showing 36 of ~574560 from 574555 documents
Conversion of the Sensor Kinase DcuS to the Fumarate Sensitive State by Interaction of the Bifunctional Transporter DctA at the TM2/PAS
2021
The membrane-bound C4-dicarboxylate (C4DC) sensor kinase DcuS of Escherichia coli typically forms a protein complex with the C4DC transporter DctA. The DctA × DcuS complex is able to respond to C4DCs, whereas DcuS without DctA is in the permanent ON state. In DctA, the C-terminal helix 8b (H8b) serves as the site for interaction with DcuS. Here the interaction site in DcuS and the related structural and functional adaptation in DcuS were determined. The Linker connecting transmembrane helix 2 (TM2) and the cytosolic PASC (Per-ARNT-SIM) domain of DcuS, was identified as the major site for interaction with DctA-H8b by in vivo interaction studies. The Linker is known to convert the piston-type…
Enquête. Le grand hamster d'Alsace, à la pointe des PSE
2021
National audience; Il s'agit d'un article sur la reconnaissance (financière) des efforts faits par certains agriculteurs en vue de conserver des espèces emblématiques ; exemple avec le grand hamster d'Alsace. Une facette récurrente des atouts de l'agroécologie. À quelques kilomètres de Strasbourg, Laurent, Jean-Luc, Francis et Michel font partie des 300 agriculteurs rémunérés pour adapter leurs assolements afin de favoriser le grand hamster d’Alsace. La restauration, en quelques années, de cette espèce protégée a été permise par un paiement pourservice environnemental unique, car collectif et orienté sur les résultats. Un succès expliqué par les injonctions européennes, mais également par l…
Diffuse Lipomatosis of the Thyroid Gland
2021
Pembelajaran Picture and Picture untuk Meningkatkan motivasi dan Hasil Belajar Siswa Pada Materi Invertebrata
2021
<p>Penelitian ini bertujuan untuk meningkatkan motivasi dan hasil belajar siswa kelas X SMAS Katolik Caritas Maumere dengan menerapkan model pembelajaran picture and picture pada materi Invertebrata. Penelitian ini merupakan penelitian deskriptif dengan metode penelitian tindakan kelas (PTK). Penelitian dilaksanakan pada bulan Mei 2018 dengan subyek penelitian adalah 20 siswa kelas X SMAS Katolik Caritas Maumere tahun ajaran 2017/2018. Penelitian ini terdiri dari 2 siklus, setiap siklus terdiri dari 3 kali pertemuan. Hasil belajar ranah kognitif dan ranah afektif diperoleh dari hasil post-test juga lembar observasi. Hasil motivasi belajar diperoleh dari hasil lembar kuisioner pada sik…
The QELtLCUS questionnaire : an instrument for evaluating the learning to learn competence in university students
2021
La competencia 'aprender a aprender' es una competencia clave que la Comisión Europea (CE, 2006 y 2018) fijó para los sistemas educativos. Para su incorporación al diseño curricular y a los procesos de enseñanza-aprendizaje es ineludible disponer de instrumentos de evaluación rigurosos. Este trabajo se centra en el diseño y validación de un cuestionario cuantitativo estandarizado para evaluar su adquisición en estudiantes universitarios, dadas las limitaciones de los actualmente disponibles. Para ello se hizo uso de un diseño de validación de pruebas. Se utilizó una muestra de 1237 alumnos universitarios de tres universidades valencianas. Los resultados de consistencia interna y validez de …
Haavoittuvuuden kudelmat : digitaalinen subjekti ja haavoittuvuus datavetoista yhteiskuntaa käsittelevässä tutkimuskirjallisuudessa
2021
Artikkelissa tarkastellaan sitä, millaisia merkityksiä haavoittuvuudelle on annettu datavetoista yhteiskuntaa ja digitaalista subjektia koskevassa tutkimuskirjallisuudessa. Artikkeli perustuu kirjallisuuskatsaukseen, joka on tehty vuosina 2015–2020 ilmestyneistä haavoittuvuutta datafikaation kontekstissa käsittelevistä tieteellisistä julkaisuista. Kirjallisuushaut tehtiin yhteiskuntatieteiden alojen keskeisistä tietokannoista ja digitaalisista kirjastoista. Hakujen pohjalta tutkimuskirjallisuus järjestettiin neljään teemakokonaisuuteen: 1) datavalvonnan tuottamat haavoittuvuudet, 2) data tietämisen tapana ja osallisuutena, 3) digitaalisten subjektien kategorisointi ja näkyvyyden säätely sek…
Subjektin katoamisen uhkakuvat
2021
Arvio teoksesta: Andrejevic, Mark. 2020. Automated Media. New York & London: Routledge, 172 s. publishedVersion Non peer reviewed
Dataa näkyvissä: Läpinäkyvyys algoritmien ja datan journalistisessa hyödyntämisessä
