Portrait des jeunes NEET sur vingt ans : le cas des diplômé.e.s de CAP-BEP

2021

International audience; Le nombre de jeunes NEET (Not in Education, Employment or Training) est estimé en France à près de 2 millions, représentant 17 % des 15 à 29 ans. Cette population composite sur le plan du capital scolaire regroupe des jeunes qui ne sont pas exposés de manière identique aux aléas économiques et/ou qui n’ont pas les mêmes attentes vis-à-vis de l’emploi. Ce chapitre dévoile les difficultés rencontrées sur le marché du travail qui peuvent se cumuler et enfermer les jeunes diplômé·e·s de l’enseignement professionnel court dans une spirale de vulnérabilité, à travers quatre enquêtes du Céreq qui retracent leurs parcours. Pour quelles raisons ces diplômé·e·s de CAP-BEP (pre…

Simultaneous detection of hazardous skin whitening agents in Indian cosmetic products using a green chromatographic technique

2021

The present work mainly highlights the simultaneous detection of four skin whitening agents i.e. hydroquinone (HQ), resorcinol (RS), catechol (CC) and 3,3′-dichlorobenzidine (DCB) in facial creams and body lotion. Among these, the first three are positional isomers of dihydroxybenzene so simultaneous separation is difficult with the conventional reverse-phase high-performance liquid chromatographic technique (RP-HPLC). The selected skin whitening agents were detected in facial cream and body lotion using micellar liquid chromatography coupled to a photodiode array detector (MLC-PDA). In the present study, optimization of the method was accomplished using response surface methodology (RSM) w…

Advanced descriptors for long-range noncovalent interactions between SARS-CoV-2 spikes and polymer surfaces.

2021

The recent pandemic triggered numerous societal efforts aimed to control and limit the spread of SARS-CoV-2. One of these aspects is related on how the virion interacts with inanimate surfaces, which might be the source of secondary infection. Although recent works address the adsorption of the spike protein on surfaces, there is no information concerning the long-range interactions between spike and surfaces, experimented by the virion when is dispersed in the droplet before its possible adsorption. Some descriptors, namely the interaction potentials per single protein and global potentials, were calculated in this work. These descriptors, evaluated for the closed and open states of the sp…

Gendered Labor Market (dis)advantages in Nordic Welfare States. Introduction to the Theme of the Special Issue

2021

Gender equality has been named as one of the normative foundations of Nordic wel- fare states. This is reflected in how, year after year, Nordic states rank among the most gender egalitarian countries in the world (see, e.g., World Economic Forum 2020). In Nordic countries, the state has been, and continues to be, a central actor in shaping women’s citizenship, labor market opportunities, and caring roles. Especially publicly funded welfare services and policies that facilitate the reconciliation of work and care have played a major part in advancing women’s labor market participation (see, e.g., Bergquist et al. 1999; Borchorst & Siim 2002; Ellingsæter & Leira 2006; Siim & Stol…

Philadelphia chromosome-negative myeloproliferative neoplasms in younger adults: A critical discussion of unmet medical needs, with a focus on pregna…

2021

Abstract Myeloproliferative neoplasms (MPN) are traditionally regarded as a disease of older adults, though a not negligible fraction of cases occurs at a younger age, including women of childbearing potential. MPN in younger patients, indeed, offer several challenges for the clinical hematologist, that goes from difficulties in reaching a timely and accurate diagnosis to a peculiar thrombotic risk, with a relatively high incidence of thromboses in unusual sites (as the splanchnic veins or the cerebral ones). Moreover, the issue of pregnancy is recently gaining more attention as maternal age is rising and molecular screening are widely implemented, leading to a better recognition of these c…

Do Women in Nepal Like Playing a Mobile Game? MANTRA: A Mobile Gamified App for Improving Healthcare Seeking Behavior in Rural Nepal

