showing 36 of ~574560 from 574555 documents
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2021
Fisheries exploitation can cause genetic changes in heritable traits of targeted stocks. The direction of selective pressure forced by harvest acts typically in reverse to natural selection and selects for explicit life histories, usually for younger and smaller spawners with deprived spawning potential. While the consequences that such selection might have on the population dynamics of a single species are well emphasized, we are just beginning to perceive the variety and severity of its propagating effects within the entire marine food webs and ecosystems. Here, we highlight the potential pathways in which fisheries-induced evolution, driven by size-selective fishing, might resonate throu…
Polypharmacy and the risk of drug-drug interactions and potentially inappropriate medications in hospital psychiatry.
2021
PURPOSE The aim of this study was to analyze the epidemiology of polypharmacy in hospital psychiatry. Another aim was to investigate predictors of the number of drugs taken and the associated risks of drug-drug interactions and potentially inappropriate medications in the elderly. METHODS Daily prescription data were obtained from a pharmacovigilance project sponsored by the Innovations Funds of the German Federal Joint Committee. RESULTS The study included 47 071 inpatient hospital cases from eight different study centers. The mean number of different drugs during the entire stay was 6.1 (psychotropic drugs = 2.7; others = 3.4). The mean number of drugs per day was 3.8 (psychotropic drugs …
Molecular modeling in cardiovascular pharmacology: Current state of the art and perspectives.
2021
Abstract Molecular modeling in pharmacology is a promising emerging tool for exploring drug interactions with cellular components. Recent advances in molecular simulations, big data analysis, and artificial intelligence (AI) have opened new opportunities for rationalizing drug interactions with their pharmacological targets. Despite the obvious utility and increasing impact of computational approaches, their development is not progressing at the same speed in different fields of pharmacology. Here, we review current in silico techniques used in cardiovascular diseases (CVDs), cardiological drug discovery, and assessment of cardiotoxicity. In silico techniques are paving the way to a new era…
Exercices de fiscalité des entreprises - Édition 2021-2022
2021
34e édition; National audience
Heterozygous HMGB1 loss-of-function variants are associated with developmental delay and microcephaly
2021
International audience; 13q12.3 microdeletion syndrome is a rare cause of syndromic intellectual disability. Identification and genetic characterization of patients with 13q12.3 microdeletion syndrome continues to expand the phenotypic spectrum associated with it. Previous studies identified four genes within the approximately 300 Kb minimal critical region including two candidate protein coding genes: KATNAL1 and HMGB1. To date, no patients carrying a sequence-level variant or a single gene deletion in HMGB1 or KATNAL1 have been described. Here we report six patients with loss-of-function variants involving HMGB1 and who had phenotypic features similar to the previously described 13q12.3 m…
Emergency Response Model as a part of the Smart Society
2021
Centralized hybrid emergency model with predictive emergency response functions is necessary when the purpose is to protect the critical infrastructure (CI). A shared common operational picture among Public Protection and Disaster Relief (PPDR) authorities means that a real-time communication link from the local level to the state-level exists. If a cyberattack would interrupt electricity transmission, telecommunication networks will discontinue operating. Cyberattack becomes physical in the urban and maritime area if an intrusion has not been detected. Hybrid threats require hybrid responses. The purpose of this qualitative research was to find out technological-related fundamental risks …
Schistosomal appendicitis: Case series and systematic literature review
2021
Background Globally, schistosomiasis affects at least 240 million people each year with a high proportion of cases in sub-Saharan Africa. The infection presents a wide range of symptoms mainly at the gastrointestinal and urogenital level. Cases of schistosomiasis-related appendicitis are seldom reported. The aim of the present study is to identify the prevalence of schistosomiasis-related appendicitis in Beira, Mozambique and compare to global prevalence. Methods We retrospectively reviewed all cases of appendicitis recorded from January 2017 to March 2020 at a single pathology department located in Beira in order to assess the prevalence of schistosomiasis. Moreover, we performed a systema…
Pyhä kulttuuriperintö?
