Extraction of the mismatch negativity elicited by sound duration decrements: A comparison of three procedures

2009

This study focuses on comparison of procedures for extracting the brain event-related potentials (ERPs) - brain responses to stimuli recorded using electroencephalography (EEG). These responses are used to study how the synchronization of brain electrical responses is associated with cognition such as how the brain detects changes in the auditory world. One such event-related response to auditory change is called mismatch negativity (MMN). It is typically observed by computing a difference wave between ERPs elicited by a frequently repeated sound and ERPs elicited by an infrequently occurring sound which differs from the repeated sounds. Fast and reliable extraction of the ERPs, such as the…

Early motor development and later language and reading skills in children at risk of familial dyslexia.

2005

Relationships between early motor development and language and reading skills were studied in 154 children, of whom 75 had familial risk of dyslexia (37 females, 38 males; at-risk group) and 79 constituted a control group (32 females, 47 males). Motor development was assessed by a structured parental questionnaire during the child's first year of life. Vocabulary and inflectional morphology skills were used as early indicators of language skills at 3 years 6 months and 5 years or 5 years 6 months of age, and reading speed was used as a later indicator of reading skills at 7 years of age. The same subgroups as in our earlier study (in which the cluster analysis was described) were used in th…

Bayesian Modelling of Confusability of Phoneme-Grapheme Connections

2007

Deficiencies in the ability to map letters to sounds are currently considered to be the most likely early signs of dyslexia. This has motivated the use of Literate, a computer game for training this skill, in several Finnish schools and households as a tool in the early prevention of reading disability. In this paper, we present a Bayesian model that uses a student's performance in a game like Literate to infer which phoneme-grapheme connections student currently confuses with each other. This information can be used to adapt the game to a particular student's skills as well as to provide information about the student's learning progress to their parents and teachers. We apply our model to …

Event-Related Potentials and Autonomic Responses to a Change in Unattended Auditory Stimuli

1992

Event-related brain potentials (ERPs) and autonomic nervous system (ANS) responses to occasional pitch and rise-time changes in a task-irrelevant auditory stimulus repeating at short intervals were measured while the subject performed a difficult intellectual task (Raven Matrices). It was found that deviant stimuli elicited the mismatch negativity (MMN) component of the ERP even when they elicited no ANS response. There was no significant difference in the mismatch negativity between trials in which the skin conductance response was or was not elicited. The pitch deviant tone also elicited heart rate deceleration, whereas the rise-time deviant tone tended to elicit a later heart rate accele…

Practice effects on visuomotor and problem-solving tests by children.

2001

Practice effects on a visuomotor test (the Developmental Test of Visuo-Motor Integration), a timed visual discrimination test (the Underlining Test), and two problem-solving tests (the Porteus Mazes Test and the Tower of Hanoi Test) were analyzed. Children of two age groups ( Ms: 7.7 and 11.6 yr.) were chosen to study the effect of age on practice effects. The tests were repeated nine times with test-retest intervals of 2 mo. The Developmental Test of Visuo-Motor Integration showed no practice effects, while the Porteus Mazes Test, the Underlining Test, and the Tower of Hanoi Test showed significant practice effects. Practice effects were larger for the older age group on all the tests, ex…

The GraphoGame Method: The Theoretical and Methodological Background of the Technology-Enhanced Learning Environment for Learning to Read

2014

This paper provides an overview of the GraphoGame method. Both theoretical and methodological aspects related to the method are presented. The method’s guiding principles are based on the prevailing theories and experimental research findings on learning and teaching basic reading skills in alphabetic languages, especially from the point of view of a struggling reader. Because the nature of the target language and its relation to its writing system play central roles in the GraphoGame method, this approach requires the method to be flexible in order to be valid for learners of different languages and orthographies. Thus, the aim of the developed technology is to provide an appropriate readi…

Short-Term Adaptation to Stress and Task-Demands: Covariation of Psychological and Physiological Manifestations

1986

Energetic aspects of adaptation to stress and task demands are reflected in autonomic and somatic nervous system (ANS/SNS) changes (see, eg Lyytinen, 1985). Related psychophysiological individual differences have been illustrated widely in the literature. The reported differences have varied from constitutional ones, like temperament (see, for recent references Nebylitsyn, 1972; Strelau, 1983), via dispositions/traits (Eysenck, 1983) and tonic states (Fahrenberg, Walschburger, Forster, Myrtek and Muller, 1983) to situation-dependent individual differences (eg research on type A; Contrada, Wright and Glass, 1984). The present paper argues that experimential and situational factors are import…

Maturational effects on newborn ERPs measured in the mismatch negativity paradigm.

2003

Abstract The mismatch negativity (MMN) component of event-related potentials (ERPs), a measure of passive change detection, is suggested to develop early in comparison to other ERP components, and an MMN-like response has been measured even from preterm infants. The MMN response in adults is negative in polarity at about 150–200 ms. However, the response measured in a typical MMN paradigm can also be markedly different in newborns, even opposite in polarity. This has been suggested to be related to maturational factors. To verify that suggestion, we measured ERPs of 21 newborns during quiet sleep to rarely occurring deviant tones of 1100 Hz (probability 12%) embedded among repeated standard…

Dyslexia—Early Identification and Prevention: Highlights from the Jyväskylä Longitudinal Study of Dyslexia

2015

Over two decades of Finnish research, monitoring children born with risk for dyslexia has been carried out in the Jyvaskyla Longitudinal Study of Dyslexia (JLD). Two hundred children, half at risk, have been assessed from birth to puberty on hundreds of measures. The aims were to identify measures of prediction of later reading difficulty and to instigate appropriate and earliest diagnosis and intervention. We can identify at-risk children from newborn electroencephalographic brain recordings (Guttorm et al., J Neural Transm 110:1059–1074, 2003). Predictors are also apparent from late-talking infants who have familial background of dyslexia (Lyytinen and Lyytinen, Appl Psycolinguistics 25:3…

Extraction of ERP from EEG data

2007

In this article, a simple but novel technique for extracting a linear subspace related to event related potentials (ERPs) from ElectroEncephaloGraphy (EEG) data is introduced. The technique consists of a sequence of basic linear operations applied to multidimensional EEG data in a problem-specific manner. The derivation of the proposed technique is given and results with real data are described together with overall conclusions.

Parental Literacy Predicts Children's Literacy: A Longitudinal Family-Risk Study

2011

This family-risk (FR) study examined whether the literacy skills of parents with dyslexia are predictive of the literacy skills of their offspring. We report data from 31 child-parent dyads where both had dyslexia (FR-D) and 68 dyads where the child did not have dyslexia (FR-ND). Findings supported the differences in liability of FR children with and without dyslexia: the parents of the FR-D children had more severe difficulties in pseudoword reading and spelling accuracy, in rapid word recognition, and in text reading fluency than the parents of the FR-ND children. Finally, parental skills were found to be significant predictors of children's Grade 3 reading and spelling. Parental skills p…

Fine mapping of the 2p11 dyslexia locus and exclusion of TACR1 as a candidate gene.

2003

Developmental dyslexia, or reading disability, is a multigenic complex disease for which at least five loci, i.e. DYX1-3 and DYX5-6, have been clearly identified from the human genome. To date, DYX1C1 is the only dyslexia candidate gene cloned. We have previously reported linkage to 2p11 and 7q32 in 11 Finnish pedigrees. Here, we report the fine mapping of the approximately 40-cM linked region from chromosome 2 as we increased marker density to one per 1.8 cM. Linkage was supported with the highest NPL score of 3.0 (P=0.001) for marker D2S2216. Association analysis using the six pedigrees showing linkage pointed to marker D2S286/rs3220265 (P value0.001) in the near vicinity of D2S2216. We w…

Examining the Double-Deficit Hypothesis in an Orthographically Consistent Language

2012

We examined the double-deficit hypothesis in Finnish. One hundred five Finnish children with high familial risk for dyslexia and 90 children with low family risk were followed from the age of 3½ years until Grade 3. Children's phonological awareness, rapid naming speed, text reading, and spelling were assessed. A deficit in rapid automatized naming (RAN) predicted slow reading speed across time and spelling difficulties after Grade 1. A deficit in phonological awareness predicted difficulties in spelling, but only in the familial risk sample. The effect of familial risk was significant in the development of phonological awareness, RAN, reading, and spelling. Our findings suggest that the ba…

Classifying Healthy Children and Children with Attention Deficit through Features Derived from Sparse and Nonnegative Tensor Factorization Using Even…

2010

In this study, we use features extracted by Nonnegative Tensor Factorization (NTF) from event-related potentials (ERPs) to discriminate healthy children and children with attention deficit (AD). The peak amplitude of an ERP has been extensively used to discriminate different groups of subjects for the clinical research. However, such discriminations sometimes fail because the peak amplitude may vary severely with the increased number of subjects and wider range of ages and it can be easily affected by many factors. This study formulates a framework, using NTF to extract features of the evoked brain activities from time-frequency represented ERPs. Through using the estimated features of a ne…

Children's engagement during digital game-based learning of reading: The effects of time, rewards, and challenge

2014

This study investigated the effects of two game features (the level of challenge and the reward system) on first and second graders' engagement during digital game-based learning of reading. We were particularly interested in determining how well these features managed to maintain children's engagement over the 8-week training period. The children (N = 138) used GraphoGame, a web-based game training letter-sound connections, at home under the supervision of parents. Data regarding the children's gaming and engagement were stored on the GraphoGame online server. A 2 x 2 factorial design was used to investigate the effects of the level of challenge (high challenge vs. high success) and the pr…

Event‐related brain potentials to change in rapidly presented acoustic stimuli in newborns

1997

Event-related brain potentials of 28 newborns to pitch change were studied during quiet sleep under stimulus conditions that typically elicit mismatch negativity in adults. Rarely occurring deviant tones of 1100 Hz (probability 12%) were embedded among repeated standard tones of 1000 Hz in an oddball-sequence with an interstimulus interval of 425 ms. Two control conditions were also employed: In the first, the 1100-Hz stimulus was presented alone without the intervening standard stimuli, and in the second the deviant stimulus had a pitch of 1300 Hz. In all conditions the infrequent stimulus elicited in most newborns a slow positive deflection peaking at a latency of 250-350 ms. The response…

Evgeny Nikolaevich Sokolov (1920-2008).

2008

Brain reacts to occasional changes in duration of elements in a continuous sound

1995

In order to study the event-related potential correlates of human ability to detect temporal changes within a continuous sound a sound consisting of two alternating pitches of the same constant duration, with infrequent shortenings of one of the tones, was presented to the subjects. The infrequent shortenings were found to elicit a negative component of the auditory event related potential, called the mismatch negativity (MMN). The experimental parameters were chosen to produce a MMN with a minimal contamination of N1, the main negative deflection of an evoked response with the same latency range as MMN and with a short experimental time. The duration of the whole experiment with three diff…

In search of a science-based application: A learning tool for reading acquisition

2009

This is a story about the fate of a psychological application: from its conception to the optimistic vision surrounding its future. We hope that this application - an enjoyable learning game (www or mobile phone-based, available free of charge to the end users) for children - can at best help millions of children in their reading acquisition in the future. Its basis was created by following intensively the development of children with (N = 107) and without (N = 92) genetic (familial) risk for dyslexia from birth to puberty in the Jyväskylä Longitudinal study of Dyslexia (JLD)-project. We summarize some of the major findings of the JLD in order to facilitate understanding of the reasons and …

Hilbert-Huang versus Morlet wavelet transformation on mismatch negativity of children in uninterrupted sound paradigm

2008

Background Compared to the waveform or spectrum analysis of event-related potentials (ERPs), time-frequency representation (TFR) has the advantage of revealing the ERPs time and frequency domain information simultaneously. As the human brain could be modeled as a complicated nonlinear system, it is interesting from the view of psychological knowledge to study the performance of the nonlinear and linear time-frequency representation methods for ERP research. In this study Hilbert-Huang transformation (HHT) and Morlet wavelet transformation (MWT) were performed on mismatch negativity (MMN) of children. Participants were 102 children aged 8–16 years. MMN was elicited in a passive oddball parad…

Extract Mismatch Negativity and P3a through Two-Dimensional Nonnegative Decomposition on Time-Frequency Represented Event-Related Potentials

2010

This study compares the row-wise unfolding nonnegative tensor factorization (NTF) and the standard nonnegative matrix factorization (NMF) in extracting time-frequency represented event-related potentials—mismatch negativity (MMN) and P3a from EEG under the two-dimensional decomposition The criterion to judge performance of NMF and NTF is based on psychology knowledge of MMN and P3a MMN is elicited by an oddball paradigm and may be proportionally modulated by the attention So, participants are usually instructed to ignore the stimuli However the deviant stimulus inevitably attracts some attention of the participant towards the stimuli Thus, P3a often follows MMN As a result, if P3a was large…

Perception of phonemic length and its relation to reading and spelling skills in children with family risk for dyslexia in the first three grades of …

2010

Purpose To examine the ability to discriminate phonemic length and the association of this ability with reading accuracy, reading speed, and spelling accuracy in Finnish children throughout Grades 1–3. Method Reading-disabled (RDFR, n = 35) and typically reading children (TRFR, n = 69) with family risk for dyslexia and typically reading control children (TRC, n = 80) were tested once in each grade of Grades 1–3 using a phonemic length discrimination task. Reading, spelling, IQ, verbal short-term memory, phonological memory, and naming speed were assessed. Results The RDFR group made more errors in phonemic length discrimination than the TRC group in Grades 2 and 3. After taking into accoun…

Brain event-related potentials (ERPs) measured at birth predict later language development in children with and without familial risk for dyslexia.