2021

In Low and Middle Income Countries (LMIC), one of the causes of maternal and child mortality is a lack of medical knowledge and consequently the inability to seek timely healthcare. Mobile health (mHealth) technology is gradually becoming a universal intervention platform across the globe due to ubiquity of mobile phones and network coverage. MANTRA is a novel mHealth intervention developed to tackle maternal and child health issues through a serious mobile game app in rural Nepal, which demonstrated a statistically significant knowledge improvement in rural women. This paper explores the perceptions and usability of the MANTRA app amongst rural women and Female Community Health Volunteers …

Ripensare gli oggetti, riprogettare la società

2021

The essay introduces a series of classical essays by Bruno Latour on design and techniques, showing the relationships between Actor Network Theory and semiotics. In particular, the theoretical convergences and problematic nodes on the methodological level concerning the application of certain semiotic notions, such as that of actant and that of enunciation, within Bruno Latour's anthropology are discussed.

Is digital necrosis in COVID-19 caused by neutrophil extracellular traps: Potential therapeutic strategies

2021

Some of the COVID-19 patients present with ischemic lesions of their finger and toes. Standard anticoagulant therapy is usually unsuccessful for the treatment of this unique presentation of COVID-19. In this review current evidence is presented, which supports the hypothesis that these necrotic lesions are primarily related to the formation of neutrophil extracellular traps is blood vessels. Also, currently available and potential pharmaco-logical methods of the management of this unique thrombotic complication are discussed. Drugs that possibly could be used in COVID-19 patients suffering from acute ischemia of distal parts of the extremities particularly comprise DNase I and DNase1L3, whi…

Modelling and analysis of the influence of solar spectrum on the efficiency of photovoltaic modules

2021

Abstract The article presents the influence of changes in the solar radiation spectrum distribution on the properties of various photovoltaic modules, with particular emphasis on the scattered component. We compared the relative efficiency of the photovoltaic modules based on various semiconductor absorbers during bright and sunny, and cloudy summer days. Additionally, we presented the impact of the module tilt angle on the magnitude of the surface incident scattered component and on the efficiency of the module. The solar spectra for various weather conditions were estimated using specialised computer programmes,such as SolarSpectrum or SMARTS2, and we present here the validation results f…

Gluten-Free Diet Reduces Symptoms, Particularly Diarrhea, in Patients With Irritable Bowel Syndrome and Antigliadin IgG

2021

Background & Aims Many patients with irritable bowel syndrome (IBS) perceive that their symptoms are triggered by wheat-containing foods. We assessed symptoms and gastrointestinal transit before and after a gluten-free diet (GFD) in unselected patients with IBS and investigated biomarkers associated with symptoms. Methods We performed a prospective study of 50 patients with IBS (ROME III, all subtypes), with and without serologic reactivity to gluten (antigliadin IgG and IgA), and 25 healthy subjects (controls) at a university hospital in Hamilton, Ontario, Canada, between 2012 and 2016. Gastrointestinal transit, gut symptoms, anxiety, depression, somatization, dietary habits, and microbiot…

Lens-vault analysis and its correlation with other biometric parameters using swept-source OCT

2021

Purpose To measure lens vault (LV) and to assess its correlation with various ocular parameters in healthy eyes, using for all measurements the same high-resolution swept-source optical coherence tomographer (SS-OCT). Methods We prospectively recruited 67 Caucasian healthy patients whose mean age was 41.9 ± 12.4 years; only their right eye was included in the study. Data were all recorded with the ANTERION SS-OCT and comprised, for each patient, 5 consecutive measurements of LV, anterior chamber depth (ACD), lens thickness (LT), axial length (AL), white-to-white (WTW) distance, central corneal thickness (CCT), anterior chamber volume (ACV) and spur-to-spur (STS) distance. Results Mean LV wa…

Second-Order CASSCF Algorithm with the Cholesky Decomposition of the Two-Electron Integrals

2021

In this contribution, we present the implementation of a second-order complete active space–self-consistent field (CASSCF) algorithm in conjunction with the Cholesky decomposition of the two-electron repulsion integrals. The algorithm, called norm-extended optimization, guarantees convergence of the optimization, but it involves the full Hessian and is therefore computationally expensive. Coupling the second-order procedure with the Cholesky decomposition leads to a significant reduction in the computational cost, reduced memory requirements, and an improved parallel performance. As a result, CASSCF calculations of larger molecular systems become possible as a routine task. The performance …

Identification of novel drug resistance mechanisms by genomic and transcriptomic profiling of glioblastoma cells with mutation-activated EGFR.

