showing 36 of ~574560 from 574555 documents
Evolution climatique au Jurassique inférieur (Sinémurien supérieur) de la zone Nord-Ouest européenne, déduit de la minéralogie des argiles et des iso…
2021
International audience
Urban green spaces and childhood leukemia incidence: A population-based case-control study in Madrid.
2021
Abstract Background Childhood leukemia is the most common childhood cancer. To date, few risk factors related to predisposition have been identified; therefore, new hypotheses should be considered. Objective To explore the possible relationship of residential proximity to urban green spaces on childhood leukemia. Methods We conducted a population-based case control study in the metropolitan area of Madrid from 2000 to 2015. It included 383 incident cases and 1935 controls, individually matched by birth year, sex and area of residence. Using the geographical coordinates of the participants’ home residences, we built a proxy for exposure with four distances (250 m, 500 m, 750 m and 1 km) to u…
Positive gender congruency effects on shopper responses:Field evidence from a gender egalitarian culture
2021
National audience; This field study examined how customer-employee interactions are affected by the congruency between an employee's gender and the perceived gender image of the consumption context in one of the most gender equal cultures in the world (Scandinavia). Mystery shoppers had a service encounter with an employee across a set of physical commercial settings that were classified according to their gender image. The mystery shoppers noted the gender of the employee, provided employee evaluations, and indicated word-of-mouth (WOM) ratings. Shoppers who had a gender congruent service encounter (e.g., a female employee in a “feminine” consumption context) reported more favorable employ…
Design optimization for the quench protection of DTT's superconducting toroidal field magnets
2021
Abstract The paper is focused on the optimal design of Fast Discharge Unit (FDU) for the quench protection of the Toroidal Field (TF) magnets of the Divertor Tokamak Test facility (DTT), an experimental facility under construction in ENEA Frascati Research Centre (Rome, Italy). The FDU is a safety key component that protects the superconducting magnets when a quench is detected through the fast extraction of the energy stored in the magnets by adding a discharge dump resistor (DR) in the TF magnets circuit. A comparison between a fixed DR and a switched variable DR has been implemented by changing resistor parameters and by using multiple current control of the power electronics components …
Psoriasis and its impact on the clinical outcome of patients with pulmonary embolism
2021
Abstract Background Venous thromboembolism (VTE) is common and associated with high morbidity and mortality. Although chronic inflammation was not categorized as a traditional risk factor for VTE, chronic inflammation might increase the risk to develop VTE events. While studies confirmed an increased cardiovascular morbidity and mortality in psoriatic patients, data regarding the influence of psoriasis on patients' cardiovascular profile and on prognosis of patients with pulmonary embolism (PE) are sparse. Purpose We aimed to investigate the impact of psoriasis on prognosis of PE patients. Methods Hospitalized PE patients were stratified for psoriasis and the impact of psoriasis on outcome …
Preliminary development of a questionnaire to measure the extra-pulmonary symptoms of severe asthma
2021
Abstract Background Research into the effects of asthma treatments on the extra-pulmonary symptoms of severe asthma is limited by the absence of a suitable questionnaire. The aim was to create a questionnaire suitable for intervention studies by selecting symptoms that are statistically associated with asthma pathology and therefore may improve when pathology is reduced. Methods Patients attending a specialist asthma clinic completed the 65-item General Symptom Questionnaire (GSQ-65), a questionnaire validated for assessing symptoms of people with multiple medically unexplained symptoms. Lung function (FEV1%) and cumulative oral corticosteroids (OCS) calculated from maintenance dose plus ex…
18F-FDG PET/TC en infección e inflamación cardiovascular
2021
espanolEn cardiologia nuclear, el diagnostico de infeccion e inflamacion cardiovascular mediante PET/TC con [18F]FDG es de interes creciente, ya que esta tecnica ha mejorado la certeza diagnostica en pacientes con endocarditis infecciosa en protesis valvulares respecto a la ecocardiografia, en pacientes con dispositivos intracardiacos, cuya frecuencia de implantacion va en aumento debido al progresivo envejecimiento de la poblacion, asi como en aquellos con sospecha de vasculitis de grandes vasos. Son situaciones clinicas graves, en las que es necesario establecer lo antes posible el diagnostico correcto y el tratamiento adecuado, pues pueden producir complicaciones severas, alta mortalidad…
Grapevine and wine metabolomics-based guidelines for fair data and metadata management
2021
