showing 36 of ~574560 from 574555 documents
Stories of professional development in physiotherapy education
2021
This study examines graduating physiotherapy students' narratives related to their professional development. The data comprised interviews with 33 graduating physiotherapy students. The data were analyzed using the narrative analysis approach. As a result, five different story models were identified. The descriptive story models were named: 1) "Study path dominated by life changes"; 2) "Realizing the connection between physiotherapy theory and practice"; 3) "Self-regulated and practical-oriented learning path"; 4) "Becoming a critical developer"; and 5) "Multiprofessional working towards expertise". In students' stories, there appeared different turning points that illustrated especially me…
Optimality of Increasing Stability for an Inverse Boundary Value Problem
2021
In this work we study the optimality of increasing stability of the inverse boundary value problem (IBVP) for the Schrödinger equation. The rigorous justification of increasing stability for the IBVP for the Schrödinger equation were established by Isakov [Discrete Contin. Dyn. Syst. Ser. S, 4 (2011), pp. 631--640] and by Isakov et al. [Inverse Problems and Applications, Contemp. Math. 615, American Math Society, Providence, RI, 2014, pp. 131--141]. In [Discrete Contin. Dyn. Syst. Ser. S, 4 (2011), pp. 631--640] and [Inverse Problems and Applications, Contemp. Math. 615, American Math Society, Providence, RI, 2014, pp. 131--141], the authors showed that the stability of this IBVP increases …
Letter by Putot et al Regarding Article, “Biomarkers Enhance Discrimination and Prognosis of Type 2 Myocardial Infarction”
2021
Screening for Fabry disease in male patients with arrhythmia requiring a pacemaker or an implantable cardioverter-defibrillator
2021
Big Data in operations and supply chain management: a systematic literature review and future research agenda
2021
In the era of digitalisation, the role of Big Data is proliferating, receiving considerable attention in all sectors and domains. The domain of operations and supply chain management (OSCM) is no different since it offers multiple opportunities to generate a large magnitude of data in real-time. Such extensive opportunities for data generation have attracted academics and practitioners alike who are eager to tap different elements of Big Data application in OSCM. Despite the richness of prior studies, there is limited research that extensively reviews the extant findings to present an overview of the different facets of this area. The current study addresses this gap by conducting a systema…
Three orientations for understanding educational autonomy: school principals’ voices from Australia, Finland, and Jamaica
2021
This paper reports on the findings from a multi-site case study conducted in Australia, Finland and Jamaica which explored the conditions that enabled and constrained the autonomy of school principals. Systematic data collection was carried out in the form of interviews of school principals and the data was analysed using a qualitative approach. The analysis indicates that: (1) school principals’ practices are prefigured by the peculiarities of historical trajectories and ideological traditions enmeshed in schooling sites; (2) these prefiguring arrangements in turn influence varying realisations of autonomous decision making practices across national sites; and (3) even in the expression of…
Leisure-Time Physical Activity Reduces the Risk of Long-Term Sickness Absence Among Older Healthy Female Eldercare Workers
2021
Purpose: This study aimed to examine the association between leisure-time physical activity (PA) and risk of long-term sickness absence (LTSA). Design: Data on LTSA (≥3 consecutive weeks during a 1-year follow-up) were acquired from the Danish Register for Evaluation of Marginalization and linked to a questionnaire via personal identification number. Setting: Eldercare workers from 36 Danish municipalities. Subjects: Data were retrieved from 4605 healthy Danish female eldercare (i.e., workers assisting senior citizens with daily activities and health) aged 19 to 69 years, who answered a questionnaire on health, and work environment in 2005. Measures: Calculated risk of LTSA and its associat…
Value co-creation process and measurement in 4.0 SMEs: An exploratory research in a B2B marketing innovation context
2021
The purpose of this exploratory research is to contribute to the lack of empirical research exploring techniques and protocols that can be used to measure the level of value obtained from using these technologies in the various marketing processes and in a business-to-business (B2B) context. By doing so, firms operating in fast changing dynamic environments can develop the right means to continuously adapt, integrate, reconfigure, and redeploy resources and capabilities to become more competitive and disruptive in their offerings. The phenomenon of interest is described by applying a case study qualitative approach to three 4.0 companies which use virtual reality (VR)/augmented reality (AR)…
Intensity-Based Single Particle Plasmon Sensing.
