Abstract PS11-05: Updated data from SERENA-1: A Phase 1 dose escalation and expansion study of the next generation oral SERD AZD9833 as a monotherapy…

2021

Abstract Background: AZD9833 is an oral selective estrogen receptor (ER) antagonist and degrader (SERD) in Phase 2 clinical development for the treatment of ER+ HER2− breast cancer. Here we report data from Parts C and D of the ongoing Phase 1 study (SERENA-1) examining AZD9833 in combination with palbociclib, together with updated data from Parts A and B examining AZD9833 monotherapy. Methods: SERENA-1 (NCT03616587) is an ongoing open-label Phase 1 study of AZD9833 in pre- and post-menopausal women with ER+, HER2− advanced breast cancer who have previously received ≥1 endocrine therapy and ≤2 prior chemotherapies. Prior treatment with fulvestrant and/or CDK4/6 inhibitors was permitted. The…

LES TEXTES DE PRÉSENTATION DES DICTIONNAIRES DE COMMERCE BILINGUES ITALIEN-FRANÇAIS ET FRANÇAIS-ITALIEN ÉDITÉS EN ITALIE

2021

Dans cet article, l’on examine les caracteristiques fondamentales des discours de presentation des dictionnaires de commerce bilingues italien-francais et francais-italien publies en Italie. Le corpus etudie permet de mettre en exergue les fonctions et les aspects principaux des textes de presentation, notamment les motivations des auteurs, le public vise, la macrostructure et les sources utilisees. L’analyse du corpus souligne les points communs et les quelques dissemblances de cette typologie de dictionnaires, outre l’importance qu’ils detiennent au sein de l’enseignement de la langue francaise de specialite.

Unravelling the Intertwined Atomic and Bulk Nature of Localised Excitons by Attosecond Spectroscopy

2021

The electro-optical properties of most semiconductors and insulators of technological interest are dominated by the presence of electron-hole quasi-particles, called excitons. The manipulation of excitons in dielectrics has recently received great attention, with possible applications in different fields including optoelectronics and photonics. Here, we apply attosecond transient reflection spectroscopy in a sequential two-foci geometry and observe sub-femtosecond dynamics of a core-level exciton in bulk MgF2 single crystals. Furthermore, we access absolute phase delays, which allow for an unambiguous comparison with theoretical calculations. Our results show that excitons surprisingly exhi…

An overview of the geochemical characteristics of oceanic carbonatites: New insights from Fuerteventura carbonatites (Canary islands)

2021

The occurrence of carbonatites in oceanic settings is very rare if compared with their continental counterpart, having been reported only in Cape Verde and Canary Islands. This paper provides an overview of the main geochemical characteristics of oceanic carbonatites, around which many debates still exist regarding their petrogenesis. We present new data on trace elements in minerals and whole-rock, together with the first noble gases isotopic study (He, Ne, Ar) in apatite, calcite, and clinopyroxene from Fuerteventura carbonatites (Canary Islands). Trace elements show a similar trend as Cape Verde carbonatites, almost tracing the same patterns on multi-element and REE abundance diagrams. 3…

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2021

(1) Background: The use of social media has become an integral part of adolescents’ daily lives. However, the intensive use of social media can develop into a health-threatening addiction, but unfavourable health consequences can occur even with less use. Social media user groups categorized as no-risk, moderate risk (of developing problematic behaviour), and problematic use were examined with reference to their prevalence, their associations with individual determinants and health, and the increased health risk between groups. (2) Methods: The Finnish nationally representative HBSC data (persons aged 11, 13, and 15, n = 3408) and descriptive and binary logistic regression analysis were app…

Self-organised structures in the field of ICT : challenges for employees’ workplace learning

2021

PurposeThe purpose of this study is to identify the challenges of low hierarchy and self-organised structures for employees’ learning and competency development at work. In the past decade, interest in employees’ and organisations’ self-directedness has increased. Self-organised structures are perceived as better able to answer to the quickly changing requirements of clients and business environments. Within these structures, employees are expected to take on more responsibility and maintain more control over their workplace learning, which means they must be self-directed and autonomous. An important question for this approach is how can workplace learning and employee competence developme…

