showing 36 of ~574560 from 574555 documents
Data-Driven Clustering Approach to Derive Taste Perception Profiles from Sweet, Salt, Sour, Bitter, and Umami Perception Scores: An Illustration amon…
2021
BACKGROUND Current approaches to studying relations between taste perception and diet quality typically consider each taste-sweet, salt, sour, bitter, umami-separately or aggregately, as total taste scores. Consistent with studying dietary patterns rather than single foods or total energy, an additional approach may be to study all 5 tastes collectively as "taste perception profiles." OBJECTIVE We developed a data-driven clustering approach to derive taste perception profiles from taste perception scores and examined whether profiles outperformed total taste scores for capturing individual variability in taste perception. METHODS The cohort included 367 community-dwelling adults [55-75 y; 5…
Evolutionary relationships, biogeography and morphological characters of Glinus (Molluginaceae), with special emphasis on the genus composition in Su…
2021
Glinus is a small genus of Molluginaceae with 8–10 species mostly distributed in the tropics of the World. Its composition and evolutionary relationships were poorly studied. A new molecular phylogeny constructed here using nuclear (ITS) and chloroplast (rbcL, trnK-matK) markers confirmed the monophyly of the genus. Based on ITS analysis, the following well-supported lineages are present within Glinus: the G. bainesii lineage is recovered as sister to the remainder of the genus followed by G. oppositifolius. Three other clades are: G. hirtus with G. orygioides; G. radiatus and G. lotoides; the latter is represented by a sample from North America, and G. zambesiacus as sister to G. setifloru…
Ceftazidime-avibactam use for klebsiella pneumoniae carbapenemase-producing k. pneumoniae infections: A retrospective observational multicenter study
2021
Abstract Background A growing body of observational evidence supports the value of ceftazidime-avibactam (CAZ-AVI) in managing infections caused by carbapenem-resistant Enterobacteriaceae. Methods We retrospectively analyzed observational data on use and outcomes of CAZ-AVI therapy for infections caused by Klebsiella pneumoniae carbapenemase–producing K. pneumoniae (KPC-Kp) strains. Multivariate regression analysis was used to identify variables independently associated with 30-day mortality. Results were adjusted for propensity score for receipt of CAZ-AVI combination regimens versus CAZ-AVI monotherapy. Results The cohort comprised 577 adults with bloodstream infections (n = 391) or nonba…
Paula Galenieka disertācija “Latvijas rozes”
2021
Atzīmējot botāniķa Paula Galenieka (1891-1962) 130 gadu jubileju par LU Muzeja 2021. gada februāra mēneša priekšmetu tika izvēlēts muzeja jaunieguvums profesora disertācija “Latvijas rozes”, kas tika aizstāvēta 1936. gadā. Rakstā sniegts ieskats par disertāciju un tās tapšanu.
Role of the IL-23/IL-17 Pathway in Rheumatic Diseases: An Overview
2021
Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19) and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced by macrophages and dendritic cells, in response to exogenous or endogenous signals, and drives the differentiation and activation of T helper 17 (Th17) cells with subsequent production of IL-17A, IL-17F, IL-6, IL-22, and tumor necrosis factor α (TNF-α). Although IL-23 plays a pivotal role in the protective immune response to bacterial and fungal infections, its dysregulation has been shown to exacerbate chronic immune-mediated inflammation. Well-established experimental data support the concept that IL-23/IL…
The Chain of Control in Results-based Management in Finnish Universities*
2021
This chapter deals with the results-based management implemented in Finnish universities as a part of the neo-liberal managerial idea of a “corporate university.” Analyzing the entire chain of control – from the government level (planning) to the university level (performance management) before finally addressing the personnel level (perceptions of control) – the chapter acknowledges the conflicting views of different stakeholders and the potential for confrontation concerning the different goals as reflected by performance measurement. The key findings of the chapter indicate that the chain of control does not function as planned – that the perceptions and intentions of control among stake…
Akadēmiķa Jāņa Endzelīna 148. dzimšanas dienas atceres starptautiskā zinātniskā konference "Baltijas onīmi: no sendienām līdz mūsdienām". Tēzes
2021
Tēžu krājumā apvienotas LU Latviešu valodas institūta rīkotās akadēmiķa Jāņa Endzelīna (1873–1961) 148. dzimšanas dienas atcerei veltītās starptautiskās zinātniskās konferences tēzes, kuras iesnieguši 20 konferences dalībnieki no Latvijas, Lietuvas, Vācijas. Akadēmiķa atceres konferences tiek rīkotas jau kopš 1963. gada. 2021. gada 22. februāra konference tika veltīta onomastikai: “Baltijas onīmi: no sendienām līdz mūsdienām”. Konferences tēžu krājuma tēmu loks ir plašs: no vietvārdu, personvārdu un literārās onomastikas pētījumiem līdz īpašvārdu ontoloģijas un terminoloģijas jautājumiem.
