showing 36 of ~574560 from 574555 documents
NT3/TrkC Pathway Modulates the Expression of UCP-1 and Adipocyte Size in Human and Rodent Adipose Tissue
2021
Neurotrophin-3 (NT3), through activation of its tropomyosin-related kinase receptor C (TrkC), modulates neuronal survival and neural stem cell differentiation. It is widely distributed in peripheral tissues (especially vessels and pancreas) and this ubiquitous pattern suggests a role for NT3, outside the nervous system and related to metabolic functions. The presence of the NT3/TrkC pathway in the adipose tissue (AT) has never been investigated. Present work studies in human and murine adipose tissue (AT) the presence of elements of the NT3/TrkC pathway and its role on lipolysis and adipocyte differentiation. qRT-PCR and immunoblot indicate that NT3 (encoded by NTF3) was present in human re…
Active north-vergent thrusting in the northern Sicily continental margin in the frame of the quaternary evolution of the Sicilian collisional system
2021
Abstract A three-stage evolution has characterized the Sicilian Fold and Thrust Belt (SFTB) during the last 15 My: two main thin-skinned shortening events involving mainly Meso-Cenozoic carbonate units, followed by thick-skinned thrusting involving Plio-Pleistocene deposits in the frontal area as well as the crystalline basement in the inner and deeper sector of the chain. We investigated the northern Sicily continental margin, by using differently-penetrative seismic reflection data and new field surveys, which revealed, both offshore and onshore, north-vergent compressional structures that affected the tectonic edifice during Quaternary time. These structures, correlated with the kinemati…
Fortellinger om gutters krise, jenters fremgang og skolens utfordringer med sosiale ulikheter
2021
Gutter som skolens tapere er blitt en dominerende fortelling gjennom mange år og gjentas nok en gang gjennom Stoltenbergutvalgets rapport om kjønnsforskjellene i skolen. Fortellingen bygger på en dikotomisk kjønnsforståelse og ikke en forståelse av at kjønn er mangfoldig og konstrueres kontinuerlig i kulturelle, sosiale og språklige sammenhenger. Ved å betrakte gutter som skolens tapere som et dominerende narrativ belyser jeg premissene for en slik fortelling, konsekvensene den har og hvilke fortellinger som usynliggjøres eller stilles i skyggen – fortellinger om en skole som ikke evner å utjevne de sosiale ulikhetene den har et mål om å utjevne.
Improved active fiber-based retroreflector with intensity stabilization and a polarization monitor for the near UV.
2021
We present an improved active fiber-based retroreflector (AFR) providing high-quality wavefront-retracing anti-parallel laser beams in the near UV. We use our improved AFR for first-order Doppler-shift suppression in precision spectroscopy of atomic hydrogen, but our setup can be adapted to other applications where wavefront-retracing beams with defined laser polarization are important. We demonstrate how weak aberrations produced by the fiber collimator may remain unobserved in the intensity of the collimated beam but limit the performance of the AFR. Our general results on characterizing these aberrations with a caustic measurement can be applied to any system where a collimated high-qual…
“I feel, I know, I am immortal”: literary works in the newspapers of Soviet prisons and camps in the 1920s
2021
Abstract The present article sheds new light on the newspapers and other publications of the Soviet prison camps in the 1920s and early 1930s. The first part reconstructs the institutional dynamics that brought about the publication of newspapers, wall newspapers and other periodicals produced inside the camps. The article then focuses on a selection of literary works published by inmates and on the importance of Soviet newspapers published in places of detention as a source for the study not only of the history of the Gulag, but also of its culture and literature.
Interleukin 1α: a comprehensive review on the role of IL-1α in the pathogenesis and treatment of autoimmune and inflammatory diseases.