In the era of big and omics data, good organization, management, and description of experimental data are crucial for achieving high-quality datasets. This, in turn, is essential for the export of robust results, to publish reliable papers, make data more easily available, and unlock the huge potential of data reuse. Lately, more and more journals now require authors to share data and metadata according to the FAIR (Findable, Accessible, Interoperable, Reusable) principles. This work aims to provide a step-by-step guideline for the FAIR data and metadata management specific to grapevine and wine science. In detail, the guidelines include recommendations for the organization of data and meta…
A Multicenter Large Retrospective Database on the Personalization of Stereotactic Ablative Radiotherapy for Lung Metastases From Colon-Rectal Cancer:…
2021
PURPOSE/OBJECTIVE(S): stereotactic ablative radiotherapy (SABR) has been shown to increase survival rates in oligometastatic disease (OMD), but local control of colorectal metastases still remains poor. We aimed to identify potential predictive factors of SBRT response through a multicenter large retrospective database and to investigate how lung SBRT can impact on the progression to the polymetastatic disease (PMD). MATERIALS/METHODS: the study involved 22 centers, and was approved by the Ethical Committee (Prot. Negrar 2019-ZT). 1023 lung metastases treated with SBRT in 622 patients were reported. The median BED was 105 Gy10. Lesion diameter GTV, PTV volume, dose, fractionations, and site…
The Role of Endothelium in COVID-19
2021
The 2019 novel coronavirus, known as severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) or coronavirus disease 2019 (COVID-19), is causing a global pandemic. The virus primarily affects the upper and lower respiratory tracts and raises the risk of a variety of non-pulmonary consequences, the most severe and possibly fatal of which are cardiovascular problems. Data show that almost one-third of the patients with a moderate or severe form of COVID-19 had preexisting cardiovascular comorbidities such as diabetes mellitus, obesity, hypertension, heart failure, or coronary artery disease. SARS-CoV2 causes hyper inflammation, hypoxia, apoptosis, and a renin–angiotensin system imbalance …
Clinical and epidemiological profile of cleft lip and palate patients in Peru, 2006 ? 2019
2021
Background The purpose of this study was to determine the clinical-epidemiological profile of patients with cleft lip and / or palate in Peru from 2006 to 2019. Material and Methods This retrospective and cross-sectional study analyzed 3,923 patients with cleft lip and palate attended by surgical missions of the Operacion Sonrisa Peru from January 2006 to December 2019. The clinical profile of the patients treated included: type of cleft (cleft lip CL, cleft palate CP, cleft lip and palate CLP and submucosal SM), surgery performed (cheiloplasty, palatoplasty, cleft rhinoplasty, fistula repair, pharyngeal flap), surgical time according to number of interventions. Likewise, affiliation variab…
Environmentally-conditioned human rights: a good idea?
2021
The emergence of the rights of nature is a clear response to the current environmental crisis. But such trend is not to walk alone: it is to be espoused to the many still remaining human rights issues, otherwise the power and credibility of both are at danger. This chapter focuses on one of the many possible points of encounter between the rights of nature and human rights. It explores how they may be combined within biocultural rights—the basket of rights of indigenous peoples and local communities necessary to maintain their role as ecosystem stewards—and tries to understand what the consequences of combining nature and human interests as their foundations may be. In particula…
The Design and Sensitivity of JUNO's scintillator radiopurity pre-detector OSIRIS
2021
The European physical journal / C 81(11), 973 (2021). doi:10.1140/epjc/s10052-021-09544-4
Rationality, experiences or identity work? Sensemaking of emotionally tense experiences of organizational sustainability
2021
Purpose Although emotional tensions related to organizational sustainability have been identified, little is known about how employees aim to resolve such situations. This study aims to explore how employees use sensemaking to resolve emotionally tense situations concerning organizational sustainability. Design/methodology/approach The authors studied a case in which, while employees attached positive emotions to organizational sustainability, external stakeholders viewed it negatively. Specifically, the study analyzed how employees used sensemaking to resolve such tense experiences and how this sensemaking eventually influenced their actions. To this end, the authors interviewed 25 employ…
EPPUR IL GIUDICE NON BASTA: DE-RADICALIZZAZIONE JIHADISTA E FORME DI COOPERAZIONE EXTRA-GIUDIZIARIE
2021
SOMMARIO: 1. Introduzione. — 2. Radicalizzazione: significato, cause e differenziazioni oltre l’arena giudiziaria. — 2.1. La necessaria distinzione tra ‘‘radicalizzato’’ e ‘‘terrorista’’. — 2.2. Prevenzione e criminalizzazione — legislative e giurisdizionali — differenziate. — 3. Programmi e percorsi di ‘‘de-radicalizzazione’’. — 3.1. I percorsi individuali di de-radicalizzazione. — 4. Conclusioni.
