Multicentre Study of Chronic Wounds Point Prevalence in Primary Health Care in the Southern Metropolitan Area of Barcelona

2021

Background: Chronic wounds give rise to major costs and resource consumption in health care systems, due to their protracted healing time. Incidence and prevalence data are scarce or nonexistent in community settings. Objective: The aim of the present epidemiological study was to analyse and determine the prevalence of chronic wounds in the community in the south of the province of Barcelona (Spain). Design: A cross-sectional, multicentre secondary data analysis study was conducted in the community (excluding nursing homes) in Barcelona between 16 April and 13 June 2013. It included 52 primary care centres that serve a total population of 1,217,564 inhabitants. Results: The observed prevale…

A shifting yet grounded transnational social field: Interplays of displacement and emplacement in African migrant trajectories across Central America

2021

In this article, we draw on the volatile complexity of African migrant trajectories in Central America to broaden the scope of transnational scholarship. These trajectories are characterised by mobilities as well as immobilities, taking shape in particular local contexts. By focusing on the interplays between displacement and emplacement that are part of these trajectories, we aim to increase our understanding of the extent to which migrants still ‘on the move’ experience both temporal embeddedness and cross-border connectedness, thereby acknowledging and unravelling transnational lives as they ‘touch the ground’ en route. To do so, we build on long-standing scholarly commitments in Central…

Violence against women in heterosexual couples: A review of psychological and medico-legal considerations.

2021

Intimate partner violence against women (IPVAW) is the most pervasive violation of women’s rights worldwide, causing devastating lifelong damage. Victims can suffer physical, emotional or mental health problems, and experience detrimental effects in social, psychological and relational health with their families, especially children. Due to the complexity regarding violence against women in heterosexual couples, it is important to make a clear distinction between psychological and physical mistreatment, which also includes psychological violence. This differentiation is important in determining different emotional and psychological aspects of mistreatment in order to understand the reasons …

Teacher-child interaction quality and children's self-regulation in toddler classrooms in Finland and Portugal

2021

This study examines the association between teacher–child interaction quality and children's self‐regulation in Finnish and Portuguese toddler classrooms. The participants included 230 Finnish (M = 29; SD = 3 months) and 283 Portuguese (M = 30, SD = 4 months) toddlers and their teachers (n = 43 Finland; n = 29 Portugal). The children's behavioural self‐regulation (attention, working memory, and inhibition control) was individually tested, and the teachers evaluated the children's self‐regulation skills in the classroom. The quality of the teacher–child interactions (i.e., emotional and behavioural support and engaged support for learning) was evaluated using the CLASS‐Toddler observation in…

Durability of Advanced Polymer Composites: Book of abstracts

2021

Mutations in PRDM15 Are a Novel Cause of Galloway-Mowat Syndrome

2021

Background Galloway-Mowat syndrome (GAMOS) is characterized by neurodevelopmental defects and a progressive nephropathy, which typically manifests as steroid-resistant nephrotic syndrome. The prognosis of GAMOS is poor, and the majority of children progress to renal failure. The discovery of monogenic causes of GAMOS has uncovered molecular pathways involved in the pathogenesis of disease. Methods Homozygosity mapping, whole-exome sequencing, and linkage analysis were used to identify mutations in four families with a GAMOS-like phenotype, and high-throughput PCR technology was applied to 91 individuals with GAMOS and 816 individuals with isolated nephrotic syndrome. In vitro and in vivo st…

N order solutions with multi-parameters to the Boussinesq and KP equations and the degenerate rational case

2021

From elementary exponential functions which depend on several parameters, we construct multi-parametric solutions to the Boussinesq equation. When we perform a passage to the limit when one of these parameters goes to 0, we get rational solutions as a quotient of a polynomial of degree N (N + 1) − 2 in x and t, by a polynomial of degree N (N + 1) in x and t for each positive integer N depending on 3N parameters. We restrict ourself to give the explicit expressions of these rational solutions for N = 1 until N = 3 to shortened the paper. We easily deduce the corresponding explicit rational solutions to the Kadomtsev Petviashvili equation for the same orders from 1 to 3.

