showing 36 of ~574560 from 574555 documents
Effects of Group Formation on Student Satisfaction and Performance: A Field Experiment
2021
This study analyzes the relation of group formation on outcomes of a 4-week online course for prospective students. Group formation was experimentally manipulated based on predefined criteria, personality traits conscientiousness and extraversion. As research questions, groups were considered advantageous if they were formed (a) heterogeneously in extraversion, and (b) homogeneously in conscientiousness. As a result, no uniform outcome was identified. Most variance could be explained on group level, but no significant main effect for experimental grouping was found. Significant interaction between both main effects hint that the results do not provide final answers, but guidance for furthe…
Lasten osallisuuden jännitteet varhaiskasvatuksessa
2021
Lasten osallisuus on varhaiskasvatuksessa pedagogisen toiminnan keskeinen tavoite. Osallisuuden toteutuminen voi olla kuitenkin käytännössä vaikeaa. Sitä hankaloittavat lasten osallisuuden epäselvä teoreettinen määrittely, tiedon puute osallisuutta tukevista käytännöistä ja toimintatavoista sekä varhaiskasvatuksen resursoinnin kysymykset. Varhaiskasvatuksen lapsiryhmät ovat yhä monimuotoisempia, ja myös siksi on tärkeää kehittää kasvattajien osaamista lasten osallisuuden huomioon ottamisessa. Jotta lasten osallisuus ja oikeudet osataan tunnistaa, on tunnettava niihin liittyvää tutkimustietoa ja lainsäädäntöä sekä uusia toimintatapoja. Artikkelissa tarkastelemme, millaista oli Oiva – Lasten …
Kohti sosioemotionaalisia taitoja ja lasten osallisuutta tukevaa toimintakulttuuria – ProVaka-toimintamallin pilottivaiheen analyysi
2021
Kaikkien lasten osallisuuden tukeminen edellyttää tarvittavan kehityksen ja oppimisen tuen järjestämistä varhaiskasvatukseen. Osallistavan varhaiskasvatuksen toimintakulttuurin kehittämisellä tuetaan koko lapsiryhmän kanssa toteutettavia toimintatapoja tukemaan kaikkien lasten käyttäytymistä ja sosioemotionaalisia taitoja. Käyttäytymispsykologinen Positiivisesti ryhmässä oppiva varhaiskasvatus (ProVaka) -toimintamalli edistää tutkimusnäyttöön pohjautuvien menetelmien käyttöönottoa sosiaalisen käyttäytymisen tukemisessa. ProVaka-toiminnassa korostuvat yhteisesti sovitut ja selkeät käyttäytymisodotukset, toivotun käyttäytymisen systemaattinen opettaminen ja käyttäytymiseen kohdennetulla posit…
Computational Science of Religion
2021
This article provides a basic overview of the most common methods of computer modelling and simulation that are currently being used to study religion. It focuses on the use (and illustrates the value) of system dynamics models, agent-based models, including game theory and multi-agent artificial intelligence models, and artificial neural networks. General use case examples are provided, and considerations for future research are discussed. We conclude by encouraging scholars interested in religion and related fields to incorporate techniques from the computational science of religion into their collaborative methodological toolkits.
Zinc(II) Complexes of Amino Acids as New Active Ingredients for Anti-Acne Dermatological Preparations.
2021
Zinc compounds have a number of beneficial properties for the skin, including antimicrobial, sebostatic and demulcent activities. The aim of the study was to develop new anti-acne preparations containing zinc–amino acid complexes as active ingredients. Firstly, the cytotoxicity of the zinc complexes was evaluated against human skin fibroblasts (1BR.3.N cell line) and human epidermal keratinocyte cell lines, and their antimicrobial activity was determined against Cutibacterium acnes. Then, zinc complexes of glycine and histidine were selected to create original gel formulations. The stability (by measuring pH, density and viscosity), microbiological purity (referring to PN-EN ISO standards) …
Searching for Physics Beyond the Standard Model in an Off-Axis DUNE Near Detector
2021
Next generation neutrino oscillation experiments like DUNE and T2HK are multi-purpose observatories, with a rich physics program beyond oscillation measurements. A special role is played by their near detector facilities, which are particularly well-suited to search for weakly coupled dark sector particles produced in the primary target. In this paper, we demonstrate this by estimating the sensitivity of the DUNE near detectors to the scattering of sub-GeV DM particles and to the decay of sub-GeV sterile neutrinos ("heavy neutral leptons"). We discuss in particular the importance of the DUNE-PRISM design, which allows some of the near detectors to be moved away from the beam axis. At such o…
Paediatric Sleep Questionnaire for Obstructive Sleep Apnoea Syndrome Screening: Is Sleep Quality Worthy of Note?