2021
Abstract The interleukin (IL)-1 family member IL-1α is a ubiquitous and pivotal pro-inflammatory cytokine. The IL-1α precursor is constitutively present in nearly all cell types in health, but is released upon necrotic cell death as a bioactive mediator. IL-1α is also expressed by infiltrating myeloid cells within injured tissues. The cytokine binds the IL-1 receptor 1 (IL-1R1), as does IL-1β, and induces the same pro-inflammatory effects. Being a bioactive precursor released upon tissue damage and necrotic cell death, IL-1α is central to the pathogenesis of numerous conditions characterized by organ or tissue inflammation. These include conditions affecting the lung and respiratory tract, …
Phase III Trial of Avelumab Maintenance After First-Line Induction Chemotherapy Versus Continuation of Chemotherapy in Patients With Gastric Cancers:…
2021
PURPOSE The role of maintenance therapy for gastric (GC) or gastroesophageal junction cancer (GEJC) is unclear. We investigated avelumab (anti–programmed death ligand-1 [PD-L1]) maintenance after first-line induction chemotherapy for GC/GEJC. PATIENTS AND METHODS JAVELIN Gastric 100 was a global, open-label, phase III trial. Eligible patients had untreated, unresectable, human epidermal growth factor receptor 2–negative, locally advanced or metastatic GC or GEJC. Patients without progressive disease after 12 weeks of first-line chemotherapy with oxaliplatin plus a fluoropyrimidine were randomly assigned 1:1 to avelumab 10 mg/kg every 2 weeks or continued chemotherapy, stratified by region (…
Empirical Study on Cyber Range Capabilities, Interactions and Learning Features
2021
Emerging technologies and the globalization require constant investment in people and their performance in actual and virtual environments. New technologies such as autonomous systems, machine learning and artificial intelligence (AI) radically re-contextualize the human dimension of the organization. Technological developments are changing the ways people experience the physical and the virtual environments. Strategic changes have revealed new critical vulnerabilities such as social media-based disinformation campaigning with impact on the human aspects at state, societal, organizational and individual levels. Scenarios of gathering information, committing fraud or getting access to critic…
Synthesis, X-Ray Structure, Tautomerism Aspect, and Chemical Insight of The 3-(1H-Indol-2-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-ol
2021
The 3-(1H-indol-2-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-ol 2 was obtained exclusively in the enol configuration starting from triazolyl-indole derivative 1 and alkyl halo-esters in the presence of K2CO3. Chemical structure elucidations with the aid of physicochemical characterizations were used to predict its molecular structure while single crystal X-ray diffraction technique was used to shed the light on the supramolecular structure of 2. DFT calculations agreed very well with the reported X-ray structure where the most stable form thermodynamically is the enol form. Its optimized geometry agreed very well with the experimental structure where the correlation coefficients betwe…
Laparoscopic Appendectomy Versus Open Appendectomy in Children: Evolution over Time
2021
Abstract Laparoscopic appendicitis surgery is accepted in more and more centers around the world. Studies and meta-analyses of studies have shown that laparoscopic appendicitis is a feasible and safe procedure with numerous clinical benefits, such as shorter postoperative ileus, lower incidence of wound infection, lower postoperative pain and duration, recurrence faster to activities. Because laparoscopic appendectomy has been associated with a reduced risk of surgical complications, it may provide a better alternative versus open surgery. A review of data relevant to the evaluation of laparoscopic appendectomy versus open appendectomy as reflected in the literature of the last 2 decades wo…
Habilidades matemáticas tempranas en niños chilenos con Trastorno del Desarrollo del Lenguaje: Un estudio comparativo
2021
En las últimas décadas se ha incrementado el interés de las investigaciones respecto a las dificultades académicas que presentan los niños con Trastorno del Desarrollo del Lenguaje (TDL). No obstante, su relación con las habilidades matemáticas es una de las menos estudiadas. El objetivo de este estudio consistió en determinar si existen diferencias relevantes entre las habilidades matemáticas tempranas de niños con TDL y con desarrollo típico (DT). Participaron 78 niños de 4 a 7 años 11 meses de edad, pertenecientes a colegios con programas de integración escolar de Santiago de Chile. Se conformó un grupo de 44 niños con TDL y un grupo de 34 con DT. Se establecieron comparaciones del rendi…