2005

We report associations between brain event-related potentials (ERPs) measured from newborns with and without familial risk for dyslexia and these same children's later language and verbal memory skills at 2.5, 3.5, and 5 years of age. ERPs to synthetic consonant-vowel syllables (/ba/, /da/, /ga/; presented equiprobably with 3,910-7,285 msec interstimulus intervals) were recorded from 26 newborns at risk for familial dyslexia and 23 control infants participating in the Jyvaskyla Longitudinal Study of Dyslexia. The correlation and regression analyses showed that the at-risk type of response pattern at birth (a slower shift in polarity from positivity to negativity in responses to /ga/ at 540-…

Validating rationale of group-level component analysis based on estimating number of sources in EEG through model order selection

2012

This study addresses how to validate the rationale of group component analysis (CA) for blind source separation through estimating the number of sources in each individual EEG dataset via model order selection. Control children, typically reading children with risk for reading disability (RD), and children with RD participated in the experiment. Passive oddball paradigm was used for eliciting mismatch negativity during EEG data collection. Data were cleaned by two digital filters with pass bands of 1-30 Hz and 1-15 Hz and a wavelet filter with the pass band narrower than 1-12 Hz. Three model order selection methods were used to estimate the number of sources in each filtered EEG dataset. Un…

Mismatch negativity (MMN) elicited by duration deviations in children with reading disorder, attention deficit or both.

2007

According to several studies auditory discrimination as measured by mismatch negativity (MMN) is compromised in participants with reading disorder. However, studies on duration discrimination have produced conflicting findings [Baldeweg, T., Richardson, A., Watkins, S., Foale, C., & Gruzelier, J., 1999. Impaired auditory frequency discrimination in dyslexia detected with mismatch evoked potentials. Annals of Neurology, 4, 1-9; Corbera, S., Escera, C., & Artigas, J., 2006. Impaired duration mismatch negativity in developmental dyslexia. Neuroreport, 17, 1051-1055]. Auditory sensitivity has not been as actively investigated among children with attention deficit, although attention problems of…

Support Systems for Poor Readers: Empirical Data From Six EU Member States

2011

International audience; This study surveyed and compared support systems for poor readers in six member states of the European Union (EU). The goal was to identify features of effective support systems. A large-scale questionnaire survey was conducted among mainstream teachers (n = 4,210) and remedial teachers (n = 2,395). Results indicate that the six support systems differed substantially, with effective support systems showing high performance on all variables measured. More specifically, effective support systems were characterized by (a) high levels of both teacher and student support and (b) frequent interactions between teachers and remedial teachers as well as between remedial teach…

Is School a Better Environment Than Home for Digital Game-Based Learning? The Case of GraphoGame

2015

This study investigated how the use of an online reading game differs in home and school environments. First and second graders (N = 194) participated in an 8-week training during which they used the reading program GraphoGame either at home or at school under the supervision of parents or teachers. Child participants were recommended by parents and teachers recruited from the list of GraphoGame users, and adults decided whether the training took place at home or at school. We measured the frequency and duration of playing, children’s engagement, development of reading skill and reading interest, and adult supportive involvement. The results revealed that children who played GraphoGame at s…

Literacy programs efficacy for developing children’s early reading skills in familiar language in Zambia

2018

This study investigated the comparative efficacy of a phonics-based reading program and a language experience approach based literacy program to develop reading skills among Zambian early childhood school learners. The learners (n = 1 986; Grade 2 level; females = 50.1%) took either the phonics-based reading program (n = 1 593) or the alternative language experience approach based program (n = 393). They were all assessed for reading skills utilising the Early Grade Reading Assessment test (EGRA) in four languages (Cinyanja, Icibemba, Kiikaonde, and Silozi). Results suggest that learners in phonics-based literacy program were significantly better in letter-sound knowledge in all the four la…

Unveiling the Mysteries of Dyslexia-Lessons Learned from the Prospective Jyväskylä Longitudinal Study of Dyslexia.

2021

This paper reviews the observations of the Jyväskylä Longitudinal Study of Dyslexia (JLD). The JLD is a prospective family risk study in which the development of children with familial risk for dyslexia (N = 108) due to parental dyslexia and controls without dyslexia risk (N = 92) were followed from birth to adulthood. The JLD revealed that the likelihood of at-risk children performing poorly in reading and spelling tasks was fourfold compared to the controls. Auditory insensitivity of newborns observed during the first week of life using brain event-related potentials (ERPs) was shown to be the first precursor of dyslexia. ERPs measured at six months of age related to phoneme length identi…

Preparation, Execution and Experience: A Multivariate Evaluation of ANS-SNS Patterns

1985

Aims to verify with multivariate methods how autonomic-somatic changes (composed by skin conductance, heart rate, pulse amplitude, respiration, blood volume and flexor, frontal and orbicutaris oris EMG-measures) from specific patterns according to event-related demands both during (or after) and before events when contentual and temporal knowledge allowing preparation is varied.

A genome scan for developmental dyslexia confirms linkage to chromosome 2p11 and suggests a new locus on 7q32

2003

Developmental dyslexia is a distinct learning disability with unexpected difficulty in learning to read despite adequate intelligence, education, and environment, and normal senses. The genetic aetiology of dyslexia is heterogeneous and loci on chromosomes 2, 3, 6, 15, and 18 have been repeatedly linked to it. We have conducted a genome scan with 376 markers in 11 families with 38 dyslexic subjects ascertained in Finland. Linkage of dyslexia to the vicinity of DYX3 on 2p was confirmed with a non-parametric linkage (NPL) score of 2.55 and a lod score of 3.01 for a dominant model, and a novel locus on 7q32 close to the SPCH1 locus was suggested with an NPL score of 2.77. The SPCH1 locus has p…

SINGLE-TRIAL BASED INDEPENDENT COMPONENT ANALYSIS ON MISMATCH NEGATIVITY IN CHILDREN

2010

Independent component analysis (ICA) does not follow the superposition rule. This motivates us to study a negative event-related potential — mismatch negativity (MMN) estimated by the single-trial based ICA (sICA) and averaged trace based ICA (aICA), respectively. To sICA, an optimal digital filter (ODF) was used to remove low-frequency noise. As a result, this study demonstrates that the performance of the sICA+ODF and aICA could be different. Moreover, MMN under sICA+ODF fits better with the theoretical expectation, i.e., larger deviant elicits larger MMN peak amplitude.

N1 and P2 components of auditory event-related potentials in children with and without reading disabilities.

2007

Abstract Objective The effects of within stimulus presentation rate and rise time on basic auditory processing were investigated in children with reading disabilities and typically reading children. Methods Children with reading disabilities (RD; N =19) and control children ( N =20) were studied using event-related potentials (ERPs). Paired stimuli were used with two different within-pair-intervals (WPI; 10 and 255ms) and two different rise times (10 and 130ms). Each stimulus was presented with equal probability and long between-pair inter-stimulus intervals (1–5s). The study focused on N1 and P2 components. Results The P2 responses to the first tone in the pair showed differences between c…

Contextual analysis of home environment factors influencing the acquisition of early reading skills in Zambian families

2014

This study examined the effect of home environment factors in the acquisition of early reading skills (orthographic awareness and decoding competence). To assess these factors, a sample of seventy-two (72) first grade learners (females = 55%; age range = 7–8 years) and their maternal parents (age range 26–61 years old) from low SES in Zambia's capital city, Lusaka were recruited. Parents, in response to a home literacy questionnaire, reported on their attitudes towards reading, literacy teaching in the home, the home literacy environment, presence of reading materials for adults and children, parental education, occupation, family size and family possessions. Two measures of reading skill w…

Predicting Delay in Reading Achievement in a Highly Transparent Language

2004

A random sample of 91 preschool children was assessed prior to receiving formal reading instruction. Verbal and nonverbal measures were used as predictors for the time of instruction required to accurately decode pseudowords in the highly orthographically regular Finnish language. After 2 years, participants were divided into four groups depending on the duration of instruction they had required to reach 90 % accuracy in their reading of pseudowords. Participants were classified as precocious decoders (PD), who could read at school entry; early decoders (ED), who learned to read within the first 4 months of Grade 1; ordinary decoders (OD), who learned to read within 9 months; and late deco…

Reading skill and neural processing accuracy improvement after a 3-hour intervention in preschoolers with difficulties in reading-related skills

2012

This study aimed at determining whether an intervention game developed for strengthening phonological awareness has a remediating effect on reading skills and central auditory processing in 6-year-old preschool children with difficulties in reading-related skills. After a 3-hour training only, these children made a greater progress in reading-related skills than did their matched controls who did mathematical exercises following comparable training format. Furthermore, the results suggest that this brief intervention might be beneficial in modulating the neural basis of phonetic discrimination as an enhanced speech-elicited mismatch negativity (MMN) was seen in the intervention group, indic…

Literacy Skill Development of Children With Familial Risk for Dyslexia Through Grades 2, 3, and 8

2015

This study followed the development of reading speed, reading accuracy, and spelling in transparent Finnish orthography in children through Grades 2, 3, and 8. We compared 2 groups of children with familial risk for dyslexia—1 group with dyslexia (Dys_FR, n = 35) and 1 group without (NoDys_FR, n = 66) in Grade 2—with a group of children without familial risk for dyslexia (controls, n = 72). The Dys_FR group showed persistent deficiency, especially in reading speed, and, to a minor extent, in reading and spelling accuracy. The Dys_FR children, contrary to the other 2 groups, relied heavily on letter-by-letter decoding in Grades 2 and 3. In children not fulfilling the criteria for dyslexia in…

Brain sensitivity to print emerges when children learn letter–speech sound correspondences

2010

The acquisition of reading skills is a major landmark process in a human's cognitive development. On the neural level, a new functional network develops during this time, as children typically learn to associate the well-known sounds of their spoken language with unfamiliar characters in alphabetic languages and finally access the meaning of written words, allowing for later reading. A critical component of the mature reading network located in the left occipito-temporal cortex, termed the “visual word-form system” (VWFS), exhibits print-sensitive activation in readers. When and how the sensitivity of the VWFS to print comes about remains an open question. In this study, we demonstrate the…

Empirical Mode Decomposition on Mismatch Negativity

2008

Empirical mode decomposition (EMD) has been applied in the various disciplines to extract the desired signal. The basic principle is to decompose a time series into intrinsic mode functions (IFMs) and each IFM corresponds to an oscillation phenomenon. A statistical description of the oscillatory activities of the EEG has been well known. It is desired to extract single oscillatory process from the EEG by EMD. Mismatch negativity (MMN) can be automatically elicited by the deviant stimulus in an oddball paradigm, in which physically the deviant stimulus occurs among repetitive and homogeneous stimuli. MMN thus reflects the ability of the brain to detect changes in auditory stimuli. So, the MM…

Language development, literacy skills and predictive connections to reading in Finnish children with and without familial risk for dyslexia

2010

Discriminative language markers and predictive links between early language and literacy skills were investigated retrospectively in the Jyväskylä Longitudinal Study of Dyslexia in which children at familial risk for dyslexia have been followed from birth. Three groups were formed on the basis of 198 children’s reading and spelling status. One group of children with reading disability (RD; n = 46) and two groups of typical readers from nondyslexic control (TRC; n = 84) and dyslexic families (TRD; n = 68) were examined from age 1.5 years to school age. The RD group was outperformed by typical readers on numerous language and literacy measures (expressive and receptive language, morphology, …

GraphoLearn India : The Effectiveness of a Computer-Assisted Reading Intervention in Supporting Struggling Readers of English

2018

India, a country with a population of more than 1.3 billion individuals, houses the world’s second largest educational system. Despite this, 100 of millions of individuals in India are still illiterate. As English medium education sweeps the country, many are forced to learn in a language which is foreign to them. Those living in poverty further struggle to learn English as it tends to be a language which they have no prior exposure to and no support at home for. Low-quality schools and poor instructional methods further exacerbate the problem. Without access to quality education, these individuals continue to struggle and are ultimately never given the chance to break the cycle of poverty.…

Modeling the Early Paths of Phonological Awareness and Factors Supporting its Development in Children With and Without Familial Risk of Dyslexia

2007

The development of phonological awareness (PA) before school age was modeled in association with the development of vocabulary and letter knowledge, home literacy environment (HLE), children's reading interest, and beginning reading skill in children with and without familial risk of dyslexia. A total of 186 children were followed from birth to the age of 6.5 years. Of these children, about half had a familial background of reading difficulties (the at-risk group), and the other half came from families without such background (the control group). The data from several measures and assessment time points were analyzed within an SEM framework, and a latent analysis of growth curves was employ…

An electrophysiological study of print processing in kindergarten: the contribution of the visual n1 as a predictor of reading outcome.

2013

Sensitivity to print is characterized by a left occipito-temporal negativity to words in the event-related potential N1. This sensitivity is modulated by reading skills and may thus represent a neural marker of reading competence. Here we studied the development of the N1 in regular and poor readers from preschool age to school age to test whether the amplitude of the N1 predicts children's reading outcomes. Our results suggest a predictive value of the print-sensitive negativity over the right hemisphere. Whether this N1 may serve as a biomarker to improve prognosis in preliterate children should be clarified in future studies.

Shot placement within cardiac cycle in junior elite rifle shooters

2007

Abstract Objectives This study examined the timing of the trigger pull in relation to the cardiac cycle during skilled precision shooting. Methods Electrocardiogram was recorded from 20 junior level competitive air-rifle shooters in two separate sessions. The testing was conducted at an indoor shooting range using an optoelectronic shooting system. The experimental task was to fire a shot in the standing position at a distance of 10 m from the target. Results The results showed that the junior level shooters fired more often during the phase of 10–15% of the R wave-to-R wave (R–R) interval. With regards to the accuracy of performance, there was not any optimal location for triggering in the…

Event-related potentials to pitch and rise time change in children with reading disabilities and typically reading children.