2021
Obstructive sleep apnoea syndrome (OSAS) is the most severe condition on the spectrum of sleep-related breathing disorders (SRBDs). The Paediatric Sleep Questionnaire (PSQ) is one of the most used and validated screening tools, but it lacks the comprehensive assessment of some determinants of OSAS, specifically anamnestic assessment and sleep quality. This study aims to assess the accuracy of some specific items added to the original PSQ, particularly related to the patient’s anamnestic history and to the quality of sleep, for the screening of OSAS in a paediatric population living in Sicily (Italy). Fifteen specific items, divided into “anamnestic” and “related to sleep quality” were added…
false
2021
Faster than expected Iodine species are one of only a handful of atmospheric vapors known to make new aerosol particles, which play a central role in controlling the radiative forcing of climate. He et al. report experimental evidence from the CERN Cosmics Leaving Outdoor Droplets, or CLOUD, chamber demonstrating that iodic acid and iodous acid rapidly form new particles and can compete with sulfuric acid in pristine regions. Science , this issue p. 589
Comparing oculomotor efficiency and visual attention between drivers and non-drivers through the Adult Developmental Eye Movement (ADEM) test: A visu…
2021
Objective The objective of this study was to assess and compare drivers’ and non-drivers’ outcomes in the Adult Developmental Eye Movement test (ADEM), a visual-verbal test that measures the time needed to read series of numbers in both a vertical and horizontal reading pattern. A set of driving parameters (i.e., experience, risk exposure, and day and night perceived difficulty) and demographic variables (i.e., age, gender, and academic level) were considered as potential predictors of the test performance. Methods For this cross-sectional study, 302 healthy subjects (age range 20 to 86 years old) completed a self-reported questionnaire aimed at retrieving data on the independent variables…
Selective CO 2 Sorption Using Compartmentalized Coordination Polymers with Discrete Voids**
2021
Carbon capture and storage with porous materials is one of the most promising technologies to minimize CO2 release into the atmosphere. Here, we report a family of compartmentalized coordination polymers (CCPs) capable of capturing gas molecules in a selective manner based on two novel tetrazole-based ligands. Crystal structures have been modelled theoretically under the Density Functional Theory (DFT) revealing the presence of discrete voids of 380 A3 . Single gas adsorption isotherms of N2 , CH4 and CO2 have been measured, obtaining a loading capacity of 0.6, 1.7 and 2.2 molecules/void at 10 bar and at 298 K for the best performing material. Moreover, they present excellent selectivity an…
Ring opening polymerization of ε-caprolactone initiated by titanium and vanadium complexes of ONO-type schiff base ligand
2021
AbstractA phenoxy-imine proligand with the additional OH donor group, 4,6-tBu2-2-(2-CH2(OH)-C6H4N = CH)C6H3OH (LH2), was synthesized and used to prepare group 4 and 5 complexes by reacting with Ti(OiPr)4 (LTi) and VO(OiPr)3 (LV). All new compounds were characterized by the FTIR, 1H and 13C NMR spectroscopy and LTi by the single-crystal X-ray diffraction analysis. The complexes were used as catalysts in the ring opening polymerization of ε-caprolactone. The influence of monomer/transition metal molar ratio, reaction time, polymerization temperature as well as complex type was investigated in detail. The complexes showed high (LTi) and moderate (LV) activity in ε-caprolactone polymerization a…
A review of venous thromboembolism in COVID‐19: A clinical perspective
2021
Abstract Coronavirus disease‐19 (COVID‐19) started in Wuhan, China in December 2019 and spread to all around the world in a short period of time. Hospitalized patients with COVID‐19 mostly could suffer from an abnormal coagulation activation risk with increased venous thrombosis events and a poor clinical course. The reported incidence rates of thrombotic complications in hospitalized COVID‐19 patients vary between 2.6 and 85% (both in non‐critically ill and critically ill patients). The risk of venous thromboembolism is not known in non‐hospitalized patients with COVID‐19. There are numerous studies and guidelines for administration of thromboprophylaxis for COVID‐19 cases. All hospitalize…
A Framework of Professional Transferable Competences for System Innovation: Enabling Leadership and Agency for Sustainable Development