Abstract OT-31-01: A phase II study to evaluate the efficacy and safety of pembrolizumab plus carboplatin in BRCA-related metastatic breast cancer: P…

2021

Abstract Background Considering the high proportion of tumor-infiltrating lymphocytes (TILs) in BRCA-related breast cancer, we expect that PD-1 pathway is highly expressed and PD-1 antagonist pembrolizumab could provide clinical activity in this kind of tumor. Furthermore, BRCA-related breast cancers are known to be more sensitive to platinum-derived drugs. Thus the association between Pembrolizumab and Carboplatin in metastatic BRCA-related breast cancer seems to be active in this setting of patients. This study will evaluate the safety and the efficacy of Pembrolizumab associated with Carboplatin in BRCA mutated or with unknown mutations metastatic breast cancer patients. Study and Statis…

Mathematical properties of nested residues and their application to multi-loop scattering amplitudes

2021

Journal of high energy physics 02(2), 112 (2021). doi:10.1007/JHEP02(2021)112

Some results on the rotated infinitely deep potential and its coherent states

2021

The Swanson model is an exactly solvable model in quantum mechanics with a manifestly non self-adjoint Hamiltonian whose eigenvalues are all real. Its eigenvectors can be deduced easily, by means of suitable ladder operators. This is because the Swanson Hamiltonian is deeply connected with that of a standard quantum Harmonic oscillator, after a suitable rotation in configuration space is performed. In this paper we consider a rotated version of a different quantum system, the infinitely deep potential, and we consider some of the consequences of this rotation. In particular, we show that differences arise with respect to the Swanson model, mainly because of the technical need of working, he…

Dataset related to article "Tumor-Derived Prostaglandin E2 Promotes p50 NF-κB-Dependent Differentiation of Monocytic MDSCs"

2021

This record contains data related to article: ""Tumor-Derived Prostaglandin E2 Promotes p50 NF-κB-Dependent Differentiation of Monocytic MDSCs". Myeloid-derived suppressor cells (MDSC) include immature monocytic (M-MDSC) and granulocytic (PMN-MDSC) cells that share the ability to suppress adaptive immunity and to hinder the effectiveness of anticancer treatments. Of note, in response to IFNγ, M-MDSCs release the tumor-promoting and immunosuppressive molecule nitric oxide (NO), whereas macrophages largely express antitumor properties. Investigating these opposing activities, we found that tumor-derived prostaglandin E2 (PGE2) induces nuclear accumulation of p50 NF-…

Abstract PD1-02: A phase I/Ib study evaluating GDC-0077 + palbociclib (palbo) + fulvestrant in patients (pts) with PIK3CA-mutant (mut), hormone recep…

2021

Abstract Background GDC-0077 is a PI3Kα-selective inhibitor and mutant PI3Kα degrader that demonstrates antitumor activity in PIK3CAmut BC xenograft models. A phase I/Ib study of GDC-0077 alone and combined with endocrine therapy ± the CDK4/6 inhibitor (i) palbo is ongoing (NCT03006172). Data from GDC-0077 + palbo + fulvestrant in pts with PIK3CAmut, HR+/HER2- mBC are presented herein. Methods Safety (NCI-CTCAE v4), pharmacokinetics (PK), and preliminary antitumor activity (clinical benefit rate [CBR]: RECIST v1.1 stable disease for ≥ 24 weeks, partial response [PR], or complete response) of 9 mg oral once daily GDC-0077 + 125 mg palbo 21/28 days + 500 mg intramuscular fulvestrant on day 1 …

Photochemically induced dynamic nuclear polarization of heteronuclear singlet order

2021

Photochemically induced dynamic nuclear polarization (photo-CIDNP) is a method to hyperpolarize nuclear spins using light. In most cases, CIDNP experiments are performed in high magnetic fields and the sample is irradiated by light inside a nuclear magnetic resonance (NMR) spectrometer. Here we demonstrate photo-CIDNP hyperpolarization generated in the Earth's magnetic field and under zero- to ultralow-field (ZULF) conditions. Irradiating a sample containing tetraphenylporphyrin and para-benzoquinone for several seconds with light-emitting diodes produces strong hyperpolarization of 1H and 13C nuclear spins, enhancing the NMR signals more than 200 times. The hyperpolarized spin states at th…