Dataset related to article "Patients with Inflammatory Bowel Disease Are Not at Increased Risk of COVID-19: A Large Multinational Cohort Study"

2021

This record contains raw data related to article “Patients with Inflammatory Bowel Disease Are Not at Increased Risk of COVID-19: A Large Multinational Cohort Study" The impact of COVID-19 on inflammatory bowel disease (IBD) patients under pharmacological immunosuppression is still not clearly understood. We investigated the incidence of COVID-19 and the impact of immunosuppression and containment measures on the risk of SARS-CoV-2 infection in a large IBD cohort, from a multicenter cohort from 21st of February to 30th of June, 2020. Ninety-seven patients with IBD (43 UC, 53 CD, one unclassified IBD) and concomitant COVID-19 over a total of 23,879 patients with IBD were enrolled …

The Application of Supercritical Fluids Technology to Recover Healthy Valuable Compounds from Marine and Agricultural Food Processing By-Products: A …

2021

Food by-products contain a remarkable source of bioactive molecules with many benefits for humans; therefore, their exploitation can be an excellent opportunity for the food sector. Moreover, the revalorization of these by-products to produce value-added compounds is considered pivotal for sustainable growth based on a circular economy. Traditional extraction technologies have several drawbacks mainly related to the consumption of hazardous organic solvents, and the high temperatures maintained for long extraction periods which cause the degradation of thermolabile compounds as well as a low extraction efficiency of desired compounds. In this context, supercritical fluid extraction (SFE) ha…

Isovector electromagnetic form factors of the nucleon from lattice QCD and the proton radius puzzle

2021

Physical review / D 103(9), 094522 (2021). doi:10.1103/PhysRevD.103.094522

Women’s knowledge and attitudes towards cervical cancer prevention: A qualitative study in the Spanish context

2021

Aims and objectives To explore the knowledge, attitudes and practices related to cervical cancer and its prevention in Spain. Background Worldwide, women's knowledge about cervical cancer is low, and their attitudes towards its prevention are good, but they do not correlate with the screening uptake. Although the rates of Spanish women performing cervical cancer screening are mostly acceptable, their knowledge and attitudes about it have not been explored. Design Qualitative descriptive study. Methods Three focus groups were conducted, with 21 women aged 25 to 65 years. Participants were recruited through convenience sampling. For intragroup homogeneity, women participated in age groups. Th…

La “desconexión digital” a lomos de la seguridad y salud en el trabajo

2021

The preponderance given to teleworking or remote work due to the health crisis is pushing to blur the line that separates effective work time from leisure and rest time. In the end, it practically causes the employee to never disconnect from work. And this is so because Information and Communication Technologies (ICT) push workers to have a constant time and location availability, even outside their working hours. In this sense, communications from bosses, co-workers or even clients through different means like now are not surprising: emails that need an urgent answer, phone calls at untimely hours or, especially in the sense of this article, through the smartphone, either by SMS messages -…

Can new immunoassay techniques improve bladder cancer diagnostics With protein biomarkers?

2021

The search for new diagnostic tests for cancer or ways to improve existing tests is primarily driven by the desire to identify the disease as early as possible. In this report, we summarize the current knowledge of the most promising diagnostic protein bladder cancer (BC) markers reported over the last decade. Unfortunately, analysis of published data suggests that a reliable, highly sensitive biomarker test-system based on ELISA for detecting BC has not yet been developed. The use of more sensitive assays to detect ultra-low concentrations of biomarkers not available for ELISA, could be very beneficial. Based on the literature and pilot experimental data, we conclude that a highly sensitiv…

Targetoid appearance on T2-weighted imaging and signs of tumor vascular involvement: diagnostic value for differentiating HCC from other primary live…

2021

To evaluate targetoid appearance on T2-weighted imaging and signs of tumor vascular involvement as potential new LI-RADS features for differentiating hepatocellular carcinoma (HCC) from other non-HCC primary liver carcinomas (PLCs). This IRB-approved, retrospective study was performed at two liver transplant centers. The final population included 375 patients with pathologically proven lesions imaged between 2007 and 2017 with contrast-enhanced CT or MRI. The cohort consisted of 165 intrahepatic cholangiocarcinomas and 74 combined hepatocellular-cholangiocarcinomas, with the addition of 136 HCCs for control. Two abdominal radiologists (R1; R2) independently reviewed the imaging studies (112…

