showing 36 of ~574560 from 574555 documents
An exon junction complex‐independent function of Barentsz in neuromuscular synapse growth
2021
The exon junction complex controls the translation, degradation, and localization of spliced mRNAs, and three of its core subunits also play a role in splicing. Here, we show that a fourth subunit, Barentsz, has distinct functions within and separate from the exon junction complex in Drosophila neuromuscular development. The distribution of mitochondria in larval muscles requires Barentsz as well as other exon junction complex subunits and is not rescued by a Barentsz transgene in which residues required for binding to the core subunit eIF4AIII are mutated. In contrast, interactions with the exon junction complex are not required for Barentsz to promote the growth of neuromuscular synapses.…
From obesity to Alzheimer's disease through insulin resistance
2021
Alzheimer's disease is one of the most frequent forms of dementia. It is a progressive neurodegenerative disease, characterized by presence of amyloid plaques and neurofibrillary tangles in the brain. Obesity is regarded as abnormal fat accumulation with deleterious impact on human health. There is full scientific evidence that obesity and the metabolic comorbidities (e.g., insulin resistance, hyperglycaemia, and type 2 diabetes) are related to Alzheimer's disease and likely in the causative pathway. Numerous studies have identified several overlapping neurodegenerative mechanisms, including oxidative stress, mitochondrial dysfunction, and inflammation. In this review, we present how obesit…
Speaking out against everyday sexism : Gender and epistemics in accusations of “mansplaining”
2021
In everyday interaction, subtle manifestations of sexism often pass unacknowledged and become internalised and thus perceived as “natural” conduct. The introduction of new vocabularies for referring to previously unnamed sexist conduct would presumably enable individuals to start problematising hitherto unchallengeable sexism. In this paper, we investigate whether and how these vocabularies empower people to speak out against sexism. We focus on the use of the term “mansplaining” which, although coined over 10 years ago, remains controversial and contested. Using Conversation Analysis and Membership Categorisation Analysis, this paper excavates the interactional methods individuals use to f…
Duration of untreated psychosis in first-episode psychosis is not associated with common genetic variants for major psychiatric conditions: results f…
2021
The EU-GEI Project is funded by the European Community’s Seventh Framework Programme under grant agreement No. HEALTH-F2-2010–241909 (Project EU-GEI).
Cytotoxicity of 4-hydroxy-N-(naphthalen-1-yl)-2-oxo-2H-chromene-3-carboxamide in multidrug-resistant cancer cells through activation of PERK/eIF2α/AT…
2021
After decades of research, multidrug resistance (MDR) remains a huge challenge in cancer treatment. In this study, the cytotoxic of 4-hydroxy-N-(naphthalen-1-yl)-2-oxo-2H-chromene-3-carboxamide (MCC1734) has been investigated towards multidrug-resistant cancer cell lines. MCC1734 exerted cytotoxicity on cell lines expressing different mechanisms of drug resistance (P-glycoprotein, BCRP, ABCB5, EGFR, p53 knockout) to a different extent. Interestingly, sensitive CCRF-CEM cells and multidrug-resistant P-gp-overexpressing CEM/ADR5000 cells represented similar sensitivity towards MCC1734, indicating MCC1734 can bypass P-gp-mediated resistance. Microarray-based mRNA expression revealed that MCC17…
The Paleolithic Site of San Teodoro
2021
Description of the Second Stop in The Excursion at the SanTeodoro Cave
Problèmes contemporains d'Afrique subsaharienne, n°120
2021
International audience
A Comprehensive Experimental and Theoretical Study on the [{(η5-C5H5)2Zr[P(µ-PNEt2)2P(NEt2)2P]}]2O Crystalline System
2021
The structure of tetraphosphetane zirconium complex C52H100N8OP10Zr21 was determined by single crystal X-ray diffraction analysis. The crystal belongs to the monoclinic system, space group P21/c, with a = 19.6452(14), b = 17.8701(12), c = 20.7963(14)Å, α = γ = 90°, β = 112.953(7)°, V = 6722.7(8)Å3, Z = 4. The electronic structure of the organometallic complex has been characterized within the framework of Quantum Chemical Topology. The topology of the Electron Localization Function (ELF) and the electron density according to the Quantum Theory of Atoms in Molecules (QTAIM) show no covalent bonds involving the Zr atom, but rather dative, coordinate interactions between the metal and the liga…
Uno strumento di insegnamento e apprendimento riflessivo nella formazione degli insegnanti al tempo del Covid: lo storytelling digitale
