showing 36 of ~574560 from 574555 documents
The contribution of geographical certification programs to farm income and rural economies: The case of Pecorino Siciliano PDO
2021
This study attempts to measure the capacity of the EU geographical certification scheme to positively influence the price of certified products and the incomes of their producers. A comparison of the economic results of two cheese-producing dairy farm enterprises with different business strategies and locations within the Sicilian hinterlands is performed in order to determine the transformation value of each dairy’s sheep milk into pecorino cheese (with and without the Protected Designation of Origin, or PDO, certification) and the related joint products (ricotta). The economic convenience of the total transformation of sheep milk into Pecorino Siciliano PDO and ricotta is also appraised. …
The cyto-protective effects of LH on ovarian reserve and female fertility during exposure to gonadotoxic alkylating agents in an adult mouse model.
2021
Abstract STUDY QUESTION Does LH protect mouse oocytes and female fertility from alkylating chemotherapy? SUMMARY ANSWER LH treatment before and during chemotherapy prevents detrimental effects on follicles and reproductive lifespan. WHAT IS KNOWN ALREADY Chemotherapies can damage the ovary, resulting in premature ovarian failure and reduced fertility in cancer survivors. LH was recently suggested to protect prepubertal mouse follicles from chemotoxic effects of cisplatin treatment. STUDY DESIGN, SIZE, DURATION This experimental study investigated LH effects on primordial follicles exposed to chemotherapy. Seven-week-old CD-1 female mice were randomly allocated to four experimental groups: C…
Oral complaints in patients with acute myeloid leukemia treated with allogeneic hematopoietic stem cell transplantation
2021
Background Acute myeloid leukemia belongs to proliferative diseases of the hematopoietic system. It is currently the leading indication for allogeneic hematopoietic stem cell transplantation. This study was designed to determine the most common subjective oral mucosa complaints in patients with acute myeloid leukemia after allogeneic hematopoietic cell transplantation, in relation to the type of conditioning used. Material and Methods Eighty patients diagnosed with acute myeloid leukemia were assigned to two groups depending on the intensity of the conditioning regimen before transplantation: myeloablative and reduced-intensity chemotherapy. The oral symptoms were evaluated based on an auth…
La Carta Social Europea y los derechos sociales emergentes: una aproximación al derecho de acceso a la información ambiental
2021
La protección de los derechos sociales constituye, hoy en día, un fin primordial, y en Europa, la Carta Social Europea Revisada juega un papel relevante como guardiana del modelo del Estado social, como verdadera Constitución Social de Europa y como el estándar de protección más elevado de los derechos sociales, en general, y de los derechos sociales emergentes, en particular. Así, resulta de especial interés estudiar el derecho de acceso a la información ambiental como derecho social emergente derivado, en gran parte, del genérico derecho a un medio ambiente sano. Este derecho se puede definir, en términos muy simples, como el derecho del público en general a recibir información relacionad…
Fostering sustainable community outcomes through policy networks: a dynamic performance governance approach
2021
This chapter will illustrate how an “outside-in” view of policy making may implement a balanced perspective for assessing sustainable outcomes through an integrated Dynamic Performance Management and Governance framework. In the next sections such a framework will be illustrated and applied to different examples of collaborative networks. In the remaining part of this section practical implications from an “outside-in” view of policy making will be illustrated.
El delito de desaparición de personas, su aplicación y diferencias con otros tipos penales
2021
El tipo penal de desaparición de personas regulado en el ordenamiento jurídico mexicano, comparte elementos constitutivos con otros tipos penales, como el secuestro o la privación ilegal de la libertad. De ahí la importancia de construir y aplicar criterios para encuadrar debidamente el hecho delictivo en la figura penal que mejor lo comprenda.
Online Grocery Shopping at Multichannel Supermarkets: The Impact of Retailer Brand Equity
2021
Online shopping for food products is quickly accelerating worldwide, particularly following the impact of COVID-19 pandemic. Most e-grocers are multichannel supermarkets that have developed the onl...