2021
System Innovation (SI) is a critical approach in driving individual and collective actions towards sustainable development (SD). This article presents the validation process of the Climate-KIC Professional Competence Framework (CF) for SI. This framework is based on principles of system thinking and the need for human capital to deal with challenges related to long-term sustainability. It comprises twenty competences grouped into five stages that describe contexts where professionals implement transformations: Exploring, Framing, Designing, Implementing and Strengthening. The stages are not linear or strictly sequential because overlapping and loops are frequent in transformational and disr…
Chameleonic appearance of caseous calcification of the mitral valve – still a problem for its appropriate management
2021
According to the research literature, the caseous calcification of the mitral annulus (CCMA) is a rare variant of the mitral annulus calcification (MAC) entity, described mostly in elderly women. The aim of this study was to present the case of a 53-year-old female patient with caseous calcification of the mitral valve annulus and posterior cusp, which was diagnosed as papillary fibroelastoma. An echo-dense and quasi-homogeneous tumoral mass, measuring 1.6/1.4 cm, at the level of the posterior mitral ring was detected by echocardiographic examination, as well as by cardiac magnetic resonance imaging (MRI). Histopathological analysis revealed fibrous connective tissue with myxoid areas, hyal…
Speech Intelligibility Analysis and Approximation to Room Parameters through the Internet of Things
2021
In recent years, Wireless Acoustic Sensor Networks (WASN) have been widely applied to different acoustic fields in outdoor and indoor environments. Most of these applications are oriented to locate or identify sources and measure specific features of the environment involved. In this paper, we study the application of a WASN for room acoustic measurements. To evaluate the acoustic characteristics, a set of Raspberry Pi 3 (RPi) has been used. One is used to play different acoustic signals and four are used to record at different points in the room simultaneously. The signals are sent wirelessly to a computer connected to a server, where using MATLAB we calculate both the impulse response (IR…
Role of precursor composition in the polymorph transformations, morphology control and ferromagnetic properties of nanosized TiO$_2$
2021
Pure phase and mixed phase TiO$_2$ nanoparticles have been produced using a pyrolytic method from a non-aqueous carboxylate precursor. The precursor was prepared by a multiphase cation exchange using pentanoic acid (C$_4$H$_9$COOH). The thermal stability, polymorph content, morphology, size distribution and surface region of the produced nanoparticles were studied by TGA/DSC, XRD, FTIR and TEM. High quality monodisperse nanoparticles have been produced in the size range from 7 to 27 nm. The nanoparticles showed room temperature ferromagnetism revealed by VSM within bound polaron model. The carboxylate precursor is a good alternative to standard sol-gel to produce nanoparticles free from imp…
false
2021
Purpose First, this experimental study aims at comparing out-of-field doses delivered by three radiotherapy techniques (3DCRT, VMAT (two different accelerators), and tomotherapy) for a pediatric renal treatment. Secondly, the accuracy of treatment planning systems (TPS) for out-of-field calculation is evaluated. Methods EBT3 films were positioned in pediatric phantoms (5 and 10 yr old). They were irradiated according to four plans: 3DCRT (Clinac 2100CS, Varian), VMAT (Clinac 2100CS and Halcyon, Varian), and tomotherapy for a same target volume. 3D dose determination was performed with an in-house Matlab tool using linear interpolation of film measurements. 1D and 3D comparisons were made be…
A group invariant Bishop-Phelps theorem
2021
We show that for any Banach space and any compact topological group G ⊂ L ( X ) G\subset L(X) such that the norm of X X is G G -invariant, the set of norm attaining G G -invariant functionals on X X is dense in the set of all G G -invariant functionals on X X , where a mapping f f is called G G -invariant if for every x ∈ X x\in X and every g ∈ G g\in G , f ( g ( x ) ) = f ( x ) f\big (g(x)\big )=f(x) . In contrast, we show also that the analog of Bollobás result does not hold in general. A version of Bollobás and James’ theorems is also presented.