Changes in air pollution during COVID-19 lockdown in Spain: a multi-city study
2021
Highlights • Variations in air quality in terms of CO, SO2, PM10, O3 and NO2 levels were studied • The lockdown of Spain was not able to reduce severe air pollution in all its forms • Significant reductions of NO2 levels were achieved in most cities • Increases of O3 pollution levels were found in several cities
Automated Patch Assessment for Program Repair at Scale
2021
AbstractIn this paper, we do automatic correctness assessment for patches generated by program repair systems. We consider the human-written patch as ground truth oracle and randomly generate tests based on it, a technique proposed by Shamshiri et al., called Random testing with Ground Truth (RGT) in this paper. We build a curated dataset of 638 patches for Defects4J generated by 14 state-of-the-art repair systems, we evaluate automated patch assessment on this dataset. The results of this study are novel and significant: First, we improve the state of the art performance of automatic patch assessment with RGT by 190% by improving the oracle; Second, we show that RGT is reliable enough to h…
Type 1 Diabetes and Autoimmune Thyroid Disease—The Genetic Link
2021
Type 1 diabetes (T1D) and autoimmune thyroid disease (AITD) are the most frequent chronic autoimmune diseases worldwide. Several autoimmune endocrine and non-endocrine disorders tend to occur together. T1D and AITD often cluster in individuals and families, seen in the formation of autoimmune polyendocrinopathy (AP). The close relationship between these two diseases is largely explained by sharing a common genetic background. The HLA antigens DQ2 (DQA1*0501-DQB1*0201) and DQ8 (DQA1*0301-DQB1*0302), tightly linked with DR3 and DR4, are the major common genetic predisposition. Moreover, functional single nucleotide polymorphisms (or rare variants) of various genes, such as the cytotoxic T-lym…
Perfil de sensibilidad antibiótica de Raoultella spp. en la Comunidad Valenciana: resultados de la Red de Vigilancia Microbiológica durante un períod…
2021
Second-line Eribulin in Triple Negative Metastatic Breast Cancer patients. Multicentre Retrospective Study: The TETRIS Trial
2021
Introduction: Large and consistent evidence supports the use of eribulin mesylate in clinical practice in third or later line treatment of metastatic triple negative breast cancer (mTNBC). Conversely, there is paucity of data on eribulin efficacy in second line treatment. Methods: We investigated outcomes of 44 mTNBC patients treated from 2013 through 2019 with second line eribulin mesylate in a multicentre retrospective study involving 14 Italian oncologic centres. Results: Median age was 51 years, with 11.4% of these patients being metastatic at diagnosis. Median overall survival (OS) and progression free survival (PFS) from eribulin starting were 11.9 (95%CI: 8.4-15.5) and 3.5 months (95…
Morphometric analysis of cardiac conduction fibers in horses and dogs, a comparative histological and immunohistochemical study with findings in huma…
2021
Abstract The principal function of the ventricular conduction system is rapid electrical activation of the ventricles. The aim of this study is to conduct a morphometric study to pinpoint the morphological parameters that define cardiac conduction cells, allowing us to distinguish them from other cells. Five male horse hearts and five male dog hearts were used in the study. The hearts were fixed in a 5% formaldehyde solution. Histological sections of 5 μm thickness were acquired and stained with hematoxylin-eosin and Masson's trichrome and cardiac conduction cells and their junctions were identified by desmin, connexin 40 and a PAS method. We found statistically significant differences in c…
Reply to: Kow CS et al. Are severe asthma patients at higher risk of developing severe outcomes from COVID-19?
2021
Influence of pillar 3 of pension system on retirement pensions level in Poland : will voluntary part of system enable decent life in old age?
2021
PURPOSE: The aim of this paper is the comparative analysis of the general saving ways included in pillar 3 of the pension system and showing their potential effectiveness from the perspective of the pension system participant. Will the resources allocated by the instruments of the voluntary pension system part significantly improve the level of the future pension? Will they allow a more decent life for an average Polish citizen in the period of the old age?