An integrated approach for the HCl and metals recovery from waste pickling solutions: pilot plant and design operations
2021
Abstract Continuous regeneration of industrial pickling solutions and recovery of valuable materials are implemented in a pilot-scale plant including diffusion dialysis (DD), where HCl is recovered, membrane distillation (MD), where HCl is concentrated, and reactive precipitation (CSTR), where metal ions are recovered in different forms. The integration of the three processes allows to minimize waste streams generation and to accomplish a closed-loop process, thus increasing the environmental sustainability and economic impact of the galvanizing industry. Process reliability was proved through the operation of a demonstrator in the real industrial environment of the Tecnozinco SrL hot-dip g…
Radiation Hardness Assurance Through System-Level Testing: Risk Acceptance, Facility Requirements, Test Methodology, and Data Exploitation
2021
International audience; Functional verification schemes at a level different from component-level testing are emerging as a cost-effective tool for those space systems for which the risk associated with a lower level of assurance can be accepted. Despite the promising potential, system-level radiation testing can be applied to the functional verification of systems under restricted intrinsic boundaries. Most of them are related to the use of hadrons as opposed to heavy ions. Hadrons are preferred for the irradiation of any bulky system, in general, because of their deeper penetration capabilities. General guidelines about the test preparation and procedure for a high-level radiation test ar…
A Relational Tsetlin Machine with Applications to Natural Language Understanding
2021
TMs are a pattern recognition approach that uses finite state machines for learning and propositional logic to represent patterns. In addition to being natively interpretable, they have provided competitive accuracy for various tasks. In this paper, we increase the computing power of TMs by proposing a first-order logic-based framework with Herbrand semantics. The resulting TM is relational and can take advantage of logical structures appearing in natural language, to learn rules that represent how actions and consequences are related in the real world. The outcome is a logic program of Horn clauses, bringing in a structured view of unstructured data. In closed-domain question-answering, th…
Frontispiz: Metallfreie, elektrochemische Synthese von Sulfonamiden direkt aus (Hetero)arenen, SO 2 und Aminen
2021
Implementation of local chiral interactions in the hyperspherical harmonics formalism
2021
With the goal of using chiral interactions at various orders to explore properties of the few-body nuclear systems, we write the recently developed local chiral interactions as spherical irreducible tensors and implement them in the hyperspherical harmonics expansion method. We devote particular attention to three-body forces at next-to-next-to leading order, which play an important role in reproducing experimental data. We check our implementation by benchmarking the ground-state properties of $^3$H, $^3$He and $^4$He against the available Monte Carlo calculations. We then confirm their order-by-order truncation error estimates and further investigate uncertainties in the charge radii obta…