2021

Abstract Aims Epidermal growth factor receptor (EGFR) is not only involved in carcinogenesis, but also in chemoresistance. We characterized U87.MGΔEGFR glioblastoma cells with constitutively active EGFR due to deletion at the ligand binding domain in terms of gene expression profiling and chromosomal aberrations. Wild-type U87.MG cells served as control. Materials and methods RNA sequencing and network analyses (Ingenuity Pathway Analysis) were performed to identify novel drug resistance mechanisms related to expression of mutation activated EGFR. Chromosomal aberrations were characterized by multicolor fluorescence in situ hybridization (mFISH) and array comparative genomic hybridization (…

Utilization of waste sodium sulfate from battery chemical production in neutral electrolytic pickling

2021

Abstract Several industrial activities produce metal sulfates, which are controlled by strict limitations for wastewater concentrations of sulfate. One emerging area where these activities occur is the production of lithium-ion battery chemicals in which sodium sulfates are formed because of cathode precursor co-precipitation. Several solutions for sulfate removal exist, but one option is to reuse the sulfate side stream in other processes to increase circular economy and atom efficiency. In this paper, the reuse of sodium sulfate solution in a steel industry pickling solution is considered. Neutral electrolytic pickling experiments were carried out to compare the pickling behavior of the e…

Prediction of Depression by Cognitive Function Above Core Affect

2021

The association between depression and cognitive function has been observed in a large number of studies, but there are no clear and robust mechanisms for this association. The aim of this study was to investigate how cognitive functions (working memory inhibition, executive functions cognitive control and psychomotor speed) in one model predict depression above current core affect in a sample of healthy individuals. The study involved 275 adults aged between 20 and 59 years (male 32.7%) and used the depression scale from DASS-42 questionnaire, the Swedish Core affect scale, and the cognitive function task battery. The results of hierarchical regression analysis suggest that the depression …

Fertility in McCune Albright syndrome female: A case study focusing on AMH as a marker of ovarian dysfunction and a literature review.

2021

Abstract Background The molecular basis of McCune Albright syndrome (MAS) is a recurrent GNAS Postzygotic gain of function sporadic mutation, resulting in a mosaic disease. Most of girls present precocious puberty, caused by the development of recurrent ovarian cysts with autonomous Hyperestrogenic stimulation. After menarche, the majority of patients with ovarian GNAS mutation have menstrual disturbances and infertility. Objectives We wanted to focus on the fertility of MAS females and propose an appropriate management, by a detailed case report and an exhaustive review of the literature on fertility and pregnancy in MAS females. Results We present the case of a 29-year-old MAS female, who…

Design optimization for the quench protection of DTT's superconducting toroidal field magnets

2021

Abstract The paper is focused on the optimal design of Fast Discharge Unit (FDU) for the quench protection of the Toroidal Field (TF) magnets of the Divertor Tokamak Test facility (DTT), an experimental facility under construction in ENEA Frascati Research Centre (Rome, Italy). The FDU is a safety key component that protects the superconducting magnets when a quench is detected through the fast extraction of the energy stored in the magnets by adding a discharge dump resistor (DR) in the TF magnets circuit. A comparison between a fixed DR and a switched variable DR has been implemented by changing resistor parameters and by using multiple current control of the power electronics components …

Estimators and confidence intervals of f2 using bootstrap methodology for the comparison of dissolution profiles