Ultra-broad spectral photo-response in FePS3 air-stable devices

2021

Van der Waals materials with narrow energy gaps and efficient response over a broadband optical spectral range are key to widen the energy window of nanoscale optoelectronic devices. Here, we characterize FePS as an appealing narrow-gap p-type semiconductor with an efficient broadband photo-response, a high refractive index, and a remarkable resilience against air and light exposure. To enable fast prototyping, we provide a straightforward guideline to determine the thickness of few-layered FePS nanosheets extracted from the optical transmission characteristics of several flakes. The analysis of the electrical photo-response of FePS devices as a function of the excitation energy confirms a …

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2021

Cytomegalovirus (CMV) infection is a major cause of morbidity and mortality following hematopoietic stem cell transplantation (HSCT). Measuring CMV-specific cellular immunity may improve the risk stratification and management of patients. IFN-γ ELISpot assays, based on the stimulation of peripheral blood mononuclear cells with CMV pp65 and IE-1 proteins or peptides, have been validated in clinical settings. However, it remains unclear to which extend the T-cell response to synthetic peptides reflect that mediated by full-length proteins processed by antigen-presenting cells. We compared the stimulating ability of pp65 and IE-1 proteins and corresponding overlapping peptides in 16 HSCT recip…

Flow resistance in mobile bed rills shaped in soils with different texture

2021

Rill erosion is considered one of the most important soil processes because of the large amount of soil loss due to the development of a rill network able to promote an efficient transport of both rill flow-detached particles and those delivered from the inter-rill areas. Rill flow experiments are useful to overcome the gap in rill hydraulics knowledge and to test the reliability of currently applied uniform open channel flow equations for mobile bed rills. In this paper the applicability of a theoretical flow resistance equation, based on a power-velocity profile, to rill channels shaped on soils having different textures was investigated. The measurements (437 runs) of water depth, cross-…

Dataset related to article "Tumor-Derived Prostaglandin E2 Promotes p50 NF-κB-Dependent Differentiation of Monocytic MDSCs"

2021

This record contains data related to article: ""Tumor-Derived Prostaglandin E2 Promotes p50 NF-κB-Dependent Differentiation of Monocytic MDSCs". Myeloid-derived suppressor cells (MDSC) include immature monocytic (M-MDSC) and granulocytic (PMN-MDSC) cells that share the ability to suppress adaptive immunity and to hinder the effectiveness of anticancer treatments. Of note, in response to IFNγ, M-MDSCs release the tumor-promoting and immunosuppressive molecule nitric oxide (NO), whereas macrophages largely express antitumor properties. Investigating these opposing activities, we found that tumor-derived prostaglandin E2 (PGE2) induces nuclear accumulation of p50 NF-…

Combinatorial proofs of two theorems of Lutz and Stull

2021

Recently, Lutz and Stull used methods from algorithmic information theory to prove two new Marstrand-type projection theorems, concerning subsets of Euclidean space which are not assumed to be Borel, or even analytic. One of the theorems states that if $K \subset \mathbb{R}^{n}$ is any set with equal Hausdorff and packing dimensions, then $$ \dim_{\mathrm{H}} π_{e}(K) = \min\{\dim_{\mathrm{H}} K,1\} $$ for almost every $e \in S^{n - 1}$. Here $π_{e}$ stands for orthogonal projection to $\mathrm{span}(e)$. The primary purpose of this paper is to present proofs for Lutz and Stull's projection theorems which do not refer to information theoretic concepts. Instead, they will rely on combinatori…

Abstract PS10-16: Real-world efficacy of ribociclib + aromatase inhibitor/fulvestrant, or endocrine monotherapy, or chemotherapy as first-line treatm…