Application of Fermentation to Recover High‐Added Value Compounds from Food By‐Products
2021
Kondo, Dorinne. Worldmaking: race, performance, and the work of creativity. xiv, 359 pp., illus., bibliogr. Durham, N.C.: Duke Univ. Press, 2018. £21…
2021
Analysis of cold activation of the contact system in hereditary angioedema with normal C1 inhibitor.
2021
Hereditary angioedema (HAE) attacks are caused by excessive activation of the contact system. Understanding how the contact system is activated in HAE, especially in patients with normal C1 inhibitor (HAEnCI), is essential to effectively treat this disease. Contact system activation involves the cleavage of several proteins including Factor XII (FXII), high molecular weight kininogen (HK), prekallikrein, sgp120 (ITIH4) and C1 inhibitor (C1-INH) before the subsequent generation of bradykinin that mediates HAE. In this study, we evaluated the fragmentation and enzymatic activity of contact system proteins in HAEnCI plasma samples before and after contact system activation induced by incubatio…
Kinetics and Topology of DNA Associated with Circulating Extracellular Vesicles Released during Exercise.
2021
AbstractAlthough it is widely accepted that cancer derived extracellular vesicles (EVs) carry DNA cargo, the association of cell-free circulating DNA (cfDNA) and EVs in plasma of healthy humans remains elusive. Using a physiological exercise model, where EVs and cfDNA are synchronously released, we aimed to characterize the kinetics and localization of DNA associated with EVs. EVs were separated from human plasma using size exclusion chromatography or immuno-affinity capture for CD9+, CD63+, and CD81+ EVs. DNA was quantified with an ultra-sensitive qPCR assay targeting repetitive LINE elements, with or without DNase digestion. This model shows that a minute part of circulating cell-free DNA…
An investigation of the potential association between gastrointestinal viral and bacterial infection and development of intestinal acute graft versus…
2021
It is uncertain whether gastrointestinal (GI) infection caused by viral and bacterial pathogens may predispose to gastrointestinal acute Graft-versus-host disease (aGvHD-GI) in allogeneic hematopoietic stem cell transplant recipients (allo-HSCT). We investigated the potential association between detection of enteropathogenic viruses or bacteria in stools and subsequent occurrence of aGvHD-GI in a cohort of 121 allo-HSCT patients. Eighty-six out of 121 patients (71%) had acute diarrhea and underwent screening for primary GI pathogens by molecular diagnostic methods. One or more GI pathogens were detected in 27 out of the 86 patients with diarrhea (31.3%). Specifically, Clostridioides diffici…
Efficacy and one-year outcomes of Luminor® paclitaxel-coated drug-eluting balloon in the treatment of popliteal artery atherosclerosis lesions
2021
Purpose: Reporting outcomes with a new generation paclitaxel eluting balloon (Luminor®; iVascular, Vascular, S.L.U., Barcelona, Spain) in the popliteal district. Endovascular treatment of popliteal artery atherosclerotic disease is still debated without definitive evidences. Methods: From January to June 2019, patients’ data presenting popliteal artery atherosclerotic diseases and treated with the Luminor® (iVascular) drug eluting balloon (DEB) were prospectively collected. Critical limb ischemia (CLI) or severe claudication associated with popliteal artery stenosis >50% were the inclusion criteria. Measured outcomes were technical success, early and late results; including mortality, mo…
Improving the Robustness of Organic Semiconductors through Hydrogen Bonding
2021
Molecular organization plays an essential role in organic semiconductors since it determines the extent of intermolecular interactions that govern the charge transport present in all electronic applications. The benefits of hydrogen bond-directed self-assembly on charge transport properties are demonstrated by comparing two analogous pyrrole-based, fused heptacyclic molecules. The rationally designed synthesis of these materials allows for inducing or preventing hydrogen bonding. Strategically located hydrogen bond donor and acceptor sites control the solid-state arrangement, favoring the supramolecular expansion of the π-conjugated surface and the subsequent π-stacking as proved by X-ray d…