2021

Abstract Background and objectives: The most widely used method to compare dissolution profiles is the similarity factor f 2 . When this method is not applicable, the confidence interval of f 2 using bootstrap methodology has been recommended instead. As neither details of the estimator nor the types of confidence intervals are described in the guidelines, the suitability of five estimators and fourteen types of confidence intervals were investigated in this study by simulation. Methods: One million individual dissolution profiles were simulated for the reference and test populations with predefined target population f 2 values, where random samples of different sizes were drawn without rep…

Reconstitutions paléoenvironnementales des bassins finicarbonifères à permiens en contexte tardi-orogénique (N-E du Massif central) : implications pa…

2021

International audience

A Multicenter Large Retrospective Database on the Personalization of Stereotactic Ablative Radiotherapy for Lung Metastases From Colon-Rectal Cancer:…

2021

PURPOSE/OBJECTIVE(S): stereotactic ablative radiotherapy (SABR) has been shown to increase survival rates in oligometastatic disease (OMD), but local control of colorectal metastases still remains poor. We aimed to identify potential predictive factors of SBRT response through a multicenter large retrospective database and to investigate how lung SBRT can impact on the progression to the polymetastatic disease (PMD). MATERIALS/METHODS: the study involved 22 centers, and was approved by the Ethical Committee (Prot. Negrar 2019-ZT). 1023 lung metastases treated with SBRT in 622 patients were reported. The median BED was 105 Gy10. Lesion diameter GTV, PTV volume, dose, fractionations, and site…

Atypical functioning of female genitalia explains monandry in a butterfly

2021

Monandrous species are rare in nature, especially in animals where males transfer nutrients to females in the ejaculate. The proximate mechanisms responsible for monandry are poorly studied. In butterflies and moths, the male transfers a nutritious spermatophore into the corpus bursae (CB) of the female. The CB is a multifunctional organ that digests the spermatophore and has partial control of the post-mating sexual receptivity of the female. The spermatophore distends the CB and the post-mating sexual receptivity of the female is inversely proportional to the degree of distension. The CB of many butterfly species has a muscular sheath whose contractions mechanically contribute to digest t…

Chitin Deacetylase, a Novel Target for the Design of Agricultural Fungicides

2021

Fungicide resistance is a serious problem for agriculture. This is particularly apparent in the case of powdery mildew fungi. Therefore, there is an urgent need to develop new agrochemicals. Chitin is a well-known elicitor of plant immunity, and fungal pathogens have evolved strategies to overcome its detection. Among these strategies, chitin deacetylase (CDA) is responsible for modifying immunogenic chitooligomers and hydrolysing the acetamido group in the N-acetylglucosamine units to avoid recognition. In this work, we tested the hypothesis that CDA can be an appropriate target for antifungals using the cucurbit powdery mildew pathogen Podosphaera xanthii. According to our hypothesis, RNA…

Evolution climatique au Jurassique inférieur (Sinémurien supérieur) de la zone Nord-Ouest européenne, déduit de la minéralogie des argiles et des iso…

2021

International audience

Le lenti del Sud: informalità mediterranea e rivoluzioni post- pandemiche nel quartiere CEP di Palermo

2021

I fenomeni di abitazione informale si declinano in modalità eterogenee e complesse. La specificità dei contesti sud-europei induce a mettere in crisi i modelli che interpretano questi temi seguendo le esperienze anglosassoni o nord-europei e a sviluppare un filone di ragionamento teorico che tenti di scardinare il legame tra informalità e ritardo (economico, sociale, culturale). Questo contributo tenta dunque di fornire una chiave di lettura innovativa, a partire dal caso studio del quartiere CEP di Palermo, dove l’informalità non si declina esclusivamente nelle pratiche abitative ma si spinge oltre la dimensione privata, nello spazio pubblico. Se è vero che l’esperienza pandemica contempor…