Data and code for "Dipolar coupling of nanoparticle-molecule assemblies: An efficient approach for studying strong coupling"
2021
The data includes the optical excitations of benzene, the optical spectra of coupled benzene-Al NP systems, and fits of the spectra to the coupled oscillator model. The optical spectra in question have been obtained in the dipolar coupling approximation and analyzed in the article "Dipolar coupling of nanoparticle-molecule assemblies: An efficient approach for studying strong coupling" by Jakub Fojt, Tuomas P. Rossi, Tomasz J. Antosiewicz, Mikael Kuisma and Paul Erhart. Scripts for processing of the data, which extract optical spectra from NWChem output files, and fit optical spectra to the coupled oscillator model, are also included. The scripts are written in Python and require …
Heteronormativity meets queering in physical education : the views of PE teachers and LGBTIQ+ students
2021
Background and purpose: In school physical education (PE) lessons, gender is often produced heteronormatively. Lesbian, gay, bi, transgender, intersexual, and queer (LGBTIQ+) students have reported experiences of discrimination and obstacles to participation. This study analyzed Finnish PE teachers and LGBTIQ+ students’ talk about discrimination and problematic practices in PE and how equality in PE might be improved. Theoretical background: We draw on the concepts of heteronormativity and habitus. Habitus provides insight on how gendered norms and inequalities become embodied and contested in different social fields. In the PE context, we define social on the one hand as the heteronormativ…
Search for new decay modes of the $\psi_2(3823)$ and the process $e^+e^-\rightarrow\pi^0\pi^0\psi_2(3823)$
2021
The decays $\psi_2(3823)\rightarrow\gamma\chi_{c0,1,2}, \pi^+\pi^-J/\psi, \pi^0\pi^0J/\psi, \eta J/\psi$, and $\pi^0J/\psi$ are searched for using the reaction $e^+e^-\rightarrow\pi^+\pi^-\psi_2(3823)$ in a 19 fb$^{-1}$ data sample collected at center-of-mass energies between 4.1 and 4.7 GeV with the BESIII detector. The process $\psi_2(3823)\rightarrow\gamma\chi_{c1}$ is observed in a 9 fb$^{-1}$ data sample in the center-of-mass energy range 4.3 to 4.7 GeV, which confirms a previous observation but with a higher significance of $11.8\sigma$, and evidence for $\psi_2(3823)\rightarrow\gamma\chi_{c2}$ is found with a significance of $3.2\sigma$ for the first time. The branching-fraction rati…
Validation of Using Smartphone Built-In Accelerometers to Estimate the Active Energy Expenditures of Full-Time Manual Wheelchair Users with Spinal Co…
2021
[EN] This study aimed to investigate the validity of using built-in smartphone accelerometers to estimate the active energy expenditures of full-time manual wheelchair users with spinal cord injury (SCI). Twenty participants with complete SCI completed 10 5-min daily activities that involved the upper limbs, during which their oxygen consumption and upper limb activity were registered using a portable gas analyzer and a smartphone (placed on the non-dominant arm), respectively. Time series of 1-min averaged oxygen consumption and 55 accelerometer variables (13 variables for each of the four axes and three additional variables for the correlations between axes) were used to estimate three mu…
Caries treatment in a four-year-old boy using hypnosis - a case report.
