showing 36 of ~574560 from 574555 documents
Evaluating the effect of mineralogy and mechanical stability of recycled excavation materials by Los Angeles and micro-Deval test
2021
This paper presents the findings of the mechanical performance of recycled excavation materials (REM). The aim was to document the stable performance of REM and to suggest its suitability for unbound applications. Test operations were performed at different schedules with the Los Angeles (LA) and micro-Deval (MD) test machine. X-ray diffraction (XRD) analysis was performed to examine the effect of mineralogy on the performance of REM. The results showed that REM showed consistent LA performance, but significant variations were observed in MD values. XRD results showed that up to 20% of chlorite and mica minerals had no influence on the LA performance of REM.
Rationale and design of the Dapagliflozin after Transcatheter Aortic Valve Implantation (DapaTAVI) randomized trial.
2021
Aims Despite aortic stenosis (AS) relief, patients undergoing transcatheter aortic valve implantation (TAVI) are at increased risk of developing heart failure (HF) within first months of intervention. Sodium-glucose co-transporter 2 (SGLT-2) inhibitors have been shown to reduce the risk of HF hospitalization in individuals with diabetes mellitus (DM), reduced left ventricular ejection fraction (LVEF) and chronic kidney disease (CKD). However, the effect of SGLT-2 inhibitors on outcomes after TAVI is unknown. The Dapagliflozin after Transcatheter Aortic Valve Implantation (DapaTAVI) trial is designed to assess the clinical benefit and safety of the SGLT-2 inhibitor dapagliflozin in patients …
Λc+ Production and Baryon-to-Meson Ratios in pp and p -Pb Collisions at sNN=5.02 TeV at the LHC
2021
The prompt production of the charm baryon Λ c + and the Λ c + / D 0 production ratios were measured at midrapidity with the ALICE detector in p p and p -Pb collisions at s NN = 5.02 TeV . These new measurements show a clear decrease of the Λ c + / D 0 ratio with increasing transverse momentum ( p T ) in both collision systems in the range 2 p T 12 GeV / c , exhibiting similarities with the light-flavor baryon-to-meson ratios p / π and Λ / K S 0 . At low p T , predictions that include additional color-reconnection mechanisms beyond the leading-color approximation, assume the existence of additional higher-mass charm-baryon states, or include hadronization via coalescence can describe the dat…
El currículum oculto visual en los libros de texto de Educación Física: Una revisión sistemática
2021
RESUMEN: El presente estudio tiene como objetivo principal revisar las diferentes investigaciones relacionadas con el análisis de las imágenes de los libros de texto de Educación Física (EF) en la enseñanza obligatoria del sistema educativo español, en el período que comprende las leyes educativas de la Ley Orgánica 1/1990 de Ordenación General del Sistema Educativo (LOGSE), la Ley Orgánica 2/2006 de Educación (LOE) y la Ley Orgánica 8/2013 para la Mejora de la Calidad Educativa (LOMCE). Para ello se realizó una búsqueda sistemática siguiendo las pautas de PRISMA en las bases de datos de Dialnet, Google Scholar, Redalyc, Scielo, Scopus y Web of Science, seleccionando 20 artículos de 253 enc…
false
2021
Abstract. Foreland fold-and-thrust belts (FTBs) record long-lived tectono-sedimentary activity, from passive margin sedimentation, flexuring, and further evolution into wedge accretion ahead of an advancing orogen. Therefore, dating fault activity is fundamental for plate movement reconstruction, resource exploration, and earthquake hazard assessment. Here, we report U–Pb ages of syn-tectonic calcite mineralizations from four thrusts and three tear faults sampled at the regional scale across the Jura fold-and-thrust belt in the northwestern Alpine foreland (eastern France). Three regional tectonic phases are recognized in the middle Eocene–Pliocene interval: (1) pre-orogenic faulting at 48.…
La traducción de los textos de especialidad. Una perspectiva multidisciplinar
2021
La evolución de la actividad traductora y los grandes cambios tecnológicos de los que está siendo partícipe la sociedad actual han traído consigo la aparición de nuevas tipologías textuales y modalidades de traducción en ámbitos especializados. De este contexto surge la propuesta de poner de manifiesto cómo se están abordando esos desafíos desde diferentes vertientes de las lenguas de especialidad y así ofrecer un breve panorama sobre esta cuestión. Este volumen recoge una serie de estudios realizados por investigadoras nacionales e internacionales que abordan la traducción especializada desde su experiencia y que ilustran esta propuesta de perspectiva multidisciplinar con sus propios campo…