Fostering ‘digital citizens’ in Norway: experiences of migrant mothers

2021

I argue that the fostering of ‘digital citizens’ in Norway is a societal project involving many actors, including parents, kindergartens and schools. The present article explores how migrant mothers in Norway experience handling their children’s use of digital media. Through institutional ethnographic exploration, I discover the ideals and conceptual terrains of what I have identified as the ‘digital Bildung’ discourse, consisting of dominant understandings of education, parenting, digitalisation and citizenship in Norwegian society. When performed in educational institutions, digital Bildung is formalised and organised by ruling texts, like government policies and curricula, but a main par…

EPV145/#82 Multicentric predictive score validation for nodal assessment in endometrial cancer patients: preliminary data

2021

Exploring new water soluble bridged dicopper(II) assemblies: Synthesis, structure, spectroscopic characterization, properties, and their interactions…

2021

Abstract Three new water soluble dimetallic copper(II) complexes, [Cu(H2O)5][Cu2(cpdp)(µ-O2As(CH3)2)]2Br2·13.83H2O·0.67CH3OH (1), [Cu2(Hcpdp)(µ-SO4)]·5H2O (2) and [Cu2(cpdp)(µ-pz)]·16H2O (3) (H3cpdp = N,N′-Bis[2-carboxybenzomethyl]-N,N′-Bis[2-pyridylmethyl]-1,3-diaminopropan-2-ol; (CH3)2AsO2− = cacodylate; SO42− = sulfate; pz− = pyrazolate) have been successfully synthesized and characterized for the investigation of coordination/binding aspects with biologically significant monosaccharide, d -glucosamine. Preparation of 1, 2 and 3 has been achieved by carrying out reaction of H3cpdp with stoichiometric quantities of CuCl2·2H2O/NaO2As(CH3)2·3H2O, CuSO4·5H2O and CuCl2·2H2O/1H-pyrazole, respe…

Tobacco-related cardiovascular risk in women: New issues and therapeutic perspectives

2021

Smoking is the main modifiable risk factor for stroke and myocardial infarction, particularly in women; its prevalence in France is evolving, and new patterns of nicotine consumption have emerged.To present contemporary data on smoking prevalence and the use of electronic cigarettes, and to describe current knowledge of the cardiovascular risk specificities and the effectiveness of withdrawal methods in women.We identified studies by searching the MEDLINE bibliographic database between 1995 and 2020, and the Weekly Epidemiological Bulletin (Bulletin Épidémiologique Hebdomadaire) published by the French health authorities.In recent years, smoking prevalence among French women has decreased o…

Urban green spaces and childhood leukemia incidence: A population-based case-control study in Madrid.

2021

Abstract Background Childhood leukemia is the most common childhood cancer. To date, few risk factors related to predisposition have been identified; therefore, new hypotheses should be considered. Objective To explore the possible relationship of residential proximity to urban green spaces on childhood leukemia. Methods We conducted a population-based case control study in the metropolitan area of Madrid from 2000 to 2015. It included 383 incident cases and 1935 controls, individually matched by birth year, sex and area of residence. Using the geographical coordinates of the participants’ home residences, we built a proxy for exposure with four distances (250 m, 500 m, 750 m and 1 km) to u…

Development of an in vitro neuroblastoma 3D model and its application for sterigmatocystin-induced cytotoxicity testing

2021

Abstract Given the increasing importance of establishing better risk assessments for mycotoxins, novel in vitro tools for the evaluation of their toxicity are mandatory. In this study, an in vitro 3D spheroid model from SH-SY5Y cells, a human neuroblastoma cell line, was developed, optimized and characterized to test the cytotoxic effects caused by the mycotoxin sterigmatocystin (STE). STE induced a concentration- and time-dependent cell viability decrease in spheroids. Spheroids displayed cell disaggregation after STE exposure, increasing in a dose-dependent manner and over time. STE also induced apoptosis as confirmed by immunofluorescence staining and Western blot. Following the decrease…

Preliminary development of a questionnaire to measure the extra-pulmonary symptoms of severe asthma

