédit-preneur contre le crédit-bailleur exerçant un droit de rétention
2021
International audience; (Com. 17 févr. 2021, n° 19-11.132, arrêt n° 169 F-P, Sté BPCE Lease banque populaire Alsace Lorraine Champagne c/ Sté Centrale solaire des terres rouges, D. 2021. 1015, note C. Juillet)
Déclaration et vérification des créances. Différence entre l'irrégularité de la déclaration et le rejet de la créance entraînant son extinction
2021
International audience; (Com. 5 mai 2021, n° 19-17.736, arrêt n° 447 FS- P, M.Z. et a. c/ Sté Lyonnaise de banque, D. 2021. 901 ; Rev. sociétés 2021. 404, obs. F. Reille)
L'application des principes Unidroit par le tribunal arbitral
2021
International audience; (Paris, pôle 1, ch. 1, 25 févr. 2020, Sté Prakash Steellage Ltd c/Sté Uzuc SA, Rev. arb. 2020. 208, note D. Bureau)
Caution personne physique. Possibilité de se prévaloir du plan de sauvegarde. Droit transitoire
2021
International audience; (Com. 10 mars 2021, nos 19-16.816 et 19-17.154, arrêt n° 213 F-P, Sté Nord voile et a. c/ Sté Intrum Justitia Debt Finance AG et a., D. 2021. 572 ; Rev. prat. rec. 2021. 25, chron. P. Roussel Galle et F. Reille ; RTD com. 2021. 437, obs. H. Poujade ; RJDA 2021, n° 415)
Enforced monoandry over generations induces a reduction of female investment into reproduction in a promiscuous bird.
2021
Abstract While uncovering the costs and benefits of polyandry has attracted considerable attention, assessing the net effect of sexual selection on population fitness requires the experimental manipulation of female mating over generations, which is usually only achievable in laboratory populations of arthropods. However, knowing if sexual selection improves or impairs the expression of life‐history traits is key for the management of captive populations of endangered species, which are mostly long‐lived birds and mammals. It might therefore be questionable to extrapolate the results gathered on laboratory populations of insects to infer the net effect of sexual selection on populations of …
The Potential Role of miRNAs in Cognitive Frailty.
2021
Frailty is an aging related condition, which has been defined as a state of enhanced vulnerability to stressors, leading to a limited capacity to meet homeostatic demands. Cognitive impairment is also frequent in older people, often accompanying frailty. Age is the main independent risk factor for both frailty and cognitive impairment, and compelling evidence suggests that similar age-associated mechanisms could underlie both clinical conditions. Accordingly, it has been suggested that frailty and cognitive impairment share common pathways, and some authors proposed “cognitive frailty” as a single complex phenotype. Nevertheless, so far, no clear common underlying pathways have been discove…
New Tools for Streamlined In Vivo Homing Peptide Identification
2021
In vivo peptide-phage display is an unbiased technique for mapping of the vascular diversity and identification of homing peptides. This chapter is intended to serve as a structured practical guide to execute in vivo T7 phage biopanning and data analysis experiments. We discuss experimental designs and protocols with emphasis on application of high-throughput sequencing-based technologies for streamlined in vivo biopanning and validation of homing peptides.
Health risks of Simulium (Boophthora) erythrocephalum (De Geer, 1776) in the Valencian Autonomous Region, Eastern Spain
2021
The presence and distribution of Simulium erythrocephalum (De Geer, 1776) in the Valencian Autonomous Region is analyzed, an arthropod of medical-sanitary importance due to the marked anthropophilic characteristics exhibited and the tendency to carry out massive attacks. The increasing incidence registered in certain areas as a consequence of their hematophagy, and the meager availability of epidemiological, fauna, bioecological, and distribution data, have led to this study. A field study of 137 samplings was carried out from 2013 to the present in the 14 hydrographic basins of the Valencian Autonomous Region. The study variables were the presence or absence of preimaginal states, environm…
Accuracy and Safety of Ultrasound-Guided Core Needle Biopsy of Soft Tissue Tumors in an Outpatient Setting: A Sarcoma Center Analysis of 392 Consecut…
2021
Simple Summary In patients with unclear soft tissue lesions, treatment planning largely depends on histology. Core needle biopsy is the diagnostic standard in these cases. The aim of this retrospective study was to investigate accuracy and safety of ultrasound guided core needle biopsy at a tertiary referral center. We show that ultrasound guided biopsy was feasible as a one stop shop procedure in an outpatient setting in 87.6% of the cases. The rate of conclusive biopsies was 88.5%. After surgical resection, the dignity, tumor type and histopathological grading of the biopsy matched one of the resection specimens in 97.2%, 92.7% and 92.5% of the cases, respectively. Major complications occ…
Inhibition of TSH/IGF-1 Receptor Crosstalk by Teprotumumab as a Treatment Modality of Thyroid Eye Disease
2021