2021

Abstract Background: In MONALEESA-3 and MONALEESA-7 trials, ribociclib (RIB, a selective CDK4/6 inhibitor) in combination with endocrine therapy (aromatase inhibitor [AI] or fulvestrant [FUL]) demonstrated a significant prolongation of overall survival among patients with breast cancer (BC), regardless of menopausal status and treatment-line. In the premenopausal or perimenopausal women, RIB + AI/FUL should be combined with a luteinizing hormone-releasing hormone agonist. The real-world evidence for the effectiveness, safety, and tolerability of RIB + AI/FUL in the routine clinical practice is needed to support the use of this combination. Methods: RIBANNA is a prospective, non-intervention…

On W.E.B. Du Bois, Double Consciousness, and Racialized Modernity. An Interview with José Itzigsohn

2021

The February issue of Transilvania journal hosts an interview with professor José Itzigsohn focusing on his activity within the field of sociology and his latest book with Karida L. Brown, on The Sociology of W. E. B. Du Bois. Racialized Modernity and the Global Color Line (New York University Press, 2020). It delves into Du Boisian sociology, “double consciousness” and racialized modernity, alongside contemporary decolonial perspectives and new studies and researchers in the field.

Abstract OT-13-06: Solti-1503 PROMETEO: Talimogene laherparepvec (T-VEC) + atezolizumab combination in early breast cancer

2021

Abstract Background Residual disease (RD) after standard neoadjuvant chemotherapy (NAC) is composed of drug resistant cells and associates with increased risk of relapse, especially in triple negative, HER2-positive, and highly proliferative Luminal tumors. Immunotherapy combinations can induce of specific anti-tumor immune responses, such as those mediated by T-cells, and which might represent an additional strategy for the control or elimination of residual tumor cells. Preliminary results in melanoma showed that the combination of T-VEC with an anti PD-L1 or anti CTLA4 has greater efficacy than either therapy alone, without additional safety concerns beyond those expected for each agent.…

Electronic Design for a Bleeding Detector to be Used in Intraoperative Radiotherapy Applications

2021

An electronic design for a bleeding detector used with mobile linac during intraoperative radiotherapy (IORT) is presented. It consists on a readout circuit based on a De Sauty Bridge and a wireless power supply using a supercapacitor. The goal is the measurement of the height of fluid present in the applicator in order to avoid a misadministration dose during the irradiation process. A minimum measurement height of 5 mm is required by clinic to be confident with the selected radiation dose. The measurement circuit uses a capacitive sensor which detects variations lower than 0.1 pF. The readout circuit converts dynamic capacitance variation from the bleeding detector into an analog voltage …

Assessment of the Performance of DFT Functionals Using Off-Diagonal Hypervirial Relationships

2021

Off-diagonal hypervirial relationships, combined with quantum mechanical sum rules of charge-current conservation, offer a way for testing electronic excited-state transition energies and moments, which does not need any external reference. A number of fundamental relations were recast into absolute deviations from zero, which have been used to assess the performance of some popular DFT functionals. Extended TD-DFT calculations have been carried out for a pool of molecules chosen to the purpose, adopting a large basis set to ensure high quality results. A general agreement with previous benchmarks is observed.

Introducing postqualitative inquiry in sport and exercise psychology

2021

In recent years, qualitative research has gained popularity and legitimacy in sport and exercise psychology. However, this scientific discipline has not yet paid attention to postqualitative inquiry (PQI), despite the possibilities it offers for producing different knowledge and producing knowledge differently. The present article is the first attempt to rectify this lack of attention by offering a brief and partial sketch of PQI in the context of sport and exercise psychology. To start with, three of the basic propositions that enable PQI are described. These are: adopt a posthumanist view of ontology and the subject; engage with poststructuralism (necessarily) and new materialism (possibl…

Ythdf is a N6‐methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila

2021

Abstract N6‐methyladenosine (m6A) regulates a variety of physiological processes through modulation of RNA metabolism. This modification is particularly enriched in the nervous system of several species, and its dysregulation has been associated with neurodevelopmental defects and neural dysfunctions. In Drosophila, loss of m6A alters fly behavior, albeit the underlying molecular mechanism and the role of m6A during nervous system development have remained elusive. Here we find that impairment of the m6A pathway leads to axonal overgrowth and misguidance at larval neuromuscular junctions as well as in the adult mushroom bodies. We identify Ythdf as the main m6A reader in the nervous system,…