2021
Plasmon sensors respond to local changes of their surrounding environment with a shift in their resonance wavelength. This response is usually detected by measuring light scattering spectra to determine the resonance wavelength. However, single wavelength detection has become increasingly important because it simplifies the setup, increases speed, and improves statistics. Therefore, we investigated theoretically how the sensitivity toward such single wavelength scattering intensity changes depend on the material and shape of the plasmonic sensor. Surprisingly, simple equations describe this intensity sensitivity very accurately and allow us to distinguish the various contributions: Rayleigh…
“It Is Not the Robot Who Learns, It Is Me.” Treating Severe Dysgraphia Using Child–Robot Interaction
2021
Writing disorders are frequent and impairing. However, social robots may help to improve children's motivation and to propose enjoyable and tailored activities. Here, we have used the Co-writer scenario in which a child is asked to teach a robot how to write via demonstration on a tablet, combined with a series of games we developed to train specifically pressure, tilt, speed, and letter liaison controls. This setup was proposed to a 10-year-old boy with a complex neurodevelopmental disorder combining phonological disorder, attention deficit/hyperactivity disorder, dyslexia, and developmental coordination disorder with severe dysgraphia. Writing impairments were severe and limited his parti…
GESTACOVID project: psychological and perinatal effects in Spanish pregnant women subjected to confinement due to the COVID-19 pandemic
2021
COVID-19 was declared a pandemic and confinement with movement restriction measures were applied in Spain. Postnatal mental disorders are common but frequently undiagnosed, being a risk period to develop anxiety and depression symptoms. The aim of this study is to evaluate the impact of confinement as depressive and anxiety symptoms in pregnant women (PrW) and puerperal women (PuW) mental health, as well as obstetric and perinatal outcomes during this period.The self-administered survey consists of a total of 28 questions, the first 16 providing contextual information and the following ones corresponding to the GHQ-12 that has been evaluated in a binomial form. A logistic regression model h…
Retrospective Analysis of Checkpoint Inhibitor Therapy-Associated Cases of Bullous Pemphigoid From Six German Dermatology Centers
2021
Immune-related adverse events (irAEs) are a class-effect of checkpoint inhibitors (CIs). The development of a Bullous pemphigoid (BP)-like blistering disease, driven by autoantibodies against the hemidesmosomal protein BP180, is a potentially serious irAE whose incidence seems to be increasing. We therefore set out to characterize the clinical and (immuno)histopathological features and treatment responses of cases of BP which developed during or after CI therapy collated in six German tertiary referral centers between 2014 and 2018. We identified twelve cases of BP which emerged during and/or after CI therapy. The time interval between the initiation of CI therapy and the diagnosis of BP wa…
Hypusinated eIF5A is required for the translation of collagen
2021
AbstractThe evolutionary conserved elongation factor eIF5A is required for the translation of mRNAs that encode protein sequences with consecutive prolines or combined with glycine and charged amino acids. Mammalian collagens are enriched in putative eIF5A-dependent Pro-Gly-containing tripeptides. Here, we show that eIF5A is needed for heterologous expression of collagen in yeast, and using a dual luciferase reporter system we confirmed that eIF5A depletion interrupts translation at Pro-Gly-collagenic motifs. Using mouse fibroblasts, we showed that depletion of active eIF5A reduced collagen 1α (Col1a1) content, which became concentrated around the nuclei, in contrast to a stronger and all o…
Understanding charge transport in wavy 2D covalent organic frameworks
2021
Understanding charge transport in 2D covalent organic frameworks is crucial to increase their performance. Herein a new wavy 2D covalent organic framework has been designed, synthesized and studied to shine light on the structural factors that dominate charge transport.
Single Out-of-Resonance Dielectric Nanoparticles as Molecular Sensors.