Abstract PS11-11: Targeted safety events from a phase I/Ib study evaluating GDC-0077 alone and in combination with endocrine therapy (ET) ± palbocicl…

2021

Abstract Background Activating mutations in PIK3CA, encoding the p110α subunit of phosphatidylinositol 3-kinase (PI3K) occur in ~40% of HR+/HER2- BCs. GDC-0077, a PI3Kα-selective inhibitor and mutant PI3Kα degrader, is being developed as an anticancer agent. A phase I/Ib study of GDC-0077 alone and combined with other therapies is ongoing in pts with locally advanced or metastatic PIK3CAmut, HR+/HER2- mBC (NCT03006172). Targeted safety events are presented here. Methods Safety was assessed via NCI-CTCAE v4 for GDC-0077 administered alone (Arm A), with letrozole and palbo (Arm B), with letrozole (Arm C), with fulvestrant (Arm D), or with fulvestrant and palbo (Arm E, plus metformin in Arm F …

The “unnatural” history of colorectal cancer in Lynch syndrome : lessons from colonoscopy surveillance

2021

Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at increased risk of developing malignancies, in particular colorectal cancer (CRC). Regular colonoscopy with polypectomy is recommended to reduce CRC risk in LS individuals. However, recent independent studies demonstrated that a substantial proportion of LS individuals develop CRC despite regular colonoscopy. The reasons for this surprising observation confirmed by large prospective studies are a matter of debate. In this review, we collect existing evidence from clinical, epidemiological and molecular studies and interpret them with regard to the origins and progression of LS-associated CRC. Alon…

Author response: Right inferior frontal gyrus implements motor inhibitory control via beta-band oscillations in humans

2021

The Application of Supercritical Fluids Technology to Recover Healthy Valuable Compounds from Marine and Agricultural Food Processing By-Products: A …

2021

Food by-products contain a remarkable source of bioactive molecules with many benefits for humans; therefore, their exploitation can be an excellent opportunity for the food sector. Moreover, the revalorization of these by-products to produce value-added compounds is considered pivotal for sustainable growth based on a circular economy. Traditional extraction technologies have several drawbacks mainly related to the consumption of hazardous organic solvents, and the high temperatures maintained for long extraction periods which cause the degradation of thermolabile compounds as well as a low extraction efficiency of desired compounds. In this context, supercritical fluid extraction (SFE) ha…

SIGNIFICANCE FOR INTERNATIONAL CORRELATION OF THE PERAPERTÚ FORMATION IN NORTHERN PALENCIA, CANTABRIAN MOUNTAINS. TECTONIC/STRATIGRAPHIC CONTEXT AND …

2021

Small ammonoid assemblages are recorded from the Perapertú Formation in northern Palencia. This is a mudstone unit with local platform limestones characterised by carbonate debris flows on the limestone margins. This unit, of Late Bashkirian to Early Moscovian age, participates in a series of southwards verging thrust slicesNorth of a major fault zone which originated as the head (leading edge) of a large thrust sheet with an internal deformation consisting of thrust slices and at least one nappe structure. Opposed vergencies at the head of this major thrust sheet (Carrionas Thrust Front) and the Ruesga Fault which locally modifies its trace, mark the position where the northern branch of t…

Levels of genetic differentiation and gene flow between four populations of the Scaly-naped Pigeon, Patagioenas squamosa : implications for conservat…

2021

Island-endemic columbid species are particularly vulnerable to environmental degradation, extreme climatic events, and interactions with exotic species. The situation might be even more critical in the case of exploited species, where legal hunting and poaching can severely affect population dynamics. Here we document for the first time the genetic structure of the Scaly-naped Pigeon, Patagioenas squamosa, a Caribbean-endemic columbid species of cynegetic interest, over a large part of its range. Using both mitochondrial DNA and nuclear markers (microsatellites), we investigated gene flow, genetic diversity, and genetic structure among four islands populations originating from Puerto-Rico, …