2021
Uskonnollisesta musiikista osana peruskoulun toimintaa on puhuttu runsaasti viime vuosina. Artikkelin lähtökohtana onkin yhteiskunnallisen muutoksen ajama tarve uskonnollisen musiikin roolia perusopetuksessakoskevalle keskustelulle. Musiikinopetuksen historia suomalaisessa koulussa on merkittävällä tavalla uskonnollis-nationalistinen, minkä johdosta aikamme uskonnollisen musiikin roolia koskevan keskustelun juuria on etsittävä osin menneisyydestä. Artikkelin aineistoa ovat kansa- ja peruskoulun opetussuunnitelmat vuosilta 1925–2014. Opetussuunnitelmia analysoitiin laclaulaisella diskurssianalyysillä, jonka myötä aineistosta hahmottuivat uskonnollisen musiikin hegemonisen aseman tuottamisen …
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2021
Gold-assisted mechanical exfoliation currently represents a promising method to separate ultralarge (centimeter scale) transition metal dichalcogenide (TMD) monolayers (1L) with excellent electronic and optical properties from the parent van der Waals (vdW) crystals. The strong interaction between Au and chalcogen atoms is key to achieving this nearly perfect 1L exfoliation yield. On the other hand, it may significantly affect the doping and strain of 1L TMDs in contact with Au. In this paper, we systematically investigated the morphology, strain, doping, and electrical properties of large area 1L MoS2 exfoliated on ultraflat Au films (0.16-0.21 nm roughness) and finally transferred to an i…
Indefinite integrals from Wronskians and related linear second-order differential equations
2021
Many indefinite integrals are derived for Bessel functions and associated Legendre functions from particular transformations of their differential equations which are closely linked to Wronskians. A large portion of the results for Bessel functions is known, but all the results for associated Legendre functions appear to be new. The method can be applied to many other special functions. All results have been checked by differentiation using Mathematica.
Intratumor CMS Heterogeneity Impacts Patient Prognosis in Localized Colon Cancer
2021
Abstract Purpose: The consensus molecular subtypes (CMS) represent a significant advance in the understanding of intertumor heterogeneity in colon cancer. Intratumor heterogeneity (ITH) is the new frontier for refining prognostication and understanding treatment resistance. This study aims at deciphering the transcriptomic ITH of colon cancer and understanding its potential prognostic implications. Experimental Design: We deconvoluted the transcriptomic profiles of 1,779 tumors from the PETACC8 trial and 155 colon cancer cell lines as weighted sums of the four CMSs, using the Weighted In Silico Pathology (WISP) algorithm. We assigned to each tumor and cell line a combination of up to three …
Restoration and Enhancement of Historical Stereo Photos
2021
Restoration of digital visual media acquired from repositories of historical photographic and cinematographic material is of key importance for the preservation, study and transmission of the legacy of past cultures to the coming generations. In this paper, a fully automatic approach to the digital restoration of historical stereo photographs is proposed, referred to as Stacked Median Restoration plus (SMR+). The approach exploits the content redundancy in stereo pairs for detecting and fixing scratches, dust, dirt spots and many other defects in the original images, as well as improving contrast and illumination. This is done by estimating the optical flow between the images, and using it …
El litigio climático ante la responsabilidad intergeneracional
2021
El carácter intergeneracional del litigio climático plantea un interés sobre la protección jurídica de las generaciones futuras. La preocupación intergeneracional no es novedosa en el Derecho, sin embargo, debido al ascendiente número de litigios climáticos presentados por jóvenes en nombre propio y en el de las generaciones futuras para demandar mayor ambición climática han incorporado nuevas formas de observar este fenómeno. En esta contribución se lleva a cabo un estudio sobre sus implicaciones, la relevancia que puede tener el reconocimiento en normas internacionales e internas de los vínculos intergeneracionales, y cómo, a través del litigio climático, es posible vislumbrar nuevas form…
Treatment Needs and Service Delivery for Patients with Dual Disorders During the COVID-19 Pandemic: Findings From the WADD Survey
2021
Objective: The COVID-19 pandemic has posed a great challenge for the existing health systems. The restrictions imposed across countries on the movement of people and the realignment of health care services in response to the pandemic are likely to negatively affect the health status and delivery of mental health services to persons with dual disorders (PWDD). Methods: An online survey was conducted among mental health professionals involved in providing care to PWDD to better understand the problems encountered and identify potential solutions in providing continued treatment for PWDD during the COVID-19 pandemic. Results: The findings confirmed significant disruption in the delivery of tre…
Magnon transport in the presence of antisymmetric exchange in a weak antiferromagnet
2021
The Dzyaloshinskii-Moriya interaction (DMI) is at the heart of many modern developments in the research field of spintronics. DMI is known to generate noncollinear magnetic textures, and can take two forms in antiferromagnets: homogeneous or inter-sublattice, leading to small, canted moments and inhomogeneous or intra-sublattice, leading to formation of chiral structures. In this work, we first determine the strength of the effective field created by the DMI, using SQUID based magnetometry and transport measurements, in thin films of the antiferromagnetic iron oxide hematite, $\alpha$-Fe$_2$O$_3$. We demonstrate that DMI additionally introduces reconfigurability in the long distance magnon …