2021
Läpinäkyvyyden käsite on noussut keskeiseksi viestinnän, median ja politiikan tutkimuksessa sekä viestinnän ja politiikan käytäntöjen eettisessä arvioinnissa. Läpinäkyvyyttä on esitetty keinoksi ylläpitää ja kasvattaa luottamusta journalistista työtä ja sen tuotteita kohtaan interaktiivisessa media- ja viestintäympäristössä. Tiedontuotannon ja päätöksenteon perustuessa yhä enemmän dataan ja sen prosessointiin läpinäkyvyys on noussut keskeiseksi käsitteeksi myös algoritmisen päätöksenteon kohdalla. Tässä artikkelissa tarkastelemme läpinäkyvyyden roolia dataa ja algoritmeja sekä journalismia koskevassa keskustelussa ja esitämme mahdollisuuksia dataan ja algoritmeihin tukeutuvan journalismin l…
Quality of Life in European Older Adults of SHARE Wave 7: Comparing the Old and the Oldest-Old
2021
CASP-12 (Control, Autonomy, Self-realization, and Pleasure scale) is one of the most common internationally used measures for quality of life in older adults, although its structure is not clearly established. Current research aims to test the factor structure of the CASP-12, so as to provide evidence on reliability and external validity, and to test for measurement invariance across age groups. Data from 61,355 Europeans (≥60 years old) from the Survey of Health, Ageing and Retirement in Europe wave 7 were used. CASP-12, EURO-D (European depression scale), self-perceived health, and life satisfaction measurements were included. Reliability and validity coefficients, competing confirmatory …
Vaakakupissa vaarat ja vastuu: Julkisen palvelun median arvot sosiaalisen median alustojen paineessa
2021
Sosiaalisen median alustat ovat muovanneet media-alan prosesseja ja käytäntöjä merkittävästi. Alustayritysten toimintaa ohjaavat erilaiset arvot ja tavoitteet kuin mediaorganisaatioita, mikä aiheuttaa toimijoiden välille ristiriitaa. Toimintatavoistaan ja arvoistaan sosiaalisessa mediassa joutuvat neuvottelemaan erityisesti julkisen palvelun mediayhtiöt, joiden peruskivenä ovat julkisen palvelun arvot. Tarkastelemme tässä artikkelissa suomalaisen julkisen palvelun mediayhtiön Yleisradion alustasuhdetta laadullisen haastatteluaineiston avulla. Kysymme, miten Yleisradiossa kuvataan ja perustellaan suhdetta sosiaalisen median alustoihin ja minkälaiseen arvopuheeseen suhteen kuvaaminen kytkeyty…
3d collagen hydrogel promotes in vitro langerhans islets vascularization through ad-mvfs angiogenic activity
2021
Adipose derived microvascular fragments (ad-MVFs) consist of effective vascularization units able to reassemble into efficient microvascular networks. Because of their content in stem cells and related angiogenic activity, ad-MVFs represent an interesting tool for applications in regenerative medicine. Here we show that gentle dissociation of rat adipose tissue provides a mixture of ad-MVFs with a length distribution ranging from 33–955 μm that are able to maintain their original morphology. The isolated units of ad-MVFs that resulted were able to activate transcriptional switching toward angiogenesis, forming tubes, branches, and entire capillary networks when cultured in 3D collagen type-…
Effect of Whole-Body Cryotherapy on Morphological, Rheological and Biochemical Indices of Blood in People with Multiple Sclerosis
2021
The aim of this study was to examine and assess the impact of a series of 20 whole-body cryotherapy (WBC) treatments on the biochemical and rheological indices of blood in people with multiple sclerosis. In this prospective controlled study, the experimental group consisted of 15 women aged 34–55 (mean age, 41.53 ± 6.98 years) with diagnosed multiple sclerosis who underwent a series of whole-body cryotherapy treatments. The first control group consisted of 20 women with diagnosed multiple sclerosis. This group had no intervention in the form of whole-body cryotherapy. The second control group consisted of 15 women aged 30–49 years (mean age, 38.47 ± 6.0 years) without neurological diseases …
L'invention urbaine d'un vignoble au xxe siècle. Le rôle décisif des réseaux culturels et savants dijonnais dans la construction de la Bourgogne viti…
2021
International audience
La reforma de la formación inicial del profesorado: Colaboración entre las universidades y los centros de enseñanza obligatoria. Experiencias europea…
2021