2008

Abstract Objective The purpose of the present study was to investigate whether children with reading disabilities (RD) process rise time and pitch changes differently to control children as a function of the interval between two tones. Methods Children participated in passive oddball event-related potential (ERP) measurements using paired stimuli. Mismatch negativity (MMN), P3a and late discriminative negativity (LDN) responses to rise time and pitch changes were examined. Results Control children produced larger responses than children with RD to pitch change in the P3a component but only when the sounds in the pair were close to each other. Compared to children with RD, MMN was smaller an…

Detection of sound rise time by adults with dyslexia

2005

Low sensitivity to amplitude modulated (AM) sounds is reported to be associated with dyslexia. An important aspect of amplitude modulation cycles are the rise and fall times within the sound. In this study, simplified stimuli equivalent to just one cycle were used and sensitivity to varying rise times was explored. Adult participants with dyslexia or compensated dyslexia and a control group performed a detection task with sound pairs of different rise times. Results showed that the participants with dyslexia differed from the control group in rise time detection and a correlation was found between rise time detection and reading and phonological skills. A subgroup of participants with lower…

Predicting Reading Disability: Early Cognitive Risk and Protective Factors

2013

This longitudinal study examined early cognitive risk and protective factors for Grade 2 reading disability (RD). We first examined the reading outcome of 198 children in four developmental cognitive subgroups that were identified in our previous analysis: dysfluent trajectory, declining trajectory, unexpected trajectory and typical trajectory. We found that RD was unevenly distributed among the subgroups, although children with RD were found in all subgroups. A majority of the children with RD had familial risk for dyslexia. Second, we examined in what respect children with similar early cognitive development but different RD outcome differ from each other in cognitive skills, task-focused…

Identical fits of nonnegative matrix/tensor factorization may correspond to different extracted event-related potentials

2010

Nonnegative Matrix / Tensor factorization (NMF/NTF) have been used in the study of EEG, and the fit (explained variation) is often used to evaluate the performance of a nonnegative decomposition algorithm. However, this parameter only reveals the information derived from the mathematical model and just exhibits the reliability of the algorithms, and the property of EEG can not be reflected. If fits of two algorithms are identical, it is necessary to examine whether the desired components extracted by them are identical too. In order to verify this doubt, we performed NMF and NTF on the same dataset of an auditory event-related potentials (ERPs), and found that the identical fits of NMF and …

The effect of using a mobile literacy game to improve literacy levels of grade one students in Zambian schools

2014

This intervention study was conducted to document conditions under which a computer based literacy game (GraphoGame™) could enhance literacy skills of first grade students in an African city. The participants were first grade students from Government schools (N = 573). These students were randomly sampled into control (N = 314) and various intervention groups (N = 259). GraphoGame™ was administered on cellphones to students at their schools under supervision. Each student in the study was assessed using a battery of locally developed cognitive tests that measured emergent literacy skills (Orthography test), decoding competence (Spelling test), vocabulary (Picture Vocabulary Test—PVT) and ar…

Predictors of developmental dyslexia in European orthographies with varying complexity

2012

Background: The relationship between phoneme awareness, rapid automatized naming (RAN), verbal short-term/working memory (ST/WM) and diagnostic category is investigated in control and dyslexic children, and the extent to which this depends on orthographic complexity. Methods: General cognitive, phonological and literacy skills were tested in 1,138 control and 1,114 dyslexic children speaking six different languages spanning a large range of orthographic complexity (Finnish, Hungarian, German, Dutch, French, English). Results: Phoneme deletion and RAN were strong concurrent predictors of developmental dyslexia, while verbal ST/WM and general verbal abilities played a comparatively minor role…

Newborn brain event-related potentials revealing atypical processing of sound frequency and the subsequent association with later literacy skills in …

2010

The role played by an auditory-processing deficit in dyslexia has been debated for several decades. In a longitudinal study using brain event-related potentials (ERPs) we investigated 1) whether dyslexic children with familial risk background would show atypical pitch processing from birth and 2) how these newborn ERPs later relate to these same children's pre-reading cognitive skills and literacy outcomes. Auditory ERPs were measured at birth for tones varying in pitch and presented in an oddball paradigm (1100 Hz, 12%, and 1000 Hz, 88%). The brain responses of the typically reading control group children (TRC group, N=25) showed clear differentiation between the frequencies, while those o…

Auditory event-related potentials measured in kindergarten predict later reading problems at school age.

2013

Identifying children at risk for reading problems or dyslexia at kindergarten age could improve support for beginning readers. Brain event-related potentials (ERPs) were measured for temporally complex pseudowords and corresponding non-speech stimuli from 6.5-year-old children who participated in behavioral literacy tests again at 9 years in the second grade. Children who had reading problems at school age had larger N250 responses to speech and non-speech stimuli particularly at the left hemisphere. The brain responses also correlated with reading skills. The results suggest that atypical auditory and speech processing are a neural-level risk factor for future reading problems. [Supplement…

Repeated assessment of the Tower of Hanoi test: reliability and age effects.

2000

The purpose of this research was to analyze the effects of repeating an executive function test. Three versions of the Tower of Hanoi (TOH) test were repeated three times each, with test-retest intervals of 2 months. Two groups of children participated in the research (7.7 and 11.6 years, n = 22 and n = 28). Repeating the assessment improved the performance and decreased the total performance time in both of the groups. The older participants improved their performance faster than the younger ones. The reliability of all the scores, besides the error scores, seemed to be satisfactory after the first few assessments. The stability of the scores was maintained through all the assessments. Th…

Paired associate learning tasks and their contribution to reading skills

2016

Associative learning has been identified as one of several non-linguistic processes involved in reading acquisition. However, it has not been established whether it is an independent process that contributes to reading performance on its own or whether it is a process that is embedded in other linguistic skills (e.g., phonological awareness or phonological memory) and, therefore, contributing to reading performance indirectly. Research has shown that performance on tasks assessing associative learning, e.g., paired-associate learning (PAL) tasks, is lower in children with specific reading difficulties compared to typical readers. We explored the differential associations of two distinct ver…

Cracking the Code : The Impact of Orthographic Transparency and Morphological-Syllabic Complexity on Reading and Developmental Dyslexia

2019

Reading is an essential skill in modern societies, yet not all learners necessarily become proficient readers. Theoretical concepts (e.g., the orthographic depth hypothesis; the grain size theory) as well as empirical evidence suggest that certain orthographies are easier to learn than others. The present paper reviews the literature on orthographic transparency, morphological complexity, and syllabic complexity of alphabetic languages. These notions are elaborated to show that differences in reading acquisition reflect fundamental differences in the nature of the phonological recoding and reading strategies developing in response to the specific orthography to be learned. The present paper…

E-wave and heart rate responses during anticipation of nonmotor events.

1994

This study concentrated on three main questions: 1) can anticipatory late negative shift (expectancy wave, E-wave) be elicited in nonmotor S1-S2 paradigm, 2) is it sensitive to variation of emotional aspects of the task and 3) is there a connection between heart rate (HR) responses and E-wave. S1 was a letter row that was replaced tachistoscopically by another letter row (S2). The task of the subjects (n = 12) was to detect if the critical aspects of S2 were similar to S1. After their delayed response they received feedback of their performance. The emotional aspects of the task were varied by presenting aversive noise bursts at the end of the feedback period either always, contingently to …

Longitudinal interactions between brain and cognitive measures on reading development from 6 months to 14 years

2017

Dyslexia is a neurobiological disorder impairing learning to read. Brain responses of infants at genetic risk for dyslexia are abnormal already at birth, and associations from infant speech perception to preschool cognitive skills and reading in early school years have been documented, but there are no studies showing predicting power until adolescence. Here we show that in at-risk infants, brain activation to pseudowords at left hemisphere predicts 44% of reading speed at 14 years, and even improves the prediction after taking into account neurocognitive preschool measures of letter naming, phonology, and verbal short-term memory. The association between infant brain responses and reading …

Event-Related Potentials and Consonant Differentiation in Newborns with Familial Risk for Dyslexia

2004

We measured event-related potentials (ERPs) to synthetic consonant-vowel syllables (/ba/, /da/, /ga/) from 26 newborns with familial risk for dyslexia and 23 control infants participating in the Jyväskylä Longitudinal Study of Dyslexia. The syllables were presented with equal probability and with interstimulus intervals ranging from 3,010 to 7,285 ms. Analyses of averaged ERPs from the latencies identified on the basis of principal component analysis (PCA) revealed significant group differences in stop-consonant processing in several latency ranges. At the latencies of 50-170 ms and 540-630 ms, the responses to /ga/ were larger and more positive than those to /ba/ and /da/ in the right hem…

Autonomic and cortical responses during anticipation of a sensory task and of feedback from task results

1991

Cognitive mechanisms underlying reading and spelling development in five European orthographies

2014

This paper addresses the question whether the cognitive underpinnings of reading and spelling are universal or language/orthography-specific. We analyzed concurrent predictions of phonological processing (awareness and memory) and rapid automatized naming (RAN) for literacy development in a

Auditory event-related potentials show altered hemispheric responses in dyslexia

2011

Dyslexia is characterized by deficits in phonological processing abilities. However, it is unclear what the underlying factors for poor phonological abilities or speech sound representations are. One hypothesis suggests that individuals with dyslexia have problems in basic acoustic perception which in turn can also cause problems in speech perception. Here basic auditory processing was assessed by auditory event-related potentials recorded for paired tones presented in an oddball paradigm in 9-year-old children with dyslexia and a familial background of dyslexia, typically reading children at familial risk for dyslexia and control children without risk for dyslexia. The tone pairs elicited …

Effects of Multidomain Risk Accumulation on Cognitive, Academic, and Behavioural Outcomes

2009

This longitudinal study examined the predictive associations between cumulative multidomain risk factors and cognitive (IQ), academic (reading fluency), and social adaptive outcomes at 8 to 9 years among 190 children with or without familial risk for dyslexia. Other risk factors included parental and neurocognitive risks assessed when the children were 1 to 6 years of age. Risks accumulated more among children with familial risk for dyslexia than among children without familial risk. A higher number of risks was associated with poorer performance in all outcome measures as postulated by the cumulative risk model. However, when the effects of individual risk variables were controlled for at …

Measuring orthographic transparency and morphological-syllabic complexity in alphabetic orthographies

2017

This narrative review discusses quantitative indices measuring differences between alphabetic languages that are related to the process of word recognition. The specific orthography that a child is acquiring has been identified as a central element influencing reading acquisition and dyslexia. However, the development of reliable metrics to measure differences between language scripts hasn’t received much attention so far. This paper therefore reviews metrics proposed in the literature for quantifying orthographic transparency, syllabic complexity, and morphological complexity of alphabetic languages. The review included searches of Web of Science, PubMed, PsychInfo, Google Scholar, and var…

Brain Slow Potentials and Postural Sway Behavior During Sharpshooting Performance.

1999

In the present study, the relation of preparatory brain slow potentials (SPs) to postural body sway during sharpshooting performance was examined. SPs from frontal, left-central, and right-central areas were recorded from 6 elite and 6 non-elite sharpshooters during a realistic simulated shooting task. A force platform technique was used in the recording of postural sway. The results showed that body sway, as indexed by sway amplitude and mean velocity, was associated with the concomitant SP changes. That relationship was dependent on the shooter's expertise level, however. The main finding among the elite shooters was that the reduced amplitude of body sway coincided with reduced frontal p…

Brain responses to changes in speech sound durations differ between infants with and without familial risk for dyslexia

2002

A specific learning disability, developmental dyslexia, is a language-based disorder that is shown to be strongly familial. Therefore, infants born to families with a history of the disorder are at an elevated risk for the disorder. However, little is known of the potential early markers of dyslexia. Here we report differences between 6-month-old infants with and without high risk of familial dyslexia in brain electrical activation generated by changes in the temporal structure of speech sounds, a critical cueing feature in speech. We measured event-related brain responses to consonant duration changes embedded in ata pseudowords applying an oddball paradigm, in which pseudoword tokens with…

Suggestions for revised scoring of the Tower of Hanoi test

2000

Detailed time and error analyses of the Tower of Hanoi (TOH) test was performed using four repeated assessments of eight children (ages 9-12 years), who had perceptual and problem solving deficits. The time before each move was measured. In addition to the traditionally counted time scores, new, relative time scores were computed in order to separate the planning time from the general reaction speed. New error scores were defined and sum scores of serious errors (perserative moves, illegal moves, and wrong results) and mild errors (self-corrected moves, almost performed moves, and interrupted trials) were computed. The relative planning time correlated positively with the achieved score, a…

Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia

2019

Developmental dyslexia (DD) is one of the most prevalent learning disorders, with high impact on school and psychosocial development and high comorbidity with conditions like attention-deficit hyperactivity disorder (ADHD), depression, and anxiety. DD is characterized by deficits in different cognitive skills, including word reading, spelling, rapid naming, and phonology. To investigate the genetic basis of DD, we conducted a genome-wide association study (GWAS) of these skills within one of the largest studies available, including nine cohorts of reading-impaired and typically developing children of European ancestry (N = 2562–3468). We observed a genome-wide significant effect (p < 1 × 10…

Two-year group treatment for children with learning difficulties: assessing effects of treatment duration and pretreatment characteristics.

1997

The results of a 2-year treatment study of children with learning problems are reported. During the first treatment year, half of the children participated in a multifaceted neurocognitive treatment and the other half in a treatment that provided supervision of school tasks and peer group support. During the second treatment year, all children participated in the neurocognitive treatment. The participants were 74 Chilean children 6 to 11 years old. The issues under investigation were the effect of treatment duration, and the relationship between pretreatment neurocognitive and behavioral characteristics and academic treatment outcome. The results indicated that significant gains occurred d…

Attention deficit hyperactivity disorder subtypes: Are there differences in academic problems?