Differences in Inter-Rectus Distance and Abdominopelvic Function between Nulliparous, Primiparous and Multiparous Women
2021
Widening of the inter-rectus distance (IRD) is highly prevalent among postpartum women and can lead to dysfunction of abdominopelvic muscles. The aim of this study was to evaluate the differences in IRD and abdominopelvic function between nulliparous, primiparous and multiparous women. A cross-sectional study was conducted on 75 women (25 nulliparous, 25 primiparous and 25 multiparous at 6 months postpartum). The participants underwent ultrasound assessment under three conditions (at rest, abdominal draw-in maneuver (ADIM) and curl-up) at two locations (2 cm above and 2 cm below the umbilicus). Furthermore, abdominopelvic muscle function was determined by prone, supine and side bridge tests…
La Pantera. Il primo movimento contro l'università neoliberale
2021
Il volume ricostruisce la storia della Pantera e dei processi riformisti posti in essere tra il 1989 e il 1990.
Recycled crustal carbon in the depleted mantle source of El Hierro volcano, Canary Islands
2021
The Canary Islands, in the eastern Atlantic, are among the most enigmatic Oceanic Island provinces on Earth, as the mantle source feeding its volcanism exhibits wide spatial heterogeneity and a multiplicity of sources. Multi-isotope whole-rock studies have long revealed the presence of a recycled oceanic crust/lithosphere component in the mantle source. However, noble gas systematics have been more challenging to interpret, and the available carbon isotope data is limited and cannot support/dismiss this interpretation. Here, we present the very first isotopic characterisation of CO2 and noble gases (He-Ne-Ar) in fluid inclusions (FI) in minerals hosted in mantle xenoliths from El Hierro, th…
Assessing the effectiveness of green roofs in enhancing the energy and indoor comfort resilience of urban buildings to climate change: Methodology pr…
2021
Abstract The effects of climate change on the built environment represents an important research challenge. Today, green roofs (GRs) represent a viable solution for enhancing energy and urban resilience in the face of climate change, as they can have a positive impact on the building's indoor thermal comfort and energy demand, as well as inducing various environmental benefits (easing urban heat island effects, improving the management of runoff water, reducing air pollution, etc.). Thus, it is important to be able to assess their effectiveness, both today and under future climate conditions, in order to evaluate whether they can also provide a valid long-term solution. In this paper, a sim…
Potere, consenso e dissenso nell’Ystoriola Langobardorum Beneventum degentium di Erchemperto
2021
Diversamente da quella narrata da Paolo Diacono nella «Historia Langobardorum», la storia dei Longobardi di Benevento fra l’VIII e il IX secolo, raccontata da Erchemperto nell’«Ystoriola Langobardorum Beneventum degentium», è una storia nella quale si alternano continuamente il bene e il male, Dio e Satana, il coraggio, la virtù, l’abnegazione da un lato e, dall’altro, la viltà, il tradimento, la perfidia. Personaggi positivi e personaggi negativi – insieme alle vicende delle quali, di volta in volta, essi sono protagonisti – si susseguono nell’«Ystoriola» a ritmo incalzante, e lo storico beneventano, talora in modo palese e scoperto, più spesso in maniera ellittica e sottintesa, manifesta …
Chiral Serum Pharmacokinetics of 4-Fluoroamphetamine after Controlled Oral Administration
2021
Abstract Over the last two decades, misuse of 4-fluoroamphetamine (4-FA) became an emerging issue in many European countries. Stimulating effects last for 4–6 hours and can impact psychomotor performance. The metabolism of amphetamine-type stimulants is stereoselective and quantification of (R)- and (S)-enantiomers has been suggested for assessing time of use. To date, no data on enantioselective pharmacokinetics is available for 4-FA in serum samples. An enantioselective liquid chromatography−tandem mass spectrometry (LC–MS-MS) method was developed using a chiral Phenomenex® Lux 3 μm AMP column. Validation of the method showed satisfactory selectivity, sensitivity, linearity (0.5–250 ng/mL…
LA TUTELA DEI CREDITORI PERSONALI DEL LEGITTIMARIO LESO O PRETERMESSO
2021
Il nostro ordinamento, a tutela di determinati vincoli familiari, segna un limite alla libertà di testare al fine di contrastare un possibile abuso della libertà testamentaria, che potrebbe anche concretarsi in un intento fraudatorio del testatore, d’accordo con lo stesso legittimario leso o pretermesso, ai danni dei creditori personali di quest’ultimo. Il tema si colloca al confine tra successione ereditaria e tutela dei creditori, con particolare riguardo all’esperibilità dell’azione surrogatoria e all’impugnabilità dell’eventuale rinunzia del legittimario all’azione di riduzione: da un lato, infatti, v’è l’interesse del testatore a tutelare il patrimonio ereditario dalle probabili aggres…
Value of Neurostimulation Plus Laryngeal Palpation to Predict Postoperative Vocal Fold Motility.