Visible Photoluminescence of Variable-Length Zinc Oxide Nanorods Embedded in Porous Anodic Alumina Template for Biosensor Applications
2021
Zinc oxide (ZnO) and porous anodic aluminum oxide (PAAO) are technologically important materials, rich with features that are of interest in optical applications, for example, in light-emitting and sensing devices. Here, we present synthesis method of aligned ZnO nanorods (NR) with 40 nm diameter and variable length in 150 to 500 nm range obtained by atomic layer deposition (ALD) of ZnO in pores of continuously variable thickness PAAO. The relative intensity of yellow (1.99 eV), green (2.35 eV), and blue (2.82 eV) photoluminescence (PL) components originating from the different types of defects, varied with non-monotonic dependency on the composite film thickness with a Fabry–Pérot like mod…
Positron Emission Tomography Imaging of Neurotensin Receptor-Positive Tumors with 68 Ga-Labeled Antagonists: The Chelate Makes the Difference Again
2021
Neurotensin receptor 1 (NTS1) is involved in the development and progression of numerous cancers, which makes it an interesting target for the development of diagnostic and therapeutic agents. A small molecule NTS1 antagonist, named [177Lu]Lu-IPN01087, is currently evaluated in phase I/II clinical trials for the targeted therapy of neurotensin receptor-positive cancers. In this study, we synthesized seven compounds based on the structure of NTS1 antagonists, bearing different chelating agents, and radiolabeled them with gallium-68 for PET imaging. These compounds were evaluated in vitro and in vivo in mice bearing a HT-29 xenograft. The compound [68Ga]Ga-bisNODAGA-16 showed a promising biod…
Age as a determining variable in the practice or abandonment of physical exercise among young people
2021
Background Numerous studies have reported a gradual decline in the practice of physical exercise with age, confirming high dropout rates in the adolescent period. The aim of this study was to investigate the motivation or barriers that lead to greater or lesser adherence to physical exercise among children and adolescents. Methods In this study, 1,081 individuals volunteered to participate [239 children (age: 10.89 ± .66 years) and 842 adolescents (age: 14.9 ± 1.75 years)]. For this purpose, we used the Self-Report on Motivation for Exercising (AMPEF) and Self-Report on Barriers to Exercising (ABPEF) questionnaires. Results The most significant motivational factors in the practice of physi…
Can Artificial Intelligence Interprete Legal Norms? A Problem of Practical Reason
2021
La formalización del razonamiento jurídico y, específicamente, de la interpretación es un viejo sueño de nuestra cultura. Hoy, la Inteligencia Artificial parece lista para cumplir esa tarea. Teóricos computacionales y lógicos están desarrollando herramientas técnicas para estructurar modelos formales de interpretación jurídica útiles para la Inteligencia Artificial. Sin embargo, estos esfuerzos han conseguido sólo formalizaciones abstractas, que no son capaces de resolver cuestiones materiales sobre la respuesta correcta ante un caso nuevo. Los algoritmos no pueden descubrir, ni evaluar, problemas humanos sin la ayuda de programadores; no pueden decidir entre hipótesis interpretativas alter…
Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modula…
2021
Small-molecular Toll-like receptor 7/8 (TLR7/8) agonists hold promise as immune modulators for a variety of immune therapeutic purposes including cancer therapy or vaccination. However, due to their rapid systemic distribution causing difficult-to-control inflammatory off-target effects, their application is still problematic, in particular systemically. To address this problem, we designed and robustly fabricated pH-responsive nanogels serving as versatile immunodrug nanocarriers for safe delivery of TLR7/8-stimulating imidazoquinolines after intravenous administration. To this aim, a primary amine-reactive methacrylamide monomer bearing a pendant squaric ester amide is introduced, which i…
Ketogenic Diet Decreases Alcohol Intake in Adult Male Mice
2021
The classic ketogenic diet is a diet high in fat, low in carbohydrates, and well-adjusted proteins. The reduction in glucose levels induces changes in the body’s metabolism, since the main energy source happens to be ketone bodies. Recent studies have suggested that nutritional interventions may modulate drug addiction. The present work aimed to study the potential effects of a classic ketogenic diet in modulating alcohol consumption and its rewarding effects. Two groups of adult male mice were employed in this study, one exposed to a standard diet (SD, n = 15) and the other to a ketogenic diet (KD, n = 16). When a ketotic state was stable for 7 days, animals were exposed to the oral self-a…
"De 1967 à 1989 des journées ordinaires de télévision", in Le Pajolec et Tillier (ed.)Des histoires, des images, Mélanges offerts à Myriam Tsikounas
2021
International audience; L'image, ou plutôt les images et les représentations, qu’elles soient matérielles ou mentales, sont au centre des essais réunis dans ce volume, qui couvre un vaste domaine allant du cinéma soviétique aux addictions, des imaginaires parisiens aux feuilletons télévisés, des figurations du crime aux mises en scène de l’histoire, et s’articule autour d’une même notion, celle de « circulations ».