Nuclear Pore Complex Acetylation Regulates mRNA Export and Cell Cycle Commitment in Budding Yeast
2021
AbstractNuclear pore complexes (NPCs) mediate communication between the nucleus and the cytoplasm and regulate gene expression by interacting with transcription and mRNA export factors. Lysine acetyl-transferases (KATs) promote transcription through acetylation of chromatin-associated proteins. We find that Esa1, the KAT subunit of the yeast NuA4 complex, also acetylates the nuclear pore basket component Nup60 to promote mRNA export. Acetylation of Nup60 recruits to the nuclear basket the mRNA export factor Sac3, the scaffolding subunit of the Transcription and Export 2 (TREX-2) complex. Esa1-dependent nuclear export of mRNAs promotes entry into S phase, and is inhibited by the Hos3 deacety…
EU income stabilization tool: potential impacts, financial sustainability and farmer’s risk aversion
2021
AbstractThe Income Stabilization Tool, a risk management scheme introduced within the Common Agricultural Policy (CAP) 2014–2020, could help European Union farmers manage the income risks they face. This study assesses the potential impact of implementing this tool through the maximum level of contribution to the fund which determines an indifference to participate in the fund and its financial sustainability. The study relies on an expected utility approach and assesses the variability of loss ratios over time using a sample of Italian hazelnut farms as a case study. The participation depends on the level of farmers' contributions and their degree of risk aversion. However, the CAP public …
Exploiting redox activity of MIL-100(Fe) carrier enables carvacrol prolonged antimicrobial activity
2021
The design of efficient food contact materials that maintain optimal levels of food safety is of paramount relevance to reduce the increasing foodborne illnesses. In this work, we develop a smart composite MOF-based material that fosters a unique prolonged antibacterial activity. The composite is obtained by entrapping a natural preserving food molecule, carvacrol, into the mesoporous MIL-100(Fe) material following a direct and biocompatible impregnation method and obtaining particularly high payloads. By exploiting the intrinsic redox nature of MIL-100(Fe) material it is possible to achieve a prolonged activity against E. coli bacteria due to a triggered two-step carvacrol release of films…
Tumor-Derived Small Extracellular Vesicles Induce Pro-Inflammatory Cytokine Expression and PD-L1 Regulation in M0 Macrophages via IL-6/STAT3 and TLR4…
2021
Tumor-associated macrophages play a key role in promoting tumor progression by exerting an immunosuppressive phenotype associated with the expression of programmed cell death ligand 1 (PD-L1). It is well known that tumor-derived small extracellular vesicles (SEVs) affect the tumor microenvironment, influencing TAM behavior. The present study aimed to examine the effect of SEVs derived from colon cancer and multiple myeloma cells on macrophage functions. Non-polarized macrophages (M0) differentiated from THP-1 cells were co-cultured with SEVs derived from a colorectal cancer (CRC) cell line, SW480, and a multiple myeloma (MM) cell line, MM1.S. The expression of PD-L1, interleukin-6 (IL-6), a…
The Participation of 3,3,3-Trichloro-1-nitroprop-1-ene in the [3 + 2] Cycloaddition Reaction with Selected Nitrile N-Oxides in the Light of the Exper…
2021
The regioselective zw-type [3 + 2] cycloaddition (32CA) reactions of a series of aryl-substituted nitrile N-oxides (NOs) with trichloronitropropene (TNP) have been both experimentally and theoretically studied within the Molecular Electron Density Theory (MEDT). Zwitterionic NOs behave as moderate nucleophiles while TNP acts as a very strong electrophile in these polar 32CA reactions of forward electron density flux, which present moderate activation Gibbs free energies of 22.8–25.6 kcal·mol−1 and an exergonic character of 28.4 kcal·mol−1 that makes them irreversible and kinetically controlled. The most favorable reaction is that involving the most nucleophilic MeO-substituted NO. Despite P…
The tongue biofilm metatranscriptome identifies metabolic pathways associated with halitosis and its prevention