2021
ABSTRACT Background The aim of this study was to evaluate the reliability of intraoperative neuromonitoring through recurrent laryngeal nerve stimulation and simultaneous laryngeal palpation (NSLP) in predicting postoperative vocal cord palsy and in providing useful information in the decision to perform a staged surgery in initially planned total thyroidectomy. Materials and Methods A retrospective review was performed involving 552 patients for whom a total thyroidectomy was planned. In all patients, preoperative and postoperative laryngoscopy was performed. The incidence of vocal cord palsy was calculated on 1104 nerves at risk. Results Sensitivity and specificity of NSLP were 0.9411 and…
Methods of Condition Monitoring and Fault Detection for Electrical Machines
2021
Nowadays, electrical machines and drive systems are playing an essential role in different applications. Eventually, various failures occur in long-term continuous operation. Due to the increased influence of such devices on industry, industrial branches, as well as ordinary human life, condition monitoring and timely fault diagnostics have gained a reasonable importance. In this review article, there are studied different diagnostic techniques that can be used for algorithms’ training and realization of predictive maintenance. Benefits and drawbacks of intelligent diagnostic techniques are highlighted. The most widespread faults of electrical machines are discussed as well as techniques fo…
Necrotizing enterocolitis in the preterm: newborns medical and nutritional Management in a Single-Center Study
2021
AbstractNecrotizing enterocolitis (NEC) is a typical disorder of preterm newborns, with a high mortality and morbidity rate. The therapeutic and nutritional management of disease depends on several factors. Its prognosis is linked, in addition to the severity of the disease and the need for surgery, to a correct enteral feeding in these patients. This study aims to identify the clinical characteristics of 18 patients with NEC, evaluating the different therapeutic paths undertaken, the type of formula used and the survival rate of this population. Average time of enteral nutrition before the NEC onset was 11,3 ± 11,6 days, with an average fasting period since the onset of 24 ± 18.9 days. 77.…
Ramucirumab in patients with previously treated advanced hepatocellular carcinoma: Impact of liver disease aetiology.
2021
BACKGROUND & AIMS Hepatocellular carcinoma (HCC) is a common complication of chronic liver disease with diverse underlying aetiologies. REACH/REACH-2 were global phase III studies investigating ramucirumab in advanced HCC (aHCC) following sorafenib treatment. We performed an exploratory analysis of outcomes by liver disease aetiology and baseline serum viral load. METHODS Meta-analysis was conducted in patients with aHCC and alpha-fetoprotein (AFP) ≥400 ng/mL (N = 542) from REACH/REACH-2 trials. Individual patient-level data were pooled with results reported by aetiology subgroup (hepatitis B [HBV] or C [HCV] and Other). Pre-treatment serum HBV DNA and HCV RNA were quantified using Roche CO…
Physical activity, sugar-sweetened beverages, whole grain bread and insomnia among adolescents and psychological distress in adulthood: prospective d…
2021
Abstract Background In this study, we examined the relationship between low levels of physical activity, high consumption of sugar-sweetened beverages and low consumption of whole grain bread and experiencing insomnia in adolescence and psychological distress in young adults. Methods This prospective study was based on information retrieved from the Trøndelag Health Study (HUNT) in Norway and included adolescents (age 13–19) participating in Young-HUNT3 (2006–2008) and in HUNT4 (2017–2019) 11 years later (age 23–31). The study sample consisted of 2,230 participants (1,287 females and 943 males). The exposure variables collected in adolescence included self-reported physical activity, consum…
Il dono e la festa. Strategie relazionali per un’estetica politica
2021
Attraverso l’analisi di alcuni progetti artistici partecipativi (Alÿs; González-Torres; Tiravanija; Studio Azzurro) che si incentrano sui concetti di dono e di festa, il saggio mira a dimostrare come la relazione tra individui possa essere il fondamento per un’estetica politica. Il termine “politica” è da intendersi, in riferimento a Platone e Aristotele, come mutua cooperazione nello spazio della pólis, mentre il termine estetica si richiama all’idea di aisthesis, cioè una teoria della sensibilità. In questa prospettiva teorica le arti che si incentrano sul dono e sulla festa attivano strategie relazionali utili a sviluppare quella sensibilità che attraverso la cura e l’attenzione per l’al…
A Model‐Based Workflow to Benchmark the Clinical Cholestasis Risk of Drugs
2021
We present a generic workflow combining physiology-based computational modeling and in vitro data to assess the clinical cholestatic risk of different drugs systematically. Changes in expression levels of genes involved in the enterohepatic circulation of bile acids were obtained from an in vitro assay mimicking 14 days of repeated drug administration for 10 marketed drugs. These changes in gene expression over time were contextualized in a physiology-based bile acid model of glycochenodeoxycholic acid. The simulated drug-induced response in bile acid concentrations was then scaled with the applied drug doses to calculate the cholestatic potential for each compound. A ranking of the cholest…
An algebraic representation of Steiner triple systems of order 13
2021
Abstract In this paper we construct an incidence structure isomorphic to a Steiner triple system of order 13 by defining a set B of twentysix vectors in the 13-dimensional vector space V = GF ( 5 ) 13 , with the property that there exist precisely thirteen 6-subsets of B whose elements sum up to zero in V , which can also be characterized as the intersections of B with thirteen linear hyperplanes of V .