1995

This article addresses the relationship between attention deficit hyperactivity disorder (ADHD) and academic problems. The development of diagnostic categories of attention deficits from the Diagnostic and Statistical Manual of Mental Disorders (3rd ed.) to the Diagnostic and Statistical Manual of Mental Disorders (4th ed.) is briefly reviewed. Forty‐five Chilean children demonstrating symptoms of either ADHD Combined Type, ADHD Predominantly Inattentive Type, or ADHD Predominantly Hyperactivity‐Impulsive Type are compared with each other and with a clinical control group on the prevalence of academic achievement problems. The data show that academic problems are more common among ADHD Comb…

Repeated Reading of Syllables Among Finnish-Speaking Children With Poor Reading Skills

2010

The study evaluated the effect of repeated reading on reading speed among 36 Finnish-speaking poor readers in Grades 4 to 6. A switching replications design was applied: Group A (n = 20) received training first, and during this period Group B (n = 16) acted as a control group. After a midpoint test, the design was switched. The training material consisted of syllables, which were practiced during 10 training sessions for a total of 50 times. The reading speed of the trained syllables increased more during training than during the control period. During training, the reading speed of pseudowords containing the trained syllables improved significantly. This improvement was found both in a com…

Predicting word-level reading fluency outcomes in three contrastive groups: Remedial and computer-assisted remedial reading intervention, and mainstr…

2010

Abstract The aim of the longitudinal intervention study was to build a model of predictive values of reading fluency in three contrastive reading groups: remedial and computer-assisted remedial reading intervention, and mainstream instruction, to identify the most effective type of intervention for children with different profiles of compromised pre-reading skills. The participants were 7-year-old Finnish school beginners ( N  = 166). Two remedial interventions took place in four weekly sessions of 45 min over a period of 28 weeks in Grade 1. For a child with deficits in the core pre-reading skills (letter knowledge, phonological awareness or rapid automatized naming), the computer-assisted…

Non-negative matrix factorization Vs. FastICA on mismatch negativity of children

2009

In this presentation two event-related potentials, mismatch negativity (MMN) and P3a, are extracted from EEG by non-negative matrix factorization (NMF) simultaneously. Typically MMN recordings show a mixture of MMN, P3a, and responses to repeated standard stimuli. NMF may release the source independence assumption and data length limitations required by Fast independent component analysis (FastICA). Thus, in theory NMF could reach better separation of the responses. In the current experiment MMN was elicited by auditory duration deviations in 102 children. NMF was performed on the time-frequency representation of the raw data to estimate sources. Support to Absence Ratio (SAR) of the MMN co…

Automatic and controlled processing of acoustic and phonetic contrasts

2003

Changes in the temporal properties of the speech signal provide important cues for phoneme identification. An impairment or inability to detect such changes may adversely affect one's ability to understand spoken speech. The difference in meaning between the Finnish words tuli (fire) and tuuli (wind), for example, lies in the difference between the duration of the vowel /u/. Detecting changes in the temporal properties of the speech signal, therefore, is critical for distinguishing between phonemes and identifying words. In the current study, we tested whether detection of changes in speech sounds, in native Finnish speakers, would vary as a function of the position within the word that the…

Optimal Digital Filtering versus Difference Waves on the Mismatch Negativity in an Uninterrupted Sound Paradigm

2007

Conventionally, mismatch negativity (MMN) is analyzed through the calculation of the difference waves. This helps to eliminate some exogenous event-related potential (ERP) components. However, this reduces the signal-to-noise ratio (SNR). This study aims to test whether or not the optimal digital filtering performs better than the difference waves procedure in quantitative ERP analyses in an uninterrupted sound paradigm. The participants were 102 children aged 8-16 years. The MMN was elicited in a passive oddball paradigm presenting an uninterrupted sound consisting of two alternating tones (600 and 800 Hz) of the same duration (100 msec) with infrequent shortenings of one of the 600 Hz ton…

Supporting Urgent Basic Reading Skills in Children in Africa and Around the World

2014

Estimation and visualization of confusability matrices from adaptive measurement data

2010

Abstract We present a simple but effective method based on Luce’s choice axiom [Luce, R.D. (1959). Individual choice behavior: A theoretical analysis. New York: John Wiley & Sons] for consistent estimation of the pairwise confusabilities of items in a multiple-choice recognition task with arbitrarily chosen choice-sets. The method combines the exact (non-asymptotic) Bayesian way of assessing uncertainty with the unbiasedness emphasized in the classical frequentist approach. We apply the method to data collected using an adaptive computer game designed for prevention of reading disability. A player’s estimated confusability of phonemes (or more accurately, phoneme–grapheme connections) and l…

Computer-Assisted Remedial Reading Intervention for School Beginners at Risk for Reading Disability

2011

The aim of the longitudinal study was to investigate whether a computer application designed for remedial reading training can enhance letter knowledge, reading accuracy, fluency, and spelling of at-risk children. The participants, 7-year-old Finnish school beginners (N = 166), were assigned to 1 of 3 groups: (a) regular remedial reading intervention (n = 25), (b) computer-assessed reading intervention (n = 25), and (c) mainstream reading instruction (n = 116). Based on the results, computer-assisted remedial reading intervention was highly beneficial, whereas regular type of intervention was less successful. The results indicated that at-risk children require computer-based letter–name and…

The role of letters and syllables in typical and dysfluent reading in a transparent orthography

2012

The role of letters and syllables in typical and dysfluent 2nd grade reading in Finnish, a transparent orthography, was assessed by lexical decision and naming tasks. Typical readers did not show reliable word length effects in lexical decision, suggesting establishment of parallel letter processing. However, there were small effects of word syllable structure in both tasks suggesting the presence of some sublexical processing also. Dysfluent readers showed large word length effects in both tasks indicating decoding at the letterphoneme level. When lexical access was required in a lexical decision task, dyslexics additionally chunked the letters into syllables. Response duration measure rev…

Mismatch negativity during objective and subjective sleepiness.

1997

The mismatch negativity (MMN) and P3 of auditory event-related potentials were studied during subjectively and objectively (physiologically) defined sleepiness under optimal stimulus conditions for MMN elicitation. The MMN and P3 were elicited by either small or large unattended auditory deviants presented to the left ear. The participant's task was to detect either rare auditory targets presented to the right ear or rare changes in the light flashes. Eleven young adults served as participants in a nighttime experiment. The MMN declined especially at Fz and Cz but not so markedly at the right mastoid as either subjective or objective alertness decreased. The amplitude of P3 also decreased d…

Enhancement of brain event-related potentials to speech sounds is associated with compensated reading skills in dyslexic children with familial risk …

2014

Specific reading disability, dyslexia, is a prevalent and heritable disorder impairing reading acquisition characterized by a phonological deficit. However, the underlying mechanism of how the impaired phonological processing mediates resulting dyslexia or reading disabilities remains still unclear. Using ERPs we studied speech sound processing of 30 dyslexic children with familial risk for dyslexia, 51 typically reading children with familial risk for dyslexia, and 58 typically reading control children. We found enhanced brain responses to shortening of a phonemic length in pseudo-words (/at:a/ vs. /ata/) in dyslexic children with familial risk as compared to other groups. The enhanced bra…

Supporting struggling readers with digital game-based learning

2019

This study investigates the effectiveness of a digital game—GraphoLearn (GL)—in supporting second-grade students who have persistent difficulties with acquiring accurate and fluent reading skills. The participants (N = 37) were randomly assigned either to a 6-week intervention including sessions with GL, in addition to school-provided support, or a control group receiving only school-provided support. The intervention took place at the students’ homes and schools under the supervision of their parents and teachers. The results showed that the children who received the GL intervention developed significantly faster in word reading than the control group. Moreover, their reading development w…

Mobile solution for better reading instruction in rural Africa

2015

GraphoGame Teacher Training Service is a mobile-based solution for providing teachers with scientifically validated pedagogical training in literacy instruction. In many African countries teachers currently have insufficient knowledge to teach literacy in local languages and learning materials are scarce, especially for children with learning difficulties. As part of the GraphoWorld network, CAPOLSA/University of Zambia is developing new mobile-based method for providing in-service training for teachers in literacy instruction and assisting children with learning difficulties. GraphoGame Teacher Training Service was piloted in October 2014 in rural Zambia. An orientative workshop was given …

Mothers' Causal Attributions Concerning the Reading Achievement of Their Children With and Without Familial Risk for Dyslexia

2008

The present study analyzed data from the Jyväskylä Longitudinal Study of Dyslexia to investigate the factors to which mothers of children with and without familial risk for dyslexia attribute the causes of their first-grade children's reading achievement. Mothers' causal attributions were assessed three times during their children's first school year. Children's verbal intelligence was assessed at 5 years and their word and nonword reading skills at 6.5 years. The results showed that the higher the word reading skills the children had, the more their mothers attributed their success to ability than to effort. However, if children had familial risk for dyslexia, their mothers' attribution o…

Polymorphisms in DCDC2 and S100B associate with developmental dyslexia

2015

Genetic studies of complex traits have become increasingly successful as progress is made in next-generation sequencing. We aimed at discovering single nucleotide variation present in known and new candidate genes for developmental dyslexia: CYP19A1, DCDC2, DIP2A, DYX1C1, GCFC2 (also known as C2orf3), KIAA0319, MRPL19, PCNT, PRMT2, ROBO1 and S100B. We used next-generation sequencing to identify single-nucleotide polymorphisms in the exons of these 11 genes in pools of 100 DNA samples of Finnish individuals with developmental dyslexia. Subsequent individual genotyping of those 100 individuals, and additional cases and controls from the Finnish and German populations, validated 92 out of 111 …

Spatial weighted averaging for ERP denoising in EEG data

2010

In the present paper we intend to improve the practical accuracy of ERP denoising methods proposed in earlier research by allowing them to take into account possible violations of the underlying assumptions, which often take place in practice. Here we consider ERP denoising approaches operating within the framework of the linear instantaneous mixing model that consist three steps: (1) forward linear transformation, (2) identification of the components related to signal and noise subspaces, (3) inverse transformation during which the components that belong to the noise subspace are disregarded, i.e. dimension reduction in the component space. The separation matrix is found based on problem-s…

Computerized training of the correspondences between phonological and orthographic units

2005

The outcomes of computerized training in the correspondences between phonological and orthographic units are reported. Forty-four Finnish-speaking first-graders with poor pre-reading skills were assigned to one of two groups, intervention or control. The children in the intervention group received computerized training over a 6-week period (mean 170 minutes in total) while the children in the control group received regular reading instruction only. Although the short intervention program produced accelerated growth in letter naming, no differential outcomes emerged between the groups in terms of reading acquisition. The outcomes for the poorest performers on six cognitive-linguistic disadva…

A method for extracting subspace of deterministic sources from EEG data

2008

In this paper, an algorithm for separating linear subspaces of time-locked brain responses and other noise sources in multichannel electroencephalography data is proposed. The search criterion used by method discriminates time-locked brain components and noise components on the basis of the assumed deterministic behavior that the time-locked brain sources obey. The comprehensive derivation of the method is given together with the description and the analysis of the results of the method's application to simulated and real EEG data sets. The possibilities of improving the results are also discussed.

Challenges Associated with Reading Acquisition in Sub-Saharan Africa : Promotion of Literacy in Multilingual Contexts

2019

Heikki Lyytinen and his co-authors note the problems of poorly trained teachers and large class sizes in Africa. Drawing on experience in Zambia, they present a case study of a digital game that can help overcome these problems and lead to more effective literacy instruction, particularly for students facing barriers to learning how to read. peerReviewed

Rifle-balancing in precision shooting:behavioral aspects and psychophysiological implication

2007

This study investigated sharpshooters' strategies to control their rifle stability during the aiming period. Six elite and six pre-elite shooters completed a simulated realistic shooting task (laser rifle), and their performance was evaluated from behavioral and psychophysiological perspectives. The analysis of the rifle's barrel movement, indexing the shooter's behavioral performance, supported the view that rifle-balancing is an essential determinant of superior shooting performance. The psychophysiological data, i.e. the brain slow potentials, suggested that the shooters applied different rifle-hold strategies; the elite shooters concentrated primarily on achieving a stable rifle positio…

Assessing the effectiveness of a game‐based phonics intervention for first and second grade English language learners in India: A randomized controll…

2021

Background In 2018, it was found that only a quarter of Grade 3 children in India were reading at grade level. A growing demand for English education has further limited children's literacy achievement. Despite a strong evidence base in favour of using systematic phonics for building English literacy skills, many teachers in India continue to use rote-methods of literacy instruction. Objectives We aimed to examine the efficacy of GraphoLearn (GL) English Rime, a computer-assisted reading intervention, in improving the foundational literacy skills of 1st and 2nd grade students who were attending an English medium school in India. Methods A total of 136 students across 6 classrooms were rando…

RACER: A Non-Commercial Driving Game which Became a Serious Tool in the Research of Driver Fatigue

2008

Precursors of the evoked K-complex in event-related brain potentials in stage 2 sleep.

1997

The aim of the study was to examine precursors of the evoked K-complex as manifested in event-related brain potentials (ERPs) during stage 2 sleep. ERPs to infrequent deviant tones of 1100 and 2000 Hz and immediately preceding frequent standard tones of 1000 Hz were compared between trials containing and trials not containing a K-complex (KC trials, NO KC trials, respectively) to the deviant tones. The N350 wave to the deviant tones was markedly larger during the KC than during the NO KC trials. Also the P210 wave to the 2000 Hz deviant tone showed the same phenomenon. No definite evidence was found for the mismatch negativity-like deflection during the KC trials. ERPs to the standard tones…

Brain-Related Research as a Support Mechanism to Help Learners to Acquire Full Literacy

2023

Possibly some of the most important skills that one can have are those needed to become fully literate. We all wish our children to reach such a goal. Unfortunately, the focus of attention in reading research has been on acquiring readiness to sound out written language, i.e., the basic reading skills. Full literacy is the readiness to learn knowledge by reading. Thus, one has to be able to take two steps to reach full literacy. Indications related to both of these steps can be observe in the brain. This may be easiest when we observe the brain activity of a learner who faces difficulties in taking these steps. In fact, the serious difficulty of taking the first step can be observed soon af…

Precursors and consequences of phonemic length discrimination ability problems in children with reading disabilities and familial risk for dyslexia.