2021
AbstractHalitosis is an oral condition caused by an increase in the concentration of volatile sulfur compounds (VSCs), such as methyl mercaptan and hydrogen sulfide, generated as a consequence of bacterial metabolism on the tongue biofilm. Microbial communities on the tongue of halitosis patients have been studied by bacterial culture, 16S rRNA taxonomic studies and metagenomics. However, there are currently no reports on the microbial gene-expression profiles. In this study, we performed RNAseq of tongue coating samples from control individuals and halitosis patients with different levels and composition of VSCs, as determined by gas chromatography. In this metatranscriptomic study, the ac…
Boosting the in situ encapsulation of proteins with MIL-100(Fe): the role of strong Lewis acid centers
2021
Encapsulation of biomolecules using Metal-Organic Frameworks (MOFs) to form stable biocomposites has been demonstrated a valuable strategy for their preservation and controlled release, which has been however restricted to specific electrostatic surface conditions. We present a general in situ strategy that promotes the spontaneous MOF growth onto a broad variety of proteins, for the first time, regardless of their surface nature. We demonstrate that MOFs based on cations exhibiting considerable inherent acidity such as MIL-100(Fe) enable biomolecule encapsulation, including alkaline proteins previously inaccesible by the welldeveloped in situ encapsulation with azolate-based MOFs. In parti…
Nanodiamond Theranostic for Light-Controlled Intracellular Heating and Nanoscale Temperature Sensing
2021
Temperature is an essential parameter in all biological systems, but information about the actual temperature in living cells is limited. Especially, in photothermal therapy, local intracellular temperature changes induce cell death but the local temperature gradients are not known. Highly sensitive nanothermometers would be required to measure and report local temperature changes independent of the intracellular environment, including pH or ions. Fluorescent nanodiamonds (ND) enable temperature sensing at the nanoscale independent of external conditions. Herein, we prepare ND nanothermometers coated with a nanogel shell and the photothermal agent indocyanine green serves as a heat generato…
Media and Science Policy: Who Influences Whom Regarding Complementary and Alternative Medicines Regulation
2021
This paper analyses the synergies between press and politics in the debate on the regulation of complementary and alternative medicines (CAM) in Spain between 1979 and 2018. We argue that longitudinal analysis and comparison of this interaction and synergy reveal how the mainstream discourse has shifted. We use a dataset of news ( N = 2,059), a news sample ( n = 325) and a dataset of parliamentary records ( N = 86). Using both quantitative and qualitative approaches, the dynamics of the interaction between the different institutions and actors involved is assessed. Specifically, the study analyses the media and parliamentary attention to CAM issues (agenda setting), how CAM is addres…
The Abbey of Werden on the Frankish-Saxon Frontier. The Depictions of Landscapes and Emotions in the vita Gregorii and the vitae Liudgeri
2021
Abstract This study explores the depictions of landscapes and emotions in the ninthcentury hagiographies associated with Liudger: the three vitae Liudgeri and Liudger’s own vita Gregorii. The Frisian missionary founded the monastery of Werden, situated near the Frankish-Saxon frontier. It will be argued that previous historiography on early medieval frontiers has predominantly focused on the military nature of frontiers. Here, more cultural or symbolic natures of the Frankish-Saxon frontier will be discussed. The hagiographical narratives will be examined in conjunction with the notion of a frontier as a ‘third space’. The vitae Liudgeri shaped a discourse that legitimated Liudger’s transla…
Deciphering genomic heterogeneity and the internal composition of tumour activities through a hierarchical factorisation model
2021
Genomic heterogeneity constitutes one of the most distinctive features of cancer diseases, limiting the efficacy and availability of medical treatments. Tumorigenesis emerges as a strongly stochastic process, producing a variable landscape of genomic configurations. In this context, matrix factorisation techniques represent a suitable approach for modelling such complex patterns of variability. In this work, we present a hierarchical factorisation model conceived from a systems biology point of view. The model integrates the topology of molecular pathways, allowing to simultaneously factorise genes and pathways activity matrices. The protocol was evaluated by using simulations, showing a hi…