Patient Preferences for Lung Cancer Treatment: A Qualitative Study Protocol Among Advanced Lung Cancer Patients
2021
Introduction: Lung cancer is the deadliest and most prevalent cancer worldwide. Lung cancer treatments have different characteristics and are associated with a range of benefits and side effects for patients. Such differences may raise uncertainty among drug developers, regulators, payers, and clinicians regarding the value of these treatment effects to patients. The value of conducting patient preference studies (using qualitative and/or quantitative methods) for benefits and side effects of different treatment options has been recognized by healthcare stakeholders, such as drug developers, regulators, health technology assessment bodies, and clinicians. However, evidence-based guidelines …
Spanish Scientists' Opinion about Science and Researcher Behavior.
2021
Encuestamos a 348 investigadores de Psicología y Educación en España, sobre temas como su percepción de una crisis en la ciencia, su confianza en la calidad de los resultados publicados y el uso de prácticas de investigación cuestionables (QRP). También se recogieron sus percepciones respecto a la presión por publicar y la competencia académica. Los resultados indican que una gran parte de la muestra de académicos españoles piensa que existe una crisis en la Ciencia, principalmente por falta de inversión económica, y duda de la calidad de los hallazgos publicados. También sienten una fuerte presión para publicar en revistas de alto factor de impacto y un clima laboral altamente competitivo.…
Polarization and Spectacle in the Spanish Political Talk Show ‘La Sexta Noche’ During the 2019 European Elections
2021
This article analyses how in the main political talk show on television in Spain, La Sexta Noche, the main themes of the European agenda were silenced or conditioned by the themes of the national, regional and local agenda during the last European elec-tions. The media debate was oriented towards an analysis of the results of national elections and the campaign for regional and local elections that al-lowed for a greater spectacle, thanks to the shock effect of such polarized ideol-ogies and the trivialization of national politics. This research has studied all the shows of the programme broad-cast as of the national elections on 28th April 2019 up until the European elections held on 26th …
Labyrinthe de labyrinthes : l'art de l'enquête comme poursuite de l'oeuvre perecquienne dans l'Ouvroir de Littérature Potentielle
2021
International audience; La publication de « 53 jours » aux éditions P.O.L. en 1989 n'est pas seulement celle d'un roman de Georges Perec. L'oeuvre sur laquelle travaillait l'oulipien au moment de sa mort est inachevée et l'édition du texte est établie par deux autres membres de l'Ouvroir de Littérature Potentielle : Jacques Roubaud et Harry Mathews qui font figurer non seulement le texte rédigé par Perec mais aussi un dossier de brouillons et de notes. Nous proposons donc d'appréhender « 53 jours » non comme une fiction romanesque de Georges Perec mais comme la représentation d'un fragment d'oeuvre en attente perpétuelle d'achèvement. Et cela non seulement par les deux membres de l'OuLiPo q…
Reply to: Safety and efficacy of secukinumab treatment in a patient with ankylosing spondylitis and concomitant multiple sclerosis: A commentary
2021
No abstract available
Energetic analysis of succinic acid in water droplets: insight into the size-dependent solubility of atmospheric nanoparticles
2021
<p>Size-dependent solubility is prevalent in atmospheric nanoparticles, but a molecular level understanding is still insufficient, especially for organic compounds. Here, we performed molecular dynamics simulations to investigate the size dependence of succinic acid solvation on the scale of ~1-4 nm with the potential of mean forces method. Our analyses reveal that the surface preference of succinic acid is stronger for a droplet than the slab of the same size, and the surface propensity is enhanced due to the curvature effect as the droplet becomes smaller. Energetic analyses show that such surface preference is primarily an enthalpic effect in both systems, while the entropi…
Mutation-specific pathophysiological mechanisms define different neurodevelopmental disorders associated with SATB1 dysfunction
2021