Abstract Context We previously presented evidence that TSH receptor (TSHR)-stimulating autoantibodies (TSAbs) bind to and activate TSHRs but do not bind to IGF1 receptors (IGF1Rs). Nevertheless, we showed that IGF1Rs were involved in thyroid eye disease (TED) pathogenesis because TSAbs activated crosstalk between TSHR and IGF1R. Teprotumumab, originally generated to inhibit IGF1 binding to IGF1R, was recently approved for the treatment of TED (Tepezza). Objective To investigate the role of TSHR/IGF1R crosstalk in teprotumumab treatment of TED. Design We used orbital fibroblasts from patients with TED (TEDOFs) and measured stimulated hyaluronan (HA) secretion as a measure of orbital fibrobla…
Valorization of kiwi agricultural waste and industry by-products by recovering bioactive compounds and applications as food additives : a circular ec…
2021
Currently, agricultural production generates large amounts of organic waste, both from the maintenance of farms and crops (agricultural wastes) and from the industrialization of the product (food industry waste). In the case of Actinidia cultivation, agricultural waste groups together leaves, flowers, stems and roots while food industry by-products are represented by discarded fruits, skin and seeds. All these matrices are now underexploited and so, they can be revalued as a natural source of ingredients to be applied in food, cosmetic or pharmaceutical industries. Kiwifruit composition (phenolic compounds, volatile compounds, vitamins, minerals, dietary fiber, etc.) is an outstanding basis…
Using Tsetlin Machine to discover interpretable rules in natural language processing applications
2021
Tsetlin Machines (TM) use finite state machines for learning and propositional logic to represent patterns. The resulting pattern recognition approach captures information in the form of conjunctive clauses, thus facilitating human interpretation. In this work, we propose a TM-based approach to three common natural language processing (NLP) tasks, namely, sentiment analysis, semantic relation categorization and identifying entities in multi-turn dialogues. By performing frequent itemset mining on the TM-produced patterns, we show that we can obtain a global and a local interpretation of the learning, one that mimics existing rule-sets or lexicons. Further, we also establish that our TM base…
BIOM-08. DNA METHYLATION-BASED SUBGROUPING PREDICTS SURVIVAL BENEFIT FROM LOMUSTINE/TEMOZOLOMID COMBINATION THERAPY IN MGMT PROMOTOR-METHYLATED GLIOB…
2021
Abstract BACKGROUND The CeTeG/NOA-09 trial showed that lomustine/temozolomide chemotherapy prolongs survival for newly diagnosed MGMT-methylated glioblastoma patients. Previous reports on temozolomide monotherapy suggested, that the survival benefit of temozolomide in MGMT-methylated tumors may be restricted to the RTK II methylation subgroup and absent in RTK I and MES subgroups. To identify patients with a particularly strong benefit from CCNU/TMZ, we explored the association of methylation subgroups with outcome after lomustine/temozolomide therapy. METHODS All patients from the CeTeG/NOA-09 trial with sufficiently available tumor tissue (n = 98) underwent 850K methylation array analysis…
A new look at the meeting clustering effect
2021
PurposeThe study aims to test the existence of a meeting clustering effect in the Spanish Stock Exchange (SSE).Design/methodology/approachThis paper studies the relationship between the clustering of annual general meetings and stock returns in the SSE. A multivariate analysis is carried out in order to analyse the relationship between monthly returns and the clustering of general meetings in the SSE.FindingsThe authors show that meeting clustering exists and that some months exhibit significant and positive additional returns related to the holding of ordinary or extraordinary general meetings.Research limitations/implicationsThe authors have explored some possible explanations for the mee…
Impact of Starmerella bacillaris and Zygosaccharomyces bailii on ethanol reduction and Saccharomyces cerevisiae metabolism during mixed wine fermenta…
2021
AbstractThe bulk of grape juice fermentation is carried out by the yeast Saccharomyces cerevisiae, but non-Saccharomyces yeasts can modulate many sensorial aspects of the final products in ways not well understood. In this study, some of such non-conventional yeasts were screened as mixed starter cultures in a fermentation defined medium in both simultaneous and sequential inoculations. One strain of Starmerella bacillaris and another of Zygosaccharomyces bailii were chosen by their distinct phenotypic footprint and their ability to reduce ethanol levels at the end of fermentation, particularly during simultaneous vinification. S. bacillaris losses viability strongly at the end of mixed fer…
Spelling in Finnish : the case of the double consonant
2021
Because of its regularity, it is relatively easy to learn to read and spell in Finnish. However, a specific hurdle in spelling acquisition seems to be the doubling of consonant letters. In this study on consonant letter doubling spelling in Finnish children (91 Grade 1 and 191 Grade 2 children), we asked two questions. First, are items with double consonant letters (e.g., “kissa” [ˈkisːɑ] ‘cat’) indeed harder to spell than single consonant items (e.g., “kisa” [ˈkisɑ] ‘contest’)? Second, is consonant doubling harder for stop consonants (e.g., “takki” [ˈtɑkːi] ‘coat’) than for continuant consonants (e.g., “kissa&rdq…
Morphological Alterations and Stress Protein Variations in Lung Biopsies Obtained from Autopsies of COVID-19 Subjects
2021