Superficial Siderosis of the Central Nervous System associated with Hemophilia A: A case report
2021
Abstract Superficial Siderosis of the Central Nervous System (SSCNS) is a condition secondary to the deposition of hemosiderin within the subpial layers of central nervous system leading to its progressive degeneration, clinically responsible for hearing impairment, cerebellar ataxia and pyramidal syndrome. Here we report the case of a 61-year-old man with medical history of congenital hemophilia A presenting with typical clinical features of SSCNS associated with extensive hypo-intensity on fast 2D gradient-echo-weighted sequences, along the spinal cord, posterior fossa's structures and cerebral cortex. Interestingly, although his disorder was revealed by a lumbar spinal stenosis, presurgi…
Literacy and literacy practices: Plurilingual connected migrants and emerging literacy
2021
Abstract Recent migration towards Europe is characterized by the massive presence of adults whose educational paths have been interrupted and who are thus developing literacy for the first time in a new language. A literacy test elaborated at the University of Palermo, Italy, showed that, on a sample of 774 migrants, about 30 percent could not read and/or write short words. This test assessed the learners’ abilities to read and write, whether in the Roman alphabet or in other writing systems, and whether in Italian or in other languages of learners’ repertoires. These learners with emergent literacy mostly came from sub-Saharan Africa, an area characterized by diverse forms of multilinguali…
NUPR1 protects liver from lipotoxic injury by improving the endoplasmic reticulum stress response
2021
AbstractBackground and AimsNon-alcoholic fatty liver disease and related hepatic syndromes affect up to one third of the adult population. The molecular mechanisms underlying NAFL etiology remain elusive. Nuclear Protein 1 (NUPR1) expression increases upon cell injury in all organs and recently we report its active participation in the activation of the Unfolded Protein Response (UPR). The UPR typically maintains protein homeostasis, but downstream mediators of the pathway regulate metabolic functions, including lipid metabolism. NUPR1 and UPR increase have been reported in obesity and liver pathologies and the goal of this study was to investigate the roles of NUPR1 in this context.Methods…
Computational general relativistic force-free electrodynamics
2021
Scientific codes are an indispensable link between theory and experiment; in (astro-)plasma physics, such numerical tools are one window into the universe's most extreme flows of energy. The discretization of Maxwell's equations - needed to make highly magnetized (astro)physical plasma amenable to its numerical modeling - introduces numerical diffusion. It acts as a source of dissipation independent of the system's physical constituents. Understanding the numerical diffusion of scientific codes is the key to classify their reliability. It gives specific limits in which the results of numerical experiments are physical. We aim at quantifying and characterizing the numerical diffusion propert…
On a nonlinear Schrödinger equation for nucleons in one space dimension
2021
We study a 1D nonlinear Schrödinger equation appearing in the description of a particle inside an atomic nucleus. For various nonlinearities, the ground states are discussed and given in explicit form. Their stability is studied numerically via the time evolution of perturbed ground states. In the time evolution of general localized initial data, they are shown to appear in the long time behaviour of certain cases.
Field evaluation of a rapid antigen test (Panbio™ COVID-19 Ag Rapid Test Device) for COVID-19 diagnosis in primary healthcare centres.
2021
Abstract Objectives To our knowledge no previous study has assessed the performance of a rapid antigen diagnostic immunoassay (RAD) conducted at the point of care (POC). We evaluated the Panbio™ COVID-19 Ag Rapid Test Device for diagnosis of coronavirus 2019 disease (COVID-19) in symptomatic patients (n = 412) attending primary healthcare centres. Methods RAD was performed immediately after sampling following the manufacturer's instructions (reading at 15 min). RT-PCRs were carried out within 24 h of specimen collection. Samples displaying discordant results were processed for culture in Vero E6 cells. Presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in cell cultures…
The Eminent Russian – German Chemist Friedrich Konrad Beilstein (1838-1906) in the Literature between the 19th and 21st Centuries
2021
Friedrich Konrad Beilstein (1838-1906) was one of the most prominent chemists of the second half of the nineteenth century. His life and scientific achievements were described in the literature published between the 19th and 21st centuries in different countries. The purpose of this paper is to familiarize readers with the important events in the life of Beilstein and his research activities, in particular some of his experimental research results, as well as his selected publications. In addition, the names of authors of biographies or biographical notes about Beilstein, published in 1890-2018 are presented.