AbstractWhereas large-scale statistical analyses can robustly identify disease-gene relationships, they do not accurately capture genotype-phenotype correlations or disease mechanisms. We use multiple lines of independent evidence to show that different variant types in a single gene,SATB1, cause clinically overlapping but distinct neurodevelopmental disorders. Clinical evaluation of 42 individuals carryingSATB1variants identified overt genotype-phenotype relationships, associated with different pathophysiological mechanisms, established by functional assays. Missense variants in the CUT1 and CUT2 DNA-binding domains result in stronger chromatin binding, increased transcriptional repression…
A muramidase from Acremonium alcalophilum hydrolyse peptidoglycan found in the gastrointestinal tract of broiler chickens
2021
Abstract This study evaluates peptidoglycan hydrolysis by a microbial muramidase from the fungus Acremonium alcalophilum in vitro and in the gastrointestinal tract of broiler chickens. Peptidoglycan used for in vitro studies was derived from 5 gram-positive chicken gut isolate type strains. In vitro peptidoglycan hydrolysis was studied by three approaches: (a) helium ion microscopy to identify visual phenotypes of hydrolysis, (b) reducing end assay to quantify solubilization of peptidoglycan fragments, and (c) mass spectroscopy to estimate relative abundances of soluble substrates and reaction products. Visual effects of peptidoglycan hydrolysis could be observed by helium ion microscopy an…
Trends in hospitalization of patients with diabetes mellitus in Ghana from 2012 to 2017 with predictions to 2032
2021
Abstract Background This study explores sociodemographic and health factors associated with hospitalizing diabetes mellitus (DM) patients and estimates the number of future hospitalizations for DM in Ghana. Methods We conducted a secondary analysis using nationally representative patient hospitalization data provided by the Ghana Health Service and projected population counts from the Ghana Statistical Service. Data were stratified by year, age, sex and region. We employed Poisson regression to determine associations between sociodemographic and health factors and hospitalization rates of DM patients. Using projected population counts, the number of DM-related hospitalizations for 2018 thro…
Soluble/MOF-Supported Palladium Single Atoms Catalyze the Ligand-, Additive-, and Solvent-Free Aerobic Oxidation of Benzyl Alcohols to Benzoic Acids.
2021
Metal single-atom catalysts (SACs) promise great rewards in terms of metal atom efficiency. However, the requirement of particular conditions and supports for their synthesis, together with the need of solvents and additives for catalytic implementation, often precludes their use under industrially viable conditions. Here, we show that palladium single atoms are spontaneously formed after dissolving tiny amounts of palladium salts in neat benzyl alcohols, to catalyze their direct aerobic oxidation to benzoic acids without ligands, additives, or solvents. With this result in hand, the gram-scale preparation and stabilization of Pd SACs within the functional channels of a novel methyl-cystein…
Current Predictive Resting Metabolic Rate Equations Are Not Sufficient to Determine Proper Resting Energy Expenditure in Olympic Young Adult National…
2021
Predictive resting metabolic rate (RMR) equations are widely used to determine athletes’ resting energy expenditure (REE). However, it remains unclear whether these predictive RMR equations accurately predict REE in the athletic populations. The purpose of the study was to compare 12 prediction equations (Harris-Benedict, Mifflin, Schofield, Cunningham, Owen, Liu’s, De Lorenzo) with measured RMR in Turkish national team athletes and sedentary controls. A total of 97 participants, 49 athletes (24 females, 25 males), and 48 sedentary (28 females, 20 males), were recruited from Turkey National Olympic Teams at the Ministry of Youth and Sports. RMR was measured using a Fitmate GS (Cosmed, Italy…
The Case for Regulating Huawei
2021
Huawei’s growth overseas has paralleled that of China Inc ( Li and Farrell, 2020 ). Through favorable policies such as the Belt and Road Initiative, China has paved the way for Chinese multinationals to capture global markets, acquire and exploit new technologies, and have privileged access to local resources. In turn, Huawei has played an important role in the development of China Inc., its technological capabilities and global diplomatic relations. But Huawei plays by a different set of rules: it has been accused of unfair and illegal practices, and for breaking international norms. This perspective explores the need for regulatory oversight of Huawei.