2021
This clinical case report demonstrates the successful application of hypnosis in an anxious four-year-old boy in whom two primary molars were treated with a composite filling. The almost 16-minute pediatric dental treatment was performed without complications and without interruptions. It could be shown that hypnosis can be used for the pediatric dental treatment of decayed primary tooth lesions. In the specific individual case hypnosis was not only used adjuvant but as an alternative to local anesthesia. A dental anxiety reducing effect and an elimination of pain perception were observed, so that the treatment was possible without anesthesia. It was also found that the communication and ra…
Assessing the Energy-Saving Potential of a Dish-Stirling Concentrator Integrated into Energy Plants in the Tertiary Sector
2021
Energy consumed for air conditioning in residential and tertiary sectors accounts for a large share of global use. To reduce the environmental impacts burdening the covering of such demands, the adoption of renewable energy technologies is increasing. In this regard, this paper evaluates the energy and environmental benefits achievable by integrating a dish-Stirling concentrator into energy systems used for meeting the air conditioning demand of an office building. Two typical reference energy plants are assumed: (i) a natural gas boiler for heating purposes and air-cooled chillers for the cooling periods, and (ii) a reversible heat pump for both heating and cooling. For both systems, a dis…
$\gamma\gamma$ decay as a probe of neutrinoless $\beta\beta$ decay nuclear matrix elements
2021
We study double gamma ($\gamma\gamma$) decay nuclear matrix elements (NMEs) for a wide range of nuclei from titanium to xenon, and explore their relation to neutrinoless double-beta ($0\nu\beta\beta$) NMEs. To favor the comparison, we focus on double-magnetic dipole transitions in the final $\beta\beta$ nuclei, in particular the $\gamma\gamma$ decay of the double isobaric analog of the initial $\beta\beta$ state into the ground state. For the decay with equal-energy photons, our large-scale nuclear shell model results show a good linear correlation between the $\gamma\gamma$ and $0\nu\beta\beta$ NMEs. Our analysis reveals that the correlation holds for $\gamma\gamma$ transitions driven by t…
Toward Pricing Financial Derivatives with an IBM Quantum Computer
2021
Pricing interest-rate financial derivatives is a major problem in finance, in which it is crucial to accurately reproduce the time evolution of interest rates. Several stochastic dynamics have been proposed in the literature to model either the instantaneous interest rate or the instantaneous forward rate. A successful approach to model the latter is the celebrated Heath-Jarrow-Morton framework, in which its dynamics is entirely specified by volatility factors. In its multifactor version, this model considers several noisy components to capture at best the dynamics of several time-maturing forward rates. However, as no general analytical solution is available, there is a trade-off between t…
Pauls Galenieks un rozes
2021
Latviešu botāniķa Paula Galenieka (1891 – 1962) 130. jubilejai veltīta Latvijas Universitātes Muzeja virtuālā izstāde “Pauls Galenieks un rozes”.
Battery characterization via eddy-current imaging with nitrogen-vacancy centers in diamond
2021
Sensitive and accurate diagnostic technologies with magnetic sensors are of great importance for identifying and localizing defects of rechargeable solid batteries in a noninvasive detection. We demonstrate a microwave-free AC magnetometry method with negatively charged NV centers in diamond based on a cross-relaxation feature between NV centers and individual substitutional nitrogen (P1) centers occurring at 51.2 mT. We apply the technique to non-destructive solid-state battery imaging. By detecting the eddy-current-induced magnetic field of the battery, we distinguish a defect on the external electrode and identify structural anomalies within the battery body. The achieved spatial resolut…
Cross-reactivity of a pathogenic autoantibody to a tumor antigen in GABA(A) receptor encephalitis
2021
Encephalitis associated with antibodies against the neuronal gamma-aminobutyric acid A receptor (GABA A -R) is a rare form of autoimmune encephalitis. The pathogenesis is still unknown but autoimmune mechanisms were surmised. Here we identified a strongly expanded B cell clone in the cerebrospinal fluid of a patient with GABA A -R encephalitis. We expressed the antibody produced by it and showed by enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry that it recognizes the GABA A -R. Patch-clamp recordings revealed that it tones down inhibitory synaptic transmission and causes increased excitability of hippocampal CA1 pyramidal neurons. Thus, the antibody likely contributed to…
High-Intensity Interval and Resistance Training Improve Health Outcomes in Older Adults With Coronary Disease.