The spatial dimension of the French private rental markets: Evidence from microgeographic data in 2015
2021
International audience; This article draws on data collected by local rental observatories in 12 French urban units in 2015 to analyze the spatial dimension of hedonic rental prices in the private rental market through (i) the spatial heterogeneity between urban units and (ii) the wide variety of contextual and locational characteristics (socio-economic, environmental (dis)amenity, and accessibility) and flexible specifications to capture their potential non-linear influence on rent. Based on a joint test of equality of coefficients across all urban units, we find that hedonic prices differ for 75% of the characteristics, thereby justifying a detailed analysis of heterogeneity. Lyon, Nice, …
Future changes in North Atlantic winter cyclones in CESM-LENS. Part I: cyclone intensity, PV anomalies and horizontal wind speed
2021
Abstract. Strong low-level winds associated with extratropical cyclones can cause substantial impacts on society. The wind intensity and the spatial distribution of wind maxima may change in a warming climate; however, the involved changes in cyclone structure and dynamics are unclear. Here, such structural changes of strong North Atlantic cyclones in a warmer climate close to the end of the current century are investigated with storm-relative composites based on Community Earth System Model Large Ensemble (CESM-LENS) simulations. Furthermore, a piecewise potential vorticity inversion is applied to associate such changes in low-level winds to changes in potential vorticity (PV) anomalies at…
Bio-phenols determination in olive oils: Recent mass spectrometry approaches
2021
Extra virgin olive oil (EVOO) is largely used in Mediterranean diet, and it is also worldwide apprised not only for its organoleptic properties but also for its healthy effects mainly attributed to the presence of several naturally occurring phenolic and polyphenolic compounds (bio-phenols). These compounds are characterized by the presence of multiple phenolic groups in more or less complex structures. Their content is fundamental in defining the healthy qualities of EVOO and consequently the analytical methods for their characterization and quantification are of current interest. Traditionally their determination has been conducted using a colorimetric assay based on the reaction of Folin…
Rydberg Series Excitation of a Single Trapped Ca+40 Ion for Precision Measurements and Principal Quantum Number Scalings
2021
A complete set of spectroscopic data is indispensable when using Rydberg states of trapped ions for quantum information processing. We carried out Rydberg series spectroscopy for $n{S}_{1/2}$ states with $38\ensuremath{\le}n\ensuremath{\le}65$ and for $n{D}_{5/2}$ states with $37\ensuremath{\le}n\ensuremath{\le}50$ on a single trapped $^{40}{\mathrm{Ca}}^{+}$ ion. We determined the ionization energy of 2 870 575.582(15) GHz, 60 times more accurately as compared to the accepted value and contradicting it by 7.5 standard deviations. We confirm quantum defect values of ${\ensuremath{\delta}}_{{S}_{1/2}}=1.802\text{ }995(5)$ and ${\ensuremath{\delta}}_{{D}_{5/2}}=0.626\text{ }888(9)$ for $n{S}_…
Comparative effects of Er:YAG laser, and EDTA, MTAD, and QMix irrigants on adhesion of stem cells from the apical papilla to dentin: A scanning elect…
2021
Dentin conditioning can affect the adhesion of stem cells in endodontic regenerative treatments. This study aimed to assess the effects of the most commonly used endodontic irrigants, namely, ethylenediaminetetraacetic acid (EDTA), MTAD, and QMix in comparison with Er:YAG laser (as a novel modality for root canal disinfection) on the adhesion of stem cells from the apical papilla (SCAPs) to dentin.Forty dentin specimens were prepared and subjected to different treatments in 5 groups (n=8) of control, irrigation with EDTA for 1 minute, irrigation with MTAD for 5 minutes, irrigation with QMix for 5 minutes, and Er:YAG laser irradiation. SCAPs were isolated from third molar tooth buds that two…