The Sources of Global Administrative Law
2021
International audience; The "Global administrative law" emerged in the United States in the mid-2000s as a research project aimed at observing and promoting the development of administrative-type norms beyond the state: transparency of international decision-making processes, motivation of decisions, emergence of appeals, etc. GAL's doctrine starts from the questionable assumption that classical international law, too stato-centric, would not allow the analysis of these phenomena. In particular, it rejects the notion of the source of law, but retains certain reflexes marked by classicism by excluding multinational companies from the reflection. An analysis of the limits of the GAL has there…
Cardiovascular Risk Factors - Association with Lower Extremity Versus Coronary Artery Disease
2021
Abstract Atherosclerosis is the main cause of lower extremity artery disease (LEAD) and coronary artery disease (CAD). These two arterial territories share the major cardiovascular risk factors: smoking, hypertension, dyslipidaemia and diabetes. Current guidelines draw attention to other possible risk factors: homocysteine level, inflammation markers (e.g. high-sensitive C reactive-protein (CRP), interleukin 6) and chronic kidney disease (CKD.) The objective of this study was to evaluate the cardiovascular risk factors strength association with LEAD and CAD on a study population of 203 patients. Our study concluded that smoking seems to be the most powerful risk factor for LEAD, especially …
An Intra-Subject Approach Based on the Application of HMM to Predict Concentration in Educational Contexts from Nonintrusive Physiological Signals in…
2021
Previous research has proven the strong influence of emotions on student engagement and motivation. Therefore, emotion recognition is becoming very relevant in educational scenarios, but there is no standard method for predicting students’ affects. However, physiological signals have been widely used in educational contexts. Some physiological signals have shown a high accuracy in detecting emotions because they reflect spontaneous affect-related information, which is fresh and does not require additional control or interpretation. Most proposed works use measuring equipment for which applicability in real-world scenarios is limited because of its high cost and intrusiveness. To tackle this…
EFFETTI DELLA DIETA MEDITERRANEA SUGLI INDICI DI DISFUNZIONE ENDOTELIALE, SULL'ESPRESSIONE SIERICA DEI MARKERS ADIPO-INFIAMMATORI E DEL PATTERN CERAM…
2021
Background Le attuali conoscenze evidenziano il ruolo cruciale della dieta mediterranea nella prevenzione delle malattie cardiovascolari. A tal proposito, negli ultimi decenni, diversi studi e alcuni trial randomizzati di intervento dietetico, come lo studio Lyon diet heart study, hanno riportato gli effetti benefici dello stile mediterraneo sulla prevenzione secondaria delle malattie cardiovascolari Lo studio PREDIMED è il primo studio randomizzato su su larga scala che mostra l'impatto significativo della dieta mediterranea come strumento di prevenzione primaria contro eventi cardiovascolari, come ictus, fibrillazione atriale, malattia vascolare periferica e infarto del miocardio. La cera…
Accentuating the Interrelation between Consumer Intention and Healthy Packaged Food Selection during COVID-19: A Case Study of Pakistan
2021
This study contemplates the factors that influence consumer intention, before and during the eruption of COVID-19, for the selection of healthy packaged food in Pakistan. The extant studies have identified two distinct attitudes of consumers about food label information: one is its usefulness and the second elucidates the avoidance. Hence forth, the current study contributes to the extant literature while signifying both reasons which motivate consumers to read food labels and reasons which discourage consumers from consult food labels at the point of purchase. Moreover, the impact of subjective norms and self-efficacy for healthy packaged food intentions has also been examined for both bef…
Button batteries and typical swallowed foreign bodies can be differentiated in high-resolution X-Rays.
2021
Abstract Background Button battery ingestions have emerged as an increasing medical issue in recent years, especially for children. The frequent use of these energy sources in small appliances and toys is responsible for their ubiquitous occurrence in households. In addition to other possible foreign bodies, button batteries are particularly dangerous as they can cause severe complications in the aerodigestive tract. Objective The study aimed for a detailed analysis of specific radiographic identifiers of button batteries and similarly configured potential esophageal foreign bodies in high-resolution X-ray scans. Methods A selection of potentially hazardous button batteries - in cases of in…
Volume preserving mean curvature flows near strictly stable sets in flat torus
2021
In this paper we establish a new stability result for the smooth volume preserving mean curvature flow in flat torus $\mathbb T^n$ in low dimensions $n=3,4$. The result says roughly that if the initial set is near to a strictly stable set in $\mathbb T^n$ in $H^3$-sense, then the corresponding flow has infinite lifetime and converges exponentially fast to a translate of the strictly stable (critical) set in $W^{2,5}$-sense.
How much is enough? : The convergence of finite sample scattering properties to those of infinite media
2021
We study the scattering properties of a cloud of particles. The particles are spherical, close to the incident wavelength in size, have a high albedo, and are randomly packed to 20% volume density. We show, using both numerically exact methods for solving the Maxwell equations and radiative-transfer-approximation methods, that the scattering properties of the cloud converge after about ten million particles in the system. After that, the backward-scattered properties of the system should estimate the properties of a macroscopic, practically infinite system. (C) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.o…
Problem solving: competence for the enhancement of talents. A research with future primary school and kindergarten support teachers
2021
Education to achieve individual talent must become a priority in the educational process in order to contribute to the construction of a sustainable society. Training teachers to promote talent in students means guaranteeing each person the educational success and the achievement of their maximum potential. If problem solving becomes a tool for the enhancement of talent in the classroom, training in this competence becomes essential. In the educational field, talent and excellence are based on a unique attitude or an accentuated interest that a person possesses. The topic of the ability to solve educational problems by those who are going to carry out the profession of teacher implies the a…