Optical activation of TrkB neurotrophin receptor in mouse ventral hippocampus promotes plasticity and facilitates fear extinction

2021

AbstractSuccessful extinction of traumatic memories depends on neuronal plasticity in the fear extinction network. However, the mechanisms involved in the extinction process remain poorly understood. Here, we investigated the fear extinction network by using a new optogenetic technique that allows temporal and spatial control of neuronal plasticity in vivo. We optimized an optically inducible TrkB (CKII-optoTrkB), the receptor of the brain-derived neurotrophic factor, which can be activated upon blue light exposure to increase plasticity specifically in pyramidal neurons. The activation of CKII-optoTrkB facilitated the induction of LTP in Schaffer collateral-CA1 synapses after brief theta-b…

Sirolimus versus cyclosporine in haploidentical stem cell transplantation with posttransplant cyclophosphamide and mycophenolate mofetil as graft‐ver…

2021

Sirolimus has emerged as an alternative to calcineurin inhibitors-based (CNI) graft-versus-host disease (GVHD) prophylaxis. This retrospective study compares the outcome of 133 consecutive adult patients with haematological malignancies undergoing haploidentical stem cell transplantation with posttransplant cyclophosphamide (PTCy) and mycophenolate mofetil (MMF), combined with cyclosporine A (PTCy-CsA-MMF,

Recesión: Schroeder, R. & Perejón, A. (eds.) 2006. Contributions to the geology of Spain in memory of Prof. Franz Lotze. Zeitschrift der Deutsche…

2021

Recientemente se ha publicado un número especial en Memoria del Prof. Franz Lotze (1903-1971), editado por los doctores Rolf Schroeder (Frankfurt am Main) y Antonio Perejón (Madrid), consta de 12 contribuciones sobre distintas cuestiones geológicas de la Península Ibérica, a las que se añanden una interesante panorámica del trabajo geológico de Lotze en España, elaborado por los editores, y un sentido prólogo del Prof. Jaime Truyols (Oviedo).

Total Nut, Tree Nut, and Peanut Consumption and Metabolic Status in Southern Italian Adults.

2021

Background: Nut consumption has been associated with cardio-metabolic health benefits. However, studies conducted in the Southern Italian population, where adherence to the Mediterranean diet has been reported being relatively high, are rather scarce. The aim of this study was to test the association between consumption of total and specific types of nuts and metabolic status among adults living in Sicily, Southern Italy. Methods: Demographic and dietary characteristics of 2044 adults living in Southern Italy were analyzed. Multivariate logistic regression analyses were performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) of the association between nut consumption and…

Ansiedad ante la muerte y felicidad en futuros docentes

2021

El bienestar psicologico y la felicidad son aspectos deseables en cualquier individuo, pero es especialmente relevante en el caso de los docentes por su impacto en el desarrollo holistico de los educandos. Este bienestar toma un nuevo matiz cuando el docente ha de abordar tematicas complejas como puede ser el duelo o la muerte. Bajo esta perspectiva, el presente estudio trata de analizar la correlacion entre el bienestar subjetivo y la ansiedad ante la muerte de los futuros docentes. Para ello, se ha utiliza un diseno mixto, utilizando dos instrumentos validados y una serie de preguntas abiertas que han sido cumplimentados por 87 estudiantes (n=87) del Grado en Educacion Primaria de la Univ…

Phenomenology of fermion dark matter as neutrino mass mediator with gauged B-L

2021

We analyze a model with unbroken B-L gauge symmetry where neutrino masses are generated at one loop, after spontaneous breaking of a global U(1) symmetry. These symmetries ensure dark matter stability and the Diracness of neutrinos. Within this context, we examine fermionic dark matter. Consistency between the required neutrino mass and the observed relic abundance indicates dark matter masses and couplings within the reach of direct detection experiments.