Abstract PD1-05: Latest findings from the breast cancer cohort in SUMMIT - a phase 2 ‘basket’ trial of neratinib + trastuzumab + fulvestrant for HER2…

2021

Abstract Background: HER2 mutations are oncogenic in hormone receptor positive (HR+) metastatic breast cancer (MBC), and may confer resistance to prior endocrine therapy but retain sensitivity to neratinib. Neratinib is an oral, irreversible, pan-HER tyrosine kinase inhibitor with clinical activity either as a single agent or in combination with fulvestrant in HER2-mutated, HER2-non-amplified MBC. Genomic analyses suggest that acquired resistance to neratinib can occur via additional HER2 alterations, which may alter HER2-pathway signaling. We investigated whether dual HER2-targeted therapy could improve clinical benefit in a cohort of patients with HER2-mutant, HR+ MBC treated with neratin…

Differences in health status, health behaviour and healthcare utilisation between Immigrant and native homeless people in Spain: An exploratory study

2021

Few studies have examined the differences between immigrant and native-born homeless populations. Our aim was to conduct an exploratory study to examine the differences in health status, health behaviour and healthcare utilisation in a sample of Spanish immigrant and native homeless people. Study was conducted in eight different temporary accommodations in the Valencia region in August 2018. Overall, 86 participants were included in the analysis who answered questionnaires concerning socio-demographic characteristics, immigration status, health status and behaviour, healthcare utilisation and experienced discrimination in healthcare and health literacy. In total, 76.7% were men with a mean …

Abstract PD1-02: A phase I/Ib study evaluating GDC-0077 + palbociclib (palbo) + fulvestrant in patients (pts) with PIK3CA-mutant (mut), hormone recep…

2021

Abstract Background GDC-0077 is a PI3Kα-selective inhibitor and mutant PI3Kα degrader that demonstrates antitumor activity in PIK3CAmut BC xenograft models. A phase I/Ib study of GDC-0077 alone and combined with endocrine therapy ± the CDK4/6 inhibitor (i) palbo is ongoing (NCT03006172). Data from GDC-0077 + palbo + fulvestrant in pts with PIK3CAmut, HR+/HER2- mBC are presented herein. Methods Safety (NCI-CTCAE v4), pharmacokinetics (PK), and preliminary antitumor activity (clinical benefit rate [CBR]: RECIST v1.1 stable disease for ≥ 24 weeks, partial response [PR], or complete response) of 9 mg oral once daily GDC-0077 + 125 mg palbo 21/28 days + 500 mg intramuscular fulvestrant on day 1 …

Frequent blood flow restricted training not to failure and to failure induces similar gains in myonuclei and muscle mass

2021

The purpose of the present study was to compare the effects of short-term high-frequency failure vs non-failure blood flow–restricted resistance exercise (BFRRE) on changes in satellite cells (SCs), myonuclei, muscle size, and strength. Seventeen untrained men performed four sets of BFRRE to failure (Failure) with one leg and not to failure (Non-failure; 30-15-15-15 repetitions) with the other leg using knee-extensions at 20% of one repetition maximum (1RM). Fourteen sessions were distributed over two 5-day blocks, separated by a 10-day rest period. Muscle samples obtained before, at mid-training, and 10-day post-intervention (Post10) were analyzed for muscle fiber area (MFA), myonuclei, an…

Abstract PS11-05: Updated data from SERENA-1: A Phase 1 dose escalation and expansion study of the next generation oral SERD AZD9833 as a monotherapy…