2021
Tra le varie forme narrative, negli ultimi anni si sta diffondendo l’uso del cosiddetto “storytelling digitale”, ovvero uno strumento attraverso il quale lo studente può raccontarsi e ritrovare tutti gli elementi caratterizzanti un’esperienza didattica vissuta. Il contributo si propone l'obiettivo di valutare in termini di soddisfazione e percezione del proprio apprendimento, la ricaduta dell’esperienza narrativa da parte degli studenti universitari che hanno frequentato a distanza nel primo semestre dell’anno accademico 2020-21, il corso di Docimologia previsto al secondo anno (cattedra M-Z) del Corso di Studi in Scienze della Formazione Primaria, attraverso l’impiego dello storytelling di…
Cardiovascular outcomes after cardiac resynchronization therapy in cardiac amyloidosis
2021
Abstract Aims Cardiac resynchronization therapy (CRT) is highly effective in dilated cardiomyopathy (DCM) patients with impaired left ventricular ejection fraction (LVEF) and left bundle block branch. In cardiac amyloidosis (CA) patients, left ventricular dysfunction and conduction defects are common, but the potential of CRT to improve cardiac remodelling and survival in this particular setting remains undefined. We investigated cardiovascular outcomes in CA patients after CRT implantation in terms of CRT echocardiographic response and major cardiovascular events (MACEs). Methods and results Our retrospective study included 47 CA patients implanted with CRT devices from January 2012 to Feb…
Un Punto di vista sul design italiano
2021
Il testo propone una lettura della storia del design essenzialmente come una struttura narrativa intorno al progetto; accanto alla complessità dei fatti e dei significati della Storia, emergono "microstorie" vissute e raccontate dai protagonisti, ma anche forme di raffinato e coinvolgente storytelling che alimenta bisogni e desideri. Il testo di Giovanni Lauda - che segue nel volume- viene quindi proposto come un esempio di un approccio poco comune oggi: un progettista che raccoglie la sfida di mettere in campo una lettura del design italiano contemporaneo dichiaratamente personale e contemporaneamente storicizzante. The text proposes a reading of the history of design as a narrative struct…
Severe asthma: One disease and multiple definitions
2021
Abstract Introduction There is, so far, no universal definition of severe asthma. This definition usually relies on: number of exacerbations, inhaled therapy, need for oral corticosteroids, and respiratory function. The use of such parameters varies in the different definitions used. Thus, according to the parameters chosen, each patient may result in having severe asthma or not. The aim of this study was to evaluate how the choice of a specific definition of severe asthma can change the allocation of patients. Methods Data collected from the Severe Asthma Network Italy (SANI) registry were analyzed. All the patients included were then reclassified according to the definitions of U-BIOPRED,…
Multi-criteria risk classification to enhance complex supply networks performance
2021
[EN] Management of complex supply networks is a fundamental business topic today. Especially in the presence of many and diverse stakeholders, identifying and assessing those risks having a potential negative impact on the performance of supply processes is of utmost importance and, as a result, implementing focused risk management actions is a current lively field of research. The possibility of supporting Supply Chain Risks Management (SCRM) is herein explored from a Multi-Criteria Decision-Making (MCDM)-based perspective. The sorting method ELimination Et Choix Traduisant la REalite (ELECTRE) TRI is proposed as a structural procedure to classify Supply Chain Risks (SCRs) into proper risk…
I percorsi di bonifica delle aziende infiltrate dalla criminalità organizzata
2021
Il mio intervento riguarderà i percorsi di bonifica delle aziende che a diverso titolo hanno subito dei tentativi di infiltrazione (o condizionamento) da parte della criminalità organizzata. Di seguito sono descritti tre differenti casi di aziende che hanno “intrapreso” un percorso di bonifica in seguito a tali accadimenti. In particolare, il primo fa riferimento a un’azienda risultata permeabile ai condizionamenti della criminalità organizzata e sottoposta alla misura dell’art. 34 del codice antimafia. Il secondo caso riguarda un’azienda operante in modo prevalente nel settore degli appalti pubblici, oggetto di tentativi di condizionamento della criminalità organizzata e destinataria di un…
Food: Ordinary Practice or Extraordinary Experience?