Ķīmijas sekcija: tēžu krājums
2021
El género Parabailiella Thoral, 1946 (Trilobita) en el Cámbrico Medio de las cadenas ibéricas (NE de España)
2021
Se analiza el registro del género Parabailiella Thoral, 1946 en el Cámbrico medio de las Cadenas Ibéricas, al tiempo que se identifican y describen por primera vez en la región las cuatro especies que previamente se habían incluido en este género. La mayoría de las especies se encuentran registradas en varias secciones y las cuatro se han identificado en la sección Jarque 1. La distribución bioestratigráfica del género abarca desde el Leoniense medio hasta la base del Caesaraugustiense superior, lo que equivale en la escala propuesta por la International Subcommission on Cambrian Stratigraphy (ISCS) a la mayor parte del Piso 5 del Cámbrico y a la parte inferior del Piso Drumiense. La distri…
Effects of Modified Atmosphere Packaging and Chitosan Treatment on Quality and Sensorial Parameters of Minimally Processed cv. ‘Italia’ Table Grapes
2021
Table grape is a non-climacteric fruit, very sensitive to water loss and gray mold during postharvest handling and storage. The aim of this work was to evaluate the effects of modified atmosphere packaging and chitosan treatment on quality and sensorial parameters of minimally processed cv. ‘Italia’ table grape during cold storage (14 days at 5 °C) and shelf-life (7 and 14 days of cold storage plus 5 days at 20 °C), reproducing a retail sales condition. Our data showed a significant effect of high CO2-modified atmosphere in combination with chitosan and alone on preserving quality, sensorial parameters, and delaying decay of minimally processed table grape. The most effective treatment in t…
Biomass Fractionation Using Emerging Technologies
2021
Deep learning for diagnosis and survival prediction in soft tissue sarcoma.
2021
Background Clinical management of soft tissue sarcoma (STS) is particularly challenging. Here, we used digital pathology and deep learning (DL) for diagnosis and prognosis prediction of STS. Patients and methods Our retrospective, multicenter study included a total of 506 histopathological slides from 291 patients with STS. The Cancer Genome Atlas cohort (240 patients) served as training and validation set. A second, multicenter cohort (51 patients) served as an additional test set. The use of the DL model (DLM) as a clinical decision support system was evaluated by nine pathologists with different levels of expertise. For prognosis prediction, 139 slides from 85 patients with leiomyosarcom…
Impact of frailty and atrial fibrillation in elderly patients with acute coronary syndromes
2021
Background: There is scarce information on the prognostic role of frailty and Atrial Fibrillation (AF) in elderly patients Acute Coronary Syndrome (ACS). Methods: The aim was to analyse the management of elderly patients with frailty and AF who suffered an ACS using data of the prospective multicentre LONGEVO-SCA registry. We evaluated the predictive performance of FRAIL, Charlson scores and AF status for adverse events at 6 months follow-up. Results: A total of 531 unselected patients with ACS and above 80 years old [mean age 84.4 (SD=3.6) years; 322 (60.6%) male] were enrolled, of whom 128 (24.1%) with AF and 145 (27.3%) with frailty. Mutually exclusive number of patients were as follows:…
Leading-order QED radiative corrections to timelike Compton scattering on the proton
2021
We evaluate the leading-order QED radiative corrections to the timelike Compton scattering (TCS) process $\gamma p \to l^- l^+ p$. We study these corrections in two energy regimes using different models for the TCS amplitude. In the low-energy regime we calculate the contribution due to the proton and its lowest-energy excitation, the $\Delta(1232)$ resonance. In the high-energy near-forward kinematical regime we calculate the TCS amplitude in a handbag approach in terms of Generalized Parton Distributions (GPDs). On the level of cross sections we find the QED radiative corrections to be in the $5 -10\%$ range in the low-energy regime and around $20\%$ in the high-energy regime. We show tha…