3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery.
2021
3D printing has been widely used for the personalization of therapies and on-demand production of complex pharmaceutical forms. Recently, 3D printing has been explored as a tool for the development of topical dosage forms and wound dressings. Thus, this review aims to present advances related to the use of 3D printing for the development of pharmaceutical and biomedical products for topical skin applications, covering plain dressing and products for the delivery of active ingredients to the skin. Based on the data acquired, the important growth in the number of publications over the last years confirms its interest. The semisolid extrusion technique has been the most reported one, probably …
Development and psychometric evaluation of the Anticipated Food Scarcity Scale (AFSS).
2021
Mass media extensively inform societies about events threatening the global food supply (e.g., pandemics or Brexit). Consumers exposed to such communication may perceive food resources as becoming scarcer. In line with the evolutionary account, these perceptions can shift decision-making in domains such as food preferences or prosociality. However, the current literature has solely focused on actual and past food insecurity experiences threatening mostly low-income families, thus neglecting the future-oriented perceptions among the general population. This paper broadens the food insecurity research scope by developing a new construct—anticipated food scarcity (AFS)—which is defined as the …
HD-RTI: an adaptive multi-light imaging approach for the quality assessment of manufactured surfaces
2021
International audience; Reflectance Transformation Imaging (RTI) is a technique for estimating surface local angular reflectance from a set of stereo-photometric images captured with variable lighting directions. The digitization of this information fully fits into the industry 4.0 approach and makes it possible to characterize the visual properties of a surface. The proposed method, namely HD-RTI, is based on the coupling of RTI and HDR imaging techniques. This coupling is carried out adaptively according to the response at each angle of illumination. The proposed method is applied to five industrial samples which have high local variations of reflectivity because of their heterogeneity of…
Public transportation and fear of crime at BRT Systems: Approaching to the case of Barranquilla (Colombia) through integrated choice and latent varia…
2021
Abstract Security perception and Fear of Crime (FoC) in urban scenarios have the potential to affect travel behavior, changing people’s travel choices and patterns. In this sense, the feeling of being “safe” or “at-risk” in public transportation not only depends on observable factors like illumination, travel companionship or transport crowding, but also on unobservable individual-specific latent attributes, among which fear of crime constitutes a major issue to consider in transport security policy-making. This study aimed to describe the relationships among sociodemographic features, travel situations, system-design features, and the Fear of Crime at three different locations (buses, bus …
What grafting materials produce greater alveolar ridge preservation after tooth extraction? A systematic review and network meta-analysis
2021
Abstract A systematic review and network meta-analysis was conducted to compare different bone-substitute materials used for alveolar ridge preservation after tooth extraction. The electronic search was carried out on Embase, PubMed, Cochrane Library, Web of Science, Scopus, LILACS, and grey literature up to March 22, 2020 (registration number INPLASY202030005). Only randomized controlled trials were included to answer the following PICOS question: ‘What grafting materials produce greater alveolar ridge preservation after tooth extraction?’ The primary outcomes were the alveolar width resorption 1 mm below the alveolar crest and buccal height resorption in millimeters. Of the 4379 studies i…
Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects
2021
Accumulation of senescent cells may drive age-associated alterations and pathologies. Senolytics are promising therapeutics that can preferentially eliminate senescent cells. Here, we performed a high-throughput automatized screening (HTS) of the commercial LOPAC®Pfizer library on aphidicolin-induced senescent human fibroblasts, to identify novel senolytics. We discovered the nociceptin receptor FQ opioid receptor (NOP) selective ligand 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole (MCOPPB, a compound previously studied as potential anxiolytic) as the best scoring hit. The ability of MCOPPB to eliminate senescent cells in in vitro models was further tested…