2021
Food and the practice of cooking hold a privileged place in contemporary aesthetics, as attested by the extensive literature that has been devoted to this topic. Food has been addressed in both Anglo-American and European studies from multiple points of view, including a cognitivist, pragmatist, phenomenological, everyday and somaesthetic perspective. In this essay I will try to identify a path that allows us to hold together these readings through the ordinary-extraordinary dichotomy. First, I shall analyze food through the lens of the extraordinary, taking into consideration some examples in which food is presented as a true work of art in museums or as an exceptional experience in increa…
Morphology, Rheological and Mechanical Properties of Isotropic and Anisotropic PP/rPET/GnP Nanocomposite Samples
2021
The effect of graphene nanoplatelets (GnPs) on the morphology, rheological, and mechanical properties of isotropic and anisotropic polypropylene (PP)/recycled polyethylene terephthalate (rPET)-based nanocomposite are reported. All the samples were prepared by melt mixing. PP/rPET and PP/rPET/GnP isotropic sheets were prepared by compression molding, whereas the anisotropic fibers were spun using a drawing module of a capillary viscometer. The results obtained showed that the viscosity of the blend is reduced by the presence of GnP due to the lubricating effect of the graphene platelets. However, the Cox–Merz rule is not respected. Compared to the PP/rPET blend, the GnP led to a slight incre…
Emotional status and fear in patients scheduled for elective surgery during COVID-19 pandemic: a nationwide cross-sectional survey (COVID-SURGERY)
2021
Abstract Background Fragmented data exist on the emotional and psychological distress generated by hospital admission during the pandemic in specific populations of patients, and no data exists on patients scheduled for surgery. The aim of this multicentre nationwide prospective cross-sectional survey was to evaluate the impact of pandemic on emotional status and fear of SARS-CoV-2 contagion in a cohort of elective surgical patients in Italy, scheduled for surgery during the COVID-19 pandemic. Results Twenty-nine Italian centres were involved in the study, for a total of 2376 patients surveyed (mean age of 58 years ± 16.61; 49.6% males). The survey consisted of 28 total closed questions, in…
The Role of Vitamin Deficiency in Liver Disease: To Supplement or Not Supplement?
2021
Over the past few years, growing interest has been shown for the impact of dietary requirements and nutritional factors on chronic diseases. As a result, nutritional programs have been reinforced by public health policies. The precise role of micronutrients in chronic liver disease is currently receiving particular attention since abnormalities in vitamin levels are often detected. At present, treatment programs are focused on correcting vitamin deficiencies, which are frequently correlated to higher rates of comorbidities with poor outcomes. The literature reviewed here indicates that liver diseases are often related to vitamin disorders, due to both liver impairment and abnormal intake. M…
Frailty Is Associated with Oxidative Stress in Older Patients with Type 2 Diabetes
2021
Aging has increased the prevalence of frailty, and type 2 diabetes (T2D) has also increased in prevalence. Diabetes and oxidative stress (OS) have been shown to be related to frailty. However, the exact mechanism by which it occurs is not fully known. Our aim was to analyze body composition in community-dwelling older diabetic people treated in our center and to evaluate the possible relation between OS, frailty, and body composition. We included 100 adults older than 65 years with T2D. We found that 15% were frail and 57% were prefrail. The patients included in the nonrobust group showed increased levels of OS. Our study shows that the presence of T2D in the geriatric population is associa…
Vectofocimetry: Dioptric power measurement in manual focimeters using power vectors
2021
Abstract Dioptric power measurement is classically achieved using manual focimeters. In this contribution, we present vectofocimetry as a novel methodology to be easily implemented in manual focimeters for improving their capabilities regarding dioptric power measurement. The new procedure is conceptually based on power vector formalism of dioptric power which represents the dioptric power as three values in the form of [M, J0, J45], it uses an iterative process of blur reduction, and it only requires a few modifications in the device that are easy-to-adapt and cost-effective. As a result, dioptric power measurements are easily and quickly obtained with comparable results to the reported on…
Comparison of inorganic chlorine in the Antarctic and Arctic lowermost stratosphere by separate late winter aircraft measurements
2021
Stratospheric inorganic chlorine (Cly) is predominantly released from long-lived chlorinated source gases and, to a small extent, very short-lived chlorinated substances. Cly includes the reservoir species (HCl and ClONO2) and active chlorine species (i.e., ClOx). The active chlorine species drive catalytic cycles that deplete ozone in the polar winter stratosphere. This work presents calculations of inorganic chlorine (Cly) derived from chlorinated source gas measurements on board the High Altitude and Long Range Research Aircraft (HALO) during the Southern Hemisphere Transport, Dynamic and Chemistry (SouthTRAC) campaign in austral late winter and early spring 2019. Results are compared to…