espanolIntroduccion Las politicas europeas de formacion del profesorado han fluctuado en los ultimos veinte anos en un intento de mejorar la eficacia y la calidad de la formacion del profesorado. En los ultimos cinco anos, varios paises europeos han propuesto o desarrollado diferentes tipos de reforma de la formacion del profesorado. En Espana, hace dos anos, en diciembre de 2018, el Gobierno convoco una macro-reunion y en febrero de 2020 anuncio en el Congreso una nueva iniciativa para mejorar la formacion del profesorado. Metodo Una vez realizado el diagnostico de la formacion, se analizaron diversos documentos de la CRUE, de la Conferencia de Decanos, del grupo Palma, de la Generalitat d…
From teacher training in Spain to educational practice in Senegal : an international cooperation project based on service learning for Pre-School and…
2021
Este artículo se encuentra disponible en la siguiente URL: https://revistas.uned.es/index.php/REEC/article/view/29393/23408 Este artículo pertenece al número "La educación en los países emergentes: ¿nuevos laboratorios educativos del siglo XXI?". Se presenta y analiza un proyecto de cooperación internacional para alumnado universitario español, en el que se combina la metodología formativa de aprendizaje servicio (ApS) con una estancia en un país emergente. Desde los grados de Educación Infantil y Educación Primaria de la Universidad CEU Cardenal Herrera, se planificó y ejecutó una intervención educativa en Djikesse (Senegal), concretamente en las escuelas de Educación Infantil (Guardería A…
Editorial: La educación en los países emergentes: ¿nuevos laboratorios educativos del siglo XXI?
2021
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Persepsi Masyarakat Lokal Terhadap Pengembangan Hutan Mangrove Sebagai Kawasan Ekowisata Di Kampung Ruar Distrik Biak Timur Kabupaten Biak Numfor
2021
The mangrove forest area of Kampung Ruar, East Biak District, is an area that has traditionally been a place for fishing and lime-making efforts by the community who have been hereditary. This condition raises questions from various parties whether this location is suitable to be developed as a mangrove ecotourism destination. Development of Mangrove Ecotourism by the Papua Provincial Forestry Service as a tourist attraction by utilizing local natural potential and supporting tourism policies in Biak Numfor Regency. This study aims to see the socio-cultural conditions of local communities in the Mangrove Forest Area of Kampung Ruar, Biak Timur District, Biak Numfor Regency as an ecotour…
Kirja-arvostelut alustataloudessa – esimerkkinä käyttäjälähtöiset arvostelut Instagramissa
2021
Kulttuurituotteita eivät sosiaalisen median aikakaudella enää arvostele julkisesti vain perinteisen median ammattikriitikot, vaan myös tavalliset ihmiset osallistuvat teosten julkiseen arvottamiseen erilaisilla digitaalisilla alustoilla. Tarkastelemme tässä artikkelissa kirjallisuusarvosteluja osana alustoitunutta kulttuurituotantoa esimerkkinämme käyttäjälähtöiset kirja-arvostelut erityisesti kuvasovellus Instagramissa. Instagramiin on vakiintunut kirjallisuuskeskusteluyhteisö, jota kutsutaan maailmanlaajuisesti nimellä Bookstagram mutta jolla on myös paikallisia tai alueellisia muotoja, kuten suomalainen Kirjagram. Kysymme, miten käyttäjäarvostelijat esiintyvät niissä arvostelulle määrite…
Los Planes Educacionales del MERCOSUR y la recontextualización de sus políticas en Brasil.
2021
espanolEl MERCOSUR surge en la decada de los 90 como parte de la estrategia economica de los paises del sur de America Latina. Sus objetivos han oscilado entre agendas marcadas por los movimientos de integracion de la region y los procesos de neoliberalizacion. La Educacion forma parte de su agenda como un fator de integracion regional que ha estado al servicio de sus objetivos mediante el Sector de Educacion del MERCOSUR (SEM). Los Planes de Accion del SEM desde 1998 han marcado la agenda politica educativa de los paises de la region. En este escenario, Brasil ha gozado de un protagonismo relevante en la region debido a la emergencia de su economia y su extension poblacional. No obstante,l…
En France, des services de renseignement sans vrais contre-pouvoirs
2021
contribution à un site web; International audience; Une nouvelle loi sur le renseignement est actuellement débattue au Parlement. À la clef, bien peu d’encadrement et une légitimation a posteriori de pratiques illégales.