Molecular chaperones, many of which are heat shock proteins, play a role in cell stress response and regulate the immune system in various ways, such as in inflammatory/autoimmune reactions. It would be interesting to study the involvement of these molecules in the damage done to COVID-19-infected lungs. In our study, we performed a histological analysis and an immunomorphological evaluation on lung samples from subjects who succumbed to COVID-19 and subjects who died from other causes. We also assessed Hsp60 and Hsp90 distribution in lung samples to determine their location and post-translational modifications. We found histological alterations that could be considered pathognomonic for CO…
Preliminary geochemical characterization of the Mts. Simbruini karst aquifer (Central Italy)
2021
Mts. Simbruini karst aquifer feeds important springs whose capture contributes to the water supply of Rome City. To improve the geochemical characterization of this aquifer, we analyzed 36 groundwater samples, 29 from springs and 7 from shallow wells, collected in 1996 and 2019. Atomic adsorption spectroscopy, tritration, ionic chromatography and mass spectrometry were the used analytical methods. Ground waters are bicarbonate alkaline-earth type and HCO3 dominance confirms that the aquifer is hosted in carbonate rocks. Total alkalinity vs. cations plot indicates that CO2 driven weathering controls the water chemistry. The probability plots of HCO3, cations and Ca2+ +Mg2+ indicate four grou…
Modelling the spatial and temporal constrains of the GABAergic influence on neuronal excitability
2021
GABA (γ-amino butyric acid) is an inhibitory neurotransmitter in the adult brain that can mediate depolarizing responses during development or after neuropathological insults. Under which conditions GABAergic membrane depolarizations are sufficient to impose excitatory effects is hard to predict, as shunting inhibition and GABAergic effects on spatiotemporal filtering of excitatory inputs must be considered. To evaluate at which reversal potential a net excitatory effect was imposed by GABA (EGABAThr), we performed a detailed in-silico study using simple neuronal topologies and distinct spatiotemporal relations between GABAergic and glutamatergic inputs. These simulations revealed for GABAe…
El ocaso del primer imperio mexicano. Agitación política y planes monárquicos en 1823
2021
La abdicación de Agustín de Iturbide al trono de México en 1823 y su posterior exilio desataron tensiones políticas que radicalizaron las posiciones ideológicas de quienes deseaban su regreso. La movilización popular simpatizante de la monarquía y la ruptura federalista en las provincias provocaron una crisis política e incertidumbre sobre el futuro del país. La inestabilidad e indefinición de la situación política en ese año propiciaron conspiraciones a favor del imperio. Este trabajo pretende acercarse a algunos de esos planes conspirativos dirigidos a mantener viva la opción monárquica desde las posiciones moderadas hasta las menos conocidas, pero plenamente ultramontanas. Para ello se e…
false
2021
The present study aimed to examine effects of motivational and social cognition constructs on children’s leisure-time physical activity participation alongside constructs representing implicit processes using an extended trans-contextual model. The study adopted a correlational prospective design. Secondary-school students (N = 502) completed self-report measures of perceived autonomy support from physical education (PE) teachers, autonomous motivation in PE and leisure-time contexts, and social cognition constructs (attitudes, subjective norms, perceived behavioral control), intentions, trait self-control, habits, and past behavior in a leisure-time physical activity context. Five weeks la…
Physical activity and health: Findings from Finnish monozygotic twin pairs discordant for physical activity
2021
AbstractGenetic and early environmental differences including early health habits associate with future health. To provide insight on the causal nature of these associations, monozygotic (MZ) twin pairs discordant for health habits provide an interesting natural experiment. Twin pairs discordant for leisure-time physical activity (LTPA) in early adult life are thus a powerful study design to investigate the associations between long-term LTPA and indicators of health and wellbeing. We have used this study design by identifying 17 LTPA discordant twin pairs from two Finnish twin cohorts and summarize key findings of these studies in this paper. The carefully characterized rare long-term LTPA…
The Role of Vitamin D in Early Knee Osteoarthritis and Its Relationship with Their Physical and Psychological Status
2021
Osteoarthritis (OA) is a common joint condition and one of the greatest causes of disability worldwide. The role of vitamin D in the origin and development of the disease is not clear, although it could have important implications for diagnosis and treatment. For this proposal, a cross-sectional study with a non-probabilistic sample was performed. In total, 48 with early osteoarthritis (EOA) and 48 matched controls were selected, and serum 25(OH)D and parathyroid hormone (PTH) levels were analyzed. In addition, physical and psychological variables were measured to establish their relationship with vitamin D levels. Patients with EOA showed lower levels (22.3 ± 7.3 ng/mL) in comparison to ma…