Is prolonged febrile syndrome associated with reactive thrombocytosis a possible association in the diagnosis of Takayasu’s arteritis? A case report
2021
Takayasu’s arteritis is a rare, systemic, inflammatory vasculitis of large blood vessels with an unknown aetiology that more frequently affects women of childbearing age with progression to stenosis, fibrosis or thrombogenesis. Clinical manifestations are associated either with inflammation of the vascular wall (including fever, myalgia, arthralgia, weight loss) or the development of aneurysms and extensive vascular lesions, which creates challenges for a differential diagnosis. This current report presents the case of a female Caucasian patient, aged 23 years, that presented herself repetitively at the hospital reporting symptoms including fever, productive cough, myalgia associated with …
Salvatore Caronia Roberti e la declinazione moderna della classicità nell'arredamento e nelle arti decorative
2021
La produzione progettuale di Salvatore Caronia Roberti (Palermo 1887 - 1970) nell’ambito degli arredi e delle arti decorative è ancora oggi poco indagata; questo nonostante Caronia Roberti sia da tempo considerato il più autorevole esponente in Sicilia della cosiddetta “Scuola di Basile”. A partire dall’inizio degli anni Trenta la vocazione accademica di Caronia assume sempre più complesse valenze, scongiurando quanto di genericamente tradizionalista aveva guidato la sua emancipazione dalla “maniera” modernista. La difficile sintesi fra la volontà di conseguire forme unitarie dall’austera solidità plastica, la sottintesa aspirazione ad un’architettura di superiore livello culturale e, in ul…
Sekcija “Dezinformācijas un sazvērestību radītie riski demokrātijai: Latvijas pieredzes pārlūkošana”: Kopsavilkumi : 2021. gada 25. un 26. februāris
2021
Latvijas Zinātnes padomes fundamentālo un lietišķo projektu programmas projekts “Dezinformācijas un sazvērestību radītie riski demokrātijai: Latvijas pieredzes pārlūkošana” (lzp-2019/1-0278)
Prävalenz von Internetsucht vor und während der COVID-19 Pandemie unter Studierenden der Johannes Gutenberg-Universität Mainz
2021
Zusammenfassung Ziel der Studie Internetsucht ist eine Verhaltensstörung, von welcher v. a. Jugendliche und junge Erwachsene, unter ihnen auch Studierende an Hochschulen betroffen sind. Die COVID-19 Pandemie führte aufgrund der Maßnahmen zu ihrer Eindämmung zu starken Einbußen sozialer Beziehungen, Studium und Freizeitaktivitäten der Studierenden. Diese Studie untersuchte, wie hoch die Prävalenz der Internetsucht unter Studierenden vor und während der COVID-19 Pandemie ausfällt und welche soziodemografischen (Geschlecht, Fachgruppe) und Gesundheitsfaktoren (Depressionssymptome, Einsamkeit, Ängste, Impulsivität) mit Internetsuchtsymptomen assoziiert sind. Methodik In der vorliegenden Studie …
Long-term outcome of patients with NSTEMI and nonobstructive coronary arteries by different angiographic subtypes
2021
Discordant data have been reported on the prognosis of myocardial infarction with nonobstructive coronary arteries (MINOCA). Moreover, few data are available on the impact of angiographic subtypes. The objectives of this study were to assess the prognostic impact on the long-term follow-up of the diagnosis of MINOCA and its angiographic subtypes.We included 591 consecutive patients with non-ST-segment elevation myocardial infarction (NSTEMI) who underwent coronary angiography. MINOCA was classified according to angiographic findings as smooth coronary arteries, mild irregularities (30% stenosis), and moderate atherosclerosis (30%-49% stenosis). The primary endpoint was a composite of mortal…
Cortical and Cerebellar Oscillatory Responses to Postural Instability in Parkinson's Disease
2021
Introduction: Posture and balance dysfunctions critically impair activities of daily living of patients with progressing Parkinson's disease (PD). However, the neural mechanisms underlying postural instability in PD are poorly understood, and specific therapies are lacking. Previous electrophysiological studies have shown distinct cortical oscillations with a significant contribution of the cerebellum during postural control tasks in healthy individuals.Methods: We investigated cortical and mid-cerebellar oscillatory activity via electroencephalography (EEG) during a postural control task in 10 PD patients with postural instability (PDPI+), 11 PD patients without postural instability (PDPI–…
Improved $K_{e3}$ radiative corrections sharpen the $K_{\mu 2}$--$K_{l3}$ discrepancy
2021
The measurements of $V_{us}$ in leptonic $(K_{\mu 2})$ and semileptonic $(K_{l3})$ kaon decays exhibit a $3\sigma$ disagreement, which could originate either from physics beyond the Standard Model or some large unidentified Standard Model systematic effects. Clarifying this issue requires a careful examination of all existing Standard Model inputs. Making use of a newly-proposed computational framework and the most recent lattice QCD results, we perform a comprehensive re-analysis of the electroweak radiative corrections to the $K_{e3}$ decay rates that achieves an unprecedented level of precision of $10^{-4}$, which improves the current best results by almost an order of magnitude. No larg…