New Fluorescent Heterocyclic Compounds Derived From 3-Cyanobenzanthrone
2021
The four-cyclic condensed aromatic ketone 7H-benz[de]anthracene-7-one and its derivatives belong to the class of important anthraquinoid dyes, including laser and luminescent dyes. Current work is ...
“Ya no tenemos fuerzas”. La gentrificación de los movimientos antigentrificación: una reflexión etnográfica
2021
El artículo analiza los desplazamientos y desposesiones simbólico-materiales de movimientos urbanos posicionados frente a la ciudad neoliberal. A partir de un estudio etnográfico en el barrio del Cabanyal (Valencia), se abordan las políticas urbanas y las movilizaciones vecinales en una gentrificación inacabada. El análisis muestra, en primer lugar, cómo el desplazamiento de la vecindad-activista y la desposesión de sus espacios colectivos no acarrea su desaparición, sino su transformación. En segundo lugar, la gentrificación y quienes la resisten, emergen como un mismo fenómeno contradictorio marcado por una expansión del urbanismo neoliberal a través de espacios no mercantilizados y cultu…
L'observation des bénéfices attendus ou espérés d'ateliers musicaux dans les EHPAD : réflexions méthodologiques
2021
International audience
The impact of orthognathic surgery on quality of life in individuals with oral clefts
2021
Summary Background/objectives To evaluate the relationships between individual, environmental, clinical factors and oral health-related quality of life (OHRQoL) in patients with cleft lip and palate (CLP) following orthognathic surgery. Materials and methods A follow-up study was conducted involving 69 adults with unilateral and bilateral CLP under orthodontic treatment. Interviews and oral examinations were conducted prior to orthognathic surgery (T0) to evaluate age, gender, psychological well-being, dental caries, malocclusion, social support, social networks, family income and education and OHRQoL. All participants were reviewed after 6 months (T1) to re-assess psychological well-being,…
Chromatin Maturity Index (CMI) in unfixed and live spermatozoa and Aniline Blue (AB) stained as an additional evaluation parameter in idiopathic male…
2021
Study question: To investigate whether idiopathic male infertility may be due to the presence of histones in motile spermatozoa using a modified AB staining protocol. Summary answer: No correlation between CMI in live motile spermatozoa, DNA Fragmentation Index (DFI) and other conventional seminal parameters were found in male infertile patients. What is known already: The AB stain discriminates between lysine-rich histones and arginine/cysteine-rich protamines. Transition from histones to protamines during spermatogenesis remodels chromatin packaging and abnormalities in the substitution of those proteins maybe interfere with seminal parameters and affect male infertility. The correlation …
Comparison of the intestinal microbiome of italian patients with multiple sclerosis and their household relatives
2021
Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system, caused by a combination of genetic and environmental factors. In recent years, a role in MS pathogenesis was assigned to the gut microbiota. However, different signatures of gut dysbiosis have been shown to depend on environmental factors, like diet and lifestyle. In this study, we compared the gut microbiome in MS patients and their household healthy relatives sharing lifestyle and environmental factors. Faecal metagenomic DNA was extracted and the V3–V4 regions of the conserved bacterial 16S ribosomal RNA gene were amplified and sequenced. While overall bacterial communities were similar, specific …
Towards a Framework to Support the Design of Esports Curricula in Higher Education
2021
Esports has generated an industry of increasing economic and cultural importance. In recent years, universities and other higher education institutions have responded to its growth by establishing undergraduate courses to satisfy the needs of innovators operating in the area. However, there is not yet consensus on what an esports curriculum should include. Despite being a technology-driven sector with ethical and professional dimensions that intersect computing, current ACM and IEEE curricula do not mention esports. Furthermore, existing courses tend to provide teaching and training on a wide variety of topics aside from those traditionally in computer science. These include: live events ma…
On backflow associated with oceanic and continental subduction
2021