2013

Purpose The authors investigated the importance of phonemic length discrimination ability on reading and spelling skills among children with reading disabilities and familial risk for dyslexia and among children with typical reading skills, as well as the role of prereading skills in reading and spelling development in children with reading disabilities. Method Finnish children with reading disabilities and discrimination problems (RDDP, n = 13), children with reading disabilities and typical discrimination abilities (RDTD, n = 27), and children with typical reading skills (TR, n = 140) were assessed between the ages of 1 and 6.5 years for language, phonological awareness, IQ, verbal memor…

Testing the Effects of GraphoGame Against a Computer-Assisted Math Intervention in Primary School

2022

International audience; Purpose: This study was designed to assess the efficiency of a French version of GraphoGame (GG) against an equally engaging math intervention (Fiete Math, FM) in a large school sample of children from socioeconomically disadvantaged neighborhoods in grade 1 (N = 921). Method: The intervention was implemented in two different cohorts who used GG or FM for about four months four times a week for 30 minutes. Gains in reading and mathematics were assessed before and after intervention. Given the nested nature of the data, results were analyzed using hierarchical linear mixed effect models with intervention and initial pretest level as fixed effects and individuals and c…

A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia.

2007

DYX3, a locus for dyslexia, resides on chromosome 2p11-p15. We have refined its location on 2p12 to a 157 kb region in two rounds of linkage disequilibrium (LD) mapping in a set of Finnish families. The observed association was replicated in an independent set of 251 German families. Two overlapping risk haplotypes spanning 16 kb were identified in both sample sets separately as well as in a joint analysis. In the German sample set, the odds ratio for the most significantly associated haplotype increased with dyslexia severity from 2.2 to 5.2. The risk haplotypes are located in an intergenic region between FLJ13391 and MRPL19/C2ORF3. As no novel genes could be cloned from this region, we hy…

Brain slow waves preceding time-locked visuo-motor performance.

1993

According to previous findings (Konttinen and Lyytinen, 1992), the slow brain negativity preceding the trigger pull in rifle‐shooting tends to be decreased in successful shots among experienced marksmen, whereas no such pattern is found among inexperienced subjects. This effect was interpreted as resulting mainly from optimal arousal. However, another explanation is examined here. The aim of the experiment was to investigate slow electrocortical changes associated with motor regulation and visual aiming related to shooting performance. Four variations on a shooting task were used, in which the visual and motor components were contrasted. Motor activity related to gun stabilization was found…

Parents as Informants of their Child's Vocal and Early Language Development

1996

Continuity in vocalization and language development was examined in the longitudinal study of 94 children. Parents observed their infant's vocal development with the help of a checklist during the first year of life and reported their lexical development by using the MacArthur Communicative Development Inventories (the CDIs) at the ages of 14 and 18 months. The Reynell Developmental Language Scales (the RDLS) were administered to the children in a laboratory setting at 18 months. The vocalization checklist revealed milestones of sound production which parents reported reliably and which were significantly related to the child's later language development. The continuity in vocal and languag…

The Aromatase Gene CYP19A1: Several Genetic and Functional Lines of Evidence Supporting a Role in Reading, Speech and Language

2012

Inspired by the localization, on 15q21.2 of the CYP19A1 gene in the linkage region of speech and language disorders, and a rare translocation in a dyslexic individual that was brought to our attention, we conducted a series of studies on the properties of CYP19A1 as a candidate gene for dyslexia and related conditions. The aromatase enzyme is a member of the cytochrome P450 super family, and it serves several key functions: it catalyzes the conversion of androgens into estrogens; during early mammalian development it controls the differentiation of specific brain areas (e.g. local estrogen synthesis in the hippocampus regulates synaptic plasticity and axonal growth); it is involved in sexua…

Trajectories of reading development: A follow-up from birth to school age of children with and without risk for dyslexia

2006

In order to understand why some children are vulnerable to difficulties in their language development and their acquisition of reading skill, the Jyväskylä Longitudinal Study of Dyslexia followed 200 Finnish children from birth to school age. Half of these children had a family history of reading problems and were considered at risk for dyslexia; the other half were not at risk. A novel analysis, mixture modeling, revealed four subgroups with differential developmental trajectories to early reading. The subgroups who showed either a “dysfluent trajectory” (n = 12; 11 at risk vs. 1 control) or a “declining trajectory” (n = 35; 24 vs. 11) contained more children with familial risk for dyslexi…

In Search of the Core Features of Dyslexia: Observations Concerning Dyslexia in the Highly Orthographically Regular Finnish Language

1995

A goal of many researchers in recent years has been to explore the core feature(s) of dyslexia. Three methods that could be used for this purpose are as follows. One method is to examine and specify in detail the cognitive/reading deficits still present in adulthood and thus to identify deficit(s) instead of a delay. The second method is to use crosslinguistic comparisons (see Jackson, Hu, & Ju, Vol. I, 1994; Assink & Kattenberg, Vol. I, 1994; Wolf, Pfeil, Lotz, & Biddle, Vol. I, 1994). Any real core feature of dyslexia should be present universally independent of the language and language-specific experience among those who have received adequate training in reading. The third method is to…

Brain Slow Potentials Reflecting Successful Shooting Performance

1995

Preparatory brain activity from frontal, centro-lateral, and occipital areas were recorded from top-level rifle shooters during shooting performance. The aim of the study was to examine the relation of brain slow potentials to qualitative (rifle holding) and quantitative (hit) aspects of superior shooting performance. For this purpose, a typology of slow potentials (SPs) was developed. The resulting SP types were used for unraveling the associations between the electrocortical activity and behavioral output. The main finding was that frontal positivity was associated with successful performance, but only if the central-right SP was more negative than the central-left one. This finding was e…

Reading Skills, Acquisition of: Cultural, Environmental, and Developmental Impediments

2015

Reading acquisition is under the influence of the structure and function of the language itself, the individual's capacity to learn and the differential methods of instruction. Alphabetic languages vary from the bidirectionally consistent phoneme–grapheme–phoneme units of Finnish, to English as the most inconsistent for small units, but the latter of which increases in consistency as a function of increasing size of the unit (e.g., rime). Nonalphabetic Chinese places a heavy learning load through its inherently meaning-based logographic structure. Computer-assisted literacy training (e.g., GraphoGame) tailored to language features, teaching practices, and learner specific requirements can p…

Reading development subtypes and their early characteristics.

2007

The present findings are drawn from the Jyväskylä Longitudinal Study of Dyslexia (JLD), in which approximately 100 children with familial risk of dyslexia and 100 control children have been followed from birth. In this paper we report data on the reading development of the JLD children and their classmates, a total of 1,750 children from four measurement points during the first two school years. In the total sample, we examined whether heterogeneous developmental paths can be identified based on profiles of word recognition and reading comprehension. Secondly, we studied what kind of early language and literacy skill profiles and reading experiences characterize the children with differing …

A Bayesian-optimal principle for learner-friendly adaptation in learning games

2010

Abstract Adaptive learning games should provide opportunities for the student to learn as well as motivate playing until goals have been reached. In this paper, we give a mathematically rigorous treatment of the problem in the framework of Bayesian decision theory. To quantify the opportunities for learning, we assume that the learning tasks that yield the most information about the current skills of the student, while being desirable for measurement in their own right, would also be among those that are efficient for learning. Indeed, optimization of the expected information gain appears to naturally avoid tasks that are exceedingly demanding or exceedingly easy as their results are predic…

Very early phonological and language skills: estimating individual risk of reading disability

2007

Background: Analyses from the JyvaskylaLongitudinal Study of Dyslexia project show that the key childhood predictors (phonological awareness, short-term memory, rapid naming, expressive vocabu- lary, pseudoword repetition, and letter naming) of dyslexia differentiate the group with reading disability (n ¼ 46) and the group without reading problems (n ¼ 152) at the end of the 2nd grade. These measures were employed at the ages of 3.5, 4.5 and 5.5 years and information regarding the familial risk of dyslexia was used to find the most sensitive indices of an individual child's risk for reading disabil- ity. Methods: Age-specific and across-age logistic regression models were constructed to pro…

Common variance in amplitude envelope perception tasks and their impact on phoneme duration perception and reading and spelling in Finnish children w…

2009

ABSTRACTOur goal was to investigate auditory and speech perception abilities of children with and without reading disability (RD) and associations between auditory, speech perception, reading, and spelling skills. Participants were 9-year-old, Finnish-speaking children with RD (N = 30) and typically reading children (N = 30). Results showed significant group differences between the groups in phoneme duration discrimination but not in perception of amplitude modulation and rise time. Correlations among rise time discrimination, phoneme duration, and spelling accuracy were found for children with RD. Those children with poor rise time discrimination were also poor in phoneme duration discrimi…

The development of phonological abilities and their relation to reading acquisition: case studies of six Finnish children.

1999

The relation between phonological abilities and reading acquisition and the interindividual variation in the development of different phonological manipulation skills were assessed for six 7-year-old Finnish nonreaders. Intensive time series data were collected by following the children for 13 months. Assessments were conducted every 4 weeks with five phonological manipulation tests. The results indicated gradual progress at the group level. However, analysis of the individual profiles indicated large interindividual variation in the rate of improvement and in the relation between different manipulation skills and reading acquisition.

Event-related potentials in newborns with and without familial risk for dyslexia: principal component analysis reveals differences between the groups

2003

Differences revealed by factor scores extracted by principal component analysis (PCA) from event-related potential (ERP) data of newborns with and without familial risk for dyslexia were examined and compared to results obtained by using original averaged ERPs. ERPs to consonant-vowel syllables (synthetic /ba/, /da/, /ga/; and natural /paa/, /taa/, /kaa/) were recorded from 26 at-risk and 23 control 1-7 day-old infants. The stimuli were presented equiprobably and with interstimulus intervals varying at random from 3,910 to 7,285 ms. Statistically significant between-group differences were found to be relatively similar irrespective of the methods of analysis (original ERPs vs. factor scores…

Developmental pathways of children with and without familial risk for dyslexia during the first years of life.

2002

Comparisons of the developmental pathways of the first 5 years of life for children with (N = 107) and without (N = 93) familial risk for dyslexia observed in the Jyvaskyla Longitudinal study of Dyslexia are reviewed. The earliest differences between groups were found at the ages of a few days and at 6 months in brain event-related potential responses to speech sounds and in head-turn responses (at 6 months), conditioned to reflect categorical perception of speech stimuli. The development of vocalization and motor behavior, based on parental report of the time of reaching significant milestones, or the growth of vocabulary (using the MacArthur Communicative Development Inventories) failed t…

Does mismatch negativity show differences in reading-disabled children compared to normal children and children with attention deficit?

2007

An auditory event-related potential (ERP) component called mismatch negativity (MMN) was examined in three groups of children (n = 63) aged 8-14 years. A control group comprised healthy children in second or sixth grade of comprehensive school (n = 21). The two clinical groups included children with reading disability (RD) (n = 21) and children with attention deficit (AD) (n = 21). MMN was elicited in a passive oddball paradigm by duration changes in a continuous sound, consisting of two alternating (600 and 800 Hz) 100 msec tones. The deviant tones were either 30 or 50 msec in duration. Both deviants elicited a clear MMN in all groups. Statistical analyses showed no systematic difference i…

Orthographic depth and its impact on universal predictors of reading: a cross-language investigation

2010

Alphabetic orthographies differ in the transparency of their letter-sound mappings, with English orthography being less transparent than other alphabetic scripts. The outlier status of English has led scientists to question the generality of findings based on English-language studies. We investigated the role of phonological awareness, memory, vocabulary, rapid naming, and nonverbal intelligence in reading performance across five languages lying at differing positions along a transparency continuum (Finnish, Hungarian, Dutch, Portuguese, and French). Results from a sample of 1,265 children in Grade 2 showed that phonological awareness was the main factor associated with reading performance…

Early development of children at familial risk for Dyslexia—follow-up from birth to school age

2004

We review the main findings of the Jyväskylä Longitudinal study of Dyslexia (JLD) which follows the development of children at familial risk for dyslexia (N = 107) and their controls (N = 93). We will illustrate the development of these two groups of children at ages from birth to school entry in the skill domains that have been connected to reading and reading disability in the prior literature. At school entry, the highest score on the decoding task among the poorer half (median) of the at risk children--i.e. of those presumably being most likely genetically affected--is 1 SD below the mean of the control group. Thus, the familial risk for dyslexia shows expected consequences. Among the e…

Mismatch negativity — Factors affecting its variation

1991

A mobile game as a support tool for children with severe difficulties in reading and spelling

2020

We used a randomized controlled trial to investigate if a mobile game, GraphoLearn (GL), could effectively support the learning of first graders (N = 70), who have severe difficulties in reading and spelling. We studied the effects of two versions of the game: GL Reading, which focused on training letter-sound correspondence and word reading; and GL Spelling, which included additional training in phonological skills and spelling. During the spring of first grade, the children trained with tablet computers which they could carry with them during the six-week intervention. The average exposure time to training was 5 hr 44 min. The results revealed no differences in the development of reading …

PSYCHOPHYSIOLOGICAL AROUSAL RELATED TO TYPE-A COMPONENTS IN ADOLESCENT BOYS

1995

The association between psychophysiological responses (heart rate, skin conductance and blood volume) and Type A behavior was studied in adolescent boys (n = 48) in computer-controlled experiments. Although psychophysiological arousal was related to the type of stress-evoking element, task-specificity did not result in significant psychophysiological differences between Type As and Nontype As. The indication is that physiological arousal may be a constitutional characteristic of Type A behavior. The multidimensionality of type A behavior must be considered in any investigation examining the psychophysiological Type A-Nontype A differences. Different Type A dimensions, together with previous…

Auditory event-related potentials (ERP) reflect temporal changes in speech stimuli

1997

We studied the brain's reactions to deviations in the duration of a stop consonant using event-related potentials in an oddball paradigm. A naturally produced nonsense word was used as a frequent standard stimulus which differed from two infrequently presented deviant stimuli only by the duration of the silence period inside the stop, making the consonant sound longer. Evoked responses to the deviant stimuli showed sharply rising negativity after the unexpected prolongation of the silence and a later negativity, the duration of which was related to the timing of the beginning of the second part of the deviant sound. This later negativity is, at least partly, elicited by a mismatch process t…

Cortical responses of infants with and without a genetic risk for dyslexia

1999

We studied auditory event-related potentials (ERP) in newborns and 6-month-old infants, about half of whom had a familial risk for dyslexia. Syllables varying in vowel duration were presented in an oddball paradigm, in which ERPs to deviating stimuli are assumed to reflect automatic change detection in the brain. The ERPs of newborns had slow positive deflections typical of their age, but significant stimulus and group effects were found only by the age of 6 months. In both groups, the responses to the deviant /ka/ were more positive than those to the standard /kaa/ stimuli, contrary to the findings of adult ERPs to duration changes. The results also suggested differences in brain activatio…

Spoken-Word Segmentation and Dyslexia

2002

We used magnetoencephalography to elucidate the cortical activation associated with the segmentation of spoken words in nonreading-impaired and dyslexic adults. The subjects listened to binaurally presented sentences where the sentence-ending words were either semantically appropriate or inappropriate to the preceding sentence context. Half of the inappropriate final words shared two or three initial phonemes with the highly expected semantically appropriate words. Two temporally and functionally distinct response patterns were detected in the superior temporal lobe. The first response peaked at approximately 100 msec in the supratemporal plane and showed no sensitivity to the semantic appr…

Computer game as a tool for training the identification of phonemic length.