LOCHKOVIAN TO PRAGIAN (LOWER DEVONIAN) NERITIC OSTRACODES FROM NIGÜELLA (ZARAGOZA, IBERIAN CHAINS, NE SPAIN)

2021

Lochkovian and Pragian ostracodes from the area of Niguella (Iberian Chains), which is a key area for supra-regional correlation in the Early Devonian, are described for the first time. 12 ostracode taxa from the sections Ni4 and Ni2 could be identified. The silicified ostracodes of Eifelian Ecotype are low in biodiversity, have few individuals, and are comparatively poorly preserved. Characteristic taxa of the Devonian occur. Thus, the faunas show general relations to most European Early Devonian ostracode faunas. Closer relations exist to the Eastern Guadarrama. Polyzygia kroemmelbeini LeFevre & Weyant, 1967 and P. grekoffi Weyant, 1980 are found in the basal Pragian for the first time. B…

Introducing mindfulness and compassion‐based interventions to improve verbal creativity in students of clinical and health psychology

2021

OBJECTIVES In the field of psychotherapy, verbal creativity has been suggested as an important aspect in psychotherapists' training. In the present study, the effects of a mindfulness and compassion-based intervention (MCBI) on verbal creativity are analysed in students of clinical and health psychology (N = 90). DESIGN Students were randomly assigned to an experimental group (n = 37), in which an MCBI was applied, and a waiting list group (n = 26) with no intervention. We also assessed a non-randomized active control group (n = 27), in which students received training in basic psychotherapy skills. METHODS Verbal creativity (fluency, flexibility, and originality) was evaluated in a pre-, p…

Pterostilbene in Cancer Therapy.

2021

Natural polyphenols are organic chemicals which contain phenol units in their structures and possess antitumor properties. However, a key problem is their short half-life and low bioavailability under in vivo conditions. Pterostilbene (3,5-dimethoxy-4′-hydroxystilbene; PT) is a phytoalexin originally isolated from the heartwood of red sandalwood. As recently reported by our group, PT was shown to be effective in the treatment of melanoma. Counterintuitively, PT is not effective (cytotoxic) against melanoma in vitro, and only under in vivo conditions does PT display its anticancer activity. This study elucidated that PT can be effective against melanoma through the inhibition of adrenocortic…

FE DE ERRATAS / ERRATUM

2021

Please make the following correction in the previous issue. López-Martínez, N., Likius, A., Mackaye, H. T., Vignaud, P. & Brunet, M. 2007. A new Lagomorph from the Late Miocene of Chad (Central Africa). Revista Española de Paleontología, 22 (1), 1-20.

Fight against social exclusion and poverty. The necessary ratification in spain of the revised european social charter and its additional protocol pr…

2021

El presente trabajo tiene como principal objetivo presentar la pobreza y la exclusión social como una vulneración de los derechos humanos, a través del análisis del artículo 30 de la Carta Social Europea revisada y de parte de la jurisprudencia emanada del Comité Europeo de Derechos Sociales. Dicha norma, sin ratificar aún por España, supondría un refuerzo del sistema de protección de los derechos sociales en nuestro país que pasa por una preocupante situación social, dados los alarmantes niveles de pobreza que aún persisten The main objective of this paper is to present poverty and social exclusion as a violation of human rights, through the analysis of article 30 of the revised European S…

Trabajo precario en empresas multiservicios: una propuesta de solución legal

2021

espanolEl presente trabajo plantea una propuesta de solucion a la situacion de precariedad en la que prestan servicios miles de personas trabajadoras que son contratadas por empresas multiservicios que las ponen a disposicion de otras empresas en el marco de una contrata de servicios que se situa en la frontera de la cesion ilegal EnglishThis work raises a solution proposal to the situacion of precariousness in wich thousands of workers are contracted by multiservice companies that make them available to other companies within the framework of a contract of services that is situated on the border of ilegal cession

Hormonal stress responses of growth hormone and insulin-like growth factor-I in highly resistance trained women and men