2021

Abstract Background: AZD9833 is an oral selective estrogen receptor (ER) antagonist and degrader (SERD) in Phase 2 clinical development for the treatment of ER+ HER2− breast cancer. Here we report data from Parts C and D of the ongoing Phase 1 study (SERENA-1) examining AZD9833 in combination with palbociclib, together with updated data from Parts A and B examining AZD9833 monotherapy. Methods: SERENA-1 (NCT03616587) is an ongoing open-label Phase 1 study of AZD9833 in pre- and post-menopausal women with ER+, HER2− advanced breast cancer who have previously received ≥1 endocrine therapy and ≤2 prior chemotherapies. Prior treatment with fulvestrant and/or CDK4/6 inhibitors was permitted. The…

One hundred and fifty years of ornithology in Sicily, with an unknown manuscript by Joseph Whitaker

2021

A new complete check-list of Birds of Sicily is presented in this paper, with a comparison with previous lists for a period of one hundred and fifty years. Further, an unknown manuscript by Joseph Whitaker “Birds of Sicily”, dated back to ca. 1920, has been transcribed and is here presented integrally. Thus, lists of birds here presented have been separated as follows: i) Doderlein (1869–1874); ii) Whitaker (1920); iii) Iapichino & Massa (1989), Lo Valvo et al. (1993) iv) Corso (2005), Ientile & Massa (2008); v) 2010–2020: Massa et al. (2015) and personal observations; vi) long-term trend: personal observations. Overall, 437 species are listed. Out of 283 species regularly present i…

Photochemically induced dynamic nuclear polarization of heteronuclear singlet order

2021

Photochemically induced dynamic nuclear polarization (photo-CIDNP) is a method to hyperpolarize nuclear spins using light. In most cases, CIDNP experiments are performed in high magnetic fields and the sample is irradiated by light inside a nuclear magnetic resonance (NMR) spectrometer. Here we demonstrate photo-CIDNP hyperpolarization generated in the Earth's magnetic field and under zero- to ultralow-field (ZULF) conditions. Irradiating a sample containing tetraphenylporphyrin and para-benzoquinone for several seconds with light-emitting diodes produces strong hyperpolarization of 1H and 13C nuclear spins, enhancing the NMR signals more than 200 times. The hyperpolarized spin states at th…

Countertransference responses mediate the relationship between patients' overall defense functioning and therapists' interventions.

2021

Objective: The aim of this work was to investigate the relationship between therapists' techniques (supportive/expressive intervention level - ESIL), therapists' countertransference (CT) and patients' defense level of functioning (ODF). We hypothesized that CT could play a mediating role in the relationship between patients' ODF and therapists' ESIL. Method: 65 psychotherapy sessions were rated by two different raters each with the Psychodynamic Interventions Rating Scale and the Defense Mechanisms Rating Scale. Clinicians used the Therapist Response Questionnaire to provide information on their CT. The 65 sessions referred to 65 clinicians (25 = females, 40 = males; 38 = psychodynamic, 27 …

LES TEXTES DE PRÉSENTATION DES DICTIONNAIRES DE COMMERCE BILINGUES ITALIEN-FRANÇAIS ET FRANÇAIS-ITALIEN ÉDITÉS EN ITALIE

2021

Dans cet article, l’on examine les caracteristiques fondamentales des discours de presentation des dictionnaires de commerce bilingues italien-francais et francais-italien publies en Italie. Le corpus etudie permet de mettre en exergue les fonctions et les aspects principaux des textes de presentation, notamment les motivations des auteurs, le public vise, la macrostructure et les sources utilisees. L’analyse du corpus souligne les points communs et les quelques dissemblances de cette typologie de dictionnaires, outre l’importance qu’ils detiennent au sein de l’enseignement de la langue francaise de specialite.

Unravelling the Intertwined Atomic and Bulk Nature of Localised Excitons by Attosecond Spectroscopy

2021

The electro-optical properties of most semiconductors and insulators of technological interest are dominated by the presence of electron-hole quasi-particles, called excitons. The manipulation of excitons in dielectrics has recently received great attention, with possible applications in different fields including optoelectronics and photonics. Here, we apply attosecond transient reflection spectroscopy in a sequential two-foci geometry and observe sub-femtosecond dynamics of a core-level exciton in bulk MgF2 single crystals. Furthermore, we access absolute phase delays, which allow for an unambiguous comparison with theoretical calculations. Our results show that excitons surprisingly exhi…