2021
Both high-intensity interval training (HIIT) and resistance exercises (R) are used in cardiac rehabilitation in patients with coronary artery disease (CAD). However, the combined effect of an HIIT + R exercise program in older adults with CAD is not well investigated. The study's purpose was to assess the changes in anthropometric parameters, physical activity, functional capacity, physiological parameters, and quality of life (QoL) in this population following a combined HIIT + R program.The study was a 2-group (n = 45 each) randomized controlled single-blinded trial.The study was done at a treatment clinic of a tertiary hospital. The mean age of participants was 69.23 ± 4.9 years. The HII…
Location-Awareness for Failure Management in Cellular Networks: An Integrated Approach
2021
Recent years have seen the proliferation of different techniques for outdoor and, especially, indoor positioning. Still being a field in development, localization is expected to be fully pervasive in the next few years. Although the development of such techniques is driven by the commercialization of location-based services (e.g., navigation), its application to support cellular management is considered to be a key approach for improving its resilience and performance. When different approaches have been defined for integrating location information into the failure management activities, they commonly ignore the increase in the dimensionality of the data as well as their integration into th…
Outdoor microalgae-based urban wastewater treatment: recent advances, applications and future perspectives
2021
[EN] Although microalgae-based wastewater treatment has been traditionally carried out in extensive waste stabilization ponds, recent trends focus on the use of microalgae to apply the circular economy principles in the wastewater treatment sector due to the capacity of algae to absorb carbon dioxide while recovering nutrients from sewage. To this aim, the development of new intensive microalgae-based systems with higher efficiency and level of process control is required. Results obtained for these systems at lab scale are generally promising. However, upscaling to outdoor conditions is often uncertain. Some advances have been made in terms of applying open systems at large scale. However,…
La continuidad en las obras de Nietzsche a la luz de su visión de sí mismo
2021
El artículo tiene como objetivo analizar críticamente la convencional división tripartita de la filosofía de Nietzsche que en su forma hiperbólica se expresa en forma de personificación: el Nietzsche joven de la fase wagneriana, el Nietzsche «positivista» o «ilustrado» y el Nietzsche maduro. Se propone contribuir al alegato en favor de la continuidad, prestando especial atención a una variedad de textos en los que Nietzsche contempla la continuidad de su desarrollo intelectual como una unidad coherente. Esta significativa retrospección no indica ruptura o rechazo, sino reconocimiento. Dedicaremos la última sección al peculiar libro que es Ecce Homo, entendido como estrategia de auto-present…
three dimensional structure of human carbonic anhydrase ix in complex with 5-(1-(4-methoxyphenyl)-1h-1,2,3-triazol-4-yl)thiophene-2- sulfonamide
2021
The Moral Foundations of Left-Wing Authoritarianism: On the Character, Cohesion, and Clout of Tribal Equalitarian Discourse
2021
Left-wing authoritarianism remains far less understood than right-wing authoritarianism. We contribute to the literature on the former, which typically relies on surveys, using a new social media analytics approach. We use a list of 60 terms to provide an exploratory sketch of the outlines of a political ideology (tribal equalitarianism) with origins in 19th and 20th century social philosophy. We then use analyses of the English Corpus of Google Books (over 8 million books) and scraped unique tweets from Twitter (n = 202,852) to conduct a series of investigations to discern the extent to which this ideology is cohesive amongst the public, reveals signatures of authoritarianism and has been …
Slow Magnetic Relaxation in a Co 2 Dy Trimer and a Co 2 Dy 2 Tetramer
2021