Research on Unrealistic Optimism among HoReCa Workers as a Possible Future Hotspot of Infections
2021
As we are facing a new surge of the highly infectious delta variant of COVID-19, there is an urgent need for research to reduce the harm before this next wave hits. In the present paper, we present data that is alarming. We have found that HoReCa (hotels, restaurants, and catering services) workers, who are highly exposed to many new social interactions in close contact, present an unrealistic optimism (UO) bias: they perceive themselves as less at risk to this virus in comparison to others. From the literature, we already know that individuals holding this view are less involved in preventive actions and present more risky behaviors. In the face of the delta variant, this leads to the conc…
false
2021
Abstract Despite islands contributing only 6.7% of land surface area, they harbor ~20% of the Earth’s biodiversity, but unfortunately also ~50% of the threatened species and 75% of the known extinctions since the European expansion around the globe. Due to their geological and geographic history and characteristics, islands act simultaneously as cradles of evolutionary diversity and museums of formerly widespread lineages—elements that permit islands to achieve an outstanding endemicity. Nevertheless, the majority of these endemic species are inherently vulnerable due to genetic and demographic factors linked with the way islands are colonized. Here, we stress the great variation of islands…
Experimental characterization of a novel configuration of thermoelectric refrigerator with integrated finned heat pipes
2021
Abstract Thermoelectric refrigerating systems (TER) are environment-friendly technologies. They have several advantages such as low maintenance costs, are less cumbersome and long lifetime. However, these systems have low coefficient of performance and are limited in achieving low temperature levels. This study investigates a new configuration of TE refrigerator employing a novel arrangement of heat sinks with integrated flat and finned heat pipes. A mathematical model is firstly developed to predict transient temperatures and cooling limit time. An experimental characterization is then performed and it includes optimization of energy consumption, cooling time, temperature levels and TE ref…
ISHLT consensus document on lung transplantation in patients with connective tissue disease: Part I: Epidemiology, assessment of extrapulmonary condi…
2021
Patients with connective tissue disease (CTD) and advanced lung disease are often considered suboptimal candidates for lung transplantation (LTx) due to their underlying medical complexity and potential surgical risk. There is substantial variability across LTx centers regarding the evaluation and listing of these patients. The International Society for Heart and Lung Transplantation-supported consensus document on lung transplantation in patients with CTD standardization aims to clarify definitions of each disease state included under the term CTD, to describe the extrapulmonary manifestations of each disease requiring consideration before transplantation, and to outline the absolute contr…
Exploratory study of the hoaxes spread via WhatsApp in Spain to prevent and/or cure COVID-19
2021
Objective: To review the hoaxes’ characteristics spread through WhatsApp in Spain during COVID-19 lockdown and identify what kind of substances were promoted for consumption or application. Method: A phone number was activated to receive hoaxes via WhatsApp. A total of 2353 messages were collected, and among those 584 different hoaxes were identified and validated, between March 18 and April 18, 2020. From these 584 hoaxes, a sub-sample of 126 was selected, exclusively related to the object of study, and a content analysis table with fourteen registration fields was applied. Besides, the averages and medians of the quantitative fields were extracted. Results: Most of the messages received w…
Patient-Specific Analysis of Ascending Thoracic Aortic Aneurysm with the Living Heart Human Model
2021
In ascending thoracic aortic aneurysms (ATAAs), aneurysm kinematics are driven by ventricular traction occurring every heartbeat, increasing the stress level of dilated aortic wall. Aortic elongation due to heart motion and aortic length are emerging as potential indicators of adverse events in ATAAs
Epidermólisis ampollosa hereditaria: serie de casos
2021
Oleuropein multicompartment nanovesicles enriched with collagen as a natural strategy for the treatment of skin wounds connected with oxidative stres…
2021
Aim: Collagen-enriched transfersomes, glycerosomes and glytransfersomes were specifically tailored for skin delivery of oleuropein. Methods: Vesicles were prepared by direct sonication and their main physicochemical and technological properties were measured. Biocompatibility, protective effect and promotion of the healing of a wounded cell monolayer were tested in vitro using fibroblasts. Results: Vesicles were mainly multicompartment, small (∼108 nm), slightly polydispersed (approximately 0.27) and negatively charged (~-49 mV). Oleuropein was incorporated in high amounts (approximately 87%) and vesicles were stable during four months of storage. In vitro studies confirmed the low toxicit…