2021
Light scattering from single nanoparticles and nanostructures is a commonly used readout method for nanosensors. Increasing the spectral sensitivity of resonant nanosensors to changes in their local surrounding has been the focus of many studies. Switching from spectral to intensity monitoring allows one to investigate nonresonant or out-of-resonance dielectric nanoparticles. Here, we systematically compared such dielectric silica nanoparticles with plasmonic gold nanorods by deriving analytical expressions and by performing experiments. The experiments show a similar sensitivity for the detection of an adsorbate layer for both particle types, which is in good agreement with theory. The fla…
Patient‐specific titanium meshes: Future trend or current technology?
2021
Fiberized diamond-based vector magnetometers
2021
Frontiers 2, 732748 (2021). doi:10.3389/fphot.2021.732748
Optical and ultraviolet pulsed emission from an accreting millisecond pulsar
2021
Ambrosino, F., et al.
Monotone cubic spline interpolation for functions with a strong gradient
2021
Abstract Spline interpolation has been used in several applications due to its favorable properties regarding smoothness and accuracy of the interpolant. However, when there exists a discontinuity or a steep gradient in the data, some artifacts can appear due to the Gibbs phenomenon. Also, preservation of data monotonicity is a requirement in some applications, and that property is not automatically verified by the interpolator. Hence, some additional techniques have to be incorporated so as to ensure monotonicity. The final interpolator is not actually a spline as C 2 regularity and monotonicity are not ensured at the same time. In this paper, we study sufficient conditions to obtain monot…
Linguistica Educativa e bisogni speciali Origini e stato dell’arte della ricerca italiana
2021
This chapter provides an overview of the studies on Special Educational Needs (SEN) conducted in Italy in the field of Educational Linguistics (EL). The first part analyses the papers produced between 2008 and 2019. The results show that EL research on SEN has grown quantitatively and diversified the types of SEN being studied, ranging from sensory and intellectual disability to socio-cultural disadvantages. The second part discusses early studies within the field of EL, dating back to 1970s, including some pioneering experimental reports whose results are in line with recent trends in cognitive linguistic research. Overall, data show that EL research on SEN is neither a recent phenomenon n…
Sensitivity of the Cherenkov Telescope Array for probing cosmology and fundamental physics with gamma-ray propagation
2021
Full list of authors: Abdalla, H.; Abe, H.; Acero, F.; Acharyya, A.; Adam, R.; Agudo, I; Aguirre-Santaella, A.; Alfaro, R.; Alfaro, J.; Alispach, C.; Aloisio, R.; Batista, R. Alves; Amati, L.; Amato, E.; Ambrosi, G.; Anguner, E. O.; Araudo, A.; Armstrong, T.; Arqueros, F.; Arrabito, L.; Asano, K.; Ascasibar, Y.; Ashley, M.; Backes, M.; Balazs, C.; Balbo, M.; Balmaverde, B.; Baquero Larriva, A.; Martins, V. Barbosa; Barkov, M.; Baroncelli, L.; de Almeida, U. Barres; Barrio, J. A.; Batista, P-, I; Becerra Gonzalez, J.; Becherini, Y.; Beck, G.; Tjus, J. Becker; Belmont, R.; Benbow, W.; Bernardini, E.; Berti, A.; Berton, M.; Bertucci, B.; Beshley, V; Bi, B.; Biasuzzi, B.; Biland, A.; Bissaldi, …
Aestivation motifs explain hypertension and muscle mass loss in mice with psoriatic skin barrier defect
2021
Aim Recent evidence suggests that arterial hypertension could be alternatively explained as a physiological adaptation response to water shortage, termed aestivation, which relies on complex multi-organ metabolic adjustments to prevent dehydration. Here, we tested the hypothesis that chronic water loss across diseased skin leads to similar adaptive water conservation responses as observed in experimental renal failure or high salt diet. Methods We studied mice with keratinocyte-specific overexpression of IL-17A which develop severe psoriasis-like skin disease. We measured transepidermal water loss and solute and water excretion in the urine. We quantified glomerular filtration rate (GFR) by…
A novel multidimensional questionnaire for the assessment of emotional dysregulation in adolescents: Reactivity, Intensity, Polarity and Stability qu…
2021
Abstract Background The failure to regulate emotions, namely emotional dysregulation (ED), is a relevant construct in adolescent psychiatry, in terms of prognostic and developmental implications. We developed and validated a novel self-report questionnaire for the assessment of ED, the RIPoSt-Y, both in clinical and non-clinical samples. Methods Items selection and subscales construction were conducted on healthy controls (n=374), while test-retest reliability was evaluated in a subsample (n=72); internal consistency was examined both in the control group and in two clinical samples, respectively including patients with Bipolar Spectrum Disorders (BSD; n=44) and ADHD (n=34). Construct, conc…
Cloning and training collective intelligence with generative adversarial networks
2021