Evidence for metastable photo-induced superconductivity in K3C60
2021
Far and mid infrared optical pulses have been shown to induce non-equilibrium unconventional orders in complex materials, including photo-induced ferroelectricity in quantum paraelectrics, magnetic polarization in antiferromagnets and transient superconducting correlations in the normal state of cuprates and organic conductors. In the case of non-equilibrium superconductivity, femtosecond drives have generally resulted in electronic properties that disappear immediately after excitation, evidencing a state that lacks intrinsic rigidity. Here, we make use of a new optical device to drive metallic K$_3$C$_{60}$ with mid-infrared pulses of tunable duration, ranging between one picosecond and o…
KEYNOTE-975 study design: a Phase III study of definitive chemoradiotherapy plus pembrolizumab in patients with esophageal carcinoma
2021
Despite curative-intent treatment, most patients with locally advanced esophageal cancer will experience disease recurrence or locoregional progression, highlighting the need for new therapies. Current guidelines recommend definitive chemoradiotherapy in patients ineligible for surgical resection, but survival outcomes are poor. Pembrolizumab is well tolerated and provides promising antitumor activity in patients with previously treated, advanced, unresectable esophageal/esophagogastric junction cancer. Combining pembrolizumab with chemoradiotherapy may further improve outcomes in the first-line setting. Here, we describe the design and rationale for the double-blind, Phase III, placebo-co…
Effect of Core-Crosslinking on Protein Corona Formation on Polymeric Micelles.
2021
Most nanomaterials acquire a protein corona upon contact with biological fluids. The magnitude of this effect is strongly dependent both on surface and structure of the nanoparticle. To define the contribution of the internal nanoparticle structure, protein corona formation of block copolymer micelles with poly(N-2-hydroxypropylmethacrylamide) (pHPMA) as hydrophilic shell, which are crosslinked-or not-in the hydrophobic core is comparatively analyzed. Both types of micelles are incubated with human blood plasma and separated by asymmetrical flow field-flow fractionation (AF4). Their size is determined by dynamic light scattering and proteins within the micellar fraction are characterized by…
Analysis of rill step–pool morphology and its comparison with stream case
2021
In this paper, the morphology of step–pool features is analysed using rill measurements and literature data for streams. Close-range photogrammetry was used to carry out ground measurements on rills with step–pool units, shaped on a plot having slope equal to 14, 15, 22, 24 and 26%. Data were used to compare the relationships between H/L, in which H is the step height and L is the step length, and the mean gradient of the step–pool sequence, Sm, for streams or the slope of the step–pool unit, S, for rills. The relationship of H/L against Sm is widely used to test the occurrence of the maximum flow resistance condition in streams, which is associated with the range 1 ≤ (H/L)/Sm ≤ 2. Further …
Exfoliation of Alpha-Germanium: A Covalent Diamond-Like Structure
2021
2D materials have opened a new field in materials science with outstanding scientific and technological impact. A largely explored route for the preparation of 2D materials is the exfoliation of layered crystals with weak forces between their layers. However, its application to covalent crystals remains elusive. Herein, a further step is taken by introducing the exfoliation of germanium, a narrow-bandgap semiconductor presenting a 3D diamond-like structure with strong covalent bonds. Pure α-germanium is exfoliated following a simple one-step procedure assisted by wet ball-milling, allowing gram-scale fabrication of high-quality layers with large lateral dimensions and nanometer thicknesses.…