Kokopäiväpedagogiikka ja sen kehittäminen varhaiskasvatuksessa
2021
Kokopäiväpedagogiikka on noussut keskeiseksi toimintatavaksi suomalaisissa päiväkodeissa. Se on myös useissa paikallisissa varhaiskasvatussuunnitelmissa toiminnan lähtökohtana, vaikka käsitteen tieteellinen määrittely on kesken ja käytännön tulkinnat vaihtelevat. Ehkä juuri näiden syiden vuoksi aihe herättää paljon keskustelua ja kiinnostusta. Kokopäiväpedagogiikka onkin vielä toistaiseksi ennen kaikkea varhaiskasvatuksen arkisanastoa. Se voi kuitenkin tutkimuksen avulla kehittyä tieteelliseksi käsitteeksi tai – kehityksen suunnasta riippuen – keskittyä pikemminkin varhaiskasvatuksen pedagogista työtä ohjaavaksi käsitteeksi. Erityinen huomio kokopäiväpedagogiikkaa koskevissa keskusteluissa …
Género y tortura. Simone de Beauvoir y Gisèle Halimi ante el caso de Djamila Boupacha
2021
La primera denuncia de violencia sexual como práctica de tortura en la guerra de Argelia se debe a Djamila Boupacha. Su causa fue defendida ante los tribunales argelinos y franceses por la abogada feminista, Gisèle Halimi, y tuvo una gran repercusión pública gracias al apoyo de Simone de Beauvoir y a la movilización de un comité conformado sobre todo por mujeres, en el intento de dar relevancia política y jurídica a un asunto destinado a permanecer oculto. El trabajo valora el enfoque anticolonial y antipatriarcal con que se afrontó el caso, analiza todo el proceso judicial y llama la atención sobre aquellos elementos que prefiguran la evolución del derecho hacia una justicia de género.
Päivähoidosta varhaiskasvatukseen : pedagogisen toiminnan edellytykset suomalaisessa päivähoidossa ja varhaiskasvatuksessa
2021
Suomessa päivähoidon ja varhaiskasvatuksen vaikuttavuuden yhtenä mittarina on ollut koulussa tai työelämässä menestyminen. Päivähoidolle ja varhaiskasvatukselle asetetut tavoitteet ovat aina tavalla tai toisella liittyneet yhteiskunnan taloudellispoliittisiin olosuhteisiin, josta käsin ne ovat ohjanneet myös toiminnan sisältöjä ja laatua. Laadunarvioinnin lähtökohtana ovat olleet palvelujärjestelmän mahdollisuudet vastata työelämän ja perheen tarpeisiin. Lasten kokonaisvaltaiseen oppimiseen ja hyvinvointiin tähtäävän pedagogiikan arviointi on sen sijaan jäänyt vähemmälle huomiolle. Tässä katsauksessa keskitytään tarkastelemaan päivähoidossa ja varhaiskasvatuksessa tapahtuneiden rakenteellis…
La idea de epigénesis en la obra de W. Harvey: Una lectura organicista
2021
espanolEste trabajo plantea desde una perspectiva historico-filosofica una reflexion sobre la idea de epigenesis en la obra de W. Harvey Exercitationes de generatione animalium (1651). El objetivo es contribuir a esclarecer la singular concepcion que el medico ingles tiene de esta idea, comunmente vinculada a la tradicion mecanicista. Harvey desarrolla su vision de la embriogenesis como un proceso que no puede ser comprendido desde las categorias del arte humano, como se desprende de las criticas a su maestro Fabricius. Tampoco es exacto decir que su posicion sea animista. Una inmersion en esta ultima cuestion nos mostrara su concepcion organica del alma, en continuacion con la tradicion ar…
El textualismo
2021
El textualismo es una teoría prescriptiva de la interpretación jurídica que defiende una metodología específica para decir el derecho en las materias legisladas. Según ella, quien interpreta debe declarar el significado público del texto legal y respetar en todo caso lo que el texto transmite, salvo cuando haya errata o error. El artículo expone la emergencia del textualismo en los Estados Unidos de América y su contraste con las teorías a las que desafía, particularmente el instrumentalismo, el intencionalismo y el finalismo. Se aborda también la asociación del textualismo con el originalismo, y se examina el reto crucial del textualismo, que es dar con una tesis semántica que vincule plau…