2021

Abstract The purpose of this study was to examine the responses of growth hormone (GH) and insulin-like growth factor-I (IGF I) to intense heavy resistance exercise in highly trained men and women to determine what sex-dependent responses may exist. Subjects were highly resistance trained men (N = 8, Mean ± SD; age, yrs., 21 ± 1, height, cm, 175.3 ± 6.7, body mass, kg, 87.0 ± 18.5, % body fat, 15.2 ± 5.4, squat X body mass, 2.1 ± 0.4; and women (N = 7; Mean ± SD, age, yrs. 24 ± 5, height, cm 164.6 ± 6.7, body mass, kg 76.4 ± 8.8, % body fat, 26.9 ± 5.3, squat X body mass, 1.7 ± 0.6). An acute resistance exercise test protocol (ARET) consisted of 6 sets of 10 repetitions at 80% of the 1 RM w…

Stochastic sensitivity of bull and bear states

2021

We study the price dynamics generated by a stochastic version of a Day–Huang type asset market model with heterogenous, interacting market participants. To facilitate the analysis, we introduce a methodology that allows us to assess the consequences of changes in uncertainty on the dynamics of an asset price process close to stable equilibria. In particular, we focus on noise-induced transitions between bull and bear states of the market under additive as well as parametric noise. Our results are obtained by combining the stochastic sensitivity function (SSF) approach, a mixture of analytical and numerical techniques, due to Mil’shtein and Ryashko (1995) with concepts and techniques from th…

Numerical Analysis of Bearing Capacity of a Ring Footing on Geogrid Reinforced Sand

2021

A ring footing is found to be of practical importance in supporting symmetrical constructions for example silos, oil storage container etc. In the present paper, numerical analysis was carried out with explicit code FLAC3D 7.0 to investigate bearing capacity of a ring footing on geogrid reinforced sand. Effects of the ratio n of its inner/outer diameter (Di/D) of a ring footing, an optimum depth to lay the geogrid layer were examined. It was found that an intersection zone was developed in soil under inner-side (aisle) of ring footing, contributing to its bearing capacity. Substantial increase of bearing capacities could be realized if ratio n of a ring footing was around 0.6. Numerical res…

Cladding-Pumped Erbium/Ytterbium Co-Doped Fiber Amplifier for C-Band Operation in Optical Networks

2021

Space-division multiplexing (SDM) attracts attention to cladding-pumped optical amplifiers, but they suffer from a low pump power conversion efficiency. To address this issue, ytterbium (Yb3+) and erbium (Er3+) co-doping is considered as an effective approach. However, it changes the gain profile of Er3+-doped fiber amplifiers and induces the gain difference between optical wavelengths in the C-band, significantly limiting the effective band of the dense wavelength-division multiplexed (DWDM) system. This paper is devoted to a detailed study of a cladding-pumped Er3+/Yb3+ co-doped fiber amplifier (EYDFA) through numerical simulations aiming to identify a configuration, before assembling a s…

Sella, A NEW NAME FOR THE GENUS Linaresia EL KADIRI, 1992 (NASSELLARIA, RADIOLARIA) PREOCCUPIED BY COPEPOD CRUSTACEANS (LAMIPPIDAE, MAXILLOPODA)

2021

The aim of this short note is to create a new name of this genus since the original name Linaresia proved to pre-exist in the paleontological literature ( Linaresia de Zulueta, 1908, Family Lamippidae, Copepod crustaceans, and Linaresia Gonzalez-Donoso, 1968, Family Gavelinellidae, Agglutinated Foraminifera). The new name created for the above mentioned radiolarians is: Sella . This name derives from an arbitrary combination of letters (International Code of Zoological Nomenclature). The type species of Sella is S. beniderkoulensis by original designation (El Kadiri, 1992).

AKT3 Expression in Mesenchymal Colorectal Cancer Cells Drives Growth and Is Associated with Epithelial-Mesenchymal Transition

2021

Simple Summary Colorectal cancer can be subdivided into four distinct subtypes that are characterised by different clinical features and responses to therapies currently used in the clinic to treat this disease. One of those subtypes, called CMS4, is associated with a worse prognosis and poor response to therapies compared to other subtypes. We therefore set out to explore what proteins are differentially expressed and used in CMS4 to find potential new targets for therapy. We found that protein AKT3 is highly expressed in CMS4, and that active AKT3 inhibits a protein that stalls growth of cancer cells (p27KIP1). We can target AKT3 with inhibitors which leads to strongly reduced growth of c…