2013

Computer-assisted training of Finnish phonemic length was conducted with 7-year-old Russian-speaking second-language learners of Finnish. Phonemic length plays a different role in these two languages. The training included game activities with two- and three-syllable word and pseudo-word minimal pairs with prototypical vowel durations. The lowest accuracy scores were recorded for two-syllable words. Accuracy scores were higher for the minimal pairs with larger rather than smaller differences in duration. Accuracy scores were lower for long duration than for short duration. The ability to identify quantity degree was generalized to stimuli used in the identification test in two of the childr…

Developmental Underpinnings of the Association of Attention Deficit Hyperactivity Disorder and Its Subtypes to Neuropsychological and Academic Weakne…

2005

Caron and Rutter (1) and Pennington (2) recently published excellent conceptual and methodological reviews and analyses of comorbidity in child psychopathology, and a special issue of Developmental Neuropsychology (3) reviewed attention deficit hyperactivity disorder (ADHD)-learning disabilities (LD) comorbidity in particular. None of these reviews, however, focused on the association of dimensions of ADHD and cognitive development, which are included in this chapter. Moreover, relatively little empirical data exist from early development. It is very likely that language-related impairments and extreme temperament traits contribute to the emergence of developmental problems and/or the accum…

Genome-wide association analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people

2021

AbstractThe use of spoken and written language is a capacity that is unique to humans. Individual differences in reading- and language-related skills are influenced by genetic variation, with twin-based heritability estimates of 30-80%, depending on the trait. The relevant genetic architecture is complex, heterogeneous, and multifactorial, and yet to be investigated with well-powered studies. Here, we present a multicohort genome-wide association study (GWAS) of five traits assessed individually using psychometric measures: word reading, nonword reading, spelling, phoneme awareness, and nonword repetition, with total sample sizes ranging from 13,633 to 33,959 participants aged 5-26 years (1…

Late-Emerging and Resolving Dyslexia

2015

This study focuses on the stability of dyslexia status from Grade 2 to Grade 8 in four groups: (a) no dyslexia in either grade (no-dyslexia, n = 127); (b) no dyslexia in Grade 2 but dyslexia in Grade 8 (late-emerging, n = 18); (c) dyslexia in Grade 2 but not in Grade 8 (resolving, n = 15); and (d) dyslexia in both grades (persistent-dyslexia, n = 22). We examined group differences from age 3.5 to age 14 in (a) reading, vocabulary, phonology, letter knowledge, rapid naming, IQ, verbal memory; (b) familial and environmental risk and supportive factors; and (c) parental skills in reading, phonology, rapid naming, verbal memory, and vocabulary. Our findings showed group differences both in read…

Developmental links of very early phonological and language skills to second grade reading outcomes: strong to accuracy but only minor to fluency.

2008

The authors examined second grade reading accuracy and fluency and their associations via letter knowledge to phonological and language predictors assessed at 3.5, 4.5, and 5.5 years in children in the Jyväskylä Longitudinal Study of Dyslexia. Structural equation modeling showed that a developmentally highly stable factor (early phonological and language processing [EPLP]) behind key dyslexia predictors (i.e., phonological awareness, short-term memory, rapid naming, vocabulary, and pseudoword repetition) could already be identified at 3.5 years. EPLP was significantly associated with reading and spelling accuracy and by age with letter knowledge. However, EPLP had only a minor link with re…

Developmental Dyslexia in Finnish

2019

Infant brain responses associated with reading-related skills before school and at school age

2011

Summary Introduction In Jyvaskyla Longitudinal Study of Dyslexia, we have investigated neurocognitive processes related to phonology and other risk factors of later reading problems. Here we review studies in which we have investigated whether dyslexic children with familial risk background would show atypical auditory/speech processing at birth, at six months and later before school and at school age as measured by brain event-related potentials (ERPs), and how infant ERPs are related to later pre-reading cognitive skills and literacy outcome. Patients and methods One half of the children came from families with at least one dyslexic parent (the at-risk group), while the other half belonge…

Drawback of ICA Procedure on EEG: Polarity Indeterminacy at Local Optimization

2008

Independent component analysis (ICA) has been extensively applied to reject artifacts in electroencephalography (EEG) signal processing. The first step is to extract the independent component activations from the electrode records, and then project the desired components back to the electrodes. After the composition of the projected component is analyzed in details under ICA procedure, this study shows that since ICA may extract some source components at the local optimization in high-dimensional EEG signal space, the artificial polarity indeterminacy may happen on the projected component at some electrodes. By numerical simulations, this issue also exhibits that this polarity ambiguity occ…

Processing of auditory stimuli during tonic and phasic periods of REM sleep as revealed by event-related brain potentials

1996

The brain has been reported to be more preoccupied with dreams during phasic than during tonic REM sleep. Whether these periods also differ in terms of the processing of external stimuli was examined. Event-related brain potentials (ERPs) to a frequent standard tone of 1000 Hz (P = 97%) and infrequent deviant tones of 1100 and 2000 Hz (P = 1.5% for each) were recorded (n = 13) during wakefulness and nocturnal sleep. An ERP wave (called REM-P3) resembling a waking P3 wave was larger for the 2000 Hz deviant during tonic than during phasic REM sleep. Also the P210 wave was larger during tonic than during phasic REM sleep. A reliable mismatch negativity component appeared only in wakefulness. I…

Auditory Event-Related Potentials in the Study of Developmental Language-Related Disorders

1997

This article reviews recent auditory event-related potential (ERP) studies of developmental language disorder (DLD) and dyslexia/reading disorder (RD). The possibility of using ERPs in searching for precursors of these disorders in the early development of infants at risk is also discussed. Differences in exogenous/sensory ERPs at the latency range of P1 and N1-P2 components have been reported between groups with DLD and RD and control groups. Latency differences between the groups may be related to a common timing deficit suggested by some researchers to be one of the possible underlying factors both in DLD and dyslexia. N1 amplitude group differences may be partly related to arousal/atten…

Assessing Reading Skills with a Computer-aided Set of Tests Based on the Dual-route Theory of Reading

1993

Long-Term Intervention Effects of Spelling Development for Children With Compromised Preliteracy Skills

2013

The aim of this longitudinal study was to build a model of the predictive values (poor phonological awareness, low letter knowledge, and slow naming speed) of spelling in 3 contrasting reading groups: a regular and a computer-assisted remedial intervention and mainstream instruction. The participants were 7-year-old Finnish school beginners (N = 166). The interventions took place in 4 weekly sessions of 45 min each over a period of 28 weeks in groups of 5 during Grade 1. We compared postintervention spelling development across the groups. The children who received systematic phonics-based training via the computer-assisted intervention reached the postinstruction level of the mainstream gro…

Rapid serial naming: relations between different stimuli and neuropsychological factors.

2004

We report two studies on rapid serial naming (RSN). Study 1 addressed the relations among RSN tasks comprising different stimuli. Separate components for RSN of alphanumeric and non-alphanumeric stimuli, as well as for tasks in which the stimuli alternated between categories were identified. In Study 2, phonological skills, processing speed, motor dexterity, and verbal fluency were found to explain RSN performance. The studies indicate: (1) that RSN tasks vary in their properties according to the stimuli used and according to the way the tasks are arranged, and (2) that RSN tasks are multi-componented.

Co-occurrence of developmental delays in a screening study of 4-year-old Finnish children

2004

The aim of this population study was to examine the severity and prevalence of co-occurring developmental delays in 4-year-old children, the rate of overlapping problems, and sex differences. A sample of 434 children (196 males, 238 females; mean age 4 years 3 months, SD 1 month) were administered the 'Lene' test: a comprehensive neurodevelopmental screening test. Results suggest that co-occurrence of attention-behavioural, motor-perceptual, and language delays occurring in school-aged children could already be detected at the age of 4 years. Isolated delays were usually mild, but co-occurring difficulties were mostly moderate or severe. Overlap between developmental delays depended on the …

An offline/real-time artifact rejection strategy to improve the classification of multi-channel evoked potentials

2008

The primary goal of this paper is to improve the classification of multi-channel evoked potentials (EPs) by introducing a temporal domain artifact detection strategy and using this strategy to (a) evaluate how the performance of classifiers is affected by artifacts and (b) show how the performance can be improved by detecting and rejecting artifacts in offline and real-time classification experiments. Using a pattern recognition approach, an artifact is defined in this study as any signal that may lead to inaccurate classifier parameter estimation and inaccurate testing. The temporal domain artifact detection tests include: a within-channel standard deviation (STD) test that can detect sign…

Newborn event-related potentials predict poorer pre-reading skills in children at risk for dyslexia.

2009

Earlier results from the Jyväskylä Longitudinal Study of Dyslexia showed that newborn event-related potentials (ERPs) of children with and without familial risk for dyslexia were associated with receptive language and verbal memory skills between 2.5 and 5 years of age. We further examined whether these ERPs (responses to synthetic consonant-vowel syllables /ba/, /da/, /ga/; presented equiprobably with 3,910—7,285 ms interstimulus intervals) predict later pre-reading skills measured before the onset of school (6.5 years of age). In line with our earlier results, the at-risk children ( N = 11) with atypical speech processing in the right hemisphere (a slower shift in polarity from positivit…

Comorbidity and developmental neurocognitive disorders

1995

Language Development and Symbolic Play in Children With and Without Familial Risk for Dyslexia

2001

The purposes of this study were to investigate (a) whether children in families with a positive history of dyslexia were more likely to show delays in language development than children without family risk and (b) whether a delayed onset of expressive language (late talking) predicted later language development. We analyzed the language development of 200 children longitudinally at 14, 24, 30, and 42 months and assessed their symbolic play at 14 months. Half of the children ( N =106) were from families with a history of dyslexia (the Dyslexia Risk [DR] group), and other children served as age-matched controls. Parental reports and structured tests were used to assess children’s receptive a…

Maternal history of reading difficulty is associated with reduced language-related gray matter in beginning readers.

2012

Family history and poor preliteracy skills (referred to here as familial and behavioral risk, respectively) are critical predictors of developmental dyslexia. This study systematically investigated the independent contribution of familial and behavioral risks on brain structures, which had not been explored in past studies. We also examined the differential effects of maternal versus paternal history on brain morphometry, and familial risk dimensionally versus categorically, which were also novel aspects of the study. We assessed 51 children (5 to 6 years of age) with varying degrees of familial and behavioral risks for developmental dyslexia and examined associations with brain morphometry…

Cry characteristics of 172 healthy 1-to 7-day-old infants.

2002

A total of 1,836 cry signals from 172 healthy babies, 1–7 days old, were analysed with sound spectrography. The mean values for the 8–15 cries from each infant were calculated and used for the statistical analyses. The mean duration of the cry signals was 1.4 ± 0.6 s. The mean fundamental frequency was 496 ± 95 cps (Hz). Fifty percent of the mean fundamental frequencies in the 8–15 cries analysed from each baby varied between 450 and 520 Hz. Of the children, 93% had cries with a mean fundamental frequency below 600 Hz. The mean value of the highest point of the fundamental frequency was 583 ± 151 Hz and of the lowest point 398 ± 75 Hz. The melody type had mainly a rising-falling contour, th…

Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort

2013

The work conducted at the WTCHG was supported by Wellcome Trust grants [076566/Z/05/Z] and [075491/Z/04]; the work in Zurich partly by an SNSF grant [32-108130]. We also thank MAF (Mutation Analysis core Facility) at the Karolinska Institute, Novum, Huddinge. The French part of the project was funded by Agence Nationale de la Recherche (ANR-06-NEURO-019-01 GENEDYS) and Ville de Paris. S Paracchini is a Royal Society University Research Fellow. D Czamara was supported by the Deutsche Forschungsgemeinschaft (German Research Foundation) within the framework of the Munich Cluster for Systems Neurology (EXC 1010 SyNergy). Dyslexia is one of the most common childhood disorders with a prevalence o…

Supporting Acquisition of Spelling Skills in Different Orthographies Using an Empirically Validated Digital Learning Environment

2021

This paper discusses how the association learning principle works for supporting acquisition of basic spelling and reading skills using digital game-based learning environment with the Finland-based GraphoLearn (GL) technology. This program has been designed and validated to work with early readers of different alphabetic writing systems using repetition and reinforcing connections between spoken and written units. Initially GL was developed and found effective in training children at risk of reading disorders in Finland. Today GL training has been shown to support learning decoding skills among children independent of whether they face difficulties resulting from educational, social, or bi…

Training Reading Skills in Finnish: From Reading Acquisition to Fluency and Comprehension

2016

This chapter outlines the approaches for supporting reading development in Finnish that have been developed on the basis of current knowledge on reading development and reading disabilities in Finnish. We discuss also the challenges that the features of Finnish language and orthography pose for the reader at various points of development. We also describe the means for supporting the acquisition of the earliest milestones in reading development, that are being used widely within the Finnish elementary schools, and that have been based on findings of a large longitudinal research project (Jyvaskyla Longitudinal Study of Dyslexia, JLD). Although the knowledge on the development of reading flu…

Independent component analysis on the mismatch negativity in an uninterrupted sound paradigm.

2008

We compared the efficiency of the independent component analysis (ICA) decomposition procedure against the difference wave (DW) and optimal digital filtering (ODF) procedures in the analysis of the mismatch negativity (MMN). The comparison was made in a group of 54 children aged 8-16 years. The MMN was elicited in a passive oddball protocol presenting uninterrupted auditory stimulation consisting of two frequent alternating tones (600 and 800 Hz) of 100 ms duration each. Infrequently, one of the 600 Hz tones was shortened to 50 or 30 ms. The event related potentials (ERPs) were decomposed into the MMN-like and non-MMN-like independent components (ICs) through the FastICA algorithm. The ICA …

Insulin resistance syndrome and autonomically mediated physiological responses to experimentally induced mental stress in adolescent boys

1996

We investigated the relationship between hemodynamic and other autonomically mediated responses to experimentally induced mental stress and the parameters of the insulin resistance syndrome (IRS) in 48 healthy adolescent boys. Mental stress was induced with mental arithmetic and the Stroop Color-Word Test. Heart rate (HR), finger blood volume (FBV), and skin conductance level (SCL) were recorded continuously during task performance. IRS parameters measured were serum insulin, high-density lipoprotein (HDL) cholesterol, serum triglyceride (TG), systolic blood pressure (SBP), subscapular skinfold (SSF), and subscapular to triceps skinfold ratio (STR). The results indicated that a high level a…

Neurocognitive Developmental Disorders: A Real Challenge for Developmental Neuropsychology

2002

Early identification of dyslexia and the use of computer game-based practice to support reading acquisition

2007

The validity of early predictive measures of delayed reading acquisition is summarized on the basis of the Jyvaskyla Longitudinal study of Dyslexia (JLD). These results show that children in need of support can be identified years before school age. After a brief review of the literature on computer-based interventions, pilot data is reported on the effects of our computer game ‘Literate’ that has been specially developed for preventive training with children who are at risk of failing to acquire reading skill at a normal rate.

Psychophysiology of developmental dyslexia: a review of findings including studies of children at risk for dyslexia

2005

Abstract Brain imaging results illustrative of the search for neuronal markers of dyslexia are reviewed. Event-related potentials (ERPs) are shown to be effective indices of auditory processes involved in speech perception and thus, apparently also helpful in uncovering the neuronal basis of language problems associated with difficulties in reading. Results from the authors' laboratory show that, even at a very early age, brain responses (ERPs) to speech sounds can differentiate children with and without risk for dyslexia and also show reliable predictive correlations to later language development and reading acquisition. The review also covers dyslexia research in which other brain imaging…

BENEFITS OF MULTI-DOMAIN FEATURE OF MISMATCH NEGATIVITY EXTRACTED BY NON-NEGATIVE TENSOR FACTORIZATION FROM EEG COLLECTED BY LOW-DENSITY ARRAY

2012

Through exploiting temporal, spectral, time-frequency representations, and spatial properties of mismatch negativity (MMN) simultaneously, this study extracts a multi-domain feature of MMN mainly using non-negative tensor factorization. In our experiment, the peak amplitude of MMN between children with reading disability and children with attention deficit was not significantly different, whereas the new feature of MMN significantly discriminated the two groups of children. This is because the feature was derived from multi-domain information with significant reduction of the heterogeneous effect of datasets.

ERP denoising in multichannel EEG data using contrasts between signal and noise subspaces

2009

Abstract In this paper, a new method intended for ERP denoising in multichannel EEG data is discussed. The denoising is done by separating ERP/noise subspaces in multidimensional EEG data by a linear transformation and the following dimension reduction by ignoring noise components during inverse transformation. The separation matrix is found based on the assumption that ERP sources are deterministic for all repetitions of the same type of stimulus within the experiment, while the other noise sources do not obey the determinancy property. A detailed derivation of the technique is given together with the analysis of the results of its application to a real high-density EEG data set. The inter…

Corpus Callosum Morphology in Attention Deficit-Hyperactivity Disorder: Morphometric Analysis of MRI

1991

Although behavioral evidence provides support for the notion that attention deficit-hyperactivity disorder (ADHD) is related to central nervous system dysfunction, there is little direct evidence to reveal which neurometabolic systems or brain structures are involved. Recent magnetic resonance imaging (MRI) studies suggest that, compared to nondisabled controls, ADHD children may have a smaller right frontal region. Morphometric analysis of MRI scans was used in this exploratory study to determine whether correlated regional variation might exist in the corpus callosum of children with ADHD. While all MRI scans were judged to be clinically normal, morphometric analysis revealed that, compa…

Ensuring Sufficient Literacy Practice with Tablet Technology in Zambian Schools

2015

Tablets are a promising mobile device for disseminating e-Learning materials at schools in Africa. E-learning materials can be especially useful for the practice of early literacy skills. Introducing mobile devices to schools can be challenging as teachers are required to make changes to their daily routines and the use of technology can be problematic in overcrowded classrooms. This study aimed to find out the most optimal way of providing GraphoGame literacy intervention via tablets for grade one learners in an urban school environment. The study tested whether GraphoGame mounted on tablets increases initial literacy skills among grade one learners. Three different conditions for providin…

ERP qualification exploiting waveform, spectral and time-frequency infomax

2008

The present contribution briefly introduces an event related potential (ERP) detector. The specified detector includes three kinds of features of ERP. They are the ERP waveform feature, ERP spectral feature and ERP time-frequency feature respectively. According to these characteristics, two parameters are defined to reflect the timing feature of ERP. The mismatch negativity (MMN) is taken as the example to design an exact qualification detector. The experiment validates that the computer can automatically detect the raw trace to reflect the quality of the dataset, qualify the filtered trace to test whether the artifacts have been filtered out, and select the ERP-like component to reject art…

Genome Wide Association Scan identifies new variants associated with a cognitive predictor of dyslexia

2018

AbstractDevelopmental dyslexia (DD) is one of the most prevalent learning disorders among children and is characterized by deficits in different cognitive skills, including reading, spelling, short term memory and others. To help unravel the genetic basis of these skills, we conducted a Genome Wide Association Study (GWAS), including nine cohorts of reading-impaired and typically developing children of European ancestry, recruited across different countries (N=2,562-3,468).We observed a genome-wide significant effect (p&lt;1×10−8) on rapid automatized naming of letters (RANlet) for variants on 18q12.2 withinMIR924HG (micro-RNA 924 host gene;p= 4.73×10−9), and a suggestive association on 8q1…

Sublexical effects on eye movements during repeated reading of words and pseudowords in Finnish

2011

The role of different orthographic units (letters, syllables, words) in reading of orthographically transparent Finnish language was studied by independently manipulating the number of letters (NoL) and syllables (NoS) in words and pseudowords and by recording eye movements during repeated reading aloud of these items. Fluent adult readers showed evidence for using larger orthographic units in (pseudo)word recoding, whereas dysfluent children seem to be stuck in a letter-based decoding strategy, as lexicality and item repetition decreased the NoL effect only among adult readers. The NoS manipulation produced weak repetition effects in both groups. However, dysfluent children showed evidence…

Timing of Triggering in Relation to the Cardiac Cycle in Nonelite Rifle Shooters

2003

This study investigated the timing of the trigger pull in relation to the cardiac cycle during air rifle shooting. Electrocardiogram) was recorded from 20 male nonelite rifle shooters in two separate testing sessions. The testing was conducted at an indoor shooting range using an optoelectronic shooting system. Each participant fired a shot in the standing position at a distance of 10 m from the target. The results showed that compared to random triggering, the shooters fired more often during the phase of 10-50% of the R wave-to-R wave (R-R) interval and less often during the phase of 50-90%. With regard to performance accuracy, the participants exhibited average or above average performan…

Assessing the Effectiveness of Two Theoretically Motivated Computer-Assisted Reading Interventions in the United Kingdom: GG Rime and GG Phoneme

2013

We report an empirical comparison of the effectiveness of two theoretically motivated computer-assisted reading interventions (CARI) based on the Finnish GraphoGame CARI: English GraphoGame Rime (GG Rime) and English GraphoGame Phoneme (GG Phoneme). Participants were 6–7-year-old students who had been identified by their teachers as being relatively poor at reading. The students were divided into three groups. Two of the groups played one of the games as a supplement to normal classroom literacy instruction for five sessions per week for a period of 12 weeks. The third group formed an untreated control. Both games led to gains in reading, spelling, and phonological skills in comparison with…

A Culturally Sensitive Approach to Promoting Initial Literacy Development in Africa : Ongoing and Planned Research and Development at the University …

2017

A four-year research and development program at CAPOLSA (the Centre for the Promotion of Literacy in Sub-Saharan Africa) was inspired by widespread dissatisfaction with poor literacy outcomes of mass basic schooling in Zambia and sought to test the generalizability of a scientifically grounded, computer-mediated instructional resource developed in Finland, for effective intervention in an African society where different linguistic and educational conditions obtain. Specific challenges and opportunities posed by the local sociocultural context included the prevalence of multilingualism, the relatively transparent orthographies of local languages, and poor infrastructure of the public school …

Speech- and sound-segmentation in dyslexia: evidence for a multiple-level cortical impairment

2006

Developmental dyslexia involves deficits in the visual and auditory domains, but is primarily characterized by an inability to translate the written linguistic code to the sound structure. Recent research has shown that auditory dysfunctions in dyslexia might originate from impairments in early pre-attentive processes, which affect behavioral discrimination. Previous studies have shown that whereas dyslexic individuals are deficient in discriminating sound distinctions involving consonants or simple pitch changes, discrimination of other sound aspects, such as tone duration, is intact. We hypothesized that such contrasts that can be discriminated by dyslexic individuals when heard in isolat…

Abnormal Auditory Cortical Activation in Dyslexia 100 msec after Speech Onset

2002

Abstract Reading difficulties are associated with problems in processing and manipulating speech sounds. Dyslexic individuals seem to have, for instance, difficulties in perceiving the length and identity of consonants. Using magnetoencephalography (MEG), we characterized the spatio-temporal pattern of auditory cortical activation in dyslexia evoked by three types of natural bisyllabic pseudowords (/ata/, /atta/, and /a a/), complex nonspeech sound pairs (corresponding to /atta/ and /a a/) and simple 1-kHz tones. The most robust difference between dyslexic and non-reading-impaired adults was seen in the left supratemporal auditory cortex 100 msec after the onset of the vowel /a/. This N100m…

The play and language behavior of mothers with and without dyslexia and its association to their toddlers' language development.

2004

The play and language behavior of mothers with ( n = 49) and without ( n = 49) specific reading disabilities (RD) was investigated during play with their 14-month-old children. The contribution of maternal behavior to the language development of their children was examined. The children's receptive and expressive language skills were assessed longitudinally at 14, 18, and 30 months, using the MacArthur Communicative Development Inventories and the Reynell Developmental Language Scales. Children with and without familial risk for RD did not differ from each other in any play or language measures at these ages. No group differences were found for mothers' manifestations of nonsymbolic play a…

Development of early motor skills and language in children at risk for familial dyslexia

2007

Differences in motor development and the relationship between motor and language development were studied in 88 children with familial risk for dyslexia (43 females, 45 males; at-risk group) and 88 children without familial risk for dyslexia (35 females, 53 females; control group; n=176) during the first two years of life. A structured parental questionnaire was used to assess motor development. Expressive language skills were assessed at the age of 18 months with the Reynell Developmental Language Scales and at 18 and 24 months with the MacArthur Communicative Development Inventories. At group level, the motor development of children in both the at-risk and control groups was similar. Howe…

Concatenated trial based Hilbert-Huang transformation on event-related potentials

2010

Time-frequency analysis is critical to study event-related potentials (ERPs) now. ERPs are usually generated through averaging over a number of trials, and such averaging limits the application of a nonlinear time-frequency analysis method—Hilbert-Huang transformation (HHT). This is because HHT usually requires very long recordings to sufficiently decompose the complicated signal into oscillations and the averaged ERP trace tends to possess only hundreds of samples. Thus, this study designs the concatenated trial based HHT to release the limitation on the decomposition. Such a paradigm may reveal better temporal and spectral properties of an ERP than the conventional wavelet transformation …

A robust approach to ERP denoising

2010

The purpose of presented study is to explore possibilities to increase the robustness and improve the performance of the spatial ERP denoising methods proposed in earlier research. The quality of the subspace separation solution may easily be degraded essentially, if the underlying assumptions become noticeably violated, which is a normal situation in practice. The distortions to the results of a separation are caused by non-zero sample signal-noise and noise-noise correlations, which are indistinguishable from the variances of the signal and noise in the framework of the second-order statistical information exploited by the discussed methods. Therefore, in the research reported in this art…

Development of auditory processing ability in children with dyslexia

2012

Comparing Efficacies of Neurocognitive Treatment and Homework Assistance Programs for Children with Learning Difficulties

1997

The purpose of the study was to analyze the relative efficacies of two treatments for children with learning difficulties. The first treatment consisted of multiple training components targeting specific cognitive and behavioral factors; the second treatment provided emotional support and supervision of school tasks. The participants were 94 Chilean schoolchildren (6 to 11 years of age). The efficacies were compared on (a) neurocognitive tests, (b) school achievement tests, and (c) behavior in school and at home. The results indicated that both groups improved on most of the outcome measures. The first group showed best results in parents' rating of home behavior, and the second group in r…

The early motor milestones in infancy and later motor skills in toddlers: a structural equation model of motor development.

2006

The relationship between the achievement of early motor milestones in infancy and later motor development was studied in 130 children with (N = 66, 35 male/31 female) and without (N = 64, 31 male/35 female) familial risk for dyslexia. A structured parental questionnaire was used to assess motor development in infancy, and the Movement Assessment Battery for Children was used to assess motor skills at age 3.5 years. No differences were found at the group level and therefore the structural equation model was constructed by entering both groups simultaneously. An Early Body Control factor, computed from the infant data, explained 38% of the variance of the Gross Motor Skills factor at the age …

A potential real-time procedure to evaluate correlation of recordings among single trials (CoRaST) for mismatch negativity (MMN) with Fourier transfo…

2011

Abstract Objective To design a fast algorithm that evaluates the degree of correlation of recordings among single trials (CoRaST) for mismatch negativity (MMN) activity. Methods The participants were 114 children, aged 8–16 years. MMNs were elicited by two deviants in duration that occurred in an uninterrupted sound within a passive oddball paradigm, and each trial lasted 650 ms with 130 samples. CoRaST was derived from the frequency-domain MMN model through Fourier transformation. To validate the effectiveness of the proposed method, the wavelet transformation-based inter-trial coherence (ITC) was taken as a reference. Results Performances of the proposed CoRaST and ITC were similar in eva…

Assessment of Three-and-a-Half-Year-Old Children's Emerging Phonological Awareness in a Computer Animation Context

2003

Four computer-animated tasks were created to analyze the underlying structure of emerging phonological awareness at 3.5 years of age and to explore the factors that influence children's ( N = 91) performance on the tasks. Our findings indicated that already at this young age, children are able to master tasks demanding identification, blending, and continuation of phonological units when the tasks are presented in a motivating assessment context. In line with earlier research, children showed higher mastery in dealing with words and syllables than in dealing with phonemes. Targets in the initial position of a word were easier for children to identify than those in the final position. Our an…

A computer-based Pinyin intervention for disadvantaged children in China: Effects on Pinyin skills, phonological awareness, and character reading.

2019

Pinyin is an alphabetic script that denotes pronunciations of Chinese characters. Studies have shown that Pinyin instruction enhances both phonological awareness (e.g., Shu et al., Developmental Science, 2008, 11, 171-181) and character reading (e.g., Lin et al., Psychological Science, 2010, 21, 1117-1122) in Chinese children. In the present study, we provided a 3-week Pinyin intervention with a computer-based Pinyin GraphoGame to disadvantaged migrant children with poor Pinyin skills. A total of 252 first graders who were children of migrant workers in a large Chinese city were assessed to identify poor Pinyin readers. Fifty-six 7-year-old children with poor Pinyin skills were selected and…

Brain ERPs to changes of speech segment durations in six-month-olds

1997

The role of achievement beliefs and behaviours in spontaneous reading acquisition

2006

Abstract This study examined the role of motivational or attitudinal factors, such as achievement beliefs and behaviours, in learning to read before receiving formal instruction. A total of 200 Finnish children were examined at ages 5 and 6½. Half of them ( n  = 107) had a familial risk for dyslexia. The results showed that those children who were verbally skilful at age 5 showed a higher level of task-focused behaviour at age 6½. This task-focused behaviour then contributed to spontaneous reading acquisition. The impact of previous verbal skills on spontaneous reading acquisition was mediated in part by achievement behaviour.

Miten tunnistat lapsen joka tarvitsee apua saavuttaakseen peruslukutaidon ja miten tuen häntä?

2015

Modeling the early paths of phonological awareness and factors suopporting its development in children with and without familiar risk of dyslexia

2007

The development of phonological awareness (PA) before school age was modeled in association with the development of vocabulary and letter knowledge, home literacy environment (HLE), children's reading interest, and beginning reading skill in children with and without familial risk of dyslexia. A total of 186 children were followed from birth to the age of 6.5 years. Of these children, about half had a familial background of reading difficulties (the at-risk group), and the other half came from families without such background (the control group). The data from several measures and assessment time points were analyzed within an SEM framework, and a latent analysis of growth curves was employ…

Game learning analytics for understanding reading skills in transparent writing system

2020

Serious games are designed to improve learning instead of providing only entertainment. Serious games analytics can be used for understanding and enhancing the quality of learning with serious games. One challenge in developing computerized support for learning is that learning of skills varies between players. Appropriate algorithms are needed for analyzing the performance of individual players. This paper presents a novel clustering-based profiling method for analyzing serious games learners. GraphoLearn, a game for training connections between speech sounds and letters, serves as the game-based learning environment. The proposed clustering method was designed to group the learners into p…

Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia

2021

Developmental dyslexia (DD) is a learning disorder affecting the ability to read, with a heritability of 40–60%. A notable part of this heritability remains unexplained, and large genetic studies are warranted to identify new susceptibility genes and clarify the genetic bases of dyslexia. We carried out a genome-wide association study (GWAS) on 2274 dyslexia cases and 6272 controls, testing associations at the single variant, gene, and pathway level, and estimating heritability using single-nucleotide polymorphism (SNP) data. We also calculated polygenic scores (PGSs) based on large-scale GWAS data for different neuropsychiatric disorders and cortical brain measures, educational attainment,…

Lukivaikeuksien ennalta tunnistuksen ja ehkäisyn keinot - ja niiden perustelut

2016

Kielikukossa 4/2015 kävimme läpi lukivaikeuksia koskevaa tietämystä tuen tarpeessa olevan lapsen tunnistamisesta ja vaikeuksien ennaltaehkäisystä. Tässä artikkelissa esittelemme näiden taustalla olevaa tieteellistä näyttöä. Samalla ohjeistamme lukutaitoa opettaville, miten vaikeuksien seurauksia on mahdollista minimoida. nonPeerReviewed

Suomen Akatemian huippuyksikköpolitiikasta lähtölaukaus maailman parantamiseen

2020

Tietokoneavusteinen suomen kielen kvantiteetin harjoittelu: venäjänkielisen suomea opettelevan lapsen ja suomenkielisen luku- ja kirjoitushäiriöisen …

2013

Kaksi ensiluokkalaista lasta, oppimispulmaton venäjänkielinen suomenoppija ja suomenkielinen luku- ja kirjoitushäiriöinen lapsi, joilla kummallakin oli ongelmia vokaalikvantiteetin tunnistustaidossa, osallistuivat tietokonepohjaiseen kvantiteettipeli-interventioon. Tunnistustaito mitattiin jakson aikana seitsemän kertaa, ja kielelliset ja kognitiiviset taidot alku-, loppu- ja seurantamittauksessa. Venäjänkielisen lapsen tunnistustaito sekä kvantiteetin yleinen erottelutaito paranivat heti harjoittelun myötä. Myös kvantiteetin luku- ja oikeinkirjoitustarkkuus, foneemien ja grafeemien tuntemus ja fonologinen tietoisuus parantuivat. Lukuja kirjoitushäiriöisellä lapsella tunnistustaito parantui…

Children at risk for dyslexia show deficient left-hemispheric memory representations for new spoken word forms

2021

Developmental dyslexia is a specific learning disorder with impairments in reading and spelling acquisition. Apart from literacy problems, dyslexics show inefficient speech encoding and deficient novel word learning, with underlying problems in phonological processing and learning. These problems have been suggested to be related to deficient specialization of the left hemisphere for language processing. To examine this possibility, we tracked with magnetoencephalography (MEG) the activation of the bilateral temporal cortices during formation of neural memory traces for new spoken word forms in 7–8-year-old children with high familial dyslexia risk and in controls. The at-risk children impr…

Brain sensitivity to print emerges when children learn letter-speech sound correspondences

2010

The acquisition of reading skills is a major landmark process in a human’s cognitive development. On the neural level, a new functional network develops during this time, as children typically learn to associate the well-known sounds of their spoken language with unfamiliar characters in alphabetic languages and finally access the meaning of written words, allowing for later reading. A critical component of the mature reading network located in the left occipitotemporal cortex, termed the “visual word-form system” (VWFS), exhibits print-sensitive activation in readers. When and how the sensitivity of the VWFS to print comes about remains an open question. In this study, we demonstrate the i…

Parental literacy predicts children’s literacy: A longitudinal family-risk study

2011

This family-risk (FR) study examined whether the literacy skills of parents with dyslexia are predictive of the literacy skills of their offspring. We report data from 31 child–parent dyads where both had dyslexia (FR-D) and 68 dyads where the child did not have dyslexia (FR-ND). Findings supported the differences in liability of FR children with and without dyslexia: the parents of the FR-D children had more severe difficulties in pseudoword reading and spelling accuracy, in rapid word recognition, and in text reading fluency than the parents of the FR-ND children. Finally, parental skills were found to be significant predictors of children's Grade 3 reading and spelling. Parental skills p…

A computer‐based Pinyin intervention for disadvantaged children in China : Effects on Pinyin skills, phonological awareness, and character reading

2020

Pinyin is an alphabetic script that denotes pronunciations of Chinese characters. Studies have shown that Pinyin instruction enhances both phonological awareness (e.g., Shu et al., Developmental Science, 2008, 11, 171–181) and character reading (e.g., Lin et al., Psychological Science, 2010, 21, 1117–1122) in Chinese children. In the present study, we provided a 3‐week Pinyin intervention with a computer‐based Pinyin GraphoGame to disadvantaged migrant children with poor Pinyin skills. A total of 252 first graders who were children of migrant workers in a large Chinese city were assessed to identify poor Pinyin readers. Fifty‐six 7‐year‐old children with poor Pinyin skills were selected and…

Literacy Skill Development of Children With Familial Risk for Dyslexia Through Grades 2, 3, and 8

2015

This study followed the development of reading speed, reading accuracy, and spelling in transparent Finnish orthography through Grades 2, 3, and 8. We compared two groups of children with familial risk for dyslexia, with or without dyslexia in Grade 2 (Dys_FR, n = 35 and NoDys_FR, n = 66) to a group of children without familial risk and dyslexia (Controls, n = 72). The Dys_FR group showed persisting deficiency especially in reading speed, and, to a minor extent, in reading and spelling accuracy. The Dys_FR children, contrary to the other two groups, relied heavily on letter-by-letter decoding in Grades 2 and 3. In children not fulfilling the criteria for dyslexia in Grade 2, the familial ri…

Predicting delayed letter name knowledge and its relation to grade 1 reading achievement in children with and without familial risk for dyslexia

2006

The authors examined the developmental trajectories of children's early letter knowledge in relation to measures spanning and encompassing their prior language-related and cognitive measures and environmental factors and their subsequent Grade 1 reading achievement. Letter knowledge was assessed longitudinally at ages 4.5, 5.0, 5.5, and 6.5 years; earlier language skills and environmental factors were assessed at ages 3.5 and 4.5 years; and reading achievement was assessed at the beginning and end of Grade 1. The analyses were conducted on a longitudinal data set involving children with and without familial risk for dyslexia. Emerging from the trajectory analysis of letter knowledge were 3 …

Unveiling the Mysteries of Dyslexia : Lessons Learned from the Prospective Jyväskylä Longitudinal Study of Dyslexia

2021

This paper reviews the observations of the Jyväskylä Longitudinal Study of Dyslexia (JLD). The JLD is a prospective family risk study in which the development of children with familial risk for dyslexia (N = 108) due to parental dyslexia and controls without dyslexia risk (N = 92) were followed from birth to adulthood. The JLD revealed that the likelihood of at-risk children performing poorly in reading and spelling tasks was fourfold compared to the controls. Auditory insensitivity of newborns observed during the first week of life using brain event-related potentials (ERPs) was shown to be the first precursor of dyslexia. ERPs measured at six months of age related to phoneme length identi…

Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia

2021

Developmental dyslexia (DD) is a learning disorder affecting the ability to read, with a heritability of 40–60%. A notable part of this heritability remains unexplained, and large genetic studies are warranted to identify new susceptibility genes and clarify the genetic bases of dyslexia. We carried out a genome-wide association study (GWAS) on 2274 dyslexia cases and 6272 controls, testing associations at the single variant, gene, and pathway level, and estimating heritability using single-nucleotide polymorphism (SNP) data. We also calculated polygenic scores (PGSs) based on large-scale GWAS data for different neuropsychiatric disorders and cortical brain measures, educational attainment,…

Dyslexia : early Identification and Prevention: Highlights from the Jyväskylä Longitudinal Study of Dyslexia

2015

Over two decades of Finnish research, monitoring children born with risk for dyslexia has been carried out in the Jyväskylä Longitudinal Study of Dyslexia (JLD). Two hundred children, half at risk, have been assessed from birth to puberty on hundreds of measures. The aims were to identify measures of prediction of later reading difficulty and to instigate appropriate and earliest diagnosis and intervention. We can identify at-risk children from newborn electroencephalographic brain recordings (Guttorm et al., J Neural Transm 110:1059–1074, 2003). Predictors are also apparent from late-talking infants who have familial background of dyslexia (Lyytinen and Lyytinen, Appl Psycolinguistics 25:3…

Guest Editors' Introduction: Supporting Urgent Basic Reading Skills in Children in Africa and Around the World

2014

Sublexical effects on eye movements during repeated reading of words and pseudowords in Finnish

2011

The role of different orthographic units (letters, syllables, words) in reading of orthographically transparent Finnish language was studied by independently manipulating the number of letters (NoL) and syllables (NoS) in words and pseudowords and by recording eye movements during repeated reading aloud of these items. Fluent adult readers showed evidence for using larger orthographic units in (pseudo)word recoding, whereas dysfluent children seem to be stuck in a letter-based decoding strategy, as lexicality and item repetition decreased the NoL effect only among adult readers. The NoS manipulation produced weak repetition effects in both groups. However, dysfluent children showed evidence…

Hilbert-Huang versus morlet wavelet transformation on mismatch negativity of children in uninterrupted sound paradigm

2009

Background. Compared to the waveform or spectrum analysis of event-related potentials (ERPs), time-frequency representation (TFR) has the advantage of revealing the ERPs time and frequency domain information simultaneously. As the human brain could be modeled as a complicated nonlinear system, it is interesting from the view of psychological knowledge to study the performance of the nonlinear and linear time-frequency representation methods for ERP research. In this study Hilbert-Huang transformation (HHT) and Morlet wavelet transformation (MWT) were performed on mismatch negativity (MMN) of children. Participants were 102 children aged 8&#8211;16 years. MMN was elicited in a passive oddbal…