Industry 4.0 and highly automated critical infrastructure can be seen as cyber‐physical‐social systems controlled by the Collective Intelligence. Such systems are essential for the functioning of the society and economy. On one hand, they have flexible infrastructure of heterogeneous systems and assets. On the other hand, they are social systems, which include collaborating humans and artificial decision makers. Such (human plus machine) resources must be pre‐trained to perform their mission with high efficiency. Both human and machine learning approaches must be bridged to enable such training. The importance of these systems requires the anticipation of the potential and previously unknow…
false
2021
Over the past few decades, extensively drug resistant (XDR) resistant Klebsiella pneumoniae has become a notable burden to healthcare all over the world. Especially carbapenemase-producing strains are problematic due to their capability to withstand even last resort antibiotics. Some sequence types (STs) of K. pneumoniae are significantly more prevalent in hospital settings in comparison to other equally resistant strains. This provokes the question whether or not there are phenotypic characteristics that may render certain K. pneumoniae more suitable for epidemic dispersal between patients, hospitals, and different environments. In this study, we selected seven epidemic and non-epidemic ca…
Slow Relaxation of the Magnetization in Anilato-Based Dy(III) 2D Lattices.
2021
The search for two- and three-dimensional materials with slow relaxation of the magnetization (single-ion magnets, SIM and single-molecule magnets, SMM) has become a very active area in recent years. Here we show how it is possible to prepare two-dimensional SIMs by combining Dy(III) with two different anilato-type ligands (dianions of the 3,6-disubstituted-2,5-dihydroxy-1,4-benzoquinone: C6O4X22−, with X = H and Cl) in dimethyl sulfoxide (dmso). The two compounds prepared, formulated as: [Dy2(C6O4H2)3(dmso)2(H2O)2]·2dmso·18H2O (1) and [Dy2(C6O4Cl2)3(dmso)4]·2dmso·2H2O (2) show distorted hexagonal honeycomb layers with the solvent molecules (dmso and H2O) located in the interlayer space and…
Hierarchical cross-scale analysis identifies parallel ventral striatal networks coding for dynamic and stabilized olfactory reward predictions
2021
SUMMARYThe unbiased identification of brain circuits responsible for behavior and their local cellular computations is a challenge for neuroscience. We establish here a hierarchical cross-scale approach from behavioral modeling and fMRI in task-performing mice to cellular network dynamics to identify how reward predictions are represented in the forebrain upon olfactory conditioning. fMRI identified functional segregation in reward prediction and error computations among olfactory cortices and subcortical circuits. Among them, the olfactory tubercle contributed both to dynamic reward predictions and prediction error. In this region, cellular recordings revealed two parallel neuronal populat…
6exo
2021
Hetero-oligomerization of Bacillus thuringiensis Cry1A proteins enhance binding to the ABCC2 transporter of Spodoptera exigua
2021
The ATP binding cassette (ABC) transporters are membrane proteins that can act as putative receptors for Cry proteins from Bacillus thuringiensis (Bt) in the midgut of different insects. For the beet armyworm, Spodoptera exigua, ABCC2 and ABCC3 have been found to interact with Cry1A proteins, the main insecticidal proteins used in Bt crops, as well as Bt-based pesticides. The ABCC2 has shown to have specific binding towards Cry1Ac and is involved in the toxic process of Cry1A proteins, but the role of this transporter and how it relates with the Cry1A proteins is still unknown. Here, we have characterized the interactions between the SeABCC2 and the main proteins that bind to the receptor. …
Do different models induce changes in mortality indicators? That is a key question for extending the Lee-Carter model
2021
[EN] The parametric model introduced by Lee and Carter in 1992 for modeling mortality rates in the USA was a seminal development in forecasting life expectancies and has been widely used since then. Different extensions of this model, using different hypotheses about the data, constraints on the parameters, and appropriate methods have led to improvements in the model's fit to historical data and the model's forecasting of the future. This paper's main objective is to evaluate if differences between models are reflected in different mortality indicators' forecasts. To this end, nine sets of indicator predictions were generated by crossing three models and three block-bootstrap samples with …
Evaluation of the Physicochemical Properties of the Iron Nanoparticle Drug Products: Brand and Generic Sodium Ferric Gluconate
2021
Complex iron nanoparticle-based drugs are one of the oldest and most frequently administered classes of nanomedicines. In the US, there are seven FDA-approved iron nanoparticle reference drug products, of which one also has an approved generic drug product (i.e., sodium ferric gluconate (SFG)). These products are indicated for the treatment of iron deficiency anemia and are administered intravenously. On the molecular level, iron nanomedicines are colloids composed of an iron oxide core with a carbohydrate coating. This formulation makes nanomedicines more complex than conventional small molecule drugs. As such, these products are often referred to as nonbiological complex drugs (e.g., by t…
Are locally finite MV-algebras a variety?