The combination of Co(III) and Dy(III) with a compartmental Schiff base ligand (H 3 L = 3-[(2-Hydroxy-3-methoxy-benzylidene)-amino]-propane-1,2-diol), presenting three different coordinating pockets, has allowed the synthesis of two novel Co(III)-Dy(III) complexes: [Co 2 Dy(HL) 4 ]NO 3 ·2CH 3 CN ( 1 ), a rare example of trinuclear linear Co III 2 Dy III complex (and the first with slow relaxation of magnetization in absence of a DC field) and [Co 2 Dy 2 (μ 3 -OH) 2 (HL) 2 (OAc) 6 ]·4.6H 2 O ( 2 ), the first tetranuclear Co III 2 Dy III 2 cluster with a rhomb-like structure where the Co(III) ions are connected along the short diagonal of the rhomb. 1 presents two different relaxation process…
The prognostic value of skeletal muscle index on clinical and survival outcomes after cytoreduction and HIPEC for peritoneal metastases from colorect…
2021
BACKGROUND Cytoreductive surgery (CRS) and hypertermic intraperitoneal chemotherapy (HIPEC) represent the most effective strategy to manage peritoneal metastases (PM). This systematic review and meta-analysis aimed to assess the impact of body composition on clinical outcomes in patients with PM. METHODS A systematic literature search was performed using Medline, Web of Science and EMBASE databases from inception to the 20st August 2020. Data were independently extracted by 3 authors. Newcastle-Ottawa Scale was used to assess quality and risk of bias of studies. Pooled analyses were performed using Mantel-Haenszel method to estimate overall effect size with mean differences or odd ratios (O…
Frontispiece: Metal‐Free Electrochemical Synthesis of Sulfonamides Directly from (Hetero)arenes, SO 2 , and Amines
2021
THE ILVA DISASTER: A STUDY OF ENVIRONMENTAL LIABILITY IN ITALY
2021
Purpose The purpose of this paper is to propose a reflection on the importance of individual environmental protection, which recognizes the right of every citizen to take action to obtain compensation for environmental damage, as a damage to his or her existential condition. One of the most discussed environmental issues in Italy today is the lack of personal protection because the European legislator has provided for a public protection of environmental damage. Design/methodology/approach Design/methodology/approach based on the analysis of a well-known environmental disaster, the case of ex Ilva, the author shows how in Italy there is a dangerous lack of protection in environmental matte…
Genetic profile and immunohistochemical study of clear cell renal carcinoma: Pathological-anatomical correlation and prognosis.
2021
Abstract Introduction Renal cell carcinoma (RCC) accounts for 2–3% of all tumors being the most frequent solid lesion in the kidney. Objective To determine what genetic alterations and immunohistochemical (IHC) of clear cell renal carcinoma (ccRCC) are associated with prognosis and tumor aggressiveness. Patients and Methods Experimental analytical study with 57 patients who underwent radical and partial nephrectomy between 2005 and 2011, all with diagnosis of ccRCC and minimum post-operative follow-up of 36 months. The pathological study included IHC determination of biomarkers associated (CAIX, CAM 5.2, CD10, c-erbB-2, EGFR, HIF-1a, Ki67, MDM2, PAX-2 y 8, p53, survivin and VEGFR 1 and 2). …
Observation of $D^0\to K_1(1270)^- e^+\nu_e$
2021
Using 2.93 fb$^{-1}$ of $e^+e^-$ collision data taken with the BESIII detector at a center-of-mass energy of 3.773 $\rm \,GeV$, the observation of the $D^0\to K_1(1270)^- e^+\nu_e$ semileptonic decay is presented. The statistical significance of the decay $D^0\to K_1(1270)^- e^+\nu_e$ is greater than $10\sigma$. The branching fraction of $D^0\to K_1(1270)^- e^+\nu_e$ is measured to be $(1.09\pm0.13^{+0.09}_{-0.16} \pm 0.12)\times10^{-3}$. Here, the first uncertainty is statistical, the second is systematic, and the third originates from the assumed branching fraction of $K_1(1270)^- \rightarrow K^-\pi^+\pi^-$. The fraction of longitudinal polarization in $D^0\to K_1(1270)^- e^+\nu_e$ is det…
false
2021
Introduction: Functional imaging studies have demonstrated the recruitment of additional neural resources as a possible mechanism to compensate for age and Alzheimer’s disease (AD)-related cerebral pathology, the efficacy of which is potentially modulated by underlying structural network connectivity. Additionally, structural network efficiency (SNE) is associated with intelligence across the lifespan, which is a known factor for resilience to cognitive decline. We hypothesized that SNE may be a surrogate of the physiological basis of resilience to cognitive decline in elderly persons without dementia and with age- and AD-related cerebral pathology.Methods: We included 85 cognitively normal…