European evidence-based recommendations for clinical assessment of upper limb in neurorehabilitation (CAULIN): data synthesis from systematic reviews…
2021
Abstract Background Technology-supported rehabilitation can help alleviate the increasing need for cost-effective rehabilitation of neurological conditions, but use in clinical practice remains limited. Agreement on a core set of reliable, valid and accessible outcome measures to assess rehabilitation outcomes is needed to generate strong evidence about effectiveness of rehabilitation approaches, including technologies. This paper collates and synthesizes a core set from multiple sources; combining existing evidence, clinical practice guidelines and expert consensus into European recommendations for Clinical Assessment of Upper Limb In Neurorehabilitation (CAULIN). Methods Data from systema…
Adaptive trends of sequence compositional complexity over pandemic time in the SARS-CoV-2 coronavirus
2021
In the brief time since the outbreak of the COVID 19 pandemic, and despite its proofreading mechanism, the SARS-CoV-2 coronavirus has accumulated a significant amount of genetic variability through recombination and mutation events. To test evolutionary trends that could inform us on the adaptive process of the virus to its human host, we summarize all this variability in the Sequence Compositional Complexity (SCC), a measure of genome heterogeneity that captures the mutational and recombinational changes accumulated by a nucleotide sequence along time. Despite the brief time elapsed, we detected many differences in the number and length of compositional domains, as well as in their nucleot…
Against the Grain: Spanish Trade Policy in the Interwar Years
2021
Estudiamos los efectos de los conflictos internos y los shocks externos sobre la política comercial española en el período de entreguerras. We study the effects of domestic conflict and external shocks on Spanish trade policy in the interwar period. Our account mobilizes a new granular dataset on exports and imports, and good-country level information on tariffs, trade agreements, and quotas. Into the Depression, the mainstay of policy was the tariff. The establishment of the Second Republic in 1931 was a turning point in policymaking. The new regime initiated bilateral trade negotiations. The Republic’s dilemma was to find countries willing to exchange market access. In a daunting internat…
Valorization of Solanum Elaeagnifolium Cavanilles Weeds as a New Lignocellulosic Source for the Formulation of Lignin-Urea-Formaldehyde Wood Adhesive
2021
Solanum Elaeagnifolium Cavanilles (SE-Cav) is an invasive plant that has been developed in Mediterranean basin countries especially in Morocco. This weeds which belongs to lignocellulosic biomass a...
Functionalized Poly(N-isopropylacrylamide)-Based Microgels in Tumor Targeting and Drug Delivery
2021
Over the past several decades, the development of engineered small particles as targeted and drug delivery systems (TDDS) has received great attention thanks to the possibility to overcome the limitations of classical cancer chemotherapy, including targeting incapability, nonspecific action and, consequently, systemic toxicity. Thus, this research aims at using a novel design of Poly(N-isopropylacrylamide) p(NIPAM)-based microgels to specifically target cancer cells and avoid the healthy ones, which is expected to decrease or eliminate the side effects of chemotherapeutic drugs. Smart NIPAM-based microgels were functionalized with acrylic acid and coupled to folic acid (FA), targeting the f…
Mass Spectrometry in Wastewater-Based Epidemiology for the Determination of Small and Large Molecules as Biomarkers of Exposure: Toward a Global View…
2021
Wastewater-based epidemiology (WBE) estimates collective consumption or exposure to chemicals or pathogens by monitoring the substances excreted in the population’s wastewater. Advances in mass spectrometry (MS) and the application of some clinical diagnostic tools and proteomics to wastewater fingerprinting have been linked to the discovery of new biomarkers and indicators of population health and are broadening the scope of WBE that nowadays cover not only small molecule biomarkers but also genetic biomarkers, large molecules, viruses, infection diseases, resistance, etc. This mini-review highlights recent WBE advances using MS and how this progress can create a fingerprint of a city’s he…
Physical activity and fat-free mass during growth and in later life.