2021
We answer Mundici's problem number 3 (D. Mundici. Advanced {\L}ukasiewicz calculus. Trends in Logic Vol. 35. Springer 2011, p. 235): Is the category of locally finite MV-algebras equivalent to an equational class? We prove: (i) The category of locally finite MV-algebras is not equivalent to any finitary variety. (ii) More is true: the category of locally finite MV-algebras is not equivalent to any finitely-sorted finitary quasi-variety. (iii) The category of locally finite MV-algebras is equivalent to an infinitary variety; with operations of at most countable arity. (iv) The category of locally finite MV-algebras is equivalent to a countably-sorted finitary variety. Our proofs rest upon th…
Analgesic hypnotic treatment in a post-stroke patient
2021
In recent years, hypnotic suggestions have been used in several clinical conditions. This treatment is often used for anxiety treatment, somatization, and post-traumatic stress disorder. Hypnotic analgesia is one of the most clinically useful phenomena of hypnosis. The article describes the case of a patient who underwent hypnotic treatments for hypersensitivity and chronic pain. Results showed an improvement of pain control and a decrease of pain hypersensibility. In addition, during rehabilitative treatments, the patient reported a high level of compliance with the multidisciplinary team. These findings suggest that hypnosis could be a useful treatment for post-stroke pain management.
Dataset related to article "The unfolded protein response in amyotrophic later sclerosis: results of a phase 2 trial"
2021
The data support the findings of the study "The Unfolded Protein Response in Amyotrophic Later Sclerosis: Results of a Phase 2 Trial". They include demographic and clinical data at baseline, and changes measured by the primary and secondary outcomes at 6 months
Paula Galenieka disertācija “Latvijas rozes”
2021
Atzīmējot botāniķa Paula Galenieka (1891-1962) 130 gadu jubileju par LU Muzeja 2021. gada februāra mēneša priekšmetu tika izvēlēts muzeja jaunieguvums profesora disertācija “Latvijas rozes”, kas tika aizstāvēta 1936. gadā. Rakstā sniegts ieskats par disertāciju un tās tapšanu.
Genetic profile and immunohistochemical study of clear cell renal carcinoma: Pathological-anatomical correlation and prognosis.
2021
Abstract Introduction Renal cell carcinoma (RCC) accounts for 2–3% of all tumors being the most frequent solid lesion in the kidney. Objective To determine what genetic alterations and immunohistochemical (IHC) of clear cell renal carcinoma (ccRCC) are associated with prognosis and tumor aggressiveness. Patients and Methods Experimental analytical study with 57 patients who underwent radical and partial nephrectomy between 2005 and 2011, all with diagnosis of ccRCC and minimum post-operative follow-up of 36 months. The pathological study included IHC determination of biomarkers associated (CAIX, CAM 5.2, CD10, c-erbB-2, EGFR, HIF-1a, Ki67, MDM2, PAX-2 y 8, p53, survivin and VEGFR 1 and 2). …