SUMMARY A popular idea is that accretion of sediment at a subduction zone commonly leads to the formation of a subduction channel, which is envisioned as a narrow zone located above a subducting plate and filled with vigorously circulating accreted sediment and exotic blocks. The circulation can be viewed as a forced convection, with downward flow in the lower part of the channel due to entrainment by the subducting plate, and a ‘backflow’ in the upper part of the channel. The backflow is often cited as an explanation for the exhumation of high-pressure/low-temperature metamorphic rocks from depths of 30 to 50 km. Previous analyses of this problem have mainly focused on the restricted case …
Current Social and Rangeland Access Trends among Pastoralists in the Western Algerian Steppe
2021
International audience; In the western Algerian steppe, the public authorities have carried out actions aimed at rural development (agricultural development programs) and combating desertification (grazing reserves) to counter the significant and rapid loss of vegetation cover of pastures by overgrazing, and the consequent impacts on local livelihoods. In the Rogassa area, these actions have impacted land tenure and the ancestral and collective way of land use and access. These changes have caused transformations in lifestyle and pasture management. This research aims to characterize how such changes are affecting local pastoralists and what their perceptions are about them. A selective sam…
A generalizability measure for program synthesis with genetic programming
2021
The generalizability of programs synthesized by genetic programming (GP) to unseen test cases is one of the main challenges of GP-based program synthesis. Recent work showed that increasing the amount of training data improves the generalizability of the programs synthesized by GP. However, generating training data is usually an expensive task as the output value for every training case must be calculated manually by the user. Therefore, this work suggests an approximation of the expected generalization ability of solution candidates found by GP. To obtain candidate solutions that all solve the training cases, but are structurally different, a GP run is not stopped after the first solution …
Välitilinpäätös digitaalisesta historiantutkimuksesta
2021
Kirja-arvostelu Mats Fridlund, Mila Oiva & Petri Paju (toim), Digital Histories: Emergent Approaches within the New Digital History, Helsinki University Press, 2020, 360 sivua, ISBN (PDF): 978-952-369-021-9, https://doi.org/10.33134/HUP-5
false
2021
Orthodontic treatment to correct dental malocclusions leads to the formation of pressure zones in the periodontal ligament resulting in a sterile inflammatory reaction, which is mediated by periodontal ligament fibroblasts (PDLF). Leptin levels are elevated in obesity and chronic inflammatory responses. In view of the increasing number of orthodontic patients with these conditions, insights into effects on orthodontic treatment are of distinct clinical relevance. A possible influence of leptin on the expression profile of PDLF during simulated orthodontic mechanical strain, however, has not yet been investigated. In this study, PDLF were exposed to mechanical strain with or without differen…
The HIF1α-PFKFB3 Pathway: A Key Player in Diabetic Retinopathy
2021
Abstract Diabetic retinopathy (DR) is the leading cause of blindness for adults in developed countries. Both microvasculopathy and neurodegeneration are implicated in mechanisms of DR development, with neuronal impairment preceding microvascular abnormalities, which is often underappreciated in the clinic. Most current therapeutic strategies, including anti-vascular endothelial growth factor (anti-VEGF)-antibodies, aim at treating the advanced stages (diabetic macular edema and proliferative diabetic retinopathy) and fail to target the neuronal deterioration. Hence, new therapeutic approach(es) intended to address both vascular and neuronal impairment are urgently needed. The hypoxia-induci…
Acetylcholine receptors (muscarinic) in GtoPdb v.2021.2
2021
Muscarinic acetylcholine receptors (mAChRs) (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [50]) are activated by the endogenous agonist acetylcholine. All five (M1-M5) mAChRs are ubiquitously expressed in the human body and are therefore attractive targets for many disorders. Functionally, M1, M3, and M5 mAChRs preferentially couple to Gq/11 proteins, whilst M2 and M4 mAChRs predominantly couple to Gi/o proteins. Both agonists and antagonists of mAChRs are clinically approved drugs, including pilocarpine for the treatment of elevated intra-ocular pressure and glaucoma, and atropine for the treatment of bradycardia and poisoning by muscarinic age…
Monialaisen yhtiön johtamisen haaste: Tampella-yhtiö vuodesta 1958 vuoteen 1995
2021
Jyväskylän yliopistossa 11.12.2020 väitelleen Jouko Wacklinin lektio Tampellan monialayrityksen vaiheista. Diplomi-insinööri Wacklinin taloushistorian väitöskirja osoittaa, että yrityksen ylimmän johdon organisatoriset valmiudet ovat kriittinen tekijä yrityksen pitkän aikavälin kannattavan toiminnan varmistamiseksi.