2021
ABSTRACT Background Physical activity may be a way to increase and maintain fat-free mass (FFM) in later life, similar to the prevention of fractures by increasing peak bone mass. Objectives A study is presented of the association between FFM and physical activity in relation to age. Methods In a cross-sectional study, FFM was analyzed in relation to physical activity in a large participant group as compiled in the International Atomic Energy Agency Doubly Labeled Water database. The database included 2000 participants, age 3–96 y, with measurements of total energy expenditure (TEE) and resting energy expenditure (REE) to allow calculation of physical activity level (PAL = TEE/REE), and cal…
A new Diplura species from Georgia caves, Plusiocampa (Plusiocampa) imereti (Diplura, Campodeidae), with morphological and molecular data
2021
A new dipluran species, Plusiocampa (Plusiocampa) imereti Sendra & Barjadze sp. nov., from the deep zone in three caves in the Imereti region, Georgia, is described. This new troglobitic Plusiocampa is an addition to four others known Diplura from around the Black Sea region, two Dydimocampa and two Plusiocampa s. str. The present study also provides the first CO1 sequences for the Plusiocampinae taxa and the first molecular data for cave-dwelling Plusiocampa species. Although bootstrap values were low, the maximum-likelihood phylogenetic tree grouped Plusiocampa (P.) imereti Sendra & Barjadze sp. nov. with two Plusiocampa s. str. species from Eastern Europe. Morphologically, P. (P.…
Happy heart syndrome. frequency, characteristics, and outcome of takotsubo syndrome triggered by positive life events
2021
Background: The association with a preceding stressor is a characteristic feature of takotsubo syndrome (TTS). Negative emotions before TTS are common and led to the popular term "broken heart syndrome." In contrast, pleasant triggers ("happy heart syndrome") are rare and are scarcely investigated. Objectives: The authors analyzed the frequency, clinical characteristics, and prognostic implications of positive emotional stressors in the multicenter GEIST (GErman-Italian-Spanish Takotsubo) Registry. Methods: Patients enrolled in the registry were categorized according to their stressors. This analysis compared patients with pleasant emotional events with patients with negative emotional even…
Stochastic Approach for Optimal Positioning of Pumps As Turbines (PATs)
2021
A generic water system consists of a series of works that allow the collection, conveyance, storage and finally the distribution of water in quantities and qualities such as to satisfy the needs of end users. In places characterized by high altitude differences between the intake works and inhabited centres, the potential energy of the water is very high. This energy is attributable to high pressures, which could compromise the functionality of the pipelines
Chambered warm moist air eyelid warming devices – a review
2021
Background Eyelid warming is an important treatment for meibomian gland dysfunction (MGD). Specialized chambered devices, using warm moist air have been developed. Purpose To critically evaluate the literature on the safety and efficacy of chambered warm moist air devices in MGD treatment and pinpoint areas of future research. Methods PubMed and Embase were searched on 06 June 2021. The search term was ‘(warm OR heat OR steam OR goggle OR spectacle OR moist air) AND (meibomian OR MGD OR blepharitis OR eyelid OR dry eye OR DED)’. All relevant articles with available English full text were included. Results Eighteen articles assessing the application of chambered warm moist air eyelid warming…
Assessment of microalgae species, biomass and distribution from spectral images using a convolution neural network
2021
Artikkeliin "Assessment of microalgae species, biomass and distribution from spectral images using a convolution neural network" liittyvä aineisto koostuu seuraavista osista: 1.Transmittanssi-hyperspektrikuvat levänäytteistä kuvattuina 24-kuoppalevyllä 2.Biomassamääritykset elektronisella solulaskurilla 3.Opetus- ja validointiaineisto konvoluutioneuroverkolle 4.Testiaineisto konvoluutioneuroverkolle 5.Opetus-, validointi- ja testiaineiston käsittelyyn käytetty Python koodi 6.Seitsemään eri malliin käytetty Python koodi ja mallit itsessään The data and code related to the article "Assessment of microalgae species, biomass and distribution from spectral images using a convolution neural netwo…
Psychometric properties, validity and insights of the School Bullying Questionnaire (CIE-A) in secondary schools of the Valencian Community (Spain)
2021
Besides its several threats to health, welfare, social and academic development and performance of kids and teenagers, school bullying remains highlighted as one of the most relevant related challenges for educational, behavioral and legal sciences worldwide. Moreover, the lack of research on the field and the crucial but unattended need to count on psychometrically suitable and valid tools to detect school bullying make difficult understanding its contexts, dynamics and possible solutions. Objective The aim of this study was to thoroughly present in detail the psychometric properties and validity issues of the School Bullying Questionnaire (CIE-A) among secondary students. Methods A region…
Bayesian estimation of the specific shear and bulk viscosity of the quark-gluon plasma with additional flow harmonic observables
2021
The transport properties of the strongly coupled quark-gluon plasma created in ultrarelativistic heavy-ion collisions are extracted by Bayesian parameter estimate methods with the latest collision beam energy data from the CERN Large Hadron Collider. This Bayesian analysis includes sophisticated flow harmonic observables for the first time. We found that the temperature dependence of specific shear viscosity appears weaker than in the previous studies. The results prefer a lower value of specific bulk viscosity and a higher switching temperature to reproduce additional observables. However, the improved statistical uncertainties both on the experimental data and hydrodynamic calculations wi…