Software startup education: gamifying growth hacking
2021
Startups seek to create highly scalable business models. For startups, growth is thus vital. Growth hacking is a marketing strategy advocated by various startup practitioner experts. It focuses on using low cost practices while utilizing existing platforms in creative ways to gain more users for the service. Though topics related to growth hacking such as marketing on a general level have been extensively studied in the past, growth hacking as a practitioner-born topic has not seen much interest among the academia. To both spark interest in growth hacking, and to facilitate teaching growth hacking in the academia, we present two board games intended to serve as an engaging introduction to g…
Effect of application time and concentration of silver diamine fluoride on the enamel remineralization
2021
Background Silver diamine fluoride has attracted attention because of its clinical success in arresting dental caries. Thus, the aim of this study was to evaluate the effect of different application times and concentrations of silver diamine fluoride (SDF) on deciduous tooth enamel remineralization. Material and Methods Blocks of deciduous tooth enamel were categorized into six groups of 11 each: 2 control groups: intact enamel, and demineralized enamel; 38% SDF and 30% SDF which were subdivided according to application times (1 and 3 min). The microhardness of samples was determined, and all groups except the intact enamel group were subjected to pH cycling to produce initial carious lesio…
Singulett‐Kontrast‐Magnetresonanztomographie: Freisetzung der Hyperpolarisation durch den Metabolismus**
2021
The Causal Influence of Life Meaning on Weight and Shape Concerns in Women at Risk for Developing an Eating Disorder
2021
Background: Although previous studies have shown an inverse relation between life meaning and eating disorder symptoms, the correlational nature of this evidence precludes causal inferences. Therefore, this study used an experimental approach to test the causal impact of life meaning on individuals' weight and shape concerns.Methods: Female students at risk for developing an eating disorder (N = 128) were randomly assigned to the control or the meaning condition, which involved thinking about and committing to pursue intrinsically valued life goals. A color-naming interference task was used to assess the motivational salience of body-related stimuli, and self-report measures were used to as…
Surgical anatomy applied to the international classification of the abdominal wall planes (ICAP) - a video vignette.
2021
Date-rape evidence through fast determination of γ-butyrolactone in adulterated beverages.
2021
Abstract An infrared spectroscopy (IR) based methodology has been developed to determine γ-butyrolactone (GBL) in adulterated beverages. The proposed method permits the direct screening of GBL in beverages and involves a minimum sample treatment requiring less than 2 min for quantitative determination of GBL. Sensitivity of IR method was improved by using liquid-liquid extraction (LLE) providing detection limits of 0.023 mg g−1. Accuracy of the proposed methodology was evaluated through the analysis of soft beverages and alcoholic cocktails spiked with GBL at concentration levels ranging from 0.075 to 10 mg g−1 providing recovery values from 91 to 100%. GBL was determined in twelve blind-sp…
Integrative review of Islamic marketing
2021
Purpose The purpose of this study is to integrate and synthesize the Islamic marketing literature, understand the phenomenon and related concepts and provide suggestions for future research. Design/methodology/approach The study uses an integrative review method that emphasizes summarizing and synthesizing the previous literature related to a phenomenon. Findings The findings indicate the emergence of five major themes, namely, Islamic marketing and its perspectives, activities in Islamic marketing, opportunities, controversies and challenges in Islamic marketing, Islamic principles and determinants of consumers’ behavior and awareness toward Islamic products. Each of the major themes cons…
Adverse events following immunization and vaccine perception in nursing students.