Pseudorhynchus raggeanus nomen novum
2021
Massa, Bruno (2021): Pseudorhynchus raggeanus nomen novum. Zootaxa 4991 (3): 592-592, DOI: https://doi.org/10.11646/zootaxa.4991.3.9
Korona opettajan osaamisen haastajana
2021
Tarkastelemme suomalaisen opettajan osaamista suhteessa korona-ajan tuomiin uusiin opettajuuden haasteisiin. Opettajan työ on monipuolista osaamista edellyttävää asiantuntijatyötä. Opettajan keskeinen osaaminen on koottu seitsemän yliopiston yhteistyönä tutkimusperustaiseen Opettajan osaamisen karttaan. Siinä opettajan ammatillinen kehittyminen nähdään jatkumona opiskelijavalintavaiheesta koulutuksen kautta työelämään. Keväällä 2020 koronapandemia muutti opettajan työtä radikaalisti. Siirtyminen etäopetukseen ja oppijoiden tukeminen kriisissä ovat asettaneet opettajien osaamiselle uudenlaisia haasteita. Koronatilanteen eri vaiheissa ovat korostuneet erityisesti kolme näkökulmaa Opettajan os…
Higher-order corrections to exclusive heavy vector meson production
2021
We present results for higher-order corrections to exclusive $\mathrm{J}/\psi$ production. This includes the first relativistic correction of order $v^2$ in quark velocity, and next-to-leading order corrections in $\alpha_s$ for longitudinally polarized production. The relativistic corrections are found to be important for a good description of the HERA data, especially at small values of the photon virtuality. The next-to-leading order results for longitudinal production are evaluated numerically. We also demonstrate how the vector meson production provides complementary information to the structure functions for extracting the initial condition for the small-$x$ evolution of the dipole-pr…
La revanche des coquelicots
2021
National audience
Utopioita ja toteutuneita haaveita : suomalaiset työläisnuoret maailman nuorisofestivaaleilla
2021
Arvosteltu teos: Koivunen, Pia 2020: Rauhanuskovaiset: suomalaiset maailman nuorisofestivaaleilla 1940–1950-luvuilla. Helsinki: Suomalaisen Kirjallisuuden Seura. s. 327.
Cytomegalovirus‐specific T‐cell immunity and DNAemia in patients with chronic lymphocytic leukaemia undergoing treatment with ibrutinib
2021
De la teoría crítica de Habermas a la teoría discursiva del derecho y la democracia
2021
El objetivo de este artículo es analizar las consecuencias de la teoría habermasiana del derecho y la democracia [1992] para su modelo de teoría crítica como teoría de la acción comunicativa [1981]. Se defiende que semejante teoría significa elintento de Habermas por corregir la dicotomizaión previamente mantenida entre “sistema” y “mundo de la vida”. Para apoyar esta interpretación, en primer lugar se presenta el significado de la teoría crítica de Habermas como teoría de la acción comunicativa, poniendo el foco en la dicotomía “sistema/mundo de la vida”, en la tesis de la colonización interna y en algunos problemas vinculados a este esquema. En segundo lugar,se analizan los elementos clav…
Study Regarding Process of the Electrical Discharge Machining with Magnetic Activation of the Welded Joints of some Materials High Alloy Steel
2021
The scientific paper presents an extensive research on modeling and optimizing the technological parameters of the process for processing by processing electric discharges with massive electrode with and without magnetic activation. Scientific research is based on real data collected from the process of electrical discharges performed on various samples extracted from areas of welded joints of metal components made of high alloy steel. The processing of experimental data was performed both classically and actively, especially the method of the central factorial experiment composed of orthogonal and rotary. The process parameters that were initially modeled and subsequently optimized were ba…