2021

Abstract Background Research into the effects of asthma treatments on the extra-pulmonary symptoms of severe asthma is limited by the absence of a suitable questionnaire. The aim was to create a questionnaire suitable for intervention studies by selecting symptoms that are statistically associated with asthma pathology and therefore may improve when pathology is reduced. Methods Patients attending a specialist asthma clinic completed the 65-item General Symptom Questionnaire (GSQ-65), a questionnaire validated for assessing symptoms of people with multiple medically unexplained symptoms. Lung function (FEV1%) and cumulative oral corticosteroids (OCS) calculated from maintenance dose plus ex…

18F-FDG PET/TC en infección e inflamación cardiovascular

2021

espanolEn cardiologia nuclear, el diagnostico de infeccion e inflamacion cardiovascular mediante PET/TC con [18F]FDG es de interes creciente, ya que esta tecnica ha mejorado la certeza diagnostica en pacientes con endocarditis infecciosa en protesis valvulares respecto a la ecocardiografia, en pacientes con dispositivos intracardiacos, cuya frecuencia de implantacion va en aumento debido al progresivo envejecimiento de la poblacion, asi como en aquellos con sospecha de vasculitis de grandes vasos. Son situaciones clinicas graves, en las que es necesario establecer lo antes posible el diagnostico correcto y el tratamiento adecuado, pues pueden producir complicaciones severas, alta mortalidad…

Case Report: Insulinoma Presenting as Excessive Daytime Somnolence

2021

Currently, undiagnosed insulinomas remain a difficult clinical dilemma because its symptoms in most cases can easily be misdiagnosed as other diseases. In this article, we present the case of a 14-year-old girl who presented to our hospital with recurrent episodes of excessive daytime sleepiness and abnormal behavior during sleep that had been going on for 3 months. Insulinoma is a rare neuroendocrine tumor that causes excessive release of insulin, resulting in episodes of hypoglycemia. It usually manifests as autonomic sympathetic symptoms. These symptoms resolved rapidly with the administration of glucose. After successful removal of the tumor, daytime sleepiness and abnormal nighttime be…

Non-autonomous rough semilinear PDEs and the multiplicative Sewing Lemma

2021

We investigate existence, uniqueness and regularity for local solutions of rough parabolic equations with subcritical noise of the form $du_t- L_tu_tdt= N(u_t)dt + \sum_{i = 1}^dF_i(u_t)d\mathbf X^i_t$ where $(L_t)_{t\in[0,T]}$ is a time-dependent family of unbounded operators acting on some scale of Banach spaces, while $\mathbf X\equiv(X,\mathbb X)$ is a two-step (non-necessarily geometric) rough path of H\"older regularity $\gamma >1/3.$ Besides dealing with non-autonomous evolution equations, our results also allow for unbounded operations in the noise term (up to some critical loss of regularity depending on that of the rough path $\mathbf X$). As a technical tool, we introduce a versi…

Esports fandom in the age of transmedia: the reception of the overwatch league

2021

In our article, we analyse the ways audiences engage with Overwatch esports and construct their fan relationships. We situate our research into several intersecting theoretical frames. To understand how Overwatch esports audiences engage with the esports through different media and media related practices we apply the framework of transmedia studies in our examination. To better understand how meanings related to esports are constructed through these practices we also draw from research on fandom and fan engagement. We reflect these findings on earlier research on sports fandom and esports viewership, enabling us to identify how Overwatch esports communities relate to traditional sports com…

EPPUR IL GIUDICE NON BASTA: DE-RADICALIZZAZIONE JIHADISTA E FORME DI COOPERAZIONE EXTRA-GIUDIZIARIE

2021

SOMMARIO: 1. Introduzione. — 2. Radicalizzazione: significato, cause e differenziazioni oltre l’arena giudiziaria. — 2.1. La necessaria distinzione tra ‘‘radicalizzato’’ e ‘‘terrorista’’. — 2.2. Prevenzione e criminalizzazione — legislative e giurisdizionali — differenziate. — 3. Programmi e percorsi di ‘‘de-radicalizzazione’’. — 3.1. I percorsi individuali di de-radicalizzazione. — 4. Conclusioni.