2021
Introduction. Vaccines are one of the most successful and cost-effective public health interventions of modern times. This cross-sectional study investigated the perception of vaccinations and potential risks of adverse events following immunization among nursing students. Materials and Methods. An anonymous, self-administered questionnaire was distributed to students undertaking a nursing degree course at the University of Palermo. This questionnaire consisted of three sections: the first part focused on socio-demographic information; the second part contained one question regarding the terms associated with vaccination; and the third part posed a question regarding adverse reactions after…
Meta-analysis of the correlation between serum uric acid level and carotid intima-media thickness
2021
Objective Recently, increasing epidemiological evidence has shown that there is a correlation between serum uric acid level (SUA) and carotid intima-media thickness (CIMT). This paper explored the relationship between them through meta-analysis. Methods PubMed, Cochrane Library, EMBASE, Web of Science and Google Scholar were searched to obtain literature. The keywords used to retrieve the literature were carotid intima thickness, intima-media thickness, carotid atherosclerosis, carotid stenosis, carotid artery, uric acid, blood uric acid, and hyperuricaemia. The retrieval time was from the establishment of the database through July 2020. Stata15.0 and RevMan5.3 software were used for stati…
Electronic structure of the ytterbium monohydroxide molecule to search for axionlike particles
2021
Recently, the YbOH molecule has been suggested as a candidate to search for the electron electric dipole moment (eEDM), which violates spatial parity ($P$) and time-reversal ($T$) symmetries [I. Kozyryev and N. R. Hutzler, Phys. Rev. Lett. 119, 133002 (2017)]. In the present paper, we show that the same system can be used to measure coupling constants of the interaction of electrons and nucleus mediated by axionlike particles. The electron-nucleus interaction produced by the axion exchange can contribute to a $T,P$-violating EDM of the whole molecular system. We express the corresponding $T,P$-violating energy shift produced by this effect in terms of the axion mass and product of the axion…
Computing Metal-Binding Proteins for Therapeutic Benefit
2021
Over one third of biomolecules rely on metal ions to exert their cellular functions. Metal ions can play a structural role by stabilizing the structure of biomolecules, a functional role by promoting a wide variety of biochemical reactions, and a regulatory role by acting as messengers upon binding to proteins regulating cellular metal-homeostasis. These diverse roles in biology ascribe critical implications to metal-binding proteins in the onset of many diseases. Hence, it is of utmost importance to exhaustively unlock the different mechanistic facets of metal-binding proteins and to harness this knowledge to rationally devise novel therapeutic strategies to prevent or cure pathological st…
Lipoedema – a growing problem in Spain
2021
AbstractLipoedema is a chronic disease frequent in women, that causes an abnormal fat deposition in their lower limbs, with a remarkable disproportion between the upper and lower part of the body, easy bruising and pain. Despite the lack of pathognomonic tests for lipoedema, more and more patients in social networks are claiming they suffer from it, giving the disease more visibility but allowing a lot of fake information about lipoedema. Information for self-care and realistic expectations are important. Depending on the severity, the treatment includes: physical therapies, compression garments, exercise, diet, psychological support and surgical treatment.
N‑Oxide Polyethers as Kinetic Hydrate Inhibitors: Side Chain Ring Size Makes the Difference
2021
The formation of gas hydrates in flow lines is one of the most severe problems for flow assurance in the gas and oil industry. Developing effective kinetic hydrate inhibitors (KHIs) to avoid the problem of gas hydrate formation has attracted widespread attention. In this study, a series of poly(glycidyl amine N-oxide)s (PGAOs) with 5–7-membered rings as side chains, poly(pyrrolidine glycidyl amine N-oxide)s (PPyrGAOs), poly(piperidine glycidyl amine N-oxide)s (PPiGAOs), and poly(azepane glycidyl amine N-oxide)s (PAzGAOs), with varying molecular weights, have been synthesized. The KHI performance of these glycidyl amine N-oxide polyethers has been evaluated in high-pressure rocking cells wit…
Gogol entre le baroque et l’expressionisme : la ligne « gogolienne » dans le formalisme européen
2021
International audience
Assessment of the Pressure Level over Lentic Waterbodies through the Estimation of Land Uses in the Catchment and Hydro-Morphological Alterations: Th…
2021
The features of lentic waterbodies largely depend on the surrounding environment. Mediterranean coastal lagoons have been historically altered, with their catchment being highly modified for agricultural, livestock, or urban uses. Changes in land uses induce pressures that impact the waterbodies and alter their ecological status. The objectives of this paper were: to develop a methodological approach (LUPLES: Land Uses for estimating Pressure Levels to approach the Ecological Status), to quantify the main pressures on the waterbodies and to forecast the possible impacts of these pressures on their ecological status. Corine-Land Cover maps and Geographic Information System technics were used…