showing 36 of ~574560 from 574555 documents
Determining the potential impacts of fire and different land uses on splash erosion in the margins of drylands
2021
Abstract This research aimed to estimate the splash erosion and its evolution during the first months in specific land uses after a forest fire. The study area was located in Congosto (North-West Spain), in the margins of Spanish drylands, after a wildfire occurred in May 2012, which burned 15.56 ha of scrubland and Pinus reforestation. Two different burned land uses were selected and compared to control areas: i) burned pine forest; and, scrublands. Rainfall intensity and the number, sizes and speed of raindrops were measured by an optical disdrometer and soil loss by funnels. Moreover, infiltration, soil moisture content, aggregate stability, water repellence, pH and organic matter were a…
Emerging Therapies in Immune Thrombocytopenia
2021
Immune thrombocytopenia (ITP) is a rare autoimmune disorder caused by peripheral platelet destruction and inappropriate bone marrow production. The management of ITP is based on the utilization of steroids, intravenous immunoglobulins, rituximab, thrombopoietin receptor agonists (TPO-RAs), immunosuppressants and splenectomy. Recent advances in the understanding of its pathogenesis have opened new fields of therapeutic interventions. The phagocytosis of platelets by splenic macrophages could be inhibited by spleen tyrosine kinase (Syk) or Bruton tyrosine kinase (BTK) inhibitors. The clearance of antiplatelet antibodies could be accelerated by blocking the neonatal Fc receptor (FcRn), while n…
Efficacy of methylprednisolone on pain, trismus and quality of life following surgical removal of mandibular third molars: a double-blind, split-mout…
2021
Background The objective of the present study was to compare the efficacy of different doses of methylprednisolone on postoperative sequelae and quality of life (QoL) following surgical removal of mandibular third molars (SRM3). Material and Methods Fifty-two patients (16 men and 36 women, mean age 25.9 years, range: 18-39) with bilateral impacted mandibular third molars were randomly allocated into intraoperative muscular injection of either 20mg, 30mg, 40mg methylprednisolone or saline injection. Baseline measurements were obtained preoperatively and compared with assessment after one day, three days, seven days and one month. Pain and trismus were estimated by visual analog scale score a…
From Bi-Dimensionality to Uni-Dimensionality in Self-Report Questionnaires
2021
Abstract. The common factor model – by far the most widely used model for factor analysis – assumes equal item intercepts across respondents. Due to idiosyncratic ways of understanding and answering items of a questionnaire, this assumption is often violated, leading to an underestimation of model fit. Maydeu-Olivares and Coffman (2006) suggested the introduction of a random intercept into the model to address this concern. The present study applies this method to six established instruments (measuring depression, procrastination, optimism, self-esteem, core self-evaluations, and self-regulation) with ambiguous factor structures, using data from representative general population samples. I…
Deep and Meaningful E-Learning with Social Virtual Reality Environments in Higher Education: A Systematic Literature Review
2021
Deep and meaningful learning (DML) in distant education should be an essential outcome of quality education. In this literature review, we focus on e-learning effectiveness along with the factors and conditions leading to DML when using social virtual reality environments (SVREs) in distance mode higher education (HE). Hence, a systematic literature review was conducted summarizing the findings from thirty-three empirical studies in HE between 2004 (appearance of VR) and 2019 (before coronavirus appearance). We searched for the cognitive, social, and affective aspects of DML in a research framework and studied their weight in SVREs. The findings suggest that the use of SVREs can provide aut…
Ropeginterferon alfa-2b versus phlebotomy in low-risk patients with polycythaemia vera (Low-PV study): a multicentre, randomised phase 2 trial.
2021
Summary Background There is no evidence that phlebotomy alone is sufficient to steadily maintain haematocrit on target level in low-risk patients with polycythaemia vera. This study aimed to compare the efficacy and safety of ropeginterferon alfa-2b on top of the standard phlebotomy regimen with phlebotomy alone. Methods In 2017, we launched the Low-PV study, a multicentre, open-label, two-arm, parallel-group, investigator-initiated, phase 2 randomised trial with a group-sequential adaptive design. The study involved 21 haematological centres across Italy. Participants were recruited in a consecutive order. Participants enrolled in the study were patients, aged 18–60 years, with a diagnosis…
Differences in the Psychological Profiles of Elite and Non-elite Athletes.
2021
One of the main goals of sport psychology is to identify those psychological factors that are relevant for sport performance as well as possibilities of their development. The aim of the study was to determine whether the set of specific psychological characteristics [generalized self-efficacy, time perspective, emotional intelligence (EI), general achievement motivation, and personality dimensions] makes the distinction between athletes based on their (non)-participation in the senior national team, that is, their belonging to the subsample of elite or non-elite athletes depending on this criterion. According to the group centroids it can be said that elite athletes are characterized by a …
The impact of quantitative easing on UK bank lending: Why banks do not lend to businesses?
2021
Abstract The growing proportion of UK bank lending to the financial sector reached a peak in 2007 just before the onset of the Global Financial Crisis (GFC). This marks a trend in the dwindling amount of bank lending to private sector non-financial corporations (PNFCs), which was exacerbated with the Great Recession. Many central banks aimed to revive bank lending with quantitative easing (QE) and unconventional monetary policy. We propose an agent based computational economics (ACE) model which combines the main factors in the economic environment of QE and Basel regulatory framework to analyse why UK banks do not prioritize lending to non-financial businesses. The lower bond yields caused…
On multiplicities of cocharacters for algebras with superinvolution
2021
Abstract In this paper we deal with finitely generated superalgebras with superinvolution, satisfying a non-trivial identity, whose multiplicities of the cocharacters are bounded by a constant. Along the way, we prove that the codimension sequence of such algebras is polynomially bounded if and only if their colength sequence is bounded by a constant.
Platelet Phenotyping and Function Testing in Thrombocytopenia.
2021
Patients who suffer from inherited or acquired thrombocytopenia can be also affected by platelet function defects, which potentially increase the risk of severe and life-threatening bleeding complications. A plethora of tests and assays for platelet phenotyping and function analysis are available, which are, in part, feasible in clinical practice due to adequate point-of-care qualities. However, most of them are time-consuming, require experienced and skilled personnel for platelet handling and processing, and are therefore well-established only in specialized laboratories. This review summarizes major indications, methods/assays for platelet phenotyping, and in vitro function testing in bl…
Validity of Brief Scales for Assessing Transdiagnostic Cognitive Emotion Regulation Strategies in Primary Care Patients With Emotional Disorders
2021
Abstract. Cognitive emotion regulation strategies have been proposed as an explanation for transdiagnostic vulnerability to emotional disorders, which are highly prevalent in the primary care setting. The use of brief psychological instruments to detect cognitive-emotional factors – such as worry, rumination, interpretative and attentional distortions, and metacognitions – could provide valuable clinical data to better guide treatment in primary care. The aim of the present study was to evaluate the psychometric properties of four brief scales derived from the full versions of four assessment instruments (PSWQ, RRS, IACTA, and MCQ-30). The brief scales were completed by 1,250 primary care …
Problem solving: competence for the enhancement of talents. A research with future primary school and kindergarten support teachers
2021
Education to achieve individual talent must become a priority in the educational process in order to contribute to the construction of a sustainable society. Training teachers to promote talent in students means guaranteeing each person the educational success and the achievement of their maximum potential. If problem solving becomes a tool for the enhancement of talent in the classroom, training in this competence becomes essential. In the educational field, talent and excellence are based on a unique attitude or an accentuated interest that a person possesses. The topic of the ability to solve educational problems by those who are going to carry out the profession of teacher implies the a…
Ecografía intestinal y abdomen agudo: más allá de la apendicitis aguda
2021
Resumen El abdomen agudo es un motivo de consulta habitual en los servicios de urgencias. Sus causas son multiples, y entre ellas se encuentran diversas enfermedades del tracto gastrointestinal. Si bien la tomografia computarizada es la tecnica mas aceptada, con frecuencia se lleva a cabo una ecografia abdominal inicialmente, mediante la cual es posible establecer la sospecha de patologia intestinal. Este articulo describe las caracteristicas ecograficas de diversos trastornos intestinales que cursan con abdomen agudo, como la diverticulitis aguda, la obstruccion intestinal, la perforacion gastrointestinal, la isquemia intestinal, la necrosis aguda de la grasa intraabdominal y una miscelane…
Anodizing and post-anodizing processes to enhance corrosion resistance of Al alloys
2021
In this work the dependence of corrosion resistance of Al alloys AA 2024-T3 on sealing treatments was studied. AA 2024-T3 samples were anodized at 14 V in a bath containing sulfuric and tartaric acids. Anodized samples were sealed with four different treatments: hot water, vapour, hot water with salts and stirred hot water. Electrochemical Impedance Spectroscopy measurements were performed to estimate samples' corrosion resistance in a solution simulating sea water environment. Samples sealed in hot water showed the highest corrosion resistance.
How much is enough? : The convergence of finite sample scattering properties to those of infinite media
2021
We study the scattering properties of a cloud of particles. The particles are spherical, close to the incident wavelength in size, have a high albedo, and are randomly packed to 20% volume density. We show, using both numerically exact methods for solving the Maxwell equations and radiative-transfer-approximation methods, that the scattering properties of the cloud converge after about ten million particles in the system. After that, the backward-scattered properties of the system should estimate the properties of a macroscopic, practically infinite system. (C) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.o…
Taxer les machines ? Trois pétitions de travailleurs au Parlement britannique (1830-1833)
2021
International audience
Buckling strength of steel tube for lifting telescopic wind steel tower
2021
Abstract A telescopic pole for wind energy production with low environmental impact and its lifting system for a 60–250 kW turbine and a height of 30 m have been designed and manufactured. The tower, was raised and lowered by automation or by remote control, that allows one to differentiate the presence of the generator within the landscape over time. The jacking systems acting on the legs had a combination of holes (on the legs) and pegs actuated by hydraulic pistons. The aim of the paper was the experimental and the analytical verification of the stability condition of the steel piston as a lifting system of the prototype. An experimental investigation was carried out on small-scale speci…
Factores de predicción de dosificación inadecuada de rivaroxabán utilizando la ecuación de CKD-EPI
2021
Yes
Les stages en alternance au master éducation physique : quels apprentissages pour les étudiants ?
2021
International audience
New Laboratory Protocol to Determine the Oxidative Stress Profile of Human Nasal Epithelial Cells Using Flow Cytometry
2021
Several studies have shown the importance of oxidative stress (OS) in respiratory disease pathogenesis. It has been reported that the nasal epithelium may act as a surrogate for the bronchial epithelium in several respiratory diseases involving OS. However, the sample yields obtained from nasal biopsies are modest, limiting the number of parameters that can be determined. Flow cytometry has been widely used to evaluate cellular OS profiles. It has the advantage that analyses can be performed using a small amount of sample. Therefore, we aimed to set up a new method based on flow cytometry to assess the oxidative profile of human nasal epithelial cells which could be used in research on resp…
A methodology to estimate forest fires burned areas and burn severity degrees using Sentinel-2 data. Application to the October 2017 fires in the Ibe…
2021
Abstract A methodology to estimate the extent of areas affected by forest fires, as well as the burn severity levels using Sentinel 2 images (10 and 20 m) is proposed and applied to the fires occurred in October 2017 in Spain and Portugal. An extension larger than 250,000 ha and 4 burn severity levels (low, moderate, high and very high) have been obtained. The comparison with the European Forest Fire Information System (EFFIS), which uses MODIS images (250 m), shows that the methodology improves the area estimate by 10 % in commission area. In terms of burn severity levels, the Separability index (SI) and the Kappa statistic (k) show a high correlation between Sentinel-2 and EFFIS (SI value…
Filling the Gap in the Metallacrown Family: The 9‐MC‐3 Chromium Metallacrown
2021
Abstract In this work, we report on a long‐sought missing complex in the metallacrown family. We synthesized and characterized the novel chromium metallacrown (MC) complex {CrIII(μ 2‐piv)3[9‐MCCr(III)N(shi)‐3](morph)3}⋅MeOH (in which shi3−=salicyl hydroxamate, piv=pivalate, and morph=morpholine). The MC with a 9‐MC‐3 cavity of kinetically inert chromium(III) ions was synthesized by a solvothermal reaction. Magnetization measurements reveal a high spin ground state.
Active north-vergent thrusting in the northern Sicily continental margin in the frame of the quaternary evolution of the Sicilian collisional system
2021
Abstract A three-stage evolution has characterized the Sicilian Fold and Thrust Belt (SFTB) during the last 15 My: two main thin-skinned shortening events involving mainly Meso-Cenozoic carbonate units, followed by thick-skinned thrusting involving Plio-Pleistocene deposits in the frontal area as well as the crystalline basement in the inner and deeper sector of the chain. We investigated the northern Sicily continental margin, by using differently-penetrative seismic reflection data and new field surveys, which revealed, both offshore and onshore, north-vergent compressional structures that affected the tectonic edifice during Quaternary time. These structures, correlated with the kinemati…
Alterazioni dell’emodinamica intrarenale e del microcircolo coroideo valutate mediante OCT in soggetti con ipertensione arteriosa
2021
GSE4-loaded nanoparticles a potential therapy for lung fibrosis that enhances pneumocyte growth, reduces apoptosis and DNA damage.
2021
© 2021 The Authors.
Fortellinger om gutters krise, jenters fremgang og skolens utfordringer med sosiale ulikheter
2021
Gutter som skolens tapere er blitt en dominerende fortelling gjennom mange år og gjentas nok en gang gjennom Stoltenbergutvalgets rapport om kjønnsforskjellene i skolen. Fortellingen bygger på en dikotomisk kjønnsforståelse og ikke en forståelse av at kjønn er mangfoldig og konstrueres kontinuerlig i kulturelle, sosiale og språklige sammenhenger. Ved å betrakte gutter som skolens tapere som et dominerende narrativ belyser jeg premissene for en slik fortelling, konsekvensene den har og hvilke fortellinger som usynliggjøres eller stilles i skyggen – fortellinger om en skole som ikke evner å utjevne de sosiale ulikhetene den har et mål om å utjevne.
Thermal response test analysis for U-pipe vertical borehole heat exchangers under groundwater flow conditions
2021
[EN] Conventional models used in the analysis of thermal response test data only consider conduction as heat transfer mechanism. In cases where presence of groundwater is detected, convection heat transmission plays an important role, so its influence must be determined in the calculation of the effective thermal conductivity, usually overestimated in these situations, increasing its value the higher the power injected and the time elapsed. In this work, based on the data collected in a borehole located at UPV (Valencia) in which have been carried out three thermal response tests with different characteristics, has been implemented a variation of the finite line source model introducing an …
“I feel, I know, I am immortal”: literary works in the newspapers of Soviet prisons and camps in the 1920s
2021
Abstract The present article sheds new light on the newspapers and other publications of the Soviet prison camps in the 1920s and early 1930s. The first part reconstructs the institutional dynamics that brought about the publication of newspapers, wall newspapers and other periodicals produced inside the camps. The article then focuses on a selection of literary works published by inmates and on the importance of Soviet newspapers published in places of detention as a source for the study not only of the history of the Gulag, but also of its culture and literature.
Interleukin 1α: a comprehensive review on the role of IL-1α in the pathogenesis and treatment of autoimmune and inflammatory diseases.
2021
Abstract The interleukin (IL)-1 family member IL-1α is a ubiquitous and pivotal pro-inflammatory cytokine. The IL-1α precursor is constitutively present in nearly all cell types in health, but is released upon necrotic cell death as a bioactive mediator. IL-1α is also expressed by infiltrating myeloid cells within injured tissues. The cytokine binds the IL-1 receptor 1 (IL-1R1), as does IL-1β, and induces the same pro-inflammatory effects. Being a bioactive precursor released upon tissue damage and necrotic cell death, IL-1α is central to the pathogenesis of numerous conditions characterized by organ or tissue inflammation. These include conditions affecting the lung and respiratory tract, …
16P How to translate what we learned from Gaucher’s disease into new treatments for brain tumours
2021
Phase III Trial of Avelumab Maintenance After First-Line Induction Chemotherapy Versus Continuation of Chemotherapy in Patients With Gastric Cancers:…
2021
PURPOSE The role of maintenance therapy for gastric (GC) or gastroesophageal junction cancer (GEJC) is unclear. We investigated avelumab (anti–programmed death ligand-1 [PD-L1]) maintenance after first-line induction chemotherapy for GC/GEJC. PATIENTS AND METHODS JAVELIN Gastric 100 was a global, open-label, phase III trial. Eligible patients had untreated, unresectable, human epidermal growth factor receptor 2–negative, locally advanced or metastatic GC or GEJC. Patients without progressive disease after 12 weeks of first-line chemotherapy with oxaliplatin plus a fluoropyrimidine were randomly assigned 1:1 to avelumab 10 mg/kg every 2 weeks or continued chemotherapy, stratified by region (…
Second-line Eribulin in Triple Negative Metastatic Breast Cancer patients. Multicentre Retrospective Study: The TETRIS Trial
2021
Introduction: Large and consistent evidence supports the use of eribulin mesylate in clinical practice in third or later line treatment of metastatic triple negative breast cancer (mTNBC). Conversely, there is paucity of data on eribulin efficacy in second line treatment. Methods: We investigated outcomes of 44 mTNBC patients treated from 2013 through 2019 with second line eribulin mesylate in a multicentre retrospective study involving 14 Italian oncologic centres. Results: Median age was 51 years, with 11.4% of these patients being metastatic at diagnosis. Median overall survival (OS) and progression free survival (PFS) from eribulin starting were 11.9 (95%CI: 8.4-15.5) and 3.5 months (95…
Computing oscillatory solutions of the Euler system via 𝒦-convergence
2021
We develop a method to compute effectively the Young measures associated to sequences of numerical solutions of the compressible Euler system. Our approach is based on the concept of [Formula: see text]-convergence adapted to sequences of parameterized measures. The convergence is strong in space and time (a.e. pointwise or in certain [Formula: see text] spaces) whereas the measures converge narrowly or in the Wasserstein distance to the corresponding limit.
Automated Patch Assessment for Program Repair at Scale
2021
AbstractIn this paper, we do automatic correctness assessment for patches generated by program repair systems. We consider the human-written patch as ground truth oracle and randomly generate tests based on it, a technique proposed by Shamshiri et al., called Random testing with Ground Truth (RGT) in this paper. We build a curated dataset of 638 patches for Defects4J generated by 14 state-of-the-art repair systems, we evaluate automated patch assessment on this dataset. The results of this study are novel and significant: First, we improve the state of the art performance of automatic patch assessment with RGT by 190% by improving the oracle; Second, we show that RGT is reliable enough to h…
Morphometric analysis of cardiac conduction fibers in horses and dogs, a comparative histological and immunohistochemical study with findings in huma…
2021
Abstract The principal function of the ventricular conduction system is rapid electrical activation of the ventricles. The aim of this study is to conduct a morphometric study to pinpoint the morphological parameters that define cardiac conduction cells, allowing us to distinguish them from other cells. Five male horse hearts and five male dog hearts were used in the study. The hearts were fixed in a 5% formaldehyde solution. Histological sections of 5 μm thickness were acquired and stained with hematoxylin-eosin and Masson's trichrome and cardiac conduction cells and their junctions were identified by desmin, connexin 40 and a PAS